KR101966021B1 - Process for processing food with herb and dried Rhus verniciflua - Google Patents

Abstract

The present invention relates to a method for preparing Toxicodendron vernicifluum bark and a pharmaceutical preparation containing prepared Toxicodendron vernicifluum bark. More particularly, the present invention relates to: the method for manufacturing Toxicodendron vernicifluum bark which is processing Toxicodendron vernicifluum bark by using oriental herb medicine and a specially manufactured extractor to reduce toxicity of Toxicodendron vernicifluum bark; and the pharmaceutical preparation containing prepared Toxicodendron vernicifluum bark. According to the present invention, it is possible to safely and effectively utilize useful components of Toxicodendron vernicifluum bark by reducing or neutralizing the toxicity of lacquer without using a bioconversion process.

Description

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a process for preparing a food containing herb and dried Rhus verniciflua,

More particularly, the present invention relates to a method for producing a food containing a phytogenic herb medicine and an extract of a dried bark, and more particularly, to a method for producing a herb medicine by reducing the toxicity of the lacquer by using a herbal medicine and a specially- The present invention relates to a method for producing a food containing an extract of dried bark.

Generally, lacquer refers to sap from Rhus verniciflua when a tree belonging to the lacquer tree is injured. There are 400 varieties of trees of 60 genera distributed in the subtropical or tropical regions of the lacquer tree. In Korea, there are five species such as lacquer tree, lacquer tree, and rush tree.

Such lacquer has been used as a coating material for metal or woodwork in Korea, China and Japan for a long time. In addition, lacquer is used as a medicinal material in one room, and its weakness is hot, spicy and toxic, It is said to have the efficacy of digestion, elimination and sterilization. It is mainly used for the eradication of umbilical cord blood, circulatory arrest, heartache, and insult. Major prescriptions include Gancil Circle, Gunnil San and Lee Sung Hwan.

However, as described above, the lacquer tree, which has many effects on various diseases of the human body, can induce allergic dermatitis and respiratory failure, and a person who has allergies to lacquer can use lacquer There is a problem in that the public can not obtain the beneficial effect of the lacquer tree because the public is afraid of taking the lacquer tree itself.

The poisonous substance that causes the allergy of the Rhus verniciflua is urushiol, which absorbs oxygen in the air by the action of laccase and becomes a black resinous form. The chemical structure of urushiol is a catechol compound having two hydroxyl groups in the benzene ring and having a long chain fatty acid having a carbon number of 15 bonded to the side chain (R). The number of the uriciol derivative Lt; / RTI > Ursiol is the main ingredient in the sap of lacquer trees native to Korea, China and Japan. However, lacquol is the main component of lacquer tree in Taiwan and Vietnam. It is mainly composed of laccol, which has 17 carbon atoms in catechol. In the sap of lacquer tree in Thailand and Myanmar, Unlike urushiol and lacol, thitsiol is known to be the main component, which binds at different positions.

On the other hand, Korean Patent No. 10-0547554 discloses a composition containing an extract of sea tangle, garlic and Rhus having anti-inflammatory activity, and recently, a substance (MU2) (Korean Patent No. 10-0257448).

In order to utilize the pharmacological and physiological activity of lacquer so far, it has been known to use a purification process in which lacquer is roasted at high temperature or carbonized at a high temperature of 200 ° C or higher in a closed kiln in order to neutralize the toxicity of urushiol. Process may result in eliminating the pharmacological action of lacquer by evaporating uriciol which is an allergen inducing ingredient of lacquer and its pharmacologically active ingredient.

In addition, according to the method of putting the lacquer into the chicken or duck, the jujube, the chestnut, the chestnut, and the lacquer which are used in the private sector, it is proved that various kinds of side effects such as dermatitis are found in one of the three people who ingest the lacquer chicken or the duck, Lt; RTI ID = 0.0 > toxicity < / RTI >

Korean Registration No. 10-1320149 (October 14, 2013) Korean Registration No. 10-1781940 (September 20, 2017) Korean Registration No. 10-1089176 (November 28, 2011) Korean Registration No. 10-1639567 (July 08, 2016) Korean Registration No. 10-1662936 (September 28, 2016) Korean Registration No. 10-0572405 (April 12, 2006)

The inventors of the present invention have conducted intensive studies to solve the problems of the prior art as described above and to develop a preparation having urushiol toxicity reduced to the maximum while also containing useful components of dry blood. As a result, The present inventors have found that it is possible to produce a dry or dry paper preparation in which the toxicity of the lacquer is reduced by formulating the dry lycopene using a specially developed extractor.

Accordingly, an object of the present invention is to provide a pharmaceutical preparation containing a dry matter extract of urushiol reduced toxicity of urushiol while containing the useful components of dry skin at a maximum, and a process for producing the same.

SUMMARY OF THE INVENTION [0006]

(a) A phytogenic herb medicine containing rhubarb, rhododendron, bud, barnyardgrass, rhododendron, gossypii and germ, and 5 to 20 times of purified water based on the weight of the herbal medicine are added to the extractor at a temperature of 0.5 to 0.6 atm and 70 to 80 ° C 60 to 72 hours;

(b) boiling water at a temperature of 100 to 150 ° C for 3 to 48 hours to evaporate water vapor,

(c) condensing the evaporated water vapor to obtain an LOHO extract;

(d) extracting the dried kraft pulp from the extractor and drying it;

(e) pulverizing the dried gunpowder;

(f) mixing the rhubarb extract with Gunsovia powder;

(g) formulating the mixed mixture obtained in the above step; And

and (h) packaging the formulated raspberry extract.

