JP2020515392A - 流れ分配器 - Google Patents
流れ分配器 Download PDFInfo
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- JP2020515392A JP2020515392A JP2019553319A JP2019553319A JP2020515392A JP 2020515392 A JP2020515392 A JP 2020515392A JP 2019553319 A JP2019553319 A JP 2019553319A JP 2019553319 A JP2019553319 A JP 2019553319A JP 2020515392 A JP2020515392 A JP 2020515392A
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502746—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means for controlling flow resistance, e.g. flow controllers, baffles
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
- B01F25/40—Static mixers
- B01F25/41—Mixers of the fractal type
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F33/00—Other mixers; Mixing plants; Combinations of mixers
- B01F33/30—Micromixers
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F33/00—Other mixers; Mixing plants; Combinations of mixers
- B01F33/30—Micromixers
- B01F33/301—Micromixers using specific means for arranging the streams to be mixed, e.g. channel geometries or dispositions
- B01F33/3012—Interdigital streams, e.g. lamellae
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J19/0093—Microreactors, e.g. miniaturised or microfabricated reactors
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502707—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the manufacture of the container or its components
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/60—Construction of the column
- G01N30/6004—Construction of the column end pieces
- G01N30/6017—Fluid distributors
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F2101/00—Mixing characterised by the nature of the mixed materials or by the application field
- B01F2101/2204—Mixing chemical components in generals in order to improve chemical treatment or reactions, independently from the specific application
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
- B01F2101/00—Mixing characterised by the nature of the mixed materials or by the application field
- B01F2101/23—Mixing of laboratory samples e.g. in preparation of analysing or testing properties of materials
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00781—Aspects relating to microreactors
- B01J2219/00889—Mixing
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00781—Aspects relating to microreactors
- B01J2219/00891—Feeding or evacuation
- B01J2219/00894—More than two inlets
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00781—Aspects relating to microreactors
- B01J2219/00891—Feeding or evacuation
- B01J2219/00896—Changing inlet or outlet cross-section, e.g. pressure-drop compensation
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
- B01J2219/00781—Aspects relating to microreactors
- B01J2219/00891—Feeding or evacuation
- B01J2219/00898—Macro-to-Micro (M2M)
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0809—Geometry, shape and general structure rectangular shaped
- B01L2300/0816—Cards, e.g. flat sample carriers usually with flow in two horizontal directions
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
- B01L2300/0864—Configuration of multiple channels and/or chambers in a single devices comprising only one inlet and multiple receiving wells, e.g. for separation, splitting
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2300/00—Additional constructional details
- B01L2300/08—Geometry, shape and general structure
- B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
- B01L2300/0867—Multiple inlets and one sample wells, e.g. mixing, dilution
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
- B01L2400/08—Regulating or influencing the flow resistance
- B01L2400/084—Passive control of flow resistance
- B01L2400/086—Passive control of flow resistance using baffles or other fixed flow obstructions
