KR102055150B1 - Intercellular Lipids Mimetic Composition with Improved Transdermal Absorption, Method for Preparing Same, and Hydrogel Mask Pack Containing Same - Google Patents

Abstract

The present invention relates to an intercellular lipid mimetic composition for a mask pack, a preparation method thereof, and a hydrogel mask pack containing the same, and more specifically, to an intercellular lipid mimetic composition for a mask pack, to which water, oil, a polyvalent alcohol, a gelation polymer, a skin active ingredient, and a naturally derived intercellular lipid mimic are applied; a preparation method thereof; and a hydrogel mask pack containing the same. The intercellular lipid mimetic composition according to the present invention has an excellent ability of delivering functional ingredients effective in the skin to sclerite for the purposes of whitening and wrinkle alleviation since the intercellular lipid mimetic composition has a high physiochemical similarity to an extracellular matrix, thereby having excellent biocompatibility. Therefore, the hydrogel mask pack containing the intercellular lipid mimetic composition reinforces skin barrier by having a higher moisturizing power than a general hydrogel, suppresses water evaporation by exhibiting a shielding effect, and can further improve effects of the skin active ingredients by stably delivering skin active ingredients to the skin for a long period of time.

Description

Intercellular Lipids Mimetic Composition with Improved Transdermal Absorption, Method for Preparing Same, and Hydrogel Mask Pack Containing Same}

The present invention relates to an intercellular lipid mimetic composition for a mask pack, a method for preparing the same, and a hydrogel mask pack containing the same, and more specifically, the ability to deliver efficacies such as moisturizing, whitening, and wrinkle improvement to the dermal transdermal skin. It relates to an intercellular lipid mimetic composition for a mask pack having an excellent lamellar structure, a preparation method thereof, and a hydrogel mask pack containing the same.

Among various cosmetic items, the mask pack can be used all four seasons, and it has been showing high growth rate due to its superior convenience and immediate effect compared to the cost ratio. These mask packs are introduced in various types of products according to the needs of consumers. Among the mask mask packs in which the skin support is impregnated with the cosmetics, the usability is simple, but the impregnated contents are inconvenient to flow down, and the adhesion strength varies depending on the type of the support, and thus it is difficult to be fixed to the face as a whole. . As a result of improving the adhesion, the biocellulose mask pack developed using the microbial fermentation process has excellent skin adhesion, but has a high drying speed after use, rather than taking away moisture in the skin and causing dryness.

On the contrary, hydrogel mask packs have excellent skin adhesion, so that the hydrogel mask pack may gradually release the moisture contained in the gel due to the shielding effect to supply moisture to the skin for a long time. In addition, it is a product designed to continuously deliver the efficacy and effect by supporting the active ingredient inside the water-soluble polymer structure constituting the hydrogel.

In addition, interest in cosmeceutical has recently increased. This is a compound word of cosmetic and pharmaceutical, and it means cosmetics containing medically proven functional ingredients such as whitening, wrinkle improvement and skin regeneration. Accordingly, active researches on methods of enhancing percutaneous absorption of functional active ingredients and active ingredients and formulations containing them are being actively conducted, and finding ways to maximize the efficacy desired by consumers by selectively absorbing active ingredients into the skin. It is important.

On the other hand, as one of the above methods in the field of cosmetics, research using the liquid crystal of the lamellar structure that implements the intercellular lipid structure in the stratum corneum is increasing trend. Liquid crystal is a term meaning an intermediate state between a solid and a liquid, and generally refers to a system in which a plurality of layers of lamellar structures are formed by uniformly arranging organic molecules having both hydrophilic and lipophilic parts. do. Emulsions using liquid crystals are being used as a formulation to increase the stability of the product and to carry the active ingredient inside the cosmetic composition.

As an example of applying such a liquid crystal emulsifier to a mask pack, the Republic of Korea Patent Publication No. 10-2006-0018493 has provided a semi-transparent gel mask cosmetic composition using the liquid crystal emulsification method, the latest patent is the Republic of Korea Patent Publication No. 10 -2017-0125211 discloses a hydrogel mask pack composition having excellent water retention.

In general, the selection of an optimized emulsifier is important in order to form an intercellular lipid mimetic (liquid crystal emulsion), and conventionally mainly used cholesterol, lecithin and the like. However, this is highly dependent on imports and different from the composition ratio of the skin lipid structure, so that the affinity of the skin is low and the long-term stability of the formulation is unstable.

Therefore, in order to develop an intercellular lipid mimetic, which is a liquid lamella emulsion having a lamellar structure most similar to the intercellular lipid structure in the stratum corneum of the skin, it is important to develop an optimized emulsifier that has excellent stability and can significantly increase the transdermal absorption rate of the active ingredient.

In order to solve this problem, the inventors of the present invention have developed an emulsifier combining natural polysaccharides, ceramides, lecithins, etc. in the most optimal composition ratio, and implement an intercellular lipid mimetic of a lamellar structure for a mask pack using the same. To this end, natural-derived polymers were applied to form hydrogels and then mask packs to provide excellent moisturizing power due to the high water content of the existing hydrogel masks and to stably support the skin's active ingredients of the intercellular lipid mimetics. It is an optimized TDDS (Transderma Drug Delivery System) formulation with the benefits of improving the skin's ability to effectively deliver effective ingredients into the skin, unlike conventional mask packs, and improves skin's functions such as whitening and wrinkle improvement. This excellent mask pack was developed and completed.

It is an object of the present invention to provide an intercellular lipid mimetic composition for a mask pack having enhanced transdermal absorption ability.

Still another object of the present invention is to provide a method for preparing the intercellular lipid mimetic composition for the mask pack.

Still another object of the present invention is to provide a hydrogel mask pack to which the intercellular lipid mimetic composition for the mask pack is applied.

Still another object of the present invention is to provide a method for preparing a hydrogel mask pack to which the intercellular lipid mimetic composition for the mask pack is applied.

In order to achieve the above object, the present invention provides an intercellular lipid lipid mimetic composition for a mask pack containing an emulsifier, an aqueous phase component, an oil phase component and a gelling polymer comprising a sucrose-based compound, a lecithin-based compound and a ceramide-based compound. .

In the present invention, the sucrose-based compound is sucrose distearate, sucrose dilaurate, sucrose stearate, sucrose myristate ( sucrose myristate, sucrose laurate and sucrose palmitate may be one or more selected from the group consisting of.

In the present invention, the lecithin-based compound may be at least one of lecithin and hydrogenated lecithin.

