KR101901457B1 - 간암 암 줄기세포 특성에 기초한 간암의 신규 바이오마커 및 그의 용도 - Google Patents
간암 암 줄기세포 특성에 기초한 간암의 신규 바이오마커 및 그의 용도 Download PDFInfo
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Abstract
본 발명은 간암 줄기세포 및 간암에 대한 신규한 분자 마커를 이용하여 간암 예방 또는 치료용 물질의 스크리닝 방법을 제공한다. 본 발명은 암 줄기세포 및 암에 대한 신규한 분자 마커를 이용하여 간암 예방 또는 치료용 물질의 스크리닝 방법을 제공한다. 본 발명의 간암 또는 암 치료제 타겟은 간암 줄기세포 또는 암 줄기세포에 특이적으로 작용하는 치료제 후보물질을 스크리닝 하는 데 매우 유용하다. 또한, 본 발명을 이용하면 간암 또는 암의 진단 및 예후를 정확하게 분석할 수 있다.
Description
본 발명은 간암 암 줄기세포 특성에 기초한 간암의 신규 바이오마커 및 그의 용도에 관한 것이다.
간염, 간경변 및 간암 등을 포함한 간질환은 한국, 일본, 대만, 중국 및 대부분의 동남아 국가에서 단일 질병으로는 가장 많은 환자가 발생하고 있으며, 장기별 기준으로 간암으로 인한 사망률은 세계적으로 네 번째(50만 5천명) 발병률을 보이고 있다(세계보건기구 1997년도). 또한 간암 환자는 암 발생 중 국내 3위(11.5%)를 차지하고 있다(한국 암발생통계 2002).
현재까지 간암 진단을 위하여, 조직검사를 실시하거나 AFP 및 PIVKA-II와 같은 간암표지 단백질 검사를 실시하고 있으나, 혈청학적으로 조기에 효율적으로 진단할 수 있는 표지자가 충분치 않아 정기적인 초음파 검사 또는 전산화 단층촬영 등의 영상학적 진단에 주로 의존할 수밖에 없는 현실이다.
암 조직에도 일반 장기처럼 암 조직을 유지하고 재생하는 암 줄기세포가 존재하며, 이들 세포는 in vitro에서 부유 배양 시 스피어(sphere)를 형성하게 되고, 스피어 배양으로 얻은 세포는 원 세포주에 비해 강력한 암 형성 능력을 가진다는 것이 보고된 바 있다(A. Dubrovska et al. Proc Natl Acad Sci U S A.: 106, 268-273(2009)). 또한 암 줄기세포는 암의 발생은 물론 기존의 암 치료법이 적용된 후 줄어든 암세포를 재생하는 데 관여함으로써 암의 시작, 재발이나 전이는 물론 항암제 내성에도 관여하므로 암 줄기세포의 증식을 막는 것은 암 치료에 있어서 중요하다(BB Zhou et al. Nature Reviews Drug Discovery: 8, 806-823(2009)).
현재, 선진국에서는 유방암(M. Al-Hajj et al., Proc Natl Acad Sci U S A.: 100(7), 3983-3988(2003)), 간암(ZF Yang et al., Cancer cell; 13, 153-166(2008)), 대장암(P. Dalerba et al., Proc Natl Acad Sci U S A.: 104(24), 10158-63(2007)), 췌장암(C. Li et al. Cancer Res: 67(3) 1030-1037(2007))등의 분야에서 이미 어느 정도의 암 줄기세포에 대한 정보들이 확보되어 있기 때문에, 이들 선진국의 방향과는 차별화 할 수 있는 장기 및 조직의 암 줄기세포에 대한 연구가 필요하다.
본 명세서 전체에 걸쳐 다수의 논문 및 특허문헌이 참조되고 그 인용이 표시되어 있다. 인용된 논문 및 특허문헌의 개시 내용은 그 전체로서 본 명세서에 참조로 삽입되어 본 발명이 속하는 기술 분야의 수준 및 본 발명의 내용이 보다 명확하게 설명된다.
본 발명자들은 간암 암 줄기세포 특성에 기초한 간암의 신규 바이오마커 및 치료용 타겟을 발굴하고자 예의 연구 노력하였다. 그 결과, 본 발명자들은 간암 줄기세포에서 특이적으로 발현되는 단백질들이 간암의 신규 바이오마커가 될 수 있음을 발견하였다. 더불어, 본 발명자들은 발굴된 바이오 마커들이 간암 줄기세포를 진단, 특히 조기 진단할 수 있고, 예후를 판정할 수 있는 마커이며 간암의 치료용 타겟이 될 수 있음을 규명함으로써, 본 발명을 완성하게 되었다.
따라서, 본 발명의 목적은 간암의 진단 또는 예후 분석용 키트를 제공하는 데 있다.
본 발명의 또 다른 목적은 암의 진단 또는 예후 분석용 키트를 제공하는 데 있다.
본 발명의 또 다른 목적은 간암 줄기세포 검출용 키트를 제공하는 데 있다.
본 발명의 또 다른 목적은 암 줄기세포 검출용 키트를 제공하는 데 있다.
본 발명의 또 다른 목적은 간암 예방 또는 치료용 물질의 스크리닝 방법을 제공하는데 있다.
본 발명의 다른 목적은 암 예방 또는 치료용 물질의 스크리닝 방법을 제공하는데 있다.
