KR102131588B1 - 간세포 암종 (hcc) 의 치료를 위해 사용되는 6-옥소-1,6-디히드로-피리다진 유도체 - Google Patents
간세포 암종 (hcc) 의 치료를 위해 사용되는 6-옥소-1,6-디히드로-피리다진 유도체 Download PDFInfo
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- KR102131588B1 KR102131588B1 KR1020157014482A KR20157014482A KR102131588B1 KR 102131588 B1 KR102131588 B1 KR 102131588B1 KR 1020157014482 A KR1020157014482 A KR 1020157014482A KR 20157014482 A KR20157014482 A KR 20157014482A KR 102131588 B1 KR102131588 B1 KR 102131588B1
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- oxo
- dihydro
- methyl
- benzyl
- ylmethoxy
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- 229940049953 phenylacetate Drugs 0.000 description 1
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- 150000003904 phospholipids Chemical class 0.000 description 1
- XNGIFLGASWRNHJ-UHFFFAOYSA-L phthalate(2-) Chemical compound [O-]C(=O)C1=CC=CC=C1C([O-])=O XNGIFLGASWRNHJ-UHFFFAOYSA-L 0.000 description 1
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- 229950010765 pivalate Drugs 0.000 description 1
- IUGYQRQAERSCNH-UHFFFAOYSA-N pivalic acid Chemical compound CC(C)(C)C(O)=O IUGYQRQAERSCNH-UHFFFAOYSA-N 0.000 description 1
- 239000011505 plaster Substances 0.000 description 1
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- 239000004626 polylactic acid Substances 0.000 description 1
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- 239000002861 polymer material Substances 0.000 description 1
- 229920006324 polyoxymethylene Polymers 0.000 description 1
- 230000008092 positive effect Effects 0.000 description 1
- RPDAUEIUDPHABB-UHFFFAOYSA-N potassium ethoxide Chemical compound [K+].CC[O-] RPDAUEIUDPHABB-UHFFFAOYSA-N 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
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- 235000013874 shellac Nutrition 0.000 description 1
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- AWUCVROLDVIAJX-GSVOUGTGSA-N sn-glycerol 3-phosphate Chemical compound OC[C@@H](O)COP(O)(O)=O AWUCVROLDVIAJX-GSVOUGTGSA-N 0.000 description 1
- 239000001632 sodium acetate Substances 0.000 description 1
- 235000017281 sodium acetate Nutrition 0.000 description 1
- 235000010413 sodium alginate Nutrition 0.000 description 1
- 239000000661 sodium alginate Substances 0.000 description 1
- 229940005550 sodium alginate Drugs 0.000 description 1
- WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 description 1
- 235000010234 sodium benzoate Nutrition 0.000 description 1
- 239000004299 sodium benzoate Substances 0.000 description 1
- 229910000029 sodium carbonate Inorganic materials 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- RYYKJJJTJZKILX-UHFFFAOYSA-M sodium octadecanoate Chemical compound [Na+].CCCCCCCCCCCCCCCCCC([O-])=O RYYKJJJTJZKILX-UHFFFAOYSA-M 0.000 description 1
- 239000001488 sodium phosphate Substances 0.000 description 1
- 229910000162 sodium phosphate Inorganic materials 0.000 description 1
- RCOSUMRTSQULBK-UHFFFAOYSA-N sodium;propan-1-olate Chemical compound [Na+].CCC[O-] RCOSUMRTSQULBK-UHFFFAOYSA-N 0.000 description 1
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- 235000020679 tap water Nutrition 0.000 description 1
