KR102321482B1 - 개선된 치료 지수를 갖는 암포테리신 b 유도체 - Google Patents

개선된 치료 지수를 갖는 암포테리신 b 유도체 Download PDF

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KR102321482B1
KR102321482B1 KR1020167011985A KR20167011985A KR102321482B1 KR 102321482 B1 KR102321482 B1 KR 102321482B1 KR 1020167011985 A KR1020167011985 A KR 1020167011985A KR 20167011985 A KR20167011985 A KR 20167011985A KR 102321482 B1 KR102321482 B1 KR 102321482B1
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KR20160068861A (ko
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마틴 디. 버크
스티븐 데이비스
브리스 이. 우노
저스틴 스트루블
이안 데일리
케이틀린 씨. 그레이
데이비드 엠. 냅
푸린 왕
나가르주나 팔리암
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더 보오드 오브 트러스티스 오브 더 유니버시티 오브 일리노이즈
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/90—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Agronomy & Crop Science (AREA)
  • Zoology (AREA)
  • Environmental Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Dentistry (AREA)
  • Plant Pathology (AREA)
  • Pest Control & Pesticides (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
KR1020167011985A 2013-10-07 2014-10-06 개선된 치료 지수를 갖는 암포테리신 b 유도체 Active KR102321482B1 (ko)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR1020217035284A KR102548341B1 (ko) 2013-10-07 2014-10-06 개선된 치료 지수를 갖는 암포테리신 b 유도체

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201361887729P 2013-10-07 2013-10-07
US61/887,729 2013-10-07
US201462045956P 2014-09-04 2014-09-04
US62/045,956 2014-09-04
PCT/US2014/059334 WO2015054148A1 (en) 2013-10-07 2014-10-06 Amphotericin b derivatives with improved therapeutic index

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KR1020217035284A Division KR102548341B1 (ko) 2013-10-07 2014-10-06 개선된 치료 지수를 갖는 암포테리신 b 유도체

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KR20160068861A KR20160068861A (ko) 2016-06-15
KR102321482B1 true KR102321482B1 (ko) 2021-11-02

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KR1020167011985A Active KR102321482B1 (ko) 2013-10-07 2014-10-06 개선된 치료 지수를 갖는 암포테리신 b 유도체
KR1020217035284A Active KR102548341B1 (ko) 2013-10-07 2014-10-06 개선된 치료 지수를 갖는 암포테리신 b 유도체

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US (4) US10323057B2 (enExample)
EP (1) EP3055030B1 (enExample)
JP (2) JP6600303B2 (enExample)
KR (2) KR102321482B1 (enExample)
CN (2) CN105848721B (enExample)
AU (2) AU2014332214B2 (enExample)
CA (1) CA2925904C (enExample)
DK (1) DK3055030T3 (enExample)
ES (1) ES2682328T3 (enExample)
SG (1) SG11201602570WA (enExample)
WO (1) WO2015054148A1 (enExample)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2014332214B2 (en) 2013-10-07 2019-10-03 The Board Of Trustees Of The University Of Illinois Amphotericin B derivatives with improved therapeutic index
EA037093B1 (ru) * 2014-06-12 2021-02-04 Сионоги Энд Ко., Лтд. Производное полиенового макролида
EP3242554A4 (en) * 2015-01-08 2018-06-06 The Board of Trustees of the University of Illionis Concise synthesis of urea derivatives of amphotericin b
ES2880029T3 (es) 2015-04-15 2021-11-23 Sfunga Therapeutics Inc Derivados de anfotericina B
WO2017100171A1 (en) * 2015-12-08 2017-06-15 Kalyra Pharmaceuticals, Inc. Antifungal compounds and methods
PT3439668T (pt) * 2016-04-08 2024-08-12 Univ Illinois Restauração da fisiologia da superfície das vias aéreas mediada por pequenas moléculas no epitélio pulmonar da fibrose quística humana
WO2018106571A1 (en) * 2016-12-06 2018-06-14 Kalyra Pharmaceuticals, Inc. Antifungal compounds and methods
JP7477177B2 (ja) 2018-09-07 2024-05-01 ザ ボード オブ トラスティーズ オブ ザ ユニヴァーシティ オブ イリノイ 毒性が低減されたハイブリッドアムホテリシンｂ誘導体
AU2020325054A1 (en) * 2019-08-08 2022-03-03 The Board Of Trustees Of The University Of Illinois Hybrid amphotericin b derivatives with reduced toxicity
CN111909226A (zh) * 2020-08-11 2020-11-10 深圳市儿童医院 一种葡萄糖酸修饰的两性霉素b衍生物及其用途
CN119365218A (zh) 2022-03-21 2025-01-24 伊利诺伊大学评议会 包含脂质包覆的两性霉素b晶体的离子通道假体组合物
CA3261962A1 (en) * 2022-07-08 2024-01-11 The Board Of Trustees Of The University Of Illinois TRANSFER OF C2 EPIMERIZED SUGARS TO AGLYCONIC AMPHOTEROCIBN B

