KR102119966B1 - Compositions for Preventing Hair Loss and Stimulating Hair Sprouting and Method for preparing the same - Google Patents

Abstract

The present invention is based on solid components, 5 to 9 parts by weight of yellow root, 5 to 8 parts by weight of right root, 5 to 8 parts by weight of healthy root, 50 to 80 parts by weight of hazelnut seed, 6 to 8 parts by weight of rhubarb root, and Provides a composition for preventing hair loss and promoting hair growth and a method for manufacturing the same, comprising 5 to 10 parts by weight of a hot water extract of roots of white paper.

Description

Composition for preventing hair loss and stimulating hair loss and stimulating hair sprouting and method for preparing the same}

The present invention relates to a composition for preventing hair loss and promoting hair growth and a method for manufacturing the same.

The causes of alopecia, in which hair is removed from the scalp, are internal factors such as genetic constitution or the action of testosterone, mental stress in daily life, external factors such as accumulation of lipid peroxide in the scalp, and a combination of these factors. Factors are known. Recently, not only male-type hair loss, but also obese hair loss among women, hair loss is gradually spreading among young people. Therefore, in order to improve the hair loss phenomenon, many types of hair loss prevention and hair growth promoting agents have been developed and marketed.

The most commonly known mechanism for improving alopecia symptoms is a mechanism that prevents hair loss and promotes hair growth by controlling male hormones. However, most of the known technologies related to this are insignificant or have serious side effects and thus fail to function safely and efficiently as a hair loss prevention and hair growth promoting agent.

On the other hand, various hair loss prevention and hair growth promoting agents including natural extracts are commercially available. These drugs have a therapeutic mechanism that improves blood circulation of the scalp by improving blood circulation and vasodilation by natural extracts, thereby improving hair loss symptoms.

However, even though these drugs contain natural ingredients as an active ingredient, despite the merit of being safe for the human body, they are ineffective and do not provide satisfactory hair loss improvement effects.

Republic of Korea Registered Patent No. 10-2009-0086670

The present invention has been devised in order to solve the problems of the prior art as described above, and contains natural ingredients as an active ingredient, which is safe for the human body, but provides nutrition to the hair and hair roots to prevent hair loss and promote hair growth. It is an object to provide an accelerating composition and a manufacturing method thereof.

The present invention, in order to achieve the above object,

Based on solids, 5 to 9 parts by weight of yellow root, 5 to 8 parts by weight of right root, 5 to 8 parts by weight of healthy root, 50 to 80 parts by weight of hazelnut seed, 6 to 8 parts by weight of rhubarb root, and 5 to 10 parts by weight Provides a composition for preventing hair loss and promoting hair growth, comprising a hot water extract of the roots of white paper by weight.

In addition, the present invention

(a) immersing the yellowish root and hazelnut seed in ethanol for 2-10 hours, followed by evaporating ethanol to obtain dry yellowish root and hazelnut seed, and dried ethanol extracts thereof;

(b) 200 to 1,800 parts by weight of water based on 100 parts by weight of dry yellow root and hazelnut seeds obtained in step (a), and their ethanol extract, and 90 to under pressure of 0.5 to 5 kgf/cm ² Heating to 120° C. to extract hot water;

(c) step of extracting hot water by heating 400 to 3,600 parts by weight of water based on 100 parts by weight of solid ingredients of the right root, healthy root, rhizome root, and white root, and heating at 90 to 120° C. under a pressure of 0.5 to 5 kgf/cm ² ; And

(d) mixing the hot water extract obtained in the step (b) and the hot water extract obtained in the step (c); provides a method for preventing and preventing hair loss.

The hair loss prevention and hair growth promoting composition of the present invention provides safe and very good hair loss prevention and hair growth promoting effect by including natural ingredients as an active ingredient. In addition, it is possible to obtain the effect of promoting hair growth and making hair healthy by nourishing hair and hair.

Hereinafter, the present invention will be described with reference to preferred embodiments.

The present invention, based on solid components, 5 to 9 parts by weight of yellow roots, 5 to 8 parts by weight of right roots, 5 to 8 parts by weight of healthy roots, 50 to 80 parts by weight of hazelnut seeds, 6 to 8 parts by weight of rhubarb roots, And 5 to 10 parts by weight relates to a hair loss prevention and hair growth promoting composition comprising a hot water extract of the roots of white paper.

