US20210130223A1 - Bioactive glass compositions and dentin hypersensitivity remediation - Google Patents
Bioactive glass compositions and dentin hypersensitivity remediation Download PDFInfo
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- US20210130223A1 US20210130223A1 US17/091,573 US202017091573A US2021130223A1 US 20210130223 A1 US20210130223 A1 US 20210130223A1 US 202017091573 A US202017091573 A US 202017091573A US 2021130223 A1 US2021130223 A1 US 2021130223A1
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- 239000000203 mixture Substances 0.000 title claims abstract description 161
- 239000005313 bioactive glass Substances 0.000 title claims abstract description 52
- 201000002170 dentin sensitivity Diseases 0.000 title abstract description 17
- 238000005067 remediation Methods 0.000 title 1
- 238000009472 formulation Methods 0.000 claims abstract description 47
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 claims description 52
- 210000004268 dentin Anatomy 0.000 claims description 36
- 238000000034 method Methods 0.000 claims description 28
- 239000000377 silicon dioxide Substances 0.000 claims description 26
- 239000000606 toothpaste Substances 0.000 claims description 26
- 229940034610 toothpaste Drugs 0.000 claims description 23
- 229910052681 coesite Inorganic materials 0.000 claims description 21
- 229910052906 cristobalite Inorganic materials 0.000 claims description 21
- 229910052682 stishovite Inorganic materials 0.000 claims description 21
- 229910052905 tridymite Inorganic materials 0.000 claims description 21
- 210000005239 tubule Anatomy 0.000 claims description 20
- PNEYBMLMFCGWSK-UHFFFAOYSA-N aluminium oxide Inorganic materials [O-2].[O-2].[O-2].[Al+3].[Al+3] PNEYBMLMFCGWSK-UHFFFAOYSA-N 0.000 claims description 15
- KKCBUQHMOMHUOY-UHFFFAOYSA-N Na2O Inorganic materials [O-2].[Na+].[Na+] KKCBUQHMOMHUOY-UHFFFAOYSA-N 0.000 claims description 14
- VSIIXMUUUJUKCM-UHFFFAOYSA-D pentacalcium;fluoride;triphosphate Chemical compound [F-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O.[O-]P([O-])([O-])=O VSIIXMUUUJUKCM-UHFFFAOYSA-D 0.000 claims description 14
- 229910052593 corundum Inorganic materials 0.000 claims description 13
- 229910001845 yogo sapphire Inorganic materials 0.000 claims description 13
- KRHYYFGTRYWZRS-UHFFFAOYSA-M Fluoride anion Chemical compound [F-] KRHYYFGTRYWZRS-UHFFFAOYSA-M 0.000 claims description 12
- BTBUEUYNUDRHOZ-UHFFFAOYSA-N Borate Chemical compound [O-]B([O-])[O-] BTBUEUYNUDRHOZ-UHFFFAOYSA-N 0.000 claims description 11
- 239000005385 borate glass Substances 0.000 claims description 10
- 239000000796 flavoring agent Substances 0.000 claims description 10
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- 239000003795 chemical substances by application Substances 0.000 claims description 6
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- 208000026935 allergic disease Diseases 0.000 claims description 5
- 230000009610 hypersensitivity Effects 0.000 claims description 5
- WUKWITHWXAAZEY-UHFFFAOYSA-L calcium difluoride Chemical compound [F-].[F-].[Ca+2] WUKWITHWXAAZEY-UHFFFAOYSA-L 0.000 claims description 4
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- 229910001631 strontium chloride Inorganic materials 0.000 description 1
- AHBGXTDRMVNFER-UHFFFAOYSA-L strontium dichloride Chemical compound [Cl-].[Cl-].[Sr+2] AHBGXTDRMVNFER-UHFFFAOYSA-L 0.000 description 1
- OGIDPMRJRNCKJF-UHFFFAOYSA-N titanium oxide Inorganic materials [Ti]=O OGIDPMRJRNCKJF-UHFFFAOYSA-N 0.000 description 1
- 210000001036 tooth cervix Anatomy 0.000 description 1
- 230000000699 topical effect Effects 0.000 description 1
- 239000002966 varnish Substances 0.000 description 1
- 230000029663 wound healing Effects 0.000 description 1
- 239000000811 xylitol Substances 0.000 description 1
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 description 1
- 229960002675 xylitol Drugs 0.000 description 1
- 235000010447 xylitol Nutrition 0.000 description 1
- 229910052726 zirconium Inorganic materials 0.000 description 1
Images
Classifications
-
- C—CHEMISTRY; METALLURGY
- C03—GLASS; MINERAL OR SLAG WOOL
- C03C—CHEMICAL COMPOSITION OF GLASSES, GLAZES OR VITREOUS ENAMELS; SURFACE TREATMENT OF GLASS; SURFACE TREATMENT OF FIBRES OR FILAMENTS MADE FROM GLASS, MINERALS OR SLAGS; JOINING GLASS TO GLASS OR OTHER MATERIALS
- C03C4/00—Compositions for glass with special properties
- C03C4/0007—Compositions for glass with special properties for biologically-compatible glass
- C03C4/0021—Compositions for glass with special properties for biologically-compatible glass for dental use
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K6/00—Preparations for dentistry
- A61K6/20—Protective coatings for natural or artificial teeth, e.g. sealings, dye coatings or varnish
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K6/00—Preparations for dentistry
- A61K6/70—Preparations for dentistry comprising inorganic additives
- A61K6/71—Fillers
- A61K6/77—Glass
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K6/00—Preparations for dentistry
- A61K6/80—Preparations for artificial teeth, for filling teeth or for capping teeth
- A61K6/831—Preparations for artificial teeth, for filling teeth or for capping teeth comprising non-metallic elements or compounds thereof, e.g. carbon
- A61K6/836—Glass
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/20—Halogens; Compounds thereof
- A61K8/21—Fluorides; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/25—Silicon; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/26—Aluminium; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
-
- C—CHEMISTRY; METALLURGY
- C03—GLASS; MINERAL OR SLAG WOOL
- C03C—CHEMICAL COMPOSITION OF GLASSES, GLAZES OR VITREOUS ENAMELS; SURFACE TREATMENT OF GLASS; SURFACE TREATMENT OF FIBRES OR FILAMENTS MADE FROM GLASS, MINERALS OR SLAGS; JOINING GLASS TO GLASS OR OTHER MATERIALS
- C03C3/00—Glass compositions
- C03C3/04—Glass compositions containing silica
- C03C3/062—Glass compositions containing silica with less than 40% silica by weight
- C03C3/064—Glass compositions containing silica with less than 40% silica by weight containing boron
-
- C—CHEMISTRY; METALLURGY
- C03—GLASS; MINERAL OR SLAG WOOL
- C03C—CHEMICAL COMPOSITION OF GLASSES, GLAZES OR VITREOUS ENAMELS; SURFACE TREATMENT OF GLASS; SURFACE TREATMENT OF FIBRES OR FILAMENTS MADE FROM GLASS, MINERALS OR SLAGS; JOINING GLASS TO GLASS OR OTHER MATERIALS
- C03C3/00—Glass compositions
- C03C3/04—Glass compositions containing silica
- C03C3/076—Glass compositions containing silica with 40% to 90% silica, by weight
- C03C3/097—Glass compositions containing silica with 40% to 90% silica, by weight containing phosphorus, niobium or tantalum
Definitions
- the disclosure relates to a glass composition, a bioactive glass composition, and to methods of making and using the compositions.
- the disclosure provides a glass composition, a bioactive glass composition, a bioactive dental formulation (e.g., toothpaste), and to methods of making and using the compositions.
- a bioactive dental formulation e.g., toothpaste
- the disclosure provides a composition and method for treating dentin hypersensitivity.
- the disclosure provides a group of borate and borosilicate bioactive glasses, an oral care product, for example, a toothpaste, a mouthwash, and like formulations, for the treatment of dentin hypersensitivity.
- the disclosure provides a glass composition that has a significantly higher rate of occluding of exposed dentin tubules than a 45S5-containing toothpaste, demonstrating excellent properties for treating dentin hypersensitivity.
- the present disclosure provides: a bioactive glass composition as defined herein, including or excluding selected source additives.
- FIG. 1 shows a hypothetical scheme of chemical and physical action of the disclosed bioactive composition.
- FIGS. 2A to 2F show SEM micrographs of test dentin discs after 1 week treatment with various formulations.
- FIGS. 3A to 3C show SEM-EDS analysis of dentin deposition after a 1 week treatment with an Example 1 containing toothpaste formulation.
- compositions, articles, and methods of making and using provide one or more advantageous features or aspects, including for example as discussed below.
- Features or aspects recited in any of the claims are generally applicable to all facets of the invention. Any recited single or multiple feature or aspect in any one claim can be combined or permuted with any other recited feature or aspect in any other claim or claims.
- DH dipalmitoyl sensitivity
- DS osmotic stimuli
- Glass Glass, “glasses,” or like terms can refer to a glass or a glass-ceramic.
- Glass article can refer to any object made wholly or partly of glass or a glass-ceramic.
- “Flavorant,” “flavor” or like terms can refer to any natural or synthetic substance that provides organoleptic properties to the disclosed composition when a user has contact with the composition.
- the flavorant can be, for example, a single compound or a mixture of compounds.
- the flavorant can be selected to give the composition or product a unique flavor or to maintain flavor consistency between different product batches or after recipe changes.
- the flavorant can be any known or discovered compound, for example, diacetyl, acetylpropionyl, acetoin, isoamyl acetate, benzaldehyde, cinnamaldehyde, ethyl propionate, methyl anthranilate, limonene, ethyl decadienoate, allyl hexanoate, ethyl maltol, ethyl vanillin, methyl salicylate, and like compounds, or mixtures thereof.
- composition components or formulation ingredients are known to one of skill in the art such as an abrasive, a humectant, a colorant, an antibacterial agent, a surfactant, a whitening agent, a binder, and like components or ingredients, see for example, en.wikipedia.org/wiki/Toothpaste.
- Angiogenesis ability refers to the physiological process by which new blood vessels form from pre-existing vessels.
