KR102137717B1 - 채널로돕신-2 (chop2) 돌연변이의 확인 및 사용 방법 - Google Patents

채널로돕신-2 (chop2) 돌연변이의 확인 및 사용 방법 Download PDF

Info

Publication number
KR102137717B1
KR102137717B1 KR1020147027985A KR20147027985A KR102137717B1 KR 102137717 B1 KR102137717 B1 KR 102137717B1 KR 1020147027985 A KR1020147027985 A KR 1020147027985A KR 20147027985 A KR20147027985 A KR 20147027985A KR 102137717 B1 KR102137717 B1 KR 102137717B1
Authority
KR
South Korea
Prior art keywords
gly
leu
val
ala
thr
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
KR1020147027985A
Other languages
English (en)
Korean (ko)
Other versions
KR20140132401A (ko
Inventor
주오-화 팬
Original Assignee
웨인 스테이트 유니버시티
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 웨인 스테이트 유니버시티 filed Critical 웨인 스테이트 유니버시티
Publication of KR20140132401A publication Critical patent/KR20140132401A/ko
Application granted granted Critical
Publication of KR102137717B1 publication Critical patent/KR102137717B1/ko
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/405—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from algae
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Biotechnology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Ophthalmology & Optometry (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
KR1020147027985A 2012-03-05 2013-03-05 채널로돕신-2 (chop2) 돌연변이의 확인 및 사용 방법 Active KR102137717B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261606663P 2012-03-05 2012-03-05
US61/606,663 2012-03-05
PCT/US2013/029171 WO2013134295A1 (en) 2012-03-05 2013-03-05 Identification of channelrhodopsin-2 (chop2) mutations and methods of use

Publications (2)

Publication Number Publication Date
KR20140132401A KR20140132401A (ko) 2014-11-17
KR102137717B1 true KR102137717B1 (ko) 2020-07-27

Family

ID=47892055

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020147027985A Active KR102137717B1 (ko) 2012-03-05 2013-03-05 채널로돕신-2 (chop2) 돌연변이의 확인 및 사용 방법

Country Status (16)

Country Link
US (3) US10947281B2 (enExample)
EP (1) EP2822964B1 (enExample)
JP (3) JP6395611B2 (enExample)
KR (1) KR102137717B1 (enExample)
CN (2) CN104334575A (enExample)
AU (4) AU2013230112A1 (enExample)
CA (1) CA2866405A1 (enExample)
DK (1) DK2822964T3 (enExample)
EA (1) EA201491643A1 (enExample)
ES (1) ES2703324T3 (enExample)
HU (1) HUE040487T2 (enExample)
MX (1) MX360085B (enExample)
NZ (1) NZ629843A (enExample)
PL (1) PL2822964T3 (enExample)
PT (1) PT2822964T (enExample)
WO (1) WO2013134295A1 (enExample)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2685900A1 (en) 2006-05-04 2007-11-15 Wayne State University Restoration of visual responses by in vivo delivery of rhodopsin nucleic acids
US9453241B2 (en) 2010-05-04 2016-09-27 Wayne State University AAV-mediated subcellular targeting of heterologous rhodopsins in retinal ganglion cells
DK2822964T3 (en) 2012-03-05 2018-12-10 Univ Wayne State IDENTIFICATION OF CHANNEL RHODOPSIN-2- (CHOP2) MUTATIONS AND METHODS OF USE
EP2968476B1 (en) 2013-03-14 2021-05-05 Wayne State University A plasmin for use in enhancing delivery of therapeutic compounds to the eyes or for improving vision
WO2015004565A1 (en) 2013-07-08 2015-01-15 Basf Se Oxime ester photoinitiators
CA3234028A1 (en) 2014-03-11 2015-09-17 Wayne State University A modified mglur6 promoter and methods of use
MX2018013352A (es) 2016-05-03 2019-08-01 Univ Wayne State Metodo para mejorar suministro de genes mediado por virus en el ojo usando inhibidores de proteosoma.
KR20190020702A (ko) * 2016-06-03 2019-03-04 막스-플랑크-게젤샤프트 츄어 푀르더룽 데어 비쎈샤프텐 에.파우. 채널로돕신의 돌연변이 광-유도성 이온 채널
KR102877327B1 (ko) * 2016-08-29 2025-10-27 웨인 스테이트 유니버시티 개선된 광 민감성을 갖는 채널옵신 변이체에서의 돌연변이의 확인 및 이의 용도
US11180537B2 (en) * 2016-11-06 2021-11-23 Nancoscope Technologies LLC Optogenetic modulation by Multi-Characteristic Opsins for vision restoration and other applications
WO2018189247A1 (en) * 2017-04-12 2018-10-18 MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. New optogenetic tool
PT3720428T (pt) * 2017-12-04 2023-04-03 Salvat Lab Sa Composição tópica oftálmica compreendendo ácido dobesílico para tratamento de doenças do segmento posterior do olho
JP6567153B1 (ja) * 2018-09-28 2019-08-28 学校法人東北工業大学 対象化合物の特性の予測を行うための方法、コンピュータシステム、プログラム
WO2024226667A2 (en) * 2023-04-24 2024-10-31 Nanoscope Therapeutics Inc. Optogenetic modulation by multi-characteristic opsins for vision restoration and other applications thereof

