KR101052321B1 - Athlete's foot therapeutic composition - Google Patents

Abstract

The present invention includes at least one or more of fat milk, black yam, raw sulfur, fermented and pulverized fermented product, March is included as a burned remnant, at least one of brier roots, ringworm skin, gentian, red ginseng is included as an extract , Blue vine leaf provides a athlete's foot treatment composition, in particular, the athlete's foot athlete's foot treatment composition contained in the pulverized powder. Athlete's foot treatment composition according to the present invention can minimize side effects by using a herbal or plant material that has been proven to be safe for humans even after long-term use, and directly applied to the athlete's foot disease site, especially in the treatment of nail athlete's foot Has excellent efficacy

Athlete's foot, nail athlete's foot, ringworm

Description

Athlete's foot therapeutic composition {Pharmaceutical composition for application to tinea pedis}

The present invention relates to athlete's foot therapeutic compositions, in particular to nail athlete's foot therapeutic compositions.

Athlete's foot (tinea pedis) and nail fungal infections (onychomycosis), also known as nail athlete's foot, are a widespread disease worldwide. This chronic pathological presence, which is not self-healing, is of increasing importance, especially in highly developed industrialized countries. Nail athlete's foot constitutes the most common disease of nails, including up to 40% of proportions. The prevalence of nail athlete's foot is officially announced in the art to be 2.8% to 8.4%. Mycosis of nails accounts for about 30% of all skin fungal diseases. Epidemiologic studies have shown that 20% to 30% of patients with Tinea pedis also have nail athlete's foot.

Many patients feel atrophy in their social interactions, especially if they have anchovy tinnitus on their apparent nails.

In addition, pathological events are limited in tactility, motility and manual ability. The need for treatment also stems from the fact that ringworm is the cause of the spread of the disease from the nails to the skin as the source of infection. It also represents a risk of infection in a constantly growing population.

Since the early 1990s, a number of new treatments have been developed for treating ringworm. On the one hand, novel systemic active antifungal agents; For example itraconazole (US Pat. No. 4,267,179); (E) -N- (6,6-dimethyl-2-hepten-4-ynyl) -N-methyl-1-naphthalenemethanamine (also named terbinafine); α- (2,4-difluorophenyl) -α- (1H-1,2,4-triazol-1-ylmethyl) -1H-1,2,4-triazole-1-ethanol [fluconazole ( As well as fluconazole, there are also locally used lacquer preparations that make treatment of ringworm better.

Systemic treatment requires active ingredients to reach the infected site through the blood circulation, so in some situations unwanted and serious side effects of the drug can occur, which can sometimes be life-threatening. Side effects and infections with other agents are inevitable, especially in many elderly patients with high mortality. Systemic antifungal agents additionally have other undesirable side effects, such as differences in the range of pathogens that can be treated, in some cases differences in unreliable absorption.

The disadvantage of combined treatment with topical and systemic antifungal agents in the treatment of ringworm is that even patients treated with the therapy still have a heavy pressure on the system with all the associated side effects. Another important drawback is the low amount of systemic antifungal agents that reach the nails. Also to date, only very complex and fundamental methods have been possible, whereby topically applying systemic antifungal agents, such as itraconazole, to the nail in therapeutically effective concentrations.

Accordingly, an object of the present invention is to use a high-safety material for long-term use in consideration of the above-mentioned problems, and athlete's foot treatment composition that can minimize the side effects by applying directly to the athlete's foot disease site, especially nail foot disease site treatment To provide.

As a means for achieving the object of the present invention,

The present invention is a fermentation product obtained by fermenting ground sulfur, fermented raw milk, brown fat, 40-80 parts by weight of fermented milk fat, 10-40 parts by weight of fermented soybean paste, and 10-40 parts by weight of raw sulfur fermented product; 10-30 parts by weight of residue burned Machi; 3 ~ 10 parts by weight of Dokomari, 3 ~ 10 parts by weight of brier roots, 3 ~ 10 parts by weight of ringworm skin, 3 ~ 10 parts by weight of gentian, and 3 ~ 10 parts by weight of red ginseng in a container with water part; It provides a athlete's foot treatment composition comprising a;

In addition, 10 ~ 160 parts by weight of the fermented milled by fermenting at least one or more of fat milk, black horse, raw sulfur; 10-30 parts by weight of residue burned Machi; 3 to 50 parts by weight of extract extracted by putting at least one or more of dokomari, brier roots, ringworm skin, gentian, red ginseng with water; It provides a athlete's foot treatment composition comprising a;

In addition, fermented products obtained by fermenting at least one or more of fat milk, black roe, raw sulfur; Remnants burning Machi Prefecture; An extract obtained by putting iron at least one or more of oxtail, brier root, ringworm skin, gentian and red ginseng into a container with water and extracting it; And pulverized crushed blue rice vine leaves; provides a athlete's foot treatment composition comprising a.