According to the present invention, it is possible to safely and effectively utilize useful components of dry skin by reducing or neutralizing the toxicity of the lacquer without using the biological conversion process.

BRIEF DESCRIPTION OF THE DRAWINGS FIG. 1 is a process diagram for the preparation of a dry loaf according to the present invention; FIG.
2 is a front view of the extractor according to the present invention.
3 is a rear view of the extractor according to the present invention.
4 is an internal perspective view of a stirring tank of an extractor according to the present invention.
5 is a view for explaining rotation of a stirring blade of the stirring tank.
6 is a side view for explaining the rotation of a stirring blade of the stirring tank.
Fig. 7 is a graph showing the effect of the extract of the dried liquorice extract on LPL activity.
FIG. 8 is a graph showing the anticancer activity of the extract of dried bonito according to the present invention.

In one aspect of the present invention,

(a) A phytogenic herb medicine containing rhubarb, rhododendron, bud, barnyardgrass, rhododendron, gossypii and germ, and 5 to 20 times of purified water based on the weight of the herbal medicine are added to the extractor at a temperature of 0.5 to 0.6 atm and 70 to 80 ° C 60 to 72 hours;

(b) boiling water at a temperature of 100 to 150 ° C for 3 to 48 hours to evaporate water vapor,

(c) condensing the evaporated water vapor to obtain an LOHO extract;

(d) extracting the dried kraft pulp from the extractor and drying it;

(e) pulverizing the dried gunpowder;

(f) mixing the rhubarb extract with Gunsovia powder;

(g) formulating the mixed mixture obtained in the above step; And

and (h) packaging the formulated raspberry extract.

The present invention, in a further aspect,

The content of rhubarb, rhododendron, rosemary, barnyardgrass, rhizoma, guerrilla, persimmon and crudacea is 50 to 70 parts by weight, rhizome 120 to 140 parts by weight, bud 80 to 120 parts by weight, , 70 to 110 parts by weight of guar gum, 100 to 140 parts by weight of gum arabic, and 500 to 2,000 parts by weight of dried gum.

The present invention, in a further aspect,

Wherein the mixing ratio of the lacquer extract and the dried lychee powder is 1 to 99: 99 to 1 part by weight.

The present invention, in a further aspect,

The extractor used in the step (a)

A stirring tank (100) for heating and stirring the raw material to generate and concentrate steam;

A steam conveying pipe 200 connected to the upper portion of the stirring tank 100 to convey the generated steam;

A cooling unit 300 connected to the steam transfer pipe 200 to cool the transferred steam;

A condensed water storage tank 350 connected to a downstream end of the cooling unit 300 to store condensed water condensed by the cooling unit 300;

A vacuum pump 400 provided at a lower end of the condensed water storage tank 350 for maintaining the cooling unit 300 and the condensed water storage tank 350 in a vacuum state; And

And a control unit (500) for controlling the overall operation and function of the apparatus.

BRIEF DESCRIPTION OF THE DRAWINGS The above and other features and advantages of the present invention will be more apparent from the following detailed description taken in conjunction with the accompanying drawings, in which: FIG.

It is to be understood that the words or words used in the present specification and claims are not to be construed in a conventional or dictionary sense and that the inventor can properly define the concept of a term in order to describe its invention in the best possible way And should be construed in light of the meanings and concepts consistent with the technical idea of the present invention. Therefore, it should be understood that the embodiments described herein and the configurations shown in the drawings are only the most preferred embodiments of the present invention, and that various equivalents and modifications may be substituted for them at the time of the present application shall.

In order to more easily explain the present invention, conventional valves and piping are not shown. However, even if these valves and piping are not explicitly described in the technical field of the present invention, Which may be included in the components of the present invention as part of a conventional device.

FIG. 1 is a process diagram for carrying out a method for preparing a dry cream according to the present invention. As shown in FIG. 1, the method for preparing dry loaf according to the present invention can be roughly classified into a herbal medicine extracting step, a dry loaf extracting step, a condensing step, a drying step, a pulverizing step, a formulation step, and a packaging step. Each step will be described in detail below.

(a) step of extracting the herbal medicines

In this step, phytogenic herb medicines containing rhubarb, rhododendron, rosemary, ginseng, goat, goat, and guinea are added to the extractor to be described later and 0.5 to 0.6 atm and 70 to 80 Wherein the individual contents of the rhubarb, rhododendron, bud, barnyardgrass, rhododendron, rhizome and rhizome are 50 to 70 parts by weight, 120 to 140 parts by weight, 80-120 parts by weight of barley, 80-120 parts by weight of sorghum, 70-110 parts by weight of guar gum, 100-140 parts by weight of corn.

