MX2013005522A - Enantiomero activo de dodecil-2-(n,n-dimetilamino)-propionato. - Google Patents
Enantiomero activo de dodecil-2-(n,n-dimetilamino)-propionato.Info
- Publication number
- MX2013005522A MX2013005522A MX2013005522A MX2013005522A MX2013005522A MX 2013005522 A MX2013005522 A MX 2013005522A MX 2013005522 A MX2013005522 A MX 2013005522A MX 2013005522 A MX2013005522 A MX 2013005522A MX 2013005522 A MX2013005522 A MX 2013005522A
- Authority
- MX
- Mexico
- Prior art keywords
- dimethylamino
- propionate
- dodecyl
- ddaip
- active enantiomer
- Prior art date
Links
- HSMMSDWNEJLVRY-INIZCTEOSA-N dodecyl (2s)-2-(dimethylamino)propanoate Chemical compound CCCCCCCCCCCCOC(=O)[C@H](C)N(C)C HSMMSDWNEJLVRY-INIZCTEOSA-N 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 1
- 239000012528 membrane Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
- A61K31/221—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin with compounds having an amino group, e.g. acetylcholine, acetylcarnitine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C229/06—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one amino and one carboxyl group bound to the carbon skeleton
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Emergency Medicine (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
El 2R-dodecil 2-(N,N-dimetilamino)propionato (R-DDAIP) proporciona una actividad mejorada inesperada en la facilitación del transporte de un compuesto farmacéuticamente activo a través de membranas y tejidos biológicos, en comparación con el S-DDAIP de la misma pureza enantiomérica, o el DDAIP racémico. También se proporciona el S-DDAIP purificado.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US41899610P | 2010-12-02 | 2010-12-02 | |
PCT/US2011/062579 WO2012075107A2 (en) | 2010-12-02 | 2011-11-30 | Active enantiomer of dodecyl 2-(n,n-dimethylamino)-propionate |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2013005522A true MX2013005522A (es) | 2013-07-17 |
Family
ID=46172526
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2013005522A MX2013005522A (es) | 2010-12-02 | 2011-11-30 | Enantiomero activo de dodecil-2-(n,n-dimetilamino)-propionato. |
Country Status (19)
Country | Link |
---|---|
US (1) | US20130267562A1 (es) |
EP (1) | EP2646015B1 (es) |
JP (1) | JP6109075B2 (es) |
KR (1) | KR102004552B1 (es) |
CN (1) | CN103930105B (es) |
AU (2) | AU2011336692B2 (es) |
BR (1) | BR112013012799A8 (es) |
CA (1) | CA2817417C (es) |
CL (1) | CL2013001391A1 (es) |
CR (1) | CR20130324A (es) |
ES (1) | ES2801999T3 (es) |
IL (1) | IL226173A (es) |
MX (1) | MX2013005522A (es) |
NZ (1) | NZ609826A (es) |
PL (1) | PL2646015T3 (es) |
RU (1) | RU2679308C2 (es) |
SG (2) | SG190199A1 (es) |
WO (1) | WO2012075107A2 (es) |
ZA (1) | ZA201304840B (es) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2014028780A2 (en) * | 2012-08-15 | 2014-02-20 | Nexmed Holdings, Inc. | Antifungal compounds and methods of use |
US8900625B2 (en) | 2012-12-15 | 2014-12-02 | Nexmed Holdings, Inc. | Antimicrobial compounds and methods of use |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6118020A (en) * | 1999-05-19 | 2000-09-12 | Nexmed Holdings, Inc. | Crystalline salts of dodecyl 2-(N,N-dimethylamino)-propionate |
US6323241B1 (en) * | 2000-01-10 | 2001-11-27 | Nexmed (Holdings) Inc. | Prostaglandin compositions and methods of treatment for male erectile dysfunction |
DE10033853A1 (de) * | 2000-07-12 | 2002-01-31 | Hexal Ag | Transdermales therapeutisches System mit hochdispersem Siliziumdioxid |
