KR102013871B1 - Composition for improving hair growth - Google Patents

Abstract

This embodiment is 10 to 25% by weight black sesame powder, 5 to 15% by weight kelp powder, 1 to 10% by weight seaweed powder, 1 to 10% by weight sewage powder, 1 to 5% by weight walnut powder, scalp penetrant: 5 ~ 20% by weight, Broccoli extract 0.1-3.0%, Krabi sprout extract 0.1-3.0%, alkylphenol ethoxylate 0.5-3%, N-methacryloxy-N-carboxymetalpiperidine 3-5% It relates to a composition for promoting hair growth comprising a% and a solvent: 10 to 50% by weight.

Description

Composition for promoting hair growth {Composition for improving hair growth}

This embodiment relates to a composition for promoting hair growth.

The contents described below provide background information on the present embodiment, but do not describe the prior art.

Hair is a protein filament that grows in the hair follicle of the skin dermis. Hair follicles are largely composed of dermal papilla, matrix surrounding dermal papilla, and root sheath. The dermal papilla is mainly composed of connective tissue and capillaries, and surrounds the hair root to supply nutrients and oxygen. The matrix is composed of epithelial cells and melanocytes, and cell division actively occurs. Here, the divided cells keratinize, creating hair and growing out of the skin. Root sheath is an inner root sheath and outer root sheath, which serves to protect the growing hair until it is fully aerated and reach the skin epidermis. The hair grows, falls out and regrows periodically through the growth, anagen, catagen, telogen, and hair loss phases. The hair grows in the hair follicles as the hair grows, and stem cells in the hair follicle bulge are activated to form new substrates during the initial growth phase, and the hair shaft and inner hair from relatively undifferentiated basal cells. Hairy roots are produced. The size and length of the hair stem are proportional to the size of the hair follicle and the duration of the hair growth phase, respectively.

Alopecia refers to abnormally low or missing hair density in areas where hair should normally be present, and is classified into scars and non scars. Scar alopecia is hair loss and recovery to fibrous tissue that leads to permanent hair loss. Scarring and infection from trauma, burns, tumors, and surgery are the main causes. Non-cancerous alopecia is a condition in which tissues are not fibrotic and hair follicles are preserved, such as alopecia areata, resting / growth alopecia, feminine alopecia, and hereditary androgen alopecia. The cause of hair loss is not clear, but environmental and genetic factors such as air pollution, dietary habits, stress, hormonal imbalance, autonomic nervous system and blood circulation disorders, excessive sebum production, malnutrition of hair roots, allergies, bacterial infections, It is estimated that physiological factors such as aging work in combination. Alopecia occurred only in the middle and middle age group in the past, but recently occurs frequently among young people in their 20s and 30s.

Therefore, cosmetics or pharmaceutical research and development has been actively conducted to improve the hair loss phenomenon and promote hair growth. Currently, the hair loss treatment agent approved by the US Food and Drug Administration (FDA) and the commercially available hair loss treatment agent are minoxidil and oral There is finasteride. Minoxidil induces hair growth by expanding blood vessels to increase blood flow and nourish hair roots, while finasteride is a specific inhibitor of type II 5-reductase that prevents testosterone from converting to dihydrotestosterone. It is known to suppress.

These hair regrowth treatments are effective in preventing hair loss because they are effective only in the area where the hair root is activated, but the growth effects of the hair in a long-term rest period are insignificant, or the effects last only during administration. In particular, drugs that regulate male hormones may cause side effects such as decreased libido and erectile dysfunction. Therefore, it is necessary to develop a safe and economical hair growth promoting technology that prevents hair loss and promotes hair growth, the effect can be maintained stably, and side effects are low.

In the present embodiment, while studying natural substances capable of promoting hair growth and inhibiting skin inflammation that can cause hair loss, a collagen sprout extract, broccoli sprout extract, seaweed kelp powder, and seaweed powder are synthesized. Penetrants use Triton-X or povidone to provide compositions having hair growth promoting and anti-inflammatory effects.

The hair growth promoting composition according to the present invention is black sesame powder 10 to 25% by weight, kelp powder 5 to 15% by weight, seaweed powder 1 to 10% by weight, sewage powder 1 to 10% by weight, walnut powder 1 to 5% by weight, Scalp Penetrant: 5-20 wt%, Broccoli Extract 0.1-3.0 wt%, Krabi Sprout Extract 0.1-3.0 wt%, Alkylphenolethoxylate 0.5-3 wt%, N-methacryloxy-N-carboxymetalpiperi 3 to 5 wt% of dean and 10 to 50 wt% of solvent.

