CN107260792A - The composition of mouth disease is prevented or treated to being used for comprising natural complex - Google Patents

The composition of mouth disease is prevented or treated to being used for comprising natural complex Download PDF

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Publication number
CN107260792A
CN107260792A CN201710202985.XA CN201710202985A CN107260792A CN 107260792 A CN107260792 A CN 107260792A CN 201710202985 A CN201710202985 A CN 201710202985A CN 107260792 A CN107260792 A CN 107260792A
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composition
extract
mouth disease
treated
prevented
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CN107260792B (en
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刘锭宪
赵浩成
李相和
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LG H&H Co Ltd
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LG Household and Health Care Ltd
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Priority claimed from KR1020160041725A external-priority patent/KR101881636B1/en
Priority claimed from KR1020160076736A external-priority patent/KR102070316B1/en
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/533—Leonurus (motherwort)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/61—Myrtaceae (Myrtle family), e.g. teatree or eucalyptus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/86—Violaceae (Violet family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A61Q17/005—Antimicrobial preparations
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs

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  • Health & Medical Sciences (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
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  • Biotechnology (AREA)
  • Engineering & Computer Science (AREA)
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  • Mycology (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medical Informatics (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Dermatology (AREA)
  • Birds (AREA)
  • Cosmetics (AREA)
  • Medicines Containing Plant Substances (AREA)

Abstract

A kind of composition for preventing or treating mouth disease comprising natural complex of present invention offer, the composition for being used to preventing or treating mouth disease of the invention, it includes (i) Flos puerariae lobatae extract or (ii) Flos Caryophylli extract；And one or more of the group extract constituted selected from Flos puerariae lobatae extract, burdock extract, Herba Violae extract and Leonurus extract is as active ingredient, the mouth disease prevention of composition of the invention or therapeutic effect are excellent.In addition, the composition of the present invention is the material that natural products is originated, thus it is nontoxic, side effect is not also induced even if suitable for human body, therefore utilization rate is high.

Description

The composition of mouth disease is prevented or treated to being used for comprising natural complex
Technical field
The present invention relates to mouth disease prevention and/or therapeutic composition.
Background technology
As the theory of dental health is changed into social life theory, increase is focused on to oral health, not only counterpart Chamber prevention and treatment of diseases focuses on increase, and for carrying out the obstacle as important interpersonal relationships during social life The concern of halitosis is also in increase.
Dental tissue is made up of enamel, cementum and dentine.The outside for being exposed to the tooth of outside is covered by enamel, The outside of root of the tooth part in alveolar bone is covered by cementum, there is dentine inside it.In dentine, it is referred to as tooth The fine pipe of tubule is distributed in the range of whole dentine.
Carious tooth and periodontosis in mouth disease are used as induction pain, masticatory movement obstacle, the destruction of periodontium, halitosis And the various clinical symptom such as hemodia and cause the principal element of anodontia known, due to the change of dietetic life, The risk factor of carious tooth is continuing to increase.
As to perched in bacterial plaque and induce carious tooth, the Oral Pathogens of periodontosis, halitosis and hemodia are bred The method suppressed, a variety of antibiotic preparations comprising the antibiotic to these bacteriums with sterilization and bacteriostasis effect are developed to Carious tooth, periodontosis, suppression and the therapeutic agent of tooth marrow and apical infection.
But, antibiotic can induce the appearance of drug-fast bacteria in the side effect to the whole body of human body and oral cavity and repeat to feel Dye, therefore have the shortcomings that not being used for a long time and be used only as therapeutic agent.In addition, being used as the antibacterial used in mouth washes Preparation has sanguinarine (Sangquinarine), Li Shidelin (Listerine), peroxide (Peroxide), Chlorhexidine (Chlorhexidine) etc., but effect of the sanguinarine to bacterium in oral cavity is indefinite, when occurring periodontosis to therapeutic effect It is less well defined, and have the shortcomings that price is high, Li Shidelin is using ethanol as main component, and actual shown in oral cavity is faced When effect, with a little bacteriostasis, but when being used for a long time damaging effect showed to tissue, and be used for whitening effect recently Although and the peroxide added has toxic action to bacterium but while toxic action is still shown to tissue, not only There is problem in security, can also show the drug-fast bacteria to peroxide in bacterium sometimes.In addition, Chlorhexidine is used as tooth bacterium Spot formation suppresses and periodontosis prevention and treatment agent is that to be currently known preparation most excellent in preparation known, but exists pair The stimulation of tissue, the coloring of tissue and modification, especially show that excitant is strong, smell weight side effect, in addition may be used also Superinfection can be induced, with carcinogenicity, thus limited etc. for the use of pregnant woman, it is impossible to as treatment or especially to prevent mesh Long-term use.
Thus, the present inventor in order to export be not present side effect as described above and to mouth disease, i.e. toothache, carious tooth, Gingivitis, periodontitis, mucosal ulcer, halitosis, hemodia etc. have the natural of excellent prevention and/or therapeutic effect in oral cavity Material and studied.
Prior art literature
Patent document
Patent document 1：KR published patent the 10-2015-0050995th
Patent document 2：KR published patent the 10-2013-0105622nd
The content of the invention
Thus, it is an object of the present invention to provide this useful use of a kind of new active component, i.e. active component On the way, the problem of it can solve the problem that as described above, few side effects and safe to the human body, additionally it is possible to suppress the growth of oral cavity bacterium.
In other words, it is an object of the present invention to provide being used as active ingredient comprising the excellent active component of above-mentioned effect Composition.
It is an object of the invention to provide a kind of composition, it can be safe to use using safety in vivo it is natural come Derived components, treatment or improvement for mouth disease.
It is an object of the invention to provide a kind of composition for oral cavity, it utilizes natural material in the dental surface shape of damage Into film, hemodia symptom can be alleviated.
To realize the purpose, the composition for being used to preventing or treating mouth disease of the invention, it includes flower of kudzuvine extraction Thing is used as active ingredient.
To realize the purpose, the composition for being used to preventing or treating mouth disease of the invention, it includes flower of kudzuvine extraction Thing and Flos Caryophylli extract are used as active ingredient.
To realize the purpose, the composition for being used to preventing or treating mouth disease of the invention, it includes cloves extraction Thing and selected from Flos puerariae lobatae extract, burdock extract, Herba Violae extract and Leonurus extract constitute group in More than one extracts are used as active ingredient.
To realize the purpose, the present invention provides a kind of composition for oral cavity in natural materials source.Specifically, this hair Composition for oral cavity is provided in a bright embodiment, it is used as active ingredient comprising flower of kudzuvine (Pueraria).
That is, the present invention provides the composition for oral cavity for including flower of kudzuvine, is provided in particular in being used to preventing, improve or treating a variety of The new application of the composition for oral cavity of mouth disease.
