KR102392893B1 - 신규한 cyp-아이코사노이드 유도체 - Google Patents

신규한 cyp-아이코사노이드 유도체 Download PDF

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KR102392893B1
KR102392893B1 KR1020167022894A KR20167022894A KR102392893B1 KR 102392893 B1 KR102392893 B1 KR 102392893B1 KR 1020167022894 A KR1020167022894 A KR 1020167022894A KR 20167022894 A KR20167022894 A KR 20167022894A KR 102392893 B1 KR102392893 B1 KR 102392893B1
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alkyl
fluorine
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KR20160111988A (ko
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불프-하겐 슌크
불프-하겐 šœ크
도미닉 뮬러
로버트 피셔
제드 발루캇
안느 콘넬
존 러셀 폴크
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막스-델부뤽-센트럼 퓌어 몰레쿨라레 메디친 인 데어 헬름홀츠-게마인샤프트
더 보드 오브 리젠츠 오브 더 유니버시티 오브 텍사스 시스템
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    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
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    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/3804—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)] not used, see subgroups
    • C07F9/3826—Acyclic unsaturated acids
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
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    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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    • C07C309/02—Sulfonic acids having sulfo groups bound to acyclic carbon atoms
    • C07C309/20—Sulfonic acids having sulfo groups bound to acyclic carbon atoms of an acyclic unsaturated carbon skeleton
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    • C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C311/16—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom
    • C07C311/18—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom to an acyclic carbon atom of a hydrocarbon radical substituted by nitrogen atoms, not being part of nitro or nitroso groups
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    • C07C323/32—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton having at least one of the nitrogen atoms bound to an acyclic carbon atom of the carbon skeleton
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    • C07C323/39—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton at least one of the nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom
    • C07C323/40—Y being a hydrogen or a carbon atom
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    • C07D277/62—Benzothiazoles
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    • C07F9/4003—Esters thereof the acid moiety containing a substituent or a structure which is considered as characteristic
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  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
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  • Thiazole And Isothizaole Compounds (AREA)
KR1020167022894A 2014-01-22 2015-01-21 신규한 cyp-아이코사노이드 유도체 Active KR102392893B1 (ko)

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US201461930031P 2014-01-22 2014-01-22
US61/930,031 2014-01-22
PCT/EP2015/000105 WO2015110262A1 (en) 2014-01-22 2015-01-21 Novel cyp-eicosanoid derivatives

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JP6636133B2 (ja) * 2015-07-22 2020-01-29 オメイコス セラピューティクス ゲーエムベーハー 心疾患の治療に対するｃｙｐ−エイコサノイドの代謝的にロバストな類縁体
CN109562083A (zh) * 2016-04-01 2019-04-02 奥迈科斯治疗公司 用于治疗或预防与新血管形成和/或炎症相关疾病的cyp-类二十烷酸类似物
BR112018070194A2 (pt) * 2016-04-01 2019-01-29 Max Delbrueck Centrum Fuer Molekulare Medizin composto e composição para uso
US10562849B2 (en) * 2016-05-16 2020-02-18 The Board Of Regents Of The University Of Texas System Cationic sulfonamide amino lipids and amphiphilic zwitterionic amino lipids
WO2023094615A1 (en) 2021-11-26 2023-06-01 Omeicos Therapeutics Gmbh Synthetic eicosanoid analogues for the treatment and prevention of diseases associated with increased gdf15 plasma concentration

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CA2934964C (en) 2022-03-01
DK3097076T3 (da) 2019-07-29
CN110950786A (zh) 2020-04-03
RU2016133336A3 (enExample) 2018-08-10
BR112016016139B1 (pt) 2023-04-25
KR20160111988A (ko) 2016-09-27
CY1122591T1 (el) 2021-01-27
SI3097076T1 (sl) 2019-10-30
JP6577951B2 (ja) 2019-09-18
BR112016016139A2 (enExample) 2017-08-08
EP3097076B1 (en) 2019-05-08
WO2015110262A1 (en) 2015-07-30
CN106061942A (zh) 2016-10-26
MX2016009507A (es) 2017-03-15
HRP20191315T1 (hr) 2019-10-18
JP2017505313A (ja) 2017-02-16
CN106061942B (zh) 2019-11-15
RS59218B1 (sr) 2019-10-31
US20170008918A1 (en) 2017-01-12
RU2730512C2 (ru) 2020-08-24
RU2016133336A (ru) 2018-02-28
EP3097076A1 (en) 2016-11-30
LT3097076T (lt) 2019-08-26
US11130772B2 (en) 2021-09-28
HUE044703T2 (hu) 2019-11-28
PT3097076T (pt) 2019-07-30
CA2934964A1 (en) 2015-07-30
MX368689B (es) 2019-10-11
AU2015208416A1 (en) 2016-08-11
ES2738701T3 (es) 2020-01-24
SMT201900438T1 (it) 2019-09-09
PL3097076T3 (pl) 2019-10-31
AU2015208416B2 (en) 2017-11-30

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