The present invention has been made with a view to develop a preparation having various functions with a view to optimizing the efficacy of dry skin by using various herbal medicinal herbs with a few side effects. Various herbal medicinal herb ingredients and their combination ratio, And the taste of the product. The composition ratio of the phytogenic herb according to the present invention is determined by taking into account the pharmacological activity inherent to the dry loaf, while minimizing the toxicity due to the dry loaf, And if it exceeds the range of the ratio, it is not possible to exhibit desirable harmony or synergistic effect with the inert ingredient and the effect may be deteriorated.

Rheum palmatum Linne is the root and rootstock of Polygonaceae and has been removed. The effect of excessive heat accumulated in the body to lower the skin, constipation, constipation, hypertension, treatment of hyperemia and pain. It is also used for early symptoms of dysentery. It is also effective for fever, nosebleeds and acute jaundice due to heat. It is widely used for symptoms such as fever, pain, severe redness, and hot burns. In addition, when the flour is applied to the bronchial flora which is generated in winter, it is excellent in anti-inflammatory action and the wound is easily healed.

Persicae semen (Scientific name: Prunus persica (L.) Batsch) is used as a medicinal herb by drying mature seeds of peaches. It has the effect of activating bovine leukocyte It can be applied to the symptoms caused by most blood vessels (瘀血 inhibition). At this time, in the present invention, it is preferable to shredded (cooked) and to live.

Sprout barley refers to a young plant that grows about 10 to 15 cm in length with buds planted in barley. It is known as a good source of nutrients because of high content of inorganic substances such as calcium, magnesium and potassium as well as a high content of vitamin B1 and vitamin C, and also has antioxidant, anti-inflammatory and anti-cancer saponin saponarin, lutonarin, and isovitexin, and thus their industrial applicability as health functional foods and medicines has increased. This ingredient has the function of alleviating or neutralizing the toxicity caused by the herbal medicines such as Gunpowder.

The seed barley may be grown in the open field or may be obtained by dipping the barley in water for one day, then removing the moisture and preventing water loss, germinating the barley for 10 to 14 days have.

Sansa is a fruit of hawthorn tree containing diverse organic acids, flavonoids and vitamin C, and has the effect of strengthening blood vessels and cardiac function. It is prescribed for postpartum abdominal pain, hangover, dryness, indigestion and chronic diarrhea.

It is a word that leads to licorice which alleviates the weakness and slightly changed by burning in fire. It is warm when the licorice is baked. It is used to show the masturbation, to help the heart, to show the symptom of heartbeat and chest pounding due to shortage of heart, lack of heart sound and shortness of heart, hysterical symptoms, and it is used to stabilize the mind. Depression, hysteria). It also acts on the lungs to remove the follicles, stop the cough, and relieve stomach cramps and spasm of the limb muscles and relieve pain.

The law means rice washed (rice flakes) and neutralizes the other ingredients added. In the present invention, it is possible to collect rice washed by pouring the same amount of water into the rice and washing it after being called for 30 minutes and repeating it three times.

These ingredients are aimed at alleviating the toxic effects of rosemary blooms and resolving the accompanying symptoms, which include rhubarb, doen, sprouts, barnyardgrass, guerrilla, and lawful herb.

More specifically, the herbal medicine is preferably subjected to hot air drying at a temperature of 55 to 65 ° C for the purpose of pre-treatment.

Of course, the herbal medicines may be extracted individually after individual pretreatment, or may be prepared by collecting the whole raw materials at once and collecting them all at once.

Subsequently, purified water of 5 to 20 times the weight of the dried herbal medicine is added, and extracted at a temperature of 0.5 to 0.6 atm and 70 to 80 ° C for 60 to 72 hours to obtain an extract.

In the above process, purified water or water is used as an extraction solvent for convenience. However, the present invention is not limited to this, and at least one selected from a lower alcohol having 1 to 4 carbon atoms, a polyhydric alcohol, or a mixture thereof may be used. As the lower alcohol having 1 to 4 carbon atoms, methanol, ethanol and the like can be used. As the polyhydric alcohol, butylene glycol, propylene glycol, pentylene glycol and the like can be used. Mixtures of water and lower alcohols, mixtures of water and polyhydric alcohols, mixtures of lower alcohols and polyhydric alcohols, or mixtures of water and lower alcohols and polyhydric alcohols can be used as the mixture.

As a result of the experiment, it was found that the herbal medicinal herb extract was more efficient than the high temperature extraction at 60 ℃ ~ 70 ℃ for low temperature or medium temperature extraction. In addition, the extracts extracted from 60 ℃ ~ 70 ℃ showed the highest contents of various oriental medicinal ingredients. When the extracts were extracted above 80 ℃, the content of active ingredients decreased.

The extraction time for extraction of oriental medicinal herb was the highest when the extract was extracted for 72 hours, and the extract solid content and the active ingredient content tended to be lower when the extraction time exceeded 72 hours.

On the other hand, the amount of extraction solvent showed good results when it was extracted with 5 ~ 20 times of the experimental results for standardization of the amount of solvent, and it is most effective to extract by adding 10 times of solvent when considering energy efficiency and economy. The extraction pressure is preferably carried out under the condition of 0.5 to 0.6 atm.

If necessary, the extraction efficiency may further be increased by further extracting at a temperature of 0.8 to 0.9 atm and a temperature of 70 to 80 ° C for 60 to 72 hours.