본 발명의 다른 목적 및 이점은 하기의 발명의 상세한 설명 및 청구범위에 의해 보다 명확하게 된다.
본 발명의 일 양태에 따르면, 본 발명은 서열목록 제1서열의 단백질, 서열목록 제3서열의 단백질 및 서열목록 제5서열의 단백질로 구성된 군으로부터 선택되는 단백질에 특이적으로 결합하는 결합제 또는 서열목록 제2서열의 폴리뉴클레오타이드, 서열목록 제4서열의 폴리뉴클레오타이드 및 서열목록 제6서열의 폴리뉴클레오타이드로 구성된 군으로부터 선택되는 폴리뉴클레오타이드에 특이적으로 결합하는 프라이머 또는 프로브를 포함하는 간암 진단 또는 예후 분석용 키트를 제공한다.
본 발명자들은 간암 줄기세포 특성에 기초한 간암의 신규 바이오마커 및 치료용 타겟을 발굴하고자 예의 연구 노력하였으며, 그 결과, 간암 암 줄기세포에서 특이적으로 발현되는 단백질들이 간암의 신규 바이오마커가 될 수 있음을 발견하였다. 더불어, 본 발명자들은 발굴된 바이오 마커들이 간암을 진단, 특히 조기 진단할 수 있고, 예후를 판정할 수 있는 마커이며 간암의 치료용 타겟이 될 수 있음을 규명하였다.
본 발명은 간암 세포주로부터 분리된 간암 암 줄기세포로부터 특이적으로 발현하는 단백질을 동정하고 이들이 간암 치료 타겟이 될 수 있고, 간암을 조기에 매우 정확하게 진단 및 예후를 분석할 수 있는 특징을 가진다.
본 발명의 상기 3개 마커는 간암 암 줄기세포에서 특이적으로 발현된다. 더욱이, 상기 3개 마커는 간암 세포와 간암 암 줄기세포를 구별할 수 있는 능력, 즉 간암 세포와 비교하여 간암 암 줄기세포에서 고발현되는 발현 패턴을 나타내는 마커이다.
특히, 본 발명의 간암 진단 또는 예후 분석용 키트는 간암 암 줄기세포에 의해 유래되는 간암 진단 또는 예후 분석용 키트이다.
본 명세서에서 표현 “간암 진단 또는 예후 분석용 키트”는 간암의 진단 또는 예후 분석용 조성물이 포함된 키트를 의미한다. 따라서, 상기 표현 “간암의 진단 또는 예후 분석용 키트”는 “간암의 진단 또는 예후 분석용 조성물”과 서로 교차 또는 혼용하여 사용이 가능하다.
본 명세서에서 용어 “진단”은 특정 질병 또는 질환에 대한 한 객체의 감수성(susceptibility)을 판정하는 것, 한 객체가 특정 질병 또는 질환을 현재 가지고 있는지 여부를 판정하는 것, 특정 질병 또는 질환에 걸린 한 객체의 예후(prognosis)(예컨대, 전-전이성 또는 전이성 암 상태의 동정, 암의 단계 결정 또는 치료에 대한 암의 반응성 결정)를 판정하는 것, 또는 테라메트릭스(therametrics)(예컨대, 치료 효능에 대한 정보를 제공하기 위하여 객체의 상태를 모니터링 하는 것)을 포함한다.
본 발명에서 용어 “간암(liver cancer)”이란 일반적으로 간세포에서 기원하는 암을 의미한다. 간암에는 처음부터 간에서 생기는 원발성 간암과 다른 조직에서 발생한 암이 간에 전이되어 발병하는 전이성 간암이 있다. 원인은 대부분 불분명하나, 간경변이 있는 경우가 많으며, 간경변이 있는 환자와 만성 활동성 B형 간염, 또는 B형 간염 보균자에서 간암이 잘 발생하는 것으로 밝혀지고 있다.
본 발명자들은 본 발명의 마커를 사용하면, 개체로부터 간암의 발병여부에 대해 민감도 및 신뢰도가 높은 결과를 얻을 수 있음을 확인하였다.
본 발명에서 간암을 진단하는데 있어서 사용되는 표현 단백질 발현 분석은 생물학적 시료에서 상기 유전자들로부터 발현된 단백질의 존재 여부와 발현 정도를 확인하는 과정으로, 바람직하게는, 상기 단백질에 대하여 특이적으로 결합하는 항체를 이용하여 단백질의 양을 확인하는 것을 의미한다. 이를 위한 분석 방법으로는 웨스턴 블랏, 엘라이자(enzyme linked immunosorbent assay,ELISA), 방사선면역분석(RIA: Radioimmunoassay), 방사 면역확산법(radioimmunodiffusion), 오우크테로니(Ouchterlony) 면역 확산법, 로케트(rocket) 면역전기영동, 조직면역염색, 면역침전 분석법(Immunoprecipitation Assay), 보체 고정 분석법(Complement Fixation Assay), 유세포분석(Fluorescence Activated Cell Sorter, FACS), 단백질 칩(protein chip) 등이 있으나 상기 예에 의해 본 발명의 분석방법이 제한되는 것은 아니다.
본 발명에서 단백질에 특이적으로 결합하는 결합제는 예를 들어, 올리고펩타이드, 모노클로날 항체, 폴리클로날 항체, 키메릭(chimeric) 항체, 리간드, PNA(Peptide nucleic acid) 또는 앱타머(aptamer)이다.
