KR102501827B1 - 바이러스-특이적인 t-세포의 활성화 및 확장을 위한 플랫폼 - Google Patents
바이러스-특이적인 t-세포의 활성화 및 확장을 위한 플랫폼 Download PDFInfo
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- KR102501827B1 KR102501827B1 KR1020197010798A KR20197010798A KR102501827B1 KR 102501827 B1 KR102501827 B1 KR 102501827B1 KR 1020197010798 A KR1020197010798 A KR 1020197010798A KR 20197010798 A KR20197010798 A KR 20197010798A KR 102501827 B1 KR102501827 B1 KR 102501827B1
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
- C12N5/0636—T lymphocytes
- C12N5/0638—Cytotoxic T lymphocytes [CTL] or lymphokine activated killer cells [LAK]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/14—Blood; Artificial blood
- A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
- A61K40/10—Cellular immunotherapy characterised by the cell type used
- A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
- A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
- A61K40/41—Vertebrate antigens
- A61K40/42—Cancer antigens
- A61K40/4202—Receptors, cell surface antigens or cell surface determinants
- A61K40/421—Immunoglobulin superfamily
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K40/00—Cellular immunotherapy
- A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
- A61K40/46—Viral antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2121/00—Preparations for use in therapy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
- A61K2239/46—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterised by the cancer treated
- A61K2239/48—Blood cells, e.g. leukemia or lymphoma
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/23—Interleukins [IL]
- C12N2501/2307—Interleukin-7 (IL-7)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2501/00—Active agents used in cell culture processes, e.g. differentation
- C12N2501/20—Cytokines; Chemokines
- C12N2501/23—Interleukins [IL]
- C12N2501/2315—Interleukin-15 (IL-15)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/16011—Herpesviridae
- C12N2710/16211—Lymphocryptovirus, e.g. human herpesvirus 4, Epstein-Barr Virus
- C12N2710/16234—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/16011—Human Immunodeficiency Virus, HIV
- C12N2740/16034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16111—Influenzavirus A, i.e. influenza A virus
- C12N2760/16134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Immunology (AREA)
- Virology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Cell Biology (AREA)
- Hematology (AREA)
- Mycology (AREA)
- General Engineering & Computer Science (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Tropical Medicine & Parasitology (AREA)
- AIDS & HIV (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Developmental Biology & Embryology (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662395438P | 2016-09-16 | 2016-09-16 | |
| US62/395,438 | 2016-09-16 | ||
| PCT/US2017/051284 WO2018052947A1 (en) | 2016-09-16 | 2017-09-13 | Platform for activation and expansion of virus-specific t-cells |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| KR20190051039A KR20190051039A (ko) | 2019-05-14 |
| KR102501827B1 true KR102501827B1 (ko) | 2023-02-22 |
Family
ID=61619728
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020197010798A Active KR102501827B1 (ko) | 2016-09-16 | 2017-09-13 | 바이러스-특이적인 t-세포의 활성화 및 확장을 위한 플랫폼 |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US20190194619A1 (enExample) |
| EP (1) | EP3512531A4 (enExample) |
| JP (1) | JP7002769B2 (enExample) |
| KR (1) | KR102501827B1 (enExample) |
| CN (1) | CN110177558B (enExample) |
| AU (1) | AU2017326173B2 (enExample) |
| CA (1) | CA3036966A1 (enExample) |
| NZ (1) | NZ751571A (enExample) |
