KR102241962B1 - 유전적으로 변형된 비-인간 동물 및 이것들의 사용 방법 - Google Patents

유전적으로 변형된 비-인간 동물 및 이것들의 사용 방법 Download PDF

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KR102241962B1
KR102241962B1 KR1020157008697A KR20157008697A KR102241962B1 KR 102241962 B1 KR102241962 B1 KR 102241962B1 KR 1020157008697 A KR1020157008697 A KR 1020157008697A KR 20157008697 A KR20157008697 A KR 20157008697A KR 102241962 B1 KR102241962 B1 KR 102241962B1
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human
mouse
cells
polypeptide
genetically modified
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KR20150052274A (ko
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리차드 에이. 플라벨
마르쿠스 만츠
안토니 롱박스
틸 스트로위그
팀 윌링거
앤드류 제이. 머피
션 스티븐스
조지 얀코풀로스
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예일 유니버시티
인스티튜트 포 리서치 인 바이오메드슨
리제너론 파마슈티칼스 인코포레이티드
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    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • A01K67/0278—Knock-in vertebrates, e.g. humanised vertebrates
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
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    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0271—Chimeric vertebrates, e.g. comprising exogenous cells
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    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
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    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
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    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
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    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • C07K14/4705—Regulators; Modulating activity stimulating, promoting or activating activity
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    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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    • C07K14/524—Thrombopoietin, i.e. C-MPL ligand
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    • C07K14/52—Cytokines; Lymphokines; Interferons
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    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
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    • C07K14/52—Cytokines; Lymphokines; Interferons
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
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    • A01K2207/00—Modified animals
    • A01K2207/12—Animals modified by administration of exogenous cells
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    • A01K2207/00—Modified animals
    • A01K2207/15—Humanized animals
    • A—HUMAN NECESSITIES
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    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
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    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
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    • A01K2217/00—Genetically modified animals
    • A01K2217/15—Animals comprising multiple alterations of the genome, by transgenesis or homologous recombination, e.g. obtained by cross-breeding
    • A—HUMAN NECESSITIES
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KR1020157008697A 2012-09-07 2013-09-06 유전적으로 변형된 비-인간 동물 및 이것들의 사용 방법 Active KR102241962B1 (ko)

Priority Applications (1)

Application Number Priority Date Filing Date Title
KR1020217010949A KR102287541B1 (ko) 2012-09-07 2013-09-06 유전적으로 변형된 비-인간 동물 및 이것들의 사용 방법

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201261698002P 2012-09-07 2012-09-07
US61/698,002 2012-09-07
US201361775171P 2013-03-08 2013-03-08
US61/775,171 2013-03-08
PCT/US2013/058448 WO2014039782A2 (en) 2012-09-07 2013-09-06 Genetically modified non-human animals and methods of use thereof

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KR1020217010949A Division KR102287541B1 (ko) 2012-09-07 2013-09-06 유전적으로 변형된 비-인간 동물 및 이것들의 사용 방법

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KR20150052274A KR20150052274A (ko) 2015-05-13
KR102241962B1 true KR102241962B1 (ko) 2021-04-20

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KR1020157008697A Active KR102241962B1 (ko) 2012-09-07 2013-09-06 유전적으로 변형된 비-인간 동물 및 이것들의 사용 방법
KR1020227041881A Active KR102594390B1 (ko) 2012-09-07 2013-09-06 유전적으로 변형된 비-인간 동물 및 이것들의 사용 방법
KR1020237036218A Active KR102645622B1 (ko) 2012-09-07 2013-09-06 유전적으로 변형된 비-인간 동물 및 이것들의 사용 방법
KR1020217024519A Active KR102340059B1 (ko) 2012-09-07 2013-09-06 유전적으로 변형된 비-인간 동물 및 이것들의 사용 방법
KR1020217040735A Active KR102473555B1 (ko) 2012-09-07 2013-09-06 유전적으로 변형된 비-인간 동물 및 이것들의 사용 방법
KR1020247007446A Pending KR20240045263A (ko) 2012-09-07 2013-09-06 유전적으로 변형된 비-인간 동물 및 이것들의 사용 방법
KR1020217010949A Active KR102287541B1 (ko) 2012-09-07 2013-09-06 유전적으로 변형된 비-인간 동물 및 이것들의 사용 방법

