KR101922488B1 - A composition for treating and preventing hair loss containing pozzolan, Sappan wood extract and siegesbockia herb extract - Google Patents

Abstract

An objective of the present invention is to provide a pharmaceutical composition and a cosmetic composition for preventing hair loss and promoting hair growth. Provided is a pharmaceutical composition for preventing hair loss and promoting hair growth which is obtained by adding a sappan wood extract and a siegesbeckia herb extract to natural pozzolan having excellent far infrared ray and negative ion emission, antibacterial, deodorizing, and sterilizing functions; and a cosmetic composition for treating hair loss.

Description

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a composition for preventing hair loss and promoting hair growth comprising pozzolan,

The present invention relates to a composition for preventing hair loss and promoting hair growth comprising natural pozzolans, and more particularly, to a composition for preventing hair loss and hair growth, which comprises, as a main component, natural pozzolan combined with nanoparticle gelite and natural mineral mineral, And more particularly to a composition for promoting hair growth.

The hair is a solid conical fiber composed only of mammals and composed of tightly adherent corneal epithelial cells. The hair grows under normal conditions and stops growing for a while. In other words, it repeats anagen, catagen, and telogen periodically. In adults, hair growth of scalp is about 3 years, regressive is 3 weeks, and resting period is about 3 months. This is called the cycle of hair (mother cycle), and since each human hair has its own mother cycle, it keeps constant number of hair without molting.

In general, the causes of hair loss are genetic factors, progress of aging, medication, radiation therapy and post-mild stress. From the biochemical and physiological point of view, the main causes of hair loss are hyperactivity, scalp blood circulation, It is known as a nutrient deficiency essential for metabolism. These factors alone may cause hair loss, but hair loss factors can be combined to cause synergy, which can accelerate alopecia and make the symptoms worse.

In recent years, as the stress index of modern people has increased, hair loss symptoms have occurred not only in middle-aged and older men but also in young men and women in their 20s and 30s, and the hair and scalp damage caused by heat of shampoo, mousse, This is causing major hair loss.

In order to prevent and treat hair loss, various medicines and external preparations are being used. Finasteride, a medicinal product approved by the US FDA, is used to inhibit the production of 5α-dihydrotestosterone, which is a male hormone that causes hair loss And 6 months to 1 year of taking the effect of suppressing hair loss or hair growth effect is known, but if you stop taking the drug within two months to return to the original problem, sexual decline, loss of sexual function such as erectile dysfunction and women with birth defects There are side effects such as risk. Minoxidil, approved by the US Food and Drug Administration (FDA) for external use, has a capillary vasodilating function to prevent hair loss as it affects the scalp, but it must be applied twice daily, and the drug must remain in the scalp for 3 to 4 hours to some extent. There is an inconvenience to appear. In addition, the corresponding effect is insignificant, and side effects such as itching and irritation appear.

Therefore, there is a desperate need to develop a natural hair loss preventing agent which has no side effects and can be widely used by the general public.

Pozzolan minerals are made of volcanic rocks and are known to be a kind of pyrophyllite. It is known as an orphan material created during the Cretaceous period and its major origin is the minerals found in the village of Pozori, near Bari Island, Italy. It is the site of the Colosseum Stadium, It was used instead. It has been revealed by scholars that pozzolans have been used to preserve these buildings as they have been preserved for many years without cracks and corrosion. Other pozzolans are produced only in very limited regions such as the United States, the United States, Malaysia, and India. Other than Italy and Korea, the fact that there is no germanium component or far-infrared emission effect is also unique. In Asia, there is no such vein in the vast plains of China.

Pozzolan is added to the base material in concrete production and is used as an admixture to improve concrete properties or give special performance to concrete. In addition, pozzolans with good affinity with cement are widely used because they can be used as sludge moisture control and cement substitute solidification aids, and are relatively inexpensive.

Patent No. 514976 entitled " Textile Product Containing Natural Pozzolan " is manufactured by coating, applying and spraying a coating liquid containing natural pozzolana powder in a textile product, and patent No. 480439 entitled " Far infrared ray and anion generating agent and its use "relates to a soil improving agent including natural pozzolan which generates far-infrared rays and anions, and a composition for cultivating crops.