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101639859B1 (ko) 2014-03-06 2016-07-14 포항공과대학교 산학협력단 광 자극에 의한 미토콘드리아 활성의 시공간적 가역 조절 방법

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4554101A (en) 1981-01-09 1985-11-19 New York Blood Center, Inc. Identification and preparation of epitopes on antigens and allergens on the basis of hydrophilicity
US4498919A (en) 1983-10-31 1985-02-12 Corning Glass Works Method for making colored photochromic prescription ophthalmic lenses
US6610287B1 (en) 1990-04-16 2003-08-26 The General Hospital Corporation Transfer and expression of gene sequences into nervous system cells using herpes simplex virus mutants with deletions in genes for viral replication
US5827702A (en) 1994-10-31 1998-10-27 Genentech, Inc. Ocular gene therapy
AU7467598A (en) 1997-04-21 1998-11-13 University Of Florida Materials and methods for treatment of retinal diseases
NZ511037A (en) 1998-09-17 2005-02-25 Univ Florida Methods for treatment of degenerative retinal diseases
WO2001083692A2 (en) 2000-04-28 2001-11-08 The Trustees Of The University Of Pennsylvania Recombinant aav vectors with aav5 capsids and aav5 vectors pseudotyped in heterologous capsids
CA2442670A1 (en) 2001-04-13 2002-10-24 The Trustees Of The University Of Pennsylvania Method of treating or retarding the development of blindness
WO2003016486A2 (en) 2001-08-16 2003-02-27 Sloan Kettering Institute For Cancer Research Bio-synthetic photostimulators and methods of use
DE10216005A1 (de) 2002-04-11 2003-10-30 Max Planck Gesellschaft Verwendung von biologischen Photorezeptoren als direkt lichtgesteuerte Ionenkanäle
WO2004009022A2 (en) 2002-07-18 2004-01-29 The General Hospital Corp. Method for augmenting vision in persons suffering from photoreceptor cell degeneration
US7186699B2 (en) 2003-06-03 2007-03-06 Cell Genesys, Inc. Method for treating cancer by vector-mediated delivery of one or more anti-angiogenic or pro-apoptotic genes
US7427138B2 (en) 2003-11-05 2008-09-23 Neurovision, Inc. Method and apparatus for improving visual perception
EP2465925A1 (en) 2005-07-22 2012-06-20 The Board Of Trustees Of The Leland Light-activated cation channel and uses thereof
CA2685900A1 (en) 2006-05-04 2007-11-15 Wayne State University Restoration of visual responses by in vivo delivery of rhodopsin nucleic acids
US9453241B2 (en) 2010-05-04 2016-09-27 Wayne State University AAV-mediated subcellular targeting of heterologous rhodopsins in retinal ganglion cells
US8748578B2 (en) * 2010-09-08 2014-06-10 Max-Planck-Gesellschaft zur Foerderrung der Wissenschaften e.V. Mutant channelrhodopsin 2
DK2822964T3 (en) * 2012-03-05 2018-12-10 Univ Wayne State IDENTIFICATION OF CHANNEL RHODOPSIN-2- (CHOP2) MUTATIONS AND METHODS OF USE

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101639859B1 (ko) 2014-03-06 2016-07-14 포항공과대학교 산학협력단 광 자극에 의한 미토콘드리아 활성의 시공간적 가역 조절 방법

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
Mol. Genet. Genomics, Vol.287:95-109 (Published online 2011. 12. 20.)*
NATURE NEUROSCIENCE, Vol.14(4):513-518 (2011. 3.)*

Also Published As

Publication number Publication date
DK2822964T3 (en) 2018-12-10
AU2021245195A1 (en) 2021-11-04
PL2822964T3 (pl) 2019-05-31
HK1205744A1 (en) 2015-12-24
MX2014010664A (es) 2015-03-06
JP6395611B2 (ja) 2018-09-26
US20220033449A1 (en) 2022-02-03
CA2866405A1 (en) 2013-09-12
PT2822964T (pt) 2018-11-29
US10947281B2 (en) 2021-03-16
MX360085B (es) 2018-10-10
ES2703324T3 (es) 2019-03-08
WO2013134295A1 (en) 2013-09-12
CN111378020A (zh) 2020-07-07
JP2019193656A (ja) 2019-11-07
AU2021245195B2 (en) 2023-09-28
NZ727041A (en) 2022-01-28
KR20140132401A (ko) 2014-11-17
AU2017239601B2 (en) 2019-05-16
EA201491643A1 (ru) 2015-02-27
HUE040487T2 (hu) 2019-03-28
EP2822964A1 (en) 2015-01-14
US20250066431A1 (en) 2025-02-27
AU2017239601A1 (en) 2017-10-26
US20150044181A1 (en) 2015-02-12
EP2822964B1 (en) 2018-08-22
AU2019216638A1 (en) 2019-09-05
CN104334575A (zh) 2015-02-04
JP2018134098A (ja) 2018-08-30
JP2015510759A (ja) 2015-04-13
AU2019216638B2 (en) 2021-07-08
NZ629843A (en) 2017-03-31
AU2013230112A1 (en) 2014-09-25