In the present invention, the ceramide-based compound is in the group consisting of Ceramide EOP (Ceramide EOP), Ceramide NS (Ceramide NS), Ceramide NP, Ceramide AS (Ceramide AS) and Ceramide AP (Ceramide AP) It may be one or more selected.

In the present invention, the emulsifier may include 50 to 70% by weight of sucrose-based compound, 20 to 40% by weight of lecithin-based compound and 5 to 15% by weight of ceramide-based compound based on the total weight of the emulsifier.

The intercellular lipid lipid mimetic composition for a mask pack of the present invention preferably contains 0.5 to 5% by weight based on the total weight of the total composition.

In the present invention, the aqueous phase component may include water, a polyhydric alcohol, and a water-soluble polymer.

In the present invention, the polyhydric alcohol is glycerin (glycerin), 1,3-butylene glycol (1,3-butylene glycol), dipropylene glycol (dipropylene glycol), 1,2-hexanediol (1, 2-hexanediol), propanediol (propanediol), methyl propanediol (methyl propanediol), diglycerin (diclycerin) and ethylene glycol (ethylene glycol) may be one or more selected from the group consisting of.

In the present invention, the water-soluble polymer is xanthan gum (xanthan gum), carboxymethylcellulose (carboxymethylcellulose), hydroxyethyl cellulose (carboxyethylcellulose), polyacrylate (polyacrylate), sodium polyacrylate (sodium polyacrylate), carboxyvinyl polymer ( carboxyvinyl polymer, polyvinyl alcohol, polyacrylamide, polyethyleneoxide, polyethyleneimine, polyvinyl pyrrolidone, hydroxyethyl acrylate / sodium acryl Hydroxyethyl acrylate / sodium acryloyldimethyltaurate copolymer, acrylate / C10-30 alkylacrylate crosspolymer, and ammonium acryloyldimethyltaurate / Behenes -25 methacrylate crosspolymer (ammoniumacryloyl dimethyltaurate / beheneth-25 meth acrylate crosspolymer) may be one or more selected from the group consisting of.

The intercellular lipid lipid mimetic composition for a mask pack of the present invention preferably contains 64 to 95% by weight of the aqueous phase component based on the total weight of the total composition.

In the present invention, the oily component may include oil, wax and higher alcohol.

In the present invention, the oil is ethylhexyl palmitate, isopropyl myristate, ethyl laurate, ethyl myristate, ethyl myristate, isopropyl palmitate, Cyclopentane, cyclooctane, caprylic / capric triglyceride, butyleneglycol dicaprylate / dicaprate, triethylhexa Triethylhexanoin, pentaerythrityl tetrathylhexanoate, cetyl ethylhexanoate, isopropyl myristate, octyldodecanol, mineral oil ), Vaseline, hydrogenated polydecene, squalene, squalane, squajo Jojoba oil, avocado oil, macadamia nut oil, coconut oil, olive oil, argan oil, hawthorn oil, argan tree kernel oil group consisting of oil, lavender oil, meadow foam seed oil, cyclomethicone, phenyltrimethicone, cyclopentasiloxane and dimethicone It may be at least one selected from.

In the present invention, the wax is at least one selected from the group consisting of carnauba wax, candelilla wax, bees wax, lanolin and microstalin wax. Can be.

In the present invention, the higher alcohol is a group consisting of lauryl alcohol (lauryl alcohol), cetyl alcohol (cetyl alcohol), stearyl alcohol (stearyl alcohol), cetearyl alcohol (cetearyl alcohol) and behenyl alcohol (behenyl alcohol) It may be at least one selected from.

The intercellular lipid lipid mimetic composition for a mask pack of the present invention preferably contains 2 to 10% by weight of the oily component, based on the total weight of the total composition.

In the present invention, the gelling polymer is glucomannan, guamo gum (cyamopsis tetragonoloba (guar gum), carob gum (ceratonia siliqua (carob) gum), agar (agar), carrageenan (carrageenan), Irish moss powder ( chondrus crispus powder, xanthan gum, gellan gum, cellulose gum, konjac, chitosan, starch, pectin, pullulan ), Tamarindus indica seed gum and agar may be one or more selected from the group consisting of agar.

The intercellular lipid lipid mimetic composition for a mask pack of the present invention preferably contains 0.1 to 10% by weight of the gelling polymer based on the total weight of the total composition.

The intercellular lipid mimetic composition for mask pack of the present invention is glyceryl stearate, polyglyceryl-3methylglucose distearate, polysorbate 60, cetearyl Glucoside (cetearyl glucoside), cetearyl olivate, sorbitan olivate, PIG-100 stearate, PIG-60 hydrogenated castor oil (PEG- It may further comprise one or more auxiliary emulsifiers selected from the group consisting of 60 hydrogenated castor oil) and sorbitan sesquioleate.

In the present invention, the auxiliary emulsifier may be included in 0.1 to 1% by weight based on the total composition.

The intercellular lipid lipid mimetic composition for a mask pack of the present invention may also include madecassoside, allantoin, panthenol, betaine, retinol and retinyl palmitate. Retinyl acetate, coenzyme Q-10, elastin, collagen, hyaluronic acid, ascorbic acid, ascorbyl glucoside ), Alpha-bisabolol, tocopherol, tocopherol acetate, tocopherol acetate, albutin, niacinamide, tranexanic acid adenosine, retinol acetate (retinol acetate), amino acids, mineral water, sodium hyaluronate and at least one skin active ingredient selected from the group consisting of plant extracts Can be.

In the present invention, the skin active ingredient may be included in an amount of 0.01 to 10% by weight based on the total composition.

The intercellular lipid mimetic composition according to the present invention is in the range of pH 4 to 8, and may have a viscosity of 500 to 5,000 cps.

The present invention also provides a method for preparing an intercellular lipid lipid mimetic composition for a mask pack, comprising the following steps:

(a) mixing the aqueous phase component and heating to 75-80 ° C. to dissolve it;

(b) mixing the oil phase component, the emulsifier and the auxiliary emulsifier and then dissolving by heating to 75 to 80 ° C;

(c) adding a lysate of the oil phase component, emulsifier and auxiliary emulsifier to the aqueous phase component and then stirring to form a mixture; And

(d) dispersing the gelling polymer in a polyhydric alcohol and then adding to the mixture and stirring while maintaining at 70 to 85 ℃.