Caepenaceae (Caesapinia sappan L.) is a dried leaf of a deciduous tree belonging to the leguminous plant or a shrub, which is sometimes referred to as firewood, firefighting, red eye, It is collected from time to time throughout the year, and the bark and sapwood are removed, and only the central part is taken and dried. The major components of the cabbage are hematoxylin and flavonoids, and the raw pigment, Brazilian Rin. The Brazilian Rin is oxidized in the air to Brazilian rain. Brazilian lean has been known to control blood pressure, calcium, and hypoglycemia. So far, much research has been conducted on the antimicrobial efficacy of the hydrothermal extract of canola.

Siegesbeckia glabrescens Makino is distributed in Korea, China, Japan and other Asian countries. It is a perennial vegetation of Asteraceae and is called by other names such as a court of first instance, a disciplinary order. It has been used medically for the treatment of paralysis, myalgia, acute hepatitis, hypertension and diabetes.

The present invention is intended to provide a pharmaceutical composition for preventing hair loss and promoting hair growth, which comprises natural pozzolan, an alum extract and an ornithine extract, which are excellent in far infrared ray and anion release, antibacterial, deodorizing and sterilizing functions.

In order to achieve the above object, the present invention provides a pharmaceutical composition for preventing hair loss and promoting hair growth, which comprises a natural pozzolan, an alopecia extract, and an ornithia extract.

The present invention relates to a pharmaceutical composition for preventing hair loss and promoting hair growth, which comprises natural pozzolan, jojoba extract, and noradrenaline extract.

The composition further comprises at least one mineral selected from the group consisting of jade, mica, germanium, elvan, zeolite, and loess. The present invention also relates to a pharmaceutical composition for preventing hair loss and promoting hair growth.

The present invention also relates to a pharmaceutical composition for preventing hair loss and promoting hair growth, wherein the natural pozzolana emits 90 to 97% far infrared rays at a wavelength of 5 to 20 탆.

Further, the present invention relates to a pharmaceutical composition for preventing hair loss and promoting hair growth, characterized by using an aqueous solution containing 40 to 95% (v / v) of ethanol as an extraction solvent in the extraction of callus and scion.

Further, the present invention relates to a pharmaceutical composition for preventing hair loss and promoting hair growth, characterized in that the callus extract and the extract obtained from the extract are extracted and concentrated under reduced pressure or lyophilized.

In addition, the reduced-pressure concentrated or lyophilized marine alien extract and its extract are each dissolved in 0.001-30.0 wt.% In at least one solvent selected from purified water, ethanol, butylene glycol and propylene glycol. ≪ / RTI >

 The present invention also relates to a cosmetic composition for improving hair loss comprising natural pozzolan, apical extract and a snort extract.

In addition, the present invention relates to a cosmetic composition for improving hair loss, characterized in that the natural pozzolan, apical extract and / or snort extract are contained in an amount of 0.001 to 30.0% by weight based on the whole composition. When the content of the natural pozzolan, the root extract and the extract of the present invention is less than 0.001% by weight, the effect of hair growth is scarcely produced. When the content of each ingredient is more than 30.0% by weight, the effect of increasing the content is insignificant and not economical.

The present invention also relates to a cosmetic composition, wherein the cosmetic composition is in the form of a hair or scalp related product such as hair tonic, hair lotion, hair cream, hair spray, hair mousse, hair gel, hair conditioner, hair shampoo, hair rinse, Wherein the composition is a cosmetic composition selected from the group consisting of

The composition of the present invention is effective for generation of far-infrared rays and anions, reduces 5α-reductase, increases VEGF, KGF and IGF-1, thereby preventing hair loss and promoting hair growth.

1 is a graph showing a pozzolan far infrared ray emissivity.
2 is a graph showing the emission power of pozzolan far-infrared rays.
Fig. 3 shows an animal model for evaluating hair restorative efficacy of the composition of Example 1. Fig.
Fig. 4 is a photograph showing the hair-removing effect of the composition of Example 1 at 1 day, 5 days, 10 days, 15 days, 20 days and 25 days, respectively.
FIG. 5 shows the results of the 5α-reductase potency test of the composition of Example 1. FIG.
Figure 6 shows the results for the VEGF efficacy of the Example 1 composition.
Figure 6 shows the results for the KGF efficacy of the Example 1 composition.
Figure 6 shows the results for the IGF-1 efficacy of the Example 1 composition.

Hereinafter, the configuration of the present invention will be described in detail with reference to specific examples. It is to be understood, however, that the following examples are illustrative of the present invention and that the scope of the present invention is not limited to the scope of the embodiments, but it is obvious to those skilled in the art.

