KR101999299B1 - 팬턴-발렌타인 류코시딘(pvl) 유래 폴리펩티드를 포함하는 면역원성 조성물 - Google Patents

팬턴-발렌타인 류코시딘(pvl) 유래 폴리펩티드를 포함하는 면역원성 조성물 Download PDF

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KR101999299B1
KR101999299B1 KR1020147018356A KR20147018356A KR101999299B1 KR 101999299 B1 KR101999299 B1 KR 101999299B1 KR 1020147018356 A KR1020147018356 A KR 1020147018356A KR 20147018356 A KR20147018356 A KR 20147018356A KR 101999299 B1 KR101999299 B1 KR 101999299B1
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KR20140117381A (ko
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모함마드 자바드 아만
라잔 프라사드 아디카리
하티스 카라우줌
자와드 사와르
세르게이 슐레닌
사티야 벤카타라마니
켈리 린 워필드
탐 루옹 뉴옌
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인티그레이티드 바이오쎄라퓨틱스, 인크.
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P37/02—Immunomodulators
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/305—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Micrococcaceae (F)
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/12—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from bacteria
    • C07K16/1267—Gram-positive bacteria
    • C07K16/1271—Micrococcaceae (F); Staphylococcaceae (F), e.g. Staphylococcus (G)
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against enzymes
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    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55505—Inorganic adjuvants
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55561—CpG containing adjuvants; Oligonucleotide containing adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55566—Emulsions, e.g. Freund's adjuvant, MF59

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  • Peptides Or Proteins (AREA)
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  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
KR1020147018356A 2011-12-02 2012-11-30 팬턴-발렌타인 류코시딘(pvl) 유래 폴리펩티드를 포함하는 면역원성 조성물 Active KR101999299B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201161566234P 2011-12-02 2011-12-02
US61/566,234 2011-12-02
PCT/US2012/067483 WO2013082558A1 (en) 2011-12-02 2012-11-30 Immunogenic composition comprising panton-valentine leukocidin (pvl) derived polypeptides

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KR20140117381A KR20140117381A (ko) 2014-10-07
KR101999299B1 true KR101999299B1 (ko) 2019-07-12

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KR1020147018356A Active KR101999299B1 (ko) 2011-12-02 2012-11-30 팬턴-발렌타인 류코시딘(pvl) 유래 폴리펩티드를 포함하는 면역원성 조성물

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US (1) US10023848B2 (https=)
EP (1) EP2785368B1 (https=)
JP (1) JP6325452B2 (https=)
KR (1) KR101999299B1 (https=)
AU (1) AU2012345645B2 (https=)
CA (1) CA2857666C (https=)
DK (1) DK2785368T3 (https=)
ES (1) ES2728445T3 (https=)
HR (1) HRP20190907T1 (https=)
LT (1) LT2785368T (https=)
RS (1) RS58919B1 (https=)
SI (1) SI2785368T1 (https=)
WO (1) WO2013082558A1 (https=)

Families Citing this family (12)