- NBRKLOOSMBRFMH-UHFFFAOYSA-N tert-butyl chloride Chemical compound CC(C)(C)Cl NBRKLOOSMBRFMH-UHFFFAOYSA-N 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 229960004559 theobromine Drugs 0.000 description 1
- 239000002562 thickening agent Substances 0.000 description 1
- JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 description 1
- 238000011200 topical administration Methods 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
- 235000010487 tragacanth Nutrition 0.000 description 1
- 239000000196 tragacanth Substances 0.000 description 1
- 229940116362 tragacanth Drugs 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- YFTHZRPMJXBUME-UHFFFAOYSA-N tripropylamine Chemical compound CCCN(CCC)CCC YFTHZRPMJXBUME-UHFFFAOYSA-N 0.000 description 1
- RYFMWSXOAZQYPI-UHFFFAOYSA-K trisodium phosphate Chemical compound [Na+].[Na+].[Na+].[O-]P([O-])([O-])=O RYFMWSXOAZQYPI-UHFFFAOYSA-K 0.000 description 1
- UOCLRXFKRLRMKV-UHFFFAOYSA-N trolnitrate phosphate Chemical class OP(O)(O)=O.OP(O)(O)=O.[O-][N+](=O)OCCN(CCO[N+]([O-])=O)CCO[N+]([O-])=O UOCLRXFKRLRMKV-UHFFFAOYSA-N 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Gastroenterology & Hepatology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Dispersion Chemistry (AREA)
- Dermatology (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP12007494.3 | 2012-11-02 | ||
| EP12007494 | 2012-11-02 | ||
| PCT/EP2013/002998 WO2014067610A1 (en) | 2012-11-02 | 2013-10-04 | A 6-oxo-1,6-dihydro-pyridazine derivative for the use for the treatment of hepatocellular carcinoma (hcc) |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| KR20150079942A KR20150079942A (ko) | 2015-07-08 |
| KR102131588B1 true KR102131588B1 (ko) | 2020-07-08 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020157014482A Active KR102131588B1 (ko) | 2012-11-02 | 2013-10-04 | 간세포 암종 (hcc) 의 치료를 위해 사용되는 6-옥소-1,6-디히드로-피리다진 유도체 |
Country Status (26)
| Country | Link |
|---|---|
| US (1) | US20150283137A1 (enExample) |
| EP (1) | EP2914264B1 (enExample) |
| JP (1) | JP6255028B2 (enExample) |
| KR (1) | KR102131588B1 (enExample) |
| CN (1) | CN104768553A (enExample) |
| AR (1) | AR093318A1 (enExample) |
| AU (1) | AU2013339823B2 (enExample) |
| BR (1) | BR112015008279A2 (enExample) |
| CA (1) | CA2890273C (enExample) |
| DK (1) | DK2914264T3 (enExample) |
| ES (1) | ES2646913T3 (enExample) |
| HK (1) | HK1211869A1 (enExample) |
| HR (1) | HRP20171295T1 (enExample) |
| HU (1) | HUE035483T2 (enExample) |
| IL (1) | IL238536B (enExample) |
| LT (1) | LT2914264T (enExample) |
| MX (1) | MX354518B (enExample) |
| NO (1) | NO2914264T3 (enExample) |
| PL (1) | PL2914264T3 (enExample) |
| PT (1) | PT2914264T (enExample) |
| RS (1) | RS56485B1 (enExample) |
| RU (1) | RU2650679C2 (enExample) |
| SG (1) | SG11201503214YA (enExample) |
| SI (1) | SI2914264T1 (enExample) |
| WO (1) | WO2014067610A1 (enExample) |
| ZA (1) | ZA201503924B (enExample) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2921310C (en) | 2013-08-14 | 2021-04-20 | Yugenkaisha Japan Tsusyo | Hydroponic cultivation system, and plant factory comprising hydroponic cultivation system and expanded polystyrene foam greenhouse |
