KR102252925B1 - 마크롤라이드 디아스테레오머를 포함하는 약제학적 조성물, 이의 합성 방법 및 치료학적 용도 - Google Patents

마크롤라이드 디아스테레오머를 포함하는 약제학적 조성물, 이의 합성 방법 및 치료학적 용도 Download PDF

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KR102252925B1
KR102252925B1 KR1020167008038A KR20167008038A KR102252925B1 KR 102252925 B1 KR102252925 B1 KR 102252925B1 KR 1020167008038 A KR1020167008038 A KR 1020167008038A KR 20167008038 A KR20167008038 A KR 20167008038A KR 102252925 B1 KR102252925 B1 KR 102252925B1
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formula
compound
diastereomer
iib
chiral carbon
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KR20160045146A (ko
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토마스 니톨리
나레시쿠마르 에프. 자인
토마스 패트릭 마르코탄
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리제너론 파마슈티칼스 인코포레이티드
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/537—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines spiro-condensed or forming part of bridged ring systems
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    • A61K31/5365—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines ortho- or peri-condensed with heterocyclic ring systems
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    • A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
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    • A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
    • A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
    • A61K47/6807—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug or compound being a sugar, nucleoside, nucleotide, nucleic acid, e.g. RNA antisense
    • A61K47/6809—Antibiotics, e.g. antitumor antibiotics anthracyclins, adriamycin, doxorubicin or daunomycin
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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/18—Bridged systems
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
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  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
KR1020167008038A 2013-08-26 2014-08-26 마크롤라이드 디아스테레오머를 포함하는 약제학적 조성물, 이의 합성 방법 및 치료학적 용도 Active KR102252925B1 (ko)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201361869954P 2013-08-26 2013-08-26
US61/869,954 2013-08-26
US201461934313P 2014-01-31 2014-01-31
US61/934,313 2014-01-31
PCT/US2014/052757 WO2015031396A1 (en) 2013-08-26 2014-08-26 Pharmaceutical compositions comprising macrolide diastereomers, methods of their synthesis and therapeutic uses

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KR20160045146A KR20160045146A (ko) 2016-04-26
KR102252925B1 true KR102252925B1 (ko) 2021-05-18

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US (3) US20160354482A1 (enExample)
EP (1) EP3038624B1 (enExample)
JP (1) JP6608823B2 (enExample)
KR (1) KR102252925B1 (enExample)
CN (1) CN105530942B (enExample)
AU (1) AU2014311361B2 (enExample)
BR (1) BR112016004023A2 (enExample)
CA (1) CA2921412C (enExample)
CL (1) CL2016000408A1 (enExample)
EA (1) EA038192B1 (enExample)
ES (1) ES2989322T3 (enExample)
IL (1) IL244203B (enExample)
MX (1) MX373528B (enExample)
PH (1) PH12016500380A1 (enExample)
SG (1) SG11201601230RA (enExample)
WO (1) WO2015031396A1 (enExample)
ZA (1) ZA201601534B (enExample)

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