KR102090934B1 - 마이크로유체 반응기 시스템 - Google Patents

마이크로유체 반응기 시스템 Download PDF

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KR102090934B1
KR102090934B1 KR1020147018969A KR20147018969A KR102090934B1 KR 102090934 B1 KR102090934 B1 KR 102090934B1 KR 1020147018969 A KR1020147018969 A KR 1020147018969A KR 20147018969 A KR20147018969 A KR 20147018969A KR 102090934 B1 KR102090934 B1 KR 102090934B1
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bellows
fluid
reaction chamber
pump
chamber
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KR20140110925A (ko
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씨. 프레더릭 배트렐
존 클레멘즈
이삭 스프레이그
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퍼킨엘머 헬스 사이언시즈, 아이엔씨.
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    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/50273—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means or forces applied to move the fluids
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01F—MIXING, e.g. DISSOLVING, EMULSIFYING OR DISPERSING
    • B01F31/00—Mixers with shaking, oscillating, or vibrating mechanisms
    • B01F31/65—Mixers with shaking, oscillating, or vibrating mechanisms the materials to be mixed being directly submitted to a pulsating movement, e.g. by means of an oscillating piston or air column
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/04—Exchange or ejection of cartridges, containers or reservoirs
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0684—Venting, avoiding backpressure, avoid gas bubbles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0689—Sealing
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/14—Process control and prevention of errors
    • B01L2200/141—Preventing contamination, tampering
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/16—Reagents, handling or storing thereof
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/02—Identification, exchange or storage of information
    • B01L2300/021—Identification, e.g. bar codes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/04—Closures and closing means
    • B01L2300/041—Connecting closures to device or container
    • B01L2300/043—Hinged closures
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0609—Holders integrated in container to position an object
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0627—Sensor or part of a sensor is integrated
    • B01L2300/0636—Integrated biosensor, microarrays
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0822—Slides
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0867—Multiple inlets and one sample wells, e.g. mixing, dilution
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0877—Flow chambers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0887—Laminated structure
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/12—Specific details about materials
    • B01L2300/123—Flexible; Elastomeric
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/14—Means for pressure control
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/043—Moving fluids with specific forces or mechanical means specific forces magnetic forces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0433—Moving fluids with specific forces or mechanical means specific forces vibrational forces
    • B01L2400/0439—Moving fluids with specific forces or mechanical means specific forces vibrational forces ultrasonic vibrations, vibrating piezo elements
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
    • B01L2400/0487—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure fluid pressure, pneumatics
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0475—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure
    • B01L2400/0487—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure fluid pressure, pneumatics
    • B01L2400/049—Moving fluids with specific forces or mechanical means specific mechanical means and fluid pressure fluid pressure, pneumatics vacuum

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Clinical Laboratory Science (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Physical Or Chemical Processes And Apparatus (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Reciprocating Pumps (AREA)
  • Sampling And Sample Adjustment (AREA)
KR1020147018969A 2012-01-09 2013-01-09 마이크로유체 반응기 시스템 Active KR102090934B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US13/346,615 2012-01-09
US13/346,615 US9056291B2 (en) 2005-11-30 2012-01-09 Microfluidic reactor system
PCT/US2013/020869 WO2013106458A2 (en) 2012-01-09 2013-01-09 Microfluidic reactor system

Publications (2)

Publication Number Publication Date
KR20140110925A KR20140110925A (ko) 2014-09-17
KR102090934B1 true KR102090934B1 (ko) 2020-03-19

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EP (1) EP2802417B1 (cg-RX-API-DMAC7.html)
JP (1) JP6190822B2 (cg-RX-API-DMAC7.html)
KR (1) KR102090934B1 (cg-RX-API-DMAC7.html)
CN (1) CN104136123B (cg-RX-API-DMAC7.html)
WO (1) WO2013106458A2 (cg-RX-API-DMAC7.html)