When each solid content is included in the above content, a desirable composition for preventing hair loss and promoting hair growth is obtained, and it is difficult to provide a desirable effect when any one component is outside the above-mentioned range.

Particularly, in the case of hazelnut seed, when included as less than 50 parts by weight as the main component of the composition of the present invention, the effect of preventing hair loss and promoting hair growth becomes insignificant, and when it exceeds 80 parts by weight, the content of other ingredients is relatively small, thereby preventing hair loss and It is difficult to provide a balanced effect for promoting hair growth.

The hot water extract is a mixture of hot water extracts obtained by separately performing hot water extraction for each component;

The yellow root and hazelnut seed are subjected to hot water extraction together to obtain a hot water extract, followed by hot water extraction for the right root, healthy root, rhizome root and white paper root to obtain a hot water extract and mixing them;

It may be a hot water extract obtained by adding all the ingredients at once and performing hot water extraction;

At this time, water may be added to 100 to 900 parts by weight per 100 parts by weight of each solid component to proceed with extraction. For example, in the case of the third form, 600 to 5,400 parts by weight of water may be added at once based on 100 parts by weight of the total solid components to extract hot water.

In the hot water extraction, the heating temperature may be performed at 90 to 120°C, more preferably 110 to 120°C.

The hot water extract may be performed under a pressure of 1.5 to 10 kgf/cm ² , and more preferably performed under a pressure of 1.5 to 3 kgf/cm ² . When performing hot water extraction under the pressure as described above, it is preferable because the active ingredient can be more easily extracted, and since water is hardly reduced by evaporation, it is advantageous to repeatedly prepare a suitable concentration composition.

In one embodiment of the present invention, the yellow root and the hazelnut seed are immersed in ethanol for 2 to 10 hours before the hot water extraction, and then the dried yellow root root and its ethanol extract obtained by evaporating ethanol and the hazelnut seed and its ethanol The dried extract may be used for hot water extraction.

In the case of the yellow root root and hazelnut seed, since the active ingredients that are not obtained when extracting only with water as an active ingredient for preventing hair loss and promoting hair growth can be obtained when ethanol is extracted, It can provide better hair loss prevention and ankle promoting effect.

The hair loss prevention and hair growth promotion of the present invention may further include 5 to 10 parts by weight of a fig seed and 5 to 10 parts by weight of a fish root root hot water extract based on solid components together with the above components. The fig seeds and fish roots contain active ingredients that help to prevent hair loss and promote hair growth, so if ingredients are added as above, better hair loss prevention and hair growth promoting effects can be obtained.

The method of extracting the hot water of the fig seed and fish root is the same as the other components.

Yellow hwang (plant name: lamellar hook, Polygonatum Sibiricum Reroute) used in the composition for preventing hair loss and promoting hair growth of the present invention is a perennial plant of the Liliaceae family, the leaves are slender, the leaves are hooked, the flowers have a greenish white color It blooms in May-June, and the fruits are berries.

It is native to Korea (Northern), China, Russia, and Mongolia, and is used as a medicinal herb since it has a nutritional tonic effect and helps to reduce food loss, helplessness, postoperative weakness, pulmonary tuberculosis, and diabetes.

The hair follicle (Arctium Lapped L.) used in the composition for preventing hair loss and promoting hair growth of the present invention is a chrysanthemum (Asterracese) and is a plant, and the perennial leaves are reciprocal, the recent leaves are total, the purple flowers bloom in July, and the fruit is aquatic to be.

It is native to Korea (cultivation), Asia, and Europe, and is used as a medicinal herb because it has diuretic, anti-inflammatory, anti-tumor, anti-tumor, tendon and biliary effects as a medicinal agent.

The health (dry ginger) used in the composition for preventing hair loss and promoting hair growth of the present invention has a plant name of Zingiber Officinale Roscoe, and is a perennial herb, the leaves are linear lanceolate, inflorescence, and flowers are in August. It blooms yellow-green, and the fruit is a fruit.

It is native to Korea (cultivated), Asia, and the tropics. It contains Zingiberene, Camphene, a-pinene, and cineol as essential oils, and 6-shogaol and Zingerone as phenolics components.

As an only medicine, it has the effect of arm and stomach, and is effective in reducing indigestion and vomiting diarrhea.

Hazel used in the composition for preventing hair loss and promoting hair growth of the present invention is an annual herb belonging to the family Fabaceae. It is grown in all regions except the high bulge in northern Korea. It is grown in many countries worldwide.