본 발명에서 "항체"란 항원성 부위에 대해서 지시되는 특이적인 단백질 분자를 의미한다. 본 발명의 목적상, 항체는 마커 단백질에 대해 특이적으로 결합하는 항체를 의미하며, 다클론 항체, 단일클론 항체 및 재조합 항체를 모두 포함한다.
상기한 바와 같이 새로운 간암 마커 단백질이 규명되었으므로, 이를 이용하여 항체를 생성하는 것은 당업계에 널리 공지된 기술을 이용하여 용이하게 제조할 수 있다.
다클론 항체는 상기한 간암 마커 단백질 항원을 동물에 주사하고 동물로부터 채혈하여 항체를 포함하는 혈청을 수득하는 당업계에 널리 공지된 방법에 의해 생산할 수 있다. 이러한 다클론 항체는 염소, 토끼, 양, 원숭이, 말, 돼지, 소 개 등의 임의의 동물 종 숙주로부터 제조 가능하다.
단일클론 항체는 당업계에 널리 공지된 하이브리도마 방법(hybridoma method)(Kohler 및 Milstein (1976) European Journal of Immunology 6:511-519 참조), 또는 파지 항체 라이브러리(Clackson et al, Nature, 352:624-628, 1991; Marks et al, J. Mol . Biol ., 222:58, 1-597, 1991) 기술을 이용하여 제조될 수 있다. 상기 방법으로 제조된 항체는 겔 전지영동, 투석, 염 침전, 이온교환 크로마토그래피, 친화성 크로마토그래피 등의 방법을 이용하여 분리, 정제할 수 있다.
또한 본 발명의 항체는 2개의 전체 길이의 경쇄 및 2개의 전체 길이의 중쇄를 가지는 완전한 형태뿐만 아니라, 항체 분자의 기능적인 단편을 포함한다. 항체 분자의 기능적인 단편이란 적어도 항원 결합 기능을 보유하고 있는 단편을 뜻하며, Fab, F(ab'), F(ab') 2 및 Fv 등이 있다.
본 발명에서 효소의 활성형에 결합하는 앱타머는 올리고핵산 또는 펩타이드 분자이며, 앱타머의 일반적인 내용은 Bock LC et al., Nature 355(6360):5646(1992); Hoppe-Seyler F, Butz K "Peptide aptamers: powerful new tools for molecular medicine". J Mol Med . 78(8):42630(2000); Cohen BA, Colas P, Brent R . "An artificial cell-cycle inhibitor isolated from a combinatorial library". Proc Natl Acad Sci USA . 95(24):142727(1998)에 상세하게 개시되어 있다.
본 발명의 바람직한 구현예에 따르면, 본 발명은 간암 및/또는 간암 암 줄기세포를 진단하기 위하여 상기 단백질군으로부터 선택되는 하나 이상의 단백질과 각각 특이적으로 결합하는 올리고펩타이드, 모노클로날 항체, 폴리클로날 항체, 키메릭(chimeric) 항체, 리간드, PNA(Peptide nucleic acid) 또는 앱타머(aptamer)을 포함하며, 보다 바람직하게는 올리고펩타이드, 모노클로날 항체, 폴리클로날 항체 또는 키메릭 항체이고, 보다 더 바람직하게는 모노클로날 항체 또는 폴리클로날 항체이며, 가장 바람직하게는 모노클로날 항체이다.
본 발명에서, 상기 항체는 미소입자(micro particle)와 접합된 항체(conjugated antibody)인 것이 바람직하다. 또한 상기 미소입자는 착색된 라텍스(colored latex) 또는 콜로이드성 금 입자(colloidal gold particle)인 것이 바람직하다. 본 발명에서, 상기 항체는 상기 서술한 20개의 마커에 대한 공지의 mRNA 유전자에 의해 코딩되는 단백질의 발현 수준을 측정할 수 있는 어떠한 항체도 될 수 있으나, 바람직하게는, 상기 키트는 면역분석(immunoassay)용 키트이며, 가장 바람직하게는 상기 키트는 루미넥스 분석 키트, 단백질 마이크로어레이 키트 또는 ELISA 키트이다.
상기 루미넥스 어세이 키트, 단백질 마이크로어레이 키트 및 엘라이자 키트는 상기 단백질군으로부터 선택된 어느 하나 이상의 단백질에 대한 다클론 항체 및 단일클론 항체, 그리고 표지물질이 결합된 상기 다클론 항체와 단일클론 항체에 대한 2차 항체를 포함한다.
본 발명에서 키트의 종류의 예로는 면역크로마토그래피 스트립 키트, 루미넥스 어세이 키트, 단백질 마이크로어레이 키트, 엘라이자 키트, 또는 면역학적 도트 키트등이 있으나, 상기 예에 의해 본 발명에서 사용 가능한 키트의 종류가 제한되는 것은 아니다.
상기 키트는 ELISA를 수행하기 위해 필요한 필수 요소를 추가적으로 포함할 수 있다. ELISA 키트는 마커 단백질에 대한 특이적인 항체를 포함한다. 항체는 각 마커 단백질에 대한 특이성 및 친화성이 높고 다른 단백질에 대한 교차 반응성이 거의 없는 항체로, 단일클론 항체, 다클론 항체 또는 재조합 항체이다. 또한 ELISA 키트는 대조군 단백질에 특이적인 항체를 포함할 수 있다. 그 외 ELISA 키트는 결합된 항체를 검출할 수 있는 시약, 예를 들면, 표지된 2차 항체, 발색단(chromophores), 효소(예: 항체와 컨주게이트됨) 및 그의 기질 또는 항체와 결합할 수 있는 다른 물질 등을 포함할 수 있다.