In addition, 40 parts by weight of fat milk, 20 parts by weight of the horseradish, 10 parts by weight guchi, 10 parts by weight of raw sulfur to provide a athlete's foot therapeutic composition comprising a fermented and ground.

At least one or more of the fat, yam, raw sulfur of the present invention is included as a fermented and crushed fermentation, March prefecture is included as a burned residue, at least one of brier roots, ringworm skin, gentian, red ginseng is included as an extract , Athlete's foot treatment composition, which contains crushed crushed leaves, uses Chinese medicine or plant material that has been proven to be safe for humans even after long-term use, and is applied directly to athlete's foot disease areas, especially nail foot disease areas. By minimizing the side effects, it can be seen to have excellent efficacy in treating nail athlete's foot.

Hereinafter, the present invention will be described in more detail with reference to Examples. The following descriptions are for specific examples of the present invention, but are not intended to limit the scope of the rights set forth in the claims, even if there is an assertive or limited expression.

Athlete's foot treatment composition according to an embodiment of the present invention is fermented by grinding at least one fermentation of at least one of fat milk, black yam, raw sulfur; Remnants burning Machi Prefecture; An extract obtained by putting iron at least one or more of oxtail, brier root, ringworm skin, gentian and red ginseng into a container with water and extracting it; And a pulverized product of crushed blue rice vine leaves.

In the present invention, the optimum combination for the treatment of athlete's foot, especially nail athlete's foot, has been invented, and in order to further improve the effect, the composition is characterized in that the combination of fermented product, residue, extract and ground product.

In other words, it is preferable to include the fat milk, yam, and raw sulfur in fermented and crushed fermented products. It is preferable that it is contained in the extract extracted iron, and it is more preferable that blue vine leaves are contained in the pulverized powder. Double port may also be included as fermentation if necessary.

Athlete's foot, which is named in the present invention, is a broad meaning that includes both athlete's foot, such as hands and feet, and athlete's foot.

Jigui (地 楡, Sanguisorbae Radix) is the root of cucumber and coriander root plants. It has the effect of cystic hemostasis, detoxification and dental floss in oriental medicine, and has been used for hemorrhage, hemostasis, blue, hydration, and carbuncle.

Cama is a year-old herbaceous plant, common to native fields in all parts of Korea, fields, roadsides, and grasslands. It grows on the roadside or field of lowlands and has a height of 20 ~ 90 ㎝. Branches spread a lot and some ridges appear on the main stem. The name of the Chinese medicine is Yonggyu (Dongryu, dried grass), the outpost (全 草) and fruit has long been used as a medicine to treat boils and malignant swelling in the private sector. The book of synonym published in North Korea and the old literature of China in Korea say, "It tastes bitter, detoxifies, lowers heat, and circulates blood well. It helps to urinate, removes inflammation and suppresses tumors. It is used for chemotherapy. "

Among the crows growing in Korea, the scientific name is indicated as Solanum nigrumLinnaeus (US name: Black Nightshade) of Solanaceae in most plants, but according to the recent taxonomy Solanum ptycanthum (US name: Eastern Black Nightshade) It is classified. The two species have almost similar morphology, but the biggest difference is that there are no sclerotic granules in the fruit of Solanum nigrum Linnaeus, but Solanum ptycanthum has about 40-50 seeds per fruit inside the fruit.

Rehmannia glutinosa Libschitz var.purpurea Makino uses fresh roots of perennial herbaceous plants belonging to the family Ginsengaceae as a medicine. Fresh root roots of fresh or seonjihwang, dried dried kohwanghwang, raw sulfur added to Hwangju (黃酒) steamed and sun dried 9 times repeated is also known as sujijihwang.

Portulaca is an outpost of purslane (Portulaca oleracesa L.), and its main ingredients are Alanine, Aspartic acid, Oleic acid, Phorbic acid, Vitamin C, Dopamine, Saponine, Tannin, etc. It is used widely for skin diseases because it has the inhibitory effect of dysentery, Staphylococcus aureus, active peristalsis of the intestine, diuretic effect, and excellent wound healing effect. .

