KR102348325B1 - 항암 조성물 - Google Patents

항암 조성물 Download PDF

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Publication number
KR102348325B1
KR102348325B1 KR1020177018240A KR20177018240A KR102348325B1 KR 102348325 B1 KR102348325 B1 KR 102348325B1 KR 1020177018240 A KR1020177018240 A KR 1020177018240A KR 20177018240 A KR20177018240 A KR 20177018240A KR 102348325 B1 KR102348325 B1 KR 102348325B1
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South Korea
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arn
solid dispersion
poly
meth
acrylate copolymer
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English (en)
Korean (ko)
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KR20170086657A (ko
Inventor
게르트 베르레크
Original Assignee
아라곤 파마슈티컬스, 인코포레이티드
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=52006905&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=KR102348325(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by 아라곤 파마슈티컬스, 인코포레이티드 filed Critical 아라곤 파마슈티컬스, 인코포레이티드
Publication of KR20170086657A publication Critical patent/KR20170086657A/ko
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis

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  • Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Physiology (AREA)
  • Nutrition Science (AREA)
  • Urology & Nephrology (AREA)
  • Oncology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
KR1020177018240A 2014-12-05 2015-12-03 항암 조성물 Active KR102348325B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP14196591.3 2014-12-05
EP14196591 2014-12-05
PCT/US2015/063667 WO2016090101A1 (en) 2014-12-05 2015-12-03 Anticancer compositions

Publications (2)

Publication Number Publication Date
KR20170086657A KR20170086657A (ko) 2017-07-26
KR102348325B1 true KR102348325B1 (ko) 2022-01-06

Family

ID=52006905

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020177018240A Active KR102348325B1 (ko) 2014-12-05 2015-12-03 항암 조성물

Country Status (31)

Country Link
US (3) US20170360707A1 (https=)
EP (2) EP3842034B1 (https=)
JP (1) JP6767368B2 (https=)
KR (1) KR102348325B1 (https=)
CN (2) CN106999430A (https=)
AR (1) AR102924A1 (https=)
AU (1) AU2015358493B2 (https=)
CA (1) CA2969661C (https=)
CL (1) CL2017001372A1 (https=)
CO (1) CO2017005573A2 (https=)
CR (1) CR20170217A (https=)
CY (1) CY1123856T1 (https=)
DK (1) DK3226842T3 (https=)
EA (1) EA035988B1 (https=)
ES (2) ES2839128T3 (https=)
HR (1) HRP20201902T1 (https=)
HU (1) HUE051888T2 (https=)
IL (1) IL252324B (https=)
LT (1) LT3226842T (https=)
MA (2) MA41108B1 (https=)
MD (1) MD3226842T2 (https=)
MX (1) MX384382B (https=)
NI (1) NI201700069A (https=)
PL (1) PL3226842T3 (https=)
PT (1) PT3226842T (https=)
RS (1) RS61466B1 (https=)
SG (1) SG11201704264UA (https=)
SI (1) SI3226842T1 (https=)
TW (1) TWI683662B (https=)
UA (1) UA121123C2 (https=)
WO (1) WO2016090101A1 (https=)