또한, 상기 키트는 복합마커를 동시에 분석하기 위하여 단백질 마이크로어레이를 수행하기 위해 필요한 필수 요소를 추가적으로 포함할 수 있다. 마이크로어레이 키트는 고체상에 결합된 마커 단백질에 대한 특이적인 항체를 포함한다. 항체는 각 마커 단백질에 대한 특이성 및 친화성이 높고 다른 단백질에 대한 교차 반응성이 거의 없는 항체로, 단일클론 항체, 다클론 항체 또는 재조합 항체이다. 또한 단백질 마이크로어레이 키트는 대조군 단백질에 특이적인 항체를 포함할 수 있다. 그 외 단백질 마이크로어레이 키트는 결합된 항체를 검출할 수 있는 시약, 예를 들면, 표지된 2차 항체, 발색단, 효소(예: 항체와 융합됨) 및 그의 기질 또는 항체와 결합할 수 있는 다른 물질 등을 포함할 수 있다. 단백질 마이크로어레이를 이용하여 시료를 분석하는 방법은, 시료에서 단백질을 분리하고, 분리한 단백질을 단백질 칩과 혼성화시켜서 항원-항체 복합체를 형성시키고, 이를 판독하여, 단백질의 존재 또는 발현 정도를 확인하여, 간암 진단에 필요한 정보를 제공할 수 있다.
루미넥스 어세이(Luminex Assay)는 소량(10-20 ㎕)의 환자 시료를 전 처리하지 않은 상태에서 최대 100종류의 어낼라이트(analyte)를 동시에 측정할 수 있는 고용량(high-throughput) 정량분석방법으로서 감도가 좋고(pg단위), 빠른 시간내에 정량이 가능하여(3-4시간), 기존의 엘라이자(ELISA)나 엘리스팟(ELISPOT)을 대체할 수 있는 분석방법이다. 상기 루미넥스 어세이(Luminex Assay)는 96-웰 플레이트(well plate)에 있는 각각의 웰에서 100가지 이상의 생물학적 시료를 동시에 분석할 수 있는 멀티플렉스 형광 마이크로플레이트 (multiplexed fluorescent microplate) 분석방법으로 두 종류의 레이져 감지기(laser detector)를 사용하여 실시간으로 신호전달을 진행시킴으로 100개 이상의 다른 색깔 군의 폴리스티렌 비드(polystyrene bead)를 구별하여 정량한다. 상기 100개의 비드는 다음과 같은 방법으로 구별되도록 구성된다. 한쪽은 붉은 형광 비드(red fluorescence bead)가 열 단계 이상으로 나뉘어 있고, 다른 한 쪽은 오렌지 형광 비드(orange fluorescence bead)가 열 단계로 나뉘어 강도(intensity)의 차이를 보이며 그 사이의 비드(bead)들은 레드(red)와 오렌지(orange)의 비율(ratio)이 각각 다른 비율로 섞여 있어 전체적으로 100개의 색-코드 비드 세트(color-coded bead set)를 구성하고 있다. 또한 각각의 비드에는 분석하고자 하는 단백질의 항체가 부착되어 있어 이를 이용한 면역항체반응으로 단백질 정량이 가능하다. 이 시료는 두개의 레이저(laser)를 사용하여 분석하는데, 하나의 레이저(laser)는 비드(bead)를 감지(detection)하여 비드 고유번호를 알아내고, 다른 레이저는 비드에 붙어 있는 항체와 반응한 시료 속의 단백질을 감지하게 된다. 따라서 한 웰에서 동시에 100가지의 생체 내 단백질 분석이 가능하다. 이 분석은 15 ㎕ 정도의 적은 시료로도 감지가 가능한 장점이 있다.
본 발명의 루미넥스(Luminex) 어세이를 수행할 수 있는 루미넥스(Luminex) 키트는 마커 단백질에 대한 특이적인 항체를 포함한다. 항체는 각 마커 단백질에 대한 특이성 및 친화성이 높고 다른 단백질에 대한 교차 반응성이 거의 없는 항체로, 단일클론 항체, 다클론 항체 또는 재조합 항체이다. 또한 루미넥스 키트는 대조군 단백질에 특이적인 항체를 포함할 수 있다. 그 외 루미넥스 키트는 결합된 항체를 검출할 수 있는 시약, 예를 들면, 표지된 2차 항체, 발색단, 효소(예: 항체와 접합됨) 및 그의 기질 또는 항체와 결합할 수 있는 다른 물질 등을 포함할 수 있다. 상기 항체는 미소입자(micro particle)와 접합된 항체(conjugated antibody)일 수 있으며, 또한 상기 미소입자는 착색된 라텍스(colored latex) 또는 콜로이드성 금 입자(colloidal gold particle)일 수 있다.
