CN110913967B - 流动分配器 - Google Patents

流动分配器 Download PDF

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Publication number
CN110913967B
CN110913967B CN201880030758.6A CN201880030758A CN110913967B CN 110913967 B CN110913967 B CN 110913967B CN 201880030758 A CN201880030758 A CN 201880030758A CN 110913967 B CN110913967 B CN 110913967B
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China
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distributor
channel
fluid
dispenser
common channel
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CN201880030758.6A
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Chinese (zh)
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CN110913967A (zh
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G·德斯米特
S·杰斯伯斯
S·德雷德
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Pharmafluidics NV
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Pharmafluidics NV
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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J19/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J19/0093—Microreactors, e.g. miniaturised or microfabricated reactors
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F25/00—Flow mixers; Mixers for falling materials, e.g. solid particles
    • B01F25/40—Static mixers
    • B01F25/41—Mixers of the fractal type
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/30—Micromixers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F33/00—Other mixers; Mixing plants; Combinations of mixers
    • B01F33/30—Micromixers
    • B01F33/301—Micromixers using specific means for arranging the streams to be mixed, e.g. channel geometries or dispositions
    • B01F33/3012—Interdigital streams, e.g. lamellae
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502707—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the manufacture of the container or its components
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502746—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means for controlling flow resistance, e.g. flow controllers, baffles or throttle valves
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/60—Construction of the column
    • G01N30/6004—Construction of the column end pieces
    • G01N30/6017—Fluid distributors
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F2101/00—Mixing characterised by the nature of the mixed materials or by the application field
    • B01F2101/2204—Mixing chemical components in generals in order to improve chemical treatment or reactions, independently from the specific application
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F2101/00—Mixing characterised by the nature of the mixed materials or by the application field
    • B01F2101/23—Mixing of laboratory samples e.g. in preparation of analysing or testing properties of materials
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00889—Mixing
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00891—Feeding or evacuation
    • B01J2219/00894—More than two inlets
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00891—Feeding or evacuation
    • B01J2219/00896—Changing inlet or outlet cross-section, e.g. pressure-drop compensation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2219/00—Chemical, physical or physico-chemical processes in general; Their relevant apparatus
    • B01J2219/00781—Aspects relating to microreactors
    • B01J2219/00891—Feeding or evacuation
    • B01J2219/00898—Macro-to-Micro (M2M)
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0816—Cards, e.g. flat sample carriers usually with flow in two horizontal directions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0864—Configuration of multiple channels and/or chambers in a single devices comprising only one inlet and multiple receiving wells, e.g. for separation, splitting
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0867—Multiple inlets and one sample wells, e.g. mixing, dilution
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/08—Regulating or influencing the flow resistance
    • B01L2400/084—Passive control of flow resistance
    • B01L2400/086—Passive control of flow resistance using baffles or other fixed flow obstructions

Landscapes

  • Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Hematology (AREA)
  • Clinical Laboratory Science (AREA)
  • Biochemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Organic Chemistry (AREA)
  • Feeding, Discharge, Calcimining, Fusing, And Gas-Generation Devices (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Peptides Or Proteins (AREA)
CN201880030758.6A 2017-03-31 2018-03-30 流动分配器 Active CN110913967B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP17164445.3 2017-03-31
EP17164445.3A EP3381531A1 (en) 2017-03-31 2017-03-31 Flow distributor
PCT/EP2018/058300 WO2018178337A1 (en) 2017-03-31 2018-03-30 Flow distributor

Publications (2)

Publication Number Publication Date
CN110913967A CN110913967A (zh) 2020-03-24
CN110913967B true CN110913967B (zh) 2022-04-22

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Family Applications (1)

Application Number Title Priority Date Filing Date
CN201880030758.6A Active CN110913967B (zh) 2017-03-31 2018-03-30 流动分配器

Country Status (10)

Country Link
US (1) US11207682B2 (enExample)
EP (2) EP3381531A1 (enExample)
JP (1) JP7126512B2 (enExample)
KR (1) KR102368174B1 (enExample)
CN (1) CN110913967B (enExample)
AU (1) AU2018246354A1 (enExample)
CA (1) CA3058034A1 (enExample)
DK (1) DK3600594T3 (enExample)
SG (1) SG11201908991VA (enExample)
WO (1) WO2018178337A1 (enExample)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BE1028976B1 (nl) 2020-12-30 2022-08-01 Pharmafluidics N V Pilaarstructuren