The method of the present invention may further comprise, after step (d), adding (e) the skin active ingredient while maintaining the mixture at 70 to 85 ° C.

The present invention also provides a hydrogel mask pack including the intercellular lipid lipid mimetic composition for a mask pack prepared by the above method.

The present invention also comprises the steps of coating the support for the mask pack intercellular lipid mimetic composition at 70 to 85 ℃; And it provides a method for producing a hydrogel mask pack comprising the step of forming a composition-coated support after cooling to room temperature.

The present invention also comprises the steps of casting the intracellular lipid lipid mimetic composition for the mask pack in a mold; And cooling to room temperature provides a method for producing a hydrogel mask pack comprising the step of separating the solidified mask pack from the mold.

The intercellular lipid mimetics for mask packs according to the present invention have high physicochemical similarities with extracellular matrix and have excellent biocompatibility, and thus have an excellent ability to deliver functional ingredients effective to the skin such as whitening and wrinkle improvement to the transdermal. Therefore, the hydrogel mask pack containing the intercellular lipid capillary body has a higher moisturizing power than a normal hydrogel, inhibits moisture evaporation due to a shielding effect as well as strengthens the skin barrier, and delivers the active ingredients to the skin stably for a long time. By doing so, the effect can be improved more.

1 is an external appearance image of a hydrogel mask pack containing the intercellular lipid lipid mimetic composition of the present invention.
Figure 2 is an image of the particles of the intercellular lipid mimetic composition prepared in one embodiment of the present invention observed with a 400x polarization microscope.
Figure 3 is an image observed with a 400x polarization microscope of the particles before and after the 3-month harsh test of the intercellular lipid mimetic composition prepared in one embodiment of the present invention.

Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. In general, the nomenclature used herein is well known and commonly used in the art.

The interstitial lipid mimetic for the mask pack according to the present invention has a good lamella structure similar to that of the skin, and thus the skin affinity can be easily and quickly delivered to the skin. Furthermore, the hydrogel to which the intercellular lipid mimetics according to the present invention is applied is harmless to the skin and can strengthen the skin barrier by continuously delivering moisture and active ingredients.

The intercellular lipid capillary for the mask pack of the present invention includes an emulsifier, an aqueous phase component, an oil phase component, and a gelling polymer, and may further include an auxiliary emulsifier, and may further include an active skin component.

In the present invention, the intercellular lipid mimetic composition is 0.5 to 5% by weight emulsifier, 64 to 95% by weight aqueous phase component, 2 to 10% by weight oil phase component, 0.1 to 10% by weight gelling polymer, 0.1 to 1% by weight emulsifier % And 0.01 to 10% by weight of the skin active ingredient.

In the present invention, the emulsifier may include a sucrose-based compound, a lecithin-based compound and a ceramide-based compound. In one embodiment of the present invention, when preparing a composition for a mask pack using an emulsifier comprising a sucrose-based compound, a lecithin-based compound and a ceramide-based compound, intercellular paper having a significantly higher transdermal absorption rate than when using a liquid crystal emulsifier of the prior art It was confirmed that vaginal mimetic compositions can be prepared.

The sucrose-based compound is sucrose distearate, sucrose dilaurate, sucrose stearate, sucrose myristate, sucrose It is preferably at least one selected from the group consisting of sucrose laurate and sucrose palmitate, and in order to achieve the object of the present invention, the sucrose-based compound is sucrose die Stearate is most preferred.

The lecithin-based compound is preferably at least one of lecithin and hydrogenated lecithin, and most preferably hydrogenated lecithin.

The ceramide compound is at least one selected from the group consisting of Ceramide EOP, Ceramide NS, Ceramide NP, Ceramide AS, and Ceramide AP. Preferred, most preferred is Ceramide NP.

In the present invention, the sucrose-based compound is preferably included in 50 to 70% by weight relative to the total weight of the emulsifier.

In addition, the lecithin-based compound is preferably contained 20 to 40% by weight based on the total weight of the emulsifier.

In addition, the ceramide-based compound is preferably contained 5 to 15% by weight based on the total weight of the emulsifier.

The sucrose-based compound, the lecithin-based compound and the ceramid compound are preferably used in a weight ratio of 60:30:10.

The emulsifier is preferably included 1 to 5% by weight based on the total weight of the total composition. Outside the above range there is a problem that the lamellar structure is not well formed in the composition. In one embodiment of the present invention, when the liquid crystal emulsifier is used in less than 1% by weight or more than 5% by weight it was confirmed experimentally that the lamellar structure is not well formed, the stability is incomplete.

In the present invention, the aqueous phase component may include water, a polyhydric alcohol, and a water-soluble polymer. It is preferable to use purified water for the said water.

The water phase component is preferably included from 64 to 95% by weight based on the total weight of the total composition.

The polyhydric alcohol is glycerin (glycerin), 1,3-butylene glycol (1,3-butylene glycol), dipropylene glycol (dipropylene glycol), 1,2-hexanediol (1,2-hexanediol) At least one selected from the group consisting of propanediol, propanediol, methyl propanediol, diglycerin and ethylene glycol is preferred.

The polyhydric alcohol is preferably included 5 to 35% by weight based on the total weight of the total composition. If it is less than 5% by weight, it is difficult to disperse the gelling polymer or easily evaporate moisture when attached to the skin, and the adhesion may be lowered.When it exceeds 35% by weight, the strength of the gel decreases over time and it is applied to the skin. May cause excessive stickiness.

The water-soluble polymer is xanthan gum, carboxymethyl cellulose, hydroxyethyl cellulose, polyacrylate, sodium polyacrylate, carboxyvinyl polymer ), Polyvinyl alcohol, polyacrylamide, polyethyleneoxide, polyethyleneimine, polyvinyl pyrrolidone, hydroxyethyl acrylate / sodium acryloyl Hydroxyethyl acrylate / sodium acryloyldimethyltaurate copolymer, acrylate / C10-30 alkylacrylate crosspolymer, and ammonium acryloyldimethyltaurate / behenes-25 Methacrylate crosspolymer (ammoniumacryloyl dimethyltaurate / beheneth-25 methacrylate crosspoly mer) may be one or more selected from the group consisting of.

The water-soluble polymer can be more stable to form a lamellar structure formed of an emulsifier can improve the long-term formulation stability and effectively maintain moisture.

The water-soluble polymer is preferably added in 0.01 to 5% by weight based on the total weight of the total composition. If the water-soluble polymer is added in an excessive amount, it is difficult to maintain the shape of the liquid crystal particles and there is a problem of inferior elasticity.