The scalp penetration agent may use Triton-X or povidone, and the broccoli extract and the kohlrabi sprout extract are added in a weight ratio of 1: 0.5 to 1: 0.8, and more preferably, Broccoli extract and kohlrabi sprout extract may be added in a weight ratio of 1: 0.61.

Through this embodiment, using the Kohlrabi extract, broccoli extract, and provides a hair growth promoting and anti-inflammatory food composition and cosmetic composition comprising Triton-X (Priton-X) or povidone as a scalp penetration agent. The composition of the present invention has the effect of increasing the activity and / or expression of the factors that promote hair growth in the skin to create a skin environment to promote hair growth, and excellent effect of inhibiting skin inflammation that can cause hair loss and dandruff There is.

Hereinafter, some embodiments of the present invention will be described through exemplary drawings for the convenience of description. However, the technical idea of the present invention is not limited to some embodiments described.

In addition, in describing the components of the embodiments of the present disclosure, terms such as first, second, A, B, (a), and (b) may be used. These terms are only for distinguishing the components from other components, and the nature, order or order of the components are not limited by the terms.

When a component is described as being 'connected' or 'coupled' to another component, the component may be directly connected or coupled to the other component, but there is another component between the component and the other component. It is to be understood that the elements may be 'connected' or 'coupled'.

Hair growth promoting composition

Hair growth promoting composition according to an embodiment of the present invention is black sesame powder 10 to 25% by weight, kelp powder 5 to 15% by weight, seaweed powder 1 to 10% by weight, sewage powder 1 to 10% by weight, walnut powder 1 to 5 Weight%, Scalp Penetrating Agent: 5-20% by weight, Broccoli Extract 0.1-3.0% by weight, Krabi sprout extract 0.1-3.0% by weight, 0.5-3% by weight of alkylphenolethoxylate, N-methacryloxy-N-carboxy Metal piperidine 3 to 5% by weight and solvent: 10 to 50% by weight.

Black soybeans are similar in nutrient content compared to regular soybeans, but four times more anti-aging ingredients and effective in preventing adult diseases. In particular, cysteine (cysteine), which is essential for hair growth, is effective in preventing hair loss. These black beans can help your kidneys and bladder function when taken continuously. Black sesame lipids nourish blood vessels and scalp. In addition, black sesame seeds contain a mixture of unsaturated fatty acids such as linolenic acid and linoleic acid, as well as amino acids, vitamin E, calcium, iron, vitamins B1 and B2, to help with hair health. Therefore, black sesame powder is preferably added in an amount of 10 to 25% by weight of the total weight of the composition for promoting hair growth according to an embodiment of the present invention.

Kelp is a tonic that protects the kidneys, prevents hair loss, promotes hair growth, and has the highest iodine content among seaweeds, and has a high content of calcium (Ca) and phosphorus (P). In addition, kelp lowers blood cholesterol, helps intestinal activity, and accelerates bone growth. Therefore, the kelp powder is preferably added in a content ratio of 5 to 15% by weight of the total weight of the hair growth promoting composition according to an embodiment of the present invention.

Seaweed contains a large amount of minerals to regulate the flow of water in the body, ease dissolution, treat gynecological diseases, prevent hypertension and atherosclerosis obesity, and supply thyroid hormone thyroxine. Therefore, the seaweed powder is preferably added in an amount of 1 to 10% by weight of the total weight of the composition for promoting hair growth according to an embodiment of the present invention.

Sewage has excellent tonic effect, strengthening the function of liver and kidney, strengthening the musculature, preventing hair loss and treating. Therefore, sewage powder is preferably added in an amount of 1 to 10% by weight of the total weight of the composition for promoting hair growth according to an embodiment of the present invention.

Walnuts are rich in high quality proteins and unsaturated fatty acids, and are rich in vitamins and minerals to help prevent hair loss. Such walnut is preferably added in an amount of 1 to 5% by weight of the total weight of the composition for promoting hair growth according to an embodiment of the present invention.