본 발명의 간암 진단 또는 예후 분석용 키트에서, 상기 간암 진단용 면역크로마토그래피 스트립을 포함하는 간암 진단 키트는, 5분내 분석결과를 알 수 있는 래피드 테스트(Rapid test)를 수행하기 위해 필요한 필수 요소를 포함하는 것을 특징으로 하는 진단 키트일 수 있다. 상기 면역크로마토그래피 스트립은 (a) 시료가 흡수되는 샘플패드(sample pad); (b) 시료 내의 상기 20개의 유전자 군으로부터 선택된 어느 하나 이상의 유전자의 단백질과 결합하는 결합 패드(conjugate pad); (c) 상기 20개의 유전자 군으로부터 선택된 어느 하나 이상의 유전자의 단백질에 대한 단일클론 항체를 포함하는 반응선(test line) 및 대조선(control line)이 처리되어 있는 반응 막(test membrane); (d) 잔량의 시료가 흡수되는 흡수패드(absorption pad); 및 (e) 지지체를 포함하는 것이 바람직하다. 또한 면역크로마토그래피 스트립 (Immunochromatographic strip)을 포함하는 래피드 테스트 키트는 마커 단백질에 대한 특이적인 항체를 포함한다. 상기 항체는 각 마커 단백질에 대한 특이성 및 친화성이 높고 다른 단백질에 대한 교차 반응성이 거의 없는 항체로, 단일클론 항체, 다클론 항체 또는 재조합 항체이다. 또한 래피드 테스트 키트는 대조군 단백질에 특이적인 항체를 포함할 수 있다. 그 외 래피드 테스트 키트는 결합된 항체를 검출할 수 있는 시약, 예를 들면, 특이항체와 2차 항체가 고정된 나이트로셀룰로오스 멤브레인, 항체가 결합된 비드에 결합된 멤브레인, 흡수 패드와 샘플 패드 등 진단에 필요한 다른 물질 등을 포함할 수 있다.
본 발명에서 면역학적 도트 어세이에 의한 단백질 발현 수준의 측정은 (a) 막에 생물학적 시료를 점적(dotting)하는 단계; (b) 상기 20 개의 유전자로 구성된 군으로부터 선택된 어느 하나 이상의 유전자의 단백질에 특이적인 항체를 상기 점적된 막에 반응시키는 단계; 및 (c) 상기 반응시킨 막에 표시체가 접합된 2차 항체를 첨가하고 발색시키는 단계를 포함하는 것이 바람직하고, 상기 엘라이자 어세이는 (a) 상기 20개의 마커에 대한 염기서열을 갖는 유전자 군에서 선택된 어느 하나 이상의 유전자의 단백질에 특이적인 항체 1을 고상체에 흡착시키는 단계; (b) 상기 고상체에 흡착된 항체 1과 간암 의심 환자의 생물학적 시료를 접촉시켜 항원-항체 복합체 형성하는 단계; (c) 표지물질이 결합된 상기 20개의 마커에 대한 염기서열을 갖는 유전자 군에서 선택된 1개 이상의 유전자에 의해 코딩되는 단백질에 특이적인 항체 2를 처리하여 상기 복합체와 결합시키는 단계; 및 (d) 상기 표지물질을 검출하여 단백질의 농도를 측정하는 단계를 포함하는 샌드위치 엘라이자 어세이인 것이 바람직하며, 상기 단백질 마이크로어레이 어세이는 (a) 상기 20개의 마커로 구성된 유전자 군에서 선택된 1개 이상의 유전자의 단백질에 특이적인 다클론 항체를 칩에 고정시키는 단계; (b) 상기 고정된 다클론 항체 1을 간암 의심 환자의 생물학적 시료와 접촉시켜 항원-항체 복합체 형성하는 단계; (c) 표지물질이 결합된 상기 20개의 마커에 대한 염기서열을 갖는 유전자 군에서 선택된 어느 하나 이상의 유전자에 의해 코딩되는 단백질에 특이적인 단일클론 항체를 처리하여 상기 복합체와 결합시키는 단계; 및 (d) 상기 표지물질을 검출하여 단백질의 농도를 측정하는 단계를 포함하는 것이 바람직하다.
상기 분석 방법들을 통하여, 정상 대조군에서의 항원-항체 복합체의 형성량과 간암 의심 환자에서의 항원-항체 복합체의 형성량을 비교할 수 있고, 간암 마커 유전자에서 단백질로의 유의한 발현량의 증가 여부를 판단하여, 간암 의심 환자의 실제 간암 발병 여부를 진단할 수 있다.
본 발명에서 용어 항원-항체 복합체란 간암 마커 단백질과 이에 특이적인 항체의 결합물을 의미하고, 항원-항체 복합체의 형성량은 검출 라벨(detection label)의 시그널의 크기를 통해서 정량적으로 측정 가능하다.
