KR101973807B1 - A composition for preventing hair loss or promoting hair growth comprising a natural extract - Google Patents

Abstract

The present invention relates to a composition for preventing hair loss or hair growth comprising a natural extract, and more particularly, to a composition for promoting hair loss prevention or hair growth, which comprises extracting a mixture of papaya, ginseng, Hassuo, Angelica gigas, Hanshikoshi, The present invention relates to a composition for preventing hair loss or promoting hair growth comprising an extract prepared by extracting an extract or a mixture of papaya, ginseng, dashi, angelica, gossam, celeste,
The present invention can provide a composition for preventing hair loss or for promoting hair growth, which can be easily and simply produced and can alleviate the progress of hair loss and promote hair growth.
In addition, the present invention can minimize the side effects of accelerating the production of scalp or sebum, and can provide a hair loss-preventing or hair growth promoting composition capable of sustained hair growth promotion.

Description

[0001] The present invention relates to a composition for preventing hair loss or promoting hair growth comprising a natural extract,

The present invention relates to a composition for preventing hair loss or hair growth comprising a natural extract, and more particularly, to a composition for promoting hair loss prevention or hair growth, which comprises extracting a mixture of papaya, ginseng, Hassuo, Angelica gigas, Hanshikoshi, Extracts produced; The present invention also relates to a composition for preventing hair loss or promoting hair growth comprising an extract prepared by extracting a mixture of papaya, ginseng, hansoo, angelica, gossam, celestial goby, alfalfa, alfalfa, licorice, mushroom,

Hair loss is known to be caused by unbalanced diet, excessive drinking and smoking, drug abuse, sleep deprivation, stress, childbirth, menopausal disorders, frequent perms and dyes, and hormone imbalance.

As a result of these various causes, the number of hair loss increases as the hair of the crown and forehead becomes thinner and weaker, and when this phenomenon continues, hair loss becomes worse enough to be observed directly with the naked eye.

Korean Patent Laid-Open No. 10-2006-0010035 discloses a composition containing 10 to 40% by weight of an extract of herbal medicines, 0.1 to 15% by weight of a viscosity control agent, 30 to 30% by weight of a surfactant 30 By weight to 80% by weight, and 0.1 to 15% by weight of an oil, based on the total weight of the composition.

Korean Patent Laid-Open No. 10-2007-0052046 discloses a powder or a piece of ginseng having a length of 2 to 5 mm with 20 to 30% by weight of ginseng, 20 to 30% by weight of bagasse, 20 to 30% A first step of processing and mixing; (2) a step (2) of adding the raw materials to be processed and mixed in the step (1) into water having a dry weight ratio (l / kg) of 4 to 8 times and stirring at 60 to 100 ° C for 2 to 10 hours to obtain an extract; A third step of performing centrifugal dehydration or filter pressing in order to remove the solid content remaining in the extract liquid of the second step; In order to remove insoluble microparticles and proteins in the extract of step 3, an enzymatic reaction such as protease, peptase, and lipase is induced at 30 to 60 ° C, the enzyme activity is removed at a high temperature of 90 ° C or higher, And then obtaining a colored transparent extract using an ultra-high speed centrifuge at 15,000 to 20,000 rpm; Passing through an activated carbon filter to remove the fat component, the phenolic compound, and the tannin component in the extract obtained in the step 4; 6) removing the inactive polymer carbohydrate and the microorganisms using the micro filtration system or the ultrafiltration system; And 7) step of desalting and concentrating the extract of step 6 by reverse osmosis membrane several times, freezing it at -40 ° C with a freeze-drying device, and then drying the mixture at elevated temperature. Discloses a hair growth promoting composition for dietary administration.

Korean Patent Registration No. 10-0846572 discloses a pharmaceutical composition for preventing hair loss and promoting hair growth, which comprises an extract of Canavalia gladiata as an active ingredient and a pharmaceutically acceptable carrier.

The methods of treating hair loss include topical application agents, oral preparations, health supplements, gene transplantation, and hair transplantation. However, these methods are limited in scope and do not prevent hair loss.

The effects of medication are also temporary and there is a side effect that rather accelerates the production of scalp or sebum.

In order to solve the above-mentioned problems, it is necessary to develop new hair-producing products, thick hair, and a hair-care product having a normal hair cycle.

