KR101932973B1 - Composition for prevention and improvement of periodontal disease or periodontal disease - Google Patents

Abstract

The present invention relates to a composition for prevention and improvement of periodontal disease or periodontal disease. The composition for prevention and improvement of periodontal disease or periodontal disease according to one embodiment of the present invention may include inorganic powder selected from a group consisting of powder shungite, fine powder illite, fine powder zeolite, fine powder elvan, fine powder bentonite, fine powder diatomaceous earth, fine powder germanium, fine powder ocher, fine powder bare rock, fine powder jade and a mixture thereof. The composition for prevention and improvement of periodontal disease or periodontal disease according to the present invention exhibits antibacterial activity against noxious bacteria and activates the regeneration of the above-mentioned dental tissue or periodontal tissue, thereby exhibiting effects of preventing or improving periodontal disease or periodontal disease.

Description

Technical Field [0001] The present invention relates to a composition for prevention and improvement of periodontal disease, periodontal disease, periodontal disease, periodontal disease, periodontal disease,

The present invention relates to a composition for preventing or improving periodontal disease or periodontal disease. More particularly, the present invention relates to a method for preventing and improving periodontal disease, which can prevent and improve periodontal disease by promoting regeneration of dental tissue, ≪ / RTI >

The size is a soft connective tissue that fills the inside of the teeth and refers to a place where the nerve and blood vessels are abundantly distributed to the surface layer of the dentin. Lesions that occur in these dimensions are called dental diseases.

Causes of dental disease are very diverse, but most cases are caused by bacterial infections due to tooth decay, perforation, fractures, cracks, and infection into the inside of the tooth cavity through the periodontal pouch. It can also cause trauma, wear, tooth cracking, heat and friction from dental instruments during treatment. Dental saliva caused by bacterial infection can be extended to periapical disease and periodontal disease. When a dental disease occurs, it progresses in the order of size reduction, dental decay, and dental necrosis. In the case of dimensional necrosis, the entire periodontal tissue may disappear as the dimension is dying and the blood supply to the dimension is not at all, which may result in a periapical disease or an abnormality of the entire tooth.

For the treatment of dental and periapical diseases, a dural replicator and a root canal filler are used. In general, calcium hydroxide, MTA (Mineral Trioxide Aggregate) and Gutta-percha have been used. In the case of MTA, it has sealing power and biocompatible properties, which is effective for treatment. However, as a relatively dental treatment agent, a high cost problem occurs and discoloration causes aesthetic problems. In the case of geranium, it is a non-physiological treatment method which is cost-effective and fluid, but loses dimensional vitality. Presently, conservative treatment methods for treating dentin or dental disease have so far resulted in weakened teeth, fragility, and risk of reinfection.

On the other hand, periodontal disease refers to an inflammatory disease that occurs in the gingival tissue, periodontal ligament, or alveolar bone, which is a surrounding tissue that maintains teeth.

Gingivitis and periodontal disease are known to cause a discomfort that significantly deteriorates the quality of life, and it is difficult to maintain proper cleansing of the oral cavity, thereby causing plaque deposition, thereby causing dental caries and periodontal disease. In addition, in the presence of hypersensitivity, the plaque can not be controlled, and as a result, the periodontal disease progresses and the gingival recession increases, causing a vicious circle in which the hypersensitivity becomes worse. Therefore, the ultimate result of treating periodontal disease is to restore damaged connective tissue, cementum and alveolar bone. To do so, it is necessary not only to regenerate periodontal ligament supporting alveolar bone, but also to treat alveolar bone and cementum Playback is required.

Studies for developing a therapeutic agent capable of effectively treating the dentin-dental disease and / or periodontal disease have been actively conducted. For example, Korean Patent Laid-Open No. 10-2012-0089547 (published on Aug. 13, 2012) discloses a method for producing a hard tissue including an enamel cell, an epithelial cell or a culture thereof as an active ingredient, And Korean Unexamined Patent Publication No. 10-2009-0033643 (published on April 6, 2009) discloses a tooth stem cell derived from a new periodontal ligament and a method for culturing the same. Korean Patent Laid-Open Publication No. 10-2016-0105627 (published on September 7, 2016) discloses a composition for treating periodontal disease including an enamel cell culture.

There is a need for a composition capable of preventing or ameliorating periodontal disease by enhancing regeneration activity of the above-mentioned dental tissue or periodontal tissue. Particularly, the composition for preventing or ameliorating a dental disease or a dental disease as described above has a problem that, when a synthetic medicine is used, irritation may occur or cytotoxicity may occur, so that side effects are generally accompanied when it is used for a long period of time. In addition, the cell culture method has a problem in that it is difficult to apply to a variety of daily necessities such as oral care products and toothpaste.

Therefore, it is necessary to develop a composition which can be easily mixed with food or oral care products without using side effects due to long-term use by using a composition based on natural materials.

KR 10-2012-0089547 A KR 10-2009-0033643 A KR 10-2016-0105627 A

It is an object of the present invention to provide a composition for regenerating a size by promoting regeneration of a dental tissue including dentin.

The present invention is to provide a composition for regenerating periodontal tissue that can promote regeneration of periodontal tissue.