Xanthium strumarium L. belongs to the family Asteraceae (Compositae), with hairs all over, its stem is straight, and its length is about 1.5 m. Flowers bloom from August to September at the tip of stem with yellowish-brown head flowers. The fruit is similar to jujube seed, and has thick hairs in the shape of pericarp. It is an annual herb that grows mainly in fields or roadsides, and is widely distributed and grown in Northeast Asia and Europe including Korea. Studies on the larvae are known to be the origin of the Chinese spearfish (Xanthium sibiricum Patr. Ex Widd), which is effective for fever, sweating, analgesic, mountain breeze, roughness, neuralgia and malignant tumors.

Rosa multiflora is a deciduous shrub of the family Rosaceae and is widely distributed in foothills and river basins throughout the country. In oriental medicine, fruit is used as a drug called Youngsil, and it is known to be effective in insomnia, forgetfulness, decreased sexual function, and edema. It is also used as a diuretic. In one embodiment of the present invention, the root of the brier is used.

Dictamnus dsycarpus Turez is a perennial herb that grows about 50-100 cm. It grows in the low hills of various parts of the country, with white or pink flowers in summer. Sheep smelling from this plant is known as ringworm and baekyangseon. In the autumn, digging roots, washing with water, peeled and dried. Ingredients include 0.13% alkaloids in the roots, 0.02% to 0.03% in the root bark, methhamine, triconelline, choline, dictamnolactone, proxinelon, dictamnolide, and obaku. Paddy, saponin, camphorsterol, cytosterol, essential oils and the like. It is known as an important medicine used for quadriplegic anxiety in oriental medicine, and it is used as a parasitic medicine, and it is a fever lowering medicine, analgesic medicine, acupuncture medicine, analgesic medicine, sedative medicine, etc. Used as a diuretic.

Gentianae Scabrae Radix is large and is known for its excellent heat and humidity control. It is especially known for its excellent moist heat. It has the property of sedimentation, so it is good to kill the fire loss of hepatobiliary bile. Its ingredients include geniopicrin and Swertiamarin. Gentianine, Gentisin, Gentianose and the like are known.

Ginseng (Sophora angustifolia SIEB. Et Zucc) is a perennial herb, a perennial herb that grows to 1m in height when grown. Its leaf shape is similar to the painting tree, which is nicknamed worms, lumps and wild beasts. The roots are washed and dried in autumn, and the taste is bitter, but it is called ginseng because it has the same effect as ginseng. As a component of red ginseng, there are alkaloids throughout the plant. The total alkaloid of the root is 1.1%, and the components of the alkaloid include matrin (sofocarpidine), oxymatrine, sophoranol, anagirin, methylcytizin, barbifflin, sofocarpine, and allomatine. In addition, there is about 13% sugar, and the flavonol compounds isoanhydroicaridine, noranhydroicaridine, etc. were separated from the root.

Cheongmirae vine is also known as Myeonggam wood, and if you look at the medicinal effects described in the synonym dictionary, the taste is hearty and the properties are flat. It acts on the stomach and liver. Lowers heat, decays, and poisons. Bones are sore, syphilis, playing, boil, bad, mercury poisoning. Eat 10-15g per day in the form of decoctions, medicines, powdered pills, pills. Fruits are edible and young sprouts are eaten as herbs. Roots are effective for diuresis, detoxification, gusts, etc. Used for arthritis, back pain, and boils. In addition, the contents of the synonym dictionary stated, "Since there are many people who prefer women in herbaceous trees these days, many sexually transmitted diseases such as syphilis have become popular. Because they often recur after using medicine, they suffer a long time. The effect is good. "

As a more preferred embodiment of the present invention, the athlete's foot treatment composition is 10 ~ 160 parts by weight of fermented crushed by fermenting at least one or more of fatty milk, black yam, raw sulfur, 10 ~ 30 parts by weight of the residue burned machi, dokmari, brier roots At least one or more of ringworm, gentian, and red ginseng are put in a container with water, and 3 to 50 parts by weight of extracted extract, and 10 to 30 parts by weight of pulverized crushed blue vine leaves. The weight part used by this invention means the weight ratio of each component.

More preferably, the athlete's foot therapeutic composition is a fermented product obtained by fermenting fat milk, yam, and raw sulfur, 40-80 parts by weight of fermented milk, 10-40 parts by weight of fermented milk, 10-40 parts by weight of fermented sulfur, Machi 10-30 parts by weight of residues burned, 3-10 parts by weight of Dokomari, 3-10 parts by weight of brier roots, 3-10 parts by weight of ringworm skin, 3-10 parts by weight of gentian, 3-10 parts by weight of red ginseng 3 to 50 parts by weight of the extract extracted and put into the iron, and 10-30 parts by weight of the pulverized ground crushed blue vine leaf is good.