(b) Tissue evaporation step

Then, as described above, in the state where the water vapor is not evaporated from the herbal medicine herbal medicine, the extract is extracted so that the active ingredient of herbal medicine is sufficiently extracted, and then the extractor is pulverized with boiling water at 100 to 150 ° C for 3 to 48 hours to evaporate the water vapor .

It is preferable that the dried crumb be used at a weight ratio of about 1: 1 to 5 of the herbal medicine and 500 to 2,000 parts by weight based on 500 parts of the phytogenic herb medicine.

The dried bloom is a dry lacquer shell, which removes the most powerful of the botanical herbs. It cuts off ejaculation, stops menstruation, and causes acid abstinence. It is used to make the small intestine well and to eliminate roundworms. Therefore, lacquer cleanse blood, regenerates deteriorated cells in a healthy way, and has the pharmacological effect of blocking oxidized cells.

The active ingredients of lacquer can be very helpful in treating diabetes, cancer, hyperlipidemia, hypertension, heart disease, arthritis, skin diseases, neuralgia, obesity, etc. It is also warm and has a strong detoxifying effect, which is very effective in treating chronic gastritis, gastrointestinal diseases, menstrual cramps, poor circulation and liver diseases. Functionally, they are resistant to acid, acid, salt, heat, waterproof, antiseptic, anti-insecticidal, , And excellent insulation strength. Because of this, lacquer woods, which were made a thousand years ago, are excavated in the ground or in water without corroding. It is possible to cultivate lacquer throughout the country and its quality is the best in the world. In addition, the world's only lacquer has been utilized in a variety of edible and medicinal uses.

When the body is cold and the blood is tangled because the tiles and blood are not purified well, the bad blood is the bud and the old blood is the communication and the ejaculation. Therefore, because the body is cool and prevents coldness, the amount of urine is increased and it is excreted well. The excretion of urine and the amount of it means that the liver, kidneys, and bladder become energetic.

When the body is cold and the blood is tangled because the tiles and blood are not purified well, the bad blood is the bud and the old blood is the communication and the ejaculation. Therefore, because the body is cool and prevents coldness, the amount of urine is increased and it is excreted well. The excretion of urine and the amount of it means that the liver, kidneys, and bladder become energetic. Active oxygen triggers cancer, and the "tocopherol component" embedded in the lacquer is 20 times that of vitamins.

(c) Condensation stage

Then, the evaporated water vapor is condensed in the cooled state to obtain an LOHO extract.

(d) drying step

On the other hand, the remaining kraft pulp is removed from the extractor and dried separately. The drying process can be naturally dried in a well-ventilated state or by blowing hot air at a temperature of 35 to 45 ° C for 4 to 8 hours through a dry air nozzle.

(e) Powdering step

Then, the dried gunpowder is pulverized to a particle size of 80 to 200 mesh. Finely milled into about 150 meshes.

(f) mixing step

The mixing ratio of the lacquer extract and the dried lychee extract may be selected within the range of 1 to 99:99 to 1 part by weight.

There is a person who does not have allergic reaction according to the human body, but there is a person who does not have it. Even if 100% of the undiluted solution is used, the person can get the pharmacological effect directly. However, It is necessary to use a mixture of the crude extract and the dried bloody powder by varying stepwise from 1% to 99%.

(g) Formulation step

In the step of formulating the mixed mixture obtained in the above step, the dry powdery extract is formulated into a pharmaceutical acceptable mixture.

The pharmaceutical preparations thus prepared exhibit various functionalities such as lowering of lipid content and anticancer effects as shown in the examples described later, and thus they are useful as medicines for improving or treating related diseases, Can be usefully used. It may be desirable to use the pharmaceutical formulation especially as a ring or powder.

The pharmaceutical composition of the present invention may be administered by any of the parenteral preparations such as oral agents, injections, and spot-applying agents.

The pharmaceutical preparation according to the present invention can be formulated in combination with a known pharmaceutical carrier. Generally, the active ingredient is mixed with a pharmaceutically acceptable liquid or solid carrier and, if necessary, a solvent, a dispersant, an emulsifier, a buffer, a stabilizer, an excipient, a binder, a disintegrant, a surfactant, And a liquid agent such as a solid agent such as tablets, granules, powders, powders and capsules, a liquid agent, a suspending agent, an emulsion or the like can be used. It may also be a dried product which can be made into a liquid phase by the addition of a suitable carrier before use.

The pharmaceutical carrier can be selected in accordance with the above administration form and formulation, and in the case of an oral preparation, for example, starch, lactose, white sugar, mannit, carboxymethylcellulose, konstach, inorganic salt and the like are used. On the other hand, in the case of the parenteral preparation, the composition containing the ruschokinetic extract of the present invention as an active ingredient of the present invention can be used as a diluent in distilled water for injection, physiological saline solution, glucose aqueous solution, vegetable oil for injection, sesame oil, Propylene glycol, polyethylene glycol and the like, and if necessary, adding a bactericide, stabilizer, isotonizing agent, an anhydrous agent and the like.

The pharmaceutical composition of the present invention is administered by an appropriate route according to the form of the preparation. The method of administration is not particularly limited, and it can be administered by the contents, external application and injection. The injection can be administered, for example, intravenously, intramuscularly, subcutaneously, intradermally, and the like.