Hazelnut seeds contain procoumarins such as psoralen, angelicin, psoralidin, coumarin, flavonoids, and isobabakalcon. Purokumarin obtained from hazelnut seeds is known to help relieve alopecia and vitiligo, and when Shinyang suffers from soreness and pain in the lower back and soreness, frequent urination, men's sexual intercourse, semen flows spontaneously, It helps prevent enuresis. In addition, it is known that the spleen and kidneys are indigestible, so they cannot be digested, and even if there is diarrhea every morning or vulgar vitiligo, it is known to have an effect.

Rehmannia glutinous used in the composition for preventing hair loss and promoting hair growth of the present invention is a perennial herb of the Scrophulariaceae, inflorescence, and flowers bloom in reddish purple in June to July, and the fruits are cut, The taste is sweet and bitter and has a peculiar smell.

It is cultivated in Korea and China, and contains Trihydroxy-B-ionone, Sechydroxyaehineti acid as Norcarotenoid components as Iridoid components, Catalpol, Leonuride, Audubon, Melittoside geniposide, Ajugol, etc., and Acteoside, Forsythiaside as Caffeoyl golucose components.

Hemostasis, cardiac action, diuretic action, hypoglycemic action, and is known as a drug that helps to relieve cramping, constipation, and liver function.

The white paper (Angelicae Dahuricse Radix) used in the composition for preventing hair loss and promoting hair growth of the present invention is an antler (Angelica dahurica Bentham et Hooker).

It is a perennial herb of the apiaceae, and its leaves are double idol bilobes, a compound inflorescence, and flowers bloom white in June to August.

It grows around a low pond, has white roots, a peculiar smell, a spicy taste, and warm properties.

It grows in Korea (nationwide), China, Japan, and Russia, and contains Oxtpeucedanin, Imperatorin, Phellopterin, and Oxypeucedanin as furanocoumarin ingredients.

It is known to have antipyretic, analgesic, anti-inflammatory, draining and detoxifying effects as an antipyretic drug.

Figs used in the composition for preventing hair loss and promoting hair growth of the present invention are known to contain twice as much dietary fiber and iron as prunes, and more calcium than milk, about 80% more than banana It is known to contain potassium. It is also known to contain anti-cancer polyphenols.

Looking at the ingredients of the fig, 100 g of fig is known to contain about 12.2 g of dietary fiber, about 133.0 mg of calcium, about 609 mg of potassium, and about 3.0 mg of iron.

The fish head (Heracleum moellendorffii Hance) used in the composition for preventing hair loss and promoting hair growth of the present invention is a perennial plant that grows relatively commonly in the wild mountains of Korea as a plant of the Umbelliferae family. The height of the fishfish is 70 to 150 cm, and the main stem is a hollow columnar shape, characterized by thick branches and large hairs. The leaves sprouting from the root and the leaves at the bottom have petioles, composed of 3 to 5 lobules, and have hairs on the back and petioles of the leaves. The sperm lobe is centrifugal and deeply divided into three, and the lateral lobe is broad ovate or triangular, split into two or three, 7-20 cm, the lobe has a sharp tip, and has a serrated tooth. . The compound inflorescence runs at the end of the branch and at the end of the main stem and is divided into 20~30 small branches, and 25~30 white flowers each run. The calamen is 7-10 cm long, the pedicle is not constant, and the long one reaches 2 m in length and has hair on the inside. Fruits are flat obovate and have a unique pattern near the upper part and no hairs (Lee Chang-bok. 2003. Plant drawings for primary colors. Sangwon. p. 826.).

The roots of oysters are sown in spring, in October, and in the fall, in the following year, when the foliage dries yellow from July to September of the following year, the roots are pruned to remove the stems and fine roots and dried in the sun to store them for use in the treatment of muscle pain, arthritis, and low back pain. In addition, it is also used for treatment of skin itching, boils, headaches, chills, and fever.

In addition, the present invention

(a) immersing the yellowish root and hazelnut seed in ethanol for 2-10 hours, followed by evaporating ethanol to obtain dry yellowish root and hazelnut seed, and dried ethanol extracts thereof;

(b) 200 to 1,800 parts by weight of water based on 100 parts by weight of dry yellow root and hazelnut seeds obtained in step (a), and their ethanol extract, and 90 to under pressure of 0.5 to 5 kgf/cm ² Heating to 120° C. to extract hot water;

(c) step of extracting hot water by heating 400 to 3,600 parts by weight of water based on 100 parts by weight of solid ingredients of the right root, healthy root, rhizome root, and white root, and heating at 90 to 120° C. under a pressure of 0.5 to 5 kgf/cm ² ; And

(d) mixing the hot water extract obtained in the step (b) and the hot water extract obtained in the step (c); and a method for manufacturing a hair loss prevention and hair growth promoting composition.

