KR102372661B1 - Method for producing effervescent tablet containing sprout oat - Google Patents

Abstract

Disclosed is a method for manufacturing an effervescent tablet containing sprout oats, which can be easily ingested as an active ingredient of sprout oats by processing sprout oats by a specific processing method and then manufacturing the same into effervescent tablets. The method for manufacturing the effervescent tablet containing sprout oats is provided. The method for manufacturing effervescent tablet includes the following steps: immersing the pre-treated sprout oats in lower alcohol having 1 to 5 carbon atoms to elute the active ingredient; recovering the active ingredient and then mixing the same with vitamin D, a foaming agent, a dispersing agent, an extender, and other ingredients to manufacture an effervescent tablet precursor; and tableting the effervescent tablet precursor using a tableting machine.

Description

Effervescent tablet manufacturing method containing sprout oats {Method for producing effervescent tablet containing sprout oat}

The present invention relates to a method for producing effervescent tablets containing sprouted oats, and more particularly, by processing sprouted oats by a specific processing method and then manufacturing them into effervescent tablets, sprouts that can easily ingest the active ingredients of sprouted oats It relates to a method for manufacturing an effervescent tablet comprising oats.

The prevalence of various lifestyle-related diseases and chronic degenerative diseases due to overnutrition, environmental pollution, lack of exercise, and increased stress caused by the improvement of the economic level is emerging as a big problem in our society. Among them, obesity is a disease that has recently attracted the most attention.

In obesity, energy intake from food is generally out of balance with energy expenditure due to physical activity, so the surplus energy causes an increase in the quantity and number of adipocytes in the body. It means a state in which tissues are excessively accumulated, and it refers to a disease caused by the breakdown of energy balance in the human body due to genetic factors, environmental factors, mental factors, or lifestyle habits such as eating habits and lack of exercise.

The World Health Organization (WHO) has already recognized obesity as a disease to be treated and has treated it as a global nutritional problem (World Health Organization (1998)). Currently, the number of obese patients is continuously increasing, and the World Health Organization recently reported that more than 1 billion adults worldwide are overweight, and at least 300 million of them are obese. In addition, according to the 2007 National Health and Nutrition Survey data in Korea announced by the Ministry of Health and Welfare, the number of obese people with a body mass index (BMI) of 25 or more is steadily increasing, and the public health is seriously threatened (Ministry of Health and Welfare (2007) )).

The obesity is particularly high in morbidity and mortality compared to other diseases, and has been found to be related to complications of various adult diseases. For example, it has been reported that obese patients are twice as likely to have liver disease, 1.6 times as for cerebrovascular disease, and 1.8 times as for coronary artery disease, compared to those of normal weight. Currently, various drug therapies including diet, exercise, and diuretics, laxatives, etc. have been tried, but their use is limited temporarily and limitedly due to side effects such as nutritional imbalance, reduced immunity, and depression.

In relation to the obesity, studies on localization (Adipogensis) are in progress. The localization refers to a process in which adipocytes are differentiated from pre-adipocytes to accumulate fat, and the localization is known to cause metabolic diseases such as obesity, diabetes, fatty liver and coronary heart disease. The fat cells perform various functions for maintaining body energy homeostasis by secreting a protein hormone called adipocytokine as an endocrine organ as well as simply serving as an energy store.

However, excessive differentiation of adipocytes and unbalanced energy metabolism results in abnormal gene expression and signal transduction system abnormality in adipocytes, which causes abnormalities in lipid targets as well as metabolic diseases such as obesity.

Obesity treatment mechanisms for resolving the obesity and maintaining an appropriate body weight include control of appetite, interference with digestion and absorption of fat, increase in energy consumption, regulation of lipid metabolism, and the like. Currently commonly used anti-obesity drugs are drugs that inhibit the activity of serotonin and lipolytic enzymes to prevent hydrolysis of cholesterol and triglycerides and help excretion of unoxidized fat into feces. orlistat (XenicalR).

However, in the case of serotonin, it should be used with caution in patients with cardiovascular disease by raising blood pressure, and in the case of orlistat, it is reported that it induces digestive disorders, fatty stools, defecation incontinence, and interference with absorption of fat-soluble vitamins. In some cases, it has been reported to have significant side effects.

On the other hand, oat leaves have been used as medicines from the old days and have been known to be rich in nutrients such as vitamins, enzymes, and chlorophyll. Recently, as the effects of excellent nutritional components and health functional substances contained in oats on a balanced diet, improvement of constitution, etc. are known, interest as a health functional raw material crop is increasing, and it is also being evaluated excellently for livestock feed.

Sprout oats refer to young plants that have sprouted and grown to about 15 cm. Usually, after soaking the oats in water for a day or so, drain the water, and spread the oats in a plastic basket or Styrofoam of an appropriate size and sowing the oats. Cover it with paper until it sprouts, remove it when it sprouts, and use it when it reaches a size of 15cm after 7-10 days while maintaining moisture. It is known that the sprouted oats contain dietary fiber, carotene, vitamin C, and the like, in a significantly higher content than other vegetables and fruits. In addition, in terms of pharmacological activity, the sprout oats are known to exhibit effects such as lowering cholesterol, preventing constipation, preventing arteriosclerosis, antioxidant activity, anti-aging, preventing osteoporosis, improving insomnia, and preventing anemia.

Therefore, it inhibits the growth and differentiation of mast cells among natural products that are expected to relatively minimize the possibility of safety problems, and thus has a high anti-obesity effect on obesity caused by excess adipose tissue or abnormal fat metabolism. There is a demand for the development of anti-obesity drugs with minor side effects.

(0001) Republic of Korea Patent Registration No. 10-1540737 (0002) Republic of Korea Patent Publication No. 10-2019-0136728

The present invention has been devised to solve the above problems, and an object of the present invention is to produce sprout oats having an effect on the treatment of obesity through a specific method. It is to provide a method for manufacturing effervescent tablets containing sprouted oats having improved obesity suppression effect.

