KR102018240B1 - (r)-레티큘린 및 그 전구체를 제조하기 위한 조성물 및 방법 - Google Patents

(r)-레티큘린 및 그 전구체를 제조하기 위한 조성물 및 방법 Download PDF

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KR102018240B1
KR102018240B1 KR1020167017344A KR20167017344A KR102018240B1 KR 102018240 B1 KR102018240 B1 KR 102018240B1 KR 1020167017344 A KR1020167017344 A KR 1020167017344A KR 20167017344 A KR20167017344 A KR 20167017344A KR 102018240 B1 KR102018240 B1 KR 102018240B1
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KR20160093042A (ko
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피터 제임스 파치니
스콧 카메론 패로우
기욤 아서 웰치 보두앙
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에피메론 인코포레이티드
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KR1020167017344A 2013-12-04 2014-12-03 (r)-레티큘린 및 그 전구체를 제조하기 위한 조성물 및 방법 Active KR102018240B1 (ko)

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KR1020197025315A KR102491060B1 (ko) 2013-12-04 2014-12-03 (r)-레티큘린 및 그 전구체를 제조하기 위한 조성물 및 방법

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US201361911759P 2013-12-04 2013-12-04
US61/911,759 2013-12-04
US201462050399P 2014-09-15 2014-09-15
US62/050,399 2014-09-15
PCT/CA2014/051164 WO2015081437A1 (en) 2013-12-04 2014-12-03 Compositions and methods for making (r)-reticuline and precursors thereof

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US (3) US10190141B2 (https=)
EP (2) EP3077513B1 (https=)
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CN (3) CN115927139A (https=)
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Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK3553177T3 (da) 2013-03-15 2021-02-15 Univ Leland Stanford Junior Benzylisoquinolinalkaloider (bia) som producerer mikrober, og fremgangsmåder til fremstilling og anvendelse deraf
CN112410379B (zh) 2013-11-04 2024-12-31 小利兰·斯坦福大学托管委员会 产生苄基异喹啉生物碱(bia)前体的微生物以及制备和使用所述前体的方法
JP6783655B2 (ja) * 2013-12-04 2020-11-11 エピメロン インコーポレイテッドＥｐｉｍｅｒｏｎ Ｉｎｃ． （ｒ）−レチクリンおよびその前駆体を製造するための組成物および方法
WO2015173590A1 (en) * 2014-05-16 2015-11-19 The Unversity Of York Novel cytochrome p450 fusion protein
EP3292203A4 (en) 2015-05-04 2019-10-09 The Board of Trustees of the Leland Stanford Junior University BENZYL ISOCHINOLIN ALKALOID (BIA) Precursor Producing Microbicides and Method for the Preparation and Use Thereof
JP7266966B2 (ja) 2015-05-08 2023-05-01 ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー エピメラーゼ及びベンジルイソキノリンアルカロイドを産生する方法
GB201511156D0 (en) * 2015-06-24 2015-08-05 Glaxosmithkline Australia Pty Ltd And University Of York Production of alkaloids
EP3475426A4 (en) * 2016-06-27 2020-08-19 Serturner Corp. POLYNUCLEOTIDES AND POLYPEPTIDES USEFUL FOR THE MANUFACTURE OF ALKALOID COMPOUNDS
AU2017290594B2 (en) 2016-06-27 2022-02-17 Intrexon Corporation Compositions and methods for making benzylisoquinoline alkaloids, morphinan alkaloids, thebaine, and derivatives thereof
CN106119265B (zh) * 2016-06-30 2019-04-30 湖南美可达生物资源股份有限公司 博落回中参与血根碱与白屈菜红碱合成的细胞色素p450酶基因及其应用
WO2018075670A1 (en) 2016-10-18 2018-04-26 Antheia, Inc. Methods of producing nor-opioid and nal-opioid benzylisoquinoline alkaloids
WO2019028390A1 (en) 2017-08-03 2019-02-07 Antheia, Inc. ALKALOID BENZYLISOQUINOLEIN GENETICALLY MODIFIED EPIMERASES AND METHODS FOR PRODUCING BENZYLISOQUINOLINE ALKALOIDS
WO2019157383A2 (en) 2018-02-08 2019-08-15 Antheia, Inc. Methods of producing morphinan alkaloids and derivatives
CN120399912A (zh) 2019-03-08 2025-08-01 小利兰·斯坦福大学托管委员会 产生莨菪烷生物碱(ta)的非植物宿主细胞及其制备和使用方法
EP3988663A4 (en) 2019-06-24 2023-08-02 Ishikawa Prefectural Public University Corporation Production method of (r)-reticulin
AU2023376563A1 (en) 2022-11-08 2025-05-01 River Stone Biotech Aps Genetically modified benzylisoquinoline alkaloid-producing host cells with modified efflux transporter gene expression
CN119776567A (zh) * 2024-12-16 2025-04-08 广西壮族自治区农业科学院 鉴定番荔枝种质资源的分子标记引物试剂盒及应用