Regarding the above manufacturing method, all of the contents described above for the composition for preventing hair loss and promoting hair growth may be applied.

The composition for preventing hair loss and promoting hair growth of the present invention can be applied to the human hair by applying it to the hair follicle of the head or drinking it, and provides a more excellent effect when the application and drinking of the hair follicle are used in combination.

When applied to the hair roots, it is preferable to apply the hair roots sufficiently wet, and when drinking, 5 to 100 ml can be taken once to three times a day, more preferably 5 to 20 ml per time. Can be taken. The dosage may be appropriately adjusted according to the body condition after taking.

The composition for preventing hair loss and promoting hair growth of the present invention may be formulated as a cosmetic composition in the form of shampoo or hair tonic, and may be packaged in a disposable pack or container for drinking, and packaged in units of 1 week to 6 months. You may.

In the case of the shampoo, the hair loss prevention and hair growth promotion composition of the present invention may be prepared to be included in 3-20% by weight based on the total weight of the shampoo composition, and in the case of hair tonic, the hair loss prevention and hair growth promotion composition of the present invention is 50~ It may be prepared to include 100% by weight.

Hereinafter, the present invention will be described in more detail through examples. However, the following examples are intended to illustrate the present invention more specifically, but the scope of the present invention is not limited by the following examples. The following examples can be appropriately modified and changed by those skilled in the art within the scope of the present invention.

Preparation Example 1: Preparation of yellow root extract

After washing the dried yellow roots of 5 to 9 g, after drying 90% or more of moisture, it was again immersed in water for 30 minutes, washed second, and then dried over 90% of moisture.

Thereafter, 0.7 liters of water was added to the yellow roots after the second washing was completed, and after bathing under a pressure of 2 kgf/cm ² for 2 hours at 110 to 120° C., moxibustion was carried out for 2 hours, followed by cooling and filtration. To prepare a yellowish extract.

Preparation Example 2: Preparation of the extract of the roots of the right side

After washing 5-8 g of dried right roots, after drying over 90% of moisture, it was immersed again in water for 30 minutes, washed second, and then dried over 90% of moisture.

Thereafter, 0.7 liters of water was added to the roots of the right side of the stalk, which had been completely washed for the second time, and the mixture was bathed under pressure of 2 kgf/cm ² for 2 hours at 110 to 120° C., moistened for 2 hours, cooled and filtered. Right root extract was prepared.

Preparation Example 3: Preparation of healthy root extract

After washing 5 to 8 g of dried healthy roots, 90% or more of moisture was dried, then immersed in water for another 30 minutes, followed by secondary washing to dry more than 90% of moisture.

Thereafter, 0.7 liters of water was added to the healthy roots after the second washing, and after bathing under pressure of 2 kgf/cm ² for 2 hours at 110 to 120° C., moxibustion was performed for 2 hours, followed by cooling and filtration. Healthy root extracts were prepared.

Preparation Example 4: Preparation of hazelnut seed extract

After washing 50 to 80 g of dry hazelnut seeds, after drying 80% or more moisture, soaking in water for another 30 minutes, followed by secondary washing, followed by drying 80% or more moisture.

Thereafter, 0.7 liters of water was added to the hazelnut seed pool after the second washing was completed, and the mixture was bathed under pressure of 2 kgf/cm ² for 1 to 1.5 hours at 110 to 120° C., followed by moxibustion for 2 hours, followed by cooling. , Filtered to prepare a hazelnut seed extract.

Preparation Example 5: Preparation of extracts of rhubarb root

After washing 6 to 8 g of dried rhubarb roots, after drying 80% or more of moisture, it was again immersed in water for 30 minutes, washed second, and then dried over 80% of moisture.

Subsequently, 0.7 liters of water was added to the roots of the turmeric after the second washing was completed, and the mixture was bathed under pressure of 2 kgf/cm ² for 2 hours at 110 to 120° C., followed by moxibustion for 2 hours, cooled and filtered. A curcuma root extract was prepared.