The dosage of the pharmaceutical and food preparations of the present invention is appropriately set according to the form of the pharmaceutical preparation, the method of administration, the purpose of use, and the age, weight and symptom of the individual to which the active ingredient is applied. For example, 25 mg to 5,000 mg / kg per day. Of course, since the dosage varies depending on various conditions, the amount may be less than the above amount, or may be more than the above range.

The food preparation according to the present invention can use auxiliary ingredients of the food according to the form of the desired preparation, and their combination ratio and the like can be employed without special technical difficulties as those commonly used in the art.

Or a sweetening agent such as honey, malt, glycerin, red ginseng, cordyceps, grapefruit extract, licorice, pulverized medicinal lobule powder, wolfberry extract, St. John's Wort, selenium yeast, vitamin C, citric acid, nicotinic acid, benzoic acid One or more ingredients selected from the group consisting of sodium, aspartame, saccharin, pectin, maltitol, sorbitol, xylitol, guar gum, skim milk powder and oligosaccharide may be added to increase taste and aesthetics. They are suitably used at about 50-80% based on the total weight of the formulation of the present invention.

The food composition according to the present invention may be provided in the form of beverage such as, for example, tablet, capsule, confection or drink.

The beverage can be, for example, 0.1 to 30% by weight of the herbal medicinal herb and the extract of the dried bark, 0.01 to 2% of citric acid, and vitamins such as vitamin C, vitamin B1 and biotin, and 0.01 to 2% Functional beverage is produced.

(h) Packaging step

The formulated ricotta extracts are packaged in a unit by conventional methods. In addition, it may be preferable to put a certain amount of product into an aluminum pack, a nylon laminate, a laminating pack or a PET resin container, and seal the laminate with a silica gel.

Meanwhile, the extractor used in the steps (a) and (b) includes a stirring tank 100 for heating and stirring the raw material to generate and concentrate the steam. A steam conveying pipe 200 connected to the upper portion of the stirring tank 100 to convey the generated steam; A cooling unit 300 connected to the steam transfer pipe 200 to cool the transferred steam; A condensed water storage tank 350 connected to a downstream end of the cooling unit 300 to store condensed water condensed by the cooling unit 300; A vacuum pump 400 provided at a lower end of the condensed water storage tank 350 for maintaining the cooling unit 300 and the condensed water storage tank 350 in a vacuum state; And a control unit (500) for controlling the overall operation and function of the apparatus.

FIG. 2 is an explanatory front view of a herbal medicine extractor according to the present invention, FIG. 3 is a rear explanatory view of a herbal medicine extractor according to the present invention, FIG. 4 is an inner perspective view of a stirring tank of a herbal medicine extractor according to the present invention, FIG. 6 is a side view for explaining the rotation of a stirring blade of the stirring tank. FIG.

The herbal medicine extracting apparatus according to the present invention includes a stirring tank 100, a steam conveying pipe 200, a cooling unit 300, a condensed water storage tank 350, a vacuum pump 400, a control unit 500, And the like.

The stirring tank 100 includes a housing 101 having a horizontal cylindrical shape. The housing 101 provides space for generating and concentrating the steam by heating and stirring the raw material. The stirring tank 100 is a conventional vertical stirring tank As described later, the stirring wing 170 and the scraper 190 coupled thereto are horizontally positioned to rotate about the stirring shaft 170 driven by the motor 150, So that the introduced raw material does not remain on the inner surface of the housing 101 and is prevented from adhering to the surface of the housing 101 so as to adhere to the surface of the unrolled raw material, Thereby solving the problem associated with the conventional vertical stirring tank which causes inefficiency of the apparatus.

The conventional vertical stirring tank has a fundamental limitation in realizing a stirring trajectory that maximally covers the cylindrical internal structure even if the stirring shaft is vertically or inclined and a plurality of stirring blades are disposed on the stirring shaft and rotated.

A raw material input port 120 is formed in a circular shape at an upper side of the housing 101 and a lid 110 for opening and closing the raw material input port 120 is formed corresponding to the shape of the raw material input port 120. The opening and closing of the lid 110 can be performed by rotation of the hinge shaft 113 by tightening and loosening of the plurality of fasteners 112 and a viewing window 111 is provided at the upper portion to grasp the progress of the inside, If necessary, a pressure gauge and a pressure reducing valve may be installed. The pressure provided at this time can be added below 1 atm.

At the lower outer end of the housing (101), a discharge valve (140) is provided with stirring to discharge liquid, semi-solid and jelly-like solids.

A steam pipe (130) for supplying steam to the outside of the housing (101) is provided to surround the housing (101).

The heat of steam supplied by the steam tube 130 indirectly provides heat to the outside of the housing 101, thereby providing the effect that the introduced raw material is stirred without being adhered to the inner surface. In addition, the use of steam also has the advantage of easier installation and maintenance of the device.

A rotating shaft 170 driven by a motor 150 is installed at the center of the housing 101 and horizontally installed with parts such as a bearing and a supporting structure provided at both ends of the housing 101. A rotating blade 180 is mounted on the rotating shaft 170, A plurality of rotation shafts 170 can be moved and adjusted. For example, the rotary vane 180 can be mounted on the rotary shaft 170 by providing a hole at the center of the rotary shaft 170 so that the rotary vane 180 can be positioned on the rotary shaft 170 and can be extrapolated or provided with a hole that can be opened and closed by bolts.