Korean Patent Publication No. 10-2006-0010035 Korean Patent Publication No. 10-2007-0052046 Korean Patent No. 10-0846572

Disclosure of Invention Technical Problem [8] Accordingly, the present invention has been made to solve the above problems occurring in the prior art, and it is an object of the present invention to provide a composition for preventing hair loss or promoting hair growth, which can be easily and simply produced and can alleviate the progress of hair loss and promote hair growth.

Another object of the present invention is to provide a composition for preventing hair loss or promoting hair growth, which can minimize the adverse effects of accelerating the production of scalp or sebum and can promote hair growth.

In order to achieve the above object, the present invention provides an extract for hair loss prevention or hair growth stimulation, which is prepared by extracting a mixture of papaya leaf, ginseng, Hassuo, Angelica gigas, Hanshiku, black bean, Seokchangpo, gingerol, shiitake mushroom, .

The present invention also provides an extract for hair loss prevention or hair growth, which is prepared by extracting a mixture of papaya, ginseng, hassuo, angelica, gossam, celestium,

In one embodiment of the present invention, the extract is prepared by extracting the mixture with ethanol, filtering, concentrating under reduced pressure, and then freeze-drying the concentrate.

In an embodiment of the present invention, the mixture comprises 5 to 20% by weight of a lateral leaf, 5 to 20% by weight of ginseng, 5 to 20% by weight of dassia, 5 to 20% , 1 to 10 wt% of mushrooms, 1 to 10 wt% of mushrooms, and 5 to 20 wt% of rice bran, 5 to 20 wt% of rice bran, 5 to 20 wt% of rice bran, 1 to 10 wt% of shiitake mushroom,

In one embodiment of the present invention, the mixture comprises 5 to 20% by weight of the leaves, 5 to 20% by weight of ginseng, 5 to 20% by weight of dessicant, 5 to 20% 1 to 10% by weight of mushroom gum, and 1 to 10% by weight of ginger is contained in an amount of 5 to 20% by weight, an essential oil of 5 to 20% by weight, an essential oil of 5 to 20% .

The present invention also provides a pharmaceutical composition for preventing hair loss or promoting hair growth comprising the extract as an active ingredient.

The present invention provides a food composition for preventing hair loss or promoting hair growth comprising the extract as an active ingredient.

The present invention provides a cosmetic composition for promoting hair loss prevention or hair growth comprising the extract as an active ingredient.

The present invention can provide a composition for preventing hair loss or for promoting hair growth, which can be easily and simply produced and can alleviate the progress of hair loss and promote hair growth.

In addition, the present invention can minimize the side effects of accelerating the production of scalp or sebum, and can provide a hair loss-preventing or hair growth promoting composition capable of sustained hair growth promotion.

Figure 1 shows the hair growth effect when the extract is treated with a mouse. (a) dietary intake group, (b) dietary intake and application group
Figure 2 shows photographs of the hair growth effect when the extract was treated with a mouse (diet-fed group).
Fig. 3 shows photographs of the hair growth effect when the extract was treated with a mouse (dietary intake and application group).
Figure 4 shows plasma GOT and GPT when treated with extracts from mice. (a) Dietary intake GOT, (b) Dietary intake GPT
Figure 5 shows plasma GOT and GPT when the extract is treated with the mouse. (a) Dietary intake and application group GOT, (b) Dietary intake and application group GPT

Hereinafter, the present invention will be described in detail based on examples. It is to be understood that the terminology, examples and the like used in the present invention are merely illustrative of the present invention in order to more clearly explain the present invention and to facilitate understanding of the ordinary artisan, and should not be construed as being limited thereto.

Technical terms and scientific terms used in the present invention mean what the person skilled in the art would normally understand unless otherwise defined.

The present invention relates to an extract (extract B) for preventing hair loss or promoting hair growth, which is prepared by extracting a mixture of papaya, ginseng, Hassuo, Angelica gigas, Hanshiku, black soybean, Seokchangpo,

The present invention also relates to an extract (extract H) for preventing hair loss or promoting hair growth, which is prepared by extracting a mixture of papaya, ginseng, Hassuo, Angelica gigas, Gossam, Tangshan,

The extract is prepared by extracting the mixture with ethanol, filtering, concentrating under reduced pressure, and lyophilizing the concentrate.

