KR101928321B1 - 프로게스틴/에스트라디올 경피 젤 - Google Patents

프로게스틴/에스트라디올 경피 젤 Download PDF

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Publication number
KR101928321B1
KR101928321B1 KR1020187019976A KR20187019976A KR101928321B1 KR 101928321 B1 KR101928321 B1 KR 101928321B1 KR 1020187019976 A KR1020187019976 A KR 1020187019976A KR 20187019976 A KR20187019976 A KR 20187019976A KR 101928321 B1 KR101928321 B1 KR 101928321B1
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South Korea
Prior art keywords
estradiol
progestin
formulation
transdermal
female
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Expired - Fee Related
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KR1020187019976A
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English (en)
Korean (ko)
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KR20180084149A (ko
Inventor
레진 시트룩-웨어
다리오 노르베르토 라몬 카라라
아르노 그르니에
Original Assignee
더 파퓰레이션 카운실 인코포레이티드
안타레스 파르마 아이피엘 에이쥐
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Application filed by 더 파퓰레이션 카운실 인코포레이티드, 안타레스 파르마 아이피엘 에이쥐 filed Critical 더 파퓰레이션 카운실 인코포레이티드
Publication of KR20180084149A publication Critical patent/KR20180084149A/ko
Application granted granted Critical
Publication of KR101928321B1 publication Critical patent/KR101928321B1/ko
Assigned to 더 파퓰레이션 카운실 인코포레이티드 reassignment 더 파퓰레이션 카운실 인코포레이티드 권리지분의 전부이전등록 Assignors: 안타레스 파르마 아이피엘 에이쥐
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/18—Feminine contraceptives

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Dermatology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
KR1020187019976A 2009-12-17 2010-12-17 프로게스틴/에스트라디올 경피 젤 Expired - Fee Related KR101928321B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US28751409P 2009-12-17 2009-12-17
US61/287,514 2009-12-17
PCT/US2010/060941 WO2011084668A1 (en) 2009-12-17 2010-12-17 Nestorone®/estradiol transdermal gel

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
KR1020127018352A Division KR20120107492A (ko) 2009-12-17 2010-12-17 프로게스틴/에스트라디올 경피 젤

Publications (2)

Publication Number Publication Date
KR20180084149A KR20180084149A (ko) 2018-07-24
KR101928321B1 true KR101928321B1 (ko) 2018-12-12

Family

ID=43640394

Family Applications (2)

Application Number Title Priority Date Filing Date
KR1020187019976A Expired - Fee Related KR101928321B1 (ko) 2009-12-17 2010-12-17 프로게스틴/에스트라디올 경피 젤
KR1020127018352A Ceased KR20120107492A (ko) 2009-12-17 2010-12-17 프로게스틴/에스트라디올 경피 젤

Family Applications After (1)

Application Number Title Priority Date Filing Date
KR1020127018352A Ceased KR20120107492A (ko) 2009-12-17 2010-12-17 프로게스틴/에스트라디올 경피 젤

Country Status (14)