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Publication number Priority date Publication date Assignee Title
SG11201501870RA (en) 2012-09-26 2015-04-29 Aragon Pharmaceuticals Inc Anti-androgens for the treatment of non-metastatic castrate-resistant prostate cancer
WO2016090098A1 (en) 2014-12-05 2016-06-09 Aragon Pharmaceuticals, Inc. Anticancer compositions
ES3019912T3 (en) 2014-12-05 2025-05-21 Aragon Pharmaceuticals Inc Anticancer compositions
AU2018351714A1 (en) 2017-10-16 2020-04-30 Aragon Pharmaceuticals, Inc. Anti-androgens for the treatment of non-metastatic castration-resistant prostate cancer
JP7244536B2 (ja) * 2018-04-06 2023-03-22 キャプシュゲル・ベルジウム・エヌ・ヴィ メタクリル酸メチル－メタクリル酸コポリマーからなる低アスペクト比の粒子のための噴霧乾燥方法
WO2020144647A1 (en) 2019-01-10 2020-07-16 Aragon Pharmaceuticals, Inc. Pharmaceutical composition comprising apalutamide dispersed in apple sauce
AU2020215177A1 (en) 2019-01-30 2021-08-12 Janssen Pharmaceutica Nv Methods of treating prostate cancer based on molecular subtypes
TWI840496B (zh) 2019-01-30 2024-05-01 美商艾瑞岡醫藥公司 用於治療轉移性去勢敏感性前列腺癌之抗雄性激素
WO2020239478A1 (en) 2019-05-28 2020-12-03 Pharma Mar, S.A. Trabectedin for treating sarcomas based on genomic markers
EP4054572A1 (en) 2019-11-04 2022-09-14 Aragon Pharmaceuticals, Inc. Androgen receptor inhibitors for the treatment of non-metastatic castration-resistant prostate cancer in subjects with severe hepatic impairment
WO2021245285A1 (en) 2020-06-05 2021-12-09 Janssen Pharmaceutica Nv Methods of treating prostate cancer based on molecular subtypes
TW202228794A (zh) 2020-09-04 2022-08-01 美商艾瑞岡醫藥公司 用於治療前列腺癌之方法
WO2022195407A1 (en) 2021-03-19 2022-09-22 Aragon Pharmaceuticals, Inc. Methods for treating prostate cancer
WO2023152611A1 (en) 2022-02-11 2023-08-17 Aragon Pharmaceuticals, Inc. Apalutamide and relugolix for the treatment of prostate cancer
WO2023209555A1 (en) 2022-04-26 2023-11-02 Aragon Pharmaceuticals, Inc. Approved drug products and methods for treating prostate cancer
KR20250157532A (ko) 2023-03-16 2025-11-04 바이엘 컨수머 케어 악티엔게젤샤프트 호르몬 감수성 전립선암의 생화학적 재발이 있는 환자의 치료를 위한 안드로겐 수용체 길항제
WO2026052846A1 (en) 2024-09-09 2026-03-12 Synthon B.V. Pharmaceutical formulation comprising apalutamide

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1381358B1 (en) 2001-04-02 2006-05-03 Astrazeneca AB Solid pharmaceutical composition comprising 4'-cyano-trifluoro-3-(4-fluorophenylsulphonyl) -2-hydroxy-2-methylpropiono- m toluidide and pvp
WO2003077827A1 (en) * 2002-03-19 2003-09-25 Nippon Shinyaku Co., Ltd. Process for producing drug solid dispersion
CA2549572A1 (en) * 2003-12-15 2005-06-23 Council Of Scientific & Industrial Research Taste masked pharmaceutical compositions comprising bitter drug and ph sensitive polymer
LT2656842T (lt) * 2006-03-27 2016-09-26 The Regents Of The University Of California Androgeno receptoriaus moduliatorius, skirtas prostatos vėžio ir su androgeno receptoriumi susijusių ligų gydymui
WO2011103202A2 (en) * 2010-02-16 2011-08-25 Aragon Pharmaceuticals, Inc. Androgen receptor modulators and uses thereof
EP2721003B1 (en) * 2011-06-15 2018-01-03 The United States of America, as Represented by The Secretary, Department of Health and Human Services Nuclear receptor modulators and their use for the treatment and prevention of cancer
WO2013152342A1 (en) * 2012-04-06 2013-10-10 OSI Pharmaceuticals, LLC Anti-cancer mtor inhibitor and anti-androgen combination
EA201992010A1 (ru) 2012-06-07 2020-01-24 Арагон Фармасьютикалз, Инк. Кристаллическая форма а 4-[7-(6-циано-5-трифторметилпиридин-3-ил)-8-оксо-6-тиоксо-5,7-диазаспиро[3.4]окт-5-ил]-2-фтор-n-метилбензамида для лечения заболевания или состояния, связанного с активностью андрогенных рецепторов, включая рак простаты
US10668156B2 (en) 2012-06-22 2020-06-02 Basf Se Active-ingredient-containing solid dispersions based on diethylaminoethyl methacrylate copolymers
WO2014043208A1 (en) * 2012-09-11 2014-03-20 Medivation Prostate Therapeutics, Inc. Formulations of enzalutamide
SG11201501870RA (en) * 2012-09-26 2015-04-29 Aragon Pharmaceuticals Inc Anti-androgens for the treatment of non-metastatic castrate-resistant prostate cancer
SG10201907684PA (en) * 2013-01-15 2019-10-30 Aragon Pharmaceuticals Inc Androgen receptor modulator and uses thereof
CN112353762A (zh) * 2013-01-22 2021-02-12 霍夫曼-拉罗奇有限公司 具有改善的生物利用度的药物组合物
WO2014167428A2 (en) 2013-04-10 2014-10-16 Shilpa Medicare Limited Amorphous 4-(3-(4-cyano-3-(trifluoromethyl)phenyl)-5,5-dimethyl-4-oxo-2-thioxoimidazolidin-1-yl)-2-fluoro-n-methylbenzamide
CA2920317A1 (en) * 2013-08-12 2015-02-19 Tokai Pharmaceuticals, Inc. Biomarkers for treatment of neoplastic disorders using androgen-targeted therapies
CA2940984A1 (en) * 2014-02-05 2015-08-13 Lek Pharmaceuticals D.D. Solid pharmaceutical compositions of androgen receptor antagonists