Another object of the present invention is to provide a method for manufacturing an effervescent tablet containing sprouted oats, which is easier to consume as compared to conventional sprouted oats by manufacturing an effervescent tablet using the sprouted oats and has an improved absorption effect.

The problems of the present invention are not limited to the problems mentioned above, and other problems not mentioned will be clearly understood by those skilled in the art from the following description.

The present invention for solving the above problems provides a method for producing an effervescent tablet containing sprouted oats.

In one embodiment, the manufacturing method of the effervescent tablet comprises the steps of immersing the pre-treated sprouted oats in lower alcohol having 1 to 5 carbon atoms to elute the active ingredient; recovering the active ingredient and then mixing it with vitamin D, a foaming agent, a dispersing agent, an extender and other ingredients to prepare an effervescent tablet precursor; and tableting the effervescent tablet precursor using a tableting machine.

In one embodiment, the pre-treated sprout oats, drying the washed sprout oats to less than 5% by weight of moisture content; expanding the dried sprouted oats at a temperature of 200 to 250° C. using a expander; And it may be prepared by a method comprising the step of powdering the swollen sprout oats.

In one embodiment, the step of eluting the active ingredient, immersing the powdered sprout oats in lower alcohol having 1 to 5 carbon atoms; supplying ultrasonic waves to the sprouted oats immersed in the lower alcohol and eluting the active ingredient; and separating the active ingredient through a method consisting of a solvent decomposition method, a chromatographic fractionation method, an ultrafiltration fractionation method, or a combination thereof.

In one embodiment, the step of preparing the effervescent tablet precursor includes vitamin D, a foaming agent, a sustained-release agent, a dispersant, citric acid, nicotianamide, zinc, calcium carbonate, pantothenic acid, maltitol, flavoring, and denaturation in the separated active ingredients. It can be prepared by mixing starch, natural colorants, stevia, acesulfame potassium, sucralose, and calcium or potassium phosphate.

In one embodiment, the pre-treated sprout oats, immersing oat seeds in water for 10 to 120 minutes, then separating the water and seeds; After immersing half of the separated oat seeds submerged, sprouting for 10 to 30 hours at a temperature of 10 to 30 ℃; arranging the sprouted oats to form one layer, and then placing a porous plate with a diameter of 2-5 mm on top of the oat layer; supplying water to the oats in units of 10 to 20 hours; Harvesting when the sprouted oats grown on the upper portion of the porous plate reach 10 to 20 cm; charging the harvested sprouted oats into a dryer, then replacing the inside with an inert gas and drying at a temperature of 60 to 80° C. with a moisture content of less than 5% by weight; charging the dried sprouted oats into the expander, then substituting the inside with an inert gas and swelling using a temperature of 200 to 250° C. and a pressure of 1 to 3 Mpa; And it is prepared by a method comprising the step of powdering the swollen sprout oats, and the step of eluting the active ingredient is 1 to 5 carbon atoms compared to 100 parts by weight of the powdered sprout oats to the powdered sprout oats. immersing the sprouted oat powder by supplying 150 to 200 parts by weight of lower alcohol; eluting the active ingredient by supplying ultrasonic waves having a frequency of 10 to 70 kHz to the immersed sprout oat powder at an intensity of 500 to 1000 W for 5 to 20 minutes; Separating the liquid component by filtration under reduced pressure after the elution is completed; and vacuum-concentrating the liquid component and freeze-drying to prepare an active ingredient extract for sprout oats, wherein the method for preparing the effervescent tablet precursor is to mix 400 to 600 parts by weight of water with 100 parts by weight of the active ingredient for sprout oats to dissolve; adding 100 parts by weight of zeolite having an average diameter of 30 to 100 nm to the active ingredient of sprouted oat dissolved in water to adsorb the active ingredient of sprouted oat into the pores of the zeolite; Preparing a foaming agent coated with sugar by mixing 80 to 90 parts by weight of sodium bicarbonate and 10 to 20 parts by weight of sugar using a fluidized bed granulation dryer; And 10-20 parts by weight of active ingredient powder of sprout oats, 0.1-0.5 parts by weight of vitamin D, 20-30 parts by weight of a foaming agent coated with sugar, 5-10 parts by weight of zeolite with active ingredient adsorbed, potassium dibasic 0.1- 2 parts by weight, 20-30 parts by weight of citric acid powder, 0.1-0.5 parts by weight of nicotinic acid amide, 0.1-0.5 parts by weight of zinc, 1-10 parts by weight of calcium carbonate, 0.1-0.5 parts by weight of pantothenic acid, 5-10 parts by weight of maltitol, fragrance 1 to 5 parts by weight, 0.5 to 1 parts by weight of modified starch, 0.1 to 1 parts by weight of dye, 0.1 to 0.5 parts by weight of stevia, 0.1 to 0.5 parts by weight of acesulfame potassium, and 0.1 to 0.5 parts by weight of sucralose to prepare an effervescent tablet precursor It may include a manufacturing step.

The present invention also provides an effervescent tablet of oat sprouts prepared by the above manufacturing method.

According to an embodiment of the present invention, as sprouted oats are processed using a specific method and active ingredients are extracted, the active ingredient content can be higher than that of the conventional manufacturing method, and accordingly, the composition containing sprouted oats Compared to that, it can have a high anti-obesity effect.

In addition, by impregnating the active ingredient in porous sustained-release formulation, the release of the active ingredient that exerts an anti-obesity effect can be sustained for a long time. can do.

In addition, by manufacturing an effervescent tablet using the sprout oat powder as described above, it is possible to provide a method for manufacturing an effervescent tablet containing sprout oat, which is easier to ingest than a formulation containing an active ingredient in sprout oat powder.

The effect according to the present invention is not limited by the contents exemplified above, and more various effects are included in the present invention.

1 schematically shows a method for manufacturing an effervescent tablet containing sprouted oats according to an embodiment of the present invention.
Figure 2 shows a photograph of sprouted oats grown according to an embodiment of the present invention.
3 is a photograph showing the active ingredient extract of sprout oats according to an embodiment of the present invention.
Figure 4 shows a photograph of an effervescent tablet containing sprouted oats according to an embodiment of the present invention.