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- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Health & Medical Sciences (AREA)
- Analytical Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Dispersion Chemistry (AREA)
- Clinical Laboratory Science (AREA)
- Hematology (AREA)
- Immunology (AREA)
- General Physics & Mathematics (AREA)
- Biochemistry (AREA)
- Pathology (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Physics & Mathematics (AREA)
- Feeding, Discharge, Calcimining, Fusing, And Gas-Generation Devices (AREA)
- Physical Or Chemical Processes And Apparatus (AREA)
- Treatment Of Liquids With Adsorbents In General (AREA)
- Peptides Or Proteins (AREA)
- Automatic Analysis And Handling Materials Therefor (AREA)
Abstract
Description
式中、c(t)は、時間の関数としての種の質量分率である。これらの値から、容積変動(σv 2)は、
を用いて計算される。ピーク幅の尺度として、σt 2の代わりに(Fの情報を含有する)σv 2を使用することにより、流量が観測された(時間ベースの)ピーク幅に与える影響を排除する。
シミュレーションの最初のセットでは、検討された4種類の分配器のうちのいずれが、目詰まりのない状態で最高の性能を発揮するのかを判断するのが目標であった。図2は、検討された4種類の分配器のいずれかに於ける溶出の瞬間の種バンドのフレーム化された画像を示す。暗い部分は、最大濃度に対応する点線で囲まれた暗い部分を除いて、一般的に最小濃度を示す。より明るい部分は中間濃度に対応する。図3は、モニタラインに記録された対応する時間応答(ピーク)を示す。
式中、αは、管の形状に依存する定数(2つの平行板の間に形成される流路ではα=1/105)、β=15πDm/Fである。
Claims (14)
- 流体の流れを、小さい方の流体プラグから幅の広い方の流体プラグに分配するための分配器(100)であって、流入口(110)および複数の流出口(120)と、前記流入口(110)と前記複数の流出口(120)の間の流路構造(130)と、を備え、前記流路構造(130)は、交互分岐流路下部構造(132)と、共通流路下部構造(134)と、を備え、前記下部構造(132、134)は、分岐流路下部構造(132)とは異なる流路を出る流体が、後続の共通流路下部構造(134)内で混合するように配置されることにより、前記分岐流路下部構造(132)の流路は、端部で前記後続の共通流路下部構造(134)に接触しないように配置される、分配器(100)。
- 前記共通流路下部構造(134)は、長軸が前記構造のネット順方向の流れに略垂直であり、前記共通流路下部構造(134)の端部は、前記長軸の終点に対応している、請求項1に記載の分配器(100)。
- 少なくとも1つの共通流路下部構造(134)は、相互に離間して配置される複数の柱要素で満たされる共通流路を備える、請求項1または2に記載の分配器(100)。
- 少なくとも1つの共通流路内の前記複数の柱要素は、偶数列に整列する柱要素であり、n列ごとの異なる柱間要素空間の中心線の半径方向の位置が、先の分岐する流路の出口と一致する一方、n−1列ごとの異なる柱間要素空間の中心線の半径方向の位置が、次の列の柱の中心線と一致する、請求項3に記載の分配器(100)。
- 前記各共通流路下部構造(132)は、相互に離間して配置される複数の柱要素で満たされている、請求項3または4に記載の分配器(100)。
- 各共通流路について、前記柱要素が、偶数n列に整列し、n列ごとの異なる柱間要素空間の中心線の半径方向の位置が、先の分岐する流路の出口と一致する一方、n−1列ごとの異なる柱間要素空間の中心線の半径方向の位置が、次の列の柱の中心線と一致する、請求項5に記載の分配器(100)。
- 前記入口(110)付近の共通流路下部構造(134)内の柱要素の列の数が、前記出口(120)付近の共通流路下部構造(134)内の柱要素の列の数よりも多い、請求項6に記載の分配器(100)。
- 前記柱構造が、矩形、ひし形、または楕円形である、請求項3〜7のいずれか一項に記載の分配器(100)。
- 前記共通流路下部構造(134)の共通流路内には柱構造が存在しない、請求項1または2に記載の分配器(100)。
- 流体出力の数は(2m)であり、mは自然数である、請求項1〜9のいずれか1項に記載の分配器(100)。
- 請求項1〜10のいずれか1項に記載の分配器(100)を備える、ミクロ流体構造。
- クロマトグラフィシステムの分離構造である、請求項11に記載のミクロ流体構造。
- 請求項11または12に記載のミクロ流体構造を備える、クロマトグラフィシステム。
- 請求項1〜10のいずれか一項に記載の流れ分配器(100)、または請求項11もしくは12に記載のミクロ流体構造を備える、化学反応器。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP17164445.3 | 2017-03-31 | ||
EP17164445.3A EP3381531A1 (en) | 2017-03-31 | 2017-03-31 | Flow distributor |
PCT/EP2018/058300 WO2018178337A1 (en) | 2017-03-31 | 2018-03-30 | Flow distributor |
Publications (3)
Publication Number | Publication Date |
---|---|
JP2020515392A true JP2020515392A (ja) | 2020-05-28 |
JP2020515392A5 JP2020515392A5 (ja) | 2021-05-06 |
JP7126512B2 JP7126512B2 (ja) | 2022-08-26 |
Family
ID=58536722
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP2019553319A Active JP7126512B2 (ja) | 2017-03-31 | 2018-03-30 | 流れ分配器 |
Country Status (10)
Country | Link |
---|---|
US (1) | US11207682B2 (ja) |
EP (2) | EP3381531A1 (ja) |
JP (1) | JP7126512B2 (ja) |
KR (1) | KR102368174B1 (ja) |
CN (1) | CN110913967B (ja) |
AU (1) | AU2018246354A1 (ja) |
CA (1) | CA3058034A1 (ja) |
DK (1) | DK3600594T3 (ja) |
SG (1) | SG11201908991VA (ja) |
WO (1) | WO2018178337A1 (ja) |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
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JP2005517197A (ja) * | 2002-02-13 | 2005-06-09 | ナノストリーム・インコーポレイテッド | マイクロ流体分離カラム装置および組立方法 |
WO2009123009A1 (ja) * | 2008-03-31 | 2009-10-08 | 国立大学法人京都大学 | 流体分配装置、マイクロプラント、流体分配装置の設計方法及び流路閉塞検知方法 |
