KR101981253B1 - Manufacturing method of mackerel concentrate pill for constipation - Google Patents

Abstract

The present invention relates to a method of manufacturing a constipation-improving circle using an extract of mackerel, and more particularly, to a method of manufacturing a constipation-improving circle using a mackerel extract, which comprises a concentrated liquid extracted from mackerel, .
A method for manufacturing a constipation-improving circle using a mackerel extract according to the present invention comprises a first step of preparing a mixture by mixing mackerel and distilled water; A second step of heating the mixture to produce a first mackerel extract; A third step of adding a second mackerel extract to the first mackerel extract by adding onion, green tea, perilla, ginger, jujube, parsley, garlic, bamboo, citrus peel, sorghum and licorice; A fourth step of concentrating the second mackerel extract to produce a mackerel concentrate; A fifth step of preparing a concentrated mackerel powder by pulverizing the mackerel concentrate; A sixth step of mixing and kneading the mackerel concentrated powder with a ground stone powder, a brown sugar powder, a brown rice powder, a barley powder and a glutinous rice powder; And a seventh step of shaping the dough into a ring shape and drying the kneaded product.

Description

{Manufacturing method of mackerel concentrate pill for constipation using mackerel extract}

The present invention relates to a method of manufacturing a constipation-improving circle using an extract of mackerel, and more particularly, to a method of manufacturing a constipation-improving circle using a mackerel extract, which comprises a concentrated liquid extracted from mackerel, .

Constipation is known to be the origin of the stomach from ancient times, and it is absorbed in the blood by absorbing the toxin of the non-excreted side into the intestine, thereby promoting skin aging, headache, acne and skin rash. In severe cases, And it is reported to be related to the risk of colon cancer and rectal cancer.

As a cause of constipation, intake of high-calorie foods such as meat and instant foods containing high-fat high-protein foods is becoming a cause of various metabolic syndromes such as obesity, hyperlipidemia, constipation and the like, as compared with food intake which is relatively fibrous.

In recent years, the skinny body has become a health and high position, preferring a slim figure regardless of sex, both young and old, and preferring a low calorie diet.

In addition, due to the busy modern life, irregular eating habits are increasing the reliance on drugs, and drugs can be accompanied by side effects such as abdominal distension, diarrhea, and furrowing.

According to the results of the National Health Insurance Corporation 's Big Health Data Analysis, patients treated with constipation increased by 11.3% in 2015 compared to 2010 and showed an increasing tendency in various classes. Regular diet with good quality food is very important for constipation treatment and dietary fiber intake is necessary.

Mackerel, a typical red fish caught in the coast of Korea, is a physiologically superior food because it contains not only n-3 and n-6 polyunsaturated fatty acids but also high quality amino acids and nucleic acids. It is also known that the content of DHA among hyperunsaturated fatty acids, which are excellent in anticancer and anti-inflammatory action, cholesterol lowering action, antihypertensive action, antimicrobial, detoxifying action, immune strengthening function and prevention of adult diseases, is higher than that of saury or mackerel .

 In Korea, studies on the storage and quality of mackerel, the antioxidation and inhibition of cancer cell proliferation by dried mackerel extract, and the separation and purification of mackerel-derived antihypertensive Peptided There have been no studies on constipation using mackerel.

Korean Patent No. 10-1104070

Disclosure of Invention Technical Problem [8] Accordingly, the present invention has been made to solve the above-mentioned problems, and it is an object of the present invention to provide a method of manufacturing a constipation-improving poultry using a mackerel extract, which is processed so that a mackerel extract, which is effective for improving constipation, have.

It is to be understood that both the foregoing general description and the following detailed description are exemplary and explanatory and are not restrictive of the invention as set forth in the accompanying drawings. It will be possible.

A method for manufacturing a constipation-improving circle using a mackerel extract according to the present invention comprises a first step of preparing a mixture by mixing mackerel and distilled water; A second step of heating the mixture to produce a first mackerel extract; A third step of adding a second mackerel extract to the first mackerel extract by adding onion, green tea, perilla, ginger, jujube, parsley, garlic, bamboo, citrus peel, sorghum and licorice; A fourth step of concentrating the second mackerel extract to produce a mackerel concentrate; A fifth step of preparing a concentrated mackerel powder by pulverizing the mackerel concentrate; A sixth step of mixing and kneading the mackerel concentrated powder with a ground stone powder, a brown sugar powder, a brown rice powder, a barley powder and a glutinous rice powder; And a seventh step of shaping the dough into a ring shape and drying the kneaded product.

According to the solution of the above-mentioned problem, the method of manufacturing constipation-improving circulation using the mackerel extract of the present invention has an effect of increasing the possibility of consumption of mackerel extract by providing a mackerel extract having an excellent effect for improving constipation more easily.

FIG. 1 is a flow chart showing a flow of a constipation improvement ring manufacturing method using a mackerel extract according to the present invention.

The above and other objects, features and advantages of the present invention will be more apparent from the following detailed description taken in conjunction with the accompanying drawings, in which: FIG. BRIEF DESCRIPTION OF THE DRAWINGS The advantages and features of the present invention and the manner of achieving them will become apparent by reference to an embodiment which will be described in detail below with reference to the accompanying drawings.

