KR102368174B1 - 유동 분배기 - Google Patents

유동 분배기 Download PDF

Info

Publication number
KR102368174B1
KR102368174B1 KR1020197032202A KR20197032202A KR102368174B1 KR 102368174 B1 KR102368174 B1 KR 102368174B1 KR 1020197032202 A KR1020197032202 A KR 1020197032202A KR 20197032202 A KR20197032202 A KR 20197032202A KR 102368174 B1 KR102368174 B1 KR 102368174B1
Authority
KR
South Korea
Prior art keywords
channel
fluid
distributor
common channel
substructure
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
KR1020197032202A
Other languages
English (en)
Korean (ko)
Other versions
KR20200021046A (ko
Inventor
게르트 데스멧
샌더 예스페르스
샌더 데리더
Original Assignee
파마플루이딕스 엔브이
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 파마플루이딕스 엔브이 filed Critical 파마플루이딕스 엔브이
Publication of KR20200021046A publication Critical patent/KR20200021046A/ko
Application granted granted Critical
Publication of KR102368174B1 publication Critical patent/KR102368174B1/ko
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0093—Microreactors, e.g. miniaturised or microfabricated reactors
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
    • B01F25/40—Static mixers
    • B01F25/41—Mixers of the fractal type
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/30—Micromixers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/30—Micromixers
    • B01F33/301—Micromixers using specific means for arranging the streams to be mixed, e.g. channel geometries or dispositions
    • B01F33/3012—Interdigital streams, e.g. lamellae
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502707—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the manufacture of the container or its components
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502746—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means for controlling flow resistance, e.g. flow controllers, baffles or throttle valves
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/60—Construction of the column
    • G01N30/6004—Construction of the column end pieces
    • G01N30/6017—Fluid distributors
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F2101/00—Mixing characterised by the nature of the mixed materials or by the application field
    • B01F2101/2204—Mixing chemical components in generals in order to improve chemical treatment or reactions, independently from the specific application
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F2101/00—Mixing characterised by the nature of the mixed materials or by the application field
    • B01F2101/23—Mixing of laboratory samples e.g. in preparation of analysing or testing properties of materials
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00889—Mixing
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00891—Feeding or evacuation
    • B01J2219/00894—More than two inlets
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00891—Feeding or evacuation
    • B01J2219/00896—Changing inlet or outlet cross-section, e.g. pressure-drop compensation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00891—Feeding or evacuation
    • B01J2219/00898—Macro-to-Micro (M2M)
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0816—Cards, e.g. flat sample carriers usually with flow in two horizontal directions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0864—Configuration of multiple channels and/or chambers in a single devices comprising only one inlet and multiple receiving wells, e.g. for separation, splitting
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0867—Multiple inlets and one sample wells, e.g. mixing, dilution
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/08—Regulating or influencing the flow resistance
    • B01L2400/084—Passive control of flow resistance
    • B01L2400/086—Passive control of flow resistance using baffles or other fixed flow obstructions

Landscapes

  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Hematology (AREA)
  • Clinical Laboratory Science (AREA)
  • Biochemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Organic Chemistry (AREA)
  • Feeding, Discharge, Calcimining, Fusing, And Gas-Generation Devices (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Peptides Or Proteins (AREA)
KR1020197032202A 2017-03-31 2018-03-30 유동 분배기 Expired - Fee Related KR102368174B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP17164445.3 2017-03-31
EP17164445.3A EP3381531A1 (en) 2017-03-31 2017-03-31 Flow distributor
PCT/EP2018/058300 WO2018178337A1 (en) 2017-03-31 2018-03-30 Flow distributor

Publications (2)

Publication Number Publication Date
KR20200021046A KR20200021046A (ko) 2020-02-27
KR102368174B1 true KR102368174B1 (ko) 2022-02-28

Family

ID=58536722

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020197032202A Expired - Fee Related KR102368174B1 (ko) 2017-03-31 2018-03-30 유동 분배기

Country Status (10)

Country Link
US (1) US11207682B2 (enExample)
EP (2) EP3381531A1 (enExample)
JP (1) JP7126512B2 (enExample)
KR (1) KR102368174B1 (enExample)
CN (1) CN110913967B (enExample)
AU (1) AU2018246354A1 (enExample)
CA (1) CA3058034A1 (enExample)
DK (1) DK3600594T3 (enExample)
SG (1) SG11201908991VA (enExample)
WO (1) WO2018178337A1 (enExample)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE1028976B1 (nl) 2020-12-30 2022-08-01 Pharmafluidics N V Pilaarstructuren