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KR1020227041881A Active KR102594390B1 (ko) 2012-09-07 2013-09-06 유전적으로 변형된 비-인간 동물 및 이것들의 사용 방법
KR1020237036218A Active KR102645622B1 (ko) 2012-09-07 2013-09-06 유전적으로 변형된 비-인간 동물 및 이것들의 사용 방법
KR1020217024519A Active KR102340059B1 (ko) 2012-09-07 2013-09-06 유전적으로 변형된 비-인간 동물 및 이것들의 사용 방법
KR1020217040735A Active KR102473555B1 (ko) 2012-09-07 2013-09-06 유전적으로 변형된 비-인간 동물 및 이것들의 사용 방법
KR1020247007446A Pending KR20240045263A (ko) 2012-09-07 2013-09-06 유전적으로 변형된 비-인간 동물 및 이것들의 사용 방법
KR1020217010949A Active KR102287541B1 (ko) 2012-09-07 2013-09-06 유전적으로 변형된 비-인간 동물 및 이것들의 사용 방법

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US (6) US9820476B2 (https=)
EP (3) EP4193834B1 (https=)
JP (5) JP6283031B2 (https=)
KR (7) KR102241962B1 (https=)
CN (4) CN108782459B (https=)
AU (3) AU2013312359B8 (https=)
CA (1) CA2881468C (https=)
DK (1) DK2892330T3 (https=)
ES (2) ES2938342T3 (https=)
FI (1) FI2892330T3 (https=)
IL (4) IL282472B2 (https=)
IN (1) IN2015DN02032A (https=)
MX (2) MX385035B (https=)
NZ (3) NZ746089A (https=)
PT (1) PT2892330T (https=)
RU (2) RU2768282C2 (https=)
SG (2) SG11201500504RA (https=)
WO (1) WO2014039782A2 (https=)

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SG10202008003VA (en) * 2011-02-15 2020-10-29 Regeneron Pharma Humanized m-csf mice
FI2892330T3 (fi) * 2012-09-07 2023-03-25 Univ Yale Geneettisesti muokattuja hiiriä ja menetelmiä niiden käyttämiseksi
MX377561B (es) * 2012-11-05 2025-03-10 Regeneron Pharma Animales no humanos genéticamente modificados y métodos de uso de los mismos.
TR201901782T4 (tr) 2013-09-23 2019-03-21 Regeneron Pharma İnsanlaştirilmiş bi̇r si̇nyal düzenleyi̇ci̇ protei̇n geni̇ne sahi̇p olan i̇nsan dişi hayvanlar.
ES2613379T3 (es) 2013-10-15 2017-05-24 Regeneron Pharmaceuticals, Inc. Animales con IL-15 humanizada
RU2671101C1 (ru) 2013-11-19 2018-10-29 Регенерон Фармасьютикалс, Инк. Отличные от человека животные, содержащие гуманизированный ген индуцирующего пролиферацию лиганда
EP3636073B1 (en) 2014-05-05 2023-11-15 Regeneron Pharmaceuticals, Inc. Humanized c5 and c3 animals
NO2785538T3 (https=) 2014-05-07 2018-08-04
MX2016014995A (es) 2014-05-19 2017-03-31 Regeneron Pharma Animales no humanos geneticamente modificados que expresan eritropoyetina de humano.
HUE064960T2 (hu) 2014-12-05 2024-04-28 Regeneron Pharma Differenciációs 47 gén humanizált klasztert tartalmazó nem-humán állatok
CN113412818B (zh) 2014-12-09 2022-11-04 瑞泽恩制药公司 具有人源化分化簇274基因的非人动物
CN116059378A (zh) 2014-12-10 2023-05-05 明尼苏达大学董事会 用于治疗疾病的遗传修饰的细胞、组织和器官
ES2950399T3 (es) 2015-04-13 2023-10-09 Regeneron Pharma Ratones humanizados Sirpa-IL15 insertados y métodos de uso de los mismos
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