KR102046830B1 - 허혈성 뇌 손상에 대한 효과적인 신경보호제이며 통증의 치료를 위한 ｐｓｄ-95의 고-친화성, 이량체 저해제 - Google Patents
허혈성 뇌 손상에 대한 효과적인 신경보호제이며 통증의 치료를 위한 ｐｓｄ-95의 고-친화성, 이량체 저해제 Download PDFInfo
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Images
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
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- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
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- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
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- General Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
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- Immunology (AREA)
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- Neurosurgery (AREA)
- Urology & Nephrology (AREA)
- Pain & Pain Management (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
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| US201161485898P | 2011-05-13 | 2011-05-13 | |
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| US61/485,898 | 2011-05-13 | ||
| EP11165994.2 | 2011-05-13 | ||
| PCT/EP2012/058762 WO2012156308A1 (en) | 2011-05-13 | 2012-05-11 | High-affinity, dimeric inhibitors of psd-95 as efficient neuroprotectants against ischemic brain damage and for treatment of pain |
Publications (2)
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| KR20140038435A KR20140038435A (ko) | 2014-03-28 |
| KR102046830B1 true KR102046830B1 (ko) | 2019-11-20 |
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| KR (1) | KR102046830B1 (enExample) |
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| BR (1) | BR112013029206B1 (enExample) |
| CA (1) | CA2833515C (enExample) |
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| ES (1) | ES2544573T3 (enExample) |
| IL (1) | IL228893B (enExample) |
| PL (1) | PL2707014T3 (enExample) |
| SG (1) | SG194717A1 (enExample) |
| WO (1) | WO2012156308A1 (enExample) |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| EP3074032B1 (en) | 2013-12-01 | 2018-12-26 | University of Copenhagen | Fatty acid derivatives of dimeric inhibitors of psd-95 |
| CN103804500B (zh) * | 2014-01-22 | 2015-12-30 | 广州军区广州总医院 | 用于治疗慢性疼痛的多肽 |
| EP3757134B1 (en) * | 2014-05-28 | 2024-03-06 | NoNO Inc. | Chloride salt of tat-nr2b9c |
| EP3650460A4 (en) * | 2017-07-05 | 2021-03-17 | Biocells (Beijing) Biotech Co., Ltd. | PHARMACEUTICAL SALT OF A POLYPEPTID AND ITS USES |
| EA202090802A1 (ru) | 2017-09-30 | 2020-08-05 | Биоселз (Бейдзин) Биотек Ко., Лтд. | Пептидная композиция для лечения повреждений, связанных с возбуждающей нейротоксичностью |
| US12077495B2 (en) | 2018-02-02 | 2024-09-03 | Københavns Universitet | Compounds for the treatment of acute brain injury |
| CN110627877A (zh) * | 2019-09-25 | 2019-12-31 | 成都奥达生物科技有限公司 | 一种psd-95抑制剂 |
| CN110787284A (zh) * | 2019-11-23 | 2020-02-14 | 胡书群 | 一种治疗缺血性脑损伤的混合小肽tat-shc及其应用 |
| KR20220117914A (ko) * | 2019-12-20 | 2022-08-24 | 피와이씨 테라퓨틱스 리미티드 | 신규 세포 전달 방법 |
| CN111285923B (zh) * | 2020-03-05 | 2023-02-03 | 成都奥达生物科技有限公司 | 一种psd-95抑制剂 |
| US20240301003A1 (en) * | 2021-01-08 | 2024-09-12 | Nono Inc. | Plasmin-resistant peptides for improved therapeutic index |
| TW202306965A (zh) | 2021-05-12 | 2023-02-16 | 哥本哈根大學 | Ｐｓｄ－９５抑制劑及其用途 |
| CN114533874B (zh) * | 2022-01-27 | 2023-12-29 | 北京和舆医药科技有限公司 | Psd-95 gk结构域作为神经保护靶点的用途 |
| CN121079099A (zh) * | 2023-04-26 | 2025-12-05 | 深圳信立泰药业股份有限公司 | 一种psd-95结构域抑制剂、其制备方法及其用途 |
| WO2025051130A1 (zh) * | 2023-09-07 | 2025-03-13 | 湖南中晟全肽生物科技股份有限公司 | 作为神经保护剂的药用化合物及其应用 |
| CN117164725B (zh) * | 2023-09-07 | 2024-05-10 | 湖南中晟全肽生物科技股份有限公司 | 一种突触后密度蛋白-95抑制剂多肽 |
| CN117903259B (zh) * | 2023-09-07 | 2024-09-20 | 湖南中晟全肽生物科技股份有限公司 | 一种psd-95抑制剂及其用途 |
| WO2025215348A1 (en) * | 2024-04-08 | 2025-10-16 | The Boots Company Plc | Skin wound treatment |
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| WO2010004003A2 (en) * | 2008-07-09 | 2010-01-14 | University Of Copenhagen | Modified peptides as potent inhibitors of the psd-95/nmda receptor interaction |
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| US7510824B2 (en) * | 1999-06-02 | 2009-03-31 | Nono Inc. | Method of screening peptides useful in treating traumatic injury to the brain or spinal cord |
| US20090285780A1 (en) | 2006-05-24 | 2009-11-19 | Chyi Lee | Peg linker compounds and biologically active conjugates thereof |
| WO2008008348A2 (en) * | 2006-07-11 | 2008-01-17 | Arbor Vita Corporation | Method and compositions for treating stroke with fever |
| US8080518B2 (en) * | 2007-12-05 | 2011-12-20 | Arbor Vita Corporation | Co-administration of an agent linked to an internalization peptide with an anti-inflammatory |
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Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| WO2010004003A2 (en) * | 2008-07-09 | 2010-01-14 | University Of Copenhagen | Modified peptides as potent inhibitors of the psd-95/nmda receptor interaction |
Also Published As
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|---|---|
| BR112013029206B1 (pt) | 2021-05-04 |
| CN103533949A (zh) | 2014-01-22 |
| CA2833515A1 (en) | 2012-11-22 |
| JP2014514365A (ja) | 2014-06-19 |
| CN103533949B (zh) | 2015-11-25 |
| ES2544573T3 (es) | 2015-09-01 |
| KR20140038435A (ko) | 2014-03-28 |
| EP2707014B1 (en) | 2015-06-17 |
| CA2833515C (en) | 2017-11-28 |
| BR112013029206A2 (pt) | 2017-02-14 |
| SG194717A1 (en) | 2013-12-30 |
| EP2707014A1 (en) | 2014-03-19 |
| IL228893B (en) | 2018-01-31 |
| IL228893A0 (en) | 2013-12-31 |
| JP6084207B2 (ja) | 2017-02-22 |
| AU2012257774A1 (en) | 2013-11-07 |
| AU2012257774B2 (en) | 2016-07-28 |
| DK2707014T3 (en) | 2015-09-14 |
| PL2707014T3 (pl) | 2015-12-31 |
| AU2012257774C1 (en) | 2016-11-03 |
| WO2012156308A1 (en) | 2012-11-22 |
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