KR101985530B1 - Composition for improving sleep comprising natural herbal medicine materials - Google Patents

Abstract

The present invention relates to a composition for inducing sound sleep comprising natural herbal medicine components. The present invention includes an oriental medicine fragrance composition, wherein the oriental medicine fragrance composition can include an herbal medicine extract selected from the group consisting of Zizyphus jujuba, Poria cocos (Schw.), Cnidium officinale Makino, Polygala tenuifolia and mixtures thereof. The composition for inducing sound sleep comprising the natural herbal medicine components, by using the fragrance remaining in the mouth, can enhance the efficiency of inducing sound sleep and provide a composition for inducing sound sleep which lasts long.

Description

TECHNICAL FIELD [0001] The present invention relates to a composition for inducing sleep in a human body,

The present invention relates to a composition for inducing sleeping appearance comprising a natural herbal medicine ingredient. More particularly, the present invention relates to a composition for inducing a sleeping face comprising a natural herbal medicine component using a directionality remaining in the oral cavity by a natural herbal medicine ingredient.

Sleep is an important physiological function of the brain-developing animal and is an indispensable act for survival. Every creature on earth lives in the environment where the rhythm of day and night changes regularly. The most basic survival strategy in living things was to repeat the rhythm of activity and rest, synchronizing with this round change and predicting this change. Therefore, all living creatures demonstrate the behavior of building a biological clock (day clock, biological clock) and synchronizing with environmental cycles.

Sleep deprivation can lead to sleepiness, irritability, or lack of vitality, and loss of quality of life. In some cases, it may cause serious damage to life support. Sleep is a function that does not cause this condition, so taking a good night's sleep is very important.

However, it is reported that the population of insomnia in Korea reaches about 4 million. Insomnia, which can not sleep, raises the risk of death by 56% and is not a symptom that can be seen lightly.

Treatment of sleeping defects using directionality has a long history, both east and west. In the West, it has been studied that herbs such as lavender and rosemary are effective for the induction of sleeping. Distillation of these herbs is carried out by diffusing, perfume, aromatherapy And so on. In Oriental medicine as well, it has been used in various ways to help induce sleep by using the fragrance inhalation of medicinal herbs which helps to induce sleep.

On the other hand, the fragrance is a dictionary of medicines with a good fragrance. In addition, it is used to remove or replace odor or disgusting odor in a living room such as a room, an office room, a public toilet, a car interior, etc., and to obtain a sense of cleanliness or stability through fragrance. In recent years, As a result, the range has been expanded to be used for stress relieving and therapeutic effects.

Herbal medicines using these fragrances are classified in the oriental herbal medicine as "open medicine" and "new medicine", and they are used to solve various symptoms caused by gas.

This gaseous symptom is similar to various mental illnesses caused by current stress, and therefore research has been conducted to use herbal medicines for such mental disorders.

More specifically, the aromatherapy of western medicine is applied to the mechanism of the body by using the aroma coming into the body from the outside, whereas in Oriental medicine, not only the aroma of the outside but also the medicines taken are used for the treatment by acting in the body There is a difference in explanation.

The current use of aroma, which is the current mainstream, is the use of directionality coming from the outside to the inside. However, as described above, there is a problem that the sleep induction method using the perfume inhalation from the outside does not last long and is inefficient.

It is necessary to develop a composition for inducing sleeping in order to solve such a problem.

(Patent Document 1) KR10-1175656 B1 (Patent Document 2) KR 10-2010-0124620 A1

It is an object of the present invention to provide a composition for inducing sleep induction comprising a natural herbal medicine ingredient.

It is another object of the present invention to provide a composition for oral hygiene or a food composition using the composition for inducing sleep induction comprising the natural herbal medicine component to improve the efficiency of induction of the sleeping by using the fragrance remaining in the oral cavity, And to provide a thin composition for inducing sleep.

Another object of the present invention is to provide a toothpaste, oral spray, mouthwash, or chewing gum with a high degree of preference when using the composition for inducing a sleep composition containing the natural herbal medicine component.

In order to achieve the above object, the composition for inducing sleep according to one embodiment of the present invention comprises a one-way fragrance composition, wherein the one-way fragrance composition is selected from the group consisting of Zizyphus jujuba, Poria cocos (Schw.), Cnidium officinale Makino, Polygala tenuifolia, and mixtures thereof.

