KR102233325B1 - 골 대체 물질 - Google Patents

골 대체 물질 Download PDF

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Publication number
KR102233325B1
KR102233325B1 KR1020207016840A KR20207016840A KR102233325B1 KR 102233325 B1 KR102233325 B1 KR 102233325B1 KR 1020207016840 A KR1020207016840 A KR 1020207016840A KR 20207016840 A KR20207016840 A KR 20207016840A KR 102233325 B1 KR102233325 B1 KR 102233325B1
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South Korea
Prior art keywords
hap
cap
hydroxyapatite
bone substitute
epitaxy
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KR1020207016840A
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English (en)
Korean (ko)
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KR20200076753A (ko
Inventor
클라우디오 칠만
미하엘 부플러
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가이스틀리히 파마 아게
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/02Inorganic materials
    • A61L27/12Phosphorus-containing materials, e.g. apatite
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/28Bones
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/0047Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
    • A61L24/0052Composite materials, i.e. containing one material dispersed in a matrix of the same or different material with an inorganic matrix
    • A61L24/0063Phosphorus containing materials, e.g. apatite
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/28Materials for coating prostheses
    • A61L27/30Inorganic materials
    • A61L27/32Phosphorus-containing materials, e.g. apatite
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/40Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
    • A61L27/42Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having an inorganic matrix
    • A61L27/425Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having an inorganic matrix of phosphorus containing material, e.g. apatite
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/40Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
    • A61L27/44Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
    • A61L27/46Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix with phosphorus-containing inorganic fillers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/56Porous materials, e.g. foams or sponges
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/58Materials at least partially resorbable by the body
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/28Bones
    • A61F2002/2835Bone graft implants for filling a bony defect or an endoprosthesis cavity, e.g. by synthetic material or biological material
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2310/00Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
    • A61F2310/00005The prosthesis being constructed from a particular material
    • A61F2310/00179Ceramics or ceramic-like structures
    • A61F2310/00293Ceramics or ceramic-like structures containing a phosphorus-containing compound, e.g. apatite
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2400/00Materials characterised by their function or physical properties
    • A61L2400/12Nanosized materials, e.g. nanofibres, nanoparticles, nanowires, nanotubes; Nanostructured surfaces
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2400/00Materials characterised by their function or physical properties
    • A61L2400/18Modification of implant surfaces in order to improve biocompatibility, cell growth, fixation of biomolecules, e.g. plasma treatment
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00Materials or treatment for tissue regeneration
    • A61L2430/02Materials or treatment for tissue regeneration for reconstruction of bones; weight-bearing implants
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B33ADDITIVE MANUFACTURING TECHNOLOGY
    • B33YADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3-D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3-D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING
    • B33Y80/00Products made by additive manufacturing

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Dermatology (AREA)
  • Medicinal Chemistry (AREA)
  • Inorganic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Materials Engineering (AREA)
  • Composite Materials (AREA)
  • Dispersion Chemistry (AREA)
  • Surgery (AREA)
  • Cardiology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Manufacturing & Machinery (AREA)
  • Materials For Medical Uses (AREA)
  • Prostheses (AREA)
KR1020207016840A 2017-12-14 2018-12-13 골 대체 물질 Active KR102233325B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP17207235 2017-12-14
EP17207235.7 2017-12-14
PCT/EP2018/084783 WO2019115704A1 (en) 2017-12-14 2018-12-13 Bone substitute material

Publications (2)

Publication Number Publication Date
KR20200076753A KR20200076753A (ko) 2020-06-29
KR102233325B1 true KR102233325B1 (ko) 2021-03-29

Family

ID=60781527

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020207016840A Active KR102233325B1 (ko) 2017-12-14 2018-12-13 골 대체 물질

Country Status (18)

Country Link
US (2) US11351287B2 (enExample)
EP (1) EP3544643B1 (enExample)
JP (2) JP6880330B2 (enExample)
KR (1) KR102233325B1 (enExample)
CN (1) CN111465418B (enExample)
AU (1) AU2018382557B2 (enExample)
BR (1) BR112020010213B1 (enExample)
CA (1) CA3083852A1 (enExample)
DK (1) DK3544643T3 (enExample)
ES (1) ES2803976T3 (enExample)
HU (1) HUE050062T2 (enExample)
IL (1) IL275203B2 (enExample)
MX (1) MX2020005846A (enExample)
PL (1) PL3544643T3 (enExample)
PT (1) PT3544643T (enExample)
SG (1) SG11202004726YA (enExample)
TW (1) TWI852918B (enExample)
WO (1) WO2019115704A1 (enExample)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT3544643T (pt) 2017-12-14 2020-07-27 Geistlich Pharma Ag Material de substituição óssea
KR102636183B1 (ko) 2019-06-14 2024-02-13 가이스틀리히 파마 아게 골 대체 물질의 콜라겐 기질 또는 그래뉼레이트 블렌드
DE202021004032U1 (de) 2020-08-29 2022-10-10 BioScientific Designs d.o.o Ein steriles Medizinprodukt als Knochenersatz, Zubereitung und Verwendung

