KR102470497B1 - 신경계 및 신경변성 질환을 치료하기 위한 5,7-디히드로-피롤로-피리딘 유도체 - Google Patents
신경계 및 신경변성 질환을 치료하기 위한 5,7-디히드로-피롤로-피리딘 유도체 Download PDFInfo
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- KR102470497B1 KR102470497B1 KR1020197002851A KR20197002851A KR102470497B1 KR 102470497 B1 KR102470497 B1 KR 102470497B1 KR 1020197002851 A KR1020197002851 A KR 1020197002851A KR 20197002851 A KR20197002851 A KR 20197002851A KR 102470497 B1 KR102470497 B1 KR 102470497B1
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Classifications
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- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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Landscapes
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- Endocrinology (AREA)
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Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662357624P | 2016-07-01 | 2016-07-01 | |
| US62/357,624 | 2016-07-01 | ||
| US201662372421P | 2016-08-09 | 2016-08-09 | |
| US62/372,421 | 2016-08-09 | ||
| PCT/IB2017/053565 WO2018002760A1 (en) | 2016-07-01 | 2017-06-15 | 5,7-dihydro-pyrrolo-pyridine derivatives for treating neurological and neurodegenerative diseases |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| KR20190035713A KR20190035713A (ko) | 2019-04-03 |
| KR102470497B1 true KR102470497B1 (ko) | 2022-11-23 |
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| EP (2) | EP3872078A1 (enExample) |
| JP (1) | JP7046018B2 (enExample) |
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| DK (1) | DK3478679T3 (enExample) |
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| SG (1) | SG11201811712QA (enExample) |
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| FI3642202T3 (fi) * | 2017-06-22 | 2023-03-01 | Dihydro-pyrrolo-pyridiinijohdannaisia | |
| WO2020087031A1 (en) | 2018-10-26 | 2020-04-30 | The Research Foundation For The State University Of New York | Combination serotonin specific reuptake inhibitor and serotonin 1a receptor partial agonist for reducing l-dopa-induced dyskinesia |
| EP4061813B1 (en) | 2019-11-22 | 2025-06-04 | F. Hoffmann-La Roche AG | Pyrrolidine derivatives |
| CA3174675A1 (en) * | 2020-04-29 | 2021-11-04 | Relay Therapeutics, Inc. | Pi3k.alpha. inhibitors and methods of use thereof |
| CN112174869B (zh) * | 2020-10-12 | 2023-04-25 | 蔡霈 | N-苯乙酰基-2-羟甲基吡咯烷-2-甲酰胺的制备方法及其药用用途 |
| JP2023549738A (ja) * | 2020-10-30 | 2023-11-29 | １シーバイオ， インコーポレイテッド | エクトヌクレオチドピロホスファターゼ－ホスホジエステラーゼ－１（ｅｎｐｐ１）阻害物質及びそれらの使用 |
| WO2022235514A1 (en) * | 2021-05-04 | 2022-11-10 | Mind Medicine, Inc. | Liposome delivery of psychedelics |
| CN120677153A (zh) * | 2022-09-23 | 2025-09-19 | 赛尔维治疗有限责任公司 | Emraclidine的晶型及其制备方法和用途 |
| JP2025534061A (ja) * | 2022-10-28 | 2025-10-09 | 紐欧申医薬（上海）有限公司 | 窒素含有複素環化合物、その薬学的に許容される塩及びその調製方法と使用 |
| KR20250121123A (ko) | 2022-12-16 | 2025-08-11 | 카루나 세러퓨틱스 인코포레이티드 | 치환된 테트라히드로피롤로-피리디논 화합물 및 의학적 병태를 치료하는 데 있어서의 이의 용도 |
| CN120641421A (zh) * | 2022-12-16 | 2025-09-12 | 卡鲁娜治疗学有限公司 | 经取代的二氢吡咯并[3,4-d]嘧啶化合物及其在治疗医学病状中的用途 |
| WO2024130065A1 (en) * | 2022-12-16 | 2024-06-20 | Karuna Therapeutics, Inc. | Substituted dihydropyrrolo[3, 4-d]pyrimidine compounds and their use in treating medical conditions |
| KR20250130620A (ko) * | 2022-12-16 | 2025-09-02 | 카루나 세러퓨틱스 인코포레이티드 | 치환된 테트라하이드로피롤로-피리디논 화합물 및 의학적 병태 치료에서의 이의 용도 |
| WO2024230794A1 (zh) * | 2023-05-11 | 2024-11-14 | 中国药科大学 | 氮杂环丁烷衍生物、其制备方法及其医药用途 |
| CN116693437A (zh) * | 2023-06-15 | 2023-09-05 | 安徽大学 | 一种N-Boc-3-氮杂环丁烷乙酸的合成方法 |
| WO2024260386A1 (zh) * | 2023-06-20 | 2024-12-26 | 西藏海思科制药有限公司 | 毒蕈碱m4受体激动剂及其用途 |
| WO2025055965A1 (zh) * | 2023-09-13 | 2025-03-20 | 中国药科大学 | 氮杂环丁烷衍生物、其制备方法及其医药用途 |
| WO2025055970A1 (zh) * | 2023-09-15 | 2025-03-20 | 江苏恩华药业股份有限公司 | 氮杂环丁烷衍生物、其制备方法及其医药用途 |
| WO2025083630A1 (en) | 2023-10-19 | 2025-04-24 | Suven Life Sciences Limited | Heteroaromatic compounds as muscarinic m4 receptor positive allosteric modulators (m4 pams) |
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