Hereinafter, various embodiments will be described in more detail with reference to the accompanying drawings. The embodiments described herein may be variously modified. Certain embodiments may be depicted in the drawings and described in detail in the detailed description. However, the specific embodiments disclosed in the accompanying drawings are only provided to facilitate understanding of the various embodiments. Therefore, the technical idea is not limited by the specific embodiments disclosed in the accompanying drawings, and it should be understood to include all equivalents or substitutes included in the spirit and scope of the invention.

Terms including an ordinal number such as 1st, 2nd, etc. may be used to describe various components, but these components are not limited by the above-mentioned terms. The above terminology is used only for the purpose of distinguishing one component from another component.

In this specification, terms such as "comprises" or "have" are intended to designate that the features, numbers, steps, operations, components, parts, or combinations thereof described in the specification exist, but one or more other features It should be understood that this does not preclude the existence or addition of numbers, steps, operations, components, parts, or combinations thereof. When an element is referred to as being “connected” or “connected” to another element, it is understood that it may be directly connected or connected to the other element, but other elements may exist in between. it should be On the other hand, when it is said that a certain element is "directly connected" or "directly connected" to another element, it should be understood that the other element does not exist in the middle.

Meanwhile, as used herein, a “module” or “unit” for a component performs at least one function or operation. And “module” or “unit” may perform a function or operation by hardware, software, or a combination of hardware and software. In addition, a plurality of “modules” or a plurality of “units” other than a “module” or “unit” to be performed in specific hardware or to be executed in at least one processor may be integrated into at least one module. The singular expression includes the plural expression unless the context clearly dictates otherwise.

In addition, in describing the present invention, if it is determined that a detailed description of a related known function or configuration may unnecessarily obscure the gist of the present invention, the detailed description thereof will be abbreviated or omitted.

The present invention relates to a method for manufacturing an effervescent tablet containing sprouted oats.

The sprouted oats of the present invention are sprouted from oats and grown up to a certain length, and the leaf parts of these sprouted oats are collected. In general, oats are cultivated for 5 to 15 days to collect the shoots, and the cultivation time may vary depending on the ambient temperature and moisture content and sunlight.

In the case of the sprouted oats of the present invention, various active ingredients may be included. Through this, the sprout oats may have an effect of inhibiting the differentiation of mast cells, and thus may have an effect on suppressing obesity. In addition, as the sprout oats contain a large amount of polyphenol components, it can help improve atopic dermatitis.

To this end, the sprouted oats are dried to less than 5% by weight of the washed sprouted oats; expanding the dried sprouted oats at a temperature of 200 to 250° C. using a expander; And it may be prepared by a method comprising the step of powdering the swollen sprout oats.

The step of immersing the sprouted oat seeds in water for 10 to 120 minutes, and then separating the seeds from the water; After immersing half of the separated oat seeds submerged, sprouting for 10 to 30 hours at a temperature of 10 to 30 ℃; arranging the sprouted oats to form one layer, and then placing a porous plate with a diameter of 2-5 mm on top of the oat layer; supplying water to the oats in units of 10 to 20 hours; When the sprouted oats grown to the upper part of the porous plate reach 10 to 20 cm, they can be cultivated through a step of harvesting them.

It is preferable to use the oat seeds that are not milled after threshing the oats, and those commonly sold as top oats may be used. When the milling of the oat seed is performed, the hull of the surface of the oat seed may be peeled off, and the germination rate may be reduced, and the growth rate may be reduced during cultivation because the oat seed may be contaminated during cultivation.

The oat seeds prepared as described above may be immersed in water for 10 to 120 minutes to supply moisture. As described above, the minimum water required for germination can be supplied through the immersion process, and thus the germination of oat seeds can be started. In this case, when the immersion is less than 10 minutes, the water required for germination of the oat seeds may not be supplied, and the germination rate may decrease.

When the immersion process as described above is completed, the water and seeds can be separated. By separating the water and the seed, foreign substances adhering to the surface of the seed can be removed, and thus the germination rate can be increased.

The seed separated from the water may be germinated by immersion in water so that half of the seed is submerged. To this end, the seeds may be arranged in one layer on a wide plate, and water may be constantly supplied to the surface of the plate to promote germination of the seeds. In addition, in this step, it is preferable to cover the surface of the seed with an opaque polymer film to prevent evaporation of moisture and block light in a certain portion. The germination step may be a step of sprouting for 10 to 30 hours at a temperature of 10 to 30 ℃. At this time, if the temperature is less than 10 ℃ or less than 10 hours, germination may not occur, and if the temperature exceeds 30 degrees or sprouts for more than 30 hours, the seeds will rot or a lot of time has passed after germination, so a porous plate to be described later can be difficult to use. In addition, at this time, the water in which the oat seeds are immersed may contain various nutrients for germination. These nutrients not only serve to assist the germination of the seeds, but are also absorbed into the seeds during germination of the seeds, thereby enhancing the nutritional components of seeds and sprouted oats. These nutrients include nitrogen compounds, phosphorus compounds, GABA, red ginseng extract, ginseng extract, green tea extract, vitamins, magnesium, zinc, iron, sodium, selenium, etc. It may include a component capable of fortifying the nutritional component.

Seeds germinated as described above are arranged to form one layer, so that sprouts can be grown. In this case, a porous plate may be disposed on the upper portion of the oat layer for smooth growth of the sprout and the ease of harvesting the sprout.

The porous plate may be positioned on top of the oat seed to allow the sprout to grow through the porous plate. In this case, if the perforation of the porous plate is adjusted, the oat seed may not pass through, but only the sprout may grow to the upper part of the porous plate. Through this, it can be easily separated from the oat seed when the sprout oats are harvested, and it is possible to prevent excess moisture from coming into contact with the sprout part. To this end, the porous plate may be perforated with a diameter of 2 to 5 mm. If the perforation size of the porous plate is less than 2 mm, it is difficult for sprouted oats to grow through the porous plate.