The herbal medicine extract may be extracted with a solvent selected from the group consisting of water, an alcohol having 1 to 6 carbon atoms, and a mixture thereof.

The composition for inducing sleep may further comprise a second herbal medicine extract selected from the group consisting of Glycyrrhiza uralensis, Pterocarpus santalinus, Coptis japonica, and mixtures thereof.

The composition for inducing sleeping can induce a good sleep by utilizing the directionality remaining in the mouth.

The oral care composition according to another embodiment of the present invention may include the composition for inducing sleep.

The toothpaste according to another embodiment of the present invention may include the oral cleaning composition.

Oral sprays according to another embodiment of the present invention may include the oral cleaning composition.

The oral cleaning agent according to another embodiment of the present invention may include the oral cleaning composition.

The composition for food according to another embodiment of the present invention may include the composition for inducing sleep.

The chewing gum composition according to another embodiment of the present invention may include a composition for the food.

Hereinafter, the present invention will be described in more detail.

A composition for inducing sleep induction comprising a herbal composition according to an embodiment of the present invention comprises a one-way fragrance composition, wherein the one-way fragrance composition is selected from the group consisting of Zizyphus jujuba, Poria cocos (Schw.), Cnidium officinale Makino, Polygala tenuifolia, and mixtures thereof.

The Zizyphus jujuba was dried from the lily of the pineapple. The taste is sweet and the quality is fair. They see the wall, stabilize their mind, help the rain function, and stop sweating. It also heals the stuffiness of the chest and strengthens the bones and muscles. It acts on the heart, the nerve, the liver, and the paralysis.

Poria cocos (Schw.) Is a sclerot of the bamboo which is a fungus belonging to the manganese gangsaceae. It is collected from July to September, and the mango is removed and sweated to remove most of the inside water and then shade it. The fresh bamboo leaves are called 'Bokryeonggo' and 'Bokryeongbyeon', and the peeled shells are called 'Bokryeongpie'. The pale pink part below the crypt layer is called 'Baekbokryeong', the white part after cutting Baekbokgyeong is called 'Baekbokryeong', and the one with pine roots in the middle is called 'Bokshin'.

The Cnidium officinale Makino is a dried rootstock of the red mackerel. 4 to 5 days after planting in the plains, cultivated in mountainous areas are collected in shoelaces to remove the leaves and beard roots, washed and dried in the sun or fire. It is also used as a substitute for the enemy. The property is warm but tastes good.

Polygala tenuifolia is dried with roots of raw paper and raw paper, it is slightly warm in nature, and taste is spicy. It has the function of helping Shenyang, eliminating intrusion, and contributing to planting. It has the function of helping the mind and body and relieving the head and clearing the head. Anxiety due to mind and body Buddhism, boundaries, face-to-face, conspicuousness, activity, feelings are effective.

In the present invention, the herbal medicine extract may be extracted with a solvent selected from the group consisting of water, an alcohol having 1 to 6 carbon atoms, and a mixed solvent thereof. The term "sanjoin extract" means an extract obtained by extracting a sanjoin. Refers to an extract obtained by extracting dsuckins. The 'astragalus extract' means the extract obtained by extracting the astragalus root. The 'original extract' refers to the extract obtained by extracting the raw paper.

The crude herb extract may be prepared by dissolving the herb extract in a polar solvent such as a C ₁ to C ₆ alcohol such as water, ethanol, methanol or the like, or a polar solvent such as a 1: 0.1 to 1:10 And can be eluted with a mixed solvent having a mixing ratio of ethanol and water of 1: 3 to 5, preferably 1: 3. At this time, the extraction temperature may be an extract extracted at 10 to 100 캜, preferably at room temperature, and for an extraction period of 12 to 4 days, preferably 24 hours.

The resultant filtered extract may be obtained by concentration under reduced pressure using a vacuum rotary condenser. However, the herbal extract having the inventive effect of inducing a sleep of the present invention is not limited to this, and the dried extract obtained by drying the extract, diluted solution, concentrate, , Or a controlled release or purified product thereof.

