KR102004552B1 - 도데실 2-(n,n-다이메틸아미노)-프로피오네이트의 활성 거울상체 - Google Patents

도데실 2-(n,n-다이메틸아미노)-프로피오네이트의 활성 거울상체 Download PDF

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KR102004552B1
KR102004552B1 KR1020137013227A KR20137013227A KR102004552B1 KR 102004552 B1 KR102004552 B1 KR 102004552B1 KR 1020137013227 A KR1020137013227 A KR 1020137013227A KR 20137013227 A KR20137013227 A KR 20137013227A KR 102004552 B1 KR102004552 B1 KR 102004552B1
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South Korea
Prior art keywords
acid addition
addition salt
dimethylamino
dodecyl
propionate
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KR1020137013227A
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Korean (ko)
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KR20140023875A (ko
Inventor
바삼 비. 다마
리차드 마틴
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넥스메드 홀딩스 인코포레이티드
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A61K31/221—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin with compounds having an amino group, e.g. acetylcholine, acetylcarnitine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/06—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Emergency Medicine (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
KR1020137013227A 2010-12-02 2011-11-30 도데실 2-(n,n-다이메틸아미노)-프로피오네이트의 활성 거울상체 Expired - Fee Related KR102004552B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US41899610P 2010-12-02 2010-12-02
US61/418,996 2010-12-02
PCT/US2011/062579 WO2012075107A2 (en) 2010-12-02 2011-11-30 Active enantiomer of dodecyl 2-(n,n-dimethylamino)-propionate

Publications (2)

Publication Number Publication Date
KR20140023875A KR20140023875A (ko) 2014-02-27
KR102004552B1 true KR102004552B1 (ko) 2019-10-01

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KR1020137013227A Expired - Fee Related KR102004552B1 (ko) 2010-12-02 2011-11-30 도데실 2-(n,n-다이메틸아미노)-프로피오네이트의 활성 거울상체

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US (1) US20130267562A1 (enExample)
EP (1) EP2646015B1 (enExample)
JP (1) JP6109075B2 (enExample)
KR (1) KR102004552B1 (enExample)
CN (1) CN103930105B (enExample)
AU (2) AU2011336692B2 (enExample)
BR (1) BR112013012799A8 (enExample)
CA (1) CA2817417C (enExample)
CL (1) CL2013001391A1 (enExample)
CR (1) CR20130324A (enExample)
ES (1) ES2801999T3 (enExample)
IL (1) IL226173A (enExample)
MX (1) MX2013005522A (enExample)
NZ (1) NZ609826A (enExample)
PH (1) PH12013501104A1 (enExample)
PL (1) PL2646015T3 (enExample)
RU (1) RU2679308C2 (enExample)
SG (2) SG10201803321TA (enExample)
WO (1) WO2012075107A2 (enExample)
ZA (1) ZA201304840B (enExample)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014028780A2 (en) * 2012-08-15 2014-02-20 Nexmed Holdings, Inc. Antifungal compounds and methods of use
US8900625B2 (en) 2012-12-15 2014-12-02 Nexmed Holdings, Inc. Antimicrobial compounds and methods of use

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6118020A (en) * 1999-05-19 2000-09-12 Nexmed Holdings, Inc. Crystalline salts of dodecyl 2-(N,N-dimethylamino)-propionate
US6323241B1 (en) * 2000-01-10 2001-11-27 Nexmed (Holdings) Inc. Prostaglandin compositions and methods of treatment for male erectile dysfunction
DE10033853A1 (de) * 2000-07-12 2002-01-31 Hexal Ag Transdermales therapeutisches System mit hochdispersem Siliziumdioxid
JP5160018B2 (ja) * 2002-06-25 2013-03-13 アクルックス・ディ・ディ・エス・プロプライエタリー・リミテッド 非晶質医薬組成物を用いる経皮送達速度調節
US20050181030A1 (en) * 2003-01-03 2005-08-18 Mo Y. J. Topical stabilized prostaglandin E compound dosage forms
EP1635770B1 (en) * 2003-03-21 2009-05-27 Nexmed Holdings, Inc. Antifungal nail coat and method of use
WO2005009510A2 (en) * 2003-07-23 2005-02-03 The Regents Of The University Of California Penetration enhancer combinations for transdermal delivery
PL1670433T3 (pl) * 2003-10-10 2013-03-29 Ferring Bv Przezskórna formulacja farmaceutyczna do zmniejszania pozostałości na skórze
WO2005051960A2 (en) * 2003-11-22 2005-06-09 Midwest Research Laboratories, Llc Hydrocarbyl aminohydrocarbonoates and aminohydrocarbonol hydrocarbonoates as antimicrobial and antiviral agents
RU2012153177A (ru) * 2010-05-04 2014-06-20 Нексмед Холдингс, Инк. Композиции низкомолекулярных терапевтических средств
US8900625B2 (en) * 2012-12-15 2014-12-02 Nexmed Holdings, Inc. Antimicrobial compounds and methods of use

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
Pharmaceutical Research, 1994, vol. 11(2), pp.288-294.*
Pharmaceutical Research, 2009, vol. 26(4), pp.811-821.*

Also Published As

Publication number Publication date
SG10201803321TA (en) 2018-06-28
ES2801999T3 (es) 2021-01-15
BR112013012799A8 (pt) 2018-01-09
CN103930105A (zh) 2014-07-16
AU2011336692B2 (en) 2017-02-16
KR20140023875A (ko) 2014-02-27
AU2017200314A1 (en) 2017-02-02
MX2013005522A (es) 2013-07-17
CA2817417C (en) 2020-12-29
SG190199A1 (en) 2013-06-28
CL2013001391A1 (es) 2013-11-08
US20130267562A1 (en) 2013-10-10
PL2646015T3 (pl) 2020-11-30
EP2646015A2 (en) 2013-10-09
RU2679308C2 (ru) 2019-02-07
CR20130324A (es) 2013-08-13
BR112013012799A2 (pt) 2016-09-13
WO2012075107A2 (en) 2012-06-07
CN103930105B (zh) 2019-11-01
WO2012075107A3 (en) 2014-03-06
RU2013119439A (ru) 2015-01-10
JP6109075B2 (ja) 2017-04-05
IL226173A (en) 2016-10-31
NZ609826A (en) 2016-03-31
JP2014514243A (ja) 2014-06-19
ZA201304840B (en) 2014-04-30
EP2646015A4 (en) 2015-04-08
EP2646015B1 (en) 2020-04-22
AU2011336692A1 (en) 2013-05-30
IL226173A0 (en) 2013-07-31
PH12013501104A1 (en) 2013-07-08
CA2817417A1 (en) 2012-06-07

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