Families Citing this family (75)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US10518262B2 (en) 2012-12-21 2019-12-31 Perkinelmer Health Sciences, Inc. Low elasticity films for microfluidic use
US10065186B2 (en) 2012-12-21 2018-09-04 Micronics, Inc. Fluidic circuits and related manufacturing methods
US20150346097A1 (en) 2012-12-21 2015-12-03 Micronics, Inc. Portable fluorescence detection system and microassay cartridge
WO2014182847A1 (en) 2013-05-07 2014-11-13 Micronics, Inc. Device for preparation and analysis of nucleic acids
JP6472788B2 (ja) 2013-05-07 2019-02-20 マイクロニクス， インコーポレイテッド 粘土鉱物およびアルカリ性溶液を使用して核酸含有試料を調製するための方法
WO2014182844A1 (en) 2013-05-07 2014-11-13 Micronics, Inc. Microfluidic devices and methods for performing serum separation and blood cross-matching
DE102013220445B4 (de) * 2013-10-10 2016-04-07 Robert Bosch Gmbh Auslaufschutzeinheit für eine mikrofluidische Vorrichtung, mikrofluidische Vorrichtung, Verfahren zum Betreiben einer solchen Auslaufschutzeinheit und Verfahren zum Herstellen einer solchen Auslaufschutzeinheit
DE102013221525A1 (de) * 2013-10-23 2015-04-23 Robert Bosch Gmbh Analyseeinheit zur Durchführung einer Polymerase-Kettenreaktion, Analysevorrichtung, Verfahren zum Betrieb einer solchen Analyseeinheit und Verfahren zum Herstellen einer solchen Analyseeinheit
US10076751B2 (en) * 2013-12-30 2018-09-18 General Electric Company Systems and methods for reagent storage
US10634590B2 (en) * 2014-03-11 2020-04-28 Emd Millipore Corporation IHC, tissue slide fluid exchange disposable and system
WO2015161275A1 (en) 2014-04-18 2015-10-22 Bio-Rad Laboratories, Inc. Microfluidic devices for automated assays
WO2015175188A1 (en) * 2014-05-14 2015-11-19 General Electric Company Microfluidic flow cell assemblies for imaging and method of use
WO2016031412A1 (ja) * 2014-08-25 2016-03-03 コニカミノルタ株式会社 反応方法、検出方法および検出装置
CN104568557A (zh) * 2014-12-22 2015-04-29 珠海迪尔生物工程有限公司 一种用于固定玻片的夹具
US9878329B2 (en) * 2015-03-23 2018-01-30 SYFR, Inc. Self-contained slide receptacle for patient specimens
CN105214744A (zh) * 2015-10-26 2016-01-06 深圳华迈兴微医疗科技有限公司 一种磁微粒化学发光微流控芯片
EP3162229B1 (en) 2015-10-28 2022-03-30 Fontem Holdings 1 B.V. Electronic smoking device with a variable-volume liquid reservoir
BR112018008386B1 (pt) * 2015-10-30 2023-01-24 Merck Patent Gmbh Dispositivo e conjunto de preparação de amostra
CN105424449A (zh) * 2015-11-11 2016-03-23 刘洋 一种用于切片染色的导流体结构及切片染色方法
KR102521127B1 (ko) * 2016-02-19 2023-04-13 퍼킨엘머 헬스 사이언시즈, 아이엔씨. 미세유체 혼합 장치 및 방법
CN105891049B (zh) * 2016-04-13 2018-11-23 青岛科技大学 一种研究流体流变行为的方法及狭缝流变仪
CN109716102B (zh) * 2016-09-16 2023-05-16 芯片生物技术株式会社 微粒分注装置、微粒分析装置、反应检测装置、以及使用它们的方法
