CN104490608A - Multiple composition for oral treatment - Google Patents
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- CN104490608A CN104490608A CN201410826130.0A CN201410826130A CN104490608A CN 104490608 A CN104490608 A CN 104490608A CN 201410826130 A CN201410826130 A CN 201410826130A CN 104490608 A CN104490608 A CN 104490608A
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Abstract
The invention discloses a multiple composition for oral treatment. The multiple composition comprises 2-25 parts of bioglass and 0.1-10 parts of phosphate of potassium. The bioglass is spherical or ellipsoidal and the granularity is 220-2500 nanometers; the surface layer of bioglass is a mesoporous structure, wherein the mesoporous bore diameter is 6-45 nanometer; the bioglass comprises the components in form of oxides in parts by weight: 20-35 parts of CaO, 30-38 of SiO2, 0.1-1.8 parts of P2O5, 12-18 parts of B2O3, 0.1-0.8 part of CuO, 0-0.7 part of ZnO and 0-4 parts of Na2O, wherein the sum of CuO and ZnO accounts for 0.6-1.5% of the total weight and the ratio of the content of K2O and the sum of CuO and ZnO is (8-30): 1. The composition can be used for immediately reducing sensation, desensitizing with long action, protecting gum and stopping bleeding, inhibiting antibacterial activity of decayed teeth and whitening the teeth and has extreme promotional and practical values.
Description
Technical field
The invention belongs to oral care materials field, be specifically related to a kind of multiple oral treatment compositions.
Background technology
Sensitivity of tooth, is called for short tooth quick, refers to that the dentin exposed after gingiva is degenerated runs into acid, the of short duration and sharp-pointed pain perception produced when stimulating such as sweet, hot and cold.Tooth is quick is not diagnosed as dental defect and disease usually, and the pain that it produces brings inconvenience to patient, and may produce chronic or causalgia, even changes dietary habit, refuses cold, heat, acid, sweet irritable food such as grade.But the quick person of tooth is often occurred together some Chronic dental or pathological change of oral cavity, as dental caries, gingiva are degenerated the regular gingival hemorrhage etc. caused.
Comprise odontoblast's sensor theory about the main theory that tooth is quick, teleneuron directly accepts to stimulate theory and hydrodynamic theory.Current fluid dynamic theory is considered to the main mechanism of the quick generation of tooth, this theory belongs to permeability tissue based on dentinal tubule, tooth is quick is the result that liquid flows in dentinal tubule, dentin flow quantity is larger, and the abnormal flow of dentin liquid can cause Intradental nerve excited and produce the pain sensation.The direction that research in recent years and clinical treatment provide is, alleviate the therapy mechanism of dentine hypersensitivity to be to disturb to the neural reflex of pain stimulation or by blocking open dentinal tubule thus stoping hydrodynamics mechanism, thus effectively block dentinal tubule's mouth to dentine hypersensitivity fast and lasting remission.In essence, quick whether thoroughly elimination of tooth is that to be subject to the intensity of environmental stimuli by dental pulp sensory nerve closely related with frequency.Desirable desensitized state is: can rapid recovery or eliminate dental pulp sensory nerve and stand environmental stimuli, and chronicity can block outside stimulus and be delivered to the sensorineural passage of dental pulp again, this is clinical the best and ideal effect.It is the fundamental guiding ideology for the treatment of dentine hypersensitivity that open dentinal tubule's mouth is closed by the multiple desensitization technology developed so far, such as laser, fluoride, calcium phosphate, coating reparation etc.Nd:YAG laser irradiates the Organic substance degeneration that the heat effect produced in dentin surface can make dentin surface instantaneously, and the melting of apatite inorganic matter is closed dentinal tubule's mouth of exposure and reaches certain depth, reaching desensitization object.But this method is not enough to irradiating blind spot to the dentin exposed inside tooth body and between teeth space, and patient to the hospital admission being equipped with this kind equipment, must have inconvenience to middle-aged and elderly people more simultaneously.Secondly, block and cause the technical scheme of the neural reflex of pain stimulation to mainly contain to utilize artificial exploitation material to close its passage.Dentin bonding agent based on corrosiveness, as taken glutaraldehyde as its effective liquid protein degeneration of desensitizing in the desensitizer Neng Shishi dentinal tubule of composition, solidifying, with closed dentinal tubule, stop liquid in pipe flowing, good to the desensitization effect caused by sensitive necks of teeth and the wearing and tearing of light moderate, immediate effectiveness is remarkable.But because this desensitizer is corrosive to mucosa, must careful operation in therefore clinical, application is restricted.