In another embodiment, the present invention provides a kind of composition for being used to preventing and/or treating mouth disease, preferably A kind of composition for oral cavity, cosmetic composition, pharmaceutical composition or health-care food composition are provided, it is included：(i) flower of kudzuvine carries Take thing；Or
(ii) Flos Caryophylli extract；And it is female selected from Flos puerariae lobatae extract, burdock extract, Herba Violae extract and benefit One or more of the group that careless extract is constituted extract is used as active ingredient.
That is, the present invention provides a kind of new application for being used to preventing and/or treating mouth disease, and it is included：(i) flower of kudzuvine is extracted Thing；Or
(ii) Flos Caryophylli extract；And it is female selected from Flos puerariae lobatae extract, burdock extract, Herba Violae extract and benefit One or more of the group that careless extract is constituted extract.
Cloves (Syzygium aromaticum Merrill et Perry) refers to the sub- arbor cloves tree of tropical evergreen Bud part, Mo Lujiazhu islands are original producton location, originate in the Sang Jiba islands of Tanzania, Indonesian Sumatera, Brazil, Malaysia, Philippine, Vietnam, SOUTHERN CHINA etc..
Above-mentioned flower of kudzuvine refers to the bud or firm blooming flower of the root of kudzu vine (Pueraria lobata Ohwi), it is preferable that above-mentioned The bud of the root of kudzu vine after drying can be used in flower of kudzuvine.For each position of plant, its effect, effect are different, of the invention The root of flower of kudzuvine and the root of kudzu vine, the leaf of the root of kudzu vine are different without bitter taste, thus are adapted to be used in composition for oral cavity, by grinding for a long time The result studied carefully can confirm that out, compared with other positions of the root of kudzu vine, with excellent antibacterial activity and hemodia prevention and Improvement is remarkable.Especially, there is remarkable antibacterial effect to carious tooth pathogen.
Great burdock achene refers to the fruit of the great burdock achene (Arctium lappa Linne) as composite family (Compositae) plant It is real, also referred to as dislike real.
Chinese violet refers to the violet (Viola mandshurica W.Becker) or Chinese violet (Viola of Violaceae Yedoensis Makino) whole strain.Chinese violet has slightly special smell, with excitant, bitter, pungent, cool in nature.
Motherwort (Chinese motherwort) is by the motherwort (Leonurus of Labiatae (Labiatae) Sibiricus L) aerial part when the flowers are in blossom dries.Motherwort has slightly special smell, bitter, pungent, Bearberry Extract Property, slightly cool in nature.
The inventors discovered that, in use (i) Flos puerariae lobatae extract and (ii) Flos Caryophylli extract and selected from Flos puerariae lobatae extract, ox In the case of one or more of the group that burdock seed extract, Herba Violae extract and Leonurus extract are constituted extract, There is excellent effect to mouth disease, it is preferable that Flos Caryophylli extract, Flos puerariae lobatae extract, burdock extract, Chinese violet are extracted The mixed extract of thing and Leonurus extract has the biological activity of most excellent collaboration.
In the present invention, term " extract " includes handling by said extracted and extract solution, the said extracted liquid of acquisition Dilution or concentrate, the drying liquid that said extracted liquid is dried and obtained, the conditioning agent product of said extracted liquid or essence Refine the extract of thing or their mixture etc., extract solution itself and all formulations that can be formed using extract solution.
Said extracted thing in addition to specific position, can also include its leaf, stalk, tree when illustrating each plant Skin, root, flower or bud, fruit, seed, resin and whole plant.
In order to prepare said extracted thing, any appropriate method well known in the art can be used in those skilled in the art.Example Such as, it is possible to use gas phase extraction process or solvent extraction method.After plant entirety or arbitrary portion are crushed (for example, stirring), use Extraction solvent is handled, so as to obtain solvent extractable matter.Can also be before crushing, by drying process (for example, 40 Dried 15 to 50 hours to 70 DEG C) crushed afterwards.In addition, solvent extractable matter can pass through vacuum distillation and freeze-drying Or the additive proccess such as spray drying is prepared into pulverulence.
The species of Extraction solvent is not particularly limited used in above-mentioned, can be used as known in the art arbitrary molten Agent.Water can be used as the non-limiting example of said extracted solvent；The C1 such as methanol, ethanol, propyl alcohol, butanol to C4 are rudimentary Alcohol；The polyalcohols such as glycerine, butanediol, propane diols；And methyl acetate, ethyl acetate, acetone, benzene, hexane, diethyl ether, dichloro The hydrocarbon system solvents such as methane；Or their mixture, it is preferable that it can be used alone water, lower alcohol or by two or more mixing Use.It can be used more than above-mentioned solvent extraction once to prepare solvent extractable matter, can also prepare and subtract above-mentioned solvent extractable matter The dried extract for being freeze-dried after pressure distillation or being spray-dried and being obtained.
The amount of said extracted solvent can be different according to the species of used Extraction solvent, for example, can be planted relative to target The dry weight of thing uses 1 to 20 times, or 5 to 20 times.
Furthermore, it is possible to select using a variety of extraction processes well known in the art, for example impregnate (maceration), immersion (infusion), infiltration (percolation), digestion, decoction (decoction), high temperature continuously extract (hot continuous Extraction it is), aqueous-alcohol repellency extract, adverse current extraction, microwave radiation exaraction, ultrasonic wave extraction, supercritical fluid extraction, Tissue extracts (phytonic extract) (such as fluorinated hydrocarbon solvent)) etc., they can be performed separately or by two kinds Above method simultaneously is used for performing.
The composition of the present invention includes (i) Flos puerariae lobatae extract；Or (ii) Flos Caryophylli extract；And extracted selected from flower of kudzuvine One or more of the group that thing, burdock extract, Herba Violae extract and Leonurus extract are constituted extract conduct Active ingredient, preferably comprises Flos Caryophylli extract；And selected from Flos puerariae lobatae extract, burdock extract, Herba Violae extract with And one or more of the group extract that Leonurus extract is constituted is as active ingredient, more preferably comprising Flos Caryophylli extract, Pueraria lobota Flower extract, burdock extract, Herba Violae extract and Leonurus extract are used as active ingredient.
In the present invention, " comprising active ingredient is used as " refers to, can show outlet plenum disease using the composition of the present invention The degree of disease prevention and/or therapeutic effect adds extract, and he is to include to stabilize etc. and add Multiple components conduct Accessory ingredient simultaneously can be with variform formulation (formulation).
The composition of the present invention can include 0.0001 to 1 weight % active ingredient relative to composition total weight, preferably 0.0005 to 0.5 weight % can be included, 0.001 to 0.1 weight % can be more preferably included.