In the present invention, the oil phase component may include oil, wax and higher alcohol.

The oil may be an ester oil, a hydrocarbon oil, a silicone oil, a natural oil, and the like, for example, ethylhexyl palmitate, isopropyl myristate, ethyl laurate ), Ethyl myristate, isopropyl palmitate, cyclopentane, cyclooctane, caprylic / capric triglyceride, butylenegly Butyleneglycol dicaprylate / dicaprate, triethylhexanoin, pentaerythrityl tetrathylhexanoate, cetylethylhexanoate, isopropyl myri Isopropyl myristate, octyldodecanol, mineral oil, vaseline, hydro Hydrogenated polydecene, squalene, squalene, squalane, jojoba oil, avocado oil, macadamia nut oil, coconut oil, olive oil Oils, argan oil, hawthorn oil, argania spinosa kernel oil, lavender oil, meadowfoam seed oil, cyclomethicone, phenyltrimethicone (phenyltrimethicone), cyclopentasiloxane (cyclopentasiloxane) and dimethicone (dimethicone) may be one or more selected from the group consisting of.

The oil may be included in an amount of 1 to 10% by weight based on the total weight of the total composition.

The wax is preferably one or more selected from the group consisting of carnauba wax, candelilla wax, bees wax, lanolin and microstalin wax.

The wax is preferably included 0.5 to 5% by weight based on the total weight of the total composition.

In the present invention, the higher alcohol is a group consisting of lauryl alcohol (lauryl alcohol), cetyl alcohol (cetyl alcohol), stearyl alcohol (stearyl alcohol), cetearyl alcohol (cetearyl alcohol) and behenyl alcohol (behenyl alcohol) At least one selected from is preferred.

The higher alcohol is preferably included 0.5 to 5% by weight based on the total weight of the total composition.

The oil phase component is preferably contained 2 to 10% by weight based on the total weight of the total composition. When used at less than 2% by weight, it is difficult to form a lamellar structure, and thus the percutaneous absorption rate of the active ingredient of the skin tends to be lowered, and when it exceeds 10% by weight, it is separated from the water phase and the formulation stability is lowered to prepare the final mask pack. There is a difficult problem.

In the present invention, the gelling polymer is glucomannan, guamo gum (cyamopsis tetragonoloba (guar gum), carob gum (ceratonia siliqua (carob) gum), agar (agar), carrageenan (carrageenan), Irish moss powder ( chondrus crispus powder, xanthan gum and gellan gum, cellulose gum, konjac, chitosan, starch, pectin, pullulan ), Tamarindus indica seed gum and agar may be one or more selected from the group consisting of agar.

The gelling polymer is preferably included 0.1 to 10% by weight based on the total weight of the total composition. When used in less than 0.1% by weight, the shape of the gel can be maintained, but the strength of the gel is low and the flexibility is low, resulting in poor adhesion to the skin, and in the case of more than 10% by weight, the gel is stretched, making it difficult to maintain the shape and elasticity, making it difficult to manufacture. There is a problem.

In the present invention, the auxiliary emulsifier is glyceryl stearate, polyglyceryl-3methylglucose distearate, polysorbate 60, cetearyl glucoside ), Cetearyl olivate, sorbitan olivate, PIG-100 stearate, PIG-60 hydrogenated castor oil And at least one selected from the group consisting of sorbitan sesquioleate.

The auxiliary emulsifier may be included in 0.1 to 1% by weight based on the total weight of the composition.

In the present invention, the skin active ingredient is madecassoside (madecassoside), allantoin (allantoin), panthenol, betaine (betaine), retinol, retinyl palmitate (retinyl palmitate), retinyl acetate ( retinyl acetate, Coenzyme Q-10, elastin, collagen, hyaluronic acid, ascorbic acid, ascorbyl glucoside, alpha bisabo Rolls (alpha-bisabolol), tocopherol, tocopherol acetate, tocopherol acetate, albutin, niacinamide, tranexamic acid, adenosine, retinol acetate At least one selected from the group consisting of amino acids, mineral water, sodium hyaluronate, and plant extracts is preferred.

The skin active ingredient may be included in an amount of 0.01 to 10% by weight based on the total weight of the composition. When used in less than 0.01% by weight of the skin beauty effect is insignificant, when it exceeds 10% by weight may cause skin irritation and side effects depending on the ingredients.

Furthermore, the intercellular lipid mimetic composition of the present invention may be added with other additives such as preservatives, flavors, surfactants, etc., if necessary, the other additives are not particularly limited.

The composition containing the intercellular lipid mimetics according to the present invention can be prepared according to the following process.

First, an aqueous phase component comprising water (purified water), a polyhydric alcohol, and a water-soluble polymer is mixed and heated to about 75 to 80 ° C. to dissolve the component. At this time, when the temperature is less than 75 ° C, the components added to the water are not completely dissolved, and when it is above 80 ° C, the stability of some additives or natural components may be lowered.

In addition, apart from the aqueous phase component, an oil phase component including oil, wax and higher alcohol, an emulsifier and an auxiliary emulsifier are mixed and then heated to about 75 to 80 ° C. to dissolve the component.

While maintaining the temperature of about 75 to 80 ℃, the dissolved aqueous component and the oil phase component is mixed and stirred to emulsify.

Thereafter, the gelled polymer may be dispersed in a polyhydric alcohol separately, and then added to the emulsified mixture and sufficiently stirred while maintaining at about 70 to 85 ° C to obtain an intercellular lipid mimetic composition.

In addition, in a preferred embodiment of the present invention, after adding the gelling polymer, the mixture is maintained at about 70 to 85 ° C., and the skin efficacy component is added and stirred for an additional 3 to 5 minutes, thereby adding the skin efficacy component. Intercellular lipid mimetic compositions can be prepared. At this time, it is confirmed that the gelling polymer is sufficiently mixed.

The intercellular lipid mimetic composition prepared by such a process is in the range of pH 4-8, and has a viscosity of 500-5,000 cps. Within this range, the intercellular lipid mimetic composition may be stably contained in the hydrogel mask pack.

The present invention also provides a hydrogel mask pack containing the prepared intercellular lipid mimetic composition.

The mask pack containing the intercellular lipid capillary composition may be prepared according to the following process.

First, the intercellular lipid mimetic composition is coated on the support while maintaining at about 70 to 85 ° C. In this case, if the temperature is less than 70 ° C may not be sufficient gelation, the prepared intercellular lipid mimetic composition may be entangled, if the temperature is above 85 ° C some cosmetic components may be volatilized or less stable.