이러한 검출 라벨은 효소, 형광물, 리간드, 발광물, 미소입자 (microparticle), 레독스 분자 및 방사선 동위원소로 이루어진 그룹 중에서 선택할 수 있으며, 반드시 이로 제한되는 것은 아니다. 검출 라벨로서 효소가 사용되는 경우 이용 가능한 효소에는 β-글루쿠로니다제, β-D-글루코시다제, β-D-갈락토시다제, 우레아제, 퍼옥시다아제 또는 알칼라인 포스파타아제, 아세틸콜린에스테라제, 글루코즈 옥시다제, 헥소키나제와 GDPase, RNase, 글루코즈 옥시다제와 루시페라제, 포스포프럭토키나제, 포스포에놀피루베이트 카복실라제, 아스파르테이트 아미노트랜스페라제, 포스페놀피루베이트 데카복실라제, β-라타마제 등이 있으며 이로 제한되지 않는다. 형광물에는 플루오레신, 이소티오시아네이트, 로다민, 피코에리테린, 피코시아닌, 알로피코시아닌, o-프탈데히드, 플루오레스카민 등이 있으며 이로 제한되지 않는다. 리간드에는 바이오틴 유도체 등이 있으며 이로 제한되지 않는다. 발광물에는 아크리디늄 에스테르, 루시페린, 루시퍼라아제 등이 있으며 이로 제한되지 않는다. 미소입자에는 콜로이드 금, 착색된 라텍스 등이 있으며 이로 제한되지 않는다. 레독스 분자에는 페로센, 루테늄 착화합물, 바이올로젠, 퀴논, Ti 이온, Cs 이온, 디이미드, 1,4-벤조퀴논, 하이드로퀴논, K4 W(CN)8 , [Os(bpy) 3 ] 2+ ,[RU(bpy) 3 ] 2+, [MO(CN) 8 ] 4- 등이 포함되며 이로 제한되지 않는다. 방사선동위원소에는 3H, 14C, 32P, 35S, 36Cl, 51Cr, 57Co, 58Co, 59Fe, 90Y, 125I, 131I , 186Re 등이 포함되며 이로 제한되지 않는다.
단백질 발현수준 측정은 바람직하게는, ELISA법을 이용하는 것이다. ELISA는 고체 지지체에 부착된 항원을 인지하는 표지된 항체를 이용하는 직접적 ELISA, 고체 지지체에 부착된 항원을 인지하는 항체의 복합체에서 포획 항체를 인지하는 표지된 항체를 이용하는 간접적 ELISA, 고체 지지체에 부착된 항체와 항원의 복합체에서 항원을 인지하는 표지된 또 다른 항체를 이용하는 직접적 샌드위치 ELISA, 고체 지지체에 부착된 항체와 항원의 복합체에서 항원을 인지하는 또 다른 항체와 반응시킨 후 이 항체를 인지하는 표지된 2차 항체를 이용하는 간접적 샌드위치 ELISA 등 다양한 ELISA 방법을 포함한다. 보다 바람직하게는, 고체 지지체에 항체를 부착시키고 시료를 반응시킨 후 항원-항체 복합체의 항원을 인지하는 표지된 항체를 부착시켜 효소적으로 발색시키거나 항원-항체 복합체의 항원을 인지하는 항체에 대해 표지된 2차 항체를 부착시켜 효소적으로 발색시키는 샌드위치 ELISA 방법에 의해서 검출한다. 간암 마커 단백질과 항체의 복합체 형성 정도를 확인하여, 간암 발병 여부를 확인할 수 있다.
또한, 바람직하게는, 상기 간암 마커에 대한 하나 이상의 항체를 이용한 웨스턴 블랏을 이용하는 것이다. 시료에서 전체 단백질을 분리하고, 이를 전기영동하여 단백질을 크기에 따라 분리한 다음, 니트로셀루로즈 막으로 이동시켜 항체와 반응시킨다. 생성된 항원-항체 복합체의 양을 표지된 항체를 이용하여 확인하는 방법으로 유전자의 발현에 의해 생성된 단백질의 양을 확인하여, 간암 발병 여부를 확인할 수 있다. 상기 검출 방법은 대조군에서의 마커 유전자의 발현량과 간암이 발병한 세포에서의 마커 유전자의 발현량을 조사하는 방법으로 이루어진다. mRNA 또는 단백질 수준은 상기한 마커 단백질의 절대적(예: ㎍/㎖) 또는 상대적(예: 시그널의 상대 강도) 차이로 나타낼 수 있다.
또한, 바람직하게는, 상기 간암 마커에 대한 하나 이상의 항체를 이용한 면역조직 염색을 실시하는 것이다. 정상 간조직 및 간암으로 의심되는 조직을 채취 및 고정한 후, 당업계에서 널리 공지된 방법으로 파라핀 포매 블록을 제조한다. 이들을 수 ㎛ 두께의 절편으로 만들어 유리 슬라이드에 붙인 후, 이와 상기의 항체 중 선택된 1개와 공지의 방법에 의하여 반응시킨다. 이후, 반응하지 못한 항체는 세척하고, 상기에 언급한 검출라벨 중의 하나로 표지하여 현미경 상에서 항체의 표지 여부를 판독한다.
또한, 바람직하게는, 상기 간암 마커에 대한 하나 이상의 항체가 기판 위의 정해진 위치에 배열되어 고밀도로 고정화되어 있는 단백질 칩을 이용하는 것이다. 단백질 칩을 이용하여 시료를 분석하는 방법은, 시료에서 단백질을 분리하고, 분리한 단백질을 단백질 칩과 혼성화시켜서 항원-항체 복합체를 형성시키고, 이를 판독하여, 단백질의 존재 또는 발현 정도를 확인하여 간암 발병 여부를 확인할 수 있다.
본 발명에서의 생물학적 시료는 조직, 세포, 혈액, 혈청, 혈장, 타액, 뇌척수액 또는 뇨를 의미하고, 바람직하게는 혈액 또는 혈청을 의미하며, 가장 바람직하게는 혈청을 의미한다.