Use short mineralising principle can be realized by the application of antiallergic sense toothpaste.Desensitizing toothpaste is easy to use because of it, just can prevent and treat dentine hypersensitivity in daily life, becomes the selection that most of patient treatment tooth is quick.At present, the desensitizing toothpaste overwhelming majority is that the single component of chemical desensitizer potassium nitrate, fluoride, stannide and strontium chloride or its mixture are (as Chinese patent, publication number CN1688281A, CN1306416A), also have tooth paste product (the such as Chinese patent of minority using Chinese medicine and western medicine extract as antiallergic sense functional component, publication number CN102579286A), the made toothpaste (Chinese patent of amphipathic organic material compositions, publication number CN1205627A), Folium Camelliae sinensis extract combined tooth-paste (Chinese patent, publication number CN130 8932A) etc.Potassium ion can make nerve fiber depolarization, reduces sensorineural sensitivity; Fluorion can improve the capacity antacid of tissue of tooth, suppresses dentin acid dissolve, reduces open tubules, thus promotes the remineralization of tooth; Calcium in strontium and dental hard tissue generates calcification saamite and is deposited on dentinal tubule's wall, reaches the therapeutic effect blocking dentinal tubule; Strontium chloride plays sedation-analgesia to dentin nerve and can accelerate the formation of secondary dentin simultaneously, therefore also can play the effect of analgesia desensitization.Desensitizing toothpaste desensitization effect is remarkable, but this mode is effective usually slower.Add in antiallergic sense toothpaste strontium chloride be first be used in toothpaste carry out dentinal tubule close composition, but the problem of strontium product salt not by causing natural calcium phosphorus precipitation to solve dentine hypersensitivity, its application is limited, gradually replace by potassium salt toothpaste.Antiallergic toothpaste comprises potassium salt to benumb the pain of dentine hypersensitivity, this kind of containing often also fluorine-containing in the toothpaste of potassium, plays anticaries action.Conventional has potassium oxalate, potassium nitrate, potassium chloride, potassium fluoride and potassium citrate.Wherein, the oxalic acid in potassium oxalate and the calcium in dentinal tubule react and form calcium oxalate crystal, and the permeability of dentinal tubule can be made significantly to reduce, and its effect can prolongation in time and increasing.But potassium oxalate has potential toxicity to have scholar's research to show, suggestion should limit its use clinically.And for example, add potassium nitrate, potassium chloride, potassium citrate in toothpaste and be used in antiallergic sense toothpaste multinational, this kind of desensitization activity composition, one day twice, the time of two weeks can reach significantly falls quick effect.The desensitization effect of a Colgate-Palmolive toothpaste containing arginine, calcium carbonate, fluoride of recent report is better than containing traditional desensitizing toothpastes such as potassium ions.Arginine is a kind of natural amino acid be present in saliva; arginine can facilitate calcium-microcosmic salt deposition; form the protective layer being rich in calcium; blocking and closed open dentinal tubule; the protective layer formed has erosion resisting to acid; block the generation of dentine hypersensitivity pain thus, but this Colgate-Palmolive specially imitates antiallergic Fluoride in Toothpaste content up to 1450 ppm, if bad bone metabolism can be caused to react because gulping down through constant error.
In recent years, people, according to the surperficial mineralization characteristic of the promotion artificial bone that the 45S5 bio-vitric of Hench teaching inventive is good, carry out the application of oral desensitizing aspect, with 45S5 bio-vitric CaO-SiO
2-P
2o
5-Na
2o quaternary oxide is main functional component, develops multiple desensitizing toothpaste brand or desensitizer, toothpaste (NovaMin as quick in Novartis
tM; Chinese patent 97193085.6) and the quick clear tooth desensitizers of Austria etc., be all utilize 45S5 bioglass particles as the composition that mainly desensitizes, carry out desensitization application.Over 2004, to be used in desensitizing toothpaste by the superfine glass granular materials utilizing this proportioning to form and to obtain successfully, thus having opened up desensitizing toothpaste novel form.Recently, a kind of strontium enhanced biological glass and top tooth cream brand (Chinese patent CN101407373A) healthy and full of vigor increases SrO, MgO, CaF, B on above-mentioned 45S5 bio-vitric basis
2o
3, K
2o component is formed; But part additive can early stage remineralization rates, anti-plaque is by CaF wherein simultaneously
2the F that components dissolved is separated out
-ion, needs life-time service just can reach certain effect.
Make a general survey of clinical practice in recent years, although a large amount of specially effect desensitizing toothpaste creates good effect to desensitization, but all can not solve and comprise the compound oral problem of multiple tooth pathological changes clinically, the dental plaque problem that dentine hypersensitivity patient association dental caries, gingival hemorrhage and bad habit cause, alleviate the quick problem of tooth based on the release calcium of routine, phosphonium ion remineralization bio-vitric, and the alkalescence anti-microbial property that standard biologic glass degraded release ion process causes is very faint.Short-term and long-acting working in coordination with can not be taken into account simultaneously, effectively solve the multiple oral problem occurred together.Therefore, there is multiple treatments-treatment and prevention and " namely imitate-long-acting " unified mutually to fall quick-desensitization material technology be the optimal path solving clinical problem.
