KR101954389B1 - 조절가능한 프로모터 - Google Patents

조절가능한 프로모터 Download PDF

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KR101954389B1
KR101954389B1 KR1020147009284A KR20147009284A KR101954389B1 KR 101954389 B1 KR101954389 B1 KR 101954389B1 KR 1020147009284 A KR1020147009284 A KR 1020147009284A KR 20147009284 A KR20147009284 A KR 20147009284A KR 101954389 B1 KR101954389 B1 KR 101954389B1
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seq
promoter
sequence
poi
carbon source
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KR20140069112A (ko
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디트하드 마타노비치
브리지트 개서
마이클 마우러
롤랜드 프리엘호퍼
요아힘 클라인
자나 웽거
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론자 리미티드
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
    • C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
    • C12N15/815—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts for yeasts other than Saccharomyces
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/37—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi
    • C07K14/39—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi from yeasts
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/635—Externally inducible repressor mediated regulation of gene expression, e.g. tetR inducible by tetracyline
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/67—General methods for enhancing the expression
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
    • C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0008—Oxidoreductases (1.) acting on the aldehyde or oxo group of donors (1.2)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y102/00—Oxidoreductases acting on the aldehyde or oxo group of donors (1.2)
    • C12Y102/01—Oxidoreductases acting on the aldehyde or oxo group of donors (1.2) with NAD+ or NADP+ as acceptor (1.2.1)
    • C12Y102/01012—Glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) (1.2.1.12)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/55—Fab or Fab'
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02E—REDUCTION OF GREENHOUSE GAS [GHG] EMISSIONS, RELATED TO ENERGY GENERATION, TRANSMISSION OR DISTRIBUTION
    • Y02E50/00—Technologies for the production of fuel of non-fossil origin
    • Y02E50/10—Biofuels, e.g. bio-diesel

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
KR1020147009284A 2011-10-07 2012-10-05 조절가능한 프로모터 Active KR101954389B1 (ko)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201161544451P 2011-10-07 2011-10-07
US61/544,451 2011-10-07
EP11184323.1 2011-10-07
EP11184323 2011-10-07
EP12171006.5 2012-06-06
EP12171006 2012-06-06
PCT/EP2012/069757 WO2013050551A1 (en) 2011-10-07 2012-10-05 Regulatable promoter

Related Child Applications (1)

Application Number Title Priority Date Filing Date
KR1020197005781A Division KR102128957B1 (ko) 2011-10-07 2012-10-05 조절가능한 프로모터

Publications (2)

Publication Number Publication Date
KR20140069112A KR20140069112A (ko) 2014-06-09
KR101954389B1 true KR101954389B1 (ko) 2019-03-06

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KR1020147009284A Active KR101954389B1 (ko) 2011-10-07 2012-10-05 조절가능한 프로모터
KR1020197005781A Active KR102128957B1 (ko) 2011-10-07 2012-10-05 조절가능한 프로모터

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US (4) US9512432B2 (enExample)
EP (2) EP3508494B1 (enExample)
JP (1) JP6113736B2 (enExample)
KR (2) KR101954389B1 (enExample)
CN (3) CN110055248A (enExample)
AR (1) AR088252A1 (enExample)
AU (1) AU2012320421B2 (enExample)
BR (1) BR112014008152A2 (enExample)
CA (1) CA2849856C (enExample)
DK (1) DK3508494T3 (enExample)
ES (1) ES2913825T3 (enExample)
IL (1) IL231859B (enExample)
IN (1) IN2014DN03419A (enExample)
PL (1) PL2764016T3 (enExample)
SG (2) SG10201602673PA (enExample)
TW (1) TWI560272B (enExample)
WO (1) WO2013050551A1 (enExample)

