KR102067394B1 - 신경학적 염증성 장애의 치료를 위한 인자 ｘｉｉ 억제제 - Google Patents
신경학적 염증성 장애의 치료를 위한 인자 ｘｉｉ 억제제 Download PDFInfo
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- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/36—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against blood coagulation factors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Epidemiology (AREA)
- Gastroenterology & Hepatology (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
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- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Zoology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Hematology (AREA)
- Mycology (AREA)
- Cell Biology (AREA)
- Vascular Medicine (AREA)
- Microbiology (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
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Applications Claiming Priority (5)
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| US201261592652P | 2012-01-31 | 2012-01-31 | |
| US61/592,652 | 2012-01-31 | ||
| EP12153341.8A EP2623110A1 (en) | 2012-01-31 | 2012-01-31 | Factor XII inhibitors for the treatment of neurological inflammatory disorders |
| EP12153341.8 | 2012-01-31 | ||
| PCT/EP2013/051832 WO2013113774A1 (en) | 2012-01-31 | 2013-01-31 | Factor xii inhibitors for the treatment of neurological inflammatory disorders |
Publications (2)
| Publication Number | Publication Date |
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| KR20140117660A KR20140117660A (ko) | 2014-10-07 |
| KR102067394B1 true KR102067394B1 (ko) | 2020-01-17 |
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| EP (2) | EP2623110A1 (enExample) |
| JP (1) | JP6243854B2 (enExample) |
| KR (1) | KR102067394B1 (enExample) |
| CN (1) | CN104080470B (enExample) |
| AU (1) | AU2013200498B2 (enExample) |
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| ES (1) | ES2687018T3 (enExample) |
| PL (1) | PL2809336T3 (enExample) |
| WO (1) | WO2013113774A1 (enExample) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
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| EP2683397B1 (en) | 2011-03-09 | 2017-08-09 | CSL Behring GmbH | Factor xii inhibitors for the administration with medical procedures comprising contact with artificial surfaces |
| AU2014224599B2 (en) | 2013-03-08 | 2018-11-08 | Csl Behring Gmbh | Treatment and prevention of remote ischemia-reperfusion injury |
| CA2930544A1 (en) | 2013-11-13 | 2015-05-21 | Shire Viropharma Incorporated | Uses of c1-esterase inhibitor for the treatment of neuromyelitis optic a and neuromyelitis optica spectrum disorders and compositions comprising same |
| US20170114119A1 (en) * | 2014-06-18 | 2017-04-27 | Csl Behring Gmbh | Therapy using a factor xii inhibitor in a neurotraumatic disorder |
| US20160130324A1 (en) * | 2014-10-31 | 2016-05-12 | Shire Human Genetic Therapies, Inc. | C1 Inhibitor Fusion Proteins and Uses Thereof |
| KR101744959B1 (ko) * | 2014-12-05 | 2017-06-12 | (주)케어젠 | 피부상태 개선 활성을 갖는 펩타이드 및 이의 용도 |
| CA2972800A1 (en) * | 2015-01-02 | 2016-07-07 | Dyax Corp. | Bispecific antibodies against plasma kallikrein and factor xii |
| JPWO2016114386A1 (ja) * | 2015-01-15 | 2017-10-19 | 国立研究開発法人国立精神・神経医療研究センター | 進行型免疫性脱髄疾患治療剤 |
| US10913802B2 (en) | 2015-07-21 | 2021-02-09 | Dyax Corp. | Monoclonal antibody inhibitor of factor XIIA |
| MA43660A (fr) | 2016-01-22 | 2018-11-28 | Adimab Llc | Anticorps anti-facteur xi de coagulation |
| CA3019851A1 (en) * | 2016-04-06 | 2017-10-12 | Csl Limited | Method of treating atherosclerosis |
| US20190175683A1 (en) | 2016-08-05 | 2019-06-13 | Csl Behring Gmbh | Pharmaceutical formulations of c1 esterase inhibitor |
| AU2018270396B2 (en) | 2017-05-15 | 2025-03-20 | Stem Cell Medicine Ltd. | Treatment of multiple sclerosis with adipose-derived stem cells |
| WO2018211486A1 (en) | 2017-05-15 | 2018-11-22 | Stem Cell Medicine Ltd. | Treatment of multiple sclerosis with long acting glatiramer and adipose-derived stem cells |
| JP7317827B2 (ja) * | 2017-12-15 | 2023-07-31 | シーエスエル、リミテッド | 腎線維症および／または慢性腎臓疾患の治療におけるＦＸＩＩａインヒビターの使用 |
| EA202190056A1 (ru) | 2018-06-19 | 2021-05-28 | Ридженерон Фармасьютикалз, Инк. | АНТИТЕЛА ПРОТИВ ФАКТОРА XII/XIIa И ИХ ПРИМЕНЕНИЕ |
| US20240352150A2 (en) * | 2020-06-16 | 2024-10-24 | Ningbo Comgen Biotech Co., Ltd. | Anti-factor xii (fxii) nanobody or antigen-binding fragment thereof, and use thereof |