Also Published As

Publication number Publication date
CO2017005573A2 (es) 2017-09-29
JP2017536401A (ja) 2017-12-07
EP3226842B1 (en) 2020-11-25
SG11201704264UA (en) 2017-06-29
JP6767368B2 (ja) 2020-10-14
PL3226842T3 (pl) 2021-07-12
IL252324B (en) 2021-10-31
EP3842034B1 (en) 2025-02-12
EP3842034A1 (en) 2021-06-30
HUE051888T2 (hu) 2021-03-29
ES3021508T3 (en) 2025-05-27
DK3226842T3 (da) 2021-01-25
ES2839128T3 (es) 2021-07-05
SI3226842T1 (sl) 2021-04-30
EP3226842A1 (en) 2017-10-11
BR112017011787A2 (pt) 2017-12-26
PT3226842T (pt) 2020-12-23
LT3226842T (lt) 2021-03-25
WO2016090101A1 (en) 2016-06-09
CN115837010A (zh) 2023-03-24
MA41108A (fr) 2016-06-09
MD3226842T2 (ro) 2021-03-31
NI201700069A (es) 2017-10-31
CA2969661A1 (en) 2016-06-09
MX384382B (es) 2025-03-14
CN115837010B (zh) 2025-03-14
AU2015358493A1 (en) 2017-06-08
EA035988B1 (ru) 2020-09-09
HRP20201902T1 (hr) 2021-07-23
US20220151931A1 (en) 2022-05-19
CY1123856T1 (el) 2022-05-27
MA55404A (fr) 2022-02-02
MA41108B1 (fr) 2021-03-31
EA201791252A1 (ru) 2017-10-31
US20170360707A1 (en) 2017-12-21
KR20170086657A (ko) 2017-07-26
CR20170217A (es) 2017-08-30
TW201632187A (zh) 2016-09-16
RS61466B1 (sr) 2021-03-31
CN106999430A (zh) 2017-08-01
US20240293321A1 (en) 2024-09-05
MX2017007201A (es) 2018-01-30
AR102924A1 (es) 2017-04-05
AU2015358493B2 (en) 2021-05-06
CA2969661C (en) 2023-04-25
UA121123C2 (uk) 2020-04-10
IL252324A0 (en) 2017-07-31
CL2017001372A1 (es) 2018-01-05
TWI683662B (zh) 2020-02-01

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