Preparation Example 6: Preparation of white paper root extract

After washing the roots of white paper of 5 ~ 10 g, dried over 90% of moisture, soaked in water for another 30 minutes, washed for a second time, and then dried over 90% of moisture.

Thereafter, 0.7 liters of water was added to the roots of the white paper after the second washing was completed, followed by bathing under a pressure of 2 kgf/cm ² for 2 hours at 110 to 120° C., followed by moxibustion for 2 hours, followed by cooling and filtration. A blank root extract was prepared.

Preparation Example 7: Preparation of yellow root extract

After washing the dried yellow roots of 5 to 9 g, after drying 90% or more of moisture, it was again immersed in water for 30 minutes, washed second, and then dried over 90% of moisture.

Thereafter, after the second washing was completed, the yellowish root was immersed in 30% of ethanol (using 30-degree shochu), extracted for 6 hours, and then removed by evaporation of ethanol.

0.7 liter of water was added to the dried yellow root obtained from the above and its ethanol-extracted dry powder, and then bathed under pressure of 2 kgf/cm ² for 2 hours at 110 to 120° C., followed by moxibustion for 2 hours, followed by cooling. Filtered to prepare a yellowish extract.

Preparation Example 8: Preparation of hazelnut seed extract

After washing 50 to 80 g of dry hazelnut seeds, after drying 80% or more moisture, soaking in water for another 30 minutes, followed by secondary washing, followed by drying 90% or more moisture.

Subsequently, the hazelnut seed that had been subjected to the second washing was immersed in 30% ethanol (using 30-degree soju) for extraction for 6 hours, and then removed by evaporation of ethanol.

0.7 liter of water was added to the dried hazelnut seed paste obtained above and its ethanol-extracted dry powder, and the mixture was bathed under pressure of 2 kgf/cm ² for 1 to 1.5 hours at 110 to 120° C., followed by boiling for 2 hours, followed by cooling. And filtered to prepare a hazelnut seed extract.

Preparation Example 9: Preparation of fruit extract of fig

After washing 5 to 10 g of fig seeds, dried over 90% of moisture, soaked in water for another 30 minutes, washed second, and dried over 90% of moisture.

Thereafter, 0.7 liters of water was added to the fig seed, which had been completed for the second washing, followed by bathing under pressure of 2 kgf/cm ² for 2 hours at 110 to 120° C., followed by moxibustion for 2 hours, cooling, and filtration. Fig seed extract was prepared.

Preparation Example 10: Preparation of fish root (poisonous) root extract

After washing 5-10 g of fish roots (poisonous) roots, after drying over 90% of moisture, they were again immersed in water for 30 minutes, washed second, and then dried over 90% of moisture.

Thereafter, 0.7 liters of water was added to the fish roots after the second washing was completed, and the mixture was bathed under pressure of 2 kgf/cm ² for 2 hours at 110 to 120° C., followed by moxibustion for 2 hours, cooled and filtered. A fish root extract was prepared.

Example 1: Preparation of hair loss prevention and hair growth promoting composition

The hair loss roots and hair growth promoting compositions were prepared by mixing the same amount of yellowish roots, right roots, healthy roots, hazelnut seeds, rhizome roots and white paper root extracts obtained in Preparation Examples 1 to 6.

Example 2: Preparation of a composition for preventing hair loss and promoting hair growth

The hair loss prevention and hair growth promotion compositions were prepared by mixing the same amount of the yellowish roots, the right roots, the healthy roots, the hazelnut seeds, the rhubarb roots and the white root extracts obtained in Preparation Examples 7 to 8, and Preparation Examples 3 to 6.

Example 3: Preparation of hair loss prevention and hair growth promoting composition

In the same amount of the yellow roots, the roots of the roots, health roots, hazelnut seeds, rhubarb roots, white roots, fig seeds, and fish roots obtained in Preparation Examples 7 to 8 and Preparation Examples 3 to 6 and Preparation Examples 9 to 10 Mixing to prepare a composition for preventing hair loss and promoting hair growth.

Comparative Example 1: Preparation for preventing hair loss and promoting hair growth

The brand name “Live Life Nutrient Serum” manufactured by C&T Lab was purchased and used.

Test Example: Experiment to promote hair growth or inhibit hair loss

Test Example 1: People Evaluation of the effect of proliferation of dermal papilla cells

The effects of the compositions of Examples 1 to 3 and the samples of Comparative Example 1 on cell proliferation of human hair dermal papilla cells are as follows: human hair dermal papilla cells (HHDPC) ( Sciencell, cat. no. 2400).