The present invention relates to a composition for prevention and improvement of periodontal disease or periodontal disease, which is capable of preventing or improving periodontal disease or periodontal disease by activating regeneration of the above-mentioned dental tissue or periodontal tissue, will be.

It is another object of the present invention to provide a method for preparing the composition for preventing or ameliorating periodontal disease or periodontal disease.

In order to achieve the above object, according to one embodiment of the present invention, there is provided a composition for prevention or improvement of periodontal disease or periodontal disease, which comprises at least one selected from the group consisting of a fine powder such as shungite, fine powder illite, zeolite, An inorganic powder selected from the group consisting of bentonite, fine powder of diatomaceous earth, fine powder of germanium, fine powder of loess, fine powder of dolomite, fine powder of jade and mixture thereof.

The inorganic powder may have an average particle diameter of 0.0005 to 30 mu m.

The composition for preventing or improving periodontal disease or periodontal disease may further comprise a first plant extract selected from the group consisting of apricot tree extract, plum tree extract, cotton extract, and dandelion extract.

The composition for prevention or improvement of periodontal disease or periodontal disease may further comprise a second plant extract selected from the group consisting of almond extract, ganghyeol extract and mixtures thereof.

According to another embodiment of the present invention, there is provided a method for preparing a composition for preventing or ameliorating periodontal disease, comprising the steps of: preparing a composition for preventing or ameliorating periodontal disease or a periodontal disease, A dispersion-mixing step of producing a water-dispersed inorganic material for mixing and dispersing an inorganic powder selected from the group consisting of plagioclase, fine powdered jade and a mixture thereof in purified water; and

And a second plant extract mixing step of mixing the water-dispersed inorganic material with the second plant extract selected from the group consisting of a flower extract, a gangrene extract, and a mixture thereof after the dispersion and mixing step.

Hereinafter, the present invention will be described in more detail.

The composition for preventing or ameliorating periodontal disease or periodontal disease according to an embodiment of the present invention may contain at least one selected from the group consisting of a fine powder such as a shungite, a fine powder illite, a fine powder zeolite, a fine powdered bentonite, a fine powder bentonite, a fine powdered diatomaceous earth, , An inorganic powder selected from the group consisting of a fine powder, a yellow powder, a fine powder, a fine powder jade and a mixture thereof.

The term " fine powder " in the present invention refers to a powder produced by crushing with a ball mill, a jet mill or other grinding apparatus or having a property of a fine powder in the course of synthesis, and the fine powder is defined as having an average particle diameter of 100 m or less.

In the present invention,? Gite is a layer (thickness of 2 m or less) or a lens-like body in a low-denuded shale rich in small graphite microcrystals in the Proterozoic Jatulian in Shunga near Suoj? Rvi in northern Karelia Ladoga, do. It is black like pitch, dense, opaque, metallic luster. It is cold. Hardness 2.5. d 1.75 ~ 1.80, making a thick acid in a thick nitric acid that does not melt in the fire.

In the present invention, the chemical formula is (K, H 3 O) Al 2 (Si, Al) 4 O 10 (H 2 O, OH) 2. In terms of chemical composition, it is close to muscovite but relatively SiO2, MgO, H2O, and K2O are small. It is a kind of minerals such as dolomite. A hardness of 1 to 2, and a specific gravity of 2.6 to 2.9. The cleavage is complete with [001], streaking color is white, and earthy shine. There is an opinion that it is a mixed mineral containing different components, not an independent mineral in terms of chemical composition or crystal structure. It is produced in aluminum-rich heterogeneous or tuffaceous sedimentary rocks and is produced as altered minerals in hydrothermal ore deposits.

The zeolite referred to in the present invention is also referred to as zeolite. There are many kinds, but they have commonality in the points of high water content, crystal properties, and acidity. The hardness does not exceed 6, and the specific gravity is about 2.2. It is usually colorless or translucent white. This name was attached because it boils when it heats up by the hull. Most types are dissolved in hydrochloric acid and often become glue, but a few kinds do not dissolve in hydrochloric acid. The main types are antipodes, eye glasses, chabazite, soda ash, heulandite, stilbite, romantite, and enesite. It is produced in the cavities and bases of basic igneous rocks such as basalt and tuff tuff, and sometimes exists as a secondary mineral in granite and gneiss. It may also be produced from gold ore or other veins. Crystalline structure of each atom is loosened, so that even if the water filling the space is discharged as a high heat, the skeleton remains, so other fine particles can be adsorbed. This property is used as an adsorbent, and it is used as a molecular sieve (molecular sieve) for separating fine particles of different sizes.