Applicant proposed one namely to imitate and fall quick-long-acting desensitization solution, namely surface layer is used to have the bio-vitric of meso-hole structure and the phosphate compound of potassium, and utilize several functions assistant carrier, form the nursing materials that toothpaste type, chewing gum type, tooth body adhesive agent formula, collutory formula oral desensitizing and concomitant problem solve in the lump.The bio-vitric of applicant's design, add in turn to reach the fine adjustment that particulate matter forms from inside to outside by optimizing each material in sol-gel bio-vitric building-up process, and utilize the conventional conventional mesoporous template molecule of citric acid dispersant replacement to construct the dispersant of adjusting control agent and gelation process based particles as meso-hole structure, thus preparation form is more regular, granule forms the high bioactivity glass that there are differences with micro structure from inside to outside; Secondly, the phosphate of potassium is utilized to fall quick main functional component and the collaborative efficiency improved dentinal tubule's mineralising and close as namely imitating; Again, utilize the phosphate containing the potassium of different hydrogen amount can effectively regulate bio-vitric to degrade and discharge the regulator that inorganic ions process causes saliva of buccal cavity alkalization degree, reach the effect strengthening and suppress dental caries harmful bacteria activity.Therefore, the bio-vitric superfine particulate matter that the phosphate of potassium and surface layer have a meso-hole structure combine the generation that " bi-component-multi-functional " system of forming can be good antibacterial, protect gum and stop blooding, promote remineralization, alleviate dental pulp sensory nerve stimulation, close dentinal tubule and cover dental plaque and the Synergistic of the multiple efficacies of tooth-whitening aspect, this material has excellent biological safety and biocompatibility, is that process comprises and falls the quick-effective technology scheme of total mouth care problem that desensitizes.
Summary of the invention
The object of the invention is for the problems of the prior art, provide a kind of multiple oral treatment compositions, said composition can fall quick-long-acting desensitization in time, protects gum hemostasis, suppress caries bacteria activity and tooth-whitening.
The present invention is achieved through the following technical solutions:
A kind of multiple oral treatment compositions, the parts by weight of the component comprised and each component are:
Bio-vitric 2-25
The phosphate 0.1-10 of potassium
Spherical in shape or the elliposoidal of described bio-vitric, granularity is 220 ~ 2500 nanometers, and the surface layer of bio-vitric exists meso-hole structure, and mesoporous pore size is 6 ~ 45 nanometers, and the parts by weight that in bio-vitric, each component represents in the form of an oxide are:
CaO 20~35；
SiO
230~38；
P2O
50.1~1.8；
B
2O
312~18；
CuO 0.1~0.8；
ZnO 0~0.7；
Na
2O 0~4；
CuO and ZnO content sum account for 0.6% ~ 1.5%, K of total amount
2the ratio of the content of O and CuO and ZnO content sum is (8 ~ 30): 1;
The distribution of particle sizes of bio-vitric is: the particulate matter lower than 250 nanometers is no more than 5% of total amount; The particulate matter of 250 500 nanometer range is no more than 20% of total amount; The particulate matter of 500 2000 nanometer range is not less than 65% of total amount; The particulate matter being greater than 2000 nanometers is no more than 20% of total amount.
The phosphate of described potassium be in potassium phosphate, potassium hydrogen phosphate, potassium dihydrogen phosphate any one and more than.
Described multiple oral treatment compositions also comprises the auxiliary agent of following parts by weight:
Abrasivus 1-30;
Thickening adhesive 1-10;
Wetting agent 1 20;
Foaming agent 0.5 4.5.
Described abrasivus be in calcium carbonate granule thing, silicon oxide particle thing, aluminum hydroxide particles thing, dicalcium phosphate dehydrate, calcium phosphate dibasic anhydrous any one and more than.
Described wetting agent be Polyethylene Glycol, sorbitol, glycerol any one and more than.
Described foaming agent is dodecyl sodium sulfate; Described thickening adhesive is carboxymethyl cellulose.
Described multiple oral treatment compositions also comprises helper function vector and the moisture of 1 30 weight portions;
Described helper function vector be conducive to dispersion, painted, anticorrosion, increase taste, bonding, emulsifying, softening and antioxidative compound.
The preparation method of described bio-vitric is: a, nitric acid, ethyl orthosilicate, phosphate are dissolved in successively in deionized water, wherein the weight ratio of silicon, phosphorus with its oxide basis for P2O5:SiO2=3:(50 ~ 285), at room temperature stir 30-60 minute, for subsequent use;
B, boric acid, calcium salt, mantoquita, zinc salt, potassium salt, sodium salt, citric acid to be dissolved in the deionized water solution of step a successively completely, 10 ~ 30 minutes, adjacent two kinds of salt joining day intervals, wherein potassium is (10 ~ 25) with oxide basis and copper and zinc with the mass ratio of oxide basis sum: 1, at room temperature stir 10 ~ 30 minutes, for subsequent use;
C, in the solution of step b, add calcium salt, phosphate and citric acid, keep copper and zinc to be 0.8% ~ 1.2% of total oxide mass with oxide basis sum, and after fully stirring 10 ~ 45 minutes again, 35 ~ 60
ostill aging 24 ~ 72 hours of C, for subsequent use;
D, by the gel after c ageing 120 ~ 180
odrying 6 ~ 24 hours under C, then 580 ~ 750
ocalcine 60 ~ 180 minutes under C, obtain bio-vitric according to claim 1.