In the preferred embodiment of the present invention, comprising Flos Caryophylli extract, Flos puerariae lobatae extract, burdock extract, Herba Violae extract and Leonurus extract, can be by following ratio bags as in the composition of the invention of active ingredient Containing each plant extracts.For example, Flos Caryophylli extract：Flos puerariae lobatae extract：Burdock extract：Herba Violae extract：It is beneficial female The weight ratio of careless extract can include 1：0.1~10：0.1~10：0.1~10：0.1~10.
The composition of the present invention can be used to preventing, improve and/or treating mouth disease.
In the present invention, above-mentioned mouth disease is including but not limited to toothache, carious tooth, gingivitis, periodontitis, mucous membrane in oral cavity The concept of ulcer, halitosis, hemodia etc..
The composition of the present invention preferably can be used as gingivitis and/or periodontitis prevention, treatment and/or improve purposes.
Though for example, not limited to this, it may include the halitosis caused by the microorganism in oral cavity, mucous membrane is burst in carious tooth and oral cavity Ulcer etc..
In addition, above-mentioned mouth disease is in addition to the disease caused by microorganism in oral cavity, also it can include because of external physical Caused a variety of disease in mouth are stimulated, it is anti-to show allergy such as it can also include canaliculi dentales and expose because being worn away dental surface The hemodia symptom answered.
In the present invention, term " prevention " refers to all behaviors for suppressing or delaying disease using above-mentioned composition.
In addition, in the present invention, term " treatment " refers to make the institute of remission or the healing of disease using above-mentioned composition There is behavior.
In addition, term " improvement " as used in this specification refers to that hemodia symptom as described above is reduced or subtracted Weak, it is understood to include the wide concept of alleviation, prevention, treatment etc..
In the present invention, term " toothache " refers to the pain occurred on tooth, the pain occurred when generally representing to chew on tooth Bitterly.The reason for toothache, is not limited to this, including carious tooth, tooth marrow inflammation, impacted tooth, tooth folding, tooth wear disease etc..The present inventor confirms Going out the composition of the present invention has excellent inhibitory action to the PGE2 of the index as toothache.
In the present invention, term " carious tooth " refers to that tooth is damaged because of oral cavity bacterium, and thus produces carious tooth.For example, The bacterial plaque (plaque) that dental surface is generated as biomembrane can be one of reason.Above-mentioned oral cavity bacterium not limited to this, But can be streptococcus (Streptococcus) category, porphyromonas (Porphyromonas) category etc..
In the present invention, term " gingivitis " and " periodontitis " are bacterium, such as streptococcus being present in subgingival plaque (Streptococcus) bacterium such as category, porphyromonas (Porphyromonas) category is when forming suitable growth conditions, in tooth The soft tissue at gum position causes infection, develops into the periodontosis of gingivitis or periodontitis, so as to cause the oral cavity of the inflammation of gum Disease.Gingivitis, which deteriorates, becomes periodontitis.
In the present invention, term " halitosis " refers to that it is residual due to the protein in posteriori general disease or saliva, food The material that slag etc. is decomposed by the microorganisms and generated in oral cavity is decomposed, and thus generation induces the material of stench and occurs halitosis. As induce halitosis one-level reason oral cavity in microorganism do not limit, its can be streptococcus (Streptococcus) category, Porphyromonas (Porphyromonas) category, actinomyces (Actinomyces) category, Actinobacillus (Actinobacillus) category etc..
In the present invention, term " hemodia " not limited to this, but represent due to carious tooth or other causes for pathological and in addition Outside stimulus and show sensitivity pain temporarily or continuously all phenomenons.Said external, which is stimulated, generally represents temperature thorn Swash, symptom substantially is triggered to cool thermal stimulus, can also show pain at the temperature of heat sometimes.Except this thermal stimulus In addition, dry because of tooth, contact with exterior materials, pain also occurs in the stimulation such as osmotic pressure based on sweet tea or peppery food.Its Occur on all positions of whole tooth, can also be defined in the appearance of the privileged sites such as maxilla or lower jaw or right side or left side, also Can be with dentine hyperesthesia (dentine hyperesthesia), caries, tooth marrow inflammation.The present inventor confirms Go out, above-mentioned Flos puerariae lobatae extract can react with the calcium ion included in saliva and form film, the film of formation in dental surface Exposing for canaliculi dentales is blocked, so as to prevent, improve or treat hemodia symptom.
Term " mucosal ulcer in oral cavity " as used in this specification is also known as stomatitis (stomatitis), though do not limit In this, but it is also possible to including caused by oral cavity bacterium, virus, mould etc. infection and in oral cavity mucous membrane (tongue, gum, mouth Lip, on the inside of cheek etc.) produce the disease of inflammation.
Above-mentioned mouth disease, which has, to be induced by bacterium, and above-mentioned bacterium can be streptococcus (Streptococcus) category bacterium.
The composition of the present invention belongs to streptococcus (streptococcus) or porphyromonas (Porphyromonas) belongs to, more Specifically to selected from Streptococcus mutans (streptococcus mutans), Streptococcus sanguis (streptococcus Sanguis), blood red streptococcus (Streptococcus sanguinis), saliva chain coccus thermophilous subspecies (Streptococcus Salivarius subsp.thermophils) and porphyromonas gingivalis (Porphyromonasgingivalis) composition One or more of group bacterium there is remarkable antibacterial effect, thus confirm to have for prevention and treatment mouth disease excellent Different effect.
It is highly preferred that being gone out by experimental verification, composition of the invention is to Streptococcus mutans (streptococcus ) or porphyromonas gingivalis (Porphyromonasgingivalis) bacterium has remarkable antibacterial effect mutans.
The composition of the present invention can be composition for oral cavity.
Above-mentioned composition for oral cavity, according to its formulation and application target, generally may be used in addition to comprising above-mentioned active ingredient Further comprise as the wetting agent of composition, grinding agent, drug effect agent, sweetener, pH adjusting agent, preservative, binding agent, spices, foaming Agent etc..
As wetting agent, it is used alone or as a mixture selected from concentrated glycerin, glycerine, sorbitol aqueous solution, amorphism sorbierite Material in the group that the aqueous solution, polyethylene glycols and propane diols are constituted, its usage amount is relative to composition for oral cavity gross weight 1 to 70 weight % can be included.
As grinding agent, it can use selected from sedimentation silica, silica gel, zirconium silicate, calcium monohydrogen phosphate, anhydrous phosphoric acid hydrogen The group that calcium, aqueous alumina, precipitated calcium carbonate, powdered whiting, calcium pyrophosphate, insoluble metaphosphate and alumina silicate are constituted In one kind etc..The usage amount of such grinding agent, which is commonly angled relative to composition for oral cavity gross weight, can include 1 to 60 weight %. In addition, as the additive used on a small quantity, it can include and be used as the drug effect agent of usually used composition, sweetener, pH adjusting agent, anti- Rotten agent, colouring agent, foaming agent, binding agent etc., it can include 0.001 to 3 weight % relative to composition for oral cavity gross weight.