| WO2025019789A1 (en) | 2023-07-19 | 2025-01-23 | Regeneron Pharmaceuticals, Inc. | ANTI-FACTOR XII/XIIa ANTIBODIES AND USES THEREOF |
| CN120192392B (zh) * | 2025-05-23 | 2025-09-05 | 昆明医科大学 | 一种版纳绳蚋抗栓肽Sibakazin及其应用 |
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| WO2006066878A1 (en) | 2004-12-23 | 2006-06-29 | Csl Behring Gmbh | Prevention of thrombus formation and/or stabilization |
| WO2008098720A1 (en) | 2007-02-12 | 2008-08-21 | Csl Behring Gmbh | Therapeutic application of kazal-type serine protease inhibitors |
| US20100143344A1 (en) | 2006-10-10 | 2010-06-10 | Academisch Ziekenhuis Bij De Universiteit Van Amsterdam | Complement inhibition for improved nerve regeneration |
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| EP0154316B1 (en) | 1984-03-06 | 1989-09-13 | Takeda Chemical Industries, Ltd. | Chemically modified lymphokine and production thereof |
| US4963657A (en) | 1988-06-09 | 1990-10-16 | Temple University Of The Commonwealth System Of Higher Education | Monoclonal antibodies to the light chain region of human factor XII and methods of preparing and using the same |
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| US5252714A (en) | 1990-11-28 | 1993-10-12 | The University Of Alabama In Huntsville | Preparation and use of polyethylene glycol propionaldehyde |
| CA2106079C (en) | 1991-03-15 | 2000-04-25 | Robert C. Thompson | Pegylation of polypeptides |
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| ZA963619B (en) | 1995-05-08 | 1996-11-22 | Scios Inc | Protease inhibitor peptides |
| GB9800817D0 (en) * | 1998-01-16 | 1998-03-11 | Bio Discovery Ltd | Serine protease inhibitors |
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| ES2649037T3 (es) | 2000-12-12 | 2018-01-09 | Medimmune, Llc | Moléculas con semividas prolongadas, composiciones y usos de las mismas |
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| ATE525395T1 (de) | 2003-06-12 | 2011-10-15 | Lilly Co Eli | Fusions proteine von glp-1-analoga |
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| KR20060124656A (ko) | 2003-12-31 | 2006-12-05 | 메르크 파텐트 게엠베하 | 개선된 약물동태를 가지는 Ｆｃ-에리스로포이에틴 융합단백질 |
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| US20070135620A1 (en) | 2004-11-12 | 2007-06-14 | Xencor, Inc. | Fc variants with altered binding to FcRn |
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| CA2750533A1 (en) | 2009-01-23 | 2010-07-29 | Biogen Idec Ma Inc. | Stabilized fc polypeptides with reduced effector function and methods of use |
| CA2841185C (en) | 2011-07-22 | 2021-05-25 | Csl Behring Gmbh | Inhibitory anti -factor xii/xiia monoclonal antibodies and their uses |
-
2012
- 2012-01-31 EP EP12153341.8A patent/EP2623110A1/en not_active Ceased
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2013
- 2013-01-31 AU AU2013200498A patent/AU2013200498B2/en active Active
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- 2013-01-31 PL PL13701651T patent/PL2809336T3/pl unknown
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2006066878A1 (en) | 2004-12-23 | 2006-06-29 | Csl Behring Gmbh | Prevention of thrombus formation and/or stabilization |
| US20100143344A1 (en) | 2006-10-10 | 2010-06-10 | Academisch Ziekenhuis Bij De Universiteit Van Amsterdam | Complement inhibition for improved nerve regeneration |
| WO2008098720A1 (en) | 2007-02-12 | 2008-08-21 | Csl Behring Gmbh | Therapeutic application of kazal-type serine protease inhibitors |
Also Published As
| Publication number | Publication date |
|---|---|
| JP6243854B2 (ja) | 2017-12-06 |
| AU2013200498A1 (en) | 2013-08-15 |
| CN104080470B (zh) | 2017-04-19 |
| EP2809336A1 (en) | 2014-12-10 |
| ES2687018T3 (es) | 2018-10-23 |
| US20140378653A1 (en) | 2014-12-25 |
| WO2013113774A1 (en) | 2013-08-08 |
| EP2623110A1 (en) | 2013-08-07 |
| PL2809336T3 (pl) | 2018-11-30 |
| AU2013200498B2 (en) | 2015-05-07 |
| CA2862903C (en) | 2021-07-13 |
| JP2015511221A (ja) | 2015-04-16 |
| DK2809336T3 (en) | 2018-09-17 |
| HK1201728A1 (en) | 2015-09-11 |
| US9957329B2 (en) | 2018-05-01 |
| CA2862903A1 (en) | 2013-08-08 |
| EP2809336B1 (en) | 2018-06-20 |
| KR20140117660A (ko) | 2014-10-07 |
| CN104080470A (zh) | 2014-10-01 |
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