<Material>

1) Preparation of pozzolan powder

Domestic pozzolan ores were crushed to produce pozzolana powder.

2) Production of guinea pig extract

The dried beechwood was pulverized to obtain pulverized material, and 10% by weight of 70% ethanol was added to the pulverized material, followed by reflux extraction. The pure extract from which the precipitate was removed was filtered with a filter (0.1 to 1 탆) to obtain a filtrate. Ethanol was removed using a rotary evaporator under reduced pressure and lyophilized to obtain a powdery alum extract.

3) Preparation of extract

The excipient was pulverized to obtain pulverized material, and 10% by weight of 70% ethanol was added to the pulverized material, followed by reflux extraction. The pure extract from which the precipitate was removed was filtered with a filter (0.1 to 1 μm) to obtain a filtrate. Ethanol was removed using a rotary evaporator under reduced pressure, and lyophilized powder was obtained as a sample by lyophilization.

Experimental Example  1: Infrared emission experiment

The present inventor commissioned the Korean Institute of Construction Materials (Far Infrared Application Evaluation Center, 1465-4 Seocho-dong, Seocho-gu, Seoul, Korea) to analyze the composition of pozzolan and the far-infrared emission result. The results of the analysis are shown in Table 1 below. The far-infrared emissivity and the radiant energy of the natural pozzolan were measured by an FT-IR spectrometer at 40 ° C, and the results of far-infrared emission analysis are shown in FIG. 1 and FIG.

ingredient Content (wt% SiO ₂ ) SiO ₂ 65.3 Fe ₂ O ₃ 5.00 TiO ₂ 0.84 Al ₂ O ₃ 13.1 CaO 4.22 MgO 1.85 K ₂ O 4.03 Na ₂ O 0.26 Trace element 5.3

Inspected by Korea Institute of Construction Materials, Inspection method: KS E 3808- '93

Emissivity (5 to 20 탆) Radiant energy (W / m2 占 퐉, 40 占 폚) Experiment 1 0.928 3.74 x 10 ² Experiment 2 0.93 3.74 x 10 ²

Experimental Example  2: Anion generation experiment

The present inventors commissioned the Korea Institute of Construction Materials (KRII) to analyze the anion release of pozzolan. Anion emission analysis was performed by the KICM-FIR-1042 method. The analysis showed that pozzolan itself emitted an average of 668 anions / cc.

Pozzolans can radiate 90 to 97% of far-infrared rays, which are beneficial to human health, at a wavelength of 5 to 20 μm, and may be slightly reduced depending on the amount of mixing with other components. High-purity pozzolans with the above characteristics are useful for the recovery of fatigue, promotion of blood circulation, activation of circulatory system of the human body, skin health of microvascular vessels, fatigue recovery such as muscles and limbs, relieving of headache due to air purification, sterilization, Water purification, air purification, and odor removal.

Among the electromagnetic waves in the wavelength range of 0.76 to 1.00 microns, the light in the wavelength range of 6 to 15 microns is the far-infrared ray and maintains the proper body temperature of 36.5 ° C. The characteristics of the far infrared ray wavelength can be defined as three kinds of radiation, penetration, and resonance. The effects of far infrared rays include blood circulation promoting action, thermal action, growth promoting action, ion action, dry humidifying action, neutralizing action, and resonance action. Among the natural minerals in Korea, there are quartz, diatomaceous earth, silica sand, alumina, ilite, biotite and kaolin, which are widely used for ceramics, glass, building bricks, water purification agents, refractories and cement.

Also, pozzolan is a mineral that emits an extremely large number of anions among natural minerals by releasing an average of 668 ions / cc by itself in the same manner as in Experimental Example 2. The oxygen supply effect, sterilization , Deodorization and the like. Conventional anions occur naturally, as they occur in trees, or artificially, using anion generators. In an enclosed space with an anion generator installed, it may cause a side effect such as a headache and dizziness when it is dormant for a long time, and fishy fish may be produced when anion is released in excess. However, anions generated in nature have no such side effects, and pozzolan releases a certain amount of natural anion generating material, and there is no problem such as fishy smell.

Example  1: Natural Pozzolan , Jojoba extract and Recruitment  Preparation of compositions containing extracts

The pozzolanic herbal composition was prepared by mixing the natural pozzolan powder with the alum extract and the calli extract at a ratio of 1:10:10 (w: w: w).