The extraction may be performed by adding 500 to 3,000 parts by weight of ethanol to 100 parts by weight of the mixture, heating the mixture at 25 to 90 ° C for 10 to 200 hours, and repeating the extraction for 1 to 10 times with ethanol for 10 to 20 hours.

After extraction, the mixture is filtered through a filtration membrane having a pore diameter of 0.2 to 1 탆. The filtrate is concentrated under reduced pressure using a vacuum concentrator to remove all of the solvent. The filtrate is stored in an ultra-low temperature freezer (-70 ° C) and freeze-dried to obtain an extract.

5 to 20 wt% of ginseng, 5 to 20 wt% of ginseng, 5 to 20 wt% of ginseng, 5 to 20 wt% of Angelica keiskei, 5 to 20 wt% of Hansikucho, 5 to 20 wt% 5 to 20% by weight of gingerol, 1 to 10% by weight of shiitake mushroom, 1 to 10% by weight ginseng root and 1 to 10% by weight of ginger.

5 to 20 wt% of ginseng, 5 to 20 wt% of ginseng, 5 to 20 wt% of ginseng, 5 to 20 wt% of ginseng, 5 to 20 wt% of ginseng, 5 to 20 wt% of ginseng, 5 to 20 wt% 5 to 20% by weight of Rhizoctonia sp., 5 to 20% by weight of licorice, 1 to 10% by weight of Shiitake mushroom, 1 to 10% by weight of ginseng root, and 1 to 10% by weight of Gugija.

When the content of the components constituting the mixture satisfies the above-described numerical value range, the effect of preventing hair loss and promoting hair growth can be maximized.

The extract contains polyphenol and flavonoid, and contains 755.0 mg / g or more of polyphenol and 42.4 mg / g or more of flavonoid based on 1 g of the extract.

In addition, the DPPH IC50 of the extract (the concentration required to inhibit the DPPH radical by 50%) shows a value of 3.1 to 3.4 mg.

For example, the extract B contains 755.0 mg / g of polyphenol and 42.4 mg / g of flavonoid, and the DPPH IC50 has a value of 3.1 mg.

The extract H contained 1,394.3 mg / g of polyphenol and 78.1 mg / g of flavonoid, and the DPPH IC50 value was 3.4 mg.

The present invention also relates to a pharmaceutical composition for preventing hair loss or promoting hair growth comprising the extract as an active ingredient.

The pharmaceutical compositions of the present invention may further comprise suitable carriers, excipients and diluents conventionally used in the manufacture of pharmaceutical compositions.

The carriers, excipients and diluents include lactose, textol, sucrose, sorbitol, mannitol, xylitol, erythritol, maltitol, starch, acacia rubber, alginate, gelatin, calcium phosphate, calcium silicate, cellulose, methylcellulose, Polyvinylpyrrolidone, water, methylhydroxybenzoate, propylhydroxybenzoate, talc, magnesium stearate, and mineral oil.

The pharmaceutical composition of the present invention can be formulated in the form of powders, granules, tablets, capsules, suspensions, emulsions, oral formulations such as syrups and aerosols, external preparations, suppositories and sterilized injection solutions.

The pharmaceutical compositions of the present invention may be administered to mammals, such as humans, by a variety of routes, for example, by oral, intravenous, intramuscular or subcutaneous injection.

The pharmaceutical compositions of the present invention may be administered or applied locally. Topical application or topical application means direct application of the composition to the skin or hair.

The topical compositions of the present invention may be in the form of solutions, lozenges, pads, creams, ointments, liposomes, sprays, gels, foams, roller sticks or any other formulations routinely used in dermatology .

The composition of the present invention can be used for the prevention, treatment or improvement of alopecia. Alopecia Areata, Androgenetic Alopecia, Telogen Effluvium, Traumatic alopecia, Trichotillomania ), Pressure alopecia, alopecia alopecia, alopecia alopecia, Alopecia syphlltiac, Alopecia seborrhecia, symptomatic alopecia, cicatric alopecia, congenital alopecia.

The present invention relates to a food composition for preventing hair loss or promoting hair growth comprising the extract as an active ingredient.