| LT3996688T (lt) * | 2019-07-10 | 2023-12-27 | Merck Patent Gmbh | Farmacinis preparatas |
| JP2022551672A (ja) * | 2019-10-14 | 2022-12-12 | オラテック セラピューティクス リミティド ライアビリティ カンパニー | 乳癌治療法 |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2009007074A1 (de) * | 2007-07-12 | 2009-01-15 | Merck Patent Gmbh | Pyrimidinyl-pyridazinonderivate |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102005057924A1 (de) * | 2005-12-05 | 2007-06-06 | Merck Patent Gmbh | Pyridazinonderivate |
| KR101829595B1 (ko) * | 2009-01-08 | 2018-02-14 | 메르크 파텐트 게엠베하 | 3-（1-｛3-［5-（1-메틸-피페리딘-4일메톡시）-피리미딘-2-일］-벤질｝-6-옥소-1,6-디히드로-피리다진-3-일）-벤조니트릴 히드로클로라이드 염의 신규한 다형체 및 이의 제조 방법 |
-
2013
- 2013-10-04 RU RU2015120692A patent/RU2650679C2/ru active
- 2013-10-04 AU AU2013339823A patent/AU2013339823B2/en active Active
- 2013-10-04 CN CN201380057293.0A patent/CN104768553A/zh active Pending
- 2013-10-04 KR KR1020157014482A patent/KR102131588B1/ko active Active
- 2013-10-04 DK DK13776720.8T patent/DK2914264T3/en active
- 2013-10-04 ES ES13776720.8T patent/ES2646913T3/es active Active
- 2013-10-04 PT PT137767208T patent/PT2914264T/pt unknown
- 2013-10-04 SG SG11201503214YA patent/SG11201503214YA/en unknown
- 2013-10-04 BR BR112015008279A patent/BR112015008279A2/pt not_active Application Discontinuation
- 2013-10-04 EP EP13776720.8A patent/EP2914264B1/en active Active
- 2013-10-04 RS RS20171129A patent/RS56485B1/sr unknown
- 2013-10-04 NO NO13776720A patent/NO2914264T3/no unknown
- 2013-10-04 LT LTEP13776720.8T patent/LT2914264T/lt unknown
- 2013-10-04 JP JP2015541023A patent/JP6255028B2/ja active Active
- 2013-10-04 WO PCT/EP2013/002998 patent/WO2014067610A1/en not_active Ceased
- 2013-10-04 HU HUE13776720A patent/HUE035483T2/hu unknown
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Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2009007074A1 (de) * | 2007-07-12 | 2009-01-15 | Merck Patent Gmbh | Pyrimidinyl-pyridazinonderivate |
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| EP2914264A1 (en) | 2015-09-09 |
| MX2015005265A (es) | 2015-07-17 |
| HRP20171295T1 (hr) | 2017-10-20 |
| HK1211869A1 (en) | 2016-06-03 |
| CA2890273C (en) | 2021-10-26 |
| PT2914264T (pt) | 2017-11-14 |
| HUE035483T2 (hu) | 2018-05-02 |
| CA2890273A1 (en) | 2014-05-08 |
| SG11201503214YA (en) | 2015-05-28 |
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| AU2013339823A1 (en) | 2015-06-18 |
| IL238536A0 (en) | 2015-06-30 |
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| WO2014067610A1 (en) | 2014-05-08 |
| JP2015536957A (ja) | 2015-12-24 |
| BR112015008279A2 (pt) | 2017-07-04 |
| RU2650679C2 (ru) | 2018-04-17 |
| CN104768553A (zh) | 2015-07-08 |
| AU2013339823B2 (en) | 2018-01-04 |
| EP2914264B1 (en) | 2017-08-09 |
| PL2914264T3 (pl) | 2017-12-29 |
| KR20150079942A (ko) | 2015-07-08 |
| SI2914264T1 (sl) | 2017-12-29 |
| ES2646913T3 (es) | 2017-12-18 |
| MX354518B (es) | 2018-03-08 |
| AR093318A1 (es) | 2015-05-27 |
| NO2914264T3 (enExample) | 2018-01-06 |
| JP6255028B2 (ja) | 2017-12-27 |
| IL238536B (en) | 2019-01-31 |
| RS56485B1 (sr) | 2018-01-31 |
| RU2015120692A (ru) | 2016-12-27 |
| LT2914264T (lt) | 2017-11-10 |
| ZA201503924B (en) | 2020-11-25 |
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