| TW (1) | TWI780069B (enExample) |
| WO (1) | WO2018052947A1 (enExample) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SG178885A1 (en) | 2009-08-24 | 2012-04-27 | Baylor College Medicine | Generation of ctl lines with specificity against multiple tumor antigens or multiple viruses |
| GB201121308D0 (en) | 2011-12-12 | 2012-01-25 | Cell Medica Ltd | Process |
| ES2748652T3 (es) | 2012-02-09 | 2020-03-17 | Baylor College Medicine | Mezclas pep para generar CTL multivíricos con amplia especificidad |
| HK1258649A1 (zh) | 2015-09-18 | 2019-11-15 | Baylor College Of Medicine | 来自病原体的免疫原性抗原鉴定以及与临床效力的相关性 |
| US9642906B2 (en) * | 2016-09-16 | 2017-05-09 | Baylor College Of Medicine | Generation of HPV-specific T-cells |
| PT3558339T (pt) | 2016-12-22 | 2024-03-15 | Cue Biopharma Inc | Polipeptídeos multiméricos moduladores de células t e métodos de utilização dos mesmos |
| WO2019202118A1 (en) * | 2018-04-20 | 2019-10-24 | Baylor College Of Medicine | Oncolytic virotherapy and immunotherapy |
| CN108841792A (zh) * | 2018-06-14 | 2018-11-20 | 浙江大学 | 靶向cd19和ebna1基因修饰的t细胞及其制备方法与应用 |
| US20210301255A1 (en) * | 2018-09-10 | 2021-09-30 | Atara Biotherapeutics, Inc. | Methods for expanding antigen-specific car-t cells, compositions and uses related thereto |
| US10772914B1 (en) * | 2019-04-18 | 2020-09-15 | Baylor College Of Medicine | EBV-specific immune cells |
| WO2022056285A1 (en) * | 2020-09-10 | 2022-03-17 | Children's National Medical Center | Cytokine cocktails for selective expansion of t cell subsets |
| JP2023500573A (ja) * | 2019-10-23 | 2023-01-10 | キュー バイオファーマ, インコーポレイテッド | 改変された細胞傷害性t細胞及びその使用方法 |
| EP4061386A4 (en) * | 2019-11-19 | 2024-01-10 | Acibadem Labmed Saglik Hizmetleri Anonim Sirketi | METHOD FOR PRODUCING MULTIVIRUS-SPECIFIC T CELLS |
| BR112022009679A2 (pt) | 2019-11-26 | 2022-08-09 | Novartis Ag | Receptores de antígeno quimérico cd19 e cd22 e usos dos mesmos |
| WO2021221927A1 (en) | 2020-04-27 | 2021-11-04 | Parsons Corporation | Narrowband iq signal obfuscation |
| WO2021231376A2 (en) | 2020-05-12 | 2021-11-18 | Cue Biopharma, Inc. | Multimeric t-cell modulatory polypeptides and methods of use thereof |
| JP2023548382A (ja) * | 2020-10-28 | 2023-11-16 | ティエスディ・ライフ・サイエンシーズ・カンパニー・リミテッド | 異種免疫細胞に対する化学走性を誘導する形質転換された免疫細胞 |
| CA3218235A1 (en) * | 2021-04-27 | 2022-11-03 | Baylor College Of Medicine | Virus-specific immune cells expressing chimeric antigen receptors |
| TW202307210A (zh) | 2021-06-01 | 2023-02-16 | 瑞士商諾華公司 | Cd19和cd22嵌合抗原受體及其用途 |
| WO2023198744A1 (en) | 2022-04-13 | 2023-10-19 | Tessa Therapeutics Ltd. | Therapeutic t cell product |
| EP4509137A1 (en) * | 2023-06-14 | 2025-02-19 | Kuiper, Inc. | A chimeric antigen receptor combinatorial multi-antigen targeted allogeneic t cell immunotherapy with reduced risk of t cell exhaustion, host versus graft rejection, and graft versus host disease |
| GB202318977D0 (en) * | 2023-12-12 | 2024-01-24 | Swarm Oncology Ltd | Method |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20020155594A1 (en) | 2001-03-27 | 2002-10-24 | Hsieh Helen V. | Method and apparatus for culturing cells |
| US20150017723A1 (en) | 2011-12-12 | 2015-01-15 | Cell Medica Limited | Process of expanding t cells |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT1956080E (pt) * | 2005-08-08 | 2011-12-30 | San Raffaele Centro Fond | Uso de il-7 e il-15 para a modificação genética de linfócitos t da memória |
| DK2856876T3 (en) * | 2007-03-30 | 2018-04-03 | Memorial Sloan Kettering Cancer Center | Constitutive expression of co-stimulatory ligands on adoptively transmitted T lymphocytes |