CA3038716C (en) * 2016-09-30 2024-05-21 Tel-Array Diagnostics Inc. Microfluidic device
EP3523622B1 (en) * 2016-10-06 2025-04-30 Ventana Medical Systems, Inc. System, method and kit for sample preparation
JP6886023B2 (ja) * 2016-12-30 2021-06-16 ロッシュ ダイアグノスティクス ヘマトロジー インコーポレイテッド 試料処理システムおよび方法
US11213824B2 (en) 2017-03-29 2022-01-04 The Research Foundation For The State University Of New York Microfluidic device and methods
CN107129930B (zh) * 2017-06-09 2019-11-26 北京百康芯生物科技有限公司 一种全集成核酸检测微流控芯片及其使用方法
CN107606252B (zh) * 2017-08-02 2024-04-30 南京岚煜生物科技有限公司 用于微流控芯片的无源单向阀
CN107557452A (zh) * 2017-08-02 2018-01-09 南京岚煜生物科技有限公司 一种用于核酸扩增检测的微流控芯片
GB2569344A (en) * 2017-12-14 2019-06-19 Randox Laboratories Ltd Fluidic card assembly
US10792594B2 (en) 2017-12-28 2020-10-06 Replegin Corporation Dual pumping arrangement for a hollow fiber filter
DE102018200520A1 (de) * 2018-01-15 2019-07-18 Robert Bosch Gmbh Verfahren zum Bereitstellen einer Lösung der Substanz in einer mikrofluidischen Vorrichtung
CN112946302B (zh) * 2018-01-16 2022-05-03 株式会社爱蓓儿 血液凝固时间测量用卡匣以及血液凝固时间测量装置
JP6456530B1 (ja) * 2018-01-16 2019-01-23 株式会社アペレ 血液凝固時間測定用カートリッジ及び血液凝固時間測定装置
EP3749453A4 (en) * 2018-02-07 2021-12-15 The Trustees of the University of Pennsylvania HIGH RATE MICROFLUIDIC DEVICE
US10046322B1 (en) 2018-03-22 2018-08-14 Talis Biomedical Corporation Reaction well for assay device
EP3636344A1 (en) * 2018-10-09 2020-04-15 Universiteit Maastricht Sample carrier module
KR102151648B1 (ko) * 2018-12-03 2020-09-03 광운대학교 산학협력단 미세유체 접속 장치
JP7397069B2 (ja) * 2018-12-20 2023-12-12 ライカ・バイオシステムズ・メルボルン・プロプライエタリー・リミテッド スライドトレイアセンブリ
CN109735430B (zh) * 2019-01-28 2021-12-14 武汉纺织大学 一种三维磁泳分离的微流控芯片
US11061045B2 (en) * 2019-03-12 2021-07-13 Picodya Technologies Ltd. Sample analysis system and method
CA3146874A1 (en) * 2019-08-05 2021-02-11 Repligen Corporation Devices, systems, and methods for continuous processing with alternating tangential flow
EP4010481A4 (en) 2019-08-09 2023-09-20 Nutcracker Therapeutics, Inc. MICROFLUIDIC DEVICE AND METHODS OF USE
US10820847B1 (en) 2019-08-15 2020-11-03 Talis Biomedical Corporation Diagnostic system
JP6766309B1 (ja) 2019-09-10 2020-10-14 株式会社アペレ 血液凝固時間測定用カートリッジ及び血液凝固時間測定装置
CN110554184A (zh) * 2019-09-12 2019-12-10 深圳市科瑞达生物技术有限公司 一种化学发光微流控芯片
KR102271188B1 (ko) * 2019-12-13 2021-06-30 성균관대학교산학협력단 형광 이미징 기반 미생물 검출 장치 및 이의 제조방법
CN111214991A (zh) * 2020-01-13 2020-06-02 清华大学 一种高粘度液体常温自动混合装置
CN113275045A (zh) * 2020-02-20 2021-08-20 北京京东方健康科技有限公司 检测芯片及其操作方法、检测系统
CN111551752B (zh) * 2020-04-03 2021-10-08 深圳市科瑞达生物技术有限公司 一种化学发光免疫检测芯片及应用
CN111595836B (zh) * 2020-04-16 2022-09-30 四川轻化工大学 手持式气液相界面化学发光检测笔、装置、系统及其检测方法
CN116348583A (zh) * 2020-05-26 2023-06-27 川赛托斯有限责任公司 用于转染的装置和方法
