KR101947424B1 - 그의 보조인자의 부존재하에서 응고활성을 갖는 인자 ｉｘ 변이체 및 출혈 질환을 치료하기 위한 그의 용도 - Google Patents
그의 보조인자의 부존재하에서 응고활성을 갖는 인자 ｉｘ 변이체 및 출혈 질환을 치료하기 위한 그의 용도 Download PDFInfo
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| EP08013561.9 | 2008-07-28 | ||
| EP08013561A EP2149603A1 (en) | 2008-07-28 | 2008-07-28 | Factor IX variants with clotting activity in absence of their cofactor and their use for treating bleeding disorders |
| PCT/EP2009/005465 WO2010012451A1 (en) | 2008-07-28 | 2009-07-28 | Factor ix variants with clotting activity in absence of their cofactor and their use for treating bleeding disorders |
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| KR1020117001765A Division KR101768896B1 (ko) | 2008-07-28 | 2009-07-28 | 그의 보조인자의 부존재하에서 응고활성을 갖는 인자 ｉｘ 변이체 및 출혈 질환을 치료하기 위한 그의 용도 |
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| KR20170096210A KR20170096210A (ko) | 2017-08-23 |
| KR101947424B1 true KR101947424B1 (ko) | 2019-02-13 |
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| KR1020117001765A Active KR101768896B1 (ko) | 2008-07-28 | 2009-07-28 | 그의 보조인자의 부존재하에서 응고활성을 갖는 인자 ｉｘ 변이체 및 출혈 질환을 치료하기 위한 그의 용도 |
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| KR1020117001765A Active KR101768896B1 (ko) | 2008-07-28 | 2009-07-28 | 그의 보조인자의 부존재하에서 응고활성을 갖는 인자 ｉｘ 변이체 및 출혈 질환을 치료하기 위한 그의 용도 |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| US9249405B2 (en) | 2008-09-15 | 2016-02-02 | Paolo Simioni | Factor IX polypeptide mutant, its uses and a method for its production |
| TWI595004B (zh) | 2010-11-03 | 2017-08-11 | 介控生化科技公司 | 經修飾之第九因子多胜肽及其用途 |
| RU2013142015A (ru) | 2011-03-02 | 2015-04-10 | Ново Нордиск А/С | Нацеливание факторов свертывания крови на рецептор tlt-1 на поверхности активированных тромбоцитов |
| US10656167B2 (en) | 2011-07-25 | 2020-05-19 | Bioverativ Therapeutics Inc. | Assays to monitor bleeding disorders |
| CN103173482A (zh) * | 2011-12-22 | 2013-06-26 | 武汉科技大学 | 野生型和突变体hFⅨ毕赤酵母表达载体及构建方法和应用 |
| EP2666782A1 (en) * | 2012-05-22 | 2013-11-27 | Imnate Sarl | Coagulation factor VIII with reduced immunogenicity. |
| WO2014070349A1 (en) * | 2012-10-29 | 2014-05-08 | Regents Of The University Of Minnesota | Factor ix variants |
| CN103060366A (zh) * | 2012-12-25 | 2013-04-24 | 武汉科技大学 | 人凝血因子ⅸ突变体毕赤酵母表达载体及构建方法和应用 |
| PL2956477T5 (pl) | 2013-02-15 | 2024-05-27 | Bioverativ Therapeutics Inc. | Zoptymalizowany gen czynnika viii |
| EP3418390A1 (en) * | 2013-05-14 | 2018-12-26 | Struszym S.L. | Test strips for determining coagulation factor activities |
| EP2881463A1 (en) | 2013-12-09 | 2015-06-10 | DRK-Blutspendedienst Baden-Württemberg-Hessen gGmbH | Factor IX variants with clotting activity in absence of their cofactor and/or with increased F.IX clotting activity and their use for treating bleeding disorders |
| WO2016004113A1 (en) | 2014-06-30 | 2016-01-07 | Biogen Ma Inc. | Optimized factor ix gene |
| GB201420139D0 (en) | 2014-11-12 | 2014-12-24 | Ucl Business Plc | Factor IX gene therapy |
| WO2017015619A1 (en) | 2015-07-23 | 2017-01-26 | The Regents Of The University Of California | Antibodies to coagulation factor xia and uses thereof |
| PT3411478T (pt) | 2016-02-01 | 2022-09-13 | Bioverativ Therapeutics Inc | Genes do fator viii otimizados |
| IL271957B2 (en) | 2017-07-10 | 2024-02-01 | Uniqure Ip Bv | Means and methods for AAV-based gene therapy |
| GB201813528D0 (en) | 2018-08-20 | 2018-10-03 | Ucl Business Plc | Factor IX encoding nucleotides |
| US10842885B2 (en) | 2018-08-20 | 2020-11-24 | Ucl Business Ltd | Factor IX encoding nucleotides |
| GB201817810D0 (en) * | 2018-10-31 | 2018-12-19 | Ucl Business Plc | Modified factor IX polypeptides |
| WO2020104480A1 (en) * | 2018-11-19 | 2020-05-28 | Uniqure Biopharma B.V. | Adeno-associated virus vectors for expressing fviii mimetics and uses thereof |