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070238746A1 (en) 2006-04-06 2007-10-11 Trixi Brandl Thiazolyl-dihydro-chinazoline

Family Cites Families (11)

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Publication number Priority date Publication date Assignee Title
EP0431870A1 (en) * 1989-12-08 1991-06-12 Beecham Group p.l.c. Amphotericin B derivatives
WO1993016090A1 (en) * 1992-02-12 1993-08-19 Smithkline Beecham Plc Amphotericin b derivative
AU2006206952B2 (en) 2005-01-24 2011-08-18 Microbial Chemistry Research Foundation Anti-penicillin resistant pneumococci agent and novel 16-membered ring macrolide derivative
RU2007138884A (ru) 2005-03-23 2009-04-27 Консехо Супериор Де Инвестигасьонес Сьентификас (Es) Полиеновые антибиотики, композиции, содержащие указанные антибиотики, способ и микроорганизмы, применяемые для их получения, и их применение
US20090186838A1 (en) * 2006-02-23 2009-07-23 Eidgenössische Technische Hochschule Zürich Amphotericin Derivatives
DE102006060008A1 (de) 2006-12-19 2008-06-26 Patent-Treuhand-Gesellschaft für elektrische Glühlampen mbH Lampe mit verbesserter Quetschungsgeometrie
GB0712881D0 (en) * 2007-07-03 2007-08-15 Biosergen As Compounds
MX365184B (es) 2010-12-21 2019-05-21 Centro De Investig Y De Estudios Avanzados Del I P N Nuevos compuestos analogos de la anfotericina y composiciones farmaceuticas que los contienen.
WO2014165676A1 (en) 2013-04-03 2014-10-09 The Board Of Trustees Of The University Of Illinois Amphotericin b derivative with reduced toxicity
AU2014332214B2 (en) 2013-10-07 2019-10-03 The Board Of Trustees Of The University Of Illinois Amphotericin B derivatives with improved therapeutic index
ES2880029T3 (es) 2015-04-15 2021-11-23 Sfunga Therapeutics Inc Derivados de anfotericina B

Patent Citations (1)

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Publication number Priority date Publication date Assignee Title
US20070238746A1 (en) 2006-04-06 2007-10-11 Trixi Brandl Thiazolyl-dihydro-chinazoline

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
A.N.Tevyashova et al., Antimicrobial Agents and Chemotherapy, 2013, Vol.57, No.8, 3815-3822쪽
B. Byrne et al., 'Biosynthesis of Deoxyamphotericins and Deoxyamphoteronolides by Engineered Strains of Streptomyces nodosus', Chemistry & Biology, 2003, Vol. 10, 1215-1224쪽*
D.M.GEISER, "Antifungal design: The toxicity-resistance yin-yang", NATURE CHEMICAL BIOLOGY, 2015, vol.11, no.7, pp.453-454
S.A.DAVIS et al., "C3-OH of Amphotericin B Plays an Important Role in Ion Conductance", J. of the American Chem. Soc., 2015, vol.137, no.48, pp.15102-15104

Also Published As

Publication number Publication date
KR102548341B1 (ko) 2023-06-26
AU2019279928A1 (en) 2020-01-16
DK3055030T3 (en) 2018-08-13
CN110407898A (zh) 2019-11-05
CN110407898B (zh) 2023-12-01
JP2020019804A (ja) 2020-02-06
JP6600303B2 (ja) 2019-10-30
EP3055030A4 (en) 2017-03-15
US11970512B2 (en) 2024-04-30
JP2016531894A (ja) 2016-10-13
US20220056066A1 (en) 2022-02-24
KR20160068861A (ko) 2016-06-15
AU2014332214B2 (en) 2019-10-03
CN105848721A (zh) 2016-08-10
AU2019279928B2 (en) 2020-07-23
US20200002368A1 (en) 2020-01-02
NZ757647A (en) 2021-06-25
CA2925904A1 (en) 2015-04-16
US11028114B2 (en) 2021-06-08
CN105848721B (zh) 2019-08-23
CA2925904C (en) 2021-11-23
US20160215012A1 (en) 2016-07-28
KR20210132248A (ko) 2021-11-03
WO2015054148A1 (en) 2015-04-16
NZ719529A (en) 2021-06-25
JP7469862B2 (ja) 2024-04-17
EP3055030B1 (en) 2018-05-02
US10323057B2 (en) 2019-06-18
US11117920B2 (en) 2021-09-14
EP3055030A1 (en) 2016-08-17
SG11201602570WA (en) 2016-04-28
AU2014332214A1 (en) 2016-05-19
ES2682328T3 (es) 2018-09-20
US20190345187A1 (en) 2019-11-14

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