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Publication number Priority date Publication date Assignee Title
DK2785368T3 (da) 2011-12-02 2019-05-27 Integrated Biotherapeutics Inc Immunogen sammensætning, der omfatter panton-valentine-leukocidin (pvl)-afledte polypeptider
WO2014205127A2 (en) 2013-06-18 2014-12-24 New York University Cellular factors involved in the cytotoxicity of staphylococcus aureus leukocidins: novel therapeutic targets
PT3010535T (pt) 2013-06-19 2020-07-03 Integrated Biotherapeutics Inc Péptidos de toxoide derivados de modulina solúvel em fenol, delta toxina, superantigénios e suas fusões
US9149522B2 (en) 2013-09-25 2015-10-06 Sequoia Sciences, Inc. Compositions of vaccines and adjuvants and methods for the treatment of urinary tract infections
US20150086592A1 (en) 2013-09-25 2015-03-26 Sequoia Sciences, Inc Compositions of vaccines and adjuvants and methods for the treatment of urinary tract infections
US9149521B2 (en) 2013-09-25 2015-10-06 Sequoia Sciences, Inc. Compositions of vaccines and adjuvants and methods for the treatment of urinary tract infections
US9504743B2 (en) 2013-09-25 2016-11-29 Sequoia Sciences, Inc Compositions of vaccines and adjuvants and methods for the treatment of urinary tract infections
EP3057989A1 (en) * 2013-10-17 2016-08-24 ARSANIS Biosciences GmbH Cross-reactive staphylococcus aureus antibody sequences
WO2017026301A1 (ja) * 2015-08-10 2017-02-16 株式会社微生物化学研究所 黄色ブドウ球菌不活化菌体とロイコシジンを混合したワクチン
CN107224575B (zh) * 2017-03-06 2018-11-09 浙江海隆生物科技有限公司 奶牛金黄色葡萄球菌乳房炎亚单位疫苗的组合物及其制备方法和应用
WO2019023341A1 (en) 2017-07-27 2019-01-31 Integrated Biotherapeutics, Inc. IMMUNOGENIC COMPOSITION COMPRISING A MELTING PEPTIDE DERIVED FROM TOXOIDS OF SUPERANTIGENES
WO2025085539A1 (en) * 2023-10-16 2025-04-24 The Trustees Of Columbia University In The City Of New York Engineered bacteria for cellular barrier maintenance and protection

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US4683195A (en) 1986-01-30 1987-07-28 Cetus Corporation Process for amplifying, detecting, and/or-cloning nucleic acid sequences
US5874064A (en) 1996-05-24 1999-02-23 Massachusetts Institute Of Technology Aerodynamically light particles for pulmonary drug delivery
US20100158871A1 (en) 1999-08-30 2010-06-24 David Stephen Terman Sickled erythrocytes with antitumor molecules induce tumoricidal effects
US20050008633A1 (en) 2003-05-19 2005-01-13 Advanced Inhalation Research Inc. Chemical and physical modulators of bioavailability of inhaled compositions
TWI374892B (en) * 2005-06-13 2012-10-21 Glaxosmithkline Biolog Sa Use of panton-valentine leukocidin for treating and preventing staphylococcus infections
US7754225B2 (en) 2006-07-20 2010-07-13 Glaxosmithkline Biologicals S.A. Method of protecting against staphylococcal infection
JP5183635B2 (ja) * 2006-10-18 2013-04-17 ビオメリュー Ｐｖｌ産生黄色ブドウ球菌のインビトロにおける診断方法
DK2785368T3 (da) 2011-12-02 2019-05-27 Integrated Biotherapeutics Inc Immunogen sammensætning, der omfatter panton-valentine-leukocidin (pvl)-afledte polypeptider

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GUILLET VALERIE 등, J Biol Chem, vol. 279, no. 39, p.41028-41037 (2004.09.24.)
M. Javad Aman 등, Journal of Biomolecular Structure & Dynamics, Vol.28, No.1, p.1-12 (2010)

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SI2785368T1 (sl) 2019-08-30
CA2857666A1 (en) 2013-06-06
LT2785368T (lt) 2019-06-10
RS58919B1 (sr) 2019-08-30
JP2015505831A (ja) 2015-02-26
NZ626762A (en) 2016-07-29
EP2785368B1 (en) 2019-03-13
EP2785368A4 (en) 2015-12-30
KR20140117381A (ko) 2014-10-07
DK2785368T3 (da) 2019-05-27
CA2857666C (en) 2020-08-11
US20140308291A1 (en) 2014-10-16
EP2785368A1 (en) 2014-10-08
HRP20190907T1 (hr) 2019-07-12
WO2013082558A1 (en) 2013-06-06
JP6325452B2 (ja) 2018-05-16
US10023848B2 (en) 2018-07-17
AU2012345645A1 (en) 2014-06-26
AU2012345645B2 (en) 2017-09-07
ES2728445T3 (es) 2019-10-24

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