- the term “about” also encompasses amounts that differ due to aging of a composition or formulation with a particular initial concentration or mixture, and amounts that differ due to mixing or processing a composition or formulation with a particular initial concentration or mixture.
- indefinite article “a” or “an” and its corresponding definite article “the” as used herein means at least one, or one or more, unless specified otherwise.
- compositions and methods of the disclosure can include any value or any combination of the values, specific values, more specific values, and preferred values described herein, including explicit or implicit intermediate values and ranges.
- Dentin hypersensitivity is a global oral health issue and its treatment remains a significant challenge for most dental professionals. Dentin hypersensitivity is caused by the absence of the smear layer of dentin tubules, which exposes dentinal tubules to thermal, chemical, mechanical, or osmotic stimuli. The movement of the fluid within the tubules stimulates mechanical receptors that are sensitive to fluid pressure, resulting in the transmission of the stimuli to the pulpal nerves and ultimately the pain response. Dentin hypersensitivity can generally be treated, for example, by chemical desensitization of the tooth nerve endings, tubule occluding agents or barriers to reduce dentin permeability, or both (see S. B.
- Current tubule occluding agents include fluorides (i.e., formation of calcium fluoride crystals), oxalates (i.e., formation of calcium oxalate), and strontium chloride (i.e., has affinity for dentine due to the high permeability and possibility for absorption into or onto the organic connective tissues and the odontoblast processes) (see S. Miglani, supra.).
- Pro-Argin-based toothpastes can form a dentin-like mineral deposition layer due to the binding of arginine and calcium carbonate to the negatively charged dentine surface (see R Kulal, “An in-vitro comparison of nano hydroxyapatite, Novamin and Proargin desensitizing toothpastes—a SEM study” J Clin Diagn Res, 2016, 10(10): ZC51-ZC54).
- silicate glass based toothpastes such as Novamin® and BioMin® (having for example less than 40% mol SiO 2 , greater than 8% mol P 2 O 5 ), were found to react with saliva and release calcium, phosphate, or in the presence of fluoride ions to form hydroxycarbonated apatite or fluorapatite, respectively, over the exposed dentin and within dentin tubules (see S. Miglani, supra.; L. J. Litkowski, “Compositions containing bioactive glass and their use in treating tooth hypersensitivity,” U.S. Pat. No. 6,338,751; and R. Hill, “Bioactive glass composition,” U.S. Pat. No. 9,168,272)(see also H. E.
- Dentin treatment using bioactive glass-containing toothpastes is believed to be the only treatment method that can provide long period protection. Unlike other occluding reagents of dentin tubules, a bioactive glass can reliably relieve the pain of dental hypersensitivity for extended periods permanently.
- Recently developed aluminoborate glasses have been demonstrated to have excellent biocompatability, enhanced angiogenesis, and can promote wound healing, see for example, the abovementioned commonly owned and assigned copending patent applications: 62/342,411 and 62/342,384.
- the present disclosure provides an array of borate and borosilicate glass compositions that have superior properties and a capacity to treat dentin hypersensitivity compared to known bioactive glasses.
- the present disclosure provides a dental formulation, for example, for oral topical applications, comprising:
- a bioactive glass composition in an effective amount, e.g., from 0.1 to 10 wt %, comprising a source of:
- the mol % of the source has the equivalent weight percentages of 1 to 60% B2O 3 , 1 to 60% SiO 2 , 2 to 20% Al 2 O 3 , 5 to 25% CaO, 1 to 10% P 2 O 5 , 1 to 20% Na 2 O, 1 to 25% K 2 O, and 1 to 15% MgO, based on a 100 wt % total of the composition.
- the disclosure provides a bioactive glass comprising a source of from 5 to 50 mol % SiO 2 (4 to 40 wt %), and the suitable carrier comprises a source of from 5 to 25 mol % SiO 2 (4 to 20 wt %) (e.g., as an abrasive), based on a 100 mol % (100 wt %) total of the composition.
- the disclosure provides a dental formulation composition further comprising a source of fluoride ion in an amount of from 1 to 25 mol % (1 to 30 wt %) (see, e.g., U.S. Pat. No. 9,168,272).
- the disclosure provides a dental formulation composition wherein the source of fluoride ion is selected, for example, from NaF, SnF 2 , CaF 2 , and like sources, or a mixture of selected sources.
- the disclosed bioactive glass composition and dental formulation composition containing the disclosed bioactive glass composition can be substantially free-of or entirely free-of a source of fluoride ion.
- the disclosed bioactive composition and dental formulation composition containing the disclosed bioactive glass composition can be substantially free-of or entirely free-of a source of titanium oxide.
- the disclosure provides a dental formulation composition wherein the bioactive glass composition in an effective amount is from 1 to 20 wt % (e.g., from 1 to 10 wt %) and the suitable carrier in an effective amount is from 80 to 99 wt % (e.g., from 90 to 99 wt %).
- the disclosure provides a preferred dental formulation composition wherein the bioactive glass composition comprises:
- the mol % of the source has the equivalent weight percentages of 30 to 50% B2O 3 , 0.1 to 5% SiO 2 , 8 to 15% Al 2 O 3 , 15 to 25% CaO, 1.5 to 5% P 2 O 5 , 4 to 8% Na 2 O, 6 to 15% K 2 O, and 3 to 8% MgO, based on a 100 wt % total of the composition.
- the disclosure provides a dental formulation composition
- the suitable carrier comprises one or more ingredients selected from: an abrasive, a humectant, i.e., an anti-drying agent such as glycerol, sorbitol, xylitol, 1,2-propylene glycol, polyethyleneglycol, and like compounds, a flavorant, a colorant, an antibacterial agent, a surfactant, a whitening agent, and other like suitable ingredients known in the art, or a mixture thereof.
- an abrasive e., a humectant, i.e., an anti-drying agent such as glycerol, sorbitol, xylitol, 1,2-propylene glycol, polyethyleneglycol, and like compounds
- a flavorant e.e., glycerol, sorbitol, xylitol, 1,2-propylene glycol, polyethyleneglycol, and like compounds
- a flavorant
- the disclosure provides a dental formulation composition wherein the suitable carrier comprises one or more forms selected from: a gum, a paste, a powder, a toothpaste, a mouthwash, a poultice, a tea, a sucker, a spray, and like forms, or a mixture thereof.
- the suitable carrier comprises one or more forms selected from: a gum, a paste, a powder, a toothpaste, a mouthwash, a poultice, a tea, a sucker, a spray, and like forms, or a mixture thereof.
- the disclosure provides a remineralizing composition
- a remineralizing composition comprising: any one of the abovementioned bioactive glass compositions or combinations thereof, and optionally a suitable carrier such as non-aqueous carrier for the remineralizing composition.
- the disclosure provides a remineralizing composition comprising: the abovementioned bioactive glass composition and an optional suitable carrier.
- the disclosure provides a method of treating dentin hypersensitivity or sensitivity comprising:
- the contacting the dental formulation has a higher relative rate of from 50 to 95% of occluding exposed dentin tubules compared to a dental formulation base formula that is free-of the bioactive glass, i.e., without the bioactive glass present.
- contacting the dental formulation can be selected from at least one of: polishing with a paste formula, rinsing with a liquid formula, injecting with a liquid formula, filling a tooth with a composite, e.g., typically made of powdered bioactive glass and acrylic resin, or a combination thereof.
- the dental surface can have at least one of, for example: a dentin surface, a dentin tubule, or a combination thereof.
- the disclosure provides a dental formulation comprising:
- the mol % of the source has the equivalent weight percentages of 1 to 60% B 2 O 3 , 1 to 60% SiO 2 , 2 to 20% Al 2 O 3 , 5 to 25% CaO, 1 to 10% P 2 O 5 , 1 to 20% Na 2 O, 1 to 25% K 2 O, and 1 to 15% MgO, based on a 100 wt % total of the composition.
- the dental formulation is free of silica such as a source of SiO 2 , and free of inorganic potassium salts such as a source of K 2 O.
- the present disclosure is advantaged in several aspects, including for example: the disclosed borate and borosilicate glass compositions can have a significantly higher rate of occluding of the exposed dentin tubules compared to a 45S5-containing toothpaste, which result(s) demonstrate excellent potential of the disclosed bioactive glass for treating dentin hypersensitivity or dentin sensitivity; the disclosed bioactive glass compositions can be free-of inorganic potassium salts, and the disclosed bioactive glass compositions, and dentin treatment formulations, can be silicate free. Novamin® and Biomin® are silicate-containing bioactive glasses.
- the disclosure provides borate and borosilicate bioactive glass compositions, for example, as listed in Table 1, that can react with mammalian saliva and can release calcium and phosphate to form hydroxycarbonated apatite, or if fluoride ions are present to form fluorapatite (see FIG. 2 and FIG. 3 ), exhibiting tubule occlusion at the surface by the formation of a smear layer and within dentin tubules, and rebuild, strengthen, and protect tooth structure.
- Normal enamel and dentin contain, for example, 0.44 and 1.23 wt % of magnesium, respectively.
- Magnesium is a co-factor for many enzymes, and stabilizes the structures of DNA and RNA. Magnesium may have stimulatory effects on the tooth development and maintenance.
- Fluoride can be incorporated into the glass compositions in a precursor form of, for example, sodium fluoride (NaF), stannous fluoride (SnF 2 ), calcium fluoride (CaF 2 ), and like fluorides or mixtures thereof.
- the fluoride incorporated glasses can release fluoride and form fluorapatite in an oral fluid. Fluorapatite is more resistant to acid dissolution than hydroxycarbonated apatite.
- the fluoride incorporated glasses can also be added into non-aqueous dentifrice matrix, for example, in combination with another bioactive glass.
- Fluoride ions are known to aid apatite formation and can stimulate osteoblast division.
- the disclosed glass compositions and formulations can also be antimicrobial, which property permits, for example, prevention of dental caries, reduce plaque formation, control gingivitis, suppress breath malodor, and like beneficial effects.
- the disclosed glass compositions and formulations can also be incorporated in other professionally applied dental products, such as cleaning and polishing pastes, varnishes, re-mineralizing filling materials, and like formulations.
