KR101913790B1 - 모기에서 복제 불가능한 약독화된 재조합 알파바이러스 및 그의 용도 - Google Patents

모기에서 복제 불가능한 약독화된 재조합 알파바이러스 및 그의 용도 Download PDF

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KR101913790B1
KR101913790B1 KR1020167029024A KR20167029024A KR101913790B1 KR 101913790 B1 KR101913790 B1 KR 101913790B1 KR 1020167029024 A KR1020167029024 A KR 1020167029024A KR 20167029024 A KR20167029024 A KR 20167029024A KR 101913790 B1 KR101913790 B1 KR 101913790B1
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veev
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스캇 씨 위버
일리야 브이 프롤로프
엘레나 프로로바
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보드 오브 리전츠, 더 유니버시티 오브 텍사스 시스템
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KR1020167029024A 2008-01-24 2009-01-23 모기에서 복제 불가능한 약독화된 재조합 알파바이러스 및 그의 용도 Expired - Fee Related KR101913790B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US6222908P 2008-01-24 2008-01-24
US61/062,229 2008-01-24
PCT/US2009/000458 WO2009131604A2 (en) 2008-01-24 2009-01-23 Attenuated recombinant alphaviruses incapable of replicating in mosquitoes and uses thereof

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KR1020107018777A Division KR101668849B1 (ko) 2008-01-24 2009-01-23 모기에서 복제 불가능한 약독화된 재조합 알파바이러스 및 그의 용도

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KR20160124255A KR20160124255A (ko) 2016-10-26
KR101913790B1 true KR101913790B1 (ko) 2018-12-28

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KR1020167029024A Expired - Fee Related KR101913790B1 (ko) 2008-01-24 2009-01-23 모기에서 복제 불가능한 약독화된 재조합 알파바이러스 및 그의 용도
KR1020107018777A Expired - Fee Related KR101668849B1 (ko) 2008-01-24 2009-01-23 모기에서 복제 불가능한 약독화된 재조합 알파바이러스 및 그의 용도

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US (3) US8426188B2 (enExample)
EP (2) EP2250269B1 (enExample)
JP (1) JP5758632B2 (enExample)
KR (2) KR101913790B1 (enExample)
CN (1) CN102083986B (enExample)
AU (1) AU2009238667A1 (enExample)
CA (2) CA2910235C (enExample)
CO (1) CO6290702A2 (enExample)
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Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL2947149T3 (pl) * 2007-06-21 2018-09-28 Alphavax, Inc. Kasety bez promotora do ekspresji alfawirusowych białek strukturalnych
CA2910235C (en) 2008-01-24 2021-07-06 Scott C. Weaver Attenuated recombinant alphaviruses incapable of replicating in mosquitoes and uses thereof
US8961995B2 (en) 2012-09-20 2015-02-24 Uab Research Foundation Methods and compositions for alphavirus replicons
US9701719B2 (en) 2012-09-27 2017-07-11 Research Development Foundation Attenuated Chikungunya virus
BR112015023205A2 (pt) 2013-03-14 2017-07-18 Takeda Vaccines Inc composições e métodos para formulações de alfavírus vivo atenuado
EP3436062A1 (en) * 2016-03-31 2019-02-06 Takeda Vaccines, Inc. Live, attenuated alphavirus constructs and methods and uses thereof
BR112018074277A2 (pt) * 2016-05-27 2019-10-01 Griffith University vacina de alfavírus artrogênica
JP2020518648A (ja) 2017-05-08 2020-06-25 グリットストーン オンコロジー インコーポレイテッド アルファウイルス新生抗原ベクター
WO2020028749A1 (en) * 2018-08-03 2020-02-06 Uab Research Foundation Methods and compositions for alphavirus vaccine
CN109536464B (zh) * 2018-12-10 2022-06-10 中国科学院武汉病毒研究所 一种缺失衣壳蛋白基因的基孔肯雅病毒感染性克隆及构建方法和在制备减毒疫苗中的应用
AU2020282369A1 (en) 2019-05-30 2022-01-20 Seattle Project Corp. Modified adenoviruses
CA3162690A1 (en) 2019-12-31 2021-07-08 Minoru S. H. Ko Temperature-based transient delivery of nucleic acids and proteins to cells and tissues
WO2022032196A2 (en) 2020-08-06 2022-02-10 Gritstone Bio, Inc. Multiepitope vaccine cassettes