The elvan in this invention is known as the term used in Oriental medicine in China and belongs to the granite class by geological classification. Quartz porphyry, feldspar porphyry, granite porphyry are similar to quartz-mononite in rock names. Quartz and feldspar are closely packed. It was named Mowanstone because it was like a rice ball made of barley rice, in which white, light yellow brown, light gray, dark green, or light green rocks were mixed with red or white dots. Its main components are anhydrous silicic acid and aluminum oxide, and contains a small amount of iron oxide. Known as the predominantly white, elbow-like stone, it used to be used as an anti-inflammatory agent to treat skin diseases such as swelling or swelling, which had previously been used to purify pills. According to Dong-bok, the nature is sweet, warm, and poisonous. It consists of 3 to 150,000 holes per cm3, which is strongly adsorbed and contains about 25,000 inorganic salts. It is also used as a harmful metal removing agent because it acts to exchange ions with heavy metals. It is known that when heat is applied to this rock, far-infrared rays are emitted. Because of these characteristics, it is used in various industries such as steam room, tableware, medical equipment.

In the present invention, many benzonites include quartz, feldspar, zeolite, and the like. The colors are white, gray, light brown, pale green, and the like. It has a pearly luster and a brass luster. It is produced as dense mass with fat. It is similar to montmorillonite in that it absorbs water and swells, and has a clear cation exchange property. Tuff and vitreous rhyolite have been altered. It is widely used as a main component of petroleum refining mud water, a binder of casting type, a mixing agent of ceramic raw material, and a base material of ointment. The name comes from the stratum of the Wyoming State, a discovery site.

The diatomaceous earth referred to in the present invention is mainly composed of silicic acid (SiO2) and is white or grayish white. It is light and soft enough to touch the powder with the finger. Since it is a minute porous material, it is highly absorbent and is a poor conductor of heat. The diatomaceous earth in our country is produced in soil form in the third or fourth strata. During the third phase of Koze III (Korea), fault movements in the direction of Northeast to North-North East occurred and several sedimentary basins were formed. Yeongil Basin, Gilju and Myeongcheon Gap, Gap between Seoul and Wonsan, and Tumen River basin were formed, and the third basement was deposited here. When deposits were formed, diatomaceous deposits were formed in small shallow lakes or freshwater basins, forming deposits. Among these sedimentary basins, diatomite in Yeongil Bay is the largest in diatomite deposits, and is concentrated in Wolsong and Yeongil in Gyeongsangbuk-do. In North Korea, there are also other areas in North Korea such as Hwanghyeon, Munsan-myeon, Ansan-myeon, Hamgyung-myeon, Anbyeon, Hamgyungbuk-do, Gyeongseong-gun, Nambyeon, Pyeonggang County, Cheonggyeongsaemyeo and is known as the origin of the cell. The development of diatomite as an ore in our country began in 1941 when it was incorporated into designated mining minerals by the Korean Mining Ordinance. Since then, domestic diatomaceous earth deposits have been found in various parts of the country. In particular, diatomaceous earth, which was produced in Yilli in Yangbuk-myeon, Wolsong-gun, Gyeongsangbuk-do, was used as a raw material and was used extensively in the production of Asahi Furnace in Japan. Recently, it has been used as a refractory material (refractory material) and because of its strong absorbency, it is mostly used as a filtering material for purification of industrial water, water, medicine, foods and the like. It is also used as a filler for plastics and paper, as an adsorbent for dynamite, as a hemostatic agent, as a mixture of cement.

In the present invention, germanium has an elemental symbol Ge, atomic number 32, and atomic weight of 72.59 ± 3. In 1871 D. I. Mendeleev discovered its existence and was called eicosil, but in 86 CE was discovered in Germany by C. A. Binkler, a German chemist named "Germania", which was discovered in Germanium (Ag GeS). Since it is similar to silicon, it is widely replaced by silicon of silicate in the crust. There are very few minerals mainly containing germanium although it is contained in sulfide minerals or coal containing copper or zinc.

The elvan stone referred to in the present invention is also referred to as a lavender. The chemical composition is KAl3 (SO4) 2 (OH) 6. It appears as a hexagonal plate or scaly crystal, usually in a massive or granular form. A hardness of 3.5 to 4, and a specific gravity of 2.6 to 2.9. The crystal type has a complete cleavage on the underside, and the cleavage surface has a pearly luster. Massive ones are not glossy. It is white, gray and occasionally red, yellow, and reddish brown. The streak color is white. It does not dissolve in hydrochloric acid but dissolves in potassium hydroxide or hot sulfuric acid. It is produced in the volcanic rock area subjected to hydrothermal alteration.

In the present invention, oxiran means dense and hard, transparent, beautifully shined, polished and glossy. Mineralogically, nephrite is a kind of amphibole, and jadeite is a type of alkali pyroxene. Nephrite are many milky white, green, yellow, red, and jadeite are green and white. There are various names depending on the color, but Baekok and Jade are representative. Since ancient times, it has been regarded as a precious stone in the Orient, and has been used as an ornamental stone and jade pot. Nephrite is produced as a vein in crystalline schist or gneiss in Turkey and in the contact zone of granite in northeast China. In Myanmar, jadeite is produced in the form of a veil of serpentinite, and is also produced in Yunnan or Tibetan plateau in China. The narrow meaning jade refers to jade, but the present invention is not limited thereto, and the jade in the present invention is defined to include all of the jade in the above-mentioned broad sense.

The inorganic powder may have an average particle diameter of 0.0005 to 30 mu m.