Drug effect agent can be by sodium fluoride, sodium monofluorophosphate, sodium fluoride, stannous fluoride, Chlorhexidine, allantoin chlorine hydroxy Al (allantoin chloro hydroxy aluminate), aminocaproic acid, zinc chloride, puridoxine hydrochloride, tocopherol acetate, enzyme Class etc. is mixed and used alone or in any combination.
As binding agent, sodium cellulose glycolate, carbomer, carragheen, xanthans, alginic acid salt etc. can be used, is made , can be by sodium alkyl sulfate, lauryl sodium sulfate, sucrose fatty ester, sorbitan fatty ester for foaming agent The anion and nonionic surfactant of (sorbitan monoester alkoxylate) etc. are mixed alone or in any combination And use.
As sweetener, saccharin, xylitol, antierythrite, Aspartame etc. can be used.
As pH adjusting agent, sodium phosphate, disodium hydrogen phosphate, citric acid, triethanolamine etc. can be used.
As preservative, benzoic acid, methyl p-hydroxybenzoate, propylparaben, sodium benzoate can be used Deng.As spices, peppermint oil, spearmint oil, menthol etc. can be mixed and used, as other additives, can also made With enzymes such as dextranases (dextranase).
As foaming agent, lauryl sodium sulfate as anionic surfactant can be used, as nonionic Property the copolymer (poloxamer) of polyethylene glycol oxide PPOX of surfactant, polyoxyethylene hydrogenated castor oil, poly- Ethylene oxide sorbitan fatty acid ester etc..
In addition, the water comprising surplus.
In addition, the present invention provides the product of oral cavity for including above-mentioned composition.
Include (i) Flos puerariae lobatae extract；Or
(ii) Flos Caryophylli extract；And it is female selected from Flos puerariae lobatae extract, burdock extract, Herba Violae extract and benefit One or more of the group that careless extract is constituted extract as active ingredient composition for oral cavity of the invention as The composition of oral hygiene, its can be all contained in prepared generally for oral health, commercially available product, to be applicable mouth Chamber is not limited with product (oral hygiene product).
For example, as above-mentioned product of oral cavity, including toothpaste, mouthspray liquid, mouthwass, oral cavity ointment, mouth Chamber paster, mouth washes, product of gargling, chewing gum etc., but not limited to this.The product of oral cavity of the present invention can be liquid State, solid-state, suspension, gel, aerosol form, but not limited to this.
The present invention oral hygiene composition be toothpaste type in the case of, except comprising Flos puerariae lobatae extract as effectively into Beyond point, grinding agent, binding agent, NMF, foaming agent, sweetener, whitening agent or flavouring agent can be additionally included.As above-mentioned Grinding agent, can individually or compound use aluminium hydroxide, silica, alumina silicate, Dicalcium Phosphate dihydroxide and acid anhydride, tricresyl phosphate Calcium, calcium carbonate, calcium pyrophosphate, insoluble sodium metaphosphate, tricresyl phosphate magnesium, magnesium carbonate, calcium sulfate, polymethyl methacrylate etc.. The content of above-mentioned grinding agent typically 20 weight % on the basis of total composition are not limited to above-mentioned contain to 90 weight % Amount.
In the case where above-mentioned oral hygiene composition is paste-like composition, above-mentioned binding agent can individually or compoundly make With carragheen, the gummy class of various thickenings cellulose derivative, xanthans, bassora gum (tragacanthgum) etc.；Polyethylene The organic system binding agents such as the synthesis polymeric derivative such as alcohol, Sodium Polyacrylate, polyacrylic acid/maleic acid, carbopol And inorganic system's binding agent such as silica, lithium magnesium silicate etc..The content of above-mentioned binding agent generally may be used on the basis of total composition 0.3 weight % is thought to 5 weight %, but is not limited to above-mentioned content.
In addition, above-mentioned oral hygiene composition is when it is prepared, can further comprise as the D-sorbite of NMF, glycerine, Ethylene glycol, propane diols, PPG, polypropylene glycol etc..
In addition, can be additionally comprising spices or sweetener etc. in above-mentioned oral hygiene composition.Above-mentioned sweetener can be Sucrose, lactose, maltose, D-sorbite, xylitol, sodium cyclohexylsulfamate, glycerine, saccharin sodium, stevioside, Aspartame Deng, above-mentioned spices can be peppermint, menthol, anethole, eugenol, limonene, citronellol, alpha-terpineol, gaultherolin, Cineole, linalool, ethyl linalool, vanillic aldehyde, thymol, spearmint oil, cyperus oil, rosemary oil, cassia oil etc., it is above-mentioned Sweetener or spices can individually or compoundly be used.
In addition, can be individually or compoundly comprising the surface used as foaming ingredient in the oral hygiene composition of the present invention Activating agent or additional functional component.The surfactant used as above-mentioned foaming ingredient can be selected from anion surface active Any of group that agent, nonionic surfactant and cationic surfactant are constituted.
In the case where the oral hygiene composition of the present invention is toothpaste, except including (i) Flos puerariae lobatae extract；Or
(ii) Flos Caryophylli extract；And it is female selected from Flos puerariae lobatae extract, burdock extract, Herba Violae extract and benefit Beyond one or more of the group that careless extract is constituted extract is as active ingredient, can by conventional toothpaste preparation method come Prepare, in the case where the oral hygiene composition of the present invention is mouthwash solution, flower of kudzuvine can be mixed in common pharmaceutical solutions Extract and formulation turn to mouthwash solution and prepared, and by one day to mouth washes 2 to 10 times, can prevent or treat mouth Chamber disease.
In addition, in the case where the oral hygiene composition of the present invention is toothpaste, can also include containing water and NMF Liquid, gelling agent or water-insoluble brightener, sweetener, spices etc..
In addition, in the case where the oral hygiene composition of the present invention is mouth washes (cleaning agent), can also include tooth Cream base, more specifically can additionally include non-toxic ethanol.
The method of the oral disease therapeutic or prevention composition that prepare the present invention can lead to according in this area for preparing it It is prepared by the method that often uses.
In addition, the composition of the present invention can be cosmetic composition.
The above-mentioned composition for being used to preventing and/or treating mouth disease is using selected from solution, externally-applied ointment, emulsifiable paste, bubble Foam, nutrition toner, soft toner, face cream, softened water, emulsion, foundation cream, Essence, soap, liquid ceanser, shower Dew, suncream, skin care oil, suspension, emulsion, paste, gel, lotion, powder, soap, the washing cream containing surfactant, It is prepared by formulation in the group that oil, powder cream base, emulsion foundation frost, wax powder cream base, patch and spray liquid are constituted, but Not limited to this.