- the disclosure provides a remineralizing composition comprising, for example:
- a bioactive glass composition in an effective amount, e.g., from 0.1 to 10 wt %, comprising a source of:
- the mol % of the source has the equivalent weight percentages of 1 to 60% B 2 O 3 , 1 to 60% SiO 2 , 2 to 20% Al 2 O 3 , 5 to 25% CaO, 1 to 10% P 2 O 5 , 1 to 20% Na 2 O, 1 to 25% K 2 O, and 1 to 15% MgO, based on a 100 wt % total of the composition.
- FIG. 1 shows a hypothetical scheme of chemical and physical action of the disclosed bioactive composition.
- the mechanism of action although not limited by theory, is believed to include, for example: the bioactive glass particles react with saliva or water to exchange ions, e.g., Na + , K + , and like ions, with H + , and raise the pH ( 100 ); calcium and phosphate precipitate as calcium-phosphate ( 110 ); and calcium-phosphate, or fluoride if present, crystallize to form hydroxycarbonated apatite or fluorapatite on the dentin surface or within the dentin tubules ( 120 ).
- FIGS. 2A to 2F show SEM micrographs of test dentin discs after 1 week treatment: with a base toothpaste formulation ( 2 A, 2 B); a 45S5-containing toothpaste ( 2 C, 2 D); or an Example 1 containing toothpaste ( 2 E, 2 F), and immersion in artificial saliva. There was no occluding of dentin tubules for the base toothpaste treatment. After treatment with the 45S5 containing toothpaste, dentin tubules were partially occluded by crystal-like deposits. After treatment with the Example 1 containing toothpaste, most dentin tubules and dentin surface were occluded by crystal-like deposits.
- FIGS. 3A to 3C show SEM-EDS analysis of dentin deposition after a 1 week treatment with the Example 1 containing toothpaste.
- FIG. 3A shows the SEM having two points selected (black circles added) for further analysis.
- SEM-EDS analysis showed the apatite formed on and within the dentin tubules were calcium and phosphate precipitate and small trace of magnesium (see FIGS. 3B (point 003 ) and 3 C (point 004 )).
- Each glass composition of Table 1 was separately melted and ground to 1 to 10 microns using, for example, an air jet mill.
- Each ground glass composition of Table 1 was separately formulated into a dental formulation such as listed in Table 2.
- Each dental formulation was evaluated for the ability to occlude dentine discs made of human molars as detailed in Example 9, i.e., the discs having dentin tubules were exposed to the dental formulation and compared to a dental formulation base (control) that was free-of the disclosed bioactive glass.
- Base Toothpaste Ingredients (control) (base + BG*) glycerol 69.02 64.02 sodium lauryl sulphate 1.1 1.1 PEG400 20 20 silicon dioxide 8 8 *bioactive glass (BG) — 5 carbopol 940 0.5 0.5 sodium saccharin 0.35 0.35 flavor 1.03 1.03 Total (wt %) 100 100
- Raw materials, equipment, or both, used to produce the compositions of the present disclosure can introduce certain impurities or components that are not intentionally added, and can be present in the final glass composition. Such materials can be present in the disclosed compositions in minor amounts and are referred to as “tramp materials.”
- compositions can comprise the tramp materials, typically in trace amounts.
- iron-free “sodium-free,” “lithium-free,” “zirconium-free,” “alkali earth metal-free,” “heavy metal-free,” or like descriptions, mean that the tramp material was not purposefully added to the composition, but the composition may still comprise iron, sodium, lithium, zirconium, alkali earth metals, or heavy metals, etc., but in approximately tramp or trace amounts.
- Example 1 in Table 1 The composition of Example 1 in Table 1 was prepared as follows: The source batch materials in the indicated amounts, including silicon dioxide, boric acid, alumina, sodium oxide, potassium oxide, limestone, magnesium oxide, and calcium phosphate, were individually combined. The batch source materials were vigorously mixed in a plastic jar using a Turbular mixer. Then they were transferred to a platinum crucible with an internal volume of approximately 650 cc. The crucible was then loaded into an annealing furnace to calcine the batch at 250° C. for 24 hr. The calcined batches were then melted at 1100 to 1300° C. for 6 hr and then the glass melt was poured on a steel plate, and annealed at 400 to 500° C.
- Glasses 2 through 6 were likewise prepared as in Example 1 with the exception that the composition or amount used in the batch was different and as listed in Table 1.
- Comparative Example 7 in Table 1 was prepared as in Example 1 with the exception that: there is no boric acid or alumina batched in the comparative glass, see for example US 20140186274, which mentions a non-aqueous base composition in combination with a bioactive glass.
- the dental formulations of Table 2 were prepared as follows: Glycerol and PEG 400 were added to the glass composition first, then the remaining ingredients of the formulation were separately added and thoroughly mixed with a spatula.
- the dental formulations of Table 2 were evaluated as follows: Human molars were lawfully obtained from bforbones (bforbones.com). Dentine discs having a thickness of 1 mm were cut perpendicularly to the long axis of the tooth above the cemento-enamel junction using a Buehler low-speed water cooled diamond saw. A smear layer was created on both sides of the dentine discs by sanding 30 seconds using 500-grit sanding paper. The smear was subsequently removed by treating with 6% citric acid for 3 mins, then rinsed with water, and dried at 37° C.
- the dentine discs were randomly divided into control or experiment groups, each containing at least 3 specimens, which received either a non-aqueous toothpaste base formulation or a toothpaste containing 5% of 45S5; and the toothpaste containing a disclosed glass composition, as listed in Tables 1 and 2.
- the toothpaste and a powered tooth brush were used to brush against both sides of the dentin discs for 1 min per side.
- the specimens were then rinsed with distilled water to remove visible traces of toothpaste, and then stored in artificial saliva (1.5 mM CaCl 2 ), 0.9 mM KH 2 PO 4 , 130 mM KCl, and 20 mM HEPES with pH 7.4).
- the procedure of brushing, rinsing, and storing each specimen in artificial saliva was repeated twice a day for 7 days, then the specimens were dried at 37° C. for 16 hrs and stored at RT before SEM.
Abstract
A dental formulation including: a bioactive glass composition as defined herein, in an effective amount; and a suitable carrier as defined herein, in an effective amount. Also disclosed is a method of making and using the dental formulation to treat, for example, dentin sensitivities.
Description
- This application is a Continuation of U.S. application Ser. No. 16/203,002, filed on Nov. 28, 2018, which claims the benefit of priority under 35 U.S.C. § 119 of U.S. Provisional Patent Application No. 62/591,423 filed Nov. 28, 2017, the content of which is incorporated herein by reference in its entirety.
- The present application is related commonly owned and assigned USSN Provisional application Nos., filed May 25, 2016:
- 62/342,384, entitled “BIOACTIVE ALUMINOBORATE GLASSES”;
- 62/342,377, entitled “MAGNETIZABLE GLASS CERAMIC COMPOSITION AND METHODS THEREOF”;
- 62/342,381, entitled “LITHIUM DISILICATE GLASS-CERAMIC COMPOSITIONS AND METHODS THEREOF”;
- 62/342,391, entitled “BIODEGRADABLE MICROBEADS”; and
- 62/342,411, entitled “BIOACTIVE GLASS MICROSPHERES”; but does not claim priority thereto.
- The present application is also related to commonly owned and assigned USSN Application No. 62/189,880, filed Jul. 7, 2015, entitled “ANTIMICROBIAL PHASE-SEPARATING GLASS AND GLASS CERAMIC ARTICLES AND LAMINATES,” which mentions a copper containing laminate having a degradable phase, which phase liberates cooper ion, and a non-degradable phase, but does not claim priority thereto.
- The present application is also related commonly owned and assigned USSN application Nos.:
- 62/591,446, filed Nov. 28, 2017, entitled “HIGH LIQUIDUS VISCOSITY BIOACTIVE GLASS”; and
- 62/591,438, filed Nov. 28, 2017, entitled “CHEMICALLY STRENGTHENED BIOACTIVE GLASS-CERAMICS”;
- 62/591,429, filed Nov. 28, 2017, entitled “BIOACTIVE BORATE GLASS AND METHODS THEREOF”, filed concurrently herewith, but does not claim priority thereto.
- The entire disclosure of each publication or patent document mentioned herein is incorporated by reference.
- The disclosure relates to a glass composition, a bioactive glass composition, and to methods of making and using the compositions.
- In embodiments, the disclosure provides a glass composition, a bioactive glass composition, a bioactive dental formulation (e.g., toothpaste), and to methods of making and using the compositions.
- In embodiments, the disclosure provides a composition and method for treating dentin hypersensitivity.
- In embodiments, the disclosure provides a group of borate and borosilicate bioactive glasses, an oral care product, for example, a toothpaste, a mouthwash, and like formulations, for the treatment of dentin hypersensitivity.
- In embodiments, the disclosure provides a glass composition that has a significantly higher rate of occluding of exposed dentin tubules than a 45S5-containing toothpaste, demonstrating excellent properties for treating dentin hypersensitivity.
- In embodiments, the present disclosure provides: a bioactive glass composition as defined herein, including or excluding selected source additives.
- In embodiments of the disclosure:
-
FIG. 1 shows a hypothetical scheme of chemical and physical action of the disclosed bioactive composition. -
FIGS. 2A to 2F show SEM micrographs of test dentin discs after 1 week treatment with various formulations. -
FIGS. 3A to 3C show SEM-EDS analysis of dentin deposition after a 1 week treatment with an Example 1 containing toothpaste formulation. - Various embodiments of the disclosure will be described in detail with reference to drawings, if any. Reference to various embodiments does not limit the scope of the invention, which is limited only by the scope of the claims attached hereto. Additionally, any examples set forth in this specification are not limiting and merely set forth some of the many possible embodiments of the claimed invention.
- In embodiments, the disclosed compositions, articles, and methods of making and using provide one or more advantageous features or aspects, including for example as discussed below. Features or aspects recited in any of the claims are generally applicable to all facets of the invention. Any recited single or multiple feature or aspect in any one claim can be combined or permuted with any other recited feature or aspect in any other claim or claims.
- “Dentin hypersensitivity,” (DH) “dentin sensitivity,” (DS) or like terms refer to a short, sharp pain caused by cold and heat, air, touch, or chemical or osmotic stimuli, e.g., sweets.