In general, inorganic powder or other fine powder particles used for oral care such as toothpaste are used for polishing a tooth surface to remove a plaque film or a bacterial film formed on a tooth surface. However, the inorganic powder used in the present invention is for promoting the regeneration of the dental tissue or periodontal tissue and is not for polishing the tooth surface. Particularly in the case of polishing the tooth surface, it is general to use a powder having a particle size much larger than the average particle size of the inorganic powder of the present invention. However, the present invention is intended to increase the regeneration activity by stimulating the cell tissue, so that it is limited to a size much smaller than the particles for polishing.

When the average particle diameter of the inorganic powder is less than 0.0005 占 퐉, the inorganic powders are irregularly aggregated again so that the dispersing ability is lowered, and the effect of cleaning by the interaction of the inorganic sites and the effect of stimulating the cells of the periodontal tissue there is a problem. On the other hand, when the average particle size of the inorganic powder is more than 30 mu m, since the particle size is relatively large, there is no effect of stimulating the cell unit constituting the dental tissue or periodontal tissue. Therefore, There is a problem that the regeneration activity for periodontal tissue is lowered.

Preferably the inorganic powder is the strontium ion (Sr ^{2 +),} calcium ions (Ca ^{2 +),} magnesium ions (Mg ^{2 +)} is, and the solution was mixed with heat-treated contains a mixture thereof at least one selected from the group consisting of the Lt; / RTI >

When the inorganic powder is mixed with the ion-containing solution and heat-treated, the inorganic powder stimulates the oral tissue or periodontal tissue in the cell unit to enhance the cell differentiation activity, thereby enhancing the regeneration effect of the dental tissue or periodontal tissue . In addition, since the inorganic powder itself has high washing power, the prevention or improvement effect on the dental disease or periodontal disease can be enhanced.

More preferably, the inorganic powder may be heat-treated by mixing with a solution containing strontium ions (Sr ^{2 +} ) and calcium ions (Ca ^{2 +} ). By the above range, the regenerating activity of the dental tissue or the periodontal tissue cell can be greatly enhanced, and the effect of improving the dental disease or periodontal disease caused by the antimicrobial force is enhanced.

More preferably, the inorganic powder comprises fine powder zeolite, and 20 to 60 parts by weight of a fine powdered water-swell gum, 20 to 60 parts by weight of fine powder, 20 to 60 parts by weight of fine powder bentonite 50 to 100 parts by weight of fine powdery diatomaceous earth and 10 to 30 parts by weight of fine powdered germanium and mixed with a solution containing strontium ions (Sr2 +) and calcium ions (Ca2 +) and heat-treated.

In the above range, the antibacterial activity is greatly increased by more than a simple combination due to the interaction of the powder constituting the inorganic powder, so that the activity of removing the bacterial membrane and the harmful bacteria in the oral cavity can be enhanced, Stimulation in the unit can further improve the regeneration effect of the dental tissue or periodontal tissue.

The composition for preventing or improving periodontal disease or periodontal disease may further comprise a first plant extract selected from the group consisting of apricot tree extract, plum tree extract, cotton extract, and dandelion extract.

Preferably, the first plant extract comprises 30 to 80 parts by weight of a plum tree, 30 to 80 parts by weight of a cottonwood extract, and 1 to 5 parts by weight of a dandelion extract, based on 100 parts by weight of the apricot extract, .

By the above-mentioned range, the extracts exhibit a higher antibacterial activity than the simple mixture due to the interaction of the extracts, and the effect of promoting the regeneration activity of the dental tissue or periodontal tissue can be doubled.

Preferably, in the composition for preventing or improving periodontal disease or periodontal disease, the first plant extract may be one adsorbed on the inorganic powder.

In particular, when the inorganic powder is impregnated with the first plant extract and adsorbed thereon, the anti-inflammatory activity and the antibacterial activity and the resistance against the harmful bacteria are increased by the use of the first plant extract.

The composition for prevention or improvement of periodontal disease or periodontal disease may further comprise a second plant extract selected from the group consisting of almond extract, ganghyeol extract and mixtures thereof.

Trapa japonica in the present invention grows in a pond or a marsh. The roots are embedded in the mud and the stem grows long and floats on the water. Leaves appear to be united and thick on the petiole, allowing it to float on the water as an air pocket. The leaf is triangular with a rhomboidal shape and has serrate. Feathery roots fall from the nodes of the main stream in the water. In July or August, white or slightly reddish flower blooms on the axil, with a diameter of about 1cm and four petals. The figurines are short and upward, but they bend downward as the fruit grows and are 2 to 4 cm long. Calyx leaf has hair, 4 stamens and 1 pistil. The fruit is rigid and inverted triangular with a thorn with calyx pieces on both ends and a central part being prominent.

The stiffness referred to in the present invention is also referred to as Kanghor. It grows in valley valley. It stands straight up to about 2m in height and branches at the top. Leaves are alternate phyllotaxis with petiole, and three small leaves are split into two flags. The small leaf is broad oval or ovate with pointed end and deep sawtooth on the edge. The petiole is shortened as it goes up, and the lower part of the petiole becomes broadened and becomes a sheath. In August or September, a white flower blooms on the end of a branch and at the end of a main stem in a double-layered inflorescence. It is divided into 10 to 30 small peduncles and has many flowers. There are one or two gun guns and six gun guns. Fruits are ripened in October and are elliptical with wings. It is fragrant and eats young seeds as herbs.