In addition, the cosmetic composition of the present invention can be additionally comprising generally with the cosmeceutical being mixed in cosmetics for skin More than one admissible substrate, as common composition, for example, can suitably be compounded oil, water, surfactant, guarantor Humectant, lower alcohol, thickener, chelating agent, pigment, preservative, spices etc., but not limited to this.
The admissible substrate of cosmeceutical included in the cosmetic composition of the present invention is different according to formulation.In this hair In the case that bright formulation is ointment, paste, emulsifiable paste or gel, as substrate component, animality oil, vegetalitas can be used Oil, wax, paraffin, starch, tragacanth (Tragacant), cellulose derivative, polyethylene glycol, silicon, bentonite, silica, cunning Stone, zinc oxide or their mixture.
In the case where the formulation of the present invention is powder or spray liquid, as substrate component, can use lactose, talcum, Silica, aluminium hydroxide, calcium silicates, polyamide powder or their mixture, the situation particularly with spray liquid can be chased after also Plus ground includes the propellants such as chlorine fluorohydrocarbon, propane/butane or dimethyl ether.
In the case where the formulation of the present invention is solution or emulsion, as substrate component, solvent, solubilizer or emulsification are used Agent, for example, have water, ethanol, isopropanol, diethyl carbonate, ethyl acetate, Ergol, propane diols, 1,3- butyl glycols Oil, in particular cottonseed oil, peanut oil, corn semina oil, olive oil, castor oil and sesame oil, fatty acid glyceride, poly- second The fatty acid ester of glycol or anhydrosorbitol.
In the case where the formulation of the present invention is suspension, as substrate component, such as water, ethanol or the third two can be used Diluent, ethoxylated isostearyl alcohols, polyoxyethylene sorbitol ester and such as polyethylene glycol oxide dehydration mountain of the liquid of alcohol The suspending agent of pears sugar alcohol ester, fine crystal cellulose, inclined aluminium hydroxide (aluminum methahydroxide), bentonite, Agar or tragacanth etc..
In addition, the composition of the present invention can be pharmaceutical composition.
According to another embodiment of the present invention, the present invention, which is provided, contains (i) Flos puerariae lobatae extract；Or
(ii) Flos Caryophylli extract；And it is female selected from Flos puerariae lobatae extract, burdock extract, Herba Violae extract and benefit One or more of the group that careless extract is constituted extract as active ingredient the medicine for being used to preventing and/or treating mouth disease Compositions.
The present invention's includes (i) Flos puerariae lobatae extract；Or (ii) Flos Caryophylli extract；And selected from Flos puerariae lobatae extract, burdock The composition of one or more of the group that seed extract, Herba Violae extract and Leonurus extract are constituted extract can be with It is oral or para-oral a variety of formulations.Carry out it is formulation in the case of, using commonly used filler, swelling agent, It is prepared by the diluents such as binding agent, wetting agent, disintegrant, surfactant or excipient.Solid-state for oral administration Preparation includes tablet, pill, powder, granule, capsule etc., and such solid formulation is mixed in more than one compounds Come including at least more than one excipient, such as starch, calcium carbonate, sucrose (sucrose) or lactose (lactose), gelatin Prepared.In addition, except the simple excipient, also using the lubricant of magnesium stearate, talcum etc..As for passing through The liquid formulation of mouthful administration has suspending agent, interior use liquor, emulsion, syrup etc., except conventional water as simple diluent, Beyond atoleine, a variety of excipient can be also included, such as wetting agent, sweetener, aromatic, preservative.For non-oral The preparation of administration includes the aqueous solution, non-aqueous solvent, suspending agent, the emulsion of sterilizing., can as non-aqueous solvent, suspension agent With using plant oil such as propane diols (propyleneglycol), polyethylene glycol, olive oil, ethyl oleate can The ester of injection.
The present invention can also be provided for preventing and/or treating the formulation of the skin preparations for extenal use of mouth disease, and it is included Above-mentioned (i) Flos puerariae lobatae extract；Or
(ii) Flos Caryophylli extract；And it is female selected from Flos puerariae lobatae extract, burdock extract, Herba Violae extract and benefit One or more of the group that careless extract is constituted extract is used as active ingredient.
(i) Flos puerariae lobatae extract is being included by above-mentioned；Or (ii) Flos Caryophylli extract；And selected from Flos puerariae lobatae extract, burdock The composition conduct of one or more of the group that seed extract, Herba Violae extract and Leonurus extract are constituted extract In the case of skin preparations for extenal use use, can also additionally containing fatty material, organic solvent, lytic agent, concentrating agents and gelling agent, Softening agent, antioxidant, suspending agent, stabilizer, foaming agent (foaming agent), aromatic, surfactant, water, ionic Or nonionic emulsifier, filler, sequestering agent and chelating agent, preservative, vitamin, retarding agent, wetting agent, essence Oil, dyestuff, pigment, hydrophily or lipophile activating agent, lipid folliculus are typically used as the such as any of skin external preparation The commonly used preservative in Dermatology field of other compositions.In addition, mentioned component can be with Dermatology field In commonly used amount imported.
In above-mentioned (i) Flos puerariae lobatae extract；Or (ii) Flos Caryophylli extract；And extracted selected from Flos puerariae lobatae extract, great burdock achene One or more of the group that thing, Herba Violae extract and Leonurus extract are constituted extract is carried with skin preparations for extenal use formulation For in the case of, can have the formulation of such as ointment, patch, gel, emulsifiable paste or spray, but not limited to this.
The pharmaceutical composition of the present invention can be used as non-oral use preparation, and for example skin preparations for extenal use can be by by vaseline, hard The suitable preparation that lipidol etc. pharmaceutically allows；The suitable table that polysorbate, Sorbitan Sesquioleate etc. pharmaceutically allow Face activating agent；The suitable NMF that glycerine etc. pharmaceutically allows；The suitable solvent pharmaceutically allowed；And flavor component, It is prepared by the preparation method of the common skin preparations for extenal use that colouring agent, stabilizer, thickening agent etc. are equably mixed.
The pharmaceutical composition of the present invention is in above-mentioned (i) Flos puerariae lobatae extract comprising effective dose；Or (ii) Flos Caryophylli extract； And one in the group constituted selected from Flos puerariae lobatae extract, burdock extract, Herba Violae extract and Leonurus extract In the case of the extract for planting the above, using the teaching of the invention it is possible to provide preferred mouth disease prevention and/or therapeutic effect.In the present invention, " effectively Amount " is the amount for referring to fully show mouth disease prevention and/or therapeutic effect.