EP4171813A1 (en) * 2020-06-26 2023-05-03 Swissmeca SA Microfluidic chip and pumping device
US20220062898A1 (en) * 2020-08-28 2022-03-03 Leica Microsystems Cms Gmbh Microfluidic Device for Image Multiplexing
GB2599357B (en) * 2020-09-21 2025-05-07 Quantumdx Group Ltd Microfluidic device with positive displacement pump
CN114113567A (zh) * 2020-11-26 2022-03-01 深圳市理邦精密仪器股份有限公司 分子诊断离心测试卡
CN112578111B (zh) * 2020-12-25 2024-06-18 扬州初心科技服务有限公司 一种食品抗生素蠕动多联免疫检测器
CN114763511B (zh) * 2021-01-14 2025-09-05 苏州思纳福医疗科技有限公司 物料转移机构、检测盒、核酸检测设备及物料转移方法
WO2022159570A1 (en) * 2021-01-21 2022-07-28 Group K Diagnostics, Inc. Microfluidic devices and rapid processing thereof
CN113063780B (zh) * 2021-03-17 2023-11-03 长春长光辰英生物科学仪器有限公司 一种用于光学检测的拭子样品流体系统及其使用方法
CN115703985A (zh) * 2021-08-06 2023-02-17 来富可得生物科技股份有限公司 微流道芯片及其使用方法
JP7784257B2 (ja) * 2021-09-14 2025-12-11 Nok株式会社 Ｐｃｒ用マイクロ流体チップおよびｐｃｒ分析装置
GB2611290A (en) * 2021-09-23 2023-04-05 Genome Res Ltd Flow cell interface adaptor
CN115791763B (zh) * 2022-10-20 2023-11-14 胜泰生科(广州)医疗科技有限公司 均相发光检测装置及应用
CN115931637A (zh) * 2022-12-12 2023-04-07 大连理工大学 一种测量脑脊液粘度的一体化微流控装置及方法
EP4389265A1 (en) * 2022-12-20 2024-06-26 1Drop Inc. Microfluidic device mounted with membrane filter with attached salt and apparatus for mounting membrane filter
CN116943497B (zh) * 2023-08-18 2025-12-09 江苏大学 一种心形函数结构的被动式微混合器
DE102023126574A1 (de) * 2023-09-28 2025-04-03 Bürkert Werke GmbH & Co. KG Mikrofluidische Vorrichtung, Proteindefektdiagnosevorrichtung mit mikrofluidischer Vorrichtung, Verfahren zum Konditionieren eines Sensorelements für Proteindefekterkennung sowie Verfahren zur Analyse von Proteindefekten
DE102023126568A1 (de) * 2023-09-28 2025-04-03 Bürkert Werke GmbH & Co. KG Mikrofluidische Vorrichtung, Proteindefektdiagnosevorrichtung mit mikrofluidischer Vorrichtung, Verfahren zum Blutprobenauftrag auf ein Sensorelement sowie Verfahren zur Analyse von Proteindefekten
DE102023126576A1 (de) * 2023-09-28 2025-04-03 Bürkert Werke GmbH & Co. KG Mikrofluidische Vorrichtung, Proteindefektdiagnosevorrichtung mit mikrofluidischer Vorrichtung, Verfahren für Proteindefektdiagnose sowie Verfahren zur Analyse von Proteindefekten
DE102023126573A1 (de) * 2023-09-28 2025-04-03 Bürkert Werke GmbH & Co. KG Einweg-Fluidführungsbaugruppe, Verfahren zur Herstellung der Einweg-Fluidführungsbaugruppe, mikrofluidische Vorrichtung mit Einweg-Fluidführungsbaugruppe sowie Proteindefektdiagnosevorrichtung
CN117625394B (zh) * 2023-12-01 2024-12-06 东莞合安机电有限公司 一种荔枝菌菌种培养液、制备方法及培养方法
WO2025226019A1 (ko) * 2024-04-23 2025-10-30 박용원 단백질반응장치 및 이를 포함하는 단백질검출시스템
CN119909778B (zh) * 2025-01-22 2025-11-04 北京工业大学 一种微流控芯片及其进行双气相自由基同时富集的方法
CN120028111B (zh) * 2025-04-22 2025-09-12 中国人民解放军北部战区总医院 一种自动化流式细胞染色装置