Experimental Example  3: Example  1 composition of hair growth promoting effect test

The hair growth promoting effect of the composition of Example 1 including natural pozzolan, apical extract and oryzae extract was measured. The rats were completely depilated using a depilatory device and a shaving device on the rats of a 14-week-old male SD rats, treated with distilled water cream on one side and the composition of Example 1 on the other side (Fig. 3). The results were observed at 1 day, 5 days, 10 days, 15 days, 20 days, and 25 days, respectively. It was confirmed that hair growth was much more promoted in the portion treated with the composition of Example 1 (FIG. 4).

Experimental Example  4 : Example  1 &lt; / RTI & 5α - reducing enzyme, VEGF , KGF  And IGF -1

After Experimental Example 3, tissues were sampled at sacrifice. The tissues were ground, put into PBS buffer, and blended with a blender. The tissue samples were then centrifuged at 15,000 rpm for 30 minutes at 4 &lt; 0 &gt; C and Western blot analysis was performed.

One) 5α - reducing enzyme (Figure 5)

 Western blot analysis was performed using the 5 [alpha] -reducing enzyme antibody. As a result, it was confirmed that when the composition of Example 1 was treated, the amount of 5α-reductase protein was decreased (1: control, 2: pozzolan, 3: composition of Example 1 (pozzolan +

2) VEGF  Vascular endothelial growth factor (Figure 6)

Western blot analysis was performed using VEGF antibody. As a result, it was confirmed that the amount of VEGF protein was increased when the composition of Example 1 was treated (1: control, 2: pozzolan, 3: composition of Example 1 (pozzolan +

3) KGF  ( Keratinocyte  growth factor (Figure 7)

Western blot analysis was performed using KGF antibody. As a result, it was confirmed that when the composition of Example 1 was treated, the protein amount of KGF was increased (1: control, 2: pozzolan, 3: composition of Example 1 (pozzolan + callus extract + scarlet extract)).

4) IGF -One ( Insulind  like growth factor-1 (Figure 8)

Western blot analysis was performed using IGF-1 antibody. As a result, it was confirmed that the amount of IGF-1 protein increased when the composition of Example 1 was treated (1: control, 2: pozzolan, 3: composition of Example 1 (pozzolan +

The pozzolan herbicidal mixture of the present invention, which is a combination of a common extract and an oryzae extract, which is known as antimicrobial activity, is effective to reduce 5α-reductase and to inhibit VEGF, KGF and IGF-1 It was found that the hair loss prevention and hair growth promoting effect were excellent, and that it was applied to a pharmaceutical composition such as external preparation for skin, and thus it can be used for hair loss prevention and treatment.

Manufacturing example  1: Preparation of tablets

40 mg of the composition of Example 1

100 mg of corn starch

Lactose 100 mg

Magnesium stearate 2 mg

After mixing the above components, tablets were prepared by tableting according to a conventional preparation method of tablets.

Manufacturing example  2: Preparation of capsules

40 mg of the composition of Example 1

100 mg of corn starch

Lactose 100 mg

2 mg of magnesium stearate

The above components were mixed according to a conventional capsule preparation method and filled in gelatin capsules to prepare capsules.

Manufacturing example  3: Preparation of injection

0.45 mg of the composition of Example 1

Sterile sterilized water for injection

pH adjuster

(2 ml) per 1 ampoule in accordance with the usual injection preparation method.

Manufacturing example  4: Liquid  Produce

22 mg of the composition of Example 1

10g per isomerization

Mannitol 5 g

Purified water quantity

Each component was added to purified water according to a conventional liquid preparation method and dissolved, and the lemon flavor was added in an appropriate amount. Then, the above components were mixed and then purified water was added thereto to adjust the whole volume to 100 ml. The resulting solution was filled in a brown bottle and sterilized to prepare a liquid preparation Respectively.

Manufacturing example  5: Manufacture of spray agent

Composition of Example 1 20 w / v% (1 mg / ml)

Increasing 0.05 w / v%

AT ECO-cide (natural preservative) 0.7w / v%

Purified water quantity

A spraying agent was prepared by mixing the above components according to a conventional spraying method.

Manufacturing example  6: lotion type Skin external medicine  Produce

Composition of Example 1 20 w / v% (1 mg / ml)

Olivem 600 0.6w / v%

Cetyl alcohol 0.07 w / v%

AT ECO-cide (natural preservative) 1.2w / v%

Purified water quantity

And was prepared by mixing the above ingredients according to a conventional lotion type external preparation for skin preparation.