When the second plant extract is further contained, the anti-inflammatory activity is improved and the antibacterial effect is further improved against the composition for preventing or ameliorating periodontal disease or periodontal disease. In addition, Can be continuously removed.

Preferably, the second plant extract comprises a dried extract, and 20 to 60 parts by weight of the extract may be added to 100 parts by weight of the dried extract. By the above-mentioned range, the anti-inflammatory activity and the antibacterial activity are enhanced by the synergistic effect due to the interaction, and the persistence is increased.

According to another embodiment of the present invention, there is provided a method for preparing a composition for preventing or ameliorating periodontal disease, comprising the steps of: preparing a composition for preventing or ameliorating periodontal disease or a periodontal disease, A dispersion-mixing step of producing a water-dispersed inorganic material for mixing and dispersing an inorganic powder selected from the group consisting of plagioclase, fine powdered jade and a mixture thereof in purified water; and

And a second plant extract mixing step of mixing the water-dispersed inorganic material with the second plant extract selected from the group consisting of a flower extract, a gangrene extract, and a mixture thereof after the dispersion and mixing step.

The method for preparing a composition for preventing or improving periodontal disease or periodontal disease may further include a heat treatment step of applying heat treatment to the water-dispersed inorganic material after the dispersion and mixing step.

When the heat treatment step with the inorganic material is performed, the regenerating activity of the dental tissue or the periodontal tissue can be enhanced by stimulating the tissue.

The heat treatment step, the inorganic powders are mixed and contained strontium ion (Sr ^{2 +),} calcium ions (Ca ^{2 +),} magnesium ions (Mg ^{2 +)} a and at least one selected from the group consisting of a mixture thereof the solution It may be heat treated.

In addition, the strontium ion (Sr ^{2 +),} calcium ions (Ca ^{2 +),} magnesium ions (Mg ^{2 +)} is, and the manufacturing method of containing a mixture thereof at least one selected from the group consisting of a solution is conventional in the art It may be manufactured by a method that can be used by a knowledgeable person.

Preferably, the method for preparing a composition for prevention or improvement of periodontal disease or periodontal disease comprises a fine powder zeolite, wherein 20 to 60 parts by weight of a fine powder of shungite, 20 to 60 parts by weight of a fine powder is added to 100 parts by weight of the zeolite, parts by weight of fine powder of 20 to 60 parts by weight of bentonite, diatomaceous earth powder 50 to 100 parts by weight of germanium powder 10 to 30 parts by weight of the inorganic powder include strontium ion (Sr ^{+ 2),} and calcium ion solution containing the (Ca ²⁺⁾ An ion-treating step of mixing and dispersing

A heat treatment step of applying a heat treatment to the dispersion of the inorganic material that has undergone the ion treatment step after the dispersion and mixing step;

And 100 parts by weight of the above-mentioned apricot tree extract,

30 to 80 parts by weight of wood, 30 to 80 parts by weight of cotton tree extract, and 1 to 5 parts by weight of dandelion extract are mixed with a first plant extract mixing step.

More preferably, the method for preparing a composition for preventing or ameliorating periodontal disease or periodontal disease comprises the step of mixing a second plant extract selected from the group consisting of a rhizome extract, a gangrene extract and a mixture thereof after the first plant extract mixing step And may further comprise a plant extract blending step.

The composition prepared according to the method for the preparation of a composition for preventing or improving periodontal disease or periodontal disease has an antibacterial activity to remove the noxious bacteria in the oral cavity and inhibit the proliferation of the oral cavity, Thereby promoting prevention or improvement of dental disease or periodontal disease.

