KR102342319B1 - Ca ix-표적 nir 염료 및 그의 용도 - Google Patents

Ca ix-표적 nir 염료 및 그의 용도 Download PDF

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KR102342319B1
KR102342319B1 KR1020187027616A KR20187027616A KR102342319B1 KR 102342319 B1 KR102342319 B1 KR 102342319B1 KR 1020187027616 A KR1020187027616 A KR 1020187027616A KR 20187027616 A KR20187027616 A KR 20187027616A KR 102342319 B1 KR102342319 B1 KR 102342319B1
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슈미스 에이. 쿨라라트네
프라빈 가가레
아난다 칸둘루르
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온 타겟 래보래토리스, 엘엘씨
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KR1020187027616A 2016-03-16 2017-03-16 Ca ix-표적 nir 염료 및 그의 용도 Active KR102342319B1 (ko)

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Application Number Priority Date Filing Date Title
US201662309412P 2016-03-16 2016-03-16
US62/309,412 2016-03-16
PCT/US2017/022824 WO2017161197A1 (en) 2016-03-16 2017-03-16 Ca ix-target nir dyes and their uses

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KR20180123216A KR20180123216A (ko) 2018-11-15
KR102342319B1 true KR102342319B1 (ko) 2021-12-23

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US (2) US10557854B2 (https=)
EP (1) EP3430383B1 (https=)
JP (1) JP7285537B2 (https=)
KR (1) KR102342319B1 (https=)
CN (1) CN109791107B (https=)
AU (1) AU2017234681B2 (https=)
BR (1) BR112018068142B1 (https=)
ES (1) ES2989466T3 (https=)
IL (1) IL261470B (https=)
MX (1) MX2018011130A (https=)
WO (2) WO2017161197A1 (https=)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11555821B2 (en) 2016-03-16 2023-01-17 On Target Laboratories, Inc. CA IX-NIR dyes and their uses
CN111225688B (zh) * 2017-08-22 2025-06-17 普渡研究基金会 靶向碳酸酐酶阳性癌症的基于fbsa的治疗和放射性成像缀合物
WO2019133914A1 (en) * 2017-12-29 2019-07-04 Wayne State University Method of treatment for solid tumors containing hypoxia and/or stroma features
WO2020131980A1 (en) * 2018-12-19 2020-06-25 Purdue Research Foundation Carbonic anhydrase inhibitors and antibiotics against multidrug resistant bacteria
CN110790724B (zh) * 2019-09-20 2023-01-31 中山大学 一种选择性碳酸酐酶抑制剂及其合成方法和应用
US20210353151A1 (en) * 2020-05-12 2021-11-18 On Target Laboratories, LLC Targeted fluorescent markers in combination with a flexible probe
EP4247436A4 (en) * 2020-11-18 2024-10-16 On Target Laboratories, LLC NEAR-INFRARED II PROBES AS HIGH-AFFINE TARGETING IMAGING AGENTS AND USES THEREOF
US20240000946A1 (en) * 2020-12-03 2024-01-04 Vilnius University Carbonic anhydrase inhibitors synthesized on interconnecting linker chains
CA3217981A1 (en) * 2021-05-14 2022-11-17 Philip Low Folate receptor-targeted conjugates with brush border membrane enzyme-cleavable linkers and methods of use in imaging and treating cancer
WO2023081301A1 (en) * 2021-11-05 2023-05-11 On Target Laboratories, LLC Fibroblast activation protein targeted dyes their related uses
CA3243979A1 (en) * 2022-02-11 2025-04-30 C-Biomex Co., Ltd. Peptide ligand targeting carbonic anhydrase IX, peptide construction comprising it, and associated uses
EP4562099A1 (en) 2022-07-28 2025-06-04 Bracco Imaging SPA Ca-ix targeting fluorescent probes
CN119325492A (zh) 2022-07-28 2025-01-17 伯拉考成像股份公司 靶向ca-ix的荧光探针
CN119490505A (zh) * 2023-08-16 2025-02-21 新斗生物科技(苏州)有限公司 一种含叶酸类化合物的组合物及近红外荧光捕获系统

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US7833734B2 (en) 2002-11-26 2010-11-16 Institute Of Virology Of The Slovak Academy Of Sciences CA IX-specific inhibitors
WO2006137092A1 (en) * 2005-06-23 2006-12-28 Supuran Claudiu T Fluorescent sulfonamide derivatives having carbonic anhydrase inhibiting activity and their use as theapeutic and diagnostic agents
US11077212B2 (en) * 2010-08-24 2021-08-03 H. Lee Moffitt Cancer Center And Research Institute, Inc. Molecular imaging of cancer cells in vivo
WO2012154884A2 (en) 2011-05-09 2012-11-15 The Regents Of The University Of California Method and compositions to promote plant growth in metal contaminated environments
CN103687854A (zh) * 2011-05-09 2014-03-26 文森医学公司 碳酸酐酶靶向剂及其使用方法
WO2013036543A2 (en) * 2011-09-10 2013-03-14 H. Lee Moffitt Cancer Center And Research Institute, Inc. Molecular imaging of cancer cells in vivo
EP2855520B1 (en) 2012-06-04 2018-09-26 Novartis AG Site-specific labeling methods and molecules produced thereby
LT6064B (lt) * 2012-10-15 2014-08-25 Vilniaus Universitetas Fluorinti benzensulfonamidai kaip karboanhidrazės inhibitoriai
ITRM20130138A1 (it) 2013-03-07 2014-09-08 Consiglio Nazionale Ricerche Assemblato comprendente un assorbitore della luce nel vicino infrarosso legato covalentemente ad un inibitore dell'anidrasi carbonica
WO2014149069A1 (en) * 2013-03-15 2014-09-25 Purdue Research Foundation Synthesis and composition of amino acid linking groups conjugated to compounds used for the targeted imaging of tumors
ES2735348T3 (es) * 2014-02-03 2019-12-18 Eidgenoessiche Technische Hochschule Zuerich Conjugados de fármaco de molécula pequeña
US9808538B2 (en) 2015-09-09 2017-11-07 On Target Laboratories, LLC PSMA-targeted NIR dyes and their uses

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
Groves Kevin 외. Bioorganic & Medicinal Chemistry Letters. Vol. 22(1), pp. 653-657
Nikilaus Krall 외. Angewandte Chemie International Edition. Vol. 53(16), pp. 4231-4235
Tai-Cheng Hou 외. Chemical Science. Vol. 6(8), pp. 4643-4649

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US20200174009A1 (en) 2020-06-04
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