| KR20210141608A (ko) * | 2019-03-19 | 2021-11-23 | 체에스엘 베링 렝나우 아게 | 치료요법에서 인자 ix 변이체 및 이의 용도 |
| CN110684798A (zh) * | 2019-09-03 | 2020-01-14 | 深圳新诺微环生物科技有限公司 | 肌肉靶向的微环dna基因治疗 |
| WO2021067389A1 (en) | 2019-09-30 | 2021-04-08 | Bioverativ Therapeutics Inc. | Lentiviral vector formulations |
| US12173307B2 (en) | 2020-06-24 | 2024-12-24 | Bioverativ Therapeutics Inc. | Methods for the purification of viral vectors |
| CN114277057B (zh) * | 2021-07-09 | 2023-10-13 | 上海天泽云泰生物医药有限公司 | 用于治疗或预防b型血友病的重组腺相关病毒载体和方法 |
| WO2023077012A1 (en) | 2021-10-27 | 2023-05-04 | Regeneron Pharmaceuticals, Inc. | Compositions and methods for expressing factor ix for hemophilia b therapy |
| US20250242056A1 (en) | 2024-01-26 | 2025-07-31 | Regeneron Pharmaceuticals, Inc. | Methods and compositions for using plasma cell depleting agents and/or b cell depleting agents to suppress host anti-aav antibody response and enable aav transduction and re-dosing |
| WO2025184567A1 (en) | 2024-03-01 | 2025-09-04 | Regeneron Pharmaceuticals, Inc. | Methods and compositions for re-dosing aav using anti-cd40 antagonistic antibody to suppress host anti-aav antibody response |
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|---|---|---|---|---|
| US6458563B1 (en) | 1996-06-26 | 2002-10-01 | Emory University | Modified factor VIII |
| WO1999003496A1 (en) * | 1997-07-21 | 1999-01-28 | The University Of North Carolina At Chapel Hill | Factor ix antihemophilic factor with increased clotting activity |
| EP1282438B1 (en) | 2000-05-10 | 2005-08-03 | Novo Nordisk Health Care AG | Use of pharmaceutical composition comprising a factor viia and a factor xiii |
| CN100475959C (zh) * | 2000-09-13 | 2009-04-08 | 诺沃挪第克健康护理股份公司 | 人凝血因子vii变体 |
| AU2002226028A1 (en) | 2000-11-14 | 2002-05-27 | Board Of Regents, Unversity Of Texas Systems | Mutant human factor ix with an increased resistance to inhibition by heparin |
| US20060040856A1 (en) * | 2003-12-03 | 2006-02-23 | Neose Technologies, Inc. | Glycopegylated factor IX |
| MX2007001294A (es) * | 2004-08-17 | 2008-03-04 | Zlb Behring Gmbh | Polipeptidos modificados que dependen de vitamina k. |
| US8383388B2 (en) * | 2006-06-19 | 2013-02-26 | Catalyst Biosciences, Inc. | Modified coagulation factor IX polypeptides and use thereof for treatment |
| US7700734B2 (en) * | 2007-01-09 | 2010-04-20 | Shu-Wha Lin | Recombinant human factor IX and use thereof |
| AU2008209986B2 (en) * | 2007-02-01 | 2012-11-08 | Baxter Healthcare S.A. | FVIII-independent FIX-mutant proteins for hemophilia A treatment |
| EP2108045B1 (en) * | 2007-02-01 | 2013-12-11 | Baxter International Inc. | Improved fix-mutant proteins for hemophilia b treatment |
| DE102008034724A1 (de) * | 2008-07-25 | 2010-01-28 | Alexander Koslow | Verkugelungs- / Zerkleinerungsmaschine |
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2018
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| WO2010012451A1 (en) | 2010-02-04 |
| JP2011528913A (ja) | 2011-12-01 |
| AU2009275391A1 (en) | 2010-02-04 |
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| US20110217284A1 (en) | 2011-09-08 |
| CN102112608B (zh) | 2013-11-20 |
| KR101768896B1 (ko) | 2017-08-17 |
| EP3241899A1 (en) | 2017-11-08 |
| JP6029826B2 (ja) | 2016-11-24 |
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| EP2390323A3 (en) | 2012-01-11 |
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| CN102112608A (zh) | 2011-06-29 |
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| EP2767587A3 (en) | 2014-11-26 |
| EP3241899B1 (en) | 2019-08-21 |
| KR20110036071A (ko) | 2011-04-06 |
| US20190017039A1 (en) | 2019-01-17 |
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