The composition for inducing sleep of the present invention may further comprise a second herbal medicine extract selected from the group consisting of licorice (Glycyrrhiza uralensis), Pterocarpus santalinus, Coptis japonica, and mixtures thereof in addition to the herbal extract .

That is, the herbal medicine extracts selected from the group consisting of Zizyphus jujuba, Poria cocos (Schw.), Cnidium officinale Makino, Polygala tenuifolia and mixtures thereof are added to Glycyrrhiza uralensis, Pterocarpus santalinus, Coptis japonica, and a mixture thereof may be further mixed to prepare a composition for inducing sleep.

The licorice (Glycyrrhiza uralensis) is a root and rootstock of soybean, European licorice, Manchuria licorice, and other herbaceous plants. It is collected in spring and autumn, and the beard roots are removed and sun dried. The nature is plain and the taste is sweet. It has the property of thawing when it is used, and it can treat Changyang, Tonghodok, Throat, and food poisoning. It also has the property of harmonizing the drug to attenuate the quasi-rugged nature of the drug. Abdominal pain, diarrhea, heart disease, heart palpitations, span, and lung can be treated.

The Pterocarpus santalinus is the main stem of the apical tree, and the red one is called the self-direction. The temperament is warm, and the [溫] taste is spicy. Toxic, poisonous, kwakran, sick under the mouth, mild, healed in vain. It is also known as a self diagnosis (紫 眞 檀).

The Coptis japonica is perennial, the rhizome is yellowish in color, grows laterally in the ground, and produces many beard roots. Leaf is long leaf, long petiole, 3 leaf is divided again, edge is pointed tooth shape. In early spring, flowers bloom about 10cm in length and bloom 2 ~ 3 white flowers with bags. Rhizomes are called antlers, and there is a branch, an antinociceptic action.

The composition for the induction of sleep comprising the natural herbal medicine component of the present invention is preferably selected from the group consisting of Zizyphus jujuba, Poria cocos (Schw.), Cnidium officinale Makino, Polygala tenuifolia, Glycyrrhiza uralensis , Pterocarpus santalinus, and Coptis japonica. That is, the herbal medicine extract may contain the herbal medicine extract as a main component.

More preferably, 60 to 100 parts by weight of licorice, 60 to 100 parts by weight of the licorice, 40 to 80 parts by weight of dicotyls, 20 to 60 parts by weight of the licorice, 10 to 30 parts by weight of the licorice, 30 parts by weight.

According to the above range, it is possible to provide a composition for oral hygiene or a composition for food which is highly efficient by enhancing the directionality of the mixed herbal medicine extract, exhibits a long-lasting sleep inducing effect, and has excellent palatability.

Herbal medicine extracts such as astragalus, daphnia, and oriental tendon which are included in the composition for inducing sleep may have poor taste in use when they are used in taste, spoilage compositions for oral hygiene or food compositions.

In order to prevent such a problem, the present invention can enhance the palatability and the sleep inducing effect when used as a composition for oral hygiene or a food composition by mixing natural extracts in addition to the herbal medicine extract.

The composition for inducing sleep of the present invention may preferably further comprise an extract of Yellow melilot, a extract of Pachysandra terminalis and a extract of Spiraea prunifolia for simpliciflora Nakai.

The above-mentioned Yellow melilot is also called a melon. It is the northern part of China. It grows in low-lying meadows. It is 60 to 90 cm high and branches are split and smelled when dried. There are hairs in my childhood, but they disappear later. Leaves are alternate phyllotaxis of three small leaves. Leaves are long oval or inverted, and have small sawtooth edges. The flower blooms in July or August and it is yellow, and it runs tightly with gunshot at the tip of the branch or the axilla. Calyx has hairy hairs. The fruit is egg-shaped, has no hair, and is black. The entire paste is used for heat, heat, nephritis, etc. It is called white algae (M. alba) that flowers are smaller and white. Everything that grows as a grass resource grows wild and grows.