Above-mentioned (i) Flos puerariae lobatae extract included in the composition of the present invention；Or (ii) Flos Caryophylli extract；And be selected from One or more of group that Flos puerariae lobatae extract, burdock extract, Herba Violae extract and Leonurus extract are constituted carries The effective dose of thing is taken to be applied to the method for skin by the form of commercialization, above-claimed cpd according to composition and be trapped in skin On time etc. and it is different.For example, in the case where above-mentioned composition is made into medicine, with being normally manufactured as being applied to skin The situation of the cosmetics of skin is compared, and above-mentioned (i) Flos puerariae lobatae extract can be included in the way of high concentration；Or (ii) cloves is extracted Thing；And in the group constituted selected from Flos puerariae lobatae extract, burdock extract, Herba Violae extract and Leonurus extract More than one extracts.
According to another embodiment of the present invention there is provided a kind of health food for being used to preventing and/or treating mouth disease, its Include above-mentioned (i) Flos puerariae lobatae extract；Or (ii) Flos Caryophylli extract；And selected from Flos puerariae lobatae extract, burdock extract, pale reddish brown One or more of the group that Chinese violet extract and Leonurus extract are constituted extract is used as active ingredient.
" health food " refers in this specification, includes (i) Flos puerariae lobatae extract；Or
(ii) Flos Caryophylli extract；And it is female selected from Flos puerariae lobatae extract, burdock extract, Herba Violae extract and benefit It is fragrant that one or more of the group that careless extract is constituted extract is added to beverage, teas, spice, mouth as active ingredient In the food materials such as sugar, Dessert, or as the food for being prepared into encapsulated, powdered, suspension etc., when being absorbed pair Health care belt carrys out specific effect, but from unlike typical medicine, it is using food as raw material, in the absence of having in prolonged administration of drugs Shi Fasheng side effect etc..The health food of the invention so obtained is realized to oral cavity due to that can be absorbed daily The excellent effect of disease, thus be highly useful.
By above-mentioned (i) Flos puerariae lobatae extract；Or (ii) Flos Caryophylli extract；And carried selected from Flos puerariae lobatae extract, great burdock achene One or more of the group of thing, Herba Violae extract and Leonurus extract composition extract is taken to be used as active ingredient , can be by above-mentioned (i) Flos puerariae lobatae extract in the case of making food additives；Or (ii) Flos Caryophylli extract；And carried selected from flower of kudzuvine One or more of the group of thing, burdock extract, Herba Violae extract and Leonurus extract composition extract is taken to make Directly add, or be used together with other food or food composition for active ingredient, can be suitably used according to conventional methods. The combined amount of active ingredient can suitably be determined according to its application target (prevention, healthy or therapeutic disposal).Generally, in food During the preparation of product or beverage, composition of the invention is added below 15 parts by weight, below preferably 10 parts by weight relative to raw material Amount.But, for the taken long-term for the purpose of health and health or for the purpose of health regulation in the case of, above-mentioned amount can be with It is that below above range, due to any problem being not present in terms of security, active ingredient can also be used more than above range Amount.Species to above-mentioned food is not particularly limited.There are meat, perfume (or spice) as the example for the food that can add above-mentioned substance Intestines, bread, chocolate, confectionery, snack class, Dessert, Piza, hand-pulled noodles, other noodles, gummy class including ice cream exist Interior dairy products, various soup, beverage, tea, decoction agent, alcohol drink and compound vitamin etc., it may include on ordinary meaning All health foods.The healthy beverage composition of the present invention such as common beverage, can contain multiple scents or natural carbon Hydrate etc. is used as additional composition.Above-mentioned natural carbohydrate is monose such as glucose, fructose；Such as malt Sugar, the disaccharides of sucrose and such as polysaccharide of dextrin, cyclodextrin；The sugar alcohols such as xylitol, sorbierite, antierythrite.It is used as sweet taste Agent, can use such as natural sweetener of Talin, stevia extract or such as synthetic sweetener of saccharin, Aspartame Deng.The ratio of above-mentioned natural carbohydrate is typically about 0.01~0.04g relative to every composition 100mL of the invention, excellent Elect about 0.02~0.03g as.Than that described above, health food of the invention can containing a variety of nutritional agents, vitamin, electrolyte, Flavor enhancement, colouring agent, pectic acid and its salt, alginic acid and its salt, organic acid, protectiveness gum thickener, pH adjusting agent, stably Carbonating agent used in agent, preservative, glycerine, ethanol, soda etc..In addition, the health food of the present invention can contain useful In the pulp of the preparation of fruit juice, fruit drink and vegetable beverage.Such composition individually or mixing and use.This It is 0.01~0.1 parts by weight generally in every parts by weight of composition 100 of the invention though the ratio of the additive of sample is less important In the range of select.
The present invention's includes (i) Flos puerariae lobatae extract；Or (ii) Flos Caryophylli extract；And selected from Flos puerariae lobatae extract, burdock One or more of the group that seed extract, Herba Violae extract and Leonurus extract are constituted extract is used as active ingredient Composition mouth disease prevention or therapeutic effect it is excellent.
In addition, the composition of the present invention is the material that natural products is originated, thus it is nontoxic, also do not lured even if suitable for human body Side effect is sent out, therefore utilization rate is high.
Brief description of the drawings
Fig. 1 is to confirm the pain of each extract and (each to plant as the chart of the PGE2 of Inflammation Marker suppression effect " extract " is deleted in thing extract and botanical name is only shown).
Embodiment
Below, to help to understand the present invention, enumerate embodiment etc. and be described in detail.But according to the implementation of the present invention Example can be deformed into a variety of other forms, should not be construed as the scope of the present invention and be limited to lower embodiment.Embodiments of the invention are used for Those skilled in the art are more completely illustrated and provided.
Material prepares
The preparation of Flos Caryophylli extract
Gas phase extracting is carried out to cloves and cloves gas phase extract is obtained.
The preparation of Flos puerariae lobatae extract
Flower of kudzuvine is frittered, is impregnated in 95% ethanol solution, is extracted 48 hours at normal temperatures and the extraction of flower of kudzuvine ethanol is obtained Thing.
The preparation of burdock extract
Great burdock achene is frittered, is impregnated in 95% ethanol solution, extracts 48 hours at normal temperatures and obtains great burdock achene ethanol Extract.
The preparation of Herba Violae extract
The whole strain of Chinese violet is frittered, is impregnated in 95% ethanol solution, extracts 48 hours at normal temperatures and obtains pale reddish brown Chinese violet ethanol extract.
The preparation of Leonurus extract
Motherwort is frittered, is impregnated in 95% ethanol solution, extracts 48 hours at normal temperatures and obtains motherwort ethanol Extract.