In another embodiment, the athlete's foot therapeutic composition may be made of 40 parts by weight of fat milk, 20 parts by weight of yam, 10 parts by weight of gut string, 10 parts by weight of fermented soybeans, fermented and ground. In addition to the residue, the extract, it may further comprise a pulverized product.

The athlete's foot treatment composition may be used as an external preparation such as gel, lotion, cream, ointment according to a conventional method. In general, known ingredients added to external preparations can be used without limitation, and various ingredients to aid drug transport can be added. As an example, glycerin and surfactant are mentioned as a solvent and a support | carrier. Moreover, it can manufacture by adding various well-known additives, for example, antioxidant, a fragrance | flavor, a coloring agent, a preservative, etc. in the range which does not impair the effect of this invention. Examples of such additives include antioxidants such as butylhydroxyanisole and dibutylhydroxytoluene; Preservatives such as paraoxy benzoic acid ester or dihydro acetic acid; Chelating agents, such as disodium edetate or tetrasodium edetate, purified water, etc. can be illustrated.

Example-Preparation of Athlete's Foot Treatment Composition

1. Put the milk, yam, and raw sulfur in the earthenware soaked in water of 10% of sugar in the earthenware, ferment for 30 days to 60 days, and then crush it finely. It was.

2. After drying 500g of dried gut string, put it in a sealed container for 20-30 days, discarded the ash and prepared 10-30g.

3. Put 3-10g of Docomari, 3-10g Brier Root, 3-10g White Pine, 3-10g Gentian, and 3-10g of Red Ginseng into a container, add 1 liter of water, and steam for 40 to 60 minutes, and then extract 50g. Was prepared.

4. 10-30 g of blue vine leaves were prepared by grinding.

5. The above contents were mixed with 3-15 g of glycerin to prepare athlete's foot therapeutic composition.

Clinical Example-Test of efficacy of athlete's foot treatment composition

<Clinical example 1>

(1) Patients: 45 years old female

(2) Symptoms: Athlete's foot occurs on the nails and toenails as shown in Figure 1a

(3) Treatment: Incorporate the nail athlete's foot athlete's foot therapeutic composition obtained in the Example into the affected area three times daily.

(4) Progress: cured with 35 days of treatment as in FIG. 2A.

<Clinical example 2>

(1) Patients: 48 year old male

(2) Symptoms: Athlete's foot occurs on the thumb as shown in Figure 2a

(3) Treatment: The nail athlete's foot treating composition obtained in the Example is included in the affected area once daily.

(4) progress: cured with 45 days treatment as in FIG. 2b.

<Clinical example 3>

(1) Patients: Male 32 years old

(2) Symptoms: Athlete's foot occurs on all nails as shown in Figure 3a

(3) Treatment: The athlete's foot therapeutic composition obtained in Example is included in the affected area three times daily.

(4) Course: Completed with 55 days treatment as in FIG. 3b.

1 to 3 are photographs before and after the clinical treatment for the patient using the athlete's foot treatment composition according to an embodiment of the present invention.

Claims (4)

Fermented products obtained by fermenting the fat and fat of brown milk, black horse, raw sulfur, 40-80 parts by weight of fat milk fermented product, 10-40 parts by weight of fermented milk, 10-40 parts by weight of fresh sulfur fermented product; 10-30 parts by weight of residue burned Machi; 3 ~ 10 parts by weight of Dokomari, 3 ~ 10 parts by weight of brier roots, 3 ~ 10 parts by weight of ringworm skin, 3 ~ 10 parts by weight of gentian, and 3 ~ 10 parts by weight of red ginseng in a container with water part; And Athlete's foot treatment composition comprising; 10 ~ 30 parts by weight of crushed crushed blue vine leaves. 10 to 160 parts by weight of fermented milled by fermenting at least one or more of the fat, brown yam, raw sulfur; 10-30 parts by weight of residue burned Machi; 3 to 50 parts by weight of extract extracted by putting at least one or more of dokomari, brier roots, ringworm skin, gentian, red ginseng with water; And Athlete's foot treatment composition comprising; 10 ~ 30 parts by weight of crushed crushed blue vine leaves. Fermented products obtained by fermenting at least one or more of fat milk, black sea buckwheat and raw sulfur; Remnants burning Machi Prefecture; An extract obtained by putting iron at least one or more of oxtail, brier root, ringworm skin, gentian and red ginseng into a container with water and extracting it; Athlete's foot treatment composition comprising a; Athlete's foot therapeutic composition comprising 40 parts by weight of fat milk, 20 parts by weight of yam, 10 parts by weight of machi Prefecture, 10 parts by weight of raw sulfur and fermented and ground.

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