The oat seeds arranged as described above are harvested when the length of the sprout reaches 10 to 20 cm. In the case of conventional sprouted oats, sprouted oats are harvested from the cultivation area, and then the sprouted part is cut and recovered. Optimum harvest of sprouted oats is possible as the mixing of oat seeds and extra moisture is minimized.

The sprouted oats harvested as described above may be subjected to a pretreatment process.

The pretreatment process is a process performed to maximize the elution of the active ingredient of the sprouted oats, and the harvested sprouted oats are charged in a dryer, then the inside is replaced with an inert gas, and the moisture content is 5 weight at a temperature of 60~80℃ drying to less than %; charging the dried sprouted oats into the expander, then substituting the inside with an inert gas and swelling using a temperature of 200 to 250° C. and a pressure of 1 to 3 Mpa; And it may include the step of pulverizing the expanded sprout oats.

The harvested sprouted oats may be charged in a dryer and then subjected to a drying process. In this drying process, in order to prevent oxidation and deterioration of the sprouted oats, the inside of the dryer is preferably substituted with an inert gas. In this case, nitrogen, helium, neon, argon, or xenon may be used as the inert gas used, and it is preferable to use nitrogen, which is easy to handle and inexpensive.

In addition, the drying process is preferably dried at a temperature of 60 ~ 80 ℃ moisture content of less than 5% by weight. When the temperature in the dryer is less than 60 ℃, it is not economical because a lot of time required for drying is required, and when the temperature exceeds 80 ℃, thermal decomposition occurs and the amount of the recovered active ingredient may be reduced. In addition, when the moisture content exceeds 5% by weight, it may be difficult to deteriorate or powder in a subsequent process.

After the dried sprout oats are charged into the expander, the inside is replaced with an inert gas and can be swollen using a temperature of 200 to 250° C. and a pressure of 1 to 3 Mpa. In the case of the existing sprouted oat powder, it is simply dried and then powdered to produce a product. However, in this case, the elution of the active ingredient located in the sprouted oat cells is not complete, and the absorption capacity of the human body is also low, so there is a limit to its utilization. In the case of the present invention, it is possible to break the cell wall structure of the sprouted oats by swelling the dried sprouted oats, and thus can have a higher elution amount of the active ingredient.

The swelling step may be performed after replacing the inside with an inert gas. Since the swelling step is performed in an environment of high temperature and high pressure, the active ingredient may be oxidized and deteriorated when in contact with oxygen. Therefore, in order to minimize the deterioration due to the oxidation, it is preferable to perform the expansion after replacing the inside of the expander with an inert gas. In this case, nitrogen, helium, neon, argon, or xenon may be used as the inert gas used, and it is preferable to use nitrogen, which is easy to handle and inexpensive.

In addition, the swelling step may be performed using a temperature of 200 ~ 250 ℃ and a pressure of 1 ~ 3Mpa. If the temperature is less than 200 ℃ or is carried out at a pressure of less than 1 Mpa, the swelling is not smooth, and when the temperature exceeds 250 ℃ or is carried out at a pressure exceeding 3 Mpa, the rutonarin and saponarin components are altered due to excessive heat and pressure can be

Sprouts of sprouted oats as described above may be powdered. At this time, if the powdering is a method capable of powdering the dried and swollen sprout oats to a certain size, it can be powdered using without limitation, but preferably using a ball mill.

As described above, the powdered sprouted oats may be included in the effervescent tablet as it is, but the active ingredient may be eluted and included in the effervescent tablet to increase absorption.

To this end, supplying 150 to 200 parts by weight of a lower alcohol having 1 to 5 carbon atoms compared to 100 parts by weight of the powdered sprout oats to the powdered sprout oats and immersing the sprout oat powder; eluting the active ingredient by supplying ultrasonic waves having a frequency of 10 to 70 kHz to the immersed sprout oat powder at an intensity of 500 to 1000 W for 5 to 20 minutes; Separating the liquid component by filtration under reduced pressure after the elution is completed; and vacuum-concentrating the liquid component and freeze-drying to prepare an active ingredient extract of sprout oats.

The lower alcohol means a lower alcohol having 1 to 5 carbon atoms, and includes methanol, ethanol, propanol, butanol, pentanol, ethanediol, protandiol, butanediol, pentanediol, glycerin, butanetriol, pentanetriol, and the like. It can be used, preferably ethanol can be used. In this case, the lower alcohol included may be used in an amount of 150 to 200 parts by weight compared to 100 parts by weight of sprout oats. When the lower alcohol is included in less than 150 parts by weight, dissolution of the active ingredient may not be complete, and when it exceeds 200 parts by weight, economic efficiency may be deteriorated as a large amount of the lower alcohol is used.

Ultrasound having a frequency of 10 to 70 kHz may be supplied to the sprouted oat powder immersed in the lower alcohol at an intensity of 500 to 1000 W for 5 to 20 minutes. Although the sprouted oat powder is in a state in which many cell walls are pulverized through the swelling process, it is preferable to further decompose these cell walls through an additional process. In the case of the present invention, cellulose, which is the main component of the cell wall, is decomposed using ultrasonic waves, and thus it can have a higher elution amount of active ingredients compared to conventional sprouted oat powder.

In the case of the ultrasonic wave, since the cellulose is decomposed through a resonance phenomenon, it may have a frequency of 10 to 70 kHz. When the frequency of the ultrasonic wave is out of the above range, decomposition of the cellulose cannot be performed. In addition, if the ultrasonic wave has an intensity of less than 500 W or is supplied for less than 5 minutes, the decomposition effect of the cellulose may be reduced. There is a possibility.

As described above, after the active ingredient is eluted using ultrasonic waves, the solid content can be separated by filtration under reduced pressure. At this time, the solid content is composed of the cellulose, fibers, and cell residues, and since the active ingredients, particularly rutonarin and saponarin, are dissolved in the lower alcohol, it can be separated through the reduced pressure filtration.