Cloves, flower of kudzuvine, great burdock achene, Chinese violet, the preparation of motherwort (five kinds) mixed extract
By it is above-mentioned respectively with extract form prepare cloves, flower of kudzuvine, great burdock achene, Chinese violet, Leonurus extract with 1：1：1：1：1 ratio is injected and prepares cloves, flower of kudzuvine, great burdock achene, Chinese violet, motherwort mixed extract.
The preparation of embodiment and comparative example
The component of the present inventor's table 1 below is prepared for confirming for the embodiment of the effect of mouth disease and right with it The comparative example toothpaste answered.I.e., first of all for preparing toothpaste, it is (dense using sodium cellulose glycolate, lauryl sodium sulfate, glycerine Glycerine (98%)), sorbitol aqueous solution (70%), silica-based (sedimentation silica), xanthans, sodium fluoride, spices, sugar Essence, citric acid etc. prepare comparative example toothpaste, are prepared for the embodiment toothpaste of the mixed extract herein containing 0.01 weight %.
Table 1
Composition name (unit：Weight %) Embodiment 1 Embodiment 2 Comparative example
Settle silica 20.0 20.0 20.0
Concentrated glycerin (98%) 30.0 30.0 30.0
Sorbitol aqueous solution (70%) 30.0 30.0 30.0
Lauryl sodium sulfate 1.0 1.0 1.0
Sodium cellulose glycolate 0.5 0.5 0.5
Xanthans 0.5 0.5 0.5
Sodium fluoride 0.22 0.22 0.22
Spices 1.0 1.0 1.0
Saccharin 1.0 1.0 1.0
Citric acid, triethanolamine (TEA) In right amount In right amount In right amount
Mixed extract 0.01 - -
Flos puerariae lobatae extract - 0.01 -
Purified water To 100 To 100 To 100
The ＞ of ＜ experimental examples 1
Antibacterial effect confirms
The present inventor is come to confirm the excellent antibacterial effect of mixed extract using paper dish (paper disk) determination method Implement antibacterial activity test, judge to use the gram-positive bacteria Streptococcus mutans that Induction of bacterial is represented as carious tooth and periodontosis And as gram-negative bacteria porphyromonas gingivalis whether have suppress bacterial strain effect.Above-mentioned each bacterium is in table 2 below Optimal culture condition under cultivate activity after, in the optimal medium of each bacterium cultivate 4~6 hours or so, adjust nutrient solution Turbidity become Macfarland turbidity No.0.5 (1.5 × 108) after, equably smear 0.1ml.In sterilizing Paper dish (Whatman no.5paper, 8mm diameter) in, every (table 3) extract is connect with 10mg/disc concentration Kind, absorb and used after drying 1 hour.After being cultivated 24~48 hours in the optimum temperature of above-mentioned each bacterium, growth is determined low The size (diameter mm) of alicyclic ring.
Table 2
Its result is illustrated in table 3 below (omission shows " extract " in each plant extracts in lower item).
Table 3
As a result, can confirm that out in above-mentioned table 3, cloves, flower of kudzuvine, Chinese violet, great burdock achene and Leonurus extract In, the growth low fat ring of Flos puerariae lobatae extract is revealed as most wide.
It can confirm that out in addition, compared with each extract, the growth in the mixed extract comprising Flos Caryophylli extract is low Alicyclic ring diameter is revealed as excellent effect, includes the whole life of cloves, flower of kudzuvine, Chinese violet, great burdock achene and Leonurus extract Long low fat ring diameter is most wide for Streptococcus mutans and porphyromonas gingivalis.
The ＞ of ＜ experimental examples 2
PGE2 inhibitions confirm
The present inventor is in order to confirm the toothache remission effect of mixed extract, it is thus identified that be used as pain and Inflammation Marker PGE2 suppression effect.With 1.5 × 10 in the DMEM culture mediums of the macrophage comprising 10%FBS5Cells/ml concentration is entered Row inoculation, with 37 DEG C, 5%CO2Condition was in 24 orifice plate culture 24 hours.Then, inflammation is induced stimulates reason creotoxin (LPS) 1 μ g/ml and each extract are handled, and PGE2 inhibitory action is have rated with the culture upper liquid of 24 hours.Its result is shown For Fig. 1.
As a result, as can confirm that out in above-mentioned Fig. 1, compared with each extract, the mixing comprising Flos Caryophylli extract is carried Thing is taken to show excellent effect comprising the whole effect of cloves, flower of kudzuvine, Chinese violet, great burdock achene and Leonurus extract Fruit is the most excellent.
The ＞ of ＜ experimental examples 3
Gingivitis formation inhibition confirms
The present inventor has used the embodiment and comparative example tooth of above-mentioned table 1 to confirm gingivitis formation inhibition Cream.Experimental subjects is so that denture is neat, tooth N/D gingivitis patient as object, according to the age from 30 years old to 50 years old, with It is within 10 years old interval, according to sex, accurate dental examination is implemented to every 30, selects after 120 experimental subjects groups, be divided into each 60, perform the clinical trial to gingivitis therapeutic effect.
It is experimental group (embodiment) and control group (comparative example) by experimental subjects component, after the meal after 2 hours, makes it Used 3 times daily before sleep, implement scaling, fractionation is carried out to initial gingivitis indices, it is used each toothpaste group Compound, after by 1 week, 1 month, 3 months and 6 months, implements dental examination, and check gingivitis indices.Gingivitis The assay method of index is to insert periodontal probe (periodontal probe) in gingival sulcus, with the state of not applying power, combustion Burn around each tooth, carry out probe, after by 30 seconds, determine the state of bleeding, the standard recording fraction shown in table 4 below And obtain result.
The results are shown in table 5.
Table 4
Fraction Content
0 point Without bleeding state
1 point Normal bleeding state
2 points Streak-like hemorrhage state
3 points Triangle bleeding state in position between tooth
4 points Gum entirety bleeding state
Table 5
Period Control group Experimental group
0 week 1.05 1.05
1 week 1.51 1.05
1 month 2.64 1.08
3 months 2.79 1.08
6 months 2.83 1.09
As a result, can confirm that out from shown in above-mentioned table 5, in the case of using the experimental group of embodiment toothpaste for, It has passed through after 6 months, gingivitis indices almost do not rise with preliminary phase than also, for the feelings of the control group using comparative example toothpaste For condition, starting after 1 week, gingivitis indices sharp rise, formed so as to can not suppress gingivitis.
Thus, confirming the composition of the present invention has excellent gingivitis formation inhibition.