The Pachysandra terminalis grows in the shade of the tree, with the main stem hanging sideways, the tip is straight, green, and initially there is hairy hair but gradually disappears. It grows up to about 30cm in height. Leaves are alternate but they are gathered in the upper part and look like inverted egg, with sawtooth on the upper part. Leaf hairs on leaf vein and narrowed lower part to become petiole. Flowers also bloom in April or May and are white and run on aquatic inflorescences. The female flower runs slightly under the flower head and the male flower runs on the upper part. Calyx is divided into 4 pieces and there are no petals. The stamen is divided into 3 to 5 and the style is divided into 2 pieces. The fruit is ovate, egg-shaped and has no hairs on the surface. It is distributed in Korea, Japan, Sakhalin Island, China.

The spore tree (Spiraea prunifolia for. Simpliciflora Nakai) is a deciduous shrub that grows in the sunshine at the base of the mountain. It is 1.5-2 m high. Its stem is brown, ridged and rusty. Leaves are alveolar, oval, and acuminate with small sawtooth on edge. Flowers are white and 4-5 flowers bloom on short branches in April-May. The fruit is cornelian and has no hairs, and ripens in September. The roots are taken from autumn to spring and dried in the sun.

When the natural extract is further contained, the bitter taste and pungent taste of the herbal extract can be neutralized and the flavor can be improved by mixing with other extracts, so that the composition can be provided as a composition for oral cleanser or a food composition having higher preference.

The natural extract is contained to neutralize the bitter taste and pungent taste of the herbal medicine extract, and a small amount thereof can be added to improve the flavor. More preferably, 60 to 100 parts by weight of licorice, 60 to 100 parts by weight of persimmon, 40 to 80 parts by weight of dicotyls, 20 to 60 parts by weight of persimmon, 10 to 30 parts by weight of persimmon, 10 to 30 parts by weight of an agar, 2 to 10 parts by weight of an electric sphagnum extract, 1 to 5 parts by weight of a succulent extract, and 1 to 5 parts by weight of a sphagnum extract.

As the natural extract is contained in a small amount as described above, it is possible to neutralize the bitter taste and spicy taste of the composition for inducing sleep induction, which is prepared by mixing herbal medicine extracts. When the amount is less than or more than the above range, there is a problem in that the degree of preference is lowered when the composition for inducing sleep is used as a composition for oral hygiene or a food composition.

The kind of the food of the present invention is not particularly limited. Examples of the health functional food to which the above extraction mixture can be added include meat products, sausages, breads, chocolates, candies, snacks, confectionery, pizza, ramen noodles, other noodles, gums, dairy products including ice cream, , A drink, an alcoholic beverage, and a vitamin complex, and may include foods used as food for animals, which may include all health functional foods in the conventional sense. In addition to the above, the health functional food composition of the present invention may contain various nutrients, vitamins, electrolytes, flavors, colorants, pectic acid and salts thereof, alginic acid and salts thereof, organic acids, protective colloid thickening agents, pH adjusting agents, stabilizers, , Alcohols, carbonating agents used in carbonated drinks, and the like. It may also contain flesh for the production of natural fruit juices, fruit juice drinks and vegetable drinks.

The dentifrice composition, mouthwash (goggle) and oral spray of the present invention can be used as a medicinal active ingredient as a dentifrice preventive agent such as sodium fluoride, sodium fluorophosphate, fluorinated amine, tin fluoride or xylitol; Chlorhexidine, cetylpyridinium chloride or triclosan, which are bactericides; Bamboo salt or propolis; Inflammatory emollients such as allantoin, aminocaproic acid, tranexamic acid, tocopherol acetate or methylsulfonylmethane; And one or more components selected from the group consisting of enzymes dextranase, glucose oxidase, glucoamylase,?,? -Amylase, lactoperoxidase and lysozyme.

In addition, the dentifrice composition, oral cleaning agent and oral spray of the present invention may further comprise at least one substance selected from the group consisting of abrasives, wetting agents, binders, foaming agents, sweeteners, anionic surfactants, perfumes and pigments. The form of the composition may be in the form of paste, powder, liquid (goggle type) or powder form.

According to the composition for inducing sleep of the present invention containing the natural herbal medicine component of the present invention, the aroma remaining in the oral cavity can be used to enhance the efficiency of inducing sleep and provide a long-lasting composition for inducing sleepiness.

In addition, when the composition for inducing sleep induction comprising the natural herbal medicine component is used, it can be provided as a dentifrice, a mouth spray, an oral cleanser or a chewing gum with high preference in use.