- “Occlude,” “occluding,” “occlusion,” or like terms refer, for example, to close up or block off, to obstruct.
- “Glass,” “glasses,” or like terms can refer to a glass or a glass-ceramic.
- “Glass article,” or like terms can refer to any object made wholly or partly of glass or a glass-ceramic.
- “Flavorant,” “flavor” or like terms can refer to any natural or synthetic substance that provides organoleptic properties to the disclosed composition when a user has contact with the composition. The flavorant can be, for example, a single compound or a mixture of compounds. The flavorant can be selected to give the composition or product a unique flavor or to maintain flavor consistency between different product batches or after recipe changes. The flavorant can be any known or discovered compound, for example, diacetyl, acetylpropionyl, acetoin, isoamyl acetate, benzaldehyde, cinnamaldehyde, ethyl propionate, methyl anthranilate, limonene, ethyl decadienoate, allyl hexanoate, ethyl maltol, ethyl vanillin, methyl salicylate, and like compounds, or mixtures thereof.
- Other typical composition components or formulation ingredients are known to one of skill in the art such as an abrasive, a humectant, a colorant, an antibacterial agent, a surfactant, a whitening agent, a binder, and like components or ingredients, see for example, en.wikipedia.org/wiki/Toothpaste.
- “Angiogenesis ability,” “angiogenic,” “angiogenesis,” or like terms, refer to the physiological process by which new blood vessels form from pre-existing vessels.
- “Include,” “includes,” or like terms means encompassing but not limited to, that is, inclusive and not exclusive.
- “About” modifying, for example, the quantity of an ingredient in a composition, concentrations, volumes, process temperature, process time, yields, flow rates, pressures, viscosities, and like values, and ranges thereof, or a dimension of a component, and like values, and ranges thereof, employed in describing the embodiments of the disclosure, refers to variation in the numerical quantity that can occur, for example: through typical measuring and handling procedures used for preparing materials, compositions, composites, concentrates, component parts, articles of manufacture, or use formulations; through inadvertent error in these procedures; through differences in the manufacture, source, or purity of starting materials or ingredients used to carry out the methods; and like considerations. The term “about” also encompasses amounts that differ due to aging of a composition or formulation with a particular initial concentration or mixture, and amounts that differ due to mixing or processing a composition or formulation with a particular initial concentration or mixture.
- “Optional” or “optionally” means that the subsequently described event or circumstance can or cannot occur, and that the description includes instances where the event or circumstance occurs and instances where it does not.
- The indefinite article “a” or “an” and its corresponding definite article “the” as used herein means at least one, or one or more, unless specified otherwise.
- Abbreviations, which are well known to one of ordinary skill in the art, may be used (e.g., “h” or “hrs” for hour or hours, “g” or “gm” for gram(s), “mL” for milliliters, and “rt” for room temperature, “nm” for nanometers, and like abbreviations).
- Specific and preferred values disclosed for components, ingredients, additives, dimensions, conditions, times, and like aspects, and ranges thereof, are for illustration only; they do not exclude other defined values or other values within defined ranges. The composition and methods of the disclosure can include any value or any combination of the values, specific values, more specific values, and preferred values described herein, including explicit or implicit intermediate values and ranges.
- Dentin hypersensitivity is a global oral health issue and its treatment remains a significant challenge for most dental professionals. Dentin hypersensitivity is caused by the absence of the smear layer of dentin tubules, which exposes dentinal tubules to thermal, chemical, mechanical, or osmotic stimuli. The movement of the fluid within the tubules stimulates mechanical receptors that are sensitive to fluid pressure, resulting in the transmission of the stimuli to the pulpal nerves and ultimately the pain response. Dentin hypersensitivity can generally be treated, for example, by chemical desensitization of the tooth nerve endings, tubule occluding agents or barriers to reduce dentin permeability, or both (see S. B. Low, “Reduction in dental hypersensitivity with nano-hydroxyapatite, potassium nitrate, sodium monoflurophosphate and antioxidants,” Open Dent J, 2015; (9): 92-97; S. Miglani, “Dentin hypersensitivity: Recent trends in management,” J Consery Dent. 2010, 13(4): 218-224; A. R. Davari, “Dentin hypersensitivity: Etiology, diagnosis and treatment; a literature review,” J Dent (Shiraz), 2013, 14(3): 136-145). The use of potassium nitrate (KNO3) as a chemical desensitization agent can eliminate the potassium ion concentration gradient across the nerve cell membrane. Therefore, the nerve cells will not depolarize and will not respond to stimuli (see S. B. Low, supra.). Current tubule occluding agents include fluorides (i.e., formation of calcium fluoride crystals), oxalates (i.e., formation of calcium oxalate), and strontium chloride (i.e., has affinity for dentine due to the high permeability and possibility for absorption into or onto the organic connective tissues and the odontoblast processes) (see S. Miglani, supra.). Additionally, Pro-Argin-based toothpastes can form a dentin-like mineral deposition layer due to the binding of arginine and calcium carbonate to the negatively charged dentine surface (see R Kulal, “An in-vitro comparison of nano hydroxyapatite, Novamin and Proargin desensitizing toothpastes—a SEM study” J Clin Diagn Res, 2016, 10(10): ZC51-ZC54). Recently, silicate glass based toothpastes such as Novamin® and BioMin® (having for example less than 40% mol SiO2, greater than 8% mol P2O5), were found to react with saliva and release calcium, phosphate, or in the presence of fluoride ions to form hydroxycarbonated apatite or fluorapatite, respectively, over the exposed dentin and within dentin tubules (see S. Miglani, supra.; L. J. Litkowski, “Compositions containing bioactive glass and their use in treating tooth hypersensitivity,” U.S. Pat. No. 6,338,751; and R. Hill, “Bioactive glass composition,” U.S. Pat. No. 9,168,272)(see also H. E. Strassler, et al., “Dentinal Hypersensitivity: Etiology, Diagnosis and Management” Contin. Ed. Pub.; and M. Han, et al., “In vivo remineralization of dentin using an agarose hydrogel biomimetic mineralization system,” 7 Feb. 2017, in nature.com/srep/).
- Dentin treatment using bioactive glass-containing toothpastes is believed to be the only treatment method that can provide long period protection. Unlike other occluding reagents of dentin tubules, a bioactive glass can reliably relieve the pain of dental hypersensitivity for extended periods permanently. Recently developed aluminoborate glasses have been demonstrated to have excellent biocompatability, enhanced angiogenesis, and can promote wound healing, see for example, the abovementioned commonly owned and assigned copending patent applications: 62/342,411 and 62/342,384.
- In embodiments, the present disclosure provides an array of borate and borosilicate glass compositions that have superior properties and a capacity to treat dentin hypersensitivity compared to known bioactive glasses.
- In embodiments, the present disclosure provides a dental formulation, for example, for oral topical applications, comprising:
- a bioactive glass composition in an effective amount, e.g., from 0.1 to 10 wt %, comprising a source of:
- 2 to 70% B2O3,
- 1 to 60% SiO2,
- 2 to 16% Al2O3,
- 5 to 30% CaO,
- 1 to 6% P2O5,
- 1 to 20% Na2O,
- 1 to 20% K2O, and
- 1 to 20% MgO, based on a 100 mol % total of the composition; and
- a suitable carrier, in an effective amount of from 99.9 to 90 wt % based on a 100 wt % total of the composition. The mol % of the source has the equivalent weight percentages of 1 to 60% B2O3, 1 to 60% SiO2, 2 to 20% Al2O3, 5 to 25% CaO, 1 to 10% P2O5, 1 to 20% Na2O, 1 to 25% K2O, and 1 to 15% MgO, based on a 100 wt % total of the composition.
- In embodiments, the disclosure provides a bioactive glass comprising a source of from 5 to 50 mol % SiO2 (4 to 40 wt %), and the suitable carrier comprises a source of from 5 to 25 mol % SiO2 (4 to 20 wt %) (e.g., as an abrasive), based on a 100 mol % (100 wt %) total of the composition.
- In embodiments, the disclosure provides a dental formulation composition further comprising a source of fluoride ion in an amount of from 1 to 25 mol % (1 to 30 wt %) (see, e.g., U.S. Pat. No. 9,168,272).
- In embodiments, the disclosure provides a dental formulation composition wherein the source of fluoride ion is selected, for example, from NaF, SnF2, CaF2, and like sources, or a mixture of selected sources.
- In embodiments, the disclosed bioactive glass composition and dental formulation composition containing the disclosed bioactive glass composition can be substantially free-of or entirely free-of a source of fluoride ion.
- In embodiments, the disclosed bioactive composition and dental formulation composition containing the disclosed bioactive glass composition can be substantially free-of or entirely free-of a source of titanium oxide.
- In embodiments, the disclosure provides a dental formulation composition wherein the bioactive glass composition in an effective amount is from 1 to 20 wt % (e.g., from 1 to 10 wt %) and the suitable carrier in an effective amount is from 80 to 99 wt % (e.g., from 90 to 99 wt %).
- In embodiments, the disclosure provides a preferred dental formulation composition wherein the bioactive glass composition comprises:
- 40 to 60% B2O3,
- 0.1 to 5% SiO2,
- 6 to 10% Al2O3,
- 15 to 25% CaO,
- 1.5 to 2.0% P2O5,
- 4 to 8% Na2O,
- 6 to 10% K2O, and
- 6 to 10% MgO, based on a 100 mol % total of the composition. The mol % of the source has the equivalent weight percentages of 30 to 50% B2O3, 0.1 to 5% SiO2, 8 to 15% Al2O3, 15 to 25% CaO, 1.5 to 5% P2O5, 4 to 8% Na2O, 6 to 15% K2O, and 3 to 8% MgO, based on a 100 wt % total of the composition.
- In embodiments, the disclosure provides a dental formulation composition wherein the suitable carrier comprises one or more ingredients selected from: an abrasive, a humectant, i.e., an anti-drying agent such as glycerol, sorbitol, xylitol, 1,2-propylene glycol, polyethyleneglycol, and like compounds, a flavorant, a colorant, an antibacterial agent, a surfactant, a whitening agent, and other like suitable ingredients known in the art, or a mixture thereof.