The active ingredient separated through the reduced pressure filtration may be vacuum-concentrated and then freeze-dried to prepare an active ingredient extract of sprout oat. In the case of the active ingredient of the sprout oat, as described above, it is weak to heat and may be deteriorated or thermally decomposed when heated for a long time. Therefore, in order to prevent such damage by heat, the active ingredient may be removed by vacuum concentration to remove a portion of the lower alcohol, and then may be powdered through freeze-drying.

It is preferable that the powdered oat sprout active ingredient extract is mixed with a foaming agent and the like to produce an effervescent tablet. In the case of the existing sprouted oat powder, it has a problem that it is difficult to ingest and store as it is simply manufactured as a powder. However, in the case of the present invention, it is possible to prepare an effervescent tablet of sprout oat that can be easily ingested by extracting only the active ingredient from the sprout oat powder and then purifying it.

To this end, mixing and dissolving 400 to 600 parts by weight of water in 100 parts by weight of the active ingredient of sprout oats; adding 100 parts by weight of zeolite having an average diameter of 30 to 100 nm to the active ingredient of sprouted oat dissolved in water to adsorb the active ingredient of sprouted oat into the pores of the zeolite; Preparing a foaming agent coated with sugar by mixing 80 to 90 parts by weight of sodium bicarbonate and 10 to 20 parts by weight of sugar using a fluidized bed granulation dryer; And 10-20 parts by weight of active ingredient powder of sprout oat, 0.1-0.5 parts by weight of vitamin D, 20-30 parts by weight of a foaming agent coated with sugar, 5-10 parts by weight of zeolite with active ingredient adsorbed, potassium dibasic phosphate 0.1- 2 parts by weight, 20-30 parts by weight of citric acid powder, 0.1-0.5 parts by weight of nicotinic acid amide, 0.1-0.5 parts by weight of zinc, 1-10 parts by weight of calcium carbonate, 0.1-0.5 parts by weight of pantothenic acid, 5-10 parts by weight of maltitol, fragrance 1 to 5 parts by weight, 0.5 to 1 parts by weight of modified starch, 0.1 to 1 parts by weight of dye, 0.1 to 0.5 parts by weight of stevia, 0.1 to 0.5 parts by weight of acesulfame potassium, and 0.1 to 0.5 parts by weight of sucralose to prepare an effervescent tablet precursor An effervescent tablet precursor can be prepared through the manufacturing step, and it can be manufactured into an effervescent tablet using a tableting machine.

Sprout oat active ingredient extract of the present invention does not simply include extract powder, but some extract powder is impregnated into a porous material, and the active ingredient is slowly released for a certain period of time, thereby increasing the absorption rate of the active ingredient. Existing sprouted oat extract powder simply contains extract powder, so the initial concentration may be high, but it is known that the concentration in the body decreases rapidly as it goes through the half-life. However, in the case of the present invention, by impregnating some sprout oat active ingredient extract into the porous material, the sprout oat active ingredient extract can be released over a certain period of time, thereby maintaining a certain concentration in the body for a long period of time, It can further enhance the anti-obesity effect.

To this end, mixing and dissolving 400 to 600 parts by weight of water in 100 parts by weight of the active ingredient of sprout oats; 100 parts by weight of zeolite having an average diameter of 30 to 100 nm is added to the active ingredient of sprouted oat dissolved in water to adsorb the active ingredient of sprouted oat into the pores of the zeolite.

The oat sprout active ingredient extract prepared by the vacuum concentration and freeze-drying may be dissolved in water and then adsorbed to the porous material. In this case, the amount of water used may be 400 to 600 parts by weight relative to 100 parts by weight of the active ingredient of sprout oats. When the water is included in less than 400 parts by weight, the concentration of the active ingredient extract of sprout oat is high, so that smooth adsorption is difficult.

In addition, as the porous material, a zeolite having an average diameter of 30 to 100 nm may be used. The zeolite is a type of reticulated silicate mineral and has pores having a size of several nanometers, so it can be used as a porous adsorbent. Activated carbon, which is widely used in food and medicine, can be used as such a porous adsorbent, but black effervescent tablets are manufactured due to the nature of activated carbon, and it is preferable to use zeolite because black foreign substances can be seen even when foamed in water. Do. In this case, the zeolite may have a size of 30 to 100 nm. In the case of having a size of less than 30 nm, the size of the particles is reduced compared to the size of the pores, so that the adsorption efficiency may be lowered.

100 parts by weight of this zeolite may be added to the active ingredient extract of sprout oats dissolved in the water. When the zeolite is added in the above ratio, it is possible to have an optimal adsorption efficiency.

The effervescent agent is a substance that is decomposed by generating a gas in contact with water, and can enable the effervescent tablet prepared in the form of a tablet by a tableting machine to be quickly and easily dissolved in water. However, since these foaming agents may foam even when in contact with moisture in the air, in order to prevent this, the surface of the foaming agent may be coated with sugar to block contact with moisture. For this, 80 to 90 parts by weight of sodium bicarbonate and 10 to 20 parts by weight of sugar are mixed using a fluidized bed granulation dryer to prepare a sugar-coated foaming agent. As the foaming agent, the sodium bicarbonate may be used, and it may be coated with sugar to prevent self-decomposition and foaming due to moisture in the air. In addition, the sugar can be used as a binder when compressed by a tableting machine, and when consumed by dissolving the effervescent tablet in water, it can be used as a sweetener to add sweetness, thereby facilitating ingestion.

The sprout oat active ingredient extract powder 10-20 parts by weight, vitamin D 0.1-0.5 parts by weight, sugar-coated foaming agent 20-30 parts by weight, zeolite 5-10 parts by weight with adsorbed sprout oat active ingredient, potassium dibasic 0.1 ~2 parts by weight, citric acid powder 20-30 parts by weight, nicotinic acid amide 0.1-0.5 parts by weight, zinc 0.1-0.5 parts by weight, calcium carbonate 1-10 parts by weight, pantothenic acid 0.1-0.5 parts by weight, maltitol 5-10 parts by weight, Effervescent tablet precursor by mixing 1-5 parts by weight of fragrance, 0.5-1 parts by weight of modified starch, 0.1-1 parts by weight of dye, 0.1-0.5 parts by weight of stevia, 0.1-0.5 parts by weight of acesulfame potassium, and 0.1-0.5 parts by weight of sucralose can be manufactured.