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AU2012320421B2 (en) * 2011-10-07 2017-03-02 Lonza Ltd Regulatable promoter
CN104195165A (zh) * 2014-09-01 2014-12-10 北京爱必信生物技术有限公司 包含葡萄糖启动子的载体、宿主菌以及重组牛源胰蛋白酶的制备方法
CN114365792A (zh) 2014-11-11 2022-04-19 克莱拉食品公司 用于生成卵清蛋白的方法和组合物
WO2017021541A1 (en) * 2015-08-05 2017-02-09 Lonza Ltd Promoter variants
KR102593407B1 (ko) 2016-03-02 2023-10-24 론자 리미티드 개선된 발효 공정
CN110088279A (zh) * 2016-12-15 2019-08-02 株式会社钟化 新型宿主细胞及使用了其的目标蛋白质的制造方法
US12404309B2 (en) 2018-02-12 2025-09-02 Lonza Ltd Host cell for producing a protein of interest
EP3536784A1 (en) 2018-03-05 2019-09-11 ACIB GmbH Host cell engineered for improved metabolite production
US11866714B2 (en) 2018-06-07 2024-01-09 Basf Se Promoter for yeast
DK3874047T4 (da) 2019-01-11 2025-02-03 Lonza Ag Karbonkilde-reguleret proteinproduktion i en rekombinant værtscelle
DK3690052T5 (da) * 2019-01-29 2024-08-26 Clariant Produkte Deutschland Gmbh Kimær promotor til anvendelse i metabolsk manipulation
WO2020200415A1 (en) 2019-04-01 2020-10-08 Lonza Ltd Mut- methylotrophic yeast
HUE064229T2 (hu) 2019-04-01 2024-02-28 Univ Wien Bodenkultur Mut-metilotróf élesztõ
WO2020200414A1 (en) 2019-04-01 2020-10-08 Lonza Ltd Protein production in mut-methylotrophic yeast
US12096784B2 (en) 2019-07-11 2024-09-24 Clara Foods Co. Protein compositions and consumable products thereof
ES3015627T3 (en) 2019-07-11 2025-05-06 Clara Foods Co Beverage composition comprising recombinant ovomucoid protein
US10927360B1 (en) 2019-08-07 2021-02-23 Clara Foods Co. Compositions comprising digestive enzymes
CN115698300A (zh) 2020-03-26 2023-02-03 阿斯克肋匹奥生物制药公司 佛司可林诱导型启动子和低氧诱导型启动子
EP4127185B1 (en) 2020-04-01 2025-06-04 Lonza Ltd. Helper factors for expressing proteins in yeast
WO2021209743A1 (en) 2020-04-15 2021-10-21 Synpromics Limited Forskolin-inducible promoters and hypoxia-inducible promoters
EP4222266A1 (en) 2020-09-30 2023-08-09 Lonza Ltd. Host cells overexpressing translational factors
CN117120618A (zh) 2021-02-12 2023-11-24 勃林格殷格翰 Rcv 两合公司 用于增加蛋白质分泌的信号肽
WO2024133538A1 (en) 2022-12-20 2024-06-27 Lonza Ltd Host cells with pat1 knockout for increased specific protein productivity
WO2025247966A1 (en) 2024-05-29 2025-12-04 Mybios Gmbh Process for protein production in methylotrophic yeast host cell.
WO2026027251A1 (en) 2024-08-01 2026-02-05 Boehringer Ingelheim Rcv Gmbh & Co Kg Signal peptides for increased protein secretion

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WO2006089329A2 (en) * 2005-02-23 2006-08-31 Technische Universität Graz Mutant aox 1 promoters

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Also Published As

Publication number Publication date
TWI560272B (en) 2016-12-01
BR112014008152A2 (pt) 2017-04-18
AU2012320421A1 (en) 2014-03-20
IL231859A0 (en) 2014-05-28
SG10201602673PA (en) 2016-05-30
US20190185866A1 (en) 2019-06-20
PL2764016T3 (pl) 2019-08-30
US20220259608A1 (en) 2022-08-18
CN113788884A (zh) 2021-12-14
WO2013050551A1 (en) 2013-04-11
CA2849856C (en) 2023-03-14
KR20140069112A (ko) 2014-06-09
US11976284B2 (en) 2024-05-07
US11401523B2 (en) 2022-08-02
ES2913825T3 (es) 2022-06-06
EP2764016B1 (en) 2019-03-13
EP3508494B1 (en) 2022-02-23
US10301634B2 (en) 2019-05-28
CN110055248A (zh) 2019-07-26
US20140242636A1 (en) 2014-08-28
CA2849856A1 (en) 2013-04-11
CN113788884B (zh) 2024-07-23
KR102128957B1 (ko) 2020-07-02
US20170037418A1 (en) 2017-02-09
IN2014DN03419A (enExample) 2015-05-22
US9512432B2 (en) 2016-12-06
CN103998460A (zh) 2014-08-20
KR20190025048A (ko) 2019-03-08
IL231859B (en) 2020-08-31
AR088252A1 (es) 2014-05-21
EP3508494A1 (en) 2019-07-10
DK3508494T3 (da) 2022-05-23
TW201317350A (zh) 2013-05-01
JP2014530016A (ja) 2014-11-17
EP2764016A1 (en) 2014-08-13
AU2012320421B2 (en) 2017-03-02
SG11201400811QA (en) 2014-08-28
JP6113736B2 (ja) 2017-04-12

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