The composition for preventing or ameliorating periodontal disease or periodontal disease according to the present invention may be provided as a food composition. The food composition may include a food-acceptable food-aid additive in addition to the active ingredient. In addition, the composition for preventing or ameliorating periodontal disease or periodontal disease according to the present invention may be provided as a pharmaceutical composition. The pharmaceutical composition of the present invention may be in the form of tablets, pills, powders, granules, capsules, suspensions, solutions, emulsions, syrups, aerosols, sterilized injection solutions or the like in accordance with a conventional method for preventing and treating oral diseases Formulation is possible. Solid formulations for oral administration include tablets, pills, powders, granules, capsules, etc. These solid preparations are prepared by mixing at least one excipient, for example, starch, calcium carbonate, sucrose, lactose, . In addition to simple excipients, lubricants such as magnesium stearate and talc may also be used. Liquid preparations for oral administration include suspensions, solutions, emulsions, syrups and the like. In addition to water and liquid paraffin which are commonly used simple diluents, various excipients such as wetting agents, sweeteners, fragrances, Can be used. Formulations for parenteral administration may include sterilized aqueous solutions, non-aqueous solutions, suspensions, emulsions, freeze-dried preparations, suppositories, and the like. Examples of the non-aqueous solvent and the suspending agent include vegetable oils such as propylene glycol, polyethylene glycol and olive oil, injectable esters such as ethyl oleate, and the like. In addition, the pharmaceutical composition of the present invention may further comprise a carrier, an excipient or a diluent. Examples of the carrier, excipient or diluent include lactose, textol, sucrose, sorbitol, mannitol, xylitol, erythritol, maltitol, starch, acacia rubber, alginate, gelatin, calcium phosphate, calcium silicate, cellulose, methylcellulose, Mineral oil such as propyl methylcellulose, microcrystalline cellulose, polyvinylpyrrolidone, water, methylhydroxybenzoate, propylhydroxybenzoate, propylhydroxybenzoate, talc, magnesium stearate and silicon dioxide can be used have. The specific dosage of the pharmaceutical composition according to the present invention depends on factors such as the formulation method, the patient's condition and body weight, the patient's sex, age, degree of disease, drug type, administration route and period, excretion rate, May be variously selected by those skilled in the art, and the dosage and the number of times do not limit the scope of the present invention in any way. The pharmaceutical composition of the present invention can be administered to mammals such as rats, mice, livestock, humans, and the like through various routes. All modes of administration may be expected and may be administered, for example, by oral, intravenous, intramuscular or subcutaneous injection. The composition for preventing or ameliorating periodontal disease or periodontal disease according to the present invention may be provided as a quasi-drug composition. The quasi-drug composition of the present invention may include quasi-drugs for oral use. The components contained in the quasi-drug composition of the present invention may contain, as an active ingredient, the components commonly used in oral quasi-drug compositions in addition to the above-mentioned effective ingredients, and examples thereof include abrasives, wetting agents, binders, foaming agents, sweeteners, preservatives, A coloring agent, a solvent, a brightener, a solubilizing agent or a pH adjusting agent. The oral quasi-drug composition of the present invention may be prepared in any form conventionally produced in the art, and examples thereof include toothpaste, mouthwash, mouthwash, gum, candy, oral spray, oral ointment, , Mouthwash and gum massage cream, but are not limited thereto.

The composition for prevention and improvement of periodontal disease or periodontal disease according to the present invention promotes the regeneration of the dental tissue including dentin, thereby enhancing the dimensional regeneration effect.

The composition for preventing or ameliorating periodontal disease or periodontal disease according to the present invention can improve the regeneration effect of periodontal tissue by promoting regeneration of periodontal tissue.

The composition for preventing or ameliorating periodontal disease or periodontal disease according to the present invention exhibits an antimicrobial activity against harmful bacteria as well as a prophylactic and ameliorating effect of dental disease or periodontal disease by activating regeneration of the above-mentioned dental tissue or periodontal tissue.

The present invention provides a method for producing a composition for preventing or ameliorating periodontal disease or periodontal disease.

Hereinafter, embodiments of the present invention will be described in detail so that those skilled in the art can easily carry out the present invention. The present invention may, however, be embodied in many different forms and should not be construed as limited to the embodiments set forth herein.

1. Manufacture of inorganic powder particle size

As shown in the following [Table 1], the same powders were mixed in the same mass as the powders of fine powder, fine powder, fine powder, zeolite, fine powder of elvan, fine powder bentonite, fine powder of germanium, fine powder of germanium, (B) dissolving in purified water (NaCl 1wt%) mixed with salt for 30 minutes in consideration of the formulation of the oral care product or the use environment thereof, and dispersing the mixture for 1 minute or more using a homogenizer The acidity was evaluated.

Example Average particle size (μm) S1 0.005 S2 0.01 S3 1.23 S4 5.03 S5 9.41 S6 30.1 S7 51.7

2. Evaluation of water-dispersibility of inorganic powders

The water dispersibility of the inorganic powders prepared in accordance with the following Table 1 was evaluated to evaluate the degree of persistence of dispersibility. As a result, the dispersibility and the sustainability were shown in Table 2. The dispersibility was evaluated by an index of 1 to 10, and the higher the number is, the better the dispersibility and dispersion persistence.

Example Dispersibility and dispersion persistence S1 2 S2 7 S3 8 S4 8 S5 4 S6 3 S7 One

Referring to Table 2, it can be seen that the degree of dispersibility and the persistence thereof are the most excellent according to S2 to S4. It was confirmed that the inorganic powder can exhibit excellent dispersion and persistence as an aqueous dispersion agent when the average particle diameter is maintained at 0.01 to 5 탆.

And can be easily mixed by the particle size, and can exhibit uniform dispersion and dispersion retention for a considerable time. Therefore, it is easy to apply to various formulations because it is possible to maintain a high dispersibility and dispersibility without additional additives. In addition, it is evenly dispersible and its antibacterial and anti-inflammatory activity can be evenly distributed throughout the oral cavity.

3. Preparation of inorganic powder dispersion of mixed state

In order to ascertain the synergistic effect of the mixture of the fine powder and the grit, the fine powder, the fine powder, the fine powder, the zeolite, the fine powder, the bentonite, the fine powder, Inorganic powder was prepared as shown in Table 3. On the other hand, the average particle size of the above-mentioned fine powders, fine powders, fine powder zeolites, fine powder compacts, fine powder bentonites, fine powdered diatomaceous earths, fine powdered germanium, fine powdered yellow loam, In addition, the inorganic powder was prepared by mixing then mixed in with the strontium ion (Sr ^{2 +)} and calcium ions (Ca ²⁺⁾ solution and heat-treated for 1 hour, purified water.