JP2012508643A (ja) * | 2008-09-29 | 2012-04-12 | コーニング インコーポレイテッド | 多流路型マイクロリアクタ・デザイン |
JP2016539331A (ja) * | 2013-11-22 | 2016-12-15 | ザ ジェネラル ホスピタル コーポレイション | 粒子クラスタを単離するためのマイクロ流体方法およびシステム |
Family Cites Families (15)
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DE3613683A1 (de) * | 1986-04-23 | 1987-11-05 | Liebisch Geb | Vorrichtung fuer die gesteuerte verteilung stroemungsfaehiger medien |
EP0264581A1 (de) * | 1986-10-02 | 1988-04-27 | GebràDer Sulzer Aktiengesellschaft | Vorrichtung zur Flüssigkeitsverteilung für Stoff- und Wärmeaustauschkolonnen |
AU617869B2 (en) * | 1988-11-03 | 1991-12-05 | Koch (Cyprus) Limited | Liquid distributor assembly for packed tower |
ATA166091A (de) * | 1991-08-23 | 1996-02-15 | Faigle Heinz Kg | Füllkörper |
TW293783B (ja) * | 1995-06-16 | 1996-12-21 | Ciba Geigy Ag | |
AU2001261462A1 (en) * | 2000-05-12 | 2001-11-26 | University Of Cincinnati | Structurally programmable microfluidic systems |
GB2366529A (en) * | 2000-09-11 | 2002-03-13 | Univ Sheffield | Fluidic control valve for an assembly containing a plurality of microreactors |
ES2378144T3 (es) * | 2001-05-17 | 2012-04-09 | Amalgamated Research, Inc. | Dispositivo fractal para aplicaciones de mezcla y de reactores |
DE10141526A1 (de) * | 2001-08-24 | 2003-04-17 | Zae Bayern Bayerisches Zentrum Fuer Angewandte Energieforschung Ev | Kleinstflüssigkeitsmengenverteiler |
US6863121B2 (en) * | 2002-04-16 | 2005-03-08 | Shell Oil Company | Flow distributor for an alkylation reactor or heat exchanger |
CN100500296C (zh) * | 2008-04-28 | 2009-06-17 | 上海应用技术学院 | 流量可调的点动式计量分配器 |
CN201259475Y (zh) * | 2008-08-06 | 2009-06-17 | 四川美生科技有限公司 | 流体定量分配器 |
US8802019B2 (en) * | 2010-12-21 | 2014-08-12 | Basf Se | Reactor for carrying out an autothermal gas-phase dehydrogenation |
CN104624148B (zh) * | 2014-12-19 | 2016-06-08 | 天津大学 | 带收集槽式液体分布器 |
CN204709866U (zh) * | 2015-06-18 | 2015-10-21 | 江苏汉邦科技有限公司 | 一种新型流动相分配器 |
-
2017
- 2017-03-31 EP EP17164445.3A patent/EP3381531A1/en not_active Withdrawn
-
2018
- 2018-03-30 EP EP18713964.7A patent/EP3600594B1/en active Active
- 2018-03-30 JP JP2019553319A patent/JP7126512B2/ja active Active
- 2018-03-30 CA CA3058034A patent/CA3058034A1/en active Pending
- 2018-03-30 CN CN201880030758.6A patent/CN110913967B/zh active Active
- 2018-03-30 KR KR1020197032202A patent/KR102368174B1/ko active IP Right Grant
- 2018-03-30 AU AU2018246354A patent/AU2018246354A1/en not_active Abandoned
- 2018-03-30 WO PCT/EP2018/058300 patent/WO2018178337A1/en active Application Filing
- 2018-03-30 DK DK18713964.7T patent/DK3600594T3/da active
- 2018-03-30 US US16/499,434 patent/US11207682B2/en active Active
- 2018-03-30 SG SG11201908991V patent/SG11201908991VA/en unknown
Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2005517197A (ja) * | 2002-02-13 | 2005-06-09 | ナノストリーム・インコーポレイテッド | マイクロ流体分離カラム装置および組立方法 |
WO2009123009A1 (ja) * | 2008-03-31 | 2009-10-08 | 国立大学法人京都大学 | 流体分配装置、マイクロプラント、流体分配装置の設計方法及び流路閉塞検知方法 |
JP2012508643A (ja) * | 2008-09-29 | 2012-04-12 | コーニング インコーポレイテッド | 多流路型マイクロリアクタ・デザイン |
JP2016539331A (ja) * | 2013-11-22 | 2016-12-15 | ザ ジェネラル ホスピタル コーポレイション | 粒子クラスタを単離するためのマイクロ流体方法およびシステム |
Also Published As
Publication number | Publication date |
---|---|
AU2018246354A1 (en) | 2019-11-14 |
US11207682B2 (en) | 2021-12-28 |
KR102368174B1 (ko) | 2022-02-28 |
DK3600594T3 (da) | 2021-08-23 |
EP3381531A1 (en) | 2018-10-03 |
EP3600594B1 (en) | 2021-06-02 |
EP3600594A1 (en) | 2020-02-05 |
CN110913967A (zh) | 2020-03-24 |
JP7126512B2 (ja) | 2022-08-26 |
CA3058034A1 (en) | 2018-10-04 |
CN110913967B (zh) | 2022-04-22 |
KR20200021046A (ko) | 2020-02-27 |
SG11201908991VA (en) | 2019-10-30 |
US20200215543A1 (en) | 2020-07-09 |
WO2018178337A1 (en) | 2018-10-04 |
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