KR102259117B1 - 시트 성형체 및 지혈재 - Google Patents

시트 성형체 및 지혈재 Download PDF

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Publication number
KR102259117B1
KR102259117B1 KR1020147031716A KR20147031716A KR102259117B1 KR 102259117 B1 KR102259117 B1 KR 102259117B1 KR 1020147031716 A KR1020147031716 A KR 1020147031716A KR 20147031716 A KR20147031716 A KR 20147031716A KR 102259117 B1 KR102259117 B1 KR 102259117B1
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South Korea
Prior art keywords
molded article
fibrinogen
thrombin
polymer
laminated sheet
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KR1020147031716A
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English (en)
Korean (ko)
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KR20150020536A (ko
Inventor
유카코 가게야마
겐타로 후지나가
아유코 야마구치
유스케 아키야마
아키토시 오오노
스스무 혼다
마코토 사타케
히로아키 가네코
다카유키 이마무라
료이치 가와무라
마사키 히라시마
Original Assignee
데이진 가부시키가이샤
데이진 화-마 가부시키가이샤
케이엠 바이올로직스 가부시키가이샤
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Publication of KR20150020536A publication Critical patent/KR20150020536A/ko
Application granted granted Critical
Publication of KR102259117B1 publication Critical patent/KR102259117B1/ko
Assigned to 데이진 가부시키가이샤 reassignment 데이진 가부시키가이샤 권리지분의 전부이전등록 Assignors: 데이진 화-마 가부시키가이샤
Assigned to 케이엠 바이올로직스 가부시키가이샤 reassignment 케이엠 바이올로직스 가부시키가이샤 권리지분의 전부이전등록 Assignors: 데이진 가부시키가이샤
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F13/00—Bandages or dressings; Absorbent pads
    • A61F13/00051—Accessories for dressings
    • A61F13/00063—Accessories for dressings comprising medicaments or additives, e.g. odor control, PH control, debriding, antimicrobic
    • A—HUMAN NECESSITIES
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    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F13/00—Bandages or dressings; Absorbent pads
    • A61F13/02—Adhesive bandages or dressings
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    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/36—Blood coagulation or fibrinolysis factors
    • A61K38/363—Fibrinogen
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K38/43—Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46—Hydrolases (3)
    • A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
    • A61K38/482—Serine endopeptidases (3.4.21)
    • A61K38/4833—Thrombin (3.4.21.5)
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    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
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    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
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    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
    • A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
    • A61L26/0028—Polypeptides; Proteins; Degradation products thereof
    • A61L26/0042—Fibrin; Fibrinogen
    • A—HUMAN NECESSITIES
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    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
    • A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
    • A61L26/0052—Mixtures of macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
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    • A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
    • A61L26/0061—Use of materials characterised by their function or physical properties
    • A61L26/0085—Porous materials, e.g. foams or sponges
    • A—HUMAN NECESSITIES
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    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
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    • A61F13/00—Bandages or dressings; Absorbent pads
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    • A61F2013/00463—Plasters use haemostatic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
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    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
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    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
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    • A61L2400/00—Materials characterised by their function or physical properties
    • A61L2400/04—Materials for stopping bleeding

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Materials Engineering (AREA)
  • Medicinal Chemistry (AREA)
  • Surgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Hematology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Vascular Medicine (AREA)
  • Dispersion Chemistry (AREA)
  • Zoology (AREA)
  • Diabetes (AREA)
  • Inorganic Chemistry (AREA)
  • Materials For Medical Uses (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Laminated Bodies (AREA)
  • Polymers & Plastics (AREA)
  • Medicinal Preparation (AREA)
KR1020147031716A 2012-05-14 2013-05-13 시트 성형체 및 지혈재 Active KR102259117B1 (ko)

Applications Claiming Priority (11)

Application Number Priority Date Filing Date Title
JP2012110394 2012-05-14
JP2012110393 2012-05-14
JPJP-P-2012-110391 2012-05-14
JP2012110392 2012-05-14
JPJP-P-2012-110393 2012-05-14
JP2012110391 2012-05-14
JPJP-P-2012-110392 2012-05-14
JPJP-P-2012-110394 2012-05-14
JPJP-P-2013-003273 2013-01-11
JP2013003273 2013-01-11
PCT/JP2013/063872 WO2013172472A1 (ja) 2012-05-14 2013-05-13 シート成形体および止血材

Publications (2)

Publication Number Publication Date
KR20150020536A KR20150020536A (ko) 2015-02-26
KR102259117B1 true KR102259117B1 (ko) 2021-05-31

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Application Number Title Priority Date Filing Date
KR1020147031716A Active KR102259117B1 (ko) 2012-05-14 2013-05-13 시트 성형체 및 지혈재

Country Status (23)

Country Link
US (2) US10485894B2 (https=)
EP (1) EP2851095B1 (https=)
JP (2) JP5844894B2 (https=)
KR (1) KR102259117B1 (https=)
CN (1) CN104271164B (https=)
AR (1) AR091031A1 (https=)
AU (1) AU2013261312B2 (https=)
BR (1) BR112014028471B8 (https=)
CA (1) CA2873162C (https=)
DK (1) DK2851095T3 (https=)
ES (1) ES2890098T3 (https=)
HU (1) HUE056396T2 (https=)
IL (1) IL235689B (https=)
MX (1) MX357254B (https=)
MY (1) MY173719A (https=)
NZ (1) NZ631084A (https=)
PH (1) PH12014502535B1 (https=)
PL (1) PL2851095T3 (https=)
RU (1) RU2669569C2 (https=)
SG (1) SG11201407549YA (https=)
TW (1) TWI584825B (https=)
WO (1) WO2013172472A1 (https=)
ZA (1) ZA201408258B (https=)

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AR091031A1 (es) * 2012-05-14 2014-12-30 Teijin Ltd Producto en planchas y material hemostatico
KR102576293B1 (ko) 2015-11-06 2023-09-08 에디컨인코포레이티드 압밀된 지혈 셀룰로오스 집합체
CA3016391C (en) * 2016-03-07 2024-06-04 Nippon Zoki Pharmaceutical Co., Ltd. Sustained drug release sheet for treating nerve injury
CN106267328B (zh) * 2016-09-20 2019-04-12 安徽思维特生物科技有限公司 一种聚己内酯-胎牛皮胶原纤维复合止血凝胶的制备方法
KR102592782B1 (ko) * 2017-01-23 2023-10-20 에이에프와이엑스 테라퓨틱스 에스에이 전기방사 섬유에 기반한 2층 제품의 제조 방법
KR102029926B1 (ko) * 2017-12-14 2019-10-08 금오공과대학교 산학협력단 풀루란을 이용한 하이드로젤 지혈제 및 그 제조방법
CN112055599A (zh) * 2018-02-15 2020-12-08 比奥马普法国公司 多维止血产品及其制造方法
CA3132954A1 (en) 2019-03-20 2020-09-24 Astellas Pharma Inc. Thrombin-carrying hemostatic sheet
EP3996757B1 (en) 2019-07-12 2023-04-19 GATT Technologies B.V. Biocompatible, flexible, haemostatic sheet
CN114096287B (zh) * 2019-07-12 2023-05-02 加特技术公司 用于制备组织粘附片的方法
JP7530182B2 (ja) * 2020-02-06 2024-08-07 株式会社東芝 生体適合部材
US11739166B2 (en) 2020-07-02 2023-08-29 Davol Inc. Reactive polysaccharide-based hemostatic agent
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