A scraper 180 is detachably coupled to an end of the rotary vane 180 to allow the introduced raw material to be stirred with a maximum rotation locus. For example, the scraper 190 is a long rod-shaped or plate-like structure (for example, a bulldozer blade), and a plurality of coupling grooves are formed at the end of the rotary vane 180, (Not shown) can be used to fasten screws or the like. In this embodiment, the fastening configuration is not critical, but the angle of rotation of the fastened scraper 190 and the height of the scraper may be very important. Accordingly, although not limited thereto, the angle of engagement between the rotary vane 180 and the scraper 190 may be preferably 45 to 135 ° from the side view. It is also desirable that the height of the scraper be as high as possible.

On the other hand, the inner surface of the housing 101 is coated with a coating material which is not harmful to the human body and is resistant to friction between high temperature and rotation, including a Teflon material, so that the durability and agitation efficiency of the apparatus can be further improved.

The motor 150 is connected by a pulley 152 to rotate the rotation shaft 170 by the operation of a gear.

A motor 150 is positioned below the rear surface of the housing 101 and the rotating force of the motor is transmitted to the rotating shaft 170 by a pulley 160.

The rotation speed of the stirring wing can be controlled by a control unit 500 described later, and is adjustable as required within a range of typically 5 to 100 rpm.

It is preferable that the structure of the motor 150 and the pulley 160 is not exposed to the outside using a cover in terms of stability of operation and the like.

The stirring tank 100 may be supported by a plurality of horizontal and vertical supports 102 and the support 102 may be fixedly mounted on the baffle 600.

The bogie plate may include a base plate 610 and a vibration damping base 620 including elastic means.

According to the structure and configuration of the stirring tank 100, the raw material and the processed material, which have been stirred and processed, can be discharged through the discharge valve 140. At this time, The discharge can be made easier.

The steam transfer pipe 200 is connected to the upper portion of the stirring tank 100 via the steam discharge valve 145 and the steam generated by the heating and stirring of the stirring tank 100 is supplied to the cooling unit 300 Transfer.

The cooling unit 300 is provided with a steam extracting valve 145 connected to the steam conveying pipe 200 for opening and closing the steam discharging valve 145 and cooling the steam by circulating the cooling water, Lt; / RTI >

The cooling unit 300 functions to cool the steam transferred through the steam transfer pipe 200. Basically, the cooling unit 300 is a device for cooling the steam transferred through the coil, In order to increase the cooling efficiency, a plurality of coolers may be used. For example, as shown in FIG. 1, the first cooler 310, the second cooler 320, and the third cooler 330 are sequentially connected by a connection pipe. The inside of these coolers is formed into a structure in which coil-shaped tubes which are condensed by indirect contact with cooling water while passing through steam are spirally arranged and cooling water flows to the outer surfaces of the tubes. .

The cooling water flows into the inlet port 340 provided in the lower portion of the third cooler and circulates through the outlet port 341 provided in the first cooler.

Then, the condensed water condensed in the cooling unit 300 is introduced into the condensate water recovery tank 350, stored therein, and then discharged through the condensate discharge valve 351 to be used for the required purpose.

The condensate storage tank 350 is connected to the rear end of the cooling unit 300 and stores the condensed water condensed by the cooling unit 300.

A cleaning cap 351 is provided at one side of the upper part of the condensed water storage tank 350 so as to clean the interior of the condensate water tank 350. The water level check pipe 353 and the sight glass tubes 430 and 431 You can check the internal state.

In order to efficiently perform cooling and condensation of the steam, the decompression state provided by the vacuum pump 400 is provided and maintained in the cooling unit 300 and the condensate collection tank 350, thereby further improving the efficiency of the extraction process .

The vacuum pump 400 is provided at the lower end of the condensed water storage tank 350 and maintains the cooling unit 300 and the condensed water storage tank 350 in a vacuum state. The vacuum state can be confirmed by a vacuum control gauge provided adjacent to the vacuum regulating and releasing valve 420. In the vacuum regulating and releasing valve 420,

The cooling unit 300 and the condensate recovery tank 350 and the vacuum pump may be supported by horizontal and vertical supports 360 and valves and gauges connected to the vacuum pump may be connected to the condensate discharge It is not necessary to arrange them on the same plane so as not to overlap with the related components.

In the herbal medicine extractor according to the present invention, the overall operation and function of the apparatus is controlled by the control unit (500).

The control unit 500, which is a main component for achieving the present invention, includes a control substrate. The control unit 500 controls the heating temperature of the stirring tank 100 and controls the operation of the rotating shaft 170, And controls the pressure inside the stirring tank 100 and the operation of the condensate recovery tank 350 and the vacuum pump 400. [

The control unit 500 of the present invention controls the cooling unit 300. More specifically, the control unit 500 displays the temperature of the control or cooling water so as to supply or discharge the cooling water, and controls the circulation of the cooling water.

