CN115927139A - 用于制备(r)-网状番荔枝碱及其前体的组合物和方法 - Google Patents

用于制备(r)-网状番荔枝碱及其前体的组合物和方法 Download PDF

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CN115927139A
CN115927139A CN202210963296.1A CN202210963296A CN115927139A CN 115927139 A CN115927139 A CN 115927139A CN 202210963296 A CN202210963296 A CN 202210963296A CN 115927139 A CN115927139 A CN 115927139A
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reticuline
nucleic acid
acid sequence
akr
cyp450
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Chinese (zh)
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彼得·詹姆斯·法基尼
斯科特·卡梅伦·法罗
纪劳姆·亚瑟·韦尔奇·博杜安
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Antheia Inc
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Antheia Inc
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    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01H—NEW PLANTS OR NON-TRANSGENIC PROCESSES FOR OBTAINING THEM; PLANT REPRODUCTION BY TISSUE CULTURE TECHNIQUES
    • A01H1/00—Processes for modifying genotypes ; Plants characterised by associated natural traits
    • A01H1/04—Processes of selection involving genotypic or phenotypic markers; Methods of using phenotypic markers for selection
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
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    • A01H1/00—Processes for modifying genotypes ; Plants characterised by associated natural traits
    • A01H1/06—Processes for producing mutations, e.g. treatment with chemicals or with radiation
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01H—NEW PLANTS OR NON-TRANSGENIC PROCESSES FOR OBTAINING THEM; PLANT REPRODUCTION BY TISSUE CULTURE TECHNIQUES
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    • C07D217/22—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the nitrogen-containing ring
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    • C12N9/0071—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
    • C12N9/0077—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14) with a reduced iron-sulfur protein as one donor (1.14.15)
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  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Other In-Based Heterocyclic Compounds (AREA)
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CN202210963296.1A 2013-12-04 2014-12-03 用于制备(r)-网状番荔枝碱及其前体的组合物和方法 Pending CN115927139A (zh)

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US201361911759P 2013-12-04 2013-12-04
US61/911,759 2013-12-04
US201462050399P 2014-09-15 2014-09-15
US62/050,399 2014-09-15
PCT/CA2014/051164 WO2015081437A1 (en) 2013-12-04 2014-12-03 Compositions and methods for making (r)-reticuline and precursors thereof
CN201480071559.1A CN105980563B (zh) 2013-12-04 2014-12-03 用于制备(r)-网状番荔枝碱及其前体的组合物和方法

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CN202210963307.6A Pending CN115927140A (zh) 2013-12-04 2014-12-03 用于制备(r)-网状番荔枝碱及其前体的组合物和方法
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CN201480071559.1A Active CN105980563B (zh) 2013-12-04 2014-12-03 用于制备(r)-网状番荔枝碱及其前体的组合物和方法

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CN112410379B (zh) 2013-11-04 2024-12-31 小利兰·斯坦福大学托管委员会 产生苄基异喹啉生物碱(bia)前体的微生物以及制备和使用所述前体的方法
JP6783655B2 (ja) * 2013-12-04 2020-11-11 エピメロン インコーポレイテッドＥｐｉｍｅｒｏｎ Ｉｎｃ． （ｒ）−レチクリンおよびその前駆体を製造するための組成物および方法
WO2015173590A1 (en) * 2014-05-16 2015-11-19 The Unversity Of York Novel cytochrome p450 fusion protein
EP3292203A4 (en) 2015-05-04 2019-10-09 The Board of Trustees of the Leland Stanford Junior University BENZYL ISOCHINOLIN ALKALOID (BIA) Precursor Producing Microbicides and Method for the Preparation and Use Thereof
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GB201511156D0 (en) * 2015-06-24 2015-08-05 Glaxosmithkline Australia Pty Ltd And University Of York Production of alkaloids
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AU2017290594B2 (en) 2016-06-27 2022-02-17 Intrexon Corporation Compositions and methods for making benzylisoquinoline alkaloids, morphinan alkaloids, thebaine, and derivatives thereof
CN106119265B (zh) * 2016-06-30 2019-04-30 湖南美可达生物资源股份有限公司 博落回中参与血根碱与白屈菜红碱合成的细胞色素p450酶基因及其应用
WO2018075670A1 (en) 2016-10-18 2018-04-26 Antheia, Inc. Methods of producing nor-opioid and nal-opioid benzylisoquinoline alkaloids
WO2019028390A1 (en) 2017-08-03 2019-02-07 Antheia, Inc. ALKALOID BENZYLISOQUINOLEIN GENETICALLY MODIFIED EPIMERASES AND METHODS FOR PRODUCING BENZYLISOQUINOLINE ALKALOIDS
WO2019157383A2 (en) 2018-02-08 2019-08-15 Antheia, Inc. Methods of producing morphinan alkaloids and derivatives
CN120399912A (zh) 2019-03-08 2025-08-01 小利兰·斯坦福大学托管委员会 产生莨菪烷生物碱(ta)的非植物宿主细胞及其制备和使用方法
EP3988663A4 (en) 2019-06-24 2023-08-02 Ishikawa Prefectural Public University Corporation Production method of (r)-reticulin
AU2023376563A1 (en) 2022-11-08 2025-05-01 River Stone Biotech Aps Genetically modified benzylisoquinoline alkaloid-producing host cells with modified efflux transporter gene expression
CN119776567A (zh) * 2024-12-16 2025-04-08 广西壮族自治区农业科学院 鉴定番荔枝种质资源的分子标记引物试剂盒及应用

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JP7266966B2 (ja) 2015-05-08 2023-05-01 ザ ボード オブ トラスティーズ オブ ザ レランド スタンフォード ジュニア ユニバーシティー エピメラーゼ及びベンジルイソキノリンアルカロイドを産生する方法

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AU2022279419B2 (en) 2025-07-24
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CA2932448C (en) 2021-08-31
BR112016012595B1 (pt) 2024-02-27
US20240002894A1 (en) 2024-01-04
CN105980563A (zh) 2016-09-28
IL271289A (en) 2020-01-30
AU2014360597A1 (en) 2016-06-09
DK3077513T3 (da) 2023-10-23
AU2020200131A1 (en) 2020-01-30
KR20160093042A (ko) 2016-08-05
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RU2729065C2 (ru) 2020-08-04
WO2015081437A1 (en) 2015-06-11
CA2932448A1 (en) 2015-06-11
BR112016012595A2 (pt) 2017-09-26
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US20190241919A1 (en) 2019-08-08
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US10190141B2 (en) 2019-01-29
KR20190108160A (ko) 2019-09-23
US20160312256A1 (en) 2016-10-27
EP4289959A1 (en) 2023-12-13
ES2961516T3 (es) 2024-03-12
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EP3077513A1 (en) 2016-10-12
IL245970B (en) 2019-12-31
CN115927140A (zh) 2023-04-07
AU2022279419A1 (en) 2023-01-19
AU2020201743A1 (en) 2020-03-26
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JP6783655B2 (ja) 2020-11-11

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