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000058333A1 (en) 1999-03-26 2000-10-05 Johnson & Johnson Research Pty. Limited Codeinone reductase from alkaloid poppy

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3785927A (en) 1973-02-12 1974-01-15 Merck & Co Inc Process for converting(-)reticuline to(+)salutaridine
GB1408729A (en) * 1973-08-13 1975-10-01 Lilly Co Eli Sulphilimine compounds
US5268463A (en) 1986-11-11 1993-12-07 Jefferson Richard A Plant promoter α-glucuronidase gene construct
JPWO2005033305A1 (ja) * 2003-09-17 2007-11-29 国立大学法人京都大学 ＲＮＡｉ法を用いた有用アルカロイド生合成中間体の生産法
EP1837396A1 (en) * 2006-03-23 2007-09-26 Institut für Pflanzenbiochemie-IPB Salutaridine reductase and morphine biosynthesis
WO2008067070A2 (en) * 2006-10-19 2008-06-05 California Institute Of Technology Compositions and methods for producing benzylisoquinolines alkaloids
WO2011058446A2 (en) 2009-11-12 2011-05-19 Uti Limited Partnership Thebaine 6-o-demethylase and codeine o-demethylase from papaver somniferum
JP6783655B2 (ja) * 2013-12-04 2020-11-11 エピメロン インコーポレイテッドＥｐｉｍｅｒｏｎ Ｉｎｃ． （ｒ）−レチクリンおよびその前駆体を製造するための組成物および方法
WO2015103711A1 (en) 2014-01-13 2015-07-16 Valorbec Société en Commandite Method of making a benzylisoquinoline alkaloid (bia) metabolite, enzymes therefore
WO2015173590A1 (en) 2014-05-16 2015-11-19 The Unversity Of York Novel cytochrome p450 fusion protein
JP7266966B2 (ja) 2015-05-08 2023-05-01 ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー エピメラーゼ及びベンジルイソキノリンアルカロイドを産生する方法

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000058333A1 (en) 1999-03-26 2000-10-05 Johnson & Johnson Research Pty. Limited Codeinone reductase from alkaloid poppy

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
BMC Plant Biology, Vol. 10, pp. 252 (1-17) (2010.11.18.)
Tetrahedron Letters, Vol. 31, pp. 4855-4858 (1990.)

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AU2020201743B2 (en) 2022-03-17
CA2932448C (en) 2021-08-31
BR112016012595B1 (pt) 2024-02-27
US20240002894A1 (en) 2024-01-04
CN105980563A (zh) 2016-09-28
IL271289A (en) 2020-01-30
AU2014360597A1 (en) 2016-06-09
DK3077513T3 (da) 2023-10-23
AU2020200131A1 (en) 2020-01-30
KR20160093042A (ko) 2016-08-05
MX2016007176A (es) 2016-12-08
RU2729065C2 (ru) 2020-08-04
WO2015081437A1 (en) 2015-06-11
CA2932448A1 (en) 2015-06-11
BR112016012595A2 (pt) 2017-09-26
US11613770B2 (en) 2023-03-28
KR102491060B1 (ko) 2023-01-20
IL271289B (en) 2022-04-01
MX364825B (es) 2019-05-08
CN115927139A (zh) 2023-04-07
US20190241919A1 (en) 2019-08-08
EP3077513A4 (en) 2017-06-21
US10190141B2 (en) 2019-01-29
KR20190108160A (ko) 2019-09-23
US20160312256A1 (en) 2016-10-27
EP4289959A1 (en) 2023-12-13
ES2961516T3 (es) 2024-03-12
EP3077513A1 (en) 2016-10-12
IL245970B (en) 2019-12-31
CN115927140A (zh) 2023-04-07
AU2022279419A1 (en) 2023-01-19
AU2020201743A1 (en) 2020-03-26
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JP6783655B2 (ja) 2020-11-11

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