In the case of the present invention, as described above, by using a mixture of sprout oat active ingredient extract powder and zeolite to which sprout oat active ingredient extract is adsorbed, the initial concentration of the active ingredient can be improved and the concentration of the active ingredient can be maintained for a certain period of time. there is. At this time, the sprout oat active ingredient extract powder serves to form an initial concentration of the active ingredient, and the zeolite to which the sprout oat active ingredient extract is adsorbed may serve to maintain the concentration of the active ingredient.

The vitamin D is added for skin improvement, anti-aging, calcium supplementation, etc., and may contain 0.1 to 0.5 parts by weight in the effervescent tablet. When the vitamin D is contained in less than 0.1 parts by weight, it is difficult to expect the effect of vitamin D, and when it exceeds 0.5 parts by weight, there is a possibility of causing side effects such as poor eating and diarrhea.

The foaming agent is decomposed by generating gas when the effervescent tablet comes in contact with water, and thus facilitates mixing of active ingredients and other ingredients. As described above, sodium bicarbonate can be coated with sugar and used. When the sodium bicarbonate comes into contact with water, it generates carbon dioxide, and as this carbon dioxide is discharged upward from the water, it can create a flow for mixing the water. That is, when the effervescent tablet is put into water, the carbon dioxide is generated and water can be mixed, so that the water can be mixed with the active ingredient and other ingredients without using other mixing means. At this time, when less than 20 parts by weight of the sugar-coated foaming agent is used, it is difficult to mix as described above. there is.

The second potassium phosphate is included in the effervescent tablet and acts as a dispersant when the effervescent tablet is dissolved in water. Through this, the active ingredient contained in the effervescent tablet and the zeolite to which the active ingredient is adsorbed can be easily dispersed in the water, and the ingestion can be facilitated by dispersing without sinking into the water even after a certain time has elapsed. . In this case, the dispersant may be included in 0.1 to 2 parts by weight of the effervescent tablet. If the dispersant is included in an amount of less than 0.1 parts by weight, the dispersing effect due to the dispersant may be lowered and zeolite or active ingredients may be precipitated. can give

The nicotinic acid amide is a type of vitamin B and has an effect of improving skin diseases or gastrointestinal disorders. The nicotinic acid amide may contain 0.1 to 0.5 parts by weight.

The pantothenic acid refers to vitamin B5, and may be included in the effervescent tablet to give effects such as growth and strength enhancement, nervous system strengthening, and the like. The pantothenic acid may be included in 0.1 to 0.5 parts by weight of the effervescent tablet.

The zinc is a mineral involved in amino acid metabolism, and is a mineral involved in male hormone muscle production and skin beauty. The effervescent tablet of the present invention may contain 0.1 to 0.5 parts by weight of the zinc.

The calcium carbonate is added to supplement calcium and to improve gastrointestinal disorders, and is a component used as an extender for the effervescent tablet. The effervescent tablet may include 1 to 10 parts by weight of the calcium carbonate. When the calcium carbonate is included in less than 1 part by weight, it is difficult to expect the effect of the calcium carbonate, and the size of the effervescent tablet may be small, so handling may be difficult, and if it exceeds 10 parts by weight, precipitation may occur or the The size of the effervescent tablet may be excessively large, making it difficult to store.

The modified starch is used as an extender and a binder of the effervescent tablet, and 0.5 to 1 part by weight may be included in the effervescent tablet.

The fragrance is a substance that emits a fragrance for ease of ingestion when the effervescent tablet is ingested, and various fragrances may be combined to facilitate intake. As an example, when the lemon flavor is added in combination with the citric acid, when the effervescent tablet is dissolved, a liquid having a lemon flavor and taste can be prepared. You can make it smell. The fragrance may be included in 1 to 5 parts by weight of the effervescent tablet. When the fragrance is contained in an amount of less than 1 part by weight, it is difficult to expect an improvement effect by the fragrance, and when the fragrance exceeds 5 parts by weight, ingestion may be rather difficult due to the strong fragrance.

The pigment may be combined with the fragrance so that the water in which the effervescent tablet is dissolved has a certain color, and may have a color combined with the fragrance generated by the fragrance. As an example, when lemon flavor is used as the perfume, a yellow pigment may be used, and when a strawberry flavor perfume is used, a red pigment may be used to have an appropriate color. The dye may be included in the effervescent tablet 0.1 to 1 part by weight.

The citric acid powder is included in the effervescent tablet, dissolved in water, and then used as a sweetener as well as adding sour taste. 20-30 parts by weight of such citric acid may be included in the effervescent tablet, and when it is included in less than 20 parts by weight, it is difficult to see the effect due to the addition of citric acid, and when it exceeds 30 parts by weight, it is not easy to ingest due to too strong acidity it may not be

The maltitol is one of the sugar alcohols and may be used as a sweetener. The effervescent tablet may contain 5 to 10 parts by weight, and when it is included in less than 5 parts by weight, the sweetening effect of the maltitol may be reduced, and when it exceeds 10 parts by weight, side effects such as diarrhea may appear.

The stevia is included in the effervescent tablet and used as a sweetener, and may serve to enhance the sweetness of sultan and at the same time supplement a little bitterness to add a fruity taste due to the flavoring. The stevia may be included in 0.1 to 0.5 parts by weight of the effervescent tablet.

The acesulfame potassium is included in the effervescent tablet and used as a sweetener, and may reinforce the sweetness of sultan. In particular, the acesulfame kamrium can be used as a sweetener with a quick sense of sweetness. The acesulfame potassium may be included in 0.1 to 0.5 parts by weight of the effervescent tablet.