The ＞ of ＜ experimental examples 4
Hemodia inhibition confirms
The present inventor has used the embodiment and comparative example toothpaste of above-mentioned table 1 to confirm hemodia inhibition.Will With hyperesthesia tooth and agree to participate in the volunteer 40 of this experiment as research object, ultimate survey target tooth is 80 .In addition, male is 20 in volunteer, women is 20, and the age was from 20 years old to 50 years old.Research object is set to be unaware of in toothpaste Tolerant, total experimental period is set to two weeks.(experimental group 1：Embodiment, experimental group 2：Embodiment 2, control group：Comparative example).
Experiment is implemented using the method for measure reaction after thermal stimulus is applied.Before experiment is implemented, in advance The allergy position of the hyperesthesia tooth of each volunteer is first checked, about 5 DEG C cool is added dropwise at the allergy position of tooth with minim pipette Water, after being scored, makes it, daily using 3 each compositions, after two weeks, minim pipette be used again during two weeks About 5 DEG C of cold water is added dropwise to be scored.Post-stimulatory reaction standards of grading setting is as follows.(0 point：Without any discomfort Sense, 1 point：Slightly feel uncomfortable or cool, 3 points：Pain).As statistical disposition, the stimulation fraction profit before implementation and after two weeks will be tested Verified with paired student-t test.
The fraction reacted to thermal stimulus after two weeks is illustrated in table 6 below.
Table 6
Period Control group Experimental group 1 Experimental group 2
0 week 2.14±0.14 2.13±0.20 2.14±0.06
Two weeks 2.15±0.21 1.72±0.09 1.55±0.28
P ＞ 0.05 * p ＜ 0.05 * p ＜ 0.05
As a result, can confirm that out from shown in above-mentioned table 6, initial stage control group and experimental group in the reaction on thermal stimulus Larger difference is not present on fraction, but after two weeks, does not show difference in control group, and in the case of experimental group, instead Fraction is answered meaningfully to reduce.
That is, confirm that excellent hemodia suppresses to imitate using the embodiment toothpaste of the mixed extract comprising the present invention Really.In the case of the independent treatment group of flower of kudzuvine, it can be identified that going out with excellent hemodia inhibition.
The ＞ of ＜ experimental examples 5
Halitosis removal effect confirms
The present inventor has used the embodiment and comparative example toothpaste of above-mentioned table 1 to confirm halitosis removal effect.
50 men and women of no carious tooth disease are selected, intersection is implemented to target beverage and tests (Cross-over repeatedly test).Commercially available garlic powder is dispersed in water, after placing 24 hours, is diluted, makes halimeter (Halimeter) Measured value turns into more than 700ppb, and above-mentioned dilution then is used as into halitosis induces source.Gargle 30 with garlic powder dilution 15ml Second, with after halimeter measure halitosis degree after 1 minute, use experimental group and control group (experimental group 1：Embodiment, experiment Group 2：Embodiment 2, control group：Comparative example) toothpaste carry out gargle within 30 seconds~1 minute.After gargling, by 1 minute, 5 minutes, After 30 minutes, halitosis degree is determined with halimeter to determine halitosis suppresses whether to continue.
Its result is illustrated in table 7 below.
Table 7
Period Control group Experimental group Experimental group 2
1 minute 55.8% 96.9% 96.8%
5 minutes 45.1% 87.2% 87.9%
30 minutes 37.2% 85.6% 82.4%
As a result, can confirm that out from shown in above-mentioned table 7, the experimental group of embodiment toothpaste has been used compared to having used ratio Control group compared with example toothpaste shows excellent halitosis inhibition.In the case of the independent treatment group of flower of kudzuvine, it can be identified that Go out with excellent halitosis inhibition.

Claims (13)

1. a kind of composition for being used to preventing or treating mouth disease, it is used as active ingredient comprising Flos puerariae lobatae extract.
2. a kind of be used to preventing or treating the composition of mouth disease, it is comprising Flos puerariae lobatae extract and Flos Caryophylli extract as having Imitate composition.
3. a kind of be used to preventing or treating the composition of mouth disease, its comprising Flos Caryophylli extract and selected from Flos puerariae lobatae extract, One or more of the group that burdock extract, Herba Violae extract and Leonurus extract are constituted extract is as effective Composition.
4. the composition of mouth disease is prevented or treated to being used for according to any one of claim 1 to claim 3, its In, the mouth disease is mucosal ulcer, halitosis and hemodia in toothache, carious tooth, gingivitis, periodontitis, oral cavity One or more of group of composition disease.
5. the composition of mouth disease is prevented or treated to being used for according to any one of claim 1 to claim 3, its In, the mouth disease is gingivitis or periodontitis.
6. the composition of mouth disease is prevented or treated to being used for according to any one of claim 1 to claim 3, its In, the active ingredient includes 0.0001 weight % to 10 weight % relative to the composition total weight.
7. the composition of mouth disease is prevented or treated to being used for according to any one of claim 1 to claim 3, its In, the active ingredient includes 0.001 weight % to 1 weight % relative to the composition total weight.
8. the composition of mouth disease is prevented or treated to being used for according to any one of claim 1 to claim 3, its In, the composition has antibacterial effect to streptococcus or porphyromonas accessory.
9. the composition according to claim 8 for being used to preventing or treating mouth disease, wherein, the streptococcus is change Different streptococcus.
10. the composition according to claim 8 for being used to preventing or treating mouth disease, wherein, the porphyromonas category For porphyromonas gingivalis.
11. the composition of mouth disease is prevented or treated to being used for according to any one of claim 1 to claim 3, Wherein, the composition is used as composition for oral cavity, cosmetic composition, pharmaceutical composition or health-care food composition.
12. the composition of mouth disease is prevented or treated to being used for according to any one of claim 1 to claim 3, Wherein, the extract is to utilize to be selected from water, distilled water, methanol, ethanol, propyl alcohol, isopropanol, butanol, acetone, ether, benzene, chlorine In the group that imitative, ethyl acetate, dichloromethane, n-hexane, hydrochloric acid, acetic acid, formic acid, diethyl ether and hexamethylene are constituted it is a kind of with Upper solvent extraction.
13. the composition according to claim 11 for being used to preventing or treating mouth disease, wherein, the oral composition Thing has to be constituted selected from toothpaste, mouthwass, oral cavity spray liquid, oral cavity ointment, oral cavity paster and chewing gum One or more of group formulation.
CN201710202985.XA 2016-04-05 2017-03-30 Composition for preventing or treating oral diseases comprising natural complex Active CN107260792B (en)

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CN108403514A (en) * 2018-05-02 2018-08-17 山东胜伟旅游发展有限公司 The preparation method of toothpaste containing salt-soda soil burdock extract
CN113491641A (en) * 2020-03-19 2021-10-12 株式会社Lg生活健康 Composition containing pueraria flower glucoside

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