CA3058034A1 - Flow distributor - Google Patents

Flow distributor Download PDF

Info

Publication number
CA3058034A1
CA3058034A1 CA3058034A CA3058034A CA3058034A1 CA 3058034 A1 CA3058034 A1 CA 3058034A1 CA 3058034 A CA3058034 A CA 3058034A CA 3058034 A CA3058034 A CA 3058034A CA 3058034 A1 CA3058034 A1 CA 3058034A1
Authority
CA
Canada
Prior art keywords
distributor
common channel
fluid
channel
pillar
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CA3058034A
Other languages
English (en)
French (fr)
Inventor
Gert Desmet
Sander JESPERS
Sander DERIDDER
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pharmafluidics NV
Original Assignee
Pharmafluidics NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmafluidics NV filed Critical Pharmafluidics NV
Publication of CA3058034A1 publication Critical patent/CA3058034A1/en
Pending legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0093—Microreactors, e.g. miniaturised or microfabricated reactors
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
    • B01F25/40—Static mixers
    • B01F25/41—Mixers of the fractal type
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/30—Micromixers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/30—Micromixers
    • B01F33/301—Micromixers using specific means for arranging the streams to be mixed, e.g. channel geometries or dispositions
    • B01F33/3012—Interdigital streams, e.g. lamellae
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502707—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the manufacture of the container or its components
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502746—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means for controlling flow resistance, e.g. flow controllers, baffles or throttle valves
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/60—Construction of the column
    • G01N30/6004—Construction of the column end pieces
    • G01N30/6017—Fluid distributors
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F2101/00—Mixing characterised by the nature of the mixed materials or by the application field
    • B01F2101/2204—Mixing chemical components in generals in order to improve chemical treatment or reactions, independently from the specific application
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F2101/00—Mixing characterised by the nature of the mixed materials or by the application field
    • B01F2101/23—Mixing of laboratory samples e.g. in preparation of analysing or testing properties of materials
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00889—Mixing
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00891—Feeding or evacuation
    • B01J2219/00894—More than two inlets
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00891—Feeding or evacuation
    • B01J2219/00896—Changing inlet or outlet cross-section, e.g. pressure-drop compensation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00891—Feeding or evacuation
    • B01J2219/00898—Macro-to-Micro (M2M)
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0816—Cards, e.g. flat sample carriers usually with flow in two horizontal directions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0864—Configuration of multiple channels and/or chambers in a single devices comprising only one inlet and multiple receiving wells, e.g. for separation, splitting
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0867—Multiple inlets and one sample wells, e.g. mixing, dilution
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/08—Regulating or influencing the flow resistance
    • B01L2400/084—Passive control of flow resistance
    • B01L2400/086—Passive control of flow resistance using baffles or other fixed flow obstructions

Landscapes

  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Hematology (AREA)
  • Clinical Laboratory Science (AREA)
  • Biochemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Organic Chemistry (AREA)
  • Feeding, Discharge, Calcimining, Fusing, And Gas-Generation Devices (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Peptides Or Proteins (AREA)
CA3058034A 2017-03-31 2018-03-30 Flow distributor Pending CA3058034A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP17164445.3 2017-03-31
EP17164445.3A EP3381531A1 (en) 2017-03-31 2017-03-31 Flow distributor
PCT/EP2018/058300 WO2018178337A1 (en) 2017-03-31 2018-03-30 Flow distributor

Publications (1)

Publication Number Publication Date
CA3058034A1 true CA3058034A1 (en) 2018-10-04

Family

ID=58536722

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3058034A Pending CA3058034A1 (en) 2017-03-31 2018-03-30 Flow distributor

Country Status (10)