Thereafter, the intercellular lipid mimetic composition coated on the support may be cooled to room temperature and molded into a desired shape to obtain a final mask pack.

On the other hand, in the step of coating the intercellular lipid mimetic composition, the coating method is not particularly limited, it may be carried out by general application, dip coating, roll coating and the like.

At this time, the mask pack is preferably a thickness of 0.01 to 50mm. If the thickness is less than 0.01mm, the thickness may be excessively thin, which may cause the hydrogel to be torn when attached to the skin. have. If it exceeds 50mm, there is a problem that the skin adhesion is inferior because it is excessively thick, it is difficult to apply uniformly.

The support may be made of a nonwoven or fabric made of synthetic or natural fibers. Synthetic fibers may be made of a polymer resin including polypropylene (PP), polyethylene (PE), polyethylene terephthalate (PET), or may include nylon and rayon fibers. Natural fibers include cotton, hemp, wool, and paper. , Pulp, and the like, but is not limited thereto.

The support is preferably 0.1 to 5mm thick, if less than 0.1mm, the support may be easily damaged during storage, transportation and use, and if it exceeds 5mm, the hydrogel mask pack is too thick, making it difficult to attach to the face. There is.

The mask pack may be molded into a desired shape suitable for various body parts such as face, eyes, cheeks, chin, neck, mouth, etc. to obtain a final mask pack, and further, at least one release on one or both sides of the mask pack support. A film layer may be further included to protect the mask pack including the intercellular lipid mimetic composition.

Further, in some embodiments of the present invention, the intercellular lipid mimetic composition for mask packs may be poured into a mold molded into a desired shape to prepare a mask pack without a support.

Hereinafter, the present invention will be described in more detail with reference to specific examples. The following examples are merely examples to help understanding of the present invention, but the scope of the present invention is not limited thereto.

Preparation Example 1 Preparation of Intercellular Lipid Mimicking Composition

The intercellular lipid mimetic composition was prepared using the components described in Tables 1 and 2 below.

The water phase component was mixed in the main mixer tank and heated to 78 ° C. to dissolve the component. In addition, the oil phase component containing an emulsifier was heated in a separate oil phase tank and heated to 78 ° C. to dissolve the component. The dissolved oil phase component was added to the main mixer tank and stirred for 10 minutes using a homo mixer. Separately, the gelled polymer dispersed in the polyhydric alcohol was added to the emulsified mixture and further stirred for 5 minutes. In addition, the agonist ingredient was added to the mixture, followed by further stirring for 5 minutes to prepare an intercellular lipid mimetic composition.

division Raw material name Example 1 Comparative Example 1 Comparative Example 2 Comparative Example 3 Comparative Example 4 Awards
ingredient Purified water TO 100 TO 100 TO 100 TO 100 TO 100 IDT 0.02 0.02 0.02 0.02 0.02 glycerin 27 27 27 27 27 Butylene Glycol 2 2 2 2 2 Hydroxyethyl acrylate / sodium acryloyldimethyl taurate copolymer 0.2 0.2 0.2 0.2 0.2 Paid
ingredient Caprylic / Capric Triglyceride One One One One One Cetylethylhexanoate 0.5 0.5 0.5 0.5 0.5 Cetearyl Alcohol 0.1 0.1 0.1 0.1 0.1 Liquid crystal emulsifier Sucrose distearate 0.90 0.24 3.60 - - Hydrogenated Lecithin 0.45 0.12 1.80 - - Ceramide NP 0.15 0.04 0.60 - - Cetearyl Alcohol - - - 1.20 - Cetearylglucoside - - - 0.30 - C14-22 alcohol - - - - 1.20 C12-20 alkylglucoside - - - - 0.30 assistant
Emulsifier Polyglyceryl-3methylglucose distearate 0.1 0.1 0.1 0.1 0.1 skin
Efficacy Ingredient Adenosine 0.04 0.04 0.04 0.04 0.04 Niacinamide 2 2 2 2 2 Tocopheryl Acetate 2 2 2 2 2 Gelation
Polymer Irish Moss Powder 0.8 0.8 0.8 0.8 0.8 Carob Gum 2 2 2 2 2

division Raw material name Comparative Example 5 Comparative Example 6 Comparative Example 7 Awards
ingredient Purified water TO 100 TO 100 TO 100 IDT 0.02 0.02 0.02 glycerin 27 27 27 Butylene Glycol 2 2 2 Hydroxyethyl acrylate / sodium acryloyldimethyl taurate copolymer - 0.2 0.2 Paid
ingredient Caprylic / Capric Triglyceride 10 One One Cetylethylhexanoate 10 0.5 0.5 Cetearyl Alcohol 5 0.1 0.1 LCD
Emulsifier Sucrose distearate 0.90 - 0.90 Hydrogenated Lecithin 0.45 - 0.45 Ceramide NP 0.15 - 0.15 assistant
Emulsifier Polyglyceryl-3methylglucose distearate 0.1 0.1 0.1 skin
efficacy
ingredient Adenosine 0.04 0.04 - Niacinamide 2 2 - Tocopheryl Acetate 2 2 2 Gelation
Polymer Irish Moss Powder 0.8 0.8 0.8 Carob Gum 2 2 2

Preparation Example 2 Preparation of Mask Pack Containing Intercellular Lipid Mimicking Composition

The intercellular lipid mimetic compositions prepared in Preparation Example 1 were roll-coated on the nylon support to which the OPP film release paper was attached while maintaining at 80 ° C.

After the intercellular lipid mimetic composition coated on the support was cooled to room temperature, a final mask pack was prepared by molding using a face-shaped die. The appearance of the prepared hydrogel mask pack is shown in FIG.

Experimental Example 1: Identification of Liquid Crystal Particles According to Emulsifier Content

In order to analyze the liquid crystal particles of the intercellular lipid mimetic composition according to the content of the emulsifier, the composition liquid crystal particle states of Example 1 and Comparative Examples 1 and 2 were observed with a 400x polarization microscope and are shown in FIG. 2.

The results of polarizing microscope observation were evaluated by dividing the particles into clarity and uniformity, and are shown in Table 3 below on a five-point scale.

The clarity of the particles was determined to clearly show the scattering of light in the polarization microscope, and it means that the liquid crystal formation was visually confirmed with the 5th point.