Hereinafter, embodiments of the present invention will be described in detail so that those skilled in the art can easily carry out the present invention. The present invention may, however, be embodied in many different forms and should not be construed as limited to the embodiments set forth herein.

[Preparation Example 1: Preparation of crude drug extract]

1. Manufacture of Sanjoin Extract (ZE)

The sanjoin was washed, dried and then ground. The pulverized material was mixed with purified water and maintained at 98-100 ° C for 2 hours. After cooling, it was filtered with Watman filter paper to obtain a filtrate.

2. Preparation of other herbal medicine extracts

(TE), licorice extract (GE), autoganous extract (SE) and extracts (JE) were prepared by the same method as that of the above acidogenic extract.

3. Preparation of composition for inducing sleep induction

The extracts of Zanthoxylin extract (ZE), dicotyl extract (PE), citron extract (CE), ground extract (TE), licorice extract (GE) To prepare a composition for water-surface induction.

MX1 MX2 MX3 MX4 MX5 MX6 MX7 MX8 MX9 MX10 ZE 100 100 100 100 100 100 100 100 100 100 PE 30 40 60 80 100 60 100 - 60 60 CE 10 20 40 60 80 40 80 40 - 40 TE 5 10 20 30 40 20 40 20 20 - GE 50 60 80 100 120 120 80 80 80 80 SE 50 60 80 100 120 120 80 80 80 80 JE 5 10 20 30 40 40 20 20 20 20

(Unit weight parts)

[Experimental Example 1: Experimental effect on the blood pressure and pulse rate of the composition for inducing sleep]

Blood pressure and pulse rate were measured with an aneroid blood pressure monitor in a sitting position after all subjects were stabilized for 10 minutes or more.

In order to test the effects of Experiment Numbers MX1 to MX10, blood pressure and pulse rate measurements were taken before and after taking 10 patients. The test subjects were 11 persons and 10 persons were diluted with water for the induction of MX1 to MX10 in the water to prepare oral hygiene agent and then gagged for 1 minute and 1 person was allowed to use garlic for 1 minute . Blood pressure and pulse rate were measured using an aneroid blood pressure monitor 10 minutes after the gaggle proceeded.

More specific results are shown in Table 2 below.

Gagle I After gaggle Blood pressure Pulse rate Blood pressure Pulse rate A (for drinking water) 124/80 82 120/78 80 B (using MX1) 110/61 57 116/65 54 C (using MX2) 128/75 80 120/77 75 D (using MX3) 135/79 80 123/73 70 E (using MX4) 138/80 92 126/78 85 F (using MX5) 145/84 88 141/83 84 G (using MX6) 138/80 88 130/76 84 H (using MX7) 128/80 76 120/80 78 I (using MX8) 136/76 78 135/79 75 J (using MX9) 120/80 80 124/75 78 K (using MX10) 140/82 88 142/84 88

According to the results in Table 2, it was confirmed that no significant difference was observed in blood pressure and pulse rate when boiled water was used.

On the other hand, when the experiment numbers MX1 to MX6 were used, the blood pressure and pulse rate decreased. This suggests that when the composition for sleep induction using MX1 to MX6 is used, a directional substance remains in the oral cavity and a directional substance directly reaches the olfactory epithelium to give a sense of stability, thereby reducing blood pressure and pulse rate .

In view of these results, it can be confirmed that the composition for sleep inducing MX1 to MX6 is used, and that the sleeping-inducing effect is excellent.

[Experimental Example 2: Experiment on effect of the composition for inducing sleep inducing on heart rate stability]

The same test group as that of Experimental Example 1 was measured using an autonomic nervous system diagnostic system (SA-3000NEW) after all the experimental groups were stabilized for 10 minutes or more.

The SDNN level was measured 10 minutes after the gaggle and after the gaggle. The SDNN value is a standard deviation of the total NN interval, which is a measure of how much the heart rate changes during recording time and reflects the stress resistance.

Generally, if you are over 50, you are in good health. If you are over 30, you should be over 21.

More specific results are shown in Table 3 below.