Scalp penetrants use dimethyl sulfoxide (DMSO), Triton-X or povidone, and are used to enhance the penetration of pharmaceutical components into the dermal layer deep into the scalp. In particular, the addition of menthol, a skin stimulant, increases skin irritation, which further enhances the effect of the pharmaceutical ingredient on the dermal layer of the skin. At this time, the scalp penetrants such as dimethyl sulfoxide, Triton-X, povidone, etc. are each contained in an amount of 1 to 20% by weight based on the total weight of the final composition, and skin irritants such as menthol are included in 1 to 5% by weight of the total weight of the final composition. Preferred, especially when the scalp penetrants dimethyl sulfoxide, Triton-X and povidone are used separately, 1.0 to 20% by weight of dimethyl sulfoxide, 1.0 to 10.0% by weight of triton-X and povidone relative to the total weight of the final composition It is preferably included in 1.0 to 5.0% by weight. In particular, the old scalp layer, such as bald head is difficult to penetrate the usual active ingredients, many kinds of hair growth, hair growth agent is also a major cause that does not exhibit its efficacy. Among them, dimethyl sulfoxide (DMSO) is preferable as a scalp penetrant, and DMSO is a low molecular compound, which has a property of passing through a biological membrane well and increasing cell membrane permeability of other substances. DMSO also has an antioxidant action that removes hydroxy radicals (OH '). DMSO has the advantage of dissolving water, alcohol and almost all organic and biochemicals, and is widely used as a solvent for biopolymers in nuclear magnetic resonance analyzers. The mechanism by which DMSO helps infiltrate the scalp has not been elucidated, but it is believed to be due to the ability to instantly dissolve polymers such as proteins with excellent dissolving power.

The present invention is a collagen sprout extract hair gamma-glutamyl transpeptidase (γ-glutamyl transpeptidase), alkaline phosphatase (ALP), epidermal growth factor (EGF), vascular endothelial growth factor (VEGF) hair Increasing the amount of activity and / or expression of the factors that induce growth to create a skin environment that promotes hair growth, has been found to have an excellent effect in inhibiting skin inflammation that can cause hair loss and dandruff. In particular, the broccoli sprout extract, the kelp extract in addition to the composition was found to further increase the hair growth and anti-inflammatory effect, and also by using the effect of the mixed extract composition of plants and algae safe and effective hair growth It can be used to develop foods for promotion and anti-inflammatory.

In the present invention, 'kohlrabi' is a plant belonging to the group belonging to the group of Brassica oleracea spp Gongylodes of the genus Brassica oleracea, which is also called a German turnip or turnip cabbage. to be. Kohlabi leaves and light green or purple bulbs (tube stems) are used for food. The kohlrabi in the present invention may be kohlrabi or sprout of kohlrabi.

In the present invention, 'broccoli' is a plant belonging to Brassica oleracea, also called green cauliflower. One type of flowering cabbage began to be bred in Italy, where it was bred to suppress the development of the flower, giving it a present appearance with numerous florets from thick stalks. Both stem and flower eyes are eaten. Broccoli in the present invention may be broccoli or sprout of broccoli.

The cosmetic composition according to the present invention may further include at least one extract selected from the group consisting of broccoli extract and kelp extract in order to further maximize the effect of hair growth and anti-inflammatory in addition to the kohlrabi extract. The broccoli extract and kohlrabi sprout extract is preferably added in a weight ratio of 1: 0.5 ~ 1: 0.8.

In this example, the kohlrabi extract and broccoli extract was used for each shoot. The kohlrabi sprout extract was sterilized by solvent extraction with an aqueous 70% ethanol solution, concentrated and dried to prepare a powder. Broccoli sprout extract was prepared by washing the broccoli sprout, dried and pulverized, solvent extraction with 70% ethanol aqueous solution at 40 ° C., sterilization, concentration and drying. Kelp extract was washed with seaweed, dried and pulverized, extracted with hot water at 60 ° C. for one day, filtered through a membrane of 0.45 μm, sterilized, concentrated and spray dried to prepare a powder.

Effect of Complex Extracts on Hair Growth

γ-Glutamyl transpeptidase activity measurement

The effect of Kolbi sprout extract, broccoli sprout extract, and kelp extract alone or mixture on the activity of γ-glutamyl transpeptidase (γ-GTP) was investigated. γ-GTP is an important enzyme for hair growth known to function in the hair follicles to induce hair follicles into the anagen. Depending on the experimental conditions, each extract was administered orally to mice alone or mixed for 14 days, and γ-GTP activity in the skin of the mice was measured.