(5: very good, 4: good, 3: normal, 2: not good, 1: very bad)

Example 1 Comparative Example 1 Comparative Example 2 Particle sharpness 5 2 One Particle Uniformity 5 One One

2 and Table 3, in the case of the intercellular lipid mimetic composition of Example 1 containing 1.5% by weight of an emulsifier, it can be seen that the liquid crystal particles were formed clearly and uniformly. On the other hand, in the case of the liquid crystal particles of Comparative Example 1 containing a small amount of the emulsifier 0.5% and the liquid crystal particles of Comparative Example 2 containing an excessive amount of the emulsifier 6.0% by weight it can be confirmed that the particles are not clear and uniformly formed.

Experimental Example 2: Check the physical properties and stability according to the type of liquid crystal emulsifier

The physical properties and stability of the composition to which the liquid crystal emulsifier of the present invention is applied and a typical representative liquid crystal emulsifier were analyzed.

As representative liquid crystal emulsifiers of the prior art, Comparative Example 3 using cetearyl alcohol and cetearyl glucoside and Comparative Example 4 containing C14-22 alcohol and C12-20 alkylglucoside were compared with Example 1, respectively. Total liquid crystal emulsifiers of Comparative Examples 3 and 4 were added in the same manner as in Example 1.

In the case of Comparative Example 3 to which the same amount of liquid crystal emulsifier as in Example 1 was added, a very high high viscosity was obtained as the initial physical property was 5,500 cps, which turned out to be inadequate viscosity when preparing a hydrogel mask pack.

In the case of Example 1 and Comparative Example 4, the initial physical properties are 2,000 cps and 3,000 cps, respectively, which are numerical values suitable for physical property standards.

Furthermore, in order to test the long-term stability of the intercellular lipid mimetic composition, the test was carried out for 3 months under severe conditions of 5 ° C. and 50 ° C. with 25 ° C. as a standard for Example 1 and Comparative Example 4, which meet the physical property standards. The results of measuring pH and viscosity are shown in Table 4 below.

Early 3 months later, 5 ℃ 3 months later, 25 ℃ 3 months later, 50 ℃ Example 1 pH 6.30 6.26 6.30 6.25 Viscosity (cps) 2,000 2,100 2,000 2,000
Comparative Example 4 pH 6.30 6.35 6.30 6.35 Viscosity (cps) 3,000 2,800 2,500 2,000

As a result of the experiment, the composition of Example 1 can be confirmed that the pH and viscosity were maintained at the initial value even in harsh conditions. However, the composition of Comparative Example 4 was confirmed that the long-term stability is not good because the viscosity is reduced compared to the initial value under severe conditions.

Accordingly, it was confirmed that the selection of an appropriate emulsifier affects the stability of the intercellular lipid mimetic composition.

Experimental Example 3: Checking the stability and feeling according to the content of the water-soluble polymer and the oil phase component

Stability and usability according to the content of the water-soluble polymer and the oil component in the components of the intercellular lipid mimetic composition of the present invention was analyzed.

The compositional stability of Comparative Example 5 was tested, including the same components as in Example 1, but containing an excess of the oil phase component in an amount of 25% by weight without using a water-soluble polymer in the aqueous phase component.

In order to test the stability of the compositions of Example 1 and Comparative Example 5, the particle state before and after three months of stability test was observed with a 400x polarization microscope and shown in FIG. The evaluation was carried out separately, and is shown in Table 5 below on a 5-point scale.

The clarity of the particles was determined to clearly show the scattering of light in the polarization microscope, and it means that the liquid crystal formation was visually confirmed with the 5th point.

(5: very good, 4: good, 3: medium, 2: bad, 1: very bad)

division Example 1 Comparative Example 5 Condition Initial 50 ° C 3 months later, 50 ℃ Initial 50 ° C 3 months later, 50 ℃ Particle sharpness 5 4 4 2 Particle Uniformity 5 5 4 2

As a result of the experiment, the composition of Example 1 was maintained even in the harsh conditions, the particle clarity and uniformity, the composition of Comparative Example 5 was confirmed that the stability of the particles are unstable, the sharpness and uniformity is lowered.

Accordingly, it was confirmed that the water-soluble polymer plays a secondary role in securing the emulsion stability of the liquid crystal structure in the long term.

In addition, using a hydrogel mask pack containing the composition of Example 1 and Comparative Example 5 to confirm the feeling, 10 people each of 20 men and women 20 minutes to attach to the face for a feeling questionnaire test 5 The scale is shown in Table 6 below.

(5: very good, 4: good, 3: normal, 2: not good, 1: very bad)

division Male (n = 10) Female (n = 10) Example 1 Comparative Example 5 Example 1 Comparative Example 5 Skin moisture 5 3 4 3 Skin stickiness 4 2 5 One Skin irritation 4 3 4 3 Overall satisfaction 4.5 3 5 2

As a result, Example 1 was found to have a higher overall satisfaction in terms of skin moisturizing power and stickiness compared to Comparative Example 5. Particularly, Comparative Example 5 contains an excessive amount of oily ingredients, so that the moisturizing power is moderate or sticky, and thus, it seems to have an adverse effect such as causing irritation to the skin.

Accordingly, the mask pack containing the interstitial lipid mimetics of Example 1 was found to be superior in terms of preference through excellent skin moisturizing power and overall skin improvement.

Experimental Example 4: Analysis of Percutaneous Absorption Rate of Active Skin Components with or Without Emulsifier

In order to evaluate the percutaneous absorption capability of the skin active ingredient and useful skin active ingredient for wrinkle improvement and whitening of the mask pack containing the intercellular lipid mimetic composition, a transdermal absorption device (Franz diffusion cell) was used.

The experiment was carried out on the composition of Example 1 and Comparative Example 6 containing no emulsifier.

0.15 g of the compositions of Example 1 and Comparative Example 6 were measured and applied to artificial skin, and the amounts of the skin active ingredients absorbed 30 minutes and 3 hours after attachment were analyzed by liquid chromatography, and are shown in Table 7 below. .

Active ingredient name Example 1 Comparative Example 6 Percutaneous absorption (ppm) Absorption rate (%) Percutaneous absorption (ppm) Absorption rate (%) 30 minutes after attachment Adenosine 0.2683 0.0671 0.1337 0.0001 Niacinamide 6.6991 0.0335 0.7347 0.0037 Tocopheryl Acetate 1.2369 0.0062 0.0232 N.D 3 hours after attachment Adenosine 0.2958 0.0739 0.1564 0.0390 Niacinamide 25.8346 0.1292 0.8852 0.0044 Tocopheryl Acetate 3.5104 0.0176 0.1395 0.0007

As a result, in Example 1, it was confirmed that the transdermal absorption ability of the water-soluble skin active ingredients adenosine and niacinamide and the oil-soluble skin active ingredient tocopheryl acetate was much better than the comparative example 6.

