AU2011336692B2 - Active enantiomer of dodecyl 2-(N,N-dimethylamino)-propionate - Google Patents

Active enantiomer of dodecyl 2-(N,N-dimethylamino)-propionate Download PDF

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Publication number
AU2011336692B2
AU2011336692B2 AU2011336692A AU2011336692A AU2011336692B2 AU 2011336692 B2 AU2011336692 B2 AU 2011336692B2 AU 2011336692 A AU2011336692 A AU 2011336692A AU 2011336692 A AU2011336692 A AU 2011336692A AU 2011336692 B2 AU2011336692 B2 AU 2011336692B2
Authority
AU
Australia
Prior art keywords
dimethylamino
propionate
dodecyl
enantiomeric purity
active compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2011336692A
Other languages
English (en)
Other versions
AU2011336692A1 (en
Inventor
Bassam B. Damaj
Richard Martin
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ferring International Center SA
Original Assignee
Ferring International Center SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ferring International Center SA filed Critical Ferring International Center SA
Publication of AU2011336692A1 publication Critical patent/AU2011336692A1/en
Priority to AU2017200314A priority Critical patent/AU2017200314A1/en
Application granted granted Critical
Publication of AU2011336692B2 publication Critical patent/AU2011336692B2/en
Assigned to FERRING INTERNATIONAL CENTER S.A. reassignment FERRING INTERNATIONAL CENTER S.A. Request for Assignment Assignors: NEXMED HOLDINGS, INC.
Ceased legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
    • A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A61K31/221—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin with compounds having an amino group, e.g. acetylcholine, acetylcarnitine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/06—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Emergency Medicine (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
AU2011336692A 2010-12-02 2011-11-30 Active enantiomer of dodecyl 2-(N,N-dimethylamino)-propionate Ceased AU2011336692B2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2017200314A AU2017200314A1 (en) 2010-12-02 2017-01-17 Active enantiomer of dodecyl 2-(N,N-dimethylamino)-propionate

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US41899610P 2010-12-02 2010-12-02
US61/418,996 2010-12-02
PCT/US2011/062579 WO2012075107A2 (en) 2010-12-02 2011-11-30 Active enantiomer of dodecyl 2-(n,n-dimethylamino)-propionate

Related Child Applications (1)

Application Number Title Priority Date Filing Date
AU2017200314A Division AU2017200314A1 (en) 2010-12-02 2017-01-17 Active enantiomer of dodecyl 2-(N,N-dimethylamino)-propionate

Publications (2)

Publication Number Publication Date
AU2011336692A1 AU2011336692A1 (en) 2013-05-30
AU2011336692B2 true AU2011336692B2 (en) 2017-02-16

Family

ID=46172526

Family Applications (2)

Application Number Title Priority Date Filing Date
AU2011336692A Ceased AU2011336692B2 (en) 2010-12-02 2011-11-30 Active enantiomer of dodecyl 2-(N,N-dimethylamino)-propionate
AU2017200314A Abandoned AU2017200314A1 (en) 2010-12-02 2017-01-17 Active enantiomer of dodecyl 2-(N,N-dimethylamino)-propionate

Family Applications After (1)

Application Number Title Priority Date Filing Date
AU2017200314A Abandoned AU2017200314A1 (en) 2010-12-02 2017-01-17 Active enantiomer of dodecyl 2-(N,N-dimethylamino)-propionate

Country Status (20)

Country Link
US (1) US20130267562A1 (enExample)
EP (1) EP2646015B1 (enExample)
JP (1) JP6109075B2 (enExample)
KR (1) KR102004552B1 (enExample)
CN (1) CN103930105B (enExample)
AU (2) AU2011336692B2 (enExample)
BR (1) BR112013012799A8 (enExample)
CA (1) CA2817417C (enExample)
CL (1) CL2013001391A1 (enExample)
CR (1) CR20130324A (enExample)
ES (1) ES2801999T3 (enExample)
IL (1) IL226173A (enExample)
MX (1) MX2013005522A (enExample)
NZ (1) NZ609826A (enExample)
PH (1) PH12013501104A1 (enExample)
PL (1) PL2646015T3 (enExample)
RU (1) RU2679308C2 (enExample)
SG (2) SG10201803321TA (enExample)
WO (1) WO2012075107A2 (enExample)
ZA (1) ZA201304840B (enExample)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2014028780A2 (en) * 2012-08-15 2014-02-20 Nexmed Holdings, Inc. Antifungal compounds and methods of use
US8900625B2 (en) 2012-12-15 2014-12-02 Nexmed Holdings, Inc. Antimicrobial compounds and methods of use