In human cell papilla cells (Sciencell, cat. no. 2400) in a medium containing MSC (Mesenchymal Stem Cell), a dedicated medium containing 10% FBS (fetal bovine serum, Cambrex), make 0.5 × 10 ⁴ cells in a 96-well plate. Inoculated and incubated for 24 hours at 37°C under 5% CO ₂ wet conditions. After treating the samples at a concentration of 10 µg/ml in the culture solution and incubating for 72 hours, 5 mg of MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide) reagent 20 µl was added to the culture solution, and cultured at 37° C. under 5% CO ₂ wet conditions for 4 hours. When cultured, purple crystals are formed in living cells. After incubation for 4 hours, the medium was removed, DMSO 100 was added, the crystal was dissolved in a shaking incubator for 10 minutes, and the absorbance was measured at 570 nm to measure the degree of cell growth. The test results are shown in Table 1 below as a percentage of the control-free group.

division Proliferation rate (%) Control group (untreated group) 100 Comparative Example 1 Serum treatment group (commercially available product name "Lively Nutrient Serum" treatment) 115 Composition treatment group of Example 1 (yellow root, right root, healthy root, hazelnut seed, rhubarb root, and white water root hot water extract) 123 Composition treatment group of Example 2 (hot water extract of the right root, healthy root, rhizome root, and white paper root; and extract by hot water extraction after ethanol extraction of the yellow root and hazelnut seed) 125 Composition treatment group of Example 3 (hot water root, healthy root, rhizome root, baekji root, fig seeds, and fish roots of hot water extract; and ethanol extract of yellow root and hazel seed after extract by hot water extraction) 127

According to the results of Table 1, it was confirmed that the samples of the Examples of the present invention promote prominent proliferation of dermal papilla cells compared to the control and the compositions of Comparative Example 1. In particular, the compositions of Examples 2 and 3 were found to better promote the proliferation of dermal papilla cells.

Test Example 2: Evaluation of human keratinocytes (HaCaT cell) proliferation effect

The composition of Examples 1 to 3, and the effect of the sample of Comparative Example 1 on the cell growth of human keratinocytes, using keratinocytes (HaCaT cell) (Dr. NE Fusenig (Heidelberg, Germany)) , It was evaluated in the same manner as in Test Example 1. The medium was used as RPMI medium containing 10% FBS (fetal bovine serum, Cambrex) The test results are shown in Table 2 below as a percentage of the control-free group. .

Test group Proliferation rate (%) Control group (untreated group) 100 Comparative Example 1 Serum treatment group (commercially available product name "Lively Nutrient Serum" treatment) 117 Composition treatment group of Example 1 (yellow root, right root, healthy root, hazelnut seed, rhubarb root, and white water root hot water extract) 126 Composition treatment group of Example 2 (hot water extract of the right root, healthy root, rhizome root, and white paper root; and extract by hot water extraction after ethanol extraction of the yellow root and hazelnut seed) 128 Composition treatment group of Example 3 (hot water root, healthy root, rhizome root, baekji root, fig seeds, and fish roots of hot water extract; and ethanol extract of yellow root and hazel seed after extract by hot water extraction) 131

According to the results of Table 2, it was confirmed that the samples of the Examples of the present invention promoted proliferation of keratinocytes significantly compared to the control and the compositions of Comparative Example 1. In particular, the compositions of Examples 2 and 3 were found to better promote the proliferation of keratinocytes.

Test Example 3: Clinical trial for hair loss prevention and hair growth promoting effect

Alopecia patients (7 males in their 30s and 50s in each experimental group) twice a day (morning and evening) by putting 100 ml of the compositions of Examples 1 to 3 of the present invention and samples of Comparative Example 1 in a spray container. 3) sprayed on the scalp of the hair loss area and confirmed the effect. The test was run for 15 weeks.

When the alopecia patient visited the hospital for the first time, the condition of the hair was diagnosed, the alopecia area was marked and recorded, and the black spot was tattooed on the most severe area to measure the same area at every measurement. Then, the number of hairs per unit area of the hair loss area (number of hairs/cm 2) was measured using a simple hand-held phototricho gram (Folliscope, Lead M Co, Seoul, Korea). The number of hairs per unit area was calculated using a 30-fold lens, and the number of terminal hairs in a unit area was calculated after photographing the hair loss area around the display area.

