KR101923746B1 - 후생적 효소의 조절자로서의 치환된 퓨린 및 7-데아자퓨린 화합물 - Google Patents
후생적 효소의 조절자로서의 치환된 퓨린 및 7-데아자퓨린 화합물 Download PDFInfo
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- KR101923746B1 KR101923746B1 KR1020137017337A KR20137017337A KR101923746B1 KR 101923746 B1 KR101923746 B1 KR 101923746B1 KR 1020137017337 A KR1020137017337 A KR 1020137017337A KR 20137017337 A KR20137017337 A KR 20137017337A KR 101923746 B1 KR101923746 B1 KR 101923746B1
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- 0 CC(*1)N([C@](*[C@@](CI*)[C@@]2O)[C@@]2O)C2=C1C(*)NC(*)N2 Chemical compound CC(*1)N([C@](*[C@@](CI*)[C@@]2O)[C@@]2O)C2=C1C(*)NC(*)N2 0.000 description 2
- LXFOLMYKSYSZQS-LURJZOHASA-N CC(C)N(C[C@H]([C@H]([C@H]1O)O)O[C@H]1[n]1c(ncnc2N)c2nc1)[C@H]1C[C@@H](CCc2nc3cc(C(C)(C)C)ccc3[nH]2)C1 Chemical compound CC(C)N(C[C@H]([C@H]([C@H]1O)O)O[C@H]1[n]1c(ncnc2N)c2nc1)[C@H]1C[C@@H](CCc2nc3cc(C(C)(C)C)ccc3[nH]2)C1 LXFOLMYKSYSZQS-LURJZOHASA-N 0.000 description 1
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- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
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- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
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- C—CHEMISTRY; METALLURGY
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
- C07D473/32—Nitrogen atom
- C07D473/34—Nitrogen atom attached in position 6, e.g. adenine
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- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
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- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/14—Pyrrolo-pyrimidine radicals
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- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
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- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
- C07H19/167—Purine radicals with ribosyl as the saccharide radical
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- Obesity (AREA)
- Diabetes (AREA)
- Cardiology (AREA)
- Oncology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US41966110P | 2010-12-03 | 2010-12-03 | |
| US61/419,661 | 2010-12-03 | ||
| PCT/US2011/063044 WO2012075381A1 (en) | 2010-12-03 | 2011-12-02 | Substituted purine and 7 - deazapurine compounds as modulators of epigenetic enzymes |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| KR20130125379A KR20130125379A (ko) | 2013-11-18 |
| KR101923746B1 true KR101923746B1 (ko) | 2018-11-29 |
Family
ID=45444712
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020137017337A Expired - Fee Related KR101923746B1 (ko) | 2010-12-03 | 2011-12-02 | 후생적 효소의 조절자로서의 치환된 퓨린 및 7-데아자퓨린 화합물 |
Country Status (18)
| Country | Link |
|---|---|
| US (5) | US8580762B2 (OSRAM) |
| EP (1) | EP2646444B1 (OSRAM) |
| JP (1) | JP5931905B2 (OSRAM) |
| KR (1) | KR101923746B1 (OSRAM) |
| CN (1) | CN103391939B (OSRAM) |
| AR (1) | AR084408A1 (OSRAM) |
| AU (1) | AU2011336415B2 (OSRAM) |
| BR (1) | BR112013013659B8 (OSRAM) |
| CA (1) | CA2819648C (OSRAM) |
| DK (1) | DK2646444T3 (OSRAM) |
| ES (1) | ES2577027T3 (OSRAM) |
| HR (1) | HRP20160655T1 (OSRAM) |
| IL (1) | IL226651A (OSRAM) |
| MX (1) | MX2013006251A (OSRAM) |
| RU (1) | RU2606514C2 (OSRAM) |
| SI (1) | SI2646444T1 (OSRAM) |
| TW (1) | TWI537271B (OSRAM) |
| WO (1) | WO2012075381A1 (OSRAM) |
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| KR20130124959A (ko) | 2010-12-03 | 2013-11-15 | 에피자임, 인코포레이티드 | 히스톤 메틸전달효소의 7-데아자퓨린 조절제 및 그의 사용방법 |
| EP2646441B1 (en) | 2010-12-03 | 2015-12-02 | Epizyme, Inc. | Carbocycle-substituted purine and 7-deazapurine compounds |
| SI2646444T1 (sl) * | 2010-12-03 | 2016-09-30 | Epizyme, Inc. | Substituirane spojine purina in 7-deazapurina kot modulatorji epigenetskih encimov |
| WO2012082436A2 (en) | 2010-12-03 | 2012-06-21 | Epizyme, Inc. | Modulators of histone methyltransferase, and methods of use thereof |
| US9670463B2 (en) | 2011-10-14 | 2017-06-06 | Children's Medical Center Corporation | Inhibition and enhancement of reprogramming by chromatin modifying enzymes |
| EP2794627B1 (en) | 2011-12-22 | 2018-09-26 | Alios Biopharma, Inc. | Substituted nucleosides, nucleotides and analogs thereof |
| USRE48171E1 (en) | 2012-03-21 | 2020-08-25 | Janssen Biopharma, Inc. | Substituted nucleosides, nucleotides and analogs thereof |
| US9441007B2 (en) | 2012-03-21 | 2016-09-13 | Alios Biopharma, Inc. | Substituted nucleosides, nucleotides and analogs thereof |
| US20150284422A1 (en) | 2012-08-10 | 2015-10-08 | Epizyme, Inc. | Inhibitors of protein methyltransferase dot1l and methods of use thereof |
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Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| WO2004022572A1 (en) | 2002-09-06 | 2004-03-18 | Alchemia Limited | Compounds that interact with kinases |
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