Manufacturing example  7: Cream type Skin external medicine  Produce

Composition of Example 1 20 w / v% (1 mg / ml)

Olivem 600 0.6w / v%

Cetyl alcohol 0.06 w / v%

AT ECO-cide (natural preservative) 1.2w / v%

Purified water quantity

The above ingredients were mixed according to a conventional cream type skin external agent preparation method.

Manufacturing example  8: Ointment type Skin external medicine  Produce

Composition of Example 1 20 w / v% (1 mg / ml)

Motanov 68: 0.7 w / v%

Motanov L: 0.7 w / v%

Montanox 60: 0.2 w / v%

Cetose KD: 0.5w / v%

AT ECO-cide (natural preservative): 1.2w / v%

Purified water quantity

The above ingredients were mixed according to a conventional ointment type external preparation for skin preparation.

Manufacturing example  9: Lotion production

95% ethanol 8 g

0.05 g of polypyrrolidone

0.1 g of oleyl alcohol

0.2 g of polyoxyethylene monooleate

Fragrance 0.2g

0.1 g of p-oxybenzoic acid methyl ester

Small amounts of antioxidants

A small amount of pigment

0.05 g of the composition of Example 1

Glycerin 5 g

Purified water 85.33g

The above ingredients were mixed according to a conventional lotion preparation method.

Manufacturing example  10: Milk production

Cetyl alcohol 1.2g

Squalane 10g

Vaseline 2g

P-oxybenzoic acid ethyl ester

Glycerin monoestearide 1 g

1 g of polyoxyethylene (20 mols added) monooleate

Fragrance 0.1g

0.5 g of the composition of Example 1

Dipropylene glycol 5g

Polyethylene glycol-1500 2 g

Triethanolamine 0.2 g

Purified water 76.2g

The above components were mixed according to a conventional emulsion preparation method.

Manufacturing example  11: Serum preparation

5% Ethyl alcohol 5 g

1.2 g of polyoxyethylene sorbitan monooleate

Kitsulroose 0.3g

0.2 g of sodium hyaluronate

Vitamin E-acetate 0.2g

0.2 g sodium licorice

P-hydroxybenzoic acid ethyl ester

1 g of the composition of Example 1

A suitable amount of pigment

The above ingredients were mixed according to a conventional method for producing a serum.

Manufacturing example  12: Hair shampoo  Produce

0.2 g of disodium edetate

Polyquaternium-10 2 g

Ammonium laureth sulfate 400 g

150 g of ammonium lauryl sulfate

Glycerin 5 g

Cocamidopropyl betaine 50g

Methylparaben 1g

Klycol distearate 30 g

50 g of the composition of Example 1

Salicylic acid 1 g

Fragrance quantity

Purified water balance

The above components were mixed according to a conventional shampoo manufacturing method.

In addition to the above formulation examples, the composition of Example 1 was mixed in an appropriate amount while a hair conditioner, a hair conditioner, a hair pack, a hair tonic, a hair mousse, a hair gel, a hair conditioner or a hair treatment was produced according to a conventional manufacturing method.

Claims (9)

A natural pozzolana powder, a root extract, and a squalane extract in a weight ratio of 1:10:10.
The method according to claim 1,
Wherein the composition further comprises at least one mineral selected from the group consisting of ox, mica, germanium, elvan, zeolite and loess.
The method according to claim 1,
Wherein the natural pozzolan emits 90 to 97% far infrared rays at a wavelength of 5 to 20 占 퐉.
The method according to claim 1,
Wherein an aqueous solution containing 40 to 95% (v / v) of ethanol as a solvent is used in the step of extracting the bonito or the excipient.
The method according to claim 1,
Wherein the extract is extracted and concentrated under reduced pressure or lyophilized.
The method of claim 5,
Wherein the reduced-pressure concentrated or lyophilized extract is dissolved in 0.001-30.0 wt% of at least one solvent selected from purified water, ethanol, butylene glycol and propylene glycol.
Natural pozzolan, alum extract and alum extract in a weight ratio of 1:10:10.
The method of claim 7,
Wherein the natural pozzolan, apical extract, and / or the extract extract is in an amount of 0.001 to 30.0% by weight based on the whole composition.
The method of claim 7,
Wherein the cosmetic composition is selected from hair tonic, hair lotion, hair cream, hair spray, hair mousse, hair gel, hair conditioner, hair shampoo, hair rinse, hair pack and hair treatment.

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