Changes in the number of hairs (number of hairs/cm 2) measured at a predetermined time point after drug administration and before drug administration of the alopecia patients are shown in Table 3 below.

Subject number Measurement time
(Increased number of hair) 3 weeks 6 weeks 9 weeks 12 weeks 15 weeks Serum treatment group of Comparative Example 1
(Commercial product name “Birthday Nutrient Serum”) One One 3 5 6 7 2 2 3 6 6 9 3 2 4 4 6 8 4 4 2 8 10 13 5 3 6 7 8 9 6 0 2 5 6 9 7 One 3 4 8 10 8 3 4 3 6 9 9 0 3 4 7 9 10 One 2 4 7 11 Average 1.7 3.2 5.0 7.0 9.4 Composition treatment group of Example 1
(Hermal root, right root, healthy root, hazel seed, rhubarb root, and hot water extract of white paper root) One 3 6 8 10 12 2 One 3 5 8 11 3 3 4 7 10 14 4 3 5 7 10 13 5 4 4 6 9 11 6 3 6 9 13 15 7 2 3 6 9 12 8 3 5 10 14 16 9 2 5 8 12 14 10 6 8 11 13 15 Average 3.0 4.9 7.7 10.8 13.3 Composition treatment group of Example 2
(Hot roots, healthy roots, rhizome roots, and hot water extracts from white roots; and extracts by hot water extraction after ethanol extraction of yellow root and hazelnut seeds) One 2 4 8 12 16 2 4 6 9 11 15 3 2 5 7 10 13 4 3 5 8 12 16 5 4 5 7 10 13 6 3 5 7 9 13 7 4 7 11 15 17 8 2 4 7 10 13 9 5 7 12 15 17 10 2 4 8 11 14 Average 3.1 5.2 8.4 11.5 14.7 Composition treatment group of Example 3
(Hot roots, healthy roots, rhizome roots, white paper roots, fig seeds, and fish roots of hot water extracts; and extracts by hot water extraction after ethanol extraction of yellow root roots and hazelnut seeds) One 4 6 11 15 18 2 3 7 10 12 16 3 2 3 6 9 12 4 4 7 13 16 19 5 2 4 6 9 13 6 3 5 7 9 13 7 4 7 11 14 17 8 2 4 7 11 13 9 5 7 10 15 18 10 4 6 9 13 17 Average 3.3 5.6 9.0 12.3 15.6

As shown in Table 4, compared to the case where the serum of Comparative Example 1 was applied, it can be seen that in the case of the test groups to which the compositions of Examples 1 to 3 of the present invention were applied, the number of hairs was significantly increased.

In particular, it can be seen that in the case of Examples 2 and 3 of the present invention, the increased number of hairs is more remarkable.

Test Example 4: Evaluation of side effects

The side effects of the samples of Examples 1 to 3 and the samples of Comparative Example 1 used in the process of Test Example 3 were confirmed through a questionnaire, and the results are shown in Table 4 below.

Example 3 Hair Tonic Example 3 Hair Tonic Comparative Example 2 Hair Tonic Number of subjects 30 people 30 people 30 people Abandoned treatment (for 15 weeks) 0 people 0 people 0 people Number of side effects 0 people 0 people 0 people

As shown in Table 4, the composition for preventing hair loss and promoting hair growth of the present invention was found to be very safe because no side effects were exhibited and no treatment abandoners occurred.

Claims (6)

Based on solids, 5 to 9 parts by weight of yellow root, 5 to 8 parts by weight of right root, 5 to 8 parts by weight of healthy root, 50 to 80 parts by weight of hazelnut seed, 6 to 8 parts by weight of rhubarb root, 5 to 10 parts by weight Includes a wealth of white paper root, 5 to 10 parts by weight of fig seeds, and 5 to 10 parts by weight of fish roots, hot water extract,
The hwangjeong root and hazelnut seed hot water extract is immersed in ethanol for 2-10 hours before hot water extraction, followed by hot water extraction of the yellow root root obtained by evaporating ethanol and its dry extract of ethanol extract and the dry extract of hazelnut seed and its ethanol extract. Will
The hot water extraction is from 100 to 900 parts by weight per 100 parts by weight of each solid component under a pressure of 1.5 to 10 kgf/cm ² and extracted at a temperature of 90 to 120° C. The composition for preventing hair loss and promoting hair growth. delete delete delete delete delete