Gagle I After gaggle A (for drinking water) 52.024 51.879 B (using MX1) 59.615 60.950 C (using MX2) 49.145 49.816 D (using MX3) 50.217 54.003 E (using MX4) 25.075 26.384 F (using MX5) 44.107 45.681 G (using MX6) 38.178 39.021 H (using MX7) 43.289 43.277 I (using MX8) 50.169 50.171 J (using MX9) 49.856 49.857 K (using MX10) 53.246 53.244

Table 3 above shows SDNN values measured 10 minutes after the gag before and after the gag, and SDNN values were generally increased in the test group using the composition for the induction of MX 1 through MX 6 .

As described in Experimental Example 1, it is said that this is the result of the directional substance remaining in the oral cavity.

[Preparation Example 2: Preparation of herbal medicine extract having enhanced palatability]

1. Preparation of Electrophoresis (AE)

The motorized sieve was washed and dried and then pulverized. The pulverized material was mixed with purified water and maintained at 98-100 ° C for 2 hours. After cooling, it was filtered with Watman filter paper to obtain a filtrate.

2. Production of other natural extracts

(BE) and Zygomycorrhizae extract (DE) were prepared in the same manner as in the case of the electroresistant extract.

3. Preparation of compositions for improving sleepiness

The compositions for water-surface induction of MX3 prepared in Preparation Example 1 were prepared as shown in Table 4 below.

MX3 NX1 NX2 NX3 NX4 NX5 ZE 100 100 100 100 100 100 PE 60 60 60 60 60 60 CE 40 40 40 40 40 40 TE 20 20 20 20 20 20 GE 80 80 80 80 80 80 SE 80 80 80 80 80 80 JE 20 20 20 20 20 20 AE - One 2 6 10 15 BE - 0.5 One 3 5 10 DE - 0.5 One 3 5 10

(Unit weight parts)

 [Experimental Example 3: Sensory evaluation of composition for water-surface induction]

(Cline et al., 1992; Nurs Res, 41, 378-380) using a visual analogue scale (VAS) developed by Cline et al. In the test group, a total of 7 subjects were subjected to the psychological questionnaire after the composition of water, MX3, NX1 to NX5 was diluted with water for one week and used as an oral cleanser.

The scale used was the depression, anxiety, stress, fatigue, and emotions that the subject currently experiences on the 10-cm horizontal line, calculated from the most symptom-free from 0 to 100, in millimeters.

Gloom heaviness Anxiety headache flavor water 58 72 71 64 50 MX3 47 60 58 52 48 NX1 46 59 60 55 62 NX2 50 57 61 52 61 NX3 45 55 56 50 78 NX4 51 55 65 60 68 NX5 49 51 55 52 56

According to the above Table 5, it was confirmed that when the composition was mixed with the composition of MX3, it showed excellent values in depression, stiffness, anxiety and headache, compared with the case of using water. However, in the case of MX3, the palatability of the taste is poor.

Thus, it was confirmed that NX1 to NX5 exhibited equivalent or superior effects in depression, stiffness, anxiety and headache compared to MX3, and were superior in palatability of taste.

While the present invention has been particularly shown and described with reference to exemplary embodiments thereof, it is to be understood that the invention is not limited to the disclosed exemplary embodiments, Of the right.

Claims (10)

A perfume fragrance composition,
The one-way fragrance composition may be selected from the group consisting of Zizyphus jujuba extract, Poria cocos (Schw.) Extract, Cnidium officinale Makino extract, Polygala tenuifolia extract, Glycyrrhiza uralensis extract, Pterocarpus santalinus, Extract and Coptis japonica extract,
The composition further comprises a natural extract,
The natural extracts include Yellow melilot extract, Pachysandra terminalis extract and Spiraeaprunifolia for simpliciflora Nakai extract
A composition for oral cleaning comprising a natural herbal ingredient. The method according to claim 1,
The extract is extracted with a solvent selected from the group consisting of water, alcohols having 1 to 6 carbon atoms, and mixtures thereof
A composition for oral cleaning comprising a natural herbal ingredient. delete delete delete A composition for oral care comprising the composition according to claim 1
toothpaste. A composition for oral care comprising the composition according to claim 1
Oral Spray. A composition for oral care comprising the composition according to claim 1
Oral cleanser.
delete delete