본 발명에서 간암을 진단하기 위하여 사용되는 표현폴리뉴클레오타이드 측정은 생물학적 시료에서 본원 발명의 단백질 마커를 코딩하는 폴리뉴클레오타이드 존재 여부와 발현 정도를 확인하는 과정으로 폴리뉴클레오타이드의 양을 측정하는 것을 의미한다. 이를 위한 분석 방법으로는 역전사 중합효소반응(RT-PCR), 경쟁적 역전사 중합효소반응(Competitive RT-PCR), 실시간 역전사 중합효소반응(Real-time RT-PCR), RNase 보호 분석법(RPA; RNase protection assay), 노던 블럿팅(Northern blotting), DNA 칩 등이 있으나 이에 한정되는 것은 아니다.
본 발명에서 마커로 사용되는 상기 단백질군으로부터 선택되는 각각의 단백질 마커를 코딩하는 염기서열은, 이들 서열과 상동성을 갖는 염기서열을 포함할 수 있다.
바람직하게는, 본 발명에서의 폴리뉴클레오타이드는 DNA 또는 mRNA의 단편을 의미한다.
본 발명의 진단용 키트에서 이용되는 프로브 또는 프라이머는 상기 각각의 단백질을 코딩하는 폴리뉴클레오타이드 서열 및 폴리뉴클레오티드 서열에 대하여 상보적인 서열을 갖는다.
본 발명의 "프라이머"는 짧은 자유 3말단 수산화기를 가지는 핵산 서열로 상보적인 템플레이트(template)와 염기쌍을 형성할 수 있고 템플레이트 가닥 복사를 위한 시작 지점으로 기능을 하는 짧은 핵산 서열을 의미한다. 프라이머는 적절한 완충용액 및 온도에서 중합반응(즉, DNA 중합효소 또는 역전사효소)을 위한 시약 및 상이한 4가지 뉴클레오사이드 트리포스페이트의 존재하에서 DNA 합성을 개시할 수 있다. 본 발명의 프라이머는, 각 마커 유전자 특이적인 프라이머로 7개 내지 50개의 뉴클레오타이드 서열을 가진 센스 및 안티센스 핵산이다. 프라이머는 DNA 합성의 개시점으로 작용하는 프라이머의 기본 성질을 변화시키지 않는 추가의 특징을 혼입할 수 있다.
본 발명의 프라이머는 포스포르아미다이트 고체 지지체 방법, 또는 기타 널리 공지된 방법을 사용하여 화학적으로 합성할 수 있다. 이러한 핵산 서열은 또한 당해 분야에 공지된 많은 수단을 이용하여 변형시킬 수 있다. 이러한 변형의 비제한적인 예로는 메틸화, 캡화, 천연 뉴클레오타이드 하나 이상의 동족체로의 치환, 및 뉴클레오타이드 간의 변형, 예를 들면, 하전되지 않은 연결체(예: 메틸 포스포네이트, 포스포트리에스테르, 포스포로아미데이트, 카바메이트 등) 또는 하전된 연결체(예: 포스포로티오에이트, 포스포로디티오에이트 등)로의 변형이 있다. 핵산은 하나 이상의 부가적인 공유 결합된 잔기, 예를 들면, 단백질(예: 뉴클레아제, 독소, 항체, 시그날 펩타이드, 폴리-L-리신 등), 삽입제(예: 아크리딘, 프소랄렌 등), 킬레이트화제(예: 금속, 방사성 금속, 철, 산화성 금속 등), 및 알킬화제를 함유할 수 있다. 본 발명의 핵산 서열은 또한 검출 가능한 시그널을 직접 또는 간접적으로 제공할 수 있는 표지를 이용하여 변형시킬 수 있다. 표지의 예로는 방사성 동위원소, 형광성 분자, 바이오틴 등이 있다.
본 명세서에서 사용된 용어 “프로브”는 자연의 또는 변형된 모노머 또는 연쇄(linkages)의 선형 올리고머를 의미하며, 디옥시리보뉴클레오타이드 및 리보뉴클레오타이드를 포함하고 타깃 뉴클레오타이드 서열에 특이적으로 혼성화 할 수 있으며, 자연적으로 존재하거나 또는 인위적으로 합성된 것이다. 본 발명의 프로브는 바람직하게는 단일쇄이며, 올리고디옥시리보뉴클레오타이드이다.
프로브를 이용하는 경우, 프로브를 cDNA 분자와 혼성화시킨다. 본 발명에서, 적합한 혼성화 조건은 최적화 절차에 의하여 일련의 과정으로 결정될 수 있다. 이런 절차는 연구실에서 사용을 위한 프로토콜을 수립하기 위하여 당업자에 의하여 일련의 과정으로 실시된다. 예를 들어, 온도, 성분의 농도, 혼성화 및 세척 시간, 완충액 성분 및 이들의 pH 및 이온세기 등의 조건은 프로브의 길이 및 GC 양 및 타깃 뉴클레오타이드 서열 등의 다양한 인자에 의존한다. 혼성화를 위한 상세한 조건은 Joseph Sambrook, et al., Molecular Cloning , A Laboratory Manual, Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y.(2001); 및 M.L.M. Anderson, Nucleic Acid Hybridization, Springer-Verlag New York Inc. N.Y.(1999)에서 확인할 수 있다. 예를 들어, 상기 엄격조건 중에서 고 엄격조건은 0.5 M NaHPO4, 7% SDS(sodium dodecyl sulfate), 1 mM EDTA에서 65℃ 조건으로 혼성화하고, 0.1 x SSC(standard saline citrate)/0.1% SDS에서 68℃ 조건으로 세척하는 것을 의미한다. 또는, 고 엄격조건은 6 x SSC/0.05% 소듐 파이로포스페이트에서 48℃ 조건으로 세척하는 것을 의미한다. 저 엄격조건은 예를 들어, 0.2 x SSC/0.1% SDS에서 42℃ 조건으로 세척하는 것을 의미한다.