Similar Documents

Publication Publication Date Title
AU2021245195B2 (en) Identification of Channelopsin-2 (Chop2) mutations and methods of use
KR102008538B1 (ko) 감광성 키메라 gpcr 단백질
JP2018076377A (ja) ロドプシン拡散のインビボ送達による視覚応答の回復
WO2014179331A2 (en) Devices, systems and methods for optogenetic modulation of action potentials in target cells
JP6942789B2 (ja) Ｃｈｒｉｍｓｏｎを用いた光遺伝学的視覚回復
US20230159609A1 (en) G-protein-gated-k+ channel-mediated enhancements in light sensitivity in rod-cone dystrophy (rcd)
JP6779546B2 (ja) 視力回復のための多特性オプシンによる光遺伝学的調節及びその別の用途
EP3892738A1 (en) G-protein-gated-k+ channel-mediated enhancements in light sensitivity in rod-cone dystrophy (rcd)
EA043449B1 (ru) ИДЕНТИФИКАЦИЯ МУТАЦИЙ КАНАЛ-ОПСИНА-2 (Chop2) И СПОСОБЫ ПРИМЕНЕНИЯ
HK1205744B (en) Identification of channelrhodopsin-2 (chop2) mutations and methods of use
US20230338581A1 (en) G-protein-gated-k+ channel-mediated enhancements in light sensitivity in rod-cone dystrophy (rcd)
NZ727041B2 (en) Identification of channelrhodopsin-2 (chop2) mutations and methods of use
Tochitsky Photochemical control of neuronal activity: methods and clinical application
Munckton Design and use of a light-gated potassium channel

Legal Events

Date Code Title Description
PA0105 International application

Patent event date: 20141002

Patent event code: PA01051R01D

Comment text: International Patent Application

PG1501 Laying open of application
A201 Request for examination
AMND Amendment
PA0201 Request for examination

Patent event code: PA02012R01D

Patent event date: 20180305

Comment text: Request for Examination of Application

E902 Notification of reason for refusal
PE0902 Notice of grounds for rejection

Comment text: Notification of reason for refusal

Patent event date: 20190717

Patent event code: PE09021S01D

AMND Amendment
E601 Decision to refuse application
PE0601 Decision on rejection of patent

Patent event date: 20200228

Comment text: Decision to Refuse Application

Patent event code: PE06012S01D

Patent event date: 20190717

Comment text: Notification of reason for refusal

Patent event code: PE06011S01I

AMND Amendment
PX0901 Re-examination

Patent event code: PX09011S01I

Patent event date: 20200228

Comment text: Decision to Refuse Application

Patent event code: PX09012R01I

Patent event date: 20191001

Comment text: Amendment to Specification, etc.

Patent event code: PX09012R01I

Patent event date: 20180305

Comment text: Amendment to Specification, etc.

PX0701 Decision of registration after re-examination

Patent event date: 20200417

Comment text: Decision to Grant Registration

Patent event code: PX07013S01D

Patent event date: 20200327

Comment text: Amendment to Specification, etc.

Patent event code: PX07012R01I

Patent event date: 20200228

Comment text: Decision to Refuse Application

Patent event code: PX07011S01I

Patent event date: 20191001

Comment text: Amendment to Specification, etc.

Patent event code: PX07012R01I

Patent event date: 20180305

Comment text: Amendment to Specification, etc.

Patent event code: PX07012R01I

X701 Decision to grant (after re-examination)
GRNT Written decision to grant
PA0104 Divisional application for international application

Comment text: Divisional Application for International Patent

Patent event code: PA01041R01D

Patent event date: 20200720

PR0701 Registration of establishment

Comment text: Registration of Establishment

Patent event date: 20200720

Patent event code: PR07011E01D

PR1002 Payment of registration fee

Payment date: 20200721

End annual number: 3

Start annual number: 1

PG1601 Publication of registration
PR1001 Payment of annual fee

Payment date: 20240619

Start annual number: 5

End annual number: 5

PR1001 Payment of annual fee

Payment date: 20250616

Start annual number: 6

End annual number: 6