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20160279637A1 (en) 2013-11-22 2016-09-29 The General Hospital Corporation Microfluidic methods and systems for isolating particle clusters

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3613683A1 (de) * 1986-04-23 1987-11-05 Liebisch Geb Vorrichtung fuer die gesteuerte verteilung stroemungsfaehiger medien
EP0264581A1 (de) * 1986-10-02 1988-04-27 GebràœDer Sulzer Aktiengesellschaft Vorrichtung zur Flüssigkeitsverteilung für Stoff- und Wärmeaustauschkolonnen
AU617869B2 (en) * 1988-11-03 1991-12-05 Koch (Cyprus) Limited Liquid distributor assembly for packed tower
ATA166091A (de) * 1991-08-23 1996-02-15 Faigle Heinz Kg Füllkörper
TW293783B (enExample) * 1995-06-16 1996-12-21 Ciba Geigy Ag
AU2001261462A1 (en) * 2000-05-12 2001-11-26 University Of Cincinnati Structurally programmable microfluidic systems
GB2366529A (en) * 2000-09-11 2002-03-13 Univ Sheffield Fluidic control valve for an assembly containing a plurality of microreactors
ATE534457T1 (de) * 2001-05-17 2011-12-15 Amalgamated Res Inc Fraktalstruktur zum mischen von mindestens zwei fluiden
DE10141526A1 (de) * 2001-08-24 2003-04-17 Zae Bayern Bayerisches Zentrum Fuer Angewandte Energieforschung Ev Kleinstflüssigkeitsmengenverteiler
AU2003213071A1 (en) * 2002-02-13 2003-09-04 Nanostream, Inc. Microfluidic separation column devices and fabrication methods
US6863121B2 (en) * 2002-04-16 2005-03-08 Shell Oil Company Flow distributor for an alkylation reactor or heat exchanger
JP5376602B2 (ja) * 2008-03-31 2013-12-25 国立大学法人京都大学 流体分配装置、マイクロプラント及び流路閉塞検知方法
CN100500296C (zh) * 2008-04-28 2009-06-17 上海应用技术学院 流量可调的点动式计量分配器
CN201259475Y (zh) * 2008-08-06 2009-06-17 四川美生科技有限公司 流体定量分配器
EP2172260A1 (en) * 2008-09-29 2010-04-07 Corning Incorporated Multiple flow path microfluidic devices
US8802019B2 (en) * 2010-12-21 2014-08-12 Basf Se Reactor for carrying out an autothermal gas-phase dehydrogenation
CN104624148B (zh) * 2014-12-19 2016-06-08 天津大学 带收集槽式液体分布器
CN204709866U (zh) * 2015-06-18 2015-10-21 江苏汉邦科技有限公司 一种新型流动相分配器

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20160279637A1 (en) 2013-11-22 2016-09-29 The General Hospital Corporation Microfluidic methods and systems for isolating particle clusters

Also Published As

Publication number Publication date
DK3600594T3 (da) 2021-08-23
SG11201908991VA (en) 2019-10-30
US20200215543A1 (en) 2020-07-09
US11207682B2 (en) 2021-12-28
CN110913967B (zh) 2022-04-22
KR20200021046A (ko) 2020-02-27
WO2018178337A1 (en) 2018-10-04
EP3600594A1 (en) 2020-02-05
EP3600594B1 (en) 2021-06-02
CA3058034A1 (en) 2018-10-04
JP2020515392A (ja) 2020-05-28
AU2018246354A1 (en) 2019-11-14
JP7126512B2 (ja) 2022-08-26
CN110913967A (zh) 2020-03-24
EP3381531A1 (en) 2018-10-03