The sucralose is included in the effervescent tablet and used as a sweetener, and may reinforce the sweetness of sultan. It has stability against heat and has a high sweetening effect, so it is used in many foods. The effervescent tablet of the present invention may contain 0.1 to 0.5 parts by weight of the sucralose.

The effervescent tablet precursor mixed in the above ratio can be produced by using a tableting machine.

The present invention also relates to an effervescent tablet prepared by the method.

Hereinafter, preferred embodiments of the present invention will be described so that those of ordinary skill in the art can easily implement them with reference to the accompanying drawings. In addition, in the description of the present invention, if it is determined that a detailed description of a related known function or a known configuration may unnecessarily obscure the gist of the present invention, the detailed description thereof will be omitted. In addition, certain features presented in the drawings are enlarged, reduced, or simplified for ease of explanation, and the drawings and components thereof are not necessarily drawn to scale. However, those skilled in the art will readily appreciate these details.

Example 1

10 kg of outer oats from Goheung, Jeollanam-do were immersed in water for 60 minutes, and then water and seeds were separated. The separated seeds were immersed in half to be submerged and left at a temperature of 20° C. for 24 hours to germinate.

The germinated oat seeds were arranged so as not to overlap on a wide plate, and a porous plate having a diameter of 3 mm was covered on the top. After that, while supplying water every 12 hours, the sprouted oats were cultivated and harvested to a length of 15 cm.

The collected sprouted oats were washed, and then dried at a temperature of 70° C. so that the moisture content was less than 5% by weight, and the inside of the dryer was replaced with nitrogen and dried.

The dried sprouted oats were put into the expander, the inside was replaced with nitrogen, and then the expansion was performed at 230° C. and 1.5 Mpa. The expanded sprouted oats were put into a ball mill and pulverized into powder.

After mixing with 100 g of the pulverized oat sprout powder in a ratio of 180 g of ethanol, a microwave of 20 kHz was supplied at an intensity of 700 W for 10 minutes to promote decomposition of cellulose. Thereafter, the solids were separated through filtration under reduced pressure, and then vacuum concentration and freeze-drying were performed to prepare an active ingredient extract of sprout oats.

Example 2

The same procedure was performed except that the swelling process was not performed in Example 1.

Example 3

The same procedure was performed except that in Example 1, the extraction process using ultrasound was not performed.

Example 4

In Example 1, the same procedure was performed except that air was used instead of nitrogen in the drying process and the expanded lump tablet.

Example 5

500 g of water was mixed with 100 g of the active ingredient extract prepared in Example 1, and 100 g of zeolite having an average diameter of 50 nm was mixed to prepare a zeolite to which the active ingredient extract was adsorbed.

A foaming agent coated with sugar was prepared by mixing 80 parts by weight of sodium bicarbonate and 20 parts by weight of sugar using a fluidized bed granulation dryer.

15 parts by weight of the active ingredient extract prepared in Example 1, 23 parts by weight of the foaming agent coated with sugar, 8 parts by weight of the zeolite to which the active ingredient extract was adsorbed, 1 part by weight of potassium dibasic, 24 parts by weight of citric acid powder parts, nicotinic acid amide 0.2 parts by weight, zinc 0.3 parts by weight, calcium carbonate 5 parts by weight, pantothenic acid 0.2 parts by weight, maltitol 6 parts by weight, fragrance 3 parts by weight, modified starch 0.8 parts by weight, dye 0.2 parts by weight, stevia 0.3 parts by weight, An effervescent tablet precursor was prepared by mixing 0.3 parts by weight of acesulfame potassium and 0.2 parts by weight of sucralose, and then, an effervescent tablet was prepared using a tableting machine.

Example 6

In Example 5, 15 parts by weight of the active ingredient extract of sprout oat extract and 8 parts by weight of the zeolite to which the active ingredient extract of sprout oat was adsorbed were used in the same manner except that 23 parts by weight of the active ingredient extract of sprout oat was used.

Example 7

In Example 5, 15 parts by weight of the oat sprout active ingredient extract and 8 parts by weight of the zeolite to which the sprout oat active ingredient extract was adsorbed were used in the same manner except that 23 parts by weight of the zeolite to which the sprout oat active ingredient extract was adsorbed was used.

Experimental Example 1

An experiment was conducted to confirm the anti-obesity effect of the active ingredient extract of sprout oat.

The effect of inhibiting proliferation of 3T3-L1 adipocytes was tested as follows.

First, the 3T3-L1 progenitor adipocyte cell line was purchased from the American Type Culture Collection (ATCC, USA).

Preadipocyte 3T3-L1 cells were treated with 5% CO2 and 5% CO2 in Dulbecco's Modified Eagle Medium (DMEM, Hyclone) medium containing 100 Units/mL penicillin, 100 μg/mL streptomycin, and 10% newbone calf serum (FCS, Hyclone). Subculture in a cell incubator at 37 ° C. and use for the experiment.

The effect of inhibiting proliferation of 3T3-L1 adipocytes was tested as follows.

First, 3T3-L1 cells were aliquoted at 1x10 ³ per well in a 96 well plate and cultured for about 24 hours. After starvation with a serum-free medium for 24 hours, the extracts of Examples 1-5 were treated at various concentrations for 8 days while exchanging the medium at 2-day intervals.

Thereafter, treatment is performed so that the final concentration of the MTT reagent is 0.1 mg/ml, and the reaction is performed at 37° C. for 4 hours. After removing the medium, the formazan crystal product is dissolved by adding 200 μl of dimethyl sulfoxide (DMSO). Absorbance was measured at 570 nm using a microplate reader.

Table 1 below shows the effect of inhibiting proliferation of the 3T3-L1 adipocytes.

