KR102491748B1 - 정형외과적 질병의 치료를 위한 조성물 및 방법 - Google Patents

정형외과적 질병의 치료를 위한 조성물 및 방법 Download PDF

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KR102491748B1
KR102491748B1 KR1020197012314A KR20197012314A KR102491748B1 KR 102491748 B1 KR102491748 B1 KR 102491748B1 KR 1020197012314 A KR1020197012314 A KR 1020197012314A KR 20197012314 A KR20197012314 A KR 20197012314A KR 102491748 B1 KR102491748 B1 KR 102491748B1
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South Korea
Prior art keywords
ginger
composition
citrulline
arginine
bone
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Korean (ko)
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KR20190061045A (ko
Inventor
제이콥 라퍼
레베카 라퍼
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케이.엘.알.엠., 엘엘씨
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/906—Zingiberaceae (Ginger family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/906—Zingiberaceae (Ginger family)
    • A61K36/9068—Zingiber, e.g. garden ginger
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/77—Sapindaceae (Soapberry family), e.g. lychee or soapberry
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis

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  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Botany (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Medical Informatics (AREA)
  • Biotechnology (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Rheumatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Coloring Foods And Improving Nutritive Qualities (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
KR1020197012314A 2016-09-29 2017-09-29 정형외과적 질병의 치료를 위한 조성물 및 방법 Active KR102491748B1 (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201662401629P 2016-09-29 2016-09-29
US62/401,629 2016-09-29
US201762511601P 2017-05-26 2017-05-26
US62/511,601 2017-05-26
PCT/US2017/054284 WO2018064469A1 (en) 2016-09-29 2017-09-29 Compositions and methods for the treatment of orthopedic ailments

Publications (2)

Publication Number Publication Date
KR20190061045A KR20190061045A (ko) 2019-06-04
KR102491748B1 true KR102491748B1 (ko) 2023-01-25

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KR1020197012314A Active KR102491748B1 (ko) 2016-09-29 2017-09-29 정형외과적 질병의 치료를 위한 조성물 및 방법

Country Status (9)

Country Link
US (3) US10426812B2 (OSRAM)
EP (1) EP3518951B1 (OSRAM)
JP (1) JP7075136B2 (OSRAM)
KR (1) KR102491748B1 (OSRAM)
CN (1) CN110087664B (OSRAM)
AU (1) AU2017336916A1 (OSRAM)
ES (1) ES2971281T3 (OSRAM)
IL (1) IL265571B (OSRAM)
WO (1) WO2018064469A1 (OSRAM)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3518951B1 (en) * 2016-09-29 2024-01-10 K.L.R.M., Llc Compositions for use in the treatment of osteoporis and bone fractures
US20200246414A1 (en) * 2019-02-06 2020-08-06 K.L.R.M., Llc Compositions and methods for the treatment of constipation and other ailments of the gastrointestinal system
CN112791171A (zh) * 2019-11-13 2021-05-14 内蒙古伊利实业集团股份有限公司 姜或其提取物用于防治骨质疏松的用途
CN119818501A (zh) * 2025-01-14 2025-04-15 北京大学口腔医学院 西地那非的新用途

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2000191542A (ja) * 1998-12-25 2000-07-11 Lion Corp 骨粗鬆症予防、治療剤
US20120121740A1 (en) * 2010-10-19 2012-05-17 K.L.R.M., Llc Compositions and methods for treating, inhibiting the onset, and slowing the progression of erectile dysfunction including naturally occurring age related erectile dysfunction

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6210701B1 (en) 1999-04-30 2001-04-03 Healthcomm International, Inc. Medical food for treating inflammation-related diseases
US7163958B2 (en) 2002-07-03 2007-01-16 Nitromed Inc. Nitrosated nonsteroidal antiinflammatory compounds, compositions and methods of use
US20040097467A1 (en) * 2002-08-22 2004-05-20 Vijaya Juturu Arginine silicate inositol complex and use thereof
US20070243132A1 (en) * 2005-12-22 2007-10-18 Apollo Life Sciences Limited Transdermal delivery of pharmaceutical agents
US20120093950A1 (en) * 2010-10-19 2012-04-19 Klrm, Llc Compositions and methods for treating, inhibiting the onset, and slowing the progression of erectile dysfunction including naturally occuring age related erectile dysfunction
WO2016141331A1 (en) * 2015-03-04 2016-09-09 K.L.R.M., Llc Methods and compositions for extending the efficacy of phosphodiesterase inhibitors for treating erectile dysfunction
EP3518951B1 (en) * 2016-09-29 2024-01-10 K.L.R.M., Llc Compositions for use in the treatment of osteoporis and bone fractures

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2000191542A (ja) * 1998-12-25 2000-07-11 Lion Corp 骨粗鬆症予防、治療剤
US20120121740A1 (en) * 2010-10-19 2012-05-17 K.L.R.M., Llc Compositions and methods for treating, inhibiting the onset, and slowing the progression of erectile dysfunction including naturally occurring age related erectile dysfunction

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Medical Hypotheses (1994) 43, 339~342

Also Published As

Publication number Publication date
IL265571B (en) 2022-03-01
EP3518951A1 (en) 2019-08-07
CN110087664B (zh) 2022-11-01
US10426812B2 (en) 2019-10-01
US20180104300A1 (en) 2018-04-19
AU2017336916A1 (en) 2019-04-18
ES2971281T3 (es) 2024-06-04
EP3518951A4 (en) 2020-05-27
JP2019529569A (ja) 2019-10-17
EP3518951B1 (en) 2024-01-10
WO2018064469A1 (en) 2018-04-05
US20200215146A1 (en) 2020-07-09
EP3518951C0 (en) 2024-01-10
KR20190061045A (ko) 2019-06-04
IL265571A (en) 2019-05-30
CN110087664A (zh) 2019-08-02
US20190381124A1 (en) 2019-12-19
JP7075136B2 (ja) 2022-05-25
US10792324B2 (en) 2020-10-06

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