In the present invention, optimizational function assistant carrier and content thereof can build the oral care implement of various ways, playing the cooperative effect immediately falling quick-long-acting desensitization, protect gum hemostasis, suppress caries bacteria activity and tooth-whitening, can be toothpaste type, Chewing gum, the adhesion of tooth body dosage form, dosage form of gargling oral care implement.
There is not strict restriction in the present invention's inorganic mineral required to other human physiological metabolism.
The invention has the advantages that:
1, bioglass material ultra-fine grain has nanoscale to micron order yardstick, grain surface layer has meso-hole structure, calcium ion, phosphate anion, potassium ion, sodium ion, borate ion, silicate ion, zinc ion and/or copper ion can be discharged fast in salivary environment, and cause granule and the alkalization of saliva contacts district and quick mineralising sedimentary phosphor lime stone to close dentinal tubule;
2, the potassium ion of the phosphate stripping of potassium acts on dental pulp sensory nerve through dentinal tubule, reduces sensorineural sensitivity fast and reach to alleviate the quick effect of tooth (namely playing " namely effect is fallen quick " effect).
3, the phosphate anion of the phosphate stripping of potassium work in coordination with bio-vitric degraded release calcium, phosphate anion, be conducive to improving calcium in dentinal tubule, phosphonium ion degree of supersaturation and accelerate apatite mineralising deposition (namely shorten " long-acting desensitization " and cycle);
4, the phosphate of potassium has solubility property faster, according to the content of hydrogen, course of dissolution can make further fine adjustment to the salivary environment pH value of bio-vitric degraded release inorganic ions, the fluctuation being beneficial to pH value produces concertedness antibacterial anti-caries effect, and play accelerate oversaturated calcium, phosphonium ion dentinal tubule and bioglass particles surface deposition mineralising sedimentary phosphor lime stone effect (namely shorten " long-acting desensitization " cycle);
The high-ratio surface ultra-fine grain 5, with meso-hole structure can produce building-up effect to thrombin, realizes protecting gum hemostasis; Simultaneously, promoting that grain surface layer is comparatively fast degraded while the calcium ion of release induction apatite mineralising, phosphate anion, the copper of the release that occurs together, zinc, the isoionic compositions of boron to regulate blood capillary regeneration and suppress the activity of dental caries harmful bacteria, dental plaque activity produces remarkable result.
6, present composition preparation technology is simple, and the phosphate particle itself of bio-vitric and potassium and the multiple inorganic ions compositions of release have multiple Synergistic type biological effect feature.
Accompanying drawing explanation
Fig. 1 is the transmission electron microscope photo of many bio-vitrics pattern.
Detailed description of the invention
Below by exemplary embodiment, the present invention will be further elaborated, but these examples do not limit the scope of the invention, and the material of all technology realized based on foregoing of the present invention all belongs to protection scope of the present invention.Illustrate content of the present invention further below in conjunction with example (by preparation 10 g compositions), but these examples do not limit the scope of the invention, the compositions of all technology realized based on foregoing of the present invention all belongs to protection scope of the present invention.Compositions that embodiment uses, each component agent purity is all not less than its analytical reagent purity index.
embodiment 1
The desensitizing toothpaste of preparation containing bio-vitric-potassium dihydrogen phosphate two component, bio-vitric surface layer meso-hole structure layer thickness is 1/5th of particle radius, and the component (mass percent, %) of toothpaste is listed as follows:
15 % bioglass particles things
2% potassium dihydrogen phosphate
30% abrasivus-silicon oxide ball particulate matter
3% thickening agent-carboxymethyl cellulose
20% wetting agent-Polyethylene Glycol
2% foaming agent-dodecyl sodium sulfate
0.3% flavour enhancer-Mint Essence
0.1% antiseptic-potassium sorbate
All the other are moisture;
Wherein, in bio-vitric, the mass percentage of each component is:
CaO 28%
SiO
238%
P
2O
5 2%
B
2O
312%
CuO 0.5%
ZnO 0.3%
K
2O 16%
Na
2O 3.2%；
Wherein, the particle size distribution range of bio-vitric:
Lower than 250 nanometers is 3% of total amount
250 ~ 500 nanometer range be 12% of total amount
500 ~ 2000 nanometer range be 75% of total amount
What be greater than 2000 nanometers is 10% of total amount.