On the other hand, when the inorganic powder is not subjected to ion treatment so that it can be compared with T1, it is preferable that the inorganic powder is not treated with the same amount of fine powder, grit, fine powder, light powder, fine powder zeolite, fine powder bentonite, fine powder bentonite, fine powder diatomaceous earth, fine powder germanium, By weight to prepare TX.

T1 T2 T3 T4 T5 T6 T7 T8 T9 Zeolite 100 100 100 100 100 100 100 100 100 ? Gait 100 30 30 30 10 20 40 60 80 Elven stone 100 - 30 30 10 20 40 60 80 Bentonite 100 - - 30 10 20 40 60 80 Diatomaceous earth 100 - - - 30 50 75 100 125 germanium 100 - - - 5 10 20 30 40

(Unit: parts by weight)

4. Antimicrobial and antimicrobial activity evaluation of inorganic powder dispersion of mixed nature

In order to evaluate the antimicrobial activity against the inorganic powder dispersion of the mixed property, denture was used to evaluate the antibacterial activity against S. mutans and plaque removal ability. The anti-inflammatory activity was also evaluated.

Specifically, the denture was soaked for 4 hours using a plaque colorant as a plagging agent, and the coloring area of the post-cleaning denture with respect to the surface area of the pre-cleaning denture using the above T1 to T9 was compared with ( ) / Washing area). The detergency was tested, and the degree of odor and flavor after denture washing was evaluated as an index of 1 to 10, with T1 as the standard (exponent 1) and comparing T2 to T9. The higher the index number, the better the effect. The panel was composed of 20 denture users and 20 dentists.

In order to investigate the antimicrobial activity against S. mutans, T1 to T9 were added to BHI liquid medium (Brain-Heart Infusion broth: 3.7%), and S. mutans was inoculated to maintain the temperature at 35 to 37 , And the effect on the S. mutans growth inhibition was measured after culturing in a thermostat for 24 hours. The inhibitory effect was expressed as% compared with the control group to which T1 to T9 were not added, and the lower the value, the better the effect.

To assess the effects of anti-inflammatory activity on changes in interleukin-1 (IL-1) and tumor necrosis factor (TNF-α) levels associated with inflammation and connective tissue destruction of periodontal ligament, human-derived THP-1 After incubation in RPMI 1640 medium supplemented with 10% FBS, the cell line was treated with Lipopolysaccharide (LPS), which is an inflammation inducing substance, and each extract according to the present invention, and then TNF- alpha secretion was measured by enzyme immunoassay (ELISA). Perfume activity was determined by measuring the activity of purified water as Conrtol. The results are shown in Table 4 below.

T1 T2 T3 T4 T5 T6 T7 T8 T9 TX Cleaning power One One One One One 3 3 4 One 7 Antimicrobial 98 111 108 98 89 66 68 63 88 174 Salt salt activity O O O O O O O O O X

(Unit: index,%)

Referring to Table 4, it can be seen that the cleaning effect is excellent due to the synergistic effect due to the interaction in the range from T6 to T8. However, it can be seen that there is no effect due to mutual combination of the inorganic materials. On the other hand, it was confirmed that the effect of inhibiting the activity of S. mutans in T5 to T9 was confirmed, and that the effect of T6 to T8 was remarkably excellent. On the other hand, TX showed no anti-inflammatory activity.

Therefore, according to the present invention, it is estimated that the harmful bacteria can be effectively removed from the dental tissues through the antibacterial activity and anti-inflammatory activity, and thus the regenerative activity of the dental tissue can be maintained. Therefore, it can have a considerable effect on prevention or improvement of dental disease.

4. Mixed  For the inorganic powder dispersion Of periodontal stem cells  Damage recovery ability test

In order to confirm the effect of the inorganic powder dispersion on stimulation of periodontal tissue stimulation of regeneration of periodontal tissue, a scratch damage analysis model was used to determine the migration of stem cells and the ability to transfer to damaged tissue . The test results were evaluated as percent recovery after 24 hours, and% recovery in Conrtol using purified water. The results are shown in Table 5 below.

Con T1 T2 T3 T4 T5 T6 T7 T8 T9 TX Promotes periodontal regeneration 24% 34% 37% 41% 38% 43% 67% 71% 77% 37% 23%

Referring to Table 5, it can be seen that the regenerating activity of the columnar cells is promoted compared with the control by T1 to T9. It can be seen that the ability to recover periodontal tissue is remarkably excellent, especially with T6 to T8. It is considered that this stimulates the periodontal tissue at the cell unit by the synergistic effect of the interaction in the above range, thereby enhancing the regeneration effect of the damaged tissue by making the transition ability of the periodontal tissue to the stem cell more improved. On the other hand, it was evaluated that TX showed regenerative activity of almost no difference from control.