- In embodiments, the disclosure provides a dental formulation composition wherein the suitable carrier comprises one or more forms selected from: a gum, a paste, a powder, a toothpaste, a mouthwash, a poultice, a tea, a sucker, a spray, and like forms, or a mixture thereof.
- In embodiments, the disclosure provides a remineralizing composition comprising: any one of the abovementioned bioactive glass compositions or combinations thereof, and optionally a suitable carrier such as non-aqueous carrier for the remineralizing composition.
- In embodiments, the disclosure provides a remineralizing composition comprising: the abovementioned bioactive glass composition and an optional suitable carrier.
- In embodiments, the disclosure provides a method of treating dentin hypersensitivity or sensitivity comprising:
- contacting a dental surface and any of the abovementioned dental formulations comprising the remineralizing composition.
- In embodiments, the contacting the dental formulation has a higher relative rate of from 50 to 95% of occluding exposed dentin tubules compared to a dental formulation base formula that is free-of the bioactive glass, i.e., without the bioactive glass present.
- In embodiments, contacting the dental formulation can be selected from at least one of: polishing with a paste formula, rinsing with a liquid formula, injecting with a liquid formula, filling a tooth with a composite, e.g., typically made of powdered bioactive glass and acrylic resin, or a combination thereof.
- In embodiments, the dental surface can have at least one of, for example: a dentin surface, a dentin tubule, or a combination thereof.
- In embodiments, the disclosure provides a dental formulation comprising:
- a bioactive glass composition in an effective amount comprising a source of:
- 2 to 70% B2O3,
- 2 to 16% Al2O3,
- 5 to 30% CaO,
- 1 to 6% P2O5,
- 1 to 20% Na2O, and
- 1 to 20% MgO, based on a 100 mol % total of the composition; and a suitable carrier, in an effective amount based on the combined 100 weight % of the bioactive glass and the carrier. The mol % of the source has the equivalent weight percentages of 1 to 60% B2O3, 1 to 60% SiO2, 2 to 20% Al2O3, 5 to 25% CaO, 1 to 10% P2O5, 1 to 20% Na2O, 1 to 25% K2O, and 1 to 15% MgO, based on a 100 wt % total of the composition.
- In embodiments, the dental formulation is free of silica such as a source of SiO2, and free of inorganic potassium salts such as a source of K2O.
- In embodiments, the present disclosure is advantaged in several aspects, including for example: the disclosed borate and borosilicate glass compositions can have a significantly higher rate of occluding of the exposed dentin tubules compared to a 45S5-containing toothpaste, which result(s) demonstrate excellent potential of the disclosed bioactive glass for treating dentin hypersensitivity or dentin sensitivity; the disclosed bioactive glass compositions can be free-of inorganic potassium salts, and the disclosed bioactive glass compositions, and dentin treatment formulations, can be silicate free. Novamin® and Biomin® are silicate-containing bioactive glasses.
- In embodiments, the disclosure provides borate and borosilicate bioactive glass compositions, for example, as listed in Table 1, that can react with mammalian saliva and can release calcium and phosphate to form hydroxycarbonated apatite, or if fluoride ions are present to form fluorapatite (see
FIG. 2 andFIG. 3 ), exhibiting tubule occlusion at the surface by the formation of a smear layer and within dentin tubules, and rebuild, strengthen, and protect tooth structure. There is also deposition of a trace amount of magnesium in the apatite layer (FIG. 3 ). Normal enamel and dentin contain, for example, 0.44 and 1.23 wt % of magnesium, respectively. Magnesium is a co-factor for many enzymes, and stabilizes the structures of DNA and RNA. Magnesium may have stimulatory effects on the tooth development and maintenance. -
TABLE 1 Bioactive glass compositions in mol percent. Glass Example SiO2 B2O3 Al2O3 CaO P2O5 Na2O K2O MgO 1 0 54.6 8 22.1 1.7 6 7.9 7.7 2 9 45 8 22.1 1.7 6 7.9 7.7 3 18 36 8 22.1 1.7 6 7.9 7.7 4 27 27 8 22.1 1.7 6 7.9 7.7 5 36 18 8 22.1 1.7 6 7.9 7.7 6 45 9 8 22.1 1.7 6 7.9 7.7 Comparative 46.1 0 0 26.9 2.6 24.3 7.9 7.7 Ex 7 (45S5 - control) - Fluoride can be incorporated into the glass compositions in a precursor form of, for example, sodium fluoride (NaF), stannous fluoride (SnF2), calcium fluoride (CaF2), and like fluorides or mixtures thereof. The fluoride incorporated glasses can release fluoride and form fluorapatite in an oral fluid. Fluorapatite is more resistant to acid dissolution than hydroxycarbonated apatite.
- The fluoride incorporated glasses can also be added into non-aqueous dentifrice matrix, for example, in combination with another bioactive glass. Fluoride ions are known to aid apatite formation and can stimulate osteoblast division.
- In addition to their re-mineralizing toothpaste effect, the disclosed glass compositions and formulations can also be antimicrobial, which property permits, for example, prevention of dental caries, reduce plaque formation, control gingivitis, suppress breath malodor, and like beneficial effects. The disclosed glass compositions and formulations can also be incorporated in other professionally applied dental products, such as cleaning and polishing pastes, varnishes, re-mineralizing filling materials, and like formulations.
- In embodiments, the disclosure provides a remineralizing composition comprising, for example:
- a bioactive glass composition in an effective amount, e.g., from 0.1 to 10 wt %, comprising a source of:
- 2 to 70% B2O3,
- 1 to 60% SiO2,
- 2 to 16% Al2O3,
- 5 to 30% CaO,
- 1 to 6% P2O5,
- 1 to 20% Na2O,
- 1 to 20% K2O, and
- 1 to 20% MgO, based on a 100 mol % total of the composition, and optionally further comprising a suitable carrier in from 80 to 99.9 wt % to the bioactive glass in from 0.1 to 20 wt % based on the total weight of the composition and carrier. The mol % of the source has the equivalent weight percentages of 1 to 60% B2O3, 1 to 60% SiO2, 2 to 20% Al2O3, 5 to 25% CaO, 1 to 10% P2O5, 1 to 20% Na2O, 1 to 25% K2O, and 1 to 15% MgO, based on a 100 wt % total of the composition.
- Referring to the Figures,
FIG. 1 shows a hypothetical scheme of chemical and physical action of the disclosed bioactive composition. The mechanism of action, although not limited by theory, is believed to include, for example: the bioactive glass particles react with saliva or water to exchange ions, e.g., Na+, K+, and like ions, with H+, and raise the pH (100); calcium and phosphate precipitate as calcium-phosphate (110); and calcium-phosphate, or fluoride if present, crystallize to form hydroxycarbonated apatite or fluorapatite on the dentin surface or within the dentin tubules (120). -
FIGS. 2A to 2F show SEM micrographs of test dentin discs after 1 week treatment: with a base toothpaste formulation (2A, 2B); a 45S5-containing toothpaste (2C, 2D); or an Example 1 containing toothpaste (2E, 2F), and immersion in artificial saliva. There was no occluding of dentin tubules for the base toothpaste treatment. After treatment with the 45S5 containing toothpaste, dentin tubules were partially occluded by crystal-like deposits. After treatment with the Example 1 containing toothpaste, most dentin tubules and dentin surface were occluded by crystal-like deposits. -
FIGS. 3A to 3C show SEM-EDS analysis of dentin deposition after a 1 week treatment with the Example 1 containing toothpaste.FIG. 3A shows the SEM having two points selected (black circles added) for further analysis. SEM-EDS analysis showed the apatite formed on and within the dentin tubules were calcium and phosphate precipitate and small trace of magnesium (seeFIGS. 3B (point 003) and 3C (point 004)). - Each glass composition of Table 1 was separately melted and ground to 1 to 10 microns using, for example, an air jet mill.
- Each ground glass composition of Table 1 was separately formulated into a dental formulation such as listed in Table 2.
- Each dental formulation was evaluated for the ability to occlude dentine discs made of human molars as detailed in Example 9, i.e., the discs having dentin tubules were exposed to the dental formulation and compared to a dental formulation base (control) that was free-of the disclosed bioactive glass.
-
TABLE 2 Base and an exemplary BG* containing toothpaste composition. Base Toothpaste Ingredients (control) (base + BG*) glycerol 69.02 64.02 sodium lauryl sulphate 1.1 1.1 PEG400 20 20 silicon dioxide 8 8 *bioactive glass (BG) — 5 carbopol 940 0.5 0.5 sodium saccharin 0.35 0.35 flavor 1.03 1.03 Total (wt %) 100 100 - Raw materials, equipment, or both, used to produce the compositions of the present disclosure, can introduce certain impurities or components that are not intentionally added, and can be present in the final glass composition. Such materials can be present in the disclosed compositions in minor amounts and are referred to as “tramp materials.”
- Disclosed compositions can comprise the tramp materials, typically in trace amounts. Similarly, “iron-free,” “sodium-free,” “lithium-free,” “zirconium-free,” “alkali earth metal-free,” “heavy metal-free,” or like descriptions, mean that the tramp material was not purposefully added to the composition, but the composition may still comprise iron, sodium, lithium, zirconium, alkali earth metals, or heavy metals, etc., but in approximately tramp or trace amounts.
- Unless otherwise specified, the concentrations of all constituents recited herein are expressed in terms of weight percent (wt %).
- The following Examples demonstrate making, use, and analysis of the disclosed compositions, formulations, and methods in accordance with the above general procedures.
- Glass 1
- The composition of Example 1 in Table 1 was prepared as follows: The source batch materials in the indicated amounts, including silicon dioxide, boric acid, alumina, sodium oxide, potassium oxide, limestone, magnesium oxide, and calcium phosphate, were individually combined. The batch source materials were vigorously mixed in a plastic jar using a Turbular mixer. Then they were transferred to a platinum crucible with an internal volume of approximately 650 cc. The crucible was then loaded into an annealing furnace to calcine the batch at 250° C. for 24 hr. The calcined batches were then melted at 1100 to 1300° C. for 6 hr and then the glass melt was poured on a steel plate, and annealed at 400 to 500° C.