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6118020A (en) * 1999-05-19 2000-09-12 Nexmed Holdings, Inc. Crystalline salts of dodecyl 2-(N,N-dimethylamino)-propionate
US6323241B1 (en) * 2000-01-10 2001-11-27 Nexmed (Holdings) Inc. Prostaglandin compositions and methods of treatment for male erectile dysfunction
DE10033853A1 (de) * 2000-07-12 2002-01-31 Hexal Ag Transdermales therapeutisches System mit hochdispersem Siliziumdioxid
JP5160018B2 (ja) * 2002-06-25 2013-03-13 アクルックス・ディ・ディ・エス・プロプライエタリー・リミテッド 非晶質医薬組成物を用いる経皮送達速度調節
US20050181030A1 (en) * 2003-01-03 2005-08-18 Mo Y. J. Topical stabilized prostaglandin E compound dosage forms
EP1635770B1 (en) * 2003-03-21 2009-05-27 Nexmed Holdings, Inc. Antifungal nail coat and method of use
WO2005009510A2 (en) * 2003-07-23 2005-02-03 The Regents Of The University Of California Penetration enhancer combinations for transdermal delivery
PL1670433T3 (pl) * 2003-10-10 2013-03-29 Ferring Bv Przezskórna formulacja farmaceutyczna do zmniejszania pozostałości na skórze
WO2005051960A2 (en) * 2003-11-22 2005-06-09 Midwest Research Laboratories, Llc Hydrocarbyl aminohydrocarbonoates and aminohydrocarbonol hydrocarbonoates as antimicrobial and antiviral agents
RU2012153177A (ru) * 2010-05-04 2014-06-20 Нексмед Холдингс, Инк. Композиции низкомолекулярных терапевтических средств
US8900625B2 (en) * 2012-12-15 2014-12-02 Nexmed Holdings, Inc. Antimicrobial compounds and methods of use

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Pharmaceutical Research, 2009, vol. 26, no. 4, pp. 811-821 *

Also Published As

Publication number Publication date
SG10201803321TA (en) 2018-06-28
ES2801999T3 (es) 2021-01-15
BR112013012799A8 (pt) 2018-01-09
CN103930105A (zh) 2014-07-16
KR20140023875A (ko) 2014-02-27
AU2017200314A1 (en) 2017-02-02
MX2013005522A (es) 2013-07-17
CA2817417C (en) 2020-12-29
SG190199A1 (en) 2013-06-28
CL2013001391A1 (es) 2013-11-08
US20130267562A1 (en) 2013-10-10
KR102004552B1 (ko) 2019-10-01
PL2646015T3 (pl) 2020-11-30
EP2646015A2 (en) 2013-10-09
RU2679308C2 (ru) 2019-02-07
CR20130324A (es) 2013-08-13
BR112013012799A2 (pt) 2016-09-13
WO2012075107A2 (en) 2012-06-07
CN103930105B (zh) 2019-11-01
WO2012075107A3 (en) 2014-03-06
RU2013119439A (ru) 2015-01-10
JP6109075B2 (ja) 2017-04-05
IL226173A (en) 2016-10-31
NZ609826A (en) 2016-03-31
JP2014514243A (ja) 2014-06-19
ZA201304840B (en) 2014-04-30
EP2646015A4 (en) 2015-04-08
EP2646015B1 (en) 2020-04-22
AU2011336692A1 (en) 2013-05-30
IL226173A0 (en) 2013-07-31
PH12013501104A1 (en) 2013-07-08
CA2817417A1 (en) 2012-06-07

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Legal Events

Date Code Title Description
PC1 Assignment before grant (sect. 113)

Owner name: FERRING INTERNATIONAL CENTER S.A.

Free format text: FORMER APPLICANT(S): NEXMED HOLDINGS, INC.

FGA Letters patent sealed or granted (standard patent)
MK14 Patent ceased section 143(a) (annual fees not paid) or expired