The control unit 500 includes an input unit (not shown) and a display unit (not shown). The control unit 500 controls the temperature and operation time of the user, 170, and the like, and the stored information, and controls the configurations of the present invention.

Hereinafter, the operation mode of the herbal medicine extracting apparatus capable of simultaneously performing the concentration and extraction according to the present invention will be described.

When the herbal medicine raw material is introduced into the inlet 120 and an extract containing the effective ingredient is obtained, the raw material is heated and stirred in the stirring tank 100 to generate steam containing the effective ingredient, if necessary, The steam moving through the condenser 200 is condensed through the cooling unit 300 and is collected in the condensate collection tank 350 and extracted as an extract.

On the other hand, when it is desired to evaporate water only from the raw material to obtain a solid concentrate, steam is generated by heating and stirring the raw material in the stirring tank 100, and the solid concentrate concentrated to a necessary degree is discharged to the concentration valve 140 . The generated steam is conveyed through the steam conveying pipe 200 so that the steam is condensed through the cooling unit 300 and collected in the condensate collecting tank 350 and then discharged.

Therefore, when extracting oil containing fragrance or general oil from a plant or the like, the raw material and distilled water are charged in the stirring tank 100, heated and stirred, and the generated vapor is liquefied in the cooling unit 300 in a vacuum state, When the water and oil are collected in the tank 350, the oil and the oil can be extracted sequentially by extracting water and oil. That is, the present invention has an advantage in that plants and the like can be processed without breaking the active ingredient by stirring and mixing plants and the like in a low-temperature vacuum state.

<Examples>

Hereinafter, the present invention will be described in more detail with reference to Examples. It is to be understood by those skilled in the art that these embodiments are only for describing the present invention in more detail and that the scope of the present invention is not limited by these embodiments in accordance with the gist of the present invention .

Example 1: Preparation of an extract of dried bran extract

200 g of purified water was added to the herbal extractor and mixed at a temperature of 80 ° C under a pressure of 0.5 atm and at a temperature of 80 ° C. The herbal medicinal herbs were 600 g, 600 g, 1400 g, 1000 g, 1000 g, 1000 g, Lt; / RTI &gt; The rice was poured with the same amount of water, washed for 30 minutes, washed three times, and washed.

Subsequently, 6 Kg of dried bran was added to the extractor, and the mixture was boiled at a temperature of 120 ° C. for 24 hours to evaporate the water vapor, and the evaporated water vapor was condensed to obtain 155 g of an extract of RVOK. On the other hand, after the extraction, the remaining crumbs were taken out, dried in a well-ventilated shade, and then pulverized into 150 mesh. The lacquer extract and Gunpowder flour were mixed at a weight ratio of 1: 1 and used as a raw material for formulation.

Example 2: Preparation of an extract of dried bran extract

The same procedure as in Example 1 was carried out except that the mixing ratio of the lacquer extract and the dried liquorice was 2: 1 to prepare the dried liquorice extract.

Example 3: Preparation of an extract of dried bonito extract

The same procedure as in Example 1 was carried out except that the mixing ratio of the lacquer extract and the dried liquorice was 1: 2 to prepare the dried liquorice extract powder.

Example 4: Production of pills

The extracts of 7% (by weight) maltose powder, 3% maltitol powder, 3% citric acid, 7% citric acid, 10% sorbitol, 35% xylitol and 15% After 25 minutes of mixing, they were combined using a coater, and the mixture was air-conditioned. After drying at about 30 캜, hydroxypropylmethylcellulose was dissolved in 95% alcohol, spray-coated, and dried 30 ㅁ After drying for 1 hour at 2 ° C with moisture content of 5% or less, packed (PS) to prepare a pellet having an amount of 3.5 g.

Example 5: Tablet formulation

(Example 1) 25 mg

Lactose 60 mg

Starch 15 mg

Magnesium stearate 15 mg

Crystalline cellulose 15 mg

Tablets may be prepared by conventional methods and one preferred embodiment is in the form of tablets or soft capsules with conventional enteric coatings (e. G., Hydroxypropylmethylcellulose phthalate), sugar coating or coatings.

Example 6: Preparation of beverage

20 g of citric acid, 17 g of aspartame and 30 g of vitamin C were added to 100 g of the dry powdery preparation obtained in Example 1, and the remaining was added with purified water to make 10 L of drinking water and pasteurized. As a result, the beverage of the present invention obtained favorable responses to conventional beverage products in terms of mouth feel, taste, and overall evaluation.

Example 7: Manufacture of pouch

Pouches Pouches were prepared by an automatic filling machine so that 10 g of vitamin C, 10 g of aspartame, and 50 g of purified water were contained in 40 g of the extracted ganoderma lucid powder obtained in Example 1.

Example 8 Acute Toxicity Test

The toxicity test of the extract of the dried bonito extract according to the example of the present invention was conducted and its toxicity was observed. The experimental animals were 60 male SD male rats weighing 105 ~ 4g and 95 ~ 3g female at 4 and 5 weeks of age and were tested using distilled water as the negative control and the preparation of the present invention. First, the rats were incubated in a laboratory incubation box with a light and dark cycle of temperature 22 ± 2 ° C., relative humidity 53 ± 2% and fluorescent light (09:00 lit-18: 00 off) and illumination conditions of 150-300 Lux, The animals were divided into groups in which the average body weight was matched. Animals were orally administered at a dose of 20 ml / kg once a day for 14 days, and the change in general condition, poisoning symptom , Mobility, appearance, autonomic nervous system, weight change, and presence of dead animals.

