CA2833515C - High-affinity, dimeric inhibitors of psd-95 as efficient neuroprotectants against ischemic brain damage and for treatment of pain - Google Patents
High-affinity, dimeric inhibitors of psd-95 as efficient neuroprotectants against ischemic brain damage and for treatment of pain Download PDFInfo
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- CA2833515C CA2833515C CA2833515A CA2833515A CA2833515C CA 2833515 C CA2833515 C CA 2833515C CA 2833515 A CA2833515 A CA 2833515A CA 2833515 A CA2833515 A CA 2833515A CA 2833515 C CA2833515 C CA 2833515C
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- 150000008163 sugars Chemical class 0.000 description 1
- 230000008093 supporting effect Effects 0.000 description 1
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- 239000012730 sustained-release form Substances 0.000 description 1
- 210000000225 synapse Anatomy 0.000 description 1
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- 239000006188 syrup Substances 0.000 description 1
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- 230000008685 targeting Effects 0.000 description 1
- 210000000966 temporal muscle Anatomy 0.000 description 1
- ACWLDITVZGWIKA-UHFFFAOYSA-N tert-butyl 3-(2-hydroxyethoxy)propanoate Chemical compound CC(C)(C)OC(=O)CCOCCO ACWLDITVZGWIKA-UHFFFAOYSA-N 0.000 description 1
- OKOWESVURLUVMD-UHFFFAOYSA-N tert-butyl 3-[2-(2-hydroxyethoxy)ethoxy]propanoate Chemical compound CC(C)(C)OC(=O)CCOCCOCCO OKOWESVURLUVMD-UHFFFAOYSA-N 0.000 description 1
- FJRDXEGYAVAMLB-UHFFFAOYSA-N tert-butyl 3-[2-[2-[2-(2-hydroxyethoxy)ethoxy]ethoxy]ethoxy]propanoate Chemical compound CC(C)(C)OC(=O)CCOCCOCCOCCOCCO FJRDXEGYAVAMLB-UHFFFAOYSA-N 0.000 description 1
- 125000005931 tert-butyloxycarbonyl group Chemical group [H]C([H])([H])C(OC(*)=O)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- 238000012956 testing procedure Methods 0.000 description 1
- YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 238000011285 therapeutic regimen Methods 0.000 description 1
- 150000003548 thiazolidines Chemical class 0.000 description 1
- 150000007970 thio esters Chemical class 0.000 description 1
- 150000003556 thioamides Chemical class 0.000 description 1
- 125000003396 thiol group Chemical group [H]S* 0.000 description 1
- 238000004448 titration Methods 0.000 description 1
- 229950003937 tolonium Drugs 0.000 description 1
- HNONEKILPDHFOL-UHFFFAOYSA-M tolonium chloride Chemical compound [Cl-].C1=C(C)C(N)=CC2=[S+]C3=CC(N(C)C)=CC=C3N=C21 HNONEKILPDHFOL-UHFFFAOYSA-M 0.000 description 1
- 238000012549 training Methods 0.000 description 1
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- 238000011269 treatment regimen Methods 0.000 description 1
- 150000003852 triazoles Chemical class 0.000 description 1
- PSVXZQVXSXSQRO-UHFFFAOYSA-N undecaethylene glycol Chemical compound OCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCO PSVXZQVXSXSQRO-UHFFFAOYSA-N 0.000 description 1
- 231100000691 up-and-down procedure Toxicity 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Immunology (AREA)
- Zoology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pain & Pain Management (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161485898P | 2011-05-13 | 2011-05-13 | |
| EP11165994 | 2011-05-13 | ||
| US61/485,898 | 2011-05-13 | ||
| EP11165994.2 | 2011-05-13 | ||
| PCT/EP2012/058762 WO2012156308A1 (en) | 2011-05-13 | 2012-05-11 | High-affinity, dimeric inhibitors of psd-95 as efficient neuroprotectants against ischemic brain damage and for treatment of pain |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2833515A1 CA2833515A1 (en) | 2012-11-22 |
| CA2833515C true CA2833515C (en) | 2017-11-28 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA2833515A Active CA2833515C (en) | 2011-05-13 | 2012-05-11 | High-affinity, dimeric inhibitors of psd-95 as efficient neuroprotectants against ischemic brain damage and for treatment of pain |
Country Status (13)
| Country | Link |
|---|---|
| EP (1) | EP2707014B1 (enExample) |
| JP (1) | JP6084207B2 (enExample) |
| KR (1) | KR102046830B1 (enExample) |
| CN (1) | CN103533949B (enExample) |
| AU (1) | AU2012257774C1 (enExample) |
| BR (1) | BR112013029206B1 (enExample) |
| CA (1) | CA2833515C (enExample) |
| DK (1) | DK2707014T3 (enExample) |
| ES (1) | ES2544573T3 (enExample) |
| IL (1) | IL228893B (enExample) |
| PL (1) | PL2707014T3 (enExample) |
| SG (1) | SG194717A1 (enExample) |