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3613683C2 (enExample) * 1986-04-23 1990-01-04 Gebr. Liebisch, 4800 Bielefeld, De
WO2001088525A1 (en) * 2000-05-12 2001-11-22 University Of Cincinnati Structurally programmable microfluidic systems
GB2366529A (en) * 2000-09-11 2002-03-13 Univ Sheffield Fluidic control valve for an assembly containing a plurality of microreactors
CN1646217A (zh) * 2002-04-16 2005-07-27 国际壳牌研究有限公司 用于烷化反应器或热交换器的流量分配器
CN101264458A (zh) * 2008-04-28 2008-09-17 上海应用技术学院 流量可调的点动式计量分配器
EP2273180A1 (en) * 2008-03-31 2011-01-12 Kyoto University Fluid distribution device, micro plant, method of designing fluid distribution device, and method of detecting clogging of flow passage

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0264581A1 (de) * 1986-10-02 1988-04-27 GebràœDer Sulzer Aktiengesellschaft Vorrichtung zur Flüssigkeitsverteilung für Stoff- und Wärmeaustauschkolonnen
AU617869B2 (en) * 1988-11-03 1991-12-05 Koch (Cyprus) Limited Liquid distributor assembly for packed tower
ATA166091A (de) * 1991-08-23 1996-02-15 Faigle Heinz Kg Füllkörper
TW293783B (enExample) * 1995-06-16 1996-12-21 Ciba Geigy Ag
ATE534457T1 (de) * 2001-05-17 2011-12-15 Amalgamated Res Inc Fraktalstruktur zum mischen von mindestens zwei fluiden
DE10141526A1 (de) * 2001-08-24 2003-04-17 Zae Bayern Bayerisches Zentrum Fuer Angewandte Energieforschung Ev Kleinstflüssigkeitsmengenverteiler
AU2003213071A1 (en) * 2002-02-13 2003-09-04 Nanostream, Inc. Microfluidic separation column devices and fabrication methods
CN201259475Y (zh) * 2008-08-06 2009-06-17 四川美生科技有限公司 流体定量分配器
EP2172260A1 (en) * 2008-09-29 2010-04-07 Corning Incorporated Multiple flow path microfluidic devices
US8802019B2 (en) * 2010-12-21 2014-08-12 Basf Se Reactor for carrying out an autothermal gas-phase dehydrogenation
CA2930430A1 (en) * 2013-11-22 2015-05-28 The General Hospital Corporation Microfluidic methods and systems for isolating particle clusters
CN104624148B (zh) * 2014-12-19 2016-06-08 天津大学 带收集槽式液体分布器
CN204709866U (zh) * 2015-06-18 2015-10-21 江苏汉邦科技有限公司 一种新型流动相分配器

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3613683C2 (enExample) * 1986-04-23 1990-01-04 Gebr. Liebisch, 4800 Bielefeld, De
WO2001088525A1 (en) * 2000-05-12 2001-11-22 University Of Cincinnati Structurally programmable microfluidic systems
GB2366529A (en) * 2000-09-11 2002-03-13 Univ Sheffield Fluidic control valve for an assembly containing a plurality of microreactors
CN1646217A (zh) * 2002-04-16 2005-07-27 国际壳牌研究有限公司 用于烷化反应器或热交换器的流量分配器
EP2273180A1 (en) * 2008-03-31 2011-01-12 Kyoto University Fluid distribution device, micro plant, method of designing fluid distribution device, and method of detecting clogging of flow passage
CN101264458A (zh) * 2008-04-28 2008-09-17 上海应用技术学院 流量可调的点动式计量分配器

Also Published As

Publication number Publication date
DK3600594T3 (da) 2021-08-23
SG11201908991VA (en) 2019-10-30
US20200215543A1 (en) 2020-07-09
KR102368174B1 (ko) 2022-02-28
US11207682B2 (en) 2021-12-28
KR20200021046A (ko) 2020-02-27
WO2018178337A1 (en) 2018-10-04
EP3600594A1 (en) 2020-02-05
EP3600594B1 (en) 2021-06-02
CA3058034A1 (en) 2018-10-04
JP2020515392A (ja) 2020-05-28
AU2018246354A1 (en) 2019-11-14
JP7126512B2 (ja) 2022-08-26
CN110913967A (zh) 2020-03-24
EP3381531A1 (en) 2018-10-03

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