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20110041935A1 (en) 2004-10-13 2011-02-24 Rheonix, Inc. Microfluidic pump and valve structures and fabrication methods
WO2011123801A1 (en) 2010-04-02 2011-10-06 Integenx Inc. Fluidic article fabricated in one piece

Family Cites Families (54)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3996345A (en) 1974-08-12 1976-12-07 Syva Company Fluorescence quenching with immunological pairs in immunoassays
US4181650A (en) 1975-08-25 1980-01-01 Maier Charles L Jr Procedure for the assay of pharmacologically immunologically and biochemically active compounds in biological fluids
US4235960A (en) 1977-07-29 1980-11-25 The Medical College Of Wisconsin, Inc. Competitive enzyme-linked immunoassay
NL8000173A (nl) 1980-01-11 1981-08-03 Akzo Nv Toepassing van in water dispergeerbare, hydrofobe kleurstoffen als label in immunochemische testen.
US4366241A (en) 1980-08-07 1982-12-28 Syva Company Concentrating zone method in heterogeneous immunoassays
CA1291031C (en) 1985-12-23 1991-10-22 Nikolaas C.J. De Jaeger Method for the detection of specific binding agents and their correspondingbindable substances
US4810630A (en) 1987-03-30 1989-03-07 E. I. Du Pont De Nemours And Company Use of polyoxyethylene ethers to improve the performance of immunoassays employing peroxidase conjugates
US4849340A (en) 1987-04-03 1989-07-18 Cardiovascular Diagnostics, Inc. Reaction system element and method for performing prothrombin time assay
US5100626A (en) 1990-05-24 1992-03-31 Levin Andrew E Binding assay device with removable cassette and manifold
US5415994A (en) 1993-08-02 1995-05-16 Quidel Corporation Lateral flow medical diagnostic assay device with sample extraction means
DE4332720C2 (de) 1993-09-25 1997-02-13 Karlsruhe Forschzent Mikromembranpumpe
US6287850B1 (en) 1995-06-07 2001-09-11 Affymetrix, Inc. Bioarray chip reaction apparatus and its manufacture
US5639428A (en) 1994-07-19 1997-06-17 Becton Dickinson And Company Method and apparatus for fully automated nucleic acid amplification, nucleic acid assay and immunoassay
SE504193C2 (sv) 1995-04-21 1996-12-02 Hemocue Ab Kapillär mikrokyvett
US5856174A (en) 1995-06-29 1999-01-05 Affymetrix, Inc. Integrated nucleic acid diagnostic device
US6541213B1 (en) 1996-03-29 2003-04-01 University Of Washington Microscale diffusion immunoassay
US7052594B2 (en) 2002-01-31 2006-05-30 Sri International Devices and methods for controlling fluid flow using elastic sheet deflection
US6303389B1 (en) 1997-06-27 2001-10-16 Immunetics Rapid flow-through binding assay apparatus and method therefor
US6037168A (en) 1997-12-31 2000-03-14 Cytonix Corporation Microbiological assembly comprising resealable closure means
SE9800070D0 (sv) 1998-01-14 1998-01-14 Hemocue Ab Blandningsmetod
US6158712A (en) 1998-10-16 2000-12-12 Agilent Technologies, Inc. Multilayer integrated assembly having an integral microminiature valve
US6673620B1 (en) 1999-04-20 2004-01-06 Cytologix Corporation Fluid exchange in a chamber on a microscope slide
AU4242600A (en) * 1999-04-20 2000-11-02 Cytologix Corporation Fluid exchange in a chamber on a microscope slide
US6743399B1 (en) 1999-10-08 2004-06-01 Micronics, Inc. Pumpless microfluidics
US6272939B1 (en) 1999-10-15 2001-08-14 Applera Corporation System and method for filling a substrate with a liquid sample
US6569674B1 (en) 1999-12-15 2003-05-27 Amersham Biosciences Ab Method and apparatus for performing biological reactions on a substrate surface
US6309875B1 (en) 2000-02-29 2001-10-30 Agilent Technologies, Inc. Apparatus for biomolecular array hybridization facilitated by agitation during centrifuging