0 μg/ml 3 μg/ml 10 μg/ml 20 μg/ml Example 1 100% 61% 57% 49% Example 2 100% 74% 65% 61% Example 3 100% 75% 74% 63% Example 4 100% 68% 61% 57%

As shown in Table 1, Example 1 of the present invention was found to have a high inhibitory effect on the proliferation of adipocytes. However, Example 2 without the swelling process and Example 3 without ultrasonic extraction were found to have a low effect compared to the present invention, and Example 4 in which an inert gas was not used in the drying process and the swelling process It was also found to be ineffective. That is, in the case of Example 1 of the present invention, the extraction efficiency was found to be higher than that of Examples 2 and 3.

Test Example 2

Experiments were performed using the effervescent tablets of Examples 5 to 7, which were prepared using the active ingredient extract of sprout oat of Example 1. Twenty selected experiment participants were instructed to dissolve one effervescent tablet in 250 ml of water once a day at 12 hour intervals. In addition to Examples 5 to 7, effervescent tablets were prepared in which no sprout oat active ingredient extract powder was added, and then added as Comparative Example 1.

Changes in body weight (G, unit g) and waist circumference (W, unit mm) were measured before meals at 8 am every 5 days, and are shown in Table 2 below.

0 5 days 10 days 15th 20 days 25 days 30 days G W G W G W G W G W G W G W Example 5 0 0 110 6 220 10 540 22 760 37 890 44 980 51 Example 6 0 0 120 4 190 9 380 12 550 17 700 22 850 37 Example 7 0 0 110 3 150 8 310 10 500 16 660 21 760 30 Comparative Example 1 0 0 70 One 110 6 190 9 240 10 270 12 340 13

As shown in Table 2, in the case of Example 5 of the present invention, it was found that the decrease in waist circumference and body zoom was remarkable as time hardened. In the case of Example 6 without using zeolite, the effect was found to be lower than that of Example 5, and in the case of Example 7 using only the sprout powder active ingredient extract adsorbed on the zeolite, the release rate was slow and the effect was further reduced. appeared to be In the case of Comparative Example 1, which did not use the active ingredient extract of sprout oat, some weight and waist circumference decreased due to regular eating habits, but the effect was lower than that of the Example of the present invention.

In the above, preferred embodiments of the present invention have been illustrated and described, but the present invention is not limited to the specific embodiments described above, and it is common in the technical field to which the present invention pertains without departing from the gist of the present invention as claimed in the claims. Various modifications are possible by those having the knowledge of, of course, and these modifications should not be individually understood from the technical spirit or perspective of the present invention.

Claims (7)

In the manufacturing method of the effervescent tablet containing the sprout oat extract,
The manufacturing method of the effervescent tablet,
immersing the pre-treated sprouted oats in lower alcohol having 1 to 5 carbon atoms to elute the active ingredient;
recovering the active ingredient and then mixing it with vitamin D, a foaming agent, a dispersing agent and an extender to prepare an effervescent tablet precursor; and
tableting the effervescent tablet precursor using a tablet press;
includes,
The pre-treated sprout oats,
Soaking oat seeds in water for 10 to 120 minutes, then separating the seeds from the water;
After immersing half of the separated oat seeds submerged, sprouting for 10 to 30 hours at a temperature of 10 to 30 ℃;
arranging the sprouted oats to form one layer, and then placing a porous plate with a diameter of 2-5 mm on top of the oat layer;
supplying water to the oats in units of 10 to 20 hours;
Harvesting when the sprouted oats grown on the upper portion of the porous plate reach 10 to 20 cm;
charging the harvested sprouted oats into a dryer, then replacing the inside with an inert gas and drying at a temperature of 60 to 80° C. with a moisture content of less than 5% by weight;
charging the dried sprouted oats into the expander, then substituting the inside with an inert gas and swelling using a temperature of 200 to 250° C. and a pressure of 1 to 3 Mpa; and
It is prepared by a method comprising the step of powdering the swollen sprout oats,
The step of eluting the active ingredient,
immersing the sprouted oat powder by supplying 150 to 200 parts by weight of a lower alcohol having 1 to 5 carbon atoms compared to 100 parts by weight of the powdered sprout oats to the powdered sprout oats;
eluting the active ingredient by supplying ultrasonic waves having a frequency of 10 to 70 kHz to the immersed sprout oat powder at an intensity of 500 to 1000 W for 5 to 20 minutes;
Separating the liquid component by filtration under reduced pressure after the elution is completed; and
Concentrating the liquid component in a vacuum and freeze-drying to prepare an active ingredient extract of sprout oats;
includes,
The method for preparing the effervescent tablet precursor,
Mixing and dissolving 400 to 600 parts by weight of water in 100 parts by weight of the sprout oat active ingredient extract;
adding 100 parts by weight of zeolite having an average diameter of 30 to 100 nm to the active ingredient extract of sprout oat dissolved in water to adsorb the active ingredient extract of sprout oat into the pores of the zeolite;
Preparing a foaming agent coated with sugar by mixing 80 to 90 parts by weight of sodium bicarbonate and 10 to 20 parts by weight of sugar using a fluidized bed granulation dryer; and
10-20 parts by weight of active ingredient extract powder, vitamin D, 0.1-0.5 parts by weight, 20-30 parts by weight of a sugar-coated foaming agent, 5-10 parts by weight of zeolite adsorbed with sprout oat active ingredient extract, dibasic phosphoric acid 0.1 to 2 parts by weight of potassium, 20 to 30 parts by weight of citric acid powder, 0.1 to 0.5 parts by weight of nicotinic acid amide, 0.1 to 0.5 parts by weight of zinc, 1 to 10 parts by weight of calcium carbonate, 0.1 to 0.5 parts by weight of pantothenic acid, 5 to 10 parts by weight of maltitol Parts, fragrance, 1-5 parts by weight, modified starch 0.5-1 parts by weight, dye 0.1-1 parts by weight, stevia 0.1-0.5 parts by weight, acesulfame potassium 0.1-0.5 parts by weight, and sucralose 0.1-0.5 parts by weight are mixed and foamed preparing a positive precursor;
A method for producing effervescent tablets comprising a sprout oat extract having an obesity inhibitory effect, comprising:

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