- Glasses 2 through 6 were likewise prepared as in Example 1 with the exception that the composition or amount used in the batch was different and as listed in Table 1.
- Comparative Glass 7
- The composition of Comparative Example 7 in Table 1 was prepared as in Example 1 with the exception that: there is no boric acid or alumina batched in the comparative glass, see for example US 20140186274, which mentions a non-aqueous base composition in combination with a bioactive glass.
- Dental Formulation
- The dental formulations of Table 2 were prepared as follows: Glycerol and PEG 400 were added to the glass composition first, then the remaining ingredients of the formulation were separately added and thoroughly mixed with a spatula.
- Evaluation of Dental Formulation
- The dental formulations of Table 2 were evaluated as follows: Human molars were lawfully obtained from bforbones (bforbones.com). Dentine discs having a thickness of 1 mm were cut perpendicularly to the long axis of the tooth above the cemento-enamel junction using a Buehler low-speed water cooled diamond saw. A smear layer was created on both sides of the dentine discs by sanding 30 seconds using 500-grit sanding paper. The smear was subsequently removed by treating with 6% citric acid for 3 mins, then rinsed with water, and dried at 37° C. The dentine discs were randomly divided into control or experiment groups, each containing at least 3 specimens, which received either a non-aqueous toothpaste base formulation or a toothpaste containing 5% of 45S5; and the toothpaste containing a disclosed glass composition, as listed in Tables 1 and 2. The toothpaste and a powered tooth brush were used to brush against both sides of the dentin discs for 1 min per side. The specimens were then rinsed with distilled water to remove visible traces of toothpaste, and then stored in artificial saliva (1.5 mM CaCl2), 0.9 mM KH2PO4, 130 mM KCl, and 20 mM HEPES with pH 7.4). The procedure of brushing, rinsing, and storing each specimen in artificial saliva was repeated twice a day for 7 days, then the specimens were dried at 37° C. for 16 hrs and stored at RT before SEM.
- The disclosure has been described with reference to various specific embodiments and techniques. However, many variations and modifications are possible while remaining within the scope of the disclosure.
Claims (21)
1. A dental formulation comprising:
a bioactive glass composition in an effective amount comprising a source of:
2 to 70% B2O3,
2 to 16% Al2O3,
5 to 30% CaO,
1 to 6% P2O5,
1 to 20% Na2O, and
1 to 20% MgO, based on a 100 mol % total of the composition; and
a carrier, in an effective amount based on the combined weight of the bioactive glass and the carrier.
2. The dental formulation of claim 1 , wherein:
the bioactive glass further comprises a source of from 5 to 50% SiO2, based on a 100 mol % total of the composition, and
the carrier comprises a source of silica of from 1 to 25 wt % SiO2 by super addition to the bioactive glass.
3. The dental formulation of claim 1 , wherein the bioactive glass further comprises a source of from 1 to 20% K2O.
4. The dental formulation of claim 1 , wherein the bioactive glass is essentially free of silica as a source of SiO2, and free of inorganic potassium salts as a source of K2O.
5. The dental formulation of claim 1 , further comprising a source of fluoride ion in an amount of from 1 to 25 mol % by super addition to the composition.
6. The dental formulation of claim 5 , wherein the source of fluoride ion is selected from NaF, SnF2, CaF2, or a combination thereof.
7. The dental formulation of claim 1 , wherein the bioactive glass is essentially free of a source of fluoride ion.
8. The dental formulation of claim 1 , wherein the bioactive glass composition in an effective amount is from 0.1 to 10 wt %, and the suitable carrier in an effective amount is from 90 to 99.9 wt %.
9. The dental formulation of claim 1 , wherein the carrier comprises at least one of an abrasive, a humectant, a flavorant, a colorant, an antibacterial agent, a surfactant, a whitening agent, a binder, or a mixture thereof.
10. The dental formulation of claim 1 , wherein the suitable carrier comprises one or more forms selected from: a gum, a paste, a powder, a toothpaste, a mouthwash, a poultice, a tea, a sucker, a spray, or a mixture thereof.
11. The dental formulation of claim 1 , wherein the bioactive glass composition in an effective amount comprising a source of:
6 to 10% Al2O3,
15 to 25% CaO,
1.5 to 2% P2O5,
4 to 8% Na2O,
6 to 10% K2O, and
6 to 10% MgO, based on a 100 mol % total of the composition.
12. The dental formulation of claim 1 , wherein the bioactive glass composition comprises:
40 to 60% B2O3, and
0 to 10% SiO2, based on a 100 mol % total of the composition.
13. The dental formulation of claim 1 , wherein the bioactive glass composition comprises:
20 to 40% B2O3, and
10 to 30% SiO2, based on a 100 mol % total of the composition.
14. The dental formulation of claim 1 , wherein the bioactive glass composition comprises:
5 to 20% B2O3, and
30 to 50% SiO2, based on a 100 mol % total of the composition.
15. A method of treating dental hypersensitivity, comprising:
reacting a borate or borosilicate glass composition with mammalian saliva to form hydroxycarbonated apatite or fluorapatite on a dentin surface, a dentin tubule, or combination thereof.
16. The method of claim 15 , wherein the borate or borosilicate glass composition comprises:
2 to 70% B2O3,
2 to 16% Al2O3,
5 to 30% CaO,
1 to 6% P2O5,
1 to 20% Na2O, and
1 to 20% MgO, based on a 100 mol % total of the composition.
17. The method of claim 16 , wherein the borate or borosilicate glass composition in an effective amount comprising a source of:
6 to 10% Al2O3,
15 to 25% CaO,
1.5 to 2% P2O5,
4 to 8% Na2O,
6 to 10% K2O, and
6 to 10% MgO, based on a 100 mol % total of the composition.
18. The method of claim 16 , wherein the borate or borosilicate glass composition comprises:
40 to 60% B2O3, and
0 to 10% SiO2, based on a 100 mol % total of the composition.
19. The method of claim 16 , wherein the borate or borosilicate glass composition comprises:
20 to 40% B2O3, and
10 to 30% SiO2, based on a 100 mol % total of the composition.
20. The method of claim 16 , wherein the borate or borosilicate glass composition comprises:
5 to 20% B2O3, and
30 to 50% SiO2, based on a 100 mol % total of the composition.
21. The method of claim 16 , wherein the borate or borosilicate glass composition comprises:
a source of fluoride ion in an amount of from 1 to 25 mol % by super addition to the composition.
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Family Cites Families (151)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2532386A (en) | 1949-09-27 | 1950-12-05 | Corning Glass Works | Colored phosphate glass |
NL232500A (en) | 1957-10-22 | |||
US2987339A (en) | 1960-01-27 | 1961-06-06 | Cullen Friestedt Company | Articulated lifter |
NL279296A (en) | 1961-06-12 | |||
US3323888A (en) | 1964-03-17 | 1967-06-06 | Cataphote Corp | Method for manufacturing glass beads |
US3778335A (en) | 1971-09-02 | 1973-12-11 | Corning Glass Works | Sodium aluminosilicate glass article strengthened by a surface compressive stress layer |
US4126437A (en) | 1976-12-02 | 1978-11-21 | Xerox Corporation | Magnetic glass carrier materials |
US4083727A (en) | 1977-01-07 | 1978-04-11 | Corning Glass Works | Glass-ceramics with magnetic surface films |
US4084972A (en) | 1977-01-07 | 1978-04-18 | Corning Glass Works | Glass-ceramics with metallic iron surfaces |
US4140645A (en) | 1978-06-12 | 1979-02-20 | Corning Glass Works | Glasses and glass-ceramics suitable for induction heating |
GB2035290B (en) | 1978-11-24 | 1982-11-10 | Standard Telephones Cables Ltd | Glass compositions and cements incorporating such compositions |
US4233169A (en) | 1979-04-13 | 1980-11-11 | Corning Glass Works | Porous magnetic glass structure |
US4323056A (en) | 1980-05-19 | 1982-04-06 | Corning Glass Works | Radio frequency induced hyperthermia for tumor therapy |
US4391646A (en) | 1982-02-25 | 1983-07-05 | Minnesota Mining And Manufacturing Company | Glass bubbles of increased collapse strength |
JPS60210546A (en) | 1984-04-02 | 1985-10-23 | Ngk Spark Plug Co Ltd | Crystallized glass for crown |
GB8612387D0 (en) | 1986-05-21 | 1986-07-16 | Univ Sheffield | Glass ceramics |
KR920001501B1 (en) | 1987-09-01 | 1992-02-15 | 가부시기가이샤 히다찌세이사구쇼 | Black matrix color picture tube and the method of the same |
US4889707A (en) | 1988-01-29 | 1989-12-26 | The Curators Of The University Of Missouri | Composition and method for radiation synovectomy of arthritic joints |
US5217928A (en) | 1988-08-24 | 1993-06-08 | Potters Industries, Inc. | Hollow glass spheres |