Accordingly, it can be expected that the intercellular lipid mimetic composition of Example 1 stably supports various skin active ingredients, and is efficiently delivered into the skin to improve skin such as whitening and wrinkle improvement.

Experimental Example 5: Skin Moisture Improvement Test

In order to confirm the skin moisture improvement effect of the mask pack containing the intercellular lipid mimetic composition, a test was conducted using a corneometer CM82 device.

Ten hydrogel mask packs containing the compositions of Example 1 and Comparative Example 6 were uniformly attached to the lower part of the eye for 1 hour to 10 adults aged 25 to 45 years.

In order to confirm the effect of improving moisture content, the skin moisture content was measured before use, 1 hour after use, and 6 hours after use, and the measured values are shown in Table 8 below.

division Example 1 Comparative Example 6 Moisture content measurement Rate of change Moisture content measurement Rate of change Before use 68.297 ± 4.277 - 71.927 ± 4.726 - 1 hour after use 79.812 ± 1.608 + 16.86% 75.992 ± 1.730 + 5.65% 6 hours after use 85.555 ± 4.472 + 25.27% 83.467 ± 3.088 + 16.04%

*% Change = (after-before) / before * 100

As a result of the experiment, compared to Comparative Example 6, the skin moisture content was clearly increased after 1 hour of use and after 6 hours of use.

Accordingly, it was confirmed that the mask pack containing the intercellular lipid mimetic composition of Example 1 has an effect of improving skin moisture content.

Experimental Example 6: Skin whitening improvement human application test

In order to confirm the whitening effect of the mask pack containing the intercellular lipid mimetic composition, a human application test was conducted using Spectrophotometer CM-700d and Mexameter MX18.

Hydrogel mask pack containing the interstitial lipid mimetic compositions prepared in Examples 1 and 7 once a day for a total of 8 weeks for 24 adult women with hyperpigmentation aged 30-60 years They were evenly attached to the face left and right, respectively.

The whitening effect was evaluated by measuring the skin brightness (L *) and melanin (M.I.) before, after 4 weeks, and after 8 weeks of use of the same hyperpigmentation site, and the measured values are shown in Tables 9 and 10 below.

division Example 1 Comparative Example 7 Skin Brightness Value (L *) Rate of change Skin Brightness Value (L *) Rate of change Before use 62.607 ± 3.329 - 62.844 ± 3.079 - 4 weeks after use 62.991 ± 3.603 + 0.604% 63.093 ± 3.550 + 0.377% 8 weeks after use 63.363 ± 3.224 + 1.225% 62.236 ± 2.995 -0.956%

division Example 1 Comparative Example 7 Melanin measurements (M.I.) Rate of change Melanin measurements (M.I.) Rate of change Before use 157.139 ± 25.658 - 158.583 ± 21.020 - 4 weeks after use 155.056 ± 25.763 -1.339% 157.569 ± 22.036 -0.714% 8 weeks after use 153.750 ± 25.649 -2.190% 158.611 ± 22.037 -0.058%

As a result, Example 1 significantly increased skin brightness and melanin significantly decreased after 8 weeks of use compared to Comparative Example 7.

Accordingly, it was confirmed that the mask pack containing the intercellular lipid mimetic composition of Example 1 has an effect of improving skin whitening.

Experimental Example 7: Skin wrinkle improvement human application test

Human application test was conducted to confirm the wrinkle improvement effect of the mask pack containing the intercellular lipid mimetic composition.

Each hydrogel mask pack containing the intercellular lipid mimetic compositions prepared in Examples 1 and 7 was once a day for a total of 8 weeks for 24 adult women with wrinkles around 30 to 60 years old. The face was evenly divided into left and right sides.

Wrinkle improvement effect was evaluated by measuring the depth of the wrinkles around the eyes before, after 4 weeks of use, 8 weeks after use of the same eye area wrinkles, the measurement values are shown in Table 11 below.

division Example 1 Comparative Example 7 Eye wrinkle value (Ra) Rate of change Eye wrinkle value (Ra) Rate of change Before use 23.590 ± 6.478 - 22.417 ± 6.258 - 4 weeks after use 22.770 ± 6.183 -3.378% 22.671 ± 6.323 + 1.140% 8 weeks after use 22.089 ± 5.899 -6.125% 22.293 ± 6.141 -0.510%

As a result, Example 1 significantly decreased the fold depth of the eye area after 8 weeks of use compared to Comparative Example 7. Accordingly, it was confirmed that the mask pack containing the intercellular lipid mimetic composition of Example 1 has an effect of improving skin wrinkles.

As described above in detail the specific parts of the contents of the present invention, for those skilled in the art, such specific description is only preferred embodiments, which are not intended to limit the scope of the present invention Will be obvious. Thus, the substantial scope of the present invention will be defined by the appended claims and their equivalents.

Claims (22)