Hereinafter, a constipation improvement ring manufacturing method using the above-described mackerel extract will be described in detail with reference to the drawings.

≪ Method for producing constipation-improving pills using mackerel extract >

FIG. 1 is a flow chart showing a flow of a constipation improvement ring manufacturing method using a mackerel extract according to the present invention.

First, a mixture is prepared in a first step (S10). Specifically, the mackerel after removing the viscera and the tail is mixed with distilled water to prepare a mixture.

The mixing ratio of the mackerel and distilled water is preferably 0.2 to 0.3 parts by weight of distilled water per 1 part by weight of mackerel. When 1 part by weight of the mackerel is mixed with less than 0.2 part by weight of distilled water, the solvent may become insufficient during heating to increase the viscosity, so that extraction may be difficult. When the amount is more than 0.3 part by weight, Can occur.

Next, in the second step S20, the first mackerel extract is prepared. Specifically, the mixture is inserted into a hot water tank or an extractor, and heated to prepare a first mackerel extract.

The heating of the first mackerel extract is preferably performed at 110 ° C for 10 hours. If the heating temperature is lower than 110 ° C, the extraction time may be excessively long. If the heating temperature is higher than 110 ° C, the active ingredient may be destroyed. If the heating time is less than 10 hours, the effective ingredient may not be sufficiently extracted. If the heating time exceeds 10 hours, the extraction is completed and the efficiency of the work is lowered.

Next, in the third step (S30), the second mackerel extract is prepared. Specifically, the first mackerel extract solution is prepared by adding a first ingredient mixed with onion, green tea, perilla, ginger, jujube, pungsten, garlic, bamboo, citrus paprika, sorghum and licorice to the first mackerel extract.

Next, in a fourth step (S40), a mackerel concentrate is prepared. Specifically, the mackerel concentrate is prepared by heating the second mackerel extract.

The heating of the mackerel concentrate is preferably performed at 110 ° C for 12 hours. If the heating temperature is lower than 110 ° C, the extraction time may be excessively long. If the heating temperature is higher than 110 ° C, the active ingredient may be destroyed. If the heating time is less than 12 hours, the effective ingredient of the first sub ingredient may not be sufficiently extracted. If the heating time exceeds 12 hours, the concentration is already completed and the efficiency of the work is lowered.

The sugar content of the mackerel concentrate is preferably 15 to 30 brix. When the sugar content is less than 15 brix, the concentration is insufficient and the content of the active ingredient may be lowered. When the sugar content exceeds 30 brix, the concentration time becomes excessively long.

Next, in a fifth step (S50), concentrated mackerel powder is prepared. Specifically, the mackerel concentrate is pulverized using a spray dryer.

The spray dryer (spray dryer) is a drying apparatus capable of instantly making a raw liquid into particles. The drying liquid is atomized by a nozzle or a disk in a drying chamber to increase the surface area near the unit volume, And the particles are instantaneously dried and assembled.

Even though the spray dryer is a heat sensitive material, it is extremely denatured, and many other processes such as concentration, filtration, pulverization, classification, and drying can be performed once, and other operations can be omitted. It is excellent, easy to dissolve in water for use in foods and pharmaceuticals.

Next, in a sixth step (S60), the mackerel concentrated powder is kneaded. Concretely, the mackerel concentrated powder is mixed with a ground stone powder, a ground powder, a brown rice powder, a barley powder and a glutinous rice powder as a second material, and then a solvent is added to the mixture.

The ground stone powder, the brown sugar powder, the brown rice powder, the barley powder, and the glutinous rice powder are prepared by drying the foundation stone, brown rice, brown rice, barley and glutinous rice at 50 ° C for 48 hours and removing the foreign matter.

If the drying temperature is less than 50 캜, the drying time may be excessively long. If the drying temperature is more than 50 캜, the active ingredient in the material may be destroyed or altered. If the drying temperature is less than 48 hours, the drying may not proceed sufficiently and there may be a risk of deterioration of the raw materials. If the drying temperature exceeds 48 hours, the drying may be completed and the efficiency of the work may be lowered.

The dough is performed by adding a solvent, and it is generally preferable that the solvent is distilled water.

When the amount of the solvent is less than 0.1 part by weight based on 1 part by weight of the whole powder, it is difficult to produce a ring shape due to a low degree of aggregation. When the amount of the solvent is more than 0.2 parts by weight, the drying time may be prolonged. Failure may occur.

Next, in a seventh step (S70), the dough is used to manufacture a ring. Specifically, the dough is formed into a ring shape and then dried.

In order to demonstrate the effect of improving the constipation of the mackerel concentrate used in the method of manufacturing constipation-improving circulation using the extract of mackerel in the present invention, experiments are conducted and details of the experiment are described in detail below.

1. Devices used in the experiment

: Biochemical analysis equipment (Roche Ltd, Basel, Switzerland), Dry oven (Wiseven, WOF-50) and High centrifuge (Hanil HMR-1610V, Korea) were used.