KR20050045946A (ko) * | 2002-06-25 | 2005-05-17 | 애크럭스 디디에스 피티와이 리미티드 | 비정질 약학적 조성물을 이용한 경피전달속도의 제어 |
US20050181030A1 (en) * | 2003-01-03 | 2005-08-18 | Mo Y. J. | Topical stabilized prostaglandin E compound dosage forms |
JP4540667B2 (ja) * | 2003-03-21 | 2010-09-08 | ネクスメツド・ホールデイングス・インコーポレイテツド | 抗真菌性ネイルコート |
CA2530407A1 (en) * | 2003-07-23 | 2005-02-03 | The Regents Of The University Of California | Penetration enhancer combinations for transdermal delivery |
JP5619337B2 (ja) * | 2003-10-10 | 2014-11-05 | フェリング ビー.ブイ. | 皮膚残渣を最小限に抑えるための経皮的医薬製剤 |
US20050113274A1 (en) * | 2003-11-22 | 2005-05-26 | Nadir Buyuktimkin | Hydrocarbyl aminohydrocarbonoates and aminohydrocarbonol hydrocarbonoates as antimicrobial and antiviral agents |
KR20130079382A (ko) * | 2010-05-04 | 2013-07-10 | 넥스메드 홀딩스 인코포레이티드 | 소분자 치료제의 조성물 |
US8900625B2 (en) * | 2012-12-15 | 2014-12-02 | Nexmed Holdings, Inc. | Antimicrobial compounds and methods of use |
-
2011
- 2011-11-30 JP JP2013542128A patent/JP6109075B2/ja not_active Expired - Fee Related
- 2011-11-30 EP EP11845087.3A patent/EP2646015B1/en active Active
- 2011-11-30 AU AU2011336692A patent/AU2011336692B2/en not_active Ceased
- 2011-11-30 CA CA2817417A patent/CA2817417C/en not_active Expired - Fee Related
- 2011-11-30 MX MX2013005522A patent/MX2013005522A/es unknown
- 2011-11-30 RU RU2013119439A patent/RU2679308C2/ru not_active Application Discontinuation
- 2011-11-30 US US13/991,111 patent/US20130267562A1/en not_active Abandoned
- 2011-11-30 NZ NZ609826A patent/NZ609826A/en not_active IP Right Cessation
- 2011-11-30 PL PL11845087T patent/PL2646015T3/pl unknown
- 2011-11-30 SG SG2013035258A patent/SG190199A1/en unknown
- 2011-11-30 KR KR1020137013227A patent/KR102004552B1/ko active IP Right Grant
- 2011-11-30 CN CN201180054224.5A patent/CN103930105B/zh not_active Expired - Fee Related
- 2011-11-30 ES ES11845087T patent/ES2801999T3/es active Active
- 2011-11-30 WO PCT/US2011/062579 patent/WO2012075107A2/en active Application Filing
- 2011-11-30 BR BR112013012799A patent/BR112013012799A8/pt not_active Application Discontinuation
- 2011-11-30 SG SG10201803321TA patent/SG10201803321TA/en unknown
-
2013
- 2013-05-05 IL IL226173A patent/IL226173A/en active IP Right Grant
- 2013-05-16 CL CL2013001391A patent/CL2013001391A1/es unknown
- 2013-06-26 CR CR20130324A patent/CR20130324A/es unknown
- 2013-06-28 ZA ZA2013/04840A patent/ZA201304840B/en unknown
-
2017
- 2017-01-17 AU AU2017200314A patent/AU2017200314A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
US20130267562A1 (en) | 2013-10-10 |
RU2679308C2 (ru) | 2019-02-07 |
JP6109075B2 (ja) | 2017-04-05 |
IL226173A0 (en) | 2013-07-31 |
SG190199A1 (en) | 2013-06-28 |
CN103930105B (zh) | 2019-11-01 |
KR102004552B1 (ko) | 2019-10-01 |
ES2801999T3 (es) | 2021-01-15 |
IL226173A (en) | 2016-10-31 |
KR20140023875A (ko) | 2014-02-27 |
CR20130324A (es) | 2013-08-13 |
AU2017200314A1 (en) | 2017-02-02 |
SG10201803321TA (en) | 2018-06-28 |
EP2646015A2 (en) | 2013-10-09 |
CL2013001391A1 (es) | 2013-11-08 |
NZ609826A (en) | 2016-03-31 |
WO2012075107A3 (en) | 2014-03-06 |
BR112013012799A2 (pt) | 2016-09-13 |
CA2817417A1 (en) | 2012-06-07 |
AU2011336692A1 (en) | 2013-05-30 |
BR112013012799A8 (pt) | 2018-01-09 |
CN103930105A (zh) | 2014-07-16 |
ZA201304840B (en) | 2014-04-30 |
WO2012075107A2 (en) | 2012-06-07 |
EP2646015A4 (en) | 2015-04-08 |
AU2011336692B2 (en) | 2017-02-16 |
JP2014514243A (ja) | 2014-06-19 |
PL2646015T3 (pl) | 2020-11-30 |
EP2646015B1 (en) | 2020-04-22 |
CA2817417C (en) | 2020-12-29 |
RU2013119439A (ru) | 2015-01-10 |
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