본 발명의 다른 양태에 따르면, 본 발명은 서열목록 제1서열의 단백질, 서열목록 제3서열의 단백질 및 서열목록 제5서열의 단백질로 구성된 군으로부터 선택되는 단백질에 특이적으로 결합하는 결합제 또는 서열목록 제2서열의 폴리뉴클레오타이드, 서열목록 제4서열의 폴리뉴클레오타이드 및 서열목록 제6서열의 폴리뉴클레오타이드로 구성된 군으로부터 선택되는 폴리뉴클레오타이드에 특이적으로 결합하는 프라이머 또는 프로브를 포함하는 간암 암 줄기세포 검출용 키트를 제공한다.
본 발명에서 단백질에 특이적으로 결합하는 결합제는 예를 들어, 올리고펩타이드, 모노클로날 항체, 폴리클로날 항체, 키메릭(chimeric) 항체, 리간드, PNA(Peptide nucleic acid) 또는 앱타머(aptamer)이다.
본 발명의 다른 양태에 따르면, 본 발명은 다음의 단계를 포함하는 간암 예방 또는 치료용 물질의 스크리닝 방법을 제공한다:
(a) 서열목록 제1서열의 단백질, 서열목록 제3서열의 단백질 및 서열목록 제5서열의 단백질로 구성된 군으로부터 선택되는 단백질 또는 서열목록 제2서열의 폴리뉴클레오타이드, 서열목록 제4서열의 폴리뉴클레오타이드 및 서열목록 제6서열의 폴리뉴클레오타이드로 구성된 군으로부터 선택되는 폴리뉴클레오타이드를 포함하는 세포 또는 조직에 분석하고자 하는 시료를 접촉시키는 단계; 및
(b) 상기 단계 (a)에서의 상기 단백질 또는 폴리뉴클레오타이드의 발현량을 측정하는 단계로서, 상기 시료가 상기 단백질 또는 폴리뉴클레오타이드의 발현을 감소시키는 경우에는 상기 시료는 간암의 예방 또는 치료용 물질로 판정된다.
본 발명에서 간암 예방 또는 치료용 물질의 스크리닝을 위하여 사용되는 표현“세포 또는 조직”은 암 줄기세포 또는 암 조직이며, 바람직하게는 간암 암 줄기세포 또는 간암 조직이다.
본 발명자들은 상기 단백질들로 이루어진 군으로부터 선택되는 단백질 또는 이들을 코딩하는 각각의 폴리뉴클레오타이드의 경우, 일반 간암세포와 달리 간암 암 줄기세포 내에서 그 발현이 현저히 증가한다는 사실을 발견하였다. 일반 간암세포와는 달리 간암 암 줄기세포 내에서만 타겟 단백질 또는 이를 코딩하는 폴리뉴클레오타이드 발현이 특이적으로 현저하게 증가한다는 것은 그것이 암 줄기세포의 생존에 있어 필수적인 요소임을 지시하며, 이의 발현을 차단하는 물질은 암 줄기세포의 성장 억제 및 사멸을 유도함으로써 간암의 근본적 치료에 도움이 되는 물질, 즉 간암 치료제로 판정된다.
상기 단계 (a)에서 사용되는 시료는 단일 화합물 또는 화합물들의 혼합물(예컨대, 천연 추출물 또는 세포 또는 조직 배양물)이다. 시험 물질은 합성 또는 천연 화합물의 라이브러리로부터 얻을 수 있다. 이러한 화합물의 라이브러리를 얻는 방법은 당업계에 공지되어 있다. 합성 화합물 라이브러리는 Maybridge Chemical Co.(UK), Comgenex(USA), Brandon Associates(USA), Microsource(USA) 및 Sigma-Aldrich(USA)에서 상업적으로 구입 가능하며, 천연 화합물의 라이브러리는 Pan Laboratories(USA) 및 MycoSearch(USA)에서 상업적으로 구입 가능하다. 시료는 당업계에 공지된 다양한 조합 라이브러리 방법에 의해 얻을 수 있으며, 예를 들어, 생물학적 라이브러리, 공간 어드레서블 패러럴 고상 또는 액상 라이브러리(spatially addressable parallel solid phase or solution phase libraries), 디컨볼루션이 요구되는 합성 라이브러리 방법, “1-비드 1-화합물” 라이브러리 방법, 그리고 친화성 크로마토그래피 선별을 이용하는 합성 라이브러리 방법에 의해 얻을 수 있다. 분자 라이브러리의 합성 방법은, DeWitt et al., Proc . Natl . Acad . Sci . U.S.A. 90, 6909, 1993; Erb et al. Proc . Natl . Acad . Sci . U.S.A. 91, 11422, 1994; Zuckermann et al., J. Med . Chem . 37, 2678, 1994; Cho et al., Science 261, 1303, 1993; Carell et al., Angew . Chem. Int . Ed . Engl . 33, 2059, 1994; Carell et al