KR102397783B1 - Pd-l1 결합 폴리펩티드에 의한 pet 영상화 - Google Patents

Pd-l1 결합 폴리펩티드에 의한 pet 영상화 Download PDF

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KR102397783B1
KR102397783B1 KR1020187037833A KR20187037833A KR102397783B1 KR 102397783 B1 KR102397783 B1 KR 102397783B1 KR 1020187037833 A KR1020187037833 A KR 1020187037833A KR 20187037833 A KR20187037833 A KR 20187037833A KR 102397783 B1 KR102397783 B1 KR 102397783B1
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KR20190015376A (ko
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폴 이. 모린
데이비드 도넬리
다사 리포브세크
요켐 고케메이예르
마리아 주르-쿤켈
데이비드 파브리지오
마틴 씨. 라이트
더글라스 디쉬노
사무엘 제이. 보나코르시
랄프 애덤 스미스
비르지니 라퐁
다니엘 코헨
데이비드 케이. 릉
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브리스톨-마이어스 스큅 컴퍼니
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/088—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins conjugates with carriers being peptides, polyamino acids or proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/041—Heterocyclic compounds
    • A61K51/044—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K51/0455—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B59/00—Introduction of isotopes of elements into organic compounds ; Labelled organic compounds per se
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2123/00—Preparations for testing in vivo

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Optics & Photonics (AREA)
  • Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
KR1020187037833A 2016-06-01 2017-05-31 Pd-l1 결합 폴리펩티드에 의한 pet 영상화 Active KR102397783B1 (ko)

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US201662344258P 2016-06-01 2016-06-01
US62/344,258 2016-06-01
PCT/US2017/035227 WO2017210302A1 (en) 2016-06-01 2017-05-31 Pet imaging with pd-l1 binding polypeptides

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KR102397783B1 true KR102397783B1 (ko) 2022-05-12

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US (2) US11344639B2 (enExample)
EP (1) EP3463486A1 (enExample)
JP (1) JP7016323B2 (enExample)
KR (1) KR102397783B1 (enExample)
CN (1) CN109562195A (enExample)
WO (1) WO2017210302A1 (enExample)

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KR102397783B1 (ko) 2016-06-01 2022-05-12 브리스톨-마이어스 스큅 컴퍼니 Pd-l1 결합 폴리펩티드에 의한 pet 영상화
EP3630838A1 (en) 2017-06-01 2020-04-08 CytomX Therapeutics, Inc. Activatable anti-pdl1 antibodies, and methods of use thereof
US20200405890A1 (en) * 2018-02-21 2020-12-31 Cytomx Therapeutics, Inc. Positron emission tomography imaging of activatable binding polypeptides and related compositions thereof
WO2019228514A1 (en) 2018-06-01 2019-12-05 Tayu Huaxia Biotech Medical Group Co., Ltd. Compositions and uses thereof for treating disease or condition
WO2019227490A1 (en) * 2018-06-01 2019-12-05 Tayu Huaxia Biotech Medical Group Co., Ltd. Compositions and methods for imaging
WO2020151572A1 (en) 2019-01-23 2020-07-30 Tayu Huaxia Biotech Medical Group Co., Ltd. Anti-pd-l1 diabodies and the use thereof
CN110746493A (zh) * 2019-09-06 2020-02-04 中国药科大学 一种pd-l1拮抗剂多肽及其应用
CN111116595A (zh) * 2019-12-30 2020-05-08 福建医科大学附属第一医院 以tspo为靶点的放射性分子探针及其制备方法和应用
CN116568341A (zh) 2020-02-28 2023-08-08 百时美施贵宝公司 基于纤连蛋白的放射性标记的支架和抗体及其治疗诊断用途
EP4138858A4 (en) * 2020-04-21 2024-07-03 Flagship Pioneering, Inc. BIFUNCTIONAL MOLECULES AND METHODS OF USE THEREOF
WO2022028557A1 (zh) * 2020-08-07 2022-02-10 上海再极医药科技有限公司 18f标记的联苯类化合物、其中间体、制备方法、药物组合物及应用
CN114057589B (zh) * 2020-08-07 2025-05-23 上海再极医药科技有限公司 18f标记的联苯类化合物、其中间体、制备方法、药物组合物及应用
US20250135047A1 (en) * 2021-08-06 2025-05-01 The Johns Hopkins University Improved aluminum fluoride radiosynthesis of [18f]dk222

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KR20190015376A (ko) 2019-02-13
WO2017210302A1 (en) 2017-12-07
CN109562195A (zh) 2019-04-02
JP7016323B2 (ja) 2022-02-21
US20190184042A1 (en) 2019-06-20
US20220347324A1 (en) 2022-11-03
EP3463486A1 (en) 2019-04-10
US11344639B2 (en) 2022-05-31
JP2019525891A (ja) 2019-09-12

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