Citations (5)

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US20030026770A1 (en) 2001-07-25 2003-02-06 Szymaitis Dennis W. Periodontal regeneration composition and method of using same
US20120130506A1 (en) * 2009-06-23 2012-05-24 Geistlich Pharma Ag Bone substitute material
US20140127392A1 (en) * 2006-10-24 2014-05-08 Biomet 3I, Llc Deposition of discrete nanoparticles on a nanostructured surface of an implant
US20150024023A1 (en) 2011-12-23 2015-01-22 The University Court Of The University Of Aberdeen Calcium phosphate material
US20160106674A1 (en) 2013-05-15 2016-04-21 Euroresearch S.R.L. Collagen powder, composition and use

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JPS60220056A (ja) * 1984-04-18 1985-11-02 三菱マテリアル株式会社 人工歯
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GB8813033D0 (en) 1988-06-02 1988-07-06 Geistlich Soehne Ag Chemical compound
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US5763092A (en) 1993-09-15 1998-06-09 Etex Corporation Hydroxyapatite coatings and a method of their manufacture
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US6338752B1 (en) 2000-04-20 2002-01-15 Purzer Pharmaceutical Co., Ltd. α-TCP/HAP biphasic cement and its preparing process
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CN1974876B (zh) * 2006-11-02 2010-07-07 华南理工大学 钛金属表面生物活性膜层及其喷砂-微弧氧化复合工艺
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CN101850131A (zh) * 2010-04-30 2010-10-06 武汉理工大学 晶核引导骨性结合的金属植入体表面改性的方法
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EP2654816B1 (en) 2010-12-22 2015-02-11 Geistlich Pharma AG Bone substitute material
DE102011050183A1 (de) * 2011-05-06 2012-11-08 Aesculap Ag Oberflächenprofilierter Gitterkörper
NL2011195C2 (en) 2013-07-18 2015-01-21 Xpand Biotechnology B V Method for producing an osteoinductive calcium phosphate and products thus obtained.
EP2826495A1 (en) 2013-07-19 2015-01-21 Geistlich Pharma AG Biomimetic collagen-hydroxyapatite composite material
TWI783093B (zh) 2017-12-14 2022-11-11 瑞士商蓋茲特利製藥公司 骨替代材料及其製備及應用
CN111511415B (zh) 2017-12-14 2021-04-20 盖斯特里希医药公司 干式植入物组合物和可注射的水性植入物制剂
PT3544643T (pt) 2017-12-14 2020-07-27 Geistlich Pharma Ag Material de substituição óssea

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030026770A1 (en) 2001-07-25 2003-02-06 Szymaitis Dennis W. Periodontal regeneration composition and method of using same
US20140127392A1 (en) * 2006-10-24 2014-05-08 Biomet 3I, Llc Deposition of discrete nanoparticles on a nanostructured surface of an implant
US20120130506A1 (en) * 2009-06-23 2012-05-24 Geistlich Pharma Ag Bone substitute material
US20150024023A1 (en) 2011-12-23 2015-01-22 The University Court Of The University Of Aberdeen Calcium phosphate material
US20160106674A1 (en) 2013-05-15 2016-04-21 Euroresearch S.R.L. Collagen powder, composition and use

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* Cited by examiner, † Cited by third party
Title
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Also Published As

Publication number Publication date
AU2018382557A1 (en) 2020-06-11
CA3083852A1 (en) 2019-06-20
CN111465418A (zh) 2020-07-28
BR112020010213A2 (pt) 2020-08-18
WO2019115704A1 (en) 2019-06-20
ES2803976T3 (es) 2021-02-01
CN111465418B (zh) 2021-07-09
US20200016293A1 (en) 2020-01-16
PT3544643T (pt) 2020-07-27
US20190184059A1 (en) 2019-06-20
JP2021506401A (ja) 2021-02-22
HUE050062T2 (hu) 2020-11-30
RU2020118930A (ru) 2022-01-14
SG11202004726YA (en) 2020-07-29
TW201936216A (zh) 2019-09-16
DK3544643T3 (da) 2020-07-06
IL275203B (en) 2022-11-01
IL275203A (en) 2020-07-30
JP7249376B2 (ja) 2023-03-30
US10646615B2 (en) 2020-05-12
JP6880330B2 (ja) 2021-06-02
EP3544643B1 (en) 2020-05-13
PL3544643T3 (pl) 2020-12-28
TWI852918B (zh) 2024-08-21
US11351287B2 (en) 2022-06-07
JP2021118906A (ja) 2021-08-12
IL275203B2 (en) 2023-03-01
MX2020005846A (es) 2020-09-07
BR112020010213B1 (pt) 2020-12-22
RU2020118930A3 (enExample) 2022-02-25
AU2018382557B2 (en) 2024-05-02
EP3544643A1 (en) 2019-10-02
KR20200076753A (ko) 2020-06-29

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