| EP2065462A1 (en) * | 2007-11-27 | 2009-06-03 | Helmholtz Zentrum München Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH) | Ex vivo method for producing a preparation containing CD4+ T cells specific for EBV structural antigens |
| WO2010119307A1 (en) * | 2009-04-14 | 2010-10-21 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Method for stimulating antigen-specific t cell responses using accelerated co-cultured dendritic cells |
| SG178885A1 (en) * | 2009-08-24 | 2012-04-27 | Baylor College Medicine | Generation of ctl lines with specificity against multiple tumor antigens or multiple viruses |
| PH12012502233A1 (en) * | 2010-04-13 | 2022-10-05 | Immunovative Therapies Ltd | Methods and compositions for inhibition of treg cells |
| ES2748652T3 (es) * | 2012-02-09 | 2020-03-17 | Baylor College Medicine | Mezclas pep para generar CTL multivíricos con amplia especificidad |
| KR101545217B1 (ko) * | 2012-10-29 | 2015-08-18 | 연세대학교 산학협력단 | 줄기세포의 미분화 배양 및 분화 증진을 위한 폴리도파민-펩타이드 고정화 표면 기질 및 그 제조 방법 |
| CN105335280A (zh) * | 2014-07-16 | 2016-02-17 | 北京奇虎科技有限公司 | 程序性能测试方法和装置 |
| IL292650B2 (en) * | 2014-09-19 | 2024-04-01 | Hope City | COSTIMULATORY CHIMERIC ANTIGEN RECEPTOR T CELLS TARGETING IL13Ra2 |
| US20180079824A1 (en) * | 2015-03-18 | 2018-03-22 | Baylor College Of Medicine | HER2/ErbB2 Chimeric Antigen Receptor |
| US12478670B2 (en) * | 2015-03-20 | 2025-11-25 | Children's National Medical Center | Generating HPV antigen-specific T cells from a naïve T cell population |
| CN107835690A (zh) * | 2015-05-12 | 2018-03-23 | 纪念斯隆-凯特林癌症中心 | 通过t细胞疗法治疗埃巴病毒相关淋巴细胞增生性病症的方法 |
| CN114958738A (zh) * | 2015-06-09 | 2022-08-30 | 淋巴-淋巴细胞活化技术公司 | 用于生产TCRγδ+T细胞的方法 |
| AU2017289879B2 (en) * | 2016-06-27 | 2023-04-20 | Yeda Research And Development Co. Ltd. | Veto cells generated from memory T cells |
-
2017
- 2017-09-13 WO PCT/US2017/051284 patent/WO2018052947A1/en not_active Ceased
- 2017-09-13 CA CA3036966A patent/CA3036966A1/en active Pending
- 2017-09-13 EP EP17851424.6A patent/EP3512531A4/en active Pending
- 2017-09-13 CN CN201780066129.4A patent/CN110177558B/zh active Active
- 2017-09-13 KR KR1020197010798A patent/KR102501827B1/ko active Active
- 2017-09-13 JP JP2019515306A patent/JP7002769B2/ja active Active
- 2017-09-13 NZ NZ751571A patent/NZ751571A/en unknown
- 2017-09-13 US US16/331,494 patent/US20190194619A1/en not_active Abandoned
- 2017-09-13 AU AU2017326173A patent/AU2017326173B2/en active Active
- 2017-09-15 TW TW106131831A patent/TWI780069B/zh active
-
2022
- 2022-04-28 US US17/661,060 patent/US20220251509A1/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20020155594A1 (en) | 2001-03-27 | 2002-10-24 | Hsieh Helen V. | Method and apparatus for culturing cells |
| US20150017723A1 (en) | 2011-12-12 | 2015-01-15 | Cell Medica Limited | Process of expanding t cells |
Non-Patent Citations (2)
| Title |
|---|
| Lam, S. et al., JPT PepMixTM ULTRA Peptide Pool Application Note (2015)* |
| Teschner, D. et al., Bone Marrow Transplantation (2013) 49(1):138-144* |
Also Published As
| Publication number | Publication date |
|---|---|
| EP3512531A4 (en) | 2020-03-11 |
| CN110177558B (zh) | 2025-02-28 |
| NZ751571A (en) | 2025-10-31 |
| EP3512531A1 (en) | 2019-07-24 |
| JP2019531722A (ja) | 2019-11-07 |
| US20190194619A1 (en) | 2019-06-27 |
| CA3036966A1 (en) | 2018-03-22 |
| US20220251509A1 (en) | 2022-08-11 |
| TWI780069B (zh) | 2022-10-11 |
| KR20190051039A (ko) | 2019-05-14 |
| JP7002769B2 (ja) | 2022-02-04 |
| WO2018052947A1 (en) | 2018-03-22 |
| AU2017326173B2 (en) | 2022-08-18 |
| CN110177558A (zh) | 2019-08-27 |
| AU2017326173A1 (en) | 2019-04-11 |
| TW201814041A (zh) | 2018-04-16 |
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