WO2001068238A2 (en) 2000-03-14 2001-09-20 Micronics, Inc. Microfluidic analysis cartridge
AU2001250929A1 (en) 2000-03-21 2001-10-03 Covaris, Inc. Method and apparatus for acoustically controlling liquid solutions in microfluidic devices
US6431212B1 (en) 2000-05-24 2002-08-13 Jon W. Hayenga Valve for use in microfluidic structures
US20020015959A1 (en) 2000-06-23 2002-02-07 Bardell Ronald L. Fluid mixing in microfluidic structures
ES2232407T3 (es) 2000-12-28 2005-06-01 F. Hoffmann-La Roche Ag Metodo para el procesado de una muestra de acido nucleico mediante la oscilacion de un segmento de una pared de un cartucho, un sistema y un cartucho para realizar dicho metodo.
US7223363B2 (en) 2001-03-09 2007-05-29 Biomicro Systems, Inc. Method and system for microfluidic interfacing to arrays
WO2003015923A1 (en) 2001-08-20 2003-02-27 Biomicro Systems, Inc. Fluid mixing in low aspect ratio chambers
EP1377821A2 (en) 2001-04-03 2004-01-07 Micronics, Inc. Pneumatic valve interface for use in microfluidic structures
DE50212817D1 (de) * 2001-05-25 2008-11-06 Tecan Trading Ag Vorrichtung und Verfahrenseinheit zum Bereitstellen eines Hybridisierraums
US6729352B2 (en) 2001-06-07 2004-05-04 Nanostream, Inc. Microfluidic synthesis devices and methods
US6773677B2 (en) * 2002-01-09 2004-08-10 Caliper Life Sciences, Inc. Slide cassette for fluidic injection
US7223371B2 (en) 2002-03-14 2007-05-29 Micronics, Inc. Microfluidic channel network device
US6843263B2 (en) 2002-06-24 2005-01-18 Industrial Technology Research Institute Partially closed microfluidic system and microfluidic driving method
US7419638B2 (en) 2003-01-14 2008-09-02 Micronics, Inc. Microfluidic devices for fluid manipulation and analysis
EP1592505A2 (en) 2003-01-21 2005-11-09 Micronics, Inc. Method and system for microfluidic manipulation, amplification and analysis of fluids, for example, bacteria assays and antiglobulin testing
US6916113B2 (en) 2003-05-16 2005-07-12 Agilent Technologies, Inc. Devices and methods for fluid mixing
DE10336849A1 (de) * 2003-08-11 2005-03-10 Thinxxs Gmbh Flusszelle
DE10352716A1 (de) * 2003-11-05 2005-06-16 Einsle, Xaver Plattform
CA2563613A1 (en) * 2004-04-16 2005-12-08 Wei-Sing Chu Device for extracting biological molecules from tissue specimens
EP1614466A3 (de) * 2004-07-08 2006-05-10 Tecan Trading AG System mit Einrichtung zum Verhindern von Luftblasen in einer Hybridisierkammer und entsprechendes Verfahren
US20060127886A1 (en) 2004-12-15 2006-06-15 Kaylor Rosann M Sample-efficient lateral flow immunoassay
WO2008002462A2 (en) * 2006-06-23 2008-01-03 Micronics, Inc. Methods and devices for microfluidic point-of-care immunoassays
US7763453B2 (en) 2005-11-30 2010-07-27 Micronics, Inc. Microfluidic mixing and analytic apparatus
US7906317B2 (en) 2007-10-21 2011-03-15 King Car Food Industrial Co., Ltd. Apparatus for thin-layer cell smear preparation and in-situ hybridization
ATE485101T1 (de) * 2008-06-02 2010-11-15 Boehringer Ingelheim Micropart Mikrofluidische folienstruktur zum dosierren von flüssigkeiten
JP2010078508A (ja) * 2008-09-26 2010-04-08 Toshiba Corp 送液装置
WO2010040103A1 (en) 2008-10-03 2010-04-08 Micronics, Inc. Microfluidic apparatus and methods for performing blood typing and crossmatching

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20110041935A1 (en) 2004-10-13 2011-02-24 Rheonix, Inc. Microfluidic pump and valve structures and fabrication methods
WO2011123801A1 (en) 2010-04-02 2011-10-06 Integenx Inc. Fluidic article fabricated in one piece

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