Country Link
US (1) US9682087B2 (https=)
EP (1) EP2512486B1 (https=)
JP (1) JP6082249B2 (https=)
KR (2) KR101928321B1 (https=)
CN (1) CN102753180A (https=)
AU (1) AU2010339867B2 (https=)
BR (1) BR112012014059B1 (https=)
CA (1) CA2782075C (https=)
ES (1) ES2641613T3 (https=)
IN (1) IN2012DN04867A (https=)
MX (1) MX363536B (https=)
NZ (1) NZ600907A (https=)
WO (1) WO2011084668A1 (https=)
ZA (1) ZA201204267B (https=)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR112014012444B1 (pt) 2011-11-23 2021-12-14 Therapeuticsmd, Inc Composição farmacêutica compreendendo estradiol solubilizado, progesterona e um agente de solubilização, bem como usos desta para tratar um sintoma relacionado à menopausa em uma mulher
US9301920B2 (en) 2012-06-18 2016-04-05 Therapeuticsmd, Inc. Natural combination hormone replacement formulations and therapies
CN102657661A (zh) * 2012-04-15 2012-09-12 温州医学院 Nestorone在制备治疗阿尔茨海默病的药物用途
US10806740B2 (en) 2012-06-18 2020-10-20 Therapeuticsmd, Inc. Natural combination hormone replacement formulations and therapies
US20130338122A1 (en) 2012-06-18 2013-12-19 Therapeuticsmd, Inc. Transdermal hormone replacement therapies
US20150196640A1 (en) 2012-06-18 2015-07-16 Therapeuticsmd, Inc. Progesterone formulations having a desirable pk profile
US10806697B2 (en) 2012-12-21 2020-10-20 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US10568891B2 (en) 2012-12-21 2020-02-25 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US11246875B2 (en) 2012-12-21 2022-02-15 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US9180091B2 (en) 2012-12-21 2015-11-10 Therapeuticsmd, Inc. Soluble estradiol capsule for vaginal insertion
US10471072B2 (en) 2012-12-21 2019-11-12 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US10537581B2 (en) 2012-12-21 2020-01-21 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US11266661B2 (en) 2012-12-21 2022-03-08 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US9433680B2 (en) 2013-01-31 2016-09-06 Merz Pharmaceuticals, Llc Topical compositions and methods for making and using same
US9446131B2 (en) 2013-01-31 2016-09-20 Merz Pharmaceuticals, Llc Topical compositions and methods for making and using same
US9452173B2 (en) 2013-01-31 2016-09-27 Merz Pharmaceuticals, Llc Topical compositions and methods for making and using same
US8778365B1 (en) 2013-01-31 2014-07-15 Merz Pharmaceuticals, Llc Topical compositions and methods for making and using same
RU2016143081A (ru) 2014-05-22 2018-06-26 Терапьютиксмд, Инк. Натуральные комбинированные гормонозаместительные составы и терапии
RU2016141135A (ru) 2014-07-29 2018-08-28 Терапьютиксмд, Инк. Трансдермальный крем
US10328087B2 (en) 2015-07-23 2019-06-25 Therapeuticsmd, Inc. Formulations for solubilizing hormones
RU2648470C2 (ru) * 2016-03-03 2018-03-26 Государственное бюджетное образовательное учреждение высшего профессионального образования "Уральский государственный медицинский университет Министерства здравоохранения Российской Федерации" (ГБОУ ВПО УГМУ Минздрава России) Способ оптимизации лечения женщин кардиотропной терапией и заместительной гормональной терапией при эстрогенодефиците с артериальной гипертензией в позднем репродуктивном периоде
US10286077B2 (en) 2016-04-01 2019-05-14 Therapeuticsmd, Inc. Steroid hormone compositions in medium chain oils
US9931349B2 (en) 2016-04-01 2018-04-03 Therapeuticsmd, Inc. Steroid hormone pharmaceutical composition
US20240358655A1 (en) * 2021-03-30 2024-10-31 Viatris Inc. Transdermal Systems having low dose estrogen and methods of making and use

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1093816A3 (en) 1990-06-01 2003-10-22 The Population Council, Inc. Use of ST1435 in hormonal therapy by transdermal application
US5198223A (en) * 1990-10-29 1993-03-30 Alza Corporation Transdermal formulations, methods and devices
US5122382A (en) * 1990-10-29 1992-06-16 Alza Corporation Transdermal contraceptive formulations, methods and devices
JPH04342531A (ja) 1991-05-21 1992-11-30 Sekisui Chem Co Ltd 経皮吸収製剤
US7198801B2 (en) * 2000-08-03 2007-04-03 Antares Pharma Ipl Ag Formulations for transdermal or transmucosal application
WO2011049948A2 (en) 2009-10-19 2011-04-28 The Population Council, Inc. Neuroprotection and myelin repair using nestorone®

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
Antares Pharma and Population Council Announce Preliminary Positive Phase 2 Trial Results. 2009.5.15..
Contraception 2005, 71, 122-129.

Also Published As

Publication number Publication date
KR20120107492A (ko) 2012-10-02
JP6082249B2 (ja) 2017-02-15
ES2641613T3 (es) 2017-11-10
AU2010339867B2 (en) 2014-07-24
ZA201204267B (en) 2013-01-31
MX2012006755A (es) 2012-11-23
AU2010339867A1 (en) 2012-07-19
CA2782075C (en) 2015-06-30
BR112012014059A2 (pt) 2016-07-05
EP2512486B1 (en) 2017-06-28
JP2013514984A (ja) 2013-05-02
WO2011084668A1 (en) 2011-07-14
EP2512486A1 (en) 2012-10-24
KR20180084149A (ko) 2018-07-24
BR112012014059B1 (pt) 2020-03-10
BR112012014059A8 (pt) 2017-12-26
CN102753180A (zh) 2012-10-24
IN2012DN04867A (https=) 2015-09-25
US20130045953A1 (en) 2013-02-21
MX363536B (es) 2019-03-27
US9682087B2 (en) 2017-06-20
NZ600907A (en) 2013-11-29
CA2782075A1 (en) 2011-07-14

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