This bioglass particles is spherical as shown in Figure 1, and reunion degree is lower, and surface layer has meso-hole structure.This implement made desensitizing toothpaste profile and conventional dentifrices similar, there is good curtain coating and structural stability; 60
ounder C airtight preservation after 5 days outward appearance maintain good stability.
embodiment 2
The desensitizing gum of preparation containing bio-vitric-potassium hydrogen phosphate two component, bio-vitric surface layer meso-hole structure layer thickness is 1/4th of particle radius, and the component (mass percent, %) of chewing gum is listed as follows:
20% bioglass particles thing
2.5% potassium phosphate
15% abrasivus-silicon oxide particle thing
8% thickening agent-carboxymethyl cellulose
5% wetting agent-Polyethylene Glycol
1% foaming agent-dodecyl sodium sulfate
1% flavour enhancer-glucose
0.1% antiseptic-potassium sorbate
25% gum base-butadiene-styrene rubber
3% softening agent-Cera Flava
All the other are moisture;
Wherein, in bio-vitric, the mass percentage of each component is:
CaO 26%
SiO
240%
P
2O
5 2%
B
2O
316%
CuO 0.4%
ZnO 0.4%
K
2O 12.2%
Na
2O 3%；
Wherein, the particle size distribution range of bio-vitric:
Lower than 250 nanometers is 5% of total amount
250 ~ 500 nanometer range be 18% of total amount
500 ~ 2000 nanometer range be 65% of total amount
What be greater than 2000 nanometers is 12% of total amount.
embodiment 3
The desensitive teeth body adhesive agent of preparation containing bio-vitric-potassium phosphate two component, bio-vitric surface layer meso-hole structure layer thickness is 1/4th of particle radius, and the component (mass percent, %) of compositions is listed as follows:
25% bioglass particles thing
2% potassium dihydrogen phosphate
10% abrasivus-silicon oxide ball particulate matter
5% thickening agent-carboxymethyl cellulose
18% wetting agent-Polyethylene Glycol
0.5% foaming agent-dodecyl sodium sulfate
0.5% flavour enhancer-Mint Essence
0.1% antiseptic-potassium sorbate
All the other are moisture;
Wherein, in bio-vitric, the mass percentage of each component is:
CaO 30%
SiO
236%
P
2O
5 4%
B
2O
316%
CuO 0.2%
ZnO 0.6%
K
2O 10%
Na
2O 3.2%；
Wherein, the particle size distribution range of bio-vitric:
Lower than 250 nanometers is 5% of total amount
250 ~ 500 nanometer range be 20% of total amount
500 ~ 2000 nanometer range be 65% of total amount
What be greater than 2000 nanometers is 10% of total amount.
embodiment 4
Grain surface layer meso-hole structure layer thickness is utilized to be the bio-vitric of 1/6th of particle radius and the desensitizing toothpaste of potassium phosphate-dikalium phosphate combination of components, component (the mass percent of toothpaste, %), bioglass particles thing is 7.5 %, potassium dihydrogen phosphate is 0.5%, and potassium phosphate is 1.0%, and abrasivus is calcium carbonate granule thing 25%, the other the same as in Example 1, the desensitizing toothpaste of preparation is 60
oairtight preservation 5 days front and back under C, outward appearance remains stable.
embodiment 5
Grain surface layer meso-hole structure layer thickness is utilized to be the bio-vitric of 1/4th of particle radius and the desensitizing toothpaste of potassium phosphate-dikalium phosphate combination of components, bioglass particles thing 500 ~ 2000 nanometer range be 80% of total amount, what be greater than 2000 nanometers is 5% of total amount, abrasivus is aluminum hydroxide particles thing 20%, the other the same as in Example 1, the desensitizing toothpaste of preparation is 60
ounder C, airtight preservation 5 days front and back outward appearances remain stable.
embodiment 6
The mass percentage of component each in bio-vitric in embodiment 2 is adjusted to:
CaO 20%
SiO
248%
P
2O
5 6%
B
2O
36%
CuO 0.2%
ZnO 0.8%
K
2O 13%
Na
2O 6%；
The other the same as in Example 2, can obtain desensitizing gum.
embodiment 7
The component (mass percent, %) of tooth body adhesive agent is listed as follows:
18% bioglass particles thing
2% potassium dihydrogen phosphate
20% abrasivus-silicon oxide ball particulate matter
5% thickening agent-carboxymethyl cellulose
15% wetting agent-Polyethylene Glycol
0.3% foaming agent-dodecyl sodium sulfate
0.3% flavour enhancer-Mint Essence
0.1% antiseptic-potassium sorbate
All the other are moisture;
The other the same as in Example 3, can obtain desensitive teeth body adhesive agent.
embodiment 8
be adjusted to the compositions of sorbitol and glycerol equivalent to wetting agent in embodiment 1, other condition, with embodiment 1, prepares desensitizing toothpaste.
embodiment 9
be adjusted to equivalent silicon oxide and calcium carbonate granule thing to the abrasivus in embodiment 1, other condition, with embodiment 1, prepares desensitizing toothpaste.
embodiment 10
The mass percentage of component each in bio-vitric in embodiment 1 is adjusted to:
CaO 30%
SiO
235%
P
2O
5 6%
B
2O
318%
CuO 1.0%
ZnO 0%
K
2O 2%
Na
2O 8%；
The other the same as in Example 1, can obtain desensitizing toothpaste.