US5196381A (en) | 1990-01-16 | 1993-03-23 | E. I. Du Pont De Nemours And Company | Metaphosphate glass composition |
IT1240938B (en) | 1990-02-08 | 1993-12-27 | S.E.I.P.I. Societa' Esportazione Importazione Prodotti Industriali | BIOACTIVE GLASS COMPOSITION FOR BONE IMPLANTS AND PRODUCTS OBTAINED WITH SUCH A COMPOSITION OR THAT INCLUDE IT |
US5153070A (en) | 1990-08-01 | 1992-10-06 | Corning Incorporated | Coated refractory article and method |
US5876452A (en) | 1992-02-14 | 1999-03-02 | Board Of Regents, University Of Texas System | Biodegradable implant |
AU668878B2 (en) | 1992-08-20 | 1996-05-23 | Isover Saint-Gobain | Method for producing mineral wool, and mineral wool produced thereby |
US5648124A (en) | 1993-07-09 | 1997-07-15 | Seradyn, Inc. | Process for preparing magnetically responsive microparticles |
US5849816A (en) | 1994-08-01 | 1998-12-15 | Leonard Pearlstein | Method of making high performance superabsorbent material |
DE4428851C2 (en) | 1994-08-04 | 2000-05-04 | Diagnostikforschung Inst | Nanoparticles containing iron, their production and application in diagnostics and therapy |
US6254981B1 (en) | 1995-11-02 | 2001-07-03 | Minnesota Mining & Manufacturing Company | Fused glassy particulates obtained by flame fusion |
PT944556E (en) | 1995-11-14 | 2002-02-28 | Corning Inc | OPALINE GLASSES NOT CRYSTALLINE, SEPARATED BY PHASES |
US5674790A (en) | 1995-12-15 | 1997-10-07 | Corning Incorporated | Strengthening glass by ion exchange |
PT877716E (en) * | 1996-01-29 | 2005-02-28 | Usbiomaterials Corp | BIOACTIVE GLASS COMPOSITIONS FOR USE IN THE TREATMENT OF DENTAL STRUCTURES |
US5735942A (en) | 1996-02-07 | 1998-04-07 | Usbiomaterials Corporation | Compositions containing bioactive glass and their use in treating tooth hypersensitivity |
US6323549B1 (en) | 1996-08-29 | 2001-11-27 | L. Pierre deRochemont | Ceramic composite wiring structures for semiconductor devices and method of manufacture |
US6756060B1 (en) | 1996-09-19 | 2004-06-29 | Usbiomaterials Corp. | Anti-inflammatory and antimicrobial uses for bioactive glass compositions |
US5834008A (en) | 1996-09-19 | 1998-11-10 | U.S. Biomaterials Corp. | Composition and method for acceleration of wound and burn healing |
EP0930874A2 (en) | 1996-10-09 | 1999-07-28 | Takeda Chemical Industries, Ltd. | A method for producing a microparticle |
WO1998047830A1 (en) | 1997-04-18 | 1998-10-29 | Minnesota Mining And Manufacturing Company | Transparent beads and their production method |
US6280863B1 (en) | 1997-06-12 | 2001-08-28 | Ivoclar Ag | Translucent apatite glass ceramic |
US6034014A (en) | 1997-08-04 | 2000-03-07 | Owens Corning Fiberglas Technology, Inc. | Glass fiber composition |
GB9811661D0 (en) | 1998-06-01 | 1998-07-29 | Giltech Ltd | Compositions |
US6802894B2 (en) | 1998-12-11 | 2004-10-12 | Jeneric/Pentron Incorporated | Lithium disilicate glass-ceramics |
CA2343223C (en) | 1998-09-10 | 2014-08-12 | Usbiomaterials Corporation | Anti-inflammatory and antimicrobial uses for bioactive glass compositions |
US6214471B1 (en) | 1998-11-03 | 2001-04-10 | Corning Incorporated | Glasses compatible with aluminum |
JP2001010843A (en) | 1999-04-30 | 2001-01-16 | Ohara Inc | Crystalline low-melting glass and sealing composition |
IT1313655B1 (en) | 1999-09-30 | 2002-09-09 | Techint Spa | GLASS FIBER COMPOSITION. |
US6328990B1 (en) | 1999-11-12 | 2001-12-11 | The Trustees Of The University Of Pennsylvania | Bioactive, degradable composite for tissue engineering |
JP2001247333A (en) | 1999-12-28 | 2001-09-11 | Ishizuka Glass Co Ltd | Glass composition for imparting antimicrobial properties, antimicrobial fiber, antimicrobial spun yarn and antimicrobial fabric |
US6306423B1 (en) | 2000-06-02 | 2001-10-23 | Allergan Sales, Inc. | Neurotoxin implant |
JP4323707B2 (en) | 2000-10-25 | 2009-09-02 | 富士通マイクロエレクトロニクス株式会社 | Flash memory defect management method |
US7597900B2 (en) | 2001-03-27 | 2009-10-06 | Schott Ag | Tissue abrasives |
DE10141117A1 (en) | 2001-08-22 | 2003-03-13 | Schott Glas | Antimicrobial silicate glass and its use |
ATE332879T1 (en) | 2001-08-22 | 2006-08-15 | Schott Ag | ANTIMICROBIAL, ANTI-INFLAMMATORY, WOUND-HEALING GLASS POWDER AND USE THEREOF |
US7166549B2 (en) | 2001-08-22 | 2007-01-23 | Schott Ag | Antimicrobial, anti-inflammatory, wound-healing and disinfecting glass and use thereof |
AU2002358123A1 (en) * | 2001-12-12 | 2003-06-23 | Schott Glas | Use of an antimicrobial glass ceramic for dental care and oral hygiene |
WO2004084851A2 (en) | 2003-03-24 | 2004-10-07 | Exa Sa | A treatment composition |
DE10203629A1 (en) | 2002-01-30 | 2003-07-31 | Ulrich Zimmermann | Device and method for producing microcapsules and improved microcapsule |
EP1567111B1 (en) | 2002-11-15 | 2011-08-24 | Color Access, Inc. | Transparent concealing cosmetic compositions |
US20050118236A1 (en) | 2002-12-03 | 2005-06-02 | Gentis Inc. | Bioactive, resorbable scaffolds for tissue engineering |
US8080490B2 (en) | 2003-02-25 | 2011-12-20 | Schott Ag | Antimicrobial phosphate glass |
JP4293806B2 (en) | 2003-02-28 | 2009-07-08 | 石塚硝子株式会社 | Antibacterial imparting glass composition and antibacterial polymer composite material using the same |
GB0310673D0 (en) | 2003-05-09 | 2003-06-11 | Givaudan Sa | Alginate matrix particles |
JP2004359754A (en) | 2003-06-03 | 2004-12-24 | Ishizuka Glass Co Ltd | Antimicrobial resin composition and its molding |
US8444756B2 (en) | 2003-08-07 | 2013-05-21 | Ivoclar Vivadent Ag | Lithium silicate materials |
DE10336913C9 (en) | 2003-08-07 | 2019-02-21 | Ivoclar Vivadent Ag | Use of a lithium silicate material |
HU227595B1 (en) | 2003-08-07 | 2011-09-28 | Mta | Metal complexes of polygalacturonic acid and their production |
FR2867075B1 (en) | 2004-03-03 | 2006-07-14 | Ethypharm Sa | PROCESS FOR PREPARING CALIBRATED BIODEGRADABLE MICROSPHERES |
DE102004011520A1 (en) | 2004-03-08 | 2005-10-06 | Schott Ag | Antimicrobial refractive index adapted phosphate glass |
DE102004013455B3 (en) | 2004-03-18 | 2005-09-08 | Ivoclar Vivadent Ag | Apatite glass-ceramic useful for making dental materials comprises a glass phase and a phosphate- and fluorine-free silicate-based oxyapatite phase |
US7771742B2 (en) | 2004-04-30 | 2010-08-10 | Allergan, Inc. | Sustained release intraocular implants containing tyrosine kinase inhibitors and related methods |
DE102004026432A1 (en) * | 2004-05-29 | 2005-12-22 | Schott Ag | Glass compositions as antimicrobial additive for dental materials and their use |
FR2873683B1 (en) | 2004-07-27 | 2007-06-15 | Inst Nat Sciences Appliq | POROUS BIOVERRE AND PROCESS FOR PREPARING THE SAME |
DE202004014053U1 (en) | 2004-09-07 | 2004-11-11 | Deep Colours! Gmbh | tattoo |
US20060127427A1 (en) | 2004-12-15 | 2006-06-15 | Vernice Joseph J | Surface coated abrasive material for cosmetic products |
DE102005001078A1 (en) | 2005-01-08 | 2006-07-20 | Schott Ag | Glass powder, in particular biologically active glass powder and process for the production of glass powder, in particular biologically active glass powder |
US9326995B2 (en) | 2005-04-04 | 2016-05-03 | The Regents Of The University Of California | Oxides for wound healing and body repair |
US7989065B2 (en) | 2005-05-20 | 2011-08-02 | Seradyn, Inc. | Magnetically-responsive microparticles with improved response times |
JP4226574B2 (en) | 2005-06-27 | 2009-02-18 | 株式会社ノリタケカンパニーリミテド | Glass composition having acid resistance |
JP2007039269A (en) | 2005-08-02 | 2007-02-15 | Asahi Glass Co Ltd | Glass for covering electrode, and plasma display device |
DE102005038070A1 (en) | 2005-08-10 | 2007-03-15 | Henkel Kgaa | Detergents and cleaners with well soluble capsules |
WO2007022264A2 (en) | 2005-08-15 | 2007-02-22 | The Regents Of The University Of California | Oxides for wound healing and body repair |
KR100792456B1 (en) | 2006-02-14 | 2008-01-10 | 엘지전자 주식회사 | Addressing apparatus of display panel and method thereof |
KR101024417B1 (en) | 2006-06-07 | 2011-03-23 | 가부시키가이샤 피노레 | Mixed antibacterial glass |
GB0612028D0 (en) | 2006-06-16 | 2006-07-26 | Imp Innovations Ltd | Bioactive glass |
US20090324668A1 (en) | 2006-06-28 | 2009-12-31 | Ilkka Kangasniemi | Implant, its uses and methods for making it |
EP2032182A2 (en) | 2006-06-28 | 2009-03-11 | Vivoxid Oy | Implant containing a source of oxygen |
US8288344B2 (en) | 2007-03-15 | 2012-10-16 | Musculoskeletal Transplant Foundation | Ceramic composition for filling bone defects |
DK2217363T3 (en) | 2007-11-14 | 2019-01-21 | Univ Queensland | APPLICATION OF A DEVICE AND PROCEDURE FOR MANUFACTURING MICROPARTICLES |
US9241879B2 (en) | 2008-04-11 | 2016-01-26 | James R. Glidewell Dental Ceramics, Inc. | Lithium silicate glass ceramic for fabrication of dental appliances |
CN101596326A (en) | 2008-06-06 | 2009-12-09 | 华东理工大学 | A kind of borate biological microcrystalline glass and its production and application |