According to the experimental results, there was no significant difference in the body weight during the experimental period, but there was no significant difference. The highest concentration of 20 ml per kg, which is the maximum amount of sample to be administered to the test animal, was selected, LD ₅₀ was found to be more than 20 ml / kg BW because of the inability to calculate the lethal dose. As a result, it was found that the extract of Gunungulpy extract was not toxic.

Example 9: Anti-hyperlipidemic effect test

In order to confirm the effect on the hypertriglyceridemia of the extract of dried bonito according to the examples, 7F2 cells were proliferated on a 75 cm culture flask using DMEM as a standard medium to promote adipogenesis, and on the 6th day of culture, Nilsson Lipoprotein lipase (LPL) activity was measured according to the method of Ehle and Schotz (1976, J Lipid Research, 17: 536-541) and the results are shown in FIG.

Fig. 7 is a graph showing the effect of the extract of the dried liquorice extract on LPL activity. As a result, a slight activity was observed in the control group not treated with the herbal medicine, but the activity of the lipoprotein lipase was significantly increased in the test groups of Examples 1 to 3 as compared with the control group. .

Example 10: Test for measuring anticancer activity

In order to investigate the anticancer activity of the extract of the dried bonito extract of the examples of the present invention, anticancer activity was measured using normal cells (NIH3T3), A549 (lung cancer), AGS (stomach cancer), HT-29 (colon cancer) and HepG2 Measurement tests were performed. FIG. 8 shows the results of measuring the inhibitory activity of A549 (lung cancer), AGS (stomach cancer), HepG2 (liver cancer) and HT-29 (colon cancer) by inhibiting the growth of cancer cells by fixing the concentration of the sample to 50 μg /

FIG. 8 is a graph showing the anticancer activity of the extract of dried bonito according to the present invention. From the results of FIG. 8, the control group in which the herbal medicine extracting process was omitted showed some anti-cancer activity. However, the extract of the dried K. rubrum according to the present invention showed a slight inhibitory activity, .

Through this experiment, the pharmaceutical preparations prepared using the extract of dried bonito extract according to the present invention exhibited beneficial functions such as anti-hyperlipemia and anti-cancer activity as well as being safe for the users due to reduced toxicity of urushiol, It can be confirmed that it can be efficiently used for a consumer or a patient who needs the product.

It will be apparent to those skilled in the art that various modifications and variations can be made in the present invention without departing from the spirit or scope of the invention as defined in the appended claims. It will be clear to those who have knowledge.

100: stirring tank 101: housing
111: view window 130: steam tube
145: steam discharge valve 200: steam transfer pipe
300: Cooling section 350: Condensate recovery tank
400: Vacuum pump 500: Control unit
600:

Claims (5)

(a) A phytogenic herb medicine containing rhubarb, rhododendron, bud, barnyardgrass, rhododendron, guar, herb and rosemary is added to the extractor at a rate of 0.5 to 0.6 atm and at a temperature of 70 to 80 ° C 60 to 72 hours;
(b) boiling water at a temperature of 100 to 150 ° C for 3 to 48 hours to evaporate water vapor,
(c) condensing the evaporated water vapor to obtain an extract of the plant herb medicine and lacquer;
(d) extracting the dried kraft pulp from the extractor and drying it;
(e) pulverizing the dried gunpowder;
(f) mixing the plant herb medicine with the extract of lacquer and the dry lycopene powder;
(g) Formulating the mixed mixture obtained in the above step in the form of tablets, capsules, pills, pouches or drinks; And
(h) packaging the formulated preparation. &lt; Desc / Clms Page number 20 &gt; The method according to claim 1,
The content of rhubarb, rhododendron, rosemary, barnyardgrass, rhododendron, guerrillosaccharomyces sieboldii, rhubarb, rhubarb, and crustacea is 50 to 70 parts by weight, rhizome 120 to 140 parts by weight, bud 80 to 120 parts by weight, , 70 to 110 parts by weight of guar gum, 100 to 140 parts by weight of gum arabic, and 500 to 2,000 parts by weight of gum arabic. The method according to claim 1,
Wherein the mixing ratio of the lacquer extract and the dried lychee powder is 1 to 99: 99 to 1 part by weight. The method according to claim 1,
The extractor used in the step (a)
A stirring tank (100) for heating and stirring the raw material to generate and concentrate steam;
A steam conveying pipe 200 connected to the upper portion of the stirring tank 100 to convey the generated steam;
A cooling unit 300 connected to the steam transfer pipe 200 to cool the transferred steam;
A condensed water storage tank 350 connected to a downstream end of the cooling unit 300 to store condensed water condensed by the cooling unit 300;
A vacuum pump 400 provided at a lower end of the condensed water storage tank 350 for maintaining the cooling unit 300 and the condensed water storage tank 350 in a vacuum state; And
And a control unit (500) for controlling the overall operation and function of the apparatus. A functional food produced by the method according to claim 1 and having an antihyperlipidemic or anticancer effect function.

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