Country Link
US (1) US11207682B2 (enExample)
EP (2) EP3381531A1 (enExample)
JP (1) JP7126512B2 (enExample)
KR (1) KR102368174B1 (enExample)
CN (1) CN110913967B (enExample)
AU (1) AU2018246354A1 (enExample)
CA (1) CA3058034A1 (enExample)
DK (1) DK3600594T3 (enExample)
SG (1) SG11201908991VA (enExample)
WO (1) WO2018178337A1 (enExample)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE1028976B1 (nl) 2020-12-30 2022-08-01 Pharmafluidics N V Pilaarstructuren

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3613683A1 (de) * 1986-04-23 1987-11-05 Liebisch Geb Vorrichtung fuer die gesteuerte verteilung stroemungsfaehiger medien
EP0264581A1 (de) * 1986-10-02 1988-04-27 GebràœDer Sulzer Aktiengesellschaft Vorrichtung zur Flüssigkeitsverteilung für Stoff- und Wärmeaustauschkolonnen
AU617869B2 (en) * 1988-11-03 1991-12-05 Koch (Cyprus) Limited Liquid distributor assembly for packed tower
ATA166091A (de) * 1991-08-23 1996-02-15 Faigle Heinz Kg Füllkörper
TW293783B (enExample) * 1995-06-16 1996-12-21 Ciba Geigy Ag
AU2001261462A1 (en) * 2000-05-12 2001-11-26 University Of Cincinnati Structurally programmable microfluidic systems
GB2366529A (en) * 2000-09-11 2002-03-13 Univ Sheffield Fluidic control valve for an assembly containing a plurality of microreactors
ATE534457T1 (de) * 2001-05-17 2011-12-15 Amalgamated Res Inc Fraktalstruktur zum mischen von mindestens zwei fluiden
DE10141526A1 (de) * 2001-08-24 2003-04-17 Zae Bayern Bayerisches Zentrum Fuer Angewandte Energieforschung Ev Kleinstflüssigkeitsmengenverteiler
AU2003213071A1 (en) * 2002-02-13 2003-09-04 Nanostream, Inc. Microfluidic separation column devices and fabrication methods
US6863121B2 (en) * 2002-04-16 2005-03-08 Shell Oil Company Flow distributor for an alkylation reactor or heat exchanger
JP5376602B2 (ja) * 2008-03-31 2013-12-25 国立大学法人京都大学 流体分配装置、マイクロプラント及び流路閉塞検知方法
CN100500296C (zh) * 2008-04-28 2009-06-17 上海应用技术学院 流量可调的点动式计量分配器
CN201259475Y (zh) * 2008-08-06 2009-06-17 四川美生科技有限公司 流体定量分配器
EP2172260A1 (en) * 2008-09-29 2010-04-07 Corning Incorporated Multiple flow path microfluidic devices
US8802019B2 (en) * 2010-12-21 2014-08-12 Basf Se Reactor for carrying out an autothermal gas-phase dehydrogenation
CA2930430A1 (en) * 2013-11-22 2015-05-28 The General Hospital Corporation Microfluidic methods and systems for isolating particle clusters
CN104624148B (zh) * 2014-12-19 2016-06-08 天津大学 带收集槽式液体分布器
CN204709866U (zh) * 2015-06-18 2015-10-21 江苏汉邦科技有限公司 一种新型流动相分配器

Also Published As

Publication number Publication date
DK3600594T3 (da) 2021-08-23
SG11201908991VA (en) 2019-10-30
US20200215543A1 (en) 2020-07-09
KR102368174B1 (ko) 2022-02-28
US11207682B2 (en) 2021-12-28
CN110913967B (zh) 2022-04-22
KR20200021046A (ko) 2020-02-27
WO2018178337A1 (en) 2018-10-04
EP3600594A1 (en) 2020-02-05
EP3600594B1 (en) 2021-06-02
JP2020515392A (ja) 2020-05-28
AU2018246354A1 (en) 2019-11-14
JP7126512B2 (ja) 2022-08-26
CN110913967A (zh) 2020-03-24
EP3381531A1 (en) 2018-10-03

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