CN101407373B (en) | 2008-11-18 | 2011-12-28 | 湖北顶盛科技发展有限公司 | Strontium-reinforced bioactivity glass, production method there and use in tooth-cleaning products |
AR076179A1 (en) * | 2009-04-01 | 2011-05-26 | Colgate Palmolive Co | NON-WATERPROOF DIFFERENT COMPOSITION WITH BIOACCEPTABLE AND BIOACTIVE GLASS AND METHODS OF USE AND MANUFACTURING OF THE SAME |
EP2243749B1 (en) | 2009-04-23 | 2015-04-08 | PURAC Biochem BV | Resorbable and biocompatible fibre glass compositions and their uses |
CN101704632B (en) | 2009-11-30 | 2012-08-29 | 中国建材国际工程有限公司 | Preparation method of high-strength low-density hollow glass bead |
US20110152057A1 (en) | 2009-12-21 | 2011-06-23 | Gang Qi | Hollow microspheres |
US8173154B2 (en) | 2010-01-06 | 2012-05-08 | The Curators Of The University Of Missouri | Boron trioxide glass-based fibers and particles in dressings, sutures, surgical glue, and other wound care compositions |
EP2386525A1 (en) | 2010-05-13 | 2011-11-16 | Universitat Politècnica de Catalunya | Nanostructured material comprising a biocompatible calcium phosphate glass, sol-gel process for its preparation and medical use thereof |
US20160145567A1 (en) | 2010-05-27 | 2016-05-26 | Corning Incorporated | Cell culture article and methods thereof |
GB201010758D0 (en) | 2010-06-25 | 2010-08-11 | Queen Mary & Westfield College | Bioactive glass composition |
DE102010034083A1 (en) | 2010-08-12 | 2012-02-16 | Süd-Chemie AG | Magnetic glass particles for use in biogas plants, fermentation and separation processes |
US8883663B2 (en) | 2010-11-30 | 2014-11-11 | Corning Incorporated | Fusion formed and ion exchanged glass-ceramics |
KR101262121B1 (en) | 2010-12-27 | 2013-05-14 | 주식회사 하스 | Manufacturing method of high strength glass ceramics for teeth |
US20140079642A1 (en) | 2011-01-24 | 2014-03-20 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd | Nanoparticles based for dermal and systemic delivery of drugs |
PT105617A (en) | 2011-04-05 | 2012-10-08 | Univ Aveiro | COMPOSITION OF BIOACTIVE GLASS, ITS USE AND RESPECTIVE METHOD OF OBTAINING |
WO2012177617A1 (en) | 2011-06-20 | 2012-12-27 | The Procter & Gamble Company | Liquid cleaning and/or cleansing composition |
US20120321567A1 (en) | 2011-06-20 | 2012-12-20 | Denis Alfred Gonzales | Liquid cleaning and/or cleansing composition |
GB201113754D0 (en) | 2011-08-09 | 2011-09-21 | Glaxo Group Ltd | Composition |
US20140000891A1 (en) | 2012-06-21 | 2014-01-02 | Self-Suspending Proppant Llc | Self-suspending proppants for hydraulic fracturing |
US9232989B2 (en) | 2011-10-14 | 2016-01-12 | Ivoclar Vivadent Ag | Lithium silicate glass ceramic and lithium silicate glass comprising a divalent metal oxide |
DE112012004261A5 (en) | 2011-10-14 | 2014-08-28 | Ivoclar Vivadent Ag | Lithium silicate glass-ceramic and glass with monovalent metal oxide |
CN102430149A (en) | 2011-11-18 | 2012-05-02 | 华东理工大学 | Phosphate glass fiber/chitosan composite material |
WO2013107653A2 (en) | 2012-01-20 | 2013-07-25 | Straumann Holding Ag | Prosthetic element |
CN102526797B (en) | 2012-02-08 | 2013-10-30 | 同济大学 | Preparation method of high-strength biological glass bone bracket with regular-hole distribution |
KR20130112433A (en) | 2012-04-04 | 2013-10-14 | 주식회사 케이씨씨 | A composition for preparing glass wool and a biosoluble glass wool prepared therefrom |
WO2013164256A1 (en) | 2012-05-04 | 2013-11-07 | Ivoclar Vivadent Ag | Lithium disilicate-apatite glass-ceramic |
EP2668967B1 (en) | 2012-05-30 | 2014-05-14 | Skulle Implants OY | An implant |
IN2015DN01369A (en) | 2012-07-19 | 2015-07-03 | Relypsa Inc | |
US20140026916A1 (en) | 2012-07-25 | 2014-01-30 | College Of William And Mary | Method for Reducing Marine Pollution Using Polyhydroxyalkanoate Microbeads |
ES2688381T3 (en) | 2012-09-28 | 2018-11-02 | Stelo Technologies | Methods for making silver nanoparticles and their applications |
EP2931376B1 (en) | 2012-12-17 | 2017-07-26 | Unilever N.V. | Topical composition |
US20140212469A1 (en) | 2013-01-28 | 2014-07-31 | Missouri University Of Science And Technology | Surface functional bioactive glass scaffold for bone regeneration |
US20140219941A1 (en) | 2013-02-06 | 2014-08-07 | U.S. Cosmetic Corporation | Cosmetic powder coated with alginic acid and methods of making the same |
CA2902459A1 (en) | 2013-03-14 | 2014-10-02 | Novabone Products, Llc | Compositions and methods for manufacturing sol-gel derived bioactive borophosphate glasses for medical applicatons |
WO2014150224A1 (en) | 2013-03-14 | 2014-09-25 | Novabone Products, Llc | Sodium containing sol-gel derived bioactive glasses and uses thereof including hemostasis |
EP2792345B1 (en) | 2013-04-15 | 2019-10-09 | Ivoclar Vivadent AG | Lithium silicate glass ceramic and glass with caesium oxide content |
CN103172263B (en) | 2013-04-16 | 2015-03-18 | 中国地质科学院 | Biological microcrystalline glass prepared by utilizing phosphate tailings and preparation method thereof |
US9359244B2 (en) | 2013-05-21 | 2016-06-07 | Colorado School Of Mines | Alumina-rich glasses and methods for making the same |
US9701573B2 (en) | 2013-09-06 | 2017-07-11 | Corning Incorporated | High strength glass-ceramics having lithium disilicate and beta-spodumene structures |
US10117668B2 (en) | 2013-10-08 | 2018-11-06 | The Spectranetics Corporation | Balloon catheter with non-deployable stent having improved stability |
KR101524482B1 (en) | 2013-10-14 | 2015-06-02 | 주식회사 하스 | Glass-ceramics or Lithium silicate glass for Zirconia overlaying materials and preparation method thereof |
ES2891275T3 (en) | 2013-11-05 | 2022-01-26 | Ivoclar Vivadent Ag | Lithium-apatite disilicate glass-ceramic with transition metal oxide |
WO2015123049A1 (en) | 2014-02-17 | 2015-08-20 | The Procter & Gamble Company | Skin cleansing compositions comprising biodegradable abrasive particles |
US9622483B2 (en) | 2014-02-19 | 2017-04-18 | Corning Incorporated | Antimicrobial glass compositions, glasses and polymeric articles incorporating the same |
US9878940B2 (en) | 2014-02-21 | 2018-01-30 | Corning Incorporated | Low crystallinity glass-ceramics |
CN103979796B (en) | 2014-05-19 | 2016-08-24 | 白银金奇化工科技有限公司 | A kind of high intensity hollow glass micropearl and preparation method thereof |
US20150350210A1 (en) | 2014-06-02 | 2015-12-03 | Antique Books Inc. | Advanced proofs of knowledge for the web |
US10507263B2 (en) | 2014-06-09 | 2019-12-17 | The Royal Institution For The Advancement Of Learning/Mcgill University | Borate-glass biomaterials |
US20170128174A1 (en) | 2014-06-23 | 2017-05-11 | 3M Innovative Properties Company | Process for producing a sintered lithium disilicate glass ceramic dental restoration and kit of parts |
CN104108883B (en) | 2014-08-11 | 2019-03-08 | 中国地质大学(北京) | A kind of high intensity lithium bisilicate glass ceramics and preparation method thereof |
KR101648175B1 (en) | 2014-08-29 | 2016-08-16 | 주식회사 하스 | Cristobalite crystal-containing lithium disilicate glass-ceramics with high strength and esthetics and preparation method thereof |
US10239780B2 (en) | 2014-10-08 | 2019-03-26 | Corning Incorporated | High strength glass-ceramics having petalite and lithium silicate structures |
US10201633B2 (en) | 2014-12-05 | 2019-02-12 | Augusta University Research Institute, Inc. | Glass composites for tissue augmentation, biomedical and cosmetic applications |
DE102015108171A1 (en) | 2015-05-22 | 2016-11-24 | Degudent Gmbh | Process for increasing the strength of shaped bodies consisting of lithium silicate glass-ceramic |
CN105236745A (en) | 2015-08-27 | 2016-01-13 | 陕西科技大学 | Ferromagnetic Fe3O4 nano micro-crystal glass and preparation method thereof |
CN105819697B (en) | 2016-03-29 | 2019-03-01 | 中材科技股份有限公司 | A kind of bio-compatible phosphate base continuous glass fibre and fabric prepared therefrom |
US10751367B2 (en) | 2016-05-27 | 2020-08-25 | Corning Incorporated | Bioactive glass microspheres |
US10647962B2 (en) | 2016-05-27 | 2020-05-12 | Corning Incorporated | Bioactive aluminoborate glasses |
US10676713B2 (en) | 2016-05-27 | 2020-06-09 | Corning Incorporated | Bioactive borophosphate glasses |
US20170340527A1 (en) | 2016-05-27 | 2017-11-30 | Corning Incorporated | Biodegradable microbeads |
US10059621B2 (en) | 2016-05-27 | 2018-08-28 | Corning Incorporated | Magnetizable glass ceramic composition and methods thereof |
US20170342383A1 (en) | 2016-05-27 | 2017-11-30 | Corning Incorporated | Lithium disilicate glass-ceramic compositions and methods thereof |
US10624994B2 (en) * | 2017-08-30 | 2020-04-21 | King Abdulaziz University | Borate bioactive glass and methods of use for dentin and enamel restoration |
-
2018
- 2018-11-27 WO PCT/US2018/062671 patent/WO2019108556A1/en unknown
- 2018-11-27 EP EP18822555.1A patent/EP3717030A1/en active Pending
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