In the case of treatment of the kohlrabi sprout extract, broccoli sprout extract, and kelp extracts alone, the γGTP activity tended to increase compared to the control (Normal). On the other hand, when administered together with the kohlrabi sprout extract and broccoli sprout extract (collabi + broccoli) showed a statistically significant increase in γGTP activity compared to the control. In addition, when a complex extract (composite composition 1 and 2) containing all of alfalfa sprout extract, kohlrabi sprout extract, broccoli sprout extract, cystane tubulosa extract, and kelp extract, each of the single extract or alfalfa sprout extract, cola It showed the most excellent effect of increasing the γGTP activity than the rain sprout extract, broccoli sprout extract composition. In particular, compared to the existing hair regrowth minoxidil (Minoxidil, 3%) showed a similar level.

The above experimental results have the effect of increasing the γGTP activity in the mixed composition of the kohlrabi sprout extract, especially if the broccoli sprout extract, kelp extract is further included in the kohlrabi sprout extract to maximize the γGTP activity due to the synergistic effect of the extract mixture I can see

Hair Regrowth Composition Preparation

Example 1

Black sesame powder 20%, kelp powder 10% by weight, seaweed powder 5% by weight, sewage powder 7% by weight, walnut powder 4% by weight, 15% by weight of Triton-X as a scalp penetrant, broccoli extract 2.0% by weight %, Kohlrabi sprout extract 1.2% by weight, alkylphenol ethoxylate 3% by weight, N- methacryloxy-N- carboxymetalpiperidine and 38% by weight of purified water in a solvent and then mixed for 30 minutes Stirring prepared the hair repellent composition.

Example 2

Black sesame powder 21%, kelp powder 11% by weight, seaweed powder 4% by weight, sewage powder 6% by weight, walnut powder 4% by weight, 15% by weight of Triton-X as a scalp penetrant, broccoli extract 2.0% by weight %, Kolabi sprout extract 1.8% by weight, alkylphenol ethoxylate 3% by weight, N-methacryloxy-N-carboxymetalpiperidine and 38% by weight of purified water in a solvent, and then 30 minutes Stirring prepared the hair repellent composition.

Example 3

Black sesame powder 22%, kelp powder 10% by weight, seaweed powder 5% by weight, sewage powder 7% by weight, walnut powder 4% by weight, 15% by weight of Triton-X as a scalp penetration agent, 2.5% by weight broccoli extract %, Kohlrabi sprout extract 1.0% by weight, alkylphenol ethoxylate 3% by weight, N- methacryloxy-N-carboxymetal piperidine and 38% by weight of purified water in a solvent, and then mixed for 30 minutes Stirring prepared the hair repellent composition.

Example 4

Black sesame powder 20%, kelp powder 10% by weight, brown seaweed powder 5% by weight, sewage powder 7% by weight, walnut powder 4% by weight, 15% by weight of Triton-X as a scalp penetration agent, 3.0% broccoli extract %, Kolabi sprout extract 1.7% by weight, alkylphenol ethoxylate 3% by weight, N-methacryloxy-N-carboxymetalpiperidine and 38% by weight of purified water in a solvent, followed by 30 minutes Stirring prepared the hair repellent composition.

Example 5

Black sesame powder 20%, kelp powder 10% by weight, brown seaweed powder 5% by weight, sewage powder 7% by weight, walnut powder 4% by weight, 15% by weight of Triton-X as a scalp penetration agent, 3.0% broccoli extract %, Kolavi sprout extract 1.85% by weight, alkylphenol ethoxylate 3% by weight, N-methacryloxy-N-carboxymetal piperidine and 38% by weight of purified water in a solvent, and then mixed for 30 minutes Stirring prepared the hair repellent composition.

Comparative Example 1

22% by weight of black sesame powder, 11% by weight of kelp powder, 6% by weight of seaweed powder, 8% by weight of sewage powder, 5% by weight of walnut powder, 15% by weight of dimethyl sulfoxide as scalp penetrant and 33% by weight of purified water as solvent After mixing the%, stirring for 30 minutes to prepare a hair restorer composition.