| WO (1) | WO2012156308A1 (enExample) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20160091980A (ko) | 2013-12-01 | 2016-08-03 | 유니버시티 오브 코펜하겐 | Psd-95의 이량체 억제제의 지방산 유도체 |
| CN103804500B (zh) * | 2014-01-22 | 2015-12-30 | 广州军区广州总医院 | 用于治疗慢性疼痛的多肽 |
| US10206973B2 (en) | 2014-05-28 | 2019-02-19 | Nono Inc. | Chloride salt of TAT-NR2B9c |
| AU2017422458B2 (en) | 2017-07-05 | 2021-07-15 | Biocells (Beijing) Biotech Co., Ltd. | Polypeptide pharmaceutically acceptable salt et use thereof |
| JP7073486B2 (ja) * | 2017-09-30 | 2022-05-23 | ▲拝▼西欧斯（北京）生物技▲術▼有限公司 | 興奮性神経毒性に関連した損傷の治療用ペプチド組成物 |
| CA3089161A1 (en) * | 2018-02-02 | 2019-08-08 | Kobenhavns Universitet | Compounds for the treatment of acute brain injury |
| CN110627877A (zh) * | 2019-09-25 | 2019-12-31 | 成都奥达生物科技有限公司 | 一种psd-95抑制剂 |
| CN110787284A (zh) * | 2019-11-23 | 2020-02-14 | 胡书群 | 一种治疗缺血性脑损伤的混合小肽tat-shc及其应用 |
| US20230048338A1 (en) * | 2019-12-20 | 2023-02-16 | PYC Therapeutics Limited | Novel cellular delivery methods |
| CN111285923B (zh) * | 2020-03-05 | 2023-02-03 | 成都奥达生物科技有限公司 | 一种psd-95抑制剂 |
| CA3203688A1 (en) * | 2021-01-08 | 2022-07-14 | Jonathan David Garman | Plasmin-resistant peptides for improved therapeutic index |
| TW202306965A (zh) | 2021-05-12 | 2023-02-16 | 哥本哈根大學 | Ｐｓｄ－９５抑制劑及其用途 |
| CN114533874B (zh) * | 2022-01-27 | 2023-12-29 | 北京和舆医药科技有限公司 | Psd-95 gk结构域作为神经保护靶点的用途 |
| WO2024222819A1 (zh) * | 2023-04-26 | 2024-10-31 | 深圳信立泰药业股份有限公司 | 一种psd-95结构域抑制剂、其制备方法及其用途 |
| CN119569824A (zh) * | 2023-09-07 | 2025-03-07 | 湖南中晟全肽生物科技股份有限公司 | 作为神经保护剂的药用化合物及其应用 |
| CN117164725B (zh) * | 2023-09-07 | 2024-05-10 | 湖南中晟全肽生物科技股份有限公司 | 一种突触后密度蛋白-95抑制剂多肽 |
| CN118027156B (zh) * | 2023-09-07 | 2024-11-05 | 湖南中晟全肽生物科技股份有限公司 | 一种psd-95抑制剂及其用途 |
| WO2025215348A1 (en) * | 2024-04-08 | 2025-10-16 | The Boots Company Plc | Skin wound treatment |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7510824B2 (en) * | 1999-06-02 | 2009-03-31 | Nono Inc. | Method of screening peptides useful in treating traumatic injury to the brain or spinal cord |
| WO2007140282A1 (en) | 2006-05-24 | 2007-12-06 | Peg Biosciences | Peg linker compounds and biologically active conjugates thereof |
| WO2008008348A2 (en) * | 2006-07-11 | 2008-01-17 | Arbor Vita Corporation | Method and compositions for treating stroke with fever |
| US8080518B2 (en) * | 2007-12-05 | 2011-12-20 | Arbor Vita Corporation | Co-administration of an agent linked to an internalization peptide with an anti-inflammatory |
| WO2010004003A2 (en) * | 2008-07-09 | 2010-01-14 | University Of Copenhagen | Modified peptides as potent inhibitors of the psd-95/nmda receptor interaction |
-
2012
- 2012-05-11 CN CN201280023754.8A patent/CN103533949B/zh active Active
- 2012-05-11 WO PCT/EP2012/058762 patent/WO2012156308A1/en not_active Ceased
- 2012-05-11 ES ES12720862.7T patent/ES2544573T3/es active Active
- 2012-05-11 BR BR112013029206-7A patent/BR112013029206B1/pt active IP Right Grant
- 2012-05-11 CA CA2833515A patent/CA2833515C/en active Active
- 2012-05-11 DK DK12720862.7T patent/DK2707014T3/en active
- 2012-05-11 EP EP12720862.7A patent/EP2707014B1/en active Active
- 2012-05-11 SG SG2013080718A patent/SG194717A1/en unknown
- 2012-05-11 AU AU2012257774A patent/AU2012257774C1/en active Active
- 2012-05-11 PL PL12720862T patent/PL2707014T3/pl unknown
- 2012-05-11 JP JP2014510747A patent/JP6084207B2/ja active Active
- 2012-05-11 KR KR1020137031532A patent/KR102046830B1/ko active Active
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2013
- 2013-10-15 IL IL228893A patent/IL228893B/en active IP Right Grant
Also Published As
| Publication number | Publication date |
|---|---|
| DK2707014T3 (en) | 2015-09-14 |
| BR112013029206A2 (pt) | 2017-02-14 |
| SG194717A1 (en) | 2013-12-30 |
| WO2012156308A1 (en) | 2012-11-22 |
| KR102046830B1 (ko) | 2019-11-20 |
| AU2012257774A1 (en) | 2013-11-07 |
| PL2707014T3 (pl) | 2015-12-31 |
| EP2707014A1 (en) | 2014-03-19 |
| CA2833515A1 (en) | 2012-11-22 |
| EP2707014B1 (en) | 2015-06-17 |
| IL228893B (en) | 2018-01-31 |
| BR112013029206B1 (pt) | 2021-05-04 |
| CN103533949A (zh) | 2014-01-22 |
| ES2544573T3 (es) | 2015-09-01 |
| AU2012257774B2 (en) | 2016-07-28 |
| CN103533949B (zh) | 2015-11-25 |
| IL228893A0 (en) | 2013-12-31 |
| AU2012257774C1 (en) | 2016-11-03 |
| JP2014514365A (ja) | 2014-06-19 |
| JP6084207B2 (ja) | 2017-02-22 |
| KR20140038435A (ko) | 2014-03-28 |
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| EEER | Examination request |
Effective date: 20170317 |