Method of testing and data:
Multi-efficiency mouth care desensitizing toothpaste prepared by embodiment 1,4,5,8,9 and 10 is detected as follows:
1) respectively 4
oc, 37
oc, 45
oc and 60
ocarry out airtight leaving standstill under C tetra-kinds of ambient temperatures, and detect standing 7 days, 14 days, 28 days and 3 months pH value to airtight toothpaste, rheological characteristics, testing result shows, and toothpaste is 4
oc, 37
oc, 45
oc leaves standstill rheological characteristic after 3 months and all there is not significant change (joining the change of toothpaste form maintenance energy than just between-2 ~ 5%), 60
oc leaves standstill form maintenance ability after 3 months and slightly declines (declining 12%); PH value remains stable after 28 days, and ascensional range is within 0.4 ± 0.1 unit, and the ascensional range that ambient temperature is high is large, but is all no more than pH10.
2) deionized water ultrasonic disperse is carried out 20 minutes by 0.1g/10 ml to the toothpaste of six embodiments, then high speed centrifugation, get supernatant and carry out heavy metal Pb and Cr content detection, through flame plasma emission spectra detection display, two heavy metal species ion concentrations, all lower than 0.1 ppm, meet oral cavity biomaterial national standard.
3) to the toothpaste of six groups of embodiments 37
oc leaves standstill the sample after 3 months, carries out cell culture fluid DMEM dispersion, 37 by 0.1g/10 ml
oc condition leaves standstill centrifuging and taking supernatant lixiviating solution after 4 hours, 0.22 micron membranes filters and does asepticize process, then conditioning cultivation is carried out to the In vitro culture L929 fibroblast of 24 hours, respectively above-mentioned lixiviating solution is connect and be diluted to 1/2,1/4,1/8 and 1/16 with standard DMEM medium, changing the cultivation of liquid time point service condition culture fluid, cultivate after 24,72 and 120 hours, use microexamination and MTT to detect cytoactive method assessment cytoactive level.Result shows, each group of lixiviate stock solution conditioning cultivation L929 cell is lower than positive controls by 13 ~ 17%, namely cytoactive is more than 80%, dilution different multiples after activity be positive controls 103 ~ 135% between, the activity of bio-vitric degraded release inorganic ions compositions to L929 cell contained in display lixiviating solution has remarkable facilitation, also show that embodiment 6 groups of toothpaste cytotoxicities are all at 1 grade, meet concerned countries standard simultaneously.
4) desensitization experiment detection is carried out, 12 Ya Min patients, male 5 people, female 7 people to the toothpaste of embodiment 1 and embodiment 4; Wherein 9 association gingival hemorrhage patients, 6 people's association eurodonticuses, the age, use every day brush teeth for twice, clean facing 2 ~ 3 minutes, then routine was gargled these two kinds of toothpaste each morning and evening all between 43 ~ 65 years old.The first step: detect odonthemodia degree with air blast after gargling 15 minutes, detected once every 3 minutes, result shows, and uses these two groups of toothpaste sensitivity of tooth half an hour degree significantly to decline, the wherein quick symptom of the basic anodontia of 10 people; Second step: association gingival hemorrhage patient is observed, at use two groups of toothpaste after 4 days, gingival hemorrhage amount declines 75%, uses 21 days afterwards substantially without gingival hemorrhage symptom; 3rd step: eurodonticus detects to association, when using 21 days, facing dental caries Streptococcus mutans declines 78%, uses and declines 92% after 42 days; 4th step: patient's long term desensitization effect is detected, during display use two groups of toothpaste 21 days, the quick reduction rate of tooth reaches 75%, and when using 35 days, patient Ya Min used eliminates substantially; Four or five step: detect for eurodonticus's facing whiteness, the patient's facing whiteness showing wherein 66% promotes very remarkable.
Multi-efficiency mouth care desensitizing gum prepared by embodiment 2 and 6 is detected as follows:
1) respectively 4
oc, 37
oc and 45
ocarry out airtight leaving standstill under C tri-kinds of ambient temperatures, and carry out pH value detection after leaving standstill 1,2 and 3 months, testing result shows, and chewing gum is undertaken 37 by 2g/10 ml
oc deionized water soaks 24 hours, and under detecting two kinds of temperature, the long-term chewing gum pH value placed remains stable substantially, and ascensional range is within 0.2 ± 0.1 unit, is all no more than pH8.8.