Similar Documents

Publication Publication Date Title
Shao et al. CFD simulations of the effect of inlet conditions on Taylor flow formation
AU2013219171B2 (en) Flow sensor with multi-position laminar flow element having integrated bypass channels
CN104436757B (zh) 压力耦合式层析柱流体分配器
US8652420B2 (en) Device for the distribution of sample and carrier liquid across a micro-fabricated separation channel
US8318024B2 (en) System and method for distribution of fluid a multistage column
Arbat et al. An experimental and analytical study to analyze hydraulic behavior of nozzle-type underdrains in porous media filters
Jespers et al. A microfluidic distributor combining minimal volume, minimal dispersion and minimal sensitivity to clogging
Berger Instrument modifications that produced reduced plate heights< 2 with sub-2 μm particles and 95% of theoretical efficiency at k= 2 in supercritical fluid chromatography
JP7126512B2 (ja) 流れ分配器
Davydova et al. Optimization and evaluation of radially interconnected versus bifurcating flow distributors using computational fluid dynamics modelling
Gzil et al. Computational fluid dynamics simulations yielding guidelines for the ideal internal structure of monolithic liquid chromatography columns
Vangelooven et al. Computer aided design optimisation of microfluidic flow distributors
US20210187504A1 (en) Microfluidic device
Vangelooven et al. Theoretical optimisation of the side-wall of micropillar array columns using computational fluid dynamics
Valenz et al. Gas and liquid axial mixing in the column packed with Mellapak 250Y, Pall rings 25, and Intalox saddles 25 under flow conditions prevailing in distillation columns
Zhang et al. Mesoscopic simulation of multi-scheme particle separation in deterministic lateral displacement devices using two-piece hybrid pillars
Ma et al. Numerical simulation and experimental analysis of the influence of asymmetric pressure conditions on the splitting of a Gas-liquid Two-phase flow at a T-junction
US12209895B2 (en) Inlet dividers having a plurality of analyzing and production apertures for analyzing multiphase production fluid as well as systems incorporating the same
Waltrich et al. Performance of vertical transient two-phase flow models applied to liquid loading in gas wells
Tekavčič et al. The concept of liquid inlet model and its effect on the flooding wave frequency in vertical air-water churn flow
Maheshwari et al. Marginal Field Development–Challenges in Fiscal Oil Allocation
Shen et al. A versatile microfluidic intermediate delivery reservoir for isolating fluid dynamics in serially interconnected microfluidic networks
Provenzano et al. Discussion of “Comparative Analysis of Hydraulic Calculation Methods in Design of Microirrigation Laterals” by Gürol Yildirim and Necati Ağiralioğlu
JP2005118779A (ja) 流体の吐出路構造
JP2011180992A (ja) 流体分配装置及びマイクロプラント

Legal Events

Date Code Title Description
PA0105 International application

St.27 status event code: A-0-1-A10-A15-nap-PA0105

P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

R18-X000 Changes to party contact information recorded

St.27 status event code: A-3-3-R10-R18-oth-X000

PG1501 Laying open of application

St.27 status event code: A-1-1-Q10-Q12-nap-PG1501

A201 Request for examination
A302 Request for accelerated examination
E13-X000 Pre-grant limitation requested

St.27 status event code: A-2-3-E10-E13-lim-X000

P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

PA0201 Request for examination

St.27 status event code: A-1-2-D10-D11-exm-PA0201

PA0302 Request for accelerated examination

St.27 status event code: A-1-2-D10-D17-exm-PA0302

St.27 status event code: A-1-2-D10-D16-exm-PA0302

R17-X000 Change to representative recorded

St.27 status event code: A-3-3-R10-R17-oth-X000

E902 Notification of reason for refusal
PE0902 Notice of grounds for rejection

St.27 status event code: A-1-2-D10-D21-exm-PE0902

T11-X000 Administrative time limit extension requested

St.27 status event code: U-3-3-T10-T11-oth-X000

P11-X000 Amendment of application requested

St.27 status event code: A-2-2-P10-P11-nap-X000

P13-X000 Application amended

St.27 status event code: A-2-2-P10-P13-nap-X000

E701 Decision to grant or registration of patent right
PE0701 Decision of registration

St.27 status event code: A-1-2-D10-D22-exm-PE0701

P22-X000 Classification modified

St.27 status event code: A-2-2-P10-P22-nap-X000

GRNT Written decision to grant
PR0701 Registration of establishment

St.27 status event code: A-2-4-F10-F11-exm-PR0701

PR1002 Payment of registration fee

St.27 status event code: A-2-2-U10-U12-oth-PR1002

Fee payment year number: 1

PG1601 Publication of registration

St.27 status event code: A-4-4-Q10-Q13-nap-PG1601

PC1903 Unpaid annual fee

St.27 status event code: A-4-4-U10-U13-oth-PC1903

Not in force date: 20250224

Payment event data comment text: Termination Category : DEFAULT_OF_REGISTRATION_FEE

H13 Ip right lapsed

Free format text: ST27 STATUS EVENT CODE: N-4-6-H10-H13-OTH-PC1903 (AS PROVIDED BY THE NATIONAL OFFICE); TERMINATION CATEGORY : DEFAULT_OF_REGISTRATION_FEE

Effective date: 20250224

PC1903 Unpaid annual fee

St.27 status event code: N-4-6-H10-H13-oth-PC1903

Ip right cessation event data comment text: Termination Category : DEFAULT_OF_REGISTRATION_FEE

Not in force date: 20250224