Comparative Example 2

Black sesame powder 22%, kelp powder 12% by weight, seaweed powder 8% by weight, sewage powder 9% by weight, walnut powder 5% by weight, 15% by weight of dimethyl sulfoxide as a scalp penetration agent, 1.0% by weight of collagen extract And after mixing 28% by weight of purified water with a solvent, and stirred for 30 minutes to prepare a hair restorer composition.

Property evaluation

Table 1 shows the measurement results for the hair growth promoting efficacy test for the hair regrowth composition prepared according to Examples 1 to 5 and Comparative Examples 1 to 2.

Sixty-week-old mouse males were acclimated for seven days in a laboratory at a temperature of 22 ° C. and a relative humidity of 50%, and then only 35 healthy mouse males were selected and used for testing. Distilled water was freely consumed as drinking water and experimental animal feed was freely consumed as feed. The selected male males were divided into seven groups of five by randomly selecting them, placed in a partition, and completely removed the back hair from the back of the neck to the tail. After 1 day of depilation, 10 ml of the hair repellent composition prepared according to Examples 1 to 5 and Comparative Examples 1 to 2 were applied to 5 mouse males distributed in 7 groups using a cotton swab, etc. Apply evenly.

At this time, after 15 days and 30 days of application, the hairs of the male males were 2cm behind the neck, and the center of the back.

division After 15 days After 30 days Hair thickness (㎛) Hair length (mm) Hair thickness (㎛) Hair length (mm) Example 1 38.5 7.1 60.5 17.1 Example 2 42.4 8.2 65.4 18.2 Example 3 44.3 9.3 70.2 19.3 Example 4 50.8 11.7 80.6 21.7 Example 5 55.3 14.5 84.2 25.3 Comparative Example 1 25.6 5.1 38.2 9.8 Comparative Example 2 29.5 5.9 41.2 10.1

As shown in Table 1, when applying the composition prepared according to Examples 1 to 5, it can be seen that a great effect on the hair thickness and hair length over time.

On the other hand, when applying the hair regrowth composition prepared according to Comparative Examples 1 to 2 it can be confirmed that there is no significant change in hair thickness and hair length.

As can be seen based on the above experimental results, it was confirmed that the hair growth promoting effect when using the hair regrowth composition prepared according to Examples 1 to 5. Particularly, in Example 4, a composition comprising 3.0 wt% broccoli extract and 1.7 wt% of kohlrabi sprout extract was carried out, and in Example 5, when the broccoli extract 3.0 wt% and the kohlrabi sprout extract 1.85 wt% were used, the effect was more excellent. You can see that there is.

As such, the broccoli extract and the kohlrabi sprout extract is preferably added in a weight ratio of 1: 0.5 to 1: 0.8, and more preferably the broccoli extract and the kohlrabi sprout extract are added in a weight ratio of 1: 0.61. .

In the above description, all elements constituting the embodiments of the present invention are described as being combined or operating in combination, but the present invention is not necessarily limited to the embodiments. In other words, within the scope of the present invention, all of the components may be selectively operated in combination with one or more. In addition, the terms such as 'comprise', 'comprise' or 'having' described above mean that a corresponding component may be included unless specifically stated otherwise, and thus, other components are excluded. It should be construed that it may further include other components instead. All terms, including technical and scientific terms, have the same meaning as commonly understood by one of ordinary skill in the art unless otherwise defined. Terms used generally, such as terms defined in a dictionary, should be interpreted to coincide with the contextual meaning of the related art, and shall not be interpreted in an ideal or excessively formal sense unless explicitly defined in the present invention.

The above description is merely illustrative of the technical idea of the present invention, and those skilled in the art to which the present invention pertains may make various modifications and changes without departing from the essential characteristics of the present invention. Therefore, the embodiments disclosed in the present invention are not intended to limit the technical idea of the present invention but to describe the present invention, and the scope of the technical idea of the present invention is not limited by these embodiments. The protection scope of the present invention should be interpreted by the following claims, and all technical ideas within the equivalent scope should be interpreted as being included in the scope of the present invention.

Claims (4)

Black sesame powder 20%, kelp powder 10% by weight, brown seaweed powder 5% by weight, sewage powder 7% by weight, walnut powder 4% by weight, scalp penetration agent Triton-X 15% by weight, broccoli extract 3.0% by weight , 1.85% by weight of kohlrabi sprout extract, 3% by weight of alkyl phenol ethoxylate, 3% by weight of N-methacryloxy-N-carboxymetal piperidine and 38% by weight of purified water. delete delete delete