2) to the chewing gum of two groups of embodiments 37
oc leaves standstill the sample after 3 months, carries out cell culture fluid DMEM dispersion, 37 by 0.1g/10 ml
oc condition leaves standstill centrifuging and taking supernatant lixiviating solution after 4 hours, 0.22 micron membranes filters and does asepticize process, then conditioning cultivation is carried out to the In vitro culture L929 fibroblast of 48 hours, respectively above-mentioned lixiviating solution is connect and be diluted to 1/2,1/4,1/8 and 1/16 with standard DMEM medium, changing the cultivation of liquid time point service condition culture fluid, cultivate 24,72 and 120 hours, use MTT to detect cytoactive method assessment cytoactive level.Result shows, two groups of lixiviate stock solution conditioning cultivation L929 cells are lower than positive controls by 2 ~ 4%, namely cytoactive is more than 95%, after dilution different multiples activity be positive controls 107% ~ 122% between, the bio-vitric degraded contained in display lixiviating solution discharges the activity of inorganic ions compositions to L929 cell and has remarkable facilitation.500 μm
3) desensitization experiment detection is carried out, 20 Ya Min patients, male 8 people, female 12 people to the chewing gum of embodiment 2 and embodiment 6; Wherein 6 association gingival hemorrhage patients, 15 people's association eurodonticuses, age, between 52 ~ 67 years old, uses these two kinds of chewing-gum chewings 3 ~ 4 minutes separately, uses 5 continuously, then abandon, the first step: detect odonthemodia degree with air blast, after using chewing-gum chewing 3 times continuously, tooth sensitivity significantly declines, the wherein quick symptom of the basic anodontia of 4 people, in chew gum quick symptom of the basic anodontia of 17 people after 16 days, after 30 days, all patients lose the quick symptom of tooth.Second step: association gingival hemorrhage patient is observed, at use two groups of chewing gum after 2 days, gingival hemorrhage amount declines 47%, uses 16 days afterwards substantially without gingival hemorrhage symptom; 3rd step: eurodonticus detects to association, when using 16 days, facing dental caries Streptococcus mutans declines 92%, uses and declines 98% after 35 days; 4th step: detect for eurodonticus's facing whiteness, shows all patient's facing whiteness and promotes significantly.
Multi-efficiency mouth care desensitive teeth body adhesive agent prepared by embodiment 3 and 7 is detected as follows:
6 Ya Min patients, male 4 people, female 2 people; Wherein 2 association gingival hemorrhage patients, 5 people's association eurodonticuses, the age, use every day these two kinds of adhesive agents to be close to facing 1 hour separately, every day interval used 3 doses, then abandons between 66 ~ 78 years old.Detect odonthemodia degree with air blast, result display uses adhesive agent patient 5 days rear 2 people's sensitivity of tooth degree significantly to decline, the quick symptom of the basic anodontia of 4 people after 21 days, and after using 35 days continuously, all patients lose the quick symptom of tooth; Observe association gingival hemorrhage patient, at use two groups of adhesive agents after 8 days, gingival hemorrhage amount declines 28%, uses 42 days afterwards substantially without gingival hemorrhage symptom; To association, eurodonticus detects, and when using 3 days, facing dental caries Streptococcus mutans declines 96%, uses and declines 99% after 9 days; In addition, show all patient's facing whiteness to be all improved.
Can be found out by above data and Figure of description, desensitizing toothpaste desensitization effect prepared by embodiments of the invention is good, instant effect, and all significantly improves to association problem fond of food that is not salty.
Below be only illustrating for possible embodiments of the present invention, but this embodiment be not used to limit the scope of the claims of the present invention, allly do not depart from the equivalence that thinking of the present invention does and implement or change, all should be contained in the scope of the claims of the present invention.
Claims (10)
1. a multiple oral treatment compositions, is characterized in that: the parts by weight of the component comprised and each component are:
Bio-vitric 2-25
The phosphate 0.1-10 of potassium
Spherical in shape or the elliposoidal of described bio-vitric, granularity is 220 ~ 2500 nanometers, and the surface layer of bio-vitric exists meso-hole structure, and mesoporous pore size is 6 ~ 45 nanometers, and the parts by weight that in bio-vitric, each component represents in the form of an oxide are:
CaO 20~35；
SiO
230~38；
P
2O
5 0.1~1.8；
B
2O
312~18；
CuO 0.1~0.8；
ZnO 0~0.7；
Na
2O 0~4；
CuO and ZnO content sum account for 0.6% ~ 1.5%, K of total amount
2the ratio of the content of O and CuO and ZnO content sum is (8 ~ 30): 1.
2. multiple oral treatment compositions according to claim 1, is characterized in that: the distribution of particle sizes of bio-vitric is: the particulate matter lower than 250 nanometers is no more than 5% of total amount; The particulate matter of 250 500 nanometer range is no more than 20% of total amount; The particulate matter of 500 2000 nanometer range is not less than 65% of total amount; The particulate matter being greater than 2000 nanometers is no more than 20% of total amount.
3. multiple oral treatment compositions according to claim 1, is characterized in that: the phosphate of described potassium be in potassium phosphate, potassium hydrogen phosphate, potassium dihydrogen phosphate any one and more than.
4. multiple oral treatment compositions according to claim 1, is characterized in that: described multiple oral treatment compositions also comprises the auxiliary agent of following parts by weight:
Abrasivus 1-30;
Thickening adhesive 1-10;
Wetting agent 1 20;
Foaming agent 0.5 4.5.
5. multiple oral treatment compositions according to claim 4, is characterized in that: described abrasivus be in calcium carbonate granule thing, silicon oxide particle thing, aluminum hydroxide particles thing, dicalcium phosphate dehydrate, calcium phosphate dibasic anhydrous any one and more than.