Thus, according to the present invention, it can be seen that, in addition to the anti-inflammatory and antibacterial activity, the regenerating activity can be enhanced by stimulating the periodontal tissue directly at the cell unit. Thus, it is possible to prevent or improve periodontal disease.

6. The first plant extract-adsorbed inorganic powder dispersion

A plant extract constituted as shown in the following [Table 6] was prepared, The inorganic powder prepared according to T7 was mixed with the plant extract to adsorb the plant extract to the inorganic powder.

On the other hand, each of the following apricot tree extract, plum tree extract, cottonwood extract and dandelion extract was prepared by mixing and extracting each apricot tree, plum, cottonwood and dandelion with hot water.

C1 C2 C3 C4 C5 C6 C7 C8 C9 Apricot Tree Extract 100 100 100 100 100 100 100 100 100 Plum tree extract - 30 - - 20 30 50 80 100 Cottonwood extract - - 30 - 20 30 50 80 100 Dandelion extract - - - 30 0.5 One 3 5 7

(Unit: parts by weight)

7. Detergency test on inorganic powders containing the 1st plant extract

The plant extracts of C1 to C9 were adsorbed to T7 and dispersed in purified water to examine the washing power of each mixture. The test method was carried out in the same manner as in the cleaning power test for the inorganic powder dispersion of the mixed property, and the results are shown in Table 7 below.

C1 C2 C3 C4 C5 C6 C7 C8 C9 Cleaning power 3 4 5 4 3 7 6 7 3 Antimicrobial 73 68 59 62 65 46 54 55 70

(Unit: index,%)

Referring to Table 7, it can be seen that the cleaning power and the antibacterial activity are improved according to the plant extracts used in the case of C6 to C8. Therefore, when the plant extracts are mixed and used, a synergistic effect is exerted on the washing power and the antimicrobial force of the inorganic powder treated in the ionic solution. Especially, it was confirmed that the synergistic effects of the plant extracts from C6 to C8 are exhibited by the interaction.

8. Preparation of 2nd plant extract

The plant extract C7 was adsorbed on the inorganic powder T7 and then the second plant extract having the composition shown in the following Table 8 was mixed. The following acorn extracts and ganghyeol extracts were prepared by hot water extraction and filtration as in the case of the first plant extract.

D1 D2 D3 D4 D5 D6 Acorn extract 100 100 100 100 100 - Ganghyeong extract - 10 20 60 100 100

(Unit: parts by weight)

9. Detergency test on inorganic powders containing the second plant extract

The T7 adsorbed T7 was mixed with the plant extracts of D1 to D6, and the detergency was tested. The test method was carried out in the same manner as in the washing power test for the inorganic powder dispersion of the mixed property, and the results are shown in the following Table 9. [

D1 D2 D3 D4 D5 D6 Cleaning power 7 7 9 9 7 7 Antimicrobial 45 41 38 28 40 46

(Unit: parts by weight,%)

Referring to Table 9, it can be seen that when the second plant extract is included, the washing power and the antimicrobial power are generally increased. In particular, it can be seen that the cleaning activity and the antibacterial activity are increased by D3 and D4. It can be seen that the washing power and the antibacterial activity are further improved by the synergistic effect by the interaction in the combination range of D3 and D4.

The present invention can be manufactured in various formulations and is not limited to the above-described experimental examples. It can be manufactured as a variety of medicinal external preparations and oral care products, and can also be used as food or the like.

While the present invention has been particularly shown and described with reference to exemplary embodiments thereof, it is to be understood that the invention is not limited to the disclosed exemplary embodiments, Of the right.

Claims (5)

It is composed of fine powder, shungite, fine powder illite, fine powder zeolite, fine powder compactor, fine powder bentonite, fine powder diatomaceous earth, fine powder germanium, fine powder yellow loam, fine powder blast furnace, fine powder jade, ≪ RTI ID = 0.0 >
A composition for prevention and improvement of periodontal disease or periodontal disease. The method according to claim 1,
The inorganic powder has an average particle diameter of 0.0005 to 30 mu m
A composition for prevention and improvement of periodontal disease or periodontal disease. The method of claim 1, wherein
Further comprising a first plant extract selected from the group consisting of apricot tree extract, plum tree extract, cotton extract, and dandelion extract
A composition for prevention and improvement of periodontal disease or periodontal disease. The method of claim 3,
Further comprising a second plant extract selected from the group consisting of acorn extract, mandarin extract, and mixtures thereof
A composition for prevention and improvement of periodontal disease or periodontal disease. An inorganic powder selected from the group consisting of a powdered waterweed, a powdered fine powder, a powdered zeolite, a powdered zeolite, a powdered bentonite, a powdered diatomaceous earth, a powdered germanium, a powdered germanium, a powdered fine yellow powder, a powdered fine powder, A dispersion-mixing step of producing a water-dispersed inorganic material and
And a second plant extract mixing step of mixing the water-dispersed inorganic material with a second plant extract selected from the group consisting of a wilt extract, a gangrene extract, and a mixture thereof after the dispersion and mixing step
A method for the preparation of a composition for prevention and improvement of periodontal disease or periodontal disease.