2. Mackerel concentrate

: The mackerel concentrate used in the experiment is the mackerel concentrate prepared on the basis of the method of manufacturing constipation-improving circles using the mackerel extract of the present invention.

3. Experimental animals

: The ICR mouse used for this study and the 7-week-old model (male) were sold from Sam Taco Bio Korea (Seongnam, Korea, Gyeonggi Province) and quarantined for one week at the Animal Husbandry Institute (26.11 ℃), humidity (50.12%) and lighting time were set to 12 hours (07: 00 ~ 19: 00).

As shown in Table 1, the fecal weight and the moisture content were measured by measuring the fecal weight and the moisture content in a total of 5 groups of 16 rats per each group.

 In each group, 200 mg / kg of the mackerel concentrate (including the first sub ingredient) (SA group), mackerel concentrate (not including the first sub ingredient) of the present invention (group N) kg body weight (group SB), and the positive control group was orally administered for 6 days in a group of 120 mg / kg (group P), an individual approved product for health food, by the improvement of constipation. (1% tween80 / saline) was orally administered to each group (groups C, P, SA, and SB). The diets were fed with 25 g of daily intake of solid feed (Samtaco BIOKOREA, Korea) and 100 ml of negative water. The body weight change was measured once every two days. The animals were fasted for 16 hours before the dissection and the animals were treated for a certain period of time (10: 00-12: 00 am). This study was conducted in accordance with the policies and regulations of SEMI (Institutional Animal Care and Use Committee). (Ethics approval number: SEMI-17-04)

(Experimental chajeonjapi (psyllium husk) used as a positive control at the sides gives help to increase the excretion volume to absorb water in the colon as a destination sikyak Performance Materials, is receiving attention as a low-calorie food materials, energy reduced calorie food)

Group Design Number One N D.W.p.o 1% Tween 80 / saline, p.o 16 2 C
Loperamide
5 mg / kg, po
16 3 P Sole - Charcoal 100% p.o 16 4 SA * Mackerel concentrate p.o 16 5 SB * Mackerel concentrate p.o 16

A. Fecal change Measurement of moisture content (after induction of constipation)

 The feces of each experimental animal were collected daily for 5 days after the start of the experiment, and the weight and number of feces per 1 cage were measured. Moisture content was determined by oral administration of loperamide 5 mg / kg 1 hour after the administration of each sample, followed by induction of constipation and fecal sampling for 8 hours. The feces were then weighed at 105 ° C dry oven for 48 hours. Water content changes were calculated as follows.

Change in moisture content (%) = (Change in weight before drying - Change in weight after drying for 48 hours) / (Change in weight before drying) * 100

Table 2 shows the results of examining the effect of the mackerel extract and mackerel product on the moisture content of the feces.

Group Wet fecal
(Before-After) Dry fecal
(Before-After) Water Content N 0.55 + 0.66 0.41 + - 0.01 24.53 + - 6.53 C 0.48 + 0.13 0.41 + 0.09 12.29 + - 3.71 P 0.96 + 0.04 0.66 + - 0.05 31.07 ± 7.64 SA 1.13 + 0.03 0.75 + - 0.05 33.27 ± 2.49 SB 1.20 ± 0.17 0.76 + 0.09 36.60 ± 1.69

 Compared with group C, SA and SB (33.27%, 36.60%) showed about three times higher water content than group C (12.29%) treated with Loperamide alone. Therefore, it can be confirmed that the mackerel concentrate of the present invention enhances the water content of the feces through the above-mentioned experiment results, and thus it helps to improve the constipation.

S10. Preparation of mixture
S20. Manufacture of 1st mackerel extract
S30. Manufacture of second mackerel extract
S40. Manufacture of mackerel concentrate
S50. Manufacture of concentrated mackerel powder
S60. dough
S70. Ring molding

Claims (5)

A first step of mixing 0.2 to 0.3 parts by weight of distilled water with respect to 1 part by weight of mackerel to prepare a mixture;
A second step of preparing the first mackerel extract by heating the mixture at 110 DEG C for 10 hours;
A third step of adding a second mackerel extract to the first mackerel extract by adding onion, green tea, perilla, ginger, jujube, parsley, garlic, bamboo, citrus peel, sorghum and licorice;
A fourth step of concentrating the second extract of mackerel through heating at 110 DEG C for 12 hours to prepare a mackerel concentrate;
A fifth step of preparing a concentrated mackerel powder by pulverizing the mackerel concentrate;
Mixing the ground mackerel powder, the brown rice powder, the brown rice powder, the barley powder, and the glutinous rice powder into the concentrated mackerel powder and kneading the mixture with distilled water;
And a seventh step of shaping the dough into a ring shape and drying the dough,
When the mackerel concentrate is prepared in the fourth step, the sugar content is 15 to 20 brix,
Wherein the crude stone powder, the brown rice powder, the brown rice powder, the barley powder and the glutinous rice powder are dried by subjecting each of the ground stone, brown rice, brown rice, barley and glutinous rice to drying at 50 ° C for 48 hours, Method for making constipation improvement pills delete delete delete delete

Images