KR102499737B1 - 종양 항원을 발현하는 재조합 폭스바이러스 및 면역 체크포인트 분자 길항제 또는 효현제로 암을 치료하기 위한 복합 요법 - Google Patents

종양 항원을 발현하는 재조합 폭스바이러스 및 면역 체크포인트 분자 길항제 또는 효현제로 암을 치료하기 위한 복합 요법 Download PDF

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KR102499737B1
KR102499737B1 KR1020167030977A KR20167030977A KR102499737B1 KR 102499737 B1 KR102499737 B1 KR 102499737B1 KR 1020167030977 A KR1020167030977 A KR 1020167030977A KR 20167030977 A KR20167030977 A KR 20167030977A KR 102499737 B1 KR102499737 B1 KR 102499737B1
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immune checkpoint
antagonist
mva
cancer
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KR20170003556A (ko
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수잔 포이
스테파니 만들
라이언 라운트리
알렉스 프란즈소프
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버베리안 노딕 에이/에스
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    • A—HUMAN NECESSITIES
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KR1020167030977A 2014-05-13 2015-05-08 종양 항원을 발현하는 재조합 폭스바이러스 및 면역 체크포인트 분자 길항제 또는 효현제로 암을 치료하기 위한 복합 요법 Active KR102499737B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201461992788P 2014-05-13 2014-05-13
US61/992,788 2014-05-13
PCT/US2015/029855 WO2015175334A2 (en) 2014-05-13 2015-05-08 Combination therapy for treating cancer with a recombinant poxvirus expressing a tumor antigen and an immune checkpoint molecule antagonist or agonist

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KR20170003556A KR20170003556A (ko) 2017-01-09
KR102499737B1 true KR102499737B1 (ko) 2023-02-13

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US (1) US20170266270A1 (enExample)
EP (1) EP3142690B1 (enExample)
JP (1) JP6747981B2 (enExample)
KR (1) KR102499737B1 (enExample)
CN (1) CN106456747A (enExample)
AU (1) AU2015259510B2 (enExample)
CA (1) CA2946418C (enExample)
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IL (1) IL248507B (enExample)
NZ (1) NZ725459A (enExample)
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CA2991976A1 (en) 2015-07-13 2017-01-19 Cytomx Therapeutics, Inc. Anti-pd-1 antibodies, activatable anti-pd-1 antibodies, and methods of use thereof
US10512662B2 (en) 2016-02-25 2019-12-24 Memorial Sloan Kettering Cancer Center Replication competent attenuated vaccinia viruses with deletion of thymidine kinase with and without the expression of human Flt3L or GM-CSF for cancer immunotherapy
US10736962B2 (en) 2016-02-25 2020-08-11 Memorial Sloan Kettering Cancer Center Recombinant MVA or MVADELE3L expressing human FLT3L and use thereof as immuno-therapeutic agents against solid tumors
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EP3225253A1 (en) * 2016-04-01 2017-10-04 Deutsches Krebsforschungszentrum Stiftung des Öffentlichen Rechts Cancer therapy with an oncolytic virus combined with a checkpoint inhibitor
CN107281474A (zh) * 2016-04-11 2017-10-24 中国科学院上海巴斯德研究所 增强抗肿瘤免疫反应的新型免疫策略和免疫组合物
HUE065176T2 (hu) 2016-06-02 2024-05-28 Ultimovacs Asa Vakcina kombinációban immunellenõrzõpont inhibitorral felhasználásra rák kezelésében
RS62589B1 (sr) * 2016-11-02 2021-12-31 Jounce Therapeutics Inc Antitela na pd-1 i njihova upotreba
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JP7334124B2 (ja) 2017-06-21 2023-08-28 トランジェーヌ 個別化ワクチン
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US20210177964A1 (en) * 2017-11-06 2021-06-17 Memorial Sloan Kettering Cancer Center Heat-inactivated vaccinia virus as a vaccine immune adjuvant
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TWI816603B (zh) * 2018-04-23 2023-09-21 美商南特細胞公司 新抗原表位疫苗及免疫刺激組合物及方法
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CN113056284A (zh) * 2018-11-20 2021-06-29 巴法里安诺迪克有限公司 通过肿瘤内和/或静脉内施用编码4-1bbl(cd137l)和/或cd40l的重组mva治疗癌症的疗法
TWI852977B (zh) 2019-01-10 2024-08-21 美商健生生物科技公司 前列腺新抗原及其用途
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IL248507A0 (en) 2016-12-29
WO2015175334A2 (en) 2015-11-19
AU2015259510A1 (en) 2016-11-10
US20170266270A1 (en) 2017-09-21
RU2724433C2 (ru) 2020-06-23
CA2946418C (en) 2023-07-04
EP3142690A2 (en) 2017-03-22
DK3142690T3 (da) 2022-05-09
NZ725459A (en) 2023-04-28
RU2016148311A3 (enExample) 2018-12-26
AU2015259510B2 (en) 2020-10-01
JP6747981B2 (ja) 2020-08-26
EP3142690B1 (en) 2022-02-23
CA2946418A1 (en) 2015-11-19
JP2017515837A (ja) 2017-06-15
IL248507B (en) 2022-07-01
ES2913236T3 (es) 2022-06-01
CN106456747A (zh) 2017-02-22
WO2015175334A3 (en) 2016-02-04
KR20170003556A (ko) 2017-01-09
RU2016148311A (ru) 2018-06-18

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