The food may be in the form of various foods, candy, beverage, gum, tea, vitamin complex, health functional food, etc., and may be provided in the form of powder, granule, tablet, capsule, drink or the like.

The present invention relates to a cosmetic composition for preventing hair loss or promoting hair growth comprising the extract as an active ingredient.

The cosmetic composition may be manufactured in various forms according to a conventional cosmetic preparation method.

For example, the cosmetic composition may be manufactured in the form of a perfume product containing the extract, a shampoo, a hair lotion, a hair cream, a hair gel, a hair tonic, a shampoo, a rinse, a soap, a lotion, an essence, It can be diluted with a cleansing liquid, a converging liquid and a moisturizing liquid.

The cosmetic composition may also contain customary adjuvants or cosmetically acceptable carriers such as stabilizers, solubilizers, vitamins, pigments and fragrances which are commonly used in the cosmetic composition field.

Examples of the carrier which is acceptable for cosmetics include purified water, oil, wax, fatty acid, fatty acid alcohol, fatty acid ester, surfactant, hygroscopic agent, thickener, viscosity stabilizer, chelating agent, buffer, preservative, lower alcohol and the like .

If necessary, a moisturizing agent, an anti-inflammatory agent, an antibacterial agent, an antifungal agent, a vitamin, a sunscreen agent, an antibiotic, a perfume, a dye and the like may be used.

Hereinafter, the present invention will be described in detail with reference to examples. The following examples are intended to illustrate the practice of the present invention and are not intended to limit the scope of the present invention.

(Example 1) Preparation of extract B

2,700 g of ethanol was added to 270 g of a mixture of 30 g of Ganoderma lucidum, 30 g of Ganoderma lucidum, 30 g of Ganoderma lucidum, 30 g of Ganoderma lucidum, 30 g of Hansikucho, 30 g of black soybean, 30 g of Seokchangpo, 30 g of Gigobarin, 10 g of Shiitake mushroom, 10 g of Ganoderma lucidum and 10 g of Gugija . After extraction, it was filtered with ADVANTEC NO.2 paper filter and concentrated under reduced pressure using a vacuum concentrator to remove all the solvent.

The concentrate was stored in an ultra-low temperature freezer at -70 DEG C and then lyophilized to obtain an extract.

(Example 2) Preparation of extract H

3,300 g of ethanol was added to 300 g of a mixture of 30 g of Ganoderma lucidum, 30 g of Ganoderma lucidum, 30 g of Ganoderma lucidum, 30 g of Ganoderma lucidum, 30 g of Ganoderma lucidum, 30 g of Ganoderma lucidum, 30 g of Ganoderma lucidum, 30 g of Sesame bran, 30 g of licorice, 30 g of Licorice, 10 g of Shiitake mushroom, Respectively.

After extraction, it was filtered with ADVANTEC NO.2 paper filter and concentrated under reduced pressure using a vacuum concentrator to remove all the solvent.

The concentrate was stored in an ultra-low temperature freezer at -70 DEG C and then lyophilized to obtain an extract.

(Example 3) Dietary intake group setting

To investigate the effects of dietary intake, animal experimental groups were set up as shown in Table 1.

Three weeks old C57BL / 6 mice were fed free diet for 5 weeks.

Group IS-1 ID-1 ISE-1 IDE-1 ISB-1 IDB-1 ISH-1 IDH-1 Fe + - + - + - + - Vitamin E - - + + + + + + extract B B H H

(Example 4) Dietary intake and application group setting

In order to investigate the effect of application of food at the same time, animal experiment group was set up as shown in Table 2.

Three - week - old C57BL / 6 mice were fed free diet for 5 weeks. When the extract was applied, the extract was applied at 6 and 7 weeks of age.

Minoxil 3% coating agent was used as a comparative group to compare the coating effect of the extract of the present invention.

Group IS-2 ID-2 ISE-2 IDE-2 ISB-2 IDB-2 ISH-2 IDH-2 ISM-2 IDM-2 Dietary intake Fe + - + - + - + - + - Vitamin E - - + + + + + + + + extract B B H H apply Extract +
Lotion B B H H Minoxil 3% + +

(Example 5) Hairy effect when the extract was treated with mouse

The hair growth effect in the case of ingesting a diet containing 0.1% of the extract is shown in FIG. 1 (a). The hair growth effect in the case of eating a diet containing 0.1% of the extract and applying a coating agent containing 3% Is shown in Fig. 1 (b).