6. multiple oral treatment compositions according to claim 4, is characterized in that: described wetting agent be Polyethylene Glycol, sorbitol, glycerol any one and more than.
7. multiple oral treatment compositions according to claim 4, is characterized in that: described foaming agent is dodecyl sodium sulfate; Described thickening adhesive is carboxymethyl cellulose.
8. multiple oral treatment compositions according to claim 1, is characterized in that: described multiple oral treatment compositions also comprises helper function vector and the moisture of 1 30 weight portions.
9. multiple oral treatment compositions according to claim 1, is characterized in that: described helper function vector be conducive to dispersion, painted, anticorrosion, increase taste, bonding, emulsifying, softening and antioxidative compound.
10. multiple oral treatment compositions according to claim 1, it is characterized in that: the preparation method of described bio-vitric is: a, nitric acid, ethyl orthosilicate, phosphate to be dissolved in deionized water successively, wherein the weight ratio of silicon, phosphorus with its oxide basis for P
2o
5: SiO
2=3:(50 ~ 285), at room temperature stir 30-60 minute, for subsequent use;
B, boric acid, calcium salt, mantoquita, zinc salt, potassium salt, sodium salt, citric acid to be dissolved in the deionized water solution of step a successively completely, 10 ~ 30 minutes, adjacent two kinds of salt joining day intervals, wherein potassium is (10 ~ 25) with oxide basis and copper and zinc with the mass ratio of oxide basis sum: 1, at room temperature stir 10 ~ 30 minutes, for subsequent use;
C, in the solution of step b, add calcium salt, phosphate and citric acid, keep copper and zinc to be 0.8% ~ 1.2% of total oxide mass with oxide basis sum, and after fully stirring 10 ~ 45 minutes again, 35 ~ 60
ostill aging 24 ~ 72 hours of C, for subsequent use;
D, by the gel after c ageing 120 ~ 180
odrying 6 ~ 24 hours under C, then 580 ~ 750
ocalcine 60 ~ 180 minutes under C, obtain bio-vitric according to claim 1.
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| WO2018033427A1 (en) * | 2016-08-19 | 2018-02-22 | Unilever N.V. | Oral care composition |
| CN108079013A (en) * | 2017-12-28 | 2018-05-29 | 东莞市鸿元医药科技有限公司 | A kind of preparation method and application for relieving pain bioactivity glass powder |
| CN108339122A (en) * | 2017-12-28 | 2018-07-31 | 东莞市鸿元医药科技有限公司 | A kind of preparation method and application of antiallergic bioactivity glass powder |
| CN109044863A (en) * | 2018-10-31 | 2018-12-21 | 四川涑爽医疗用品有限公司 | A kind of antiallergy photocatalyst beautifying and whitening toothpaste and preparation method thereof |
| CN109312209A (en) * | 2016-06-24 | 2019-02-05 | 仓敷纤维加工株式会社 | Carrier, the manufacturing method for adhering to thin film component, air filter, the manufacturing method of carrier and attachment thin film component |
| CN110755297A (en) * | 2019-11-26 | 2020-02-07 | 四川艾医生医疗科技有限公司 | High-molecular desensitizing paste and preparation method thereof |
| CN112057348A (en) * | 2019-05-23 | 2020-12-11 | 浙江大学 | Multiple composition for tooth sealing treatment |
| EA038664B1 (en) * | 2016-09-23 | 2021-09-30 | ЮНИЛЕВЕР АйПи ХОЛДИНГС Б.В. | Oral care composition |
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| WO2018033427A1 (en) * | 2016-08-19 | 2018-02-22 | Unilever N.V. | Oral care composition |
| EA038664B1 (en) * | 2016-09-23 | 2021-09-30 | ЮНИЛЕВЕР АйПи ХОЛДИНГС Б.В. | Oral care composition |
| CN108079013B (en) * | 2017-12-28 | 2021-01-26 | 东莞市鸿元医药科技有限公司 | Preparation method and application of pain-relieving bioactive glass powder |
| CN108079013A (en) * | 2017-12-28 | 2018-05-29 | 东莞市鸿元医药科技有限公司 | A kind of preparation method and application for relieving pain bioactivity glass powder |
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| CN108339122B (en) * | 2017-12-28 | 2020-12-29 | 东莞市鸿元医药科技有限公司 | Preparation method and application of anti-allergy bioactive glass powder |
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| CN112057348A (en) * | 2019-05-23 | 2020-12-11 | 浙江大学 | Multiple composition for tooth sealing treatment |
| CN112057348B (en) * | 2019-05-23 | 2022-10-18 | 浙江大学 | Multiple composition for tooth sealing treatment |
| CN110755297A (en) * | 2019-11-26 | 2020-02-07 | 四川艾医生医疗科技有限公司 | High-molecular desensitizing paste and preparation method thereof |
| CN115282063A (en) * | 2022-09-02 | 2022-11-04 | 米乐医疗科技有限公司 | Tooth desensitizer |
| CN115282063B (en) * | 2022-09-02 | 2023-11-24 | 米乐医疗科技有限公司 | Tooth desensitizer |
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