Emulsifiers including sucrose compounds, lecithin compounds and ceramide compounds; Water phase component; Oil phase components; And a gelatinizing polymer composition for a mask pack, comprising a gelling polymer,
The emulsifier comprises 50 to 70% by weight of sucrose-based compound, 20 to 40% by weight of lecithin-based compound and 5 to 15% by weight of ceramide-based compound based on the total weight of the emulsifier, interstitial lipid irradiation for mask pack Sieve composition. The method of claim 1,
The sucrose-based compound is sucrose distearate, sucrose dilaurate, sucrose stearate, sucrose myristate, sucrose An intercellular lipid lipid mimetic composition for a mask pack, characterized in that at least one selected from the group consisting of sucrose laurate and sucrose palmitate. The method of claim 1,
The lecithin-based compound is at least one of lecithin (lecithin) and hydrogenated lecithin, characterized in that the intercellular lipid lipid mimetic composition for the mask pack. The method of claim 1,
The ceramide-based compound is at least one selected from the group consisting of Ceramide EOP, Ceramide NS, Ceramide NP, Ceramide AS and Ceramide AP. Characterized in the intercellular lipid lipid mimetic composition for the mask pack. delete The method of claim 1,
The emulsifier is 0.5 to 5% by weight based on the total weight of the total composition, characterized in that the intercellular lipid lipid mimetic composition for the mask pack. The method of claim 1,
Glyceryl stearate, polyglyceryl-3methylglucose distearate, polysorbate 60, cetearyl glucoside, cetearyl olivate ), Sorbitan olivate, PIG-100 stearate, PIG-60 hydrogenated castor oil, and sorbitan sesquioleate sesquioleate), further comprising one or more auxiliary emulsifiers selected from the group consisting of, interstitial lipid mimetic composition for the mask pack. The method of claim 1,
Madecassoside, allantoin, panthenol, betaine, retinol, retinyl palmitate, retinyl acetate, coenzyme Qten -10), elastin, collagen, hyaluronic acid, ascorbic acid, ascorbyl glucoside, alpha-bisabolol, tocopherol ( tocopherol, tocopherol acetate, albutin, niacinamide, tranexamic acid, adenosine, retinol acetate, amino acids, minerals An intercellular lipid mimetic composition for a mask pack further comprising at least one skin-efficacy component selected from the group consisting of water, sodium hyaluronate, and plant extracts. The method of claim 1,
The interphase lipid mimetic composition for a mask pack, characterized in that the water phase component comprises water, a polyhydric alcohol, and a water-soluble polymer. The method of claim 9,
The polyhydric alcohol is glycerin (glycerin), 1,3-butylene glycol (1,3-butylene glycol), dipropylene glycol (dipropylene glycol), 1,2-hexanediol (1,2-hexanediol) , Propanediol (propanediol), methyl propanediol (methyl propanediol), diglycerin (diclycerin) and ethylene glycol (ethylene glycol), characterized in that at least one selected from the group consisting of intercellular lipid lipid for mask pack. Carcass composition. The method of claim 9,
The water-soluble polymer is xanthan gum, carboxymethyl cellulose, carboxyethyl cellulose, polyacrylate, sodium polyacrylate, carboxyvinyl polymer ), Polyvinyl alcohol, polyacrylamide, polyethyleneoxide, polyethyleneimine, polyvinyl pyrrolidone, hydroxyethyl acrylate / sodium acryloyl Dimethylethyl acrylate / sodium acryloyldimethyltaurate copolymer, acrylate / C10-30 alkylacrylate crosspolymer, and ammonium acryloyldimethyl taurate / behenes-25 meta Ammoniumacryloyl dimethyltaurate / beheneth-25 methacrylate crosspoly mer) one or more selected from the group consisting of, interstitial lipid mimetic composition for a mask pack. The method of claim 1,
The oil phase component, characterized in that it contains an oil, wax and higher alcohol, intercellular lipid lipid mimetic composition for the mask pack. The method of claim 12,
The oil is ethylhexyl palmitate, isopropyl myristate, ethyl laurate, ethyl myristate, isopropyl palmitate, cyclopentane ), Cyclooctane, caprylic / capric triglyceride, butyleneglycol dicaprylate / dicaprate, triethylhexanoin , Pentaerythrityl tetrathylhexanoate, cetylethylhexanoate, isopropyl myristate, octyldodecanol, mineral oil, mineral oil, vaseline, hydrogenated polydecene, squalene, squalane, jojoba oil il), avocado oil, macadamia nut oil, palm oil, coconut oil, olive oil, argan oil, hawthorn oil, argan tree kernel oil, argania spinosa kernel oil, 1 selected from the group consisting of lavender oil, meadow foam seed oil, cyclomethicone, phenyltrimethicone, cyclopentasiloxane and dimethicone Intercellular lipid lipid mimetic composition for a mask pack, characterized in that the species or more. The method of claim 12,
The wax is at least one selected from the group consisting of carnauba wax, candelilla wax, bees wax, lanolin and microstalin wax. , Intercellular lipid lipid mimetic composition for mask pack. The method of claim 12,
The higher alcohol is selected from the group consisting of lauryl alcohol, lauryl alcohol, cetyl alcohol, stearyl alcohol, steteyl alcohol, cetearyl alcohol and behenyl alcohol. The intercellular lipid lipid mimetic composition for a mask pack, characterized in that above. The method of claim 1,
The gelling polymer is glucomannan, guamo gum, cyamopsis tetragonoloba (guar gum), carat gum (ceratonia siliqua (carob) gum), agar (agar), carrageenan, Irish moss powder (chondrus crispus powder), Xanthan gum, gellan gum, cellulose gum, konjac, chitosan, starch, pectin, pullulan, tamarind seed An intercellular lipid lipid mimetic composition for a mask pack, characterized in that at least one selected from the group consisting of a tamarindus indica seed gum and agar. The method of claim 1,
The pH of the intercellular lipid lipid mimetic composition for the mask pack is 4 to 8, characterized in that the viscosity of 500 to 5,000 cps, the intercellular lipid lipid mimetic composition for the mask pack. Method for preparing an intercellular lipid mimetic composition for a mask pack comprising the following steps:
(a) mixing the aqueous phase component and heating to 75-80 ° C. to dissolve it;
(b) mixing an oil phase component, an emulsifier and an auxiliary emulsifier, and then dissolving by heating at 75 to 80 ° C., wherein the emulsifier is 50 to 70 wt% of a sucrose-based compound and a lecithin-based compound 20 based on the total weight of the emulsifier. To 40% by weight and 5 to 15% by weight of the ceramide compound;
(c) adding a lysate of the oil phase component, emulsifier and auxiliary emulsifier to the aqueous phase component and then stirring to form a mixture; And
(d) dispersing the gelling polymer in a polyhydric alcohol and then adding to the mixture and stirring while maintaining at 70 to 85 ℃. The method of claim 18,
After step (d),
(e) adding the active ingredient of the skin while maintaining the mixture at 70 to 85 ℃, method for producing an intercellular lipid lipid mimetic composition for a mask pack. A hydrogel mask pack comprising the intercellular lipid lipid mimetic composition for a mask pack according to any one of claims 1 to 4 and 6 to 17. Coating an intercellular lipid mimetic composition for a mask pack according to any one of claims 1 to 4 and 6 to 17 at 70 to 85 ° C .; And
Method for producing a hydrogel mask pack comprising the step of forming a composition coated with a support after cooling to room temperature. 18. A method for manufacturing an intercellular lipid mimetic composition for a mask pack according to any one of claims 1 to 4 and 6 to 17; And
A method for producing a hydrogel mask pack comprising cooling to room temperature and separating the solidified mask pack from a mold.

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