In FIG. 1, the y axis represents the percentage (%) occupied by the area of the hair growth area in the hair removal area.

The ISB-1 group, which consumed the iron-rich diet and extract B, and the IDH-1 group, which consumed the iron-deficient diet and the extract H, had a higher hair growth promoting effect than the control group when the diet containing 0.1% of the extract was consumed (Fig. 1 (a)).

The seedling yield of the IDH-2 group treated with the iron-deficient dietary supplement and the extract H and the extract H at the same time, when the dietary supplement containing 0.1% of the extract and the coating agent containing 3% of the extract were applied, 78.5%, which was significantly higher than the control group (Fig. 1 (b)).

The IDH-2 group had a 15% higher rate of growth than the IDH-1 group, which consumed iron-deficient diets and extracts.

In the IDH-2 group, the hair growth rate was 92.8% of the IDM-2 group in which Minoxil 3% was applied, indicating that the hair growth promoting effect was high.

Therefore, the IDH-2 group that consumed the iron deficiency diet and the extract H and the extract H applied the extract showed the best growth rate. Therefore, when the extract of the present invention is ingested and applied to the scalp, .

The hair growth effect after 2 weeks of hair removal, when the extract was treated with the mouse, is shown in Figs.

(Example 6) When the extract was treated with mouse, plasma GOT and GPT

The body weight and liver weight of the experimental group consumed or applied the extract were not significantly different from those of the control group, and the hemoglobin concentration in the blood was not significantly different between the experimental group and the control group.

However, plasma ferritin level was higher than that of iron deficient diets.

Plasma GOT and GPT in the experimental group consuming Extract B or Extract H were somewhat higher in the iron-rich diet group (Figs. 4 and 5).

The plasma GOT of the IDH-2 group containing the iron-deficient diet and the extract H and the extract H applied at the same time as the food containing the 0.1% extract and the coating agent containing 3% GPT was similar to the control group.

In addition, plasma GOT and GPT of the IDH-2 group are similar to those of the plasma GOT and GPT of the IDM-2 group coated with Minoxil 3%.

Claims (8)

A composition for preventing hair loss or promoting hair growth comprising an extract prepared by extracting a mixture of Korean white ginseng, Korean ginseng, Hassuo, Angelica gigas, Hansuccho, Black bean, Seokchangpo, Gigobin, Shiitake mushroom,
The extract is prepared by extracting the mixture with ethanol, filtering, concentrating under reduced pressure and freeze-drying the concentrate,
5 to 20 wt% of ginseng, 5 to 20 wt% of ginseng, 5 to 20 wt% of ginseng, 5 to 20 wt% of Angelica keiskei, 5 to 20 wt% of Hansikucho, 5 to 20 wt% Wherein the composition comprises 5 to 20% by weight of gingerol, 1 to 10% by weight of shiitake, 1 to 10% by weight of ginseng root, and 1 to 10% by weight of ginger.
1. A composition for promoting hair loss or preventing hair loss comprising an extract prepared by extracting a mixture of Korean Leaves, Ginseng, Hassuo, Angelica ginseng, Radix Herba, Rootstock, Lycopersicon esculenta, Lycopersicon esculenta, Lycopersicon esculentum,
The extract is prepared by extracting the mixture with ethanol, filtering, concentrating under reduced pressure and freeze-drying the concentrate,
5 to 20 wt% of ginseng, 5 to 20 wt% of ginseng, 5 to 20 wt% of ginseng, 5 to 20 wt% of ginseng, 5 to 20 wt% of ginseng, 5 to 20 wt% of ginseng, 5 to 20 wt% Characterized in that the composition comprises 5 to 20% by weight of Rhizobium ores, 5 to 20% by weight of licorice, 1 to 10% by weight of shiitake mushroom, 1 to 10% by weight of marshmallow, and 1 to 10% Composition.
delete delete delete delete 3. The method according to claim 1 or 2,
The composition for preventing hair loss or promoting hair growth, wherein the composition is a food composition.
3. The method according to claim 1 or 2,
The composition for preventing hair loss or promoting hair growth, wherein the composition is a cosmetic composition.

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