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060251678A1 (en) 2004-09-14 2006-11-09 Ilya Frolov Venezuelan equine encephalitis virus replicons with adaptive mutations in the genome and uses thereof
US20070166820A1 (en) * 2003-03-20 2007-07-19 Smith Jonathan F Alphavirus replicons and helper constructs

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6451592B1 (en) * 1996-04-05 2002-09-17 Chiron Corporation Recombinant alphavirus-based vectors with reduced inhibition of cellular macromolecular synthesis
CA2327189A1 (en) * 2000-12-21 2002-06-21 The Minister Of National Defence Novel dna-based vaccine against the encephalitis alphaviruses
CA2533614C (en) 2004-07-30 2011-05-03 Research In Motion Limited Method and system for coordinating device setting between a communications client and its host device
CA2579507C (en) 2006-03-15 2017-06-13 Institut Pasteur Novel isolated and purified strains of chikungunya virus and polynucleotides and polypeptides sequences, diagnostic and immunogenical uses thereof
CA2910235C (en) * 2008-01-24 2021-07-06 Scott C. Weaver Attenuated recombinant alphaviruses incapable of replicating in mosquitoes and uses thereof

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070166820A1 (en) * 2003-03-20 2007-07-19 Smith Jonathan F Alphavirus replicons and helper constructs
US20060251678A1 (en) 2004-09-14 2006-11-09 Ilya Frolov Venezuelan equine encephalitis virus replicons with adaptive mutations in the genome and uses thereof

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
JOURNAL OF VIROLOGY. 2006, vol. 80, no. 8, pages 4089-4098.

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Publication number Publication date
CN102083986A (zh) 2011-06-01
EP3085787A1 (en) 2016-10-26
WO2009131604A2 (en) 2009-10-29
EP3085787B1 (en) 2020-10-28
MX378503B (es) 2025-03-11
CA2713165A1 (en) 2009-10-29
KR20100106599A (ko) 2010-10-01
CN102083986B (zh) 2014-06-18
NZ587502A (en) 2012-12-21
CA2713165C (en) 2015-12-29
WO2009131604A3 (en) 2009-12-23
KR101668849B1 (ko) 2016-10-24
JP5758632B2 (ja) 2015-08-05
MX367792B (es) 2019-09-05
MX2010007989A (es) 2010-12-21
US20110052634A1 (en) 2011-03-03
ZA201005943B (en) 2011-04-28
IL232032A0 (en) 2014-05-28
IL207167A0 (en) 2010-12-30
US20140010841A1 (en) 2014-01-09
JP2011523347A (ja) 2011-08-11
MX2019010530A (es) 2019-10-15
EP2250269B1 (en) 2016-03-16
US8426188B2 (en) 2013-04-23
MY178870A (en) 2020-10-21
CO6290702A2 (es) 2011-06-20
SG187513A1 (en) 2013-02-28
US9580690B2 (en) 2017-02-28
CA2910235A1 (en) 2009-10-29
KR20160124255A (ko) 2016-10-26
SG10201606111XA (en) 2016-09-29
US20170240919A1 (en) 2017-08-24
AU2009238667A1 (en) 2009-10-29
NZ603790A (en) 2014-08-29
EP2250269A4 (en) 2012-01-04
EP2250269A2 (en) 2010-11-17
CA2910235C (en) 2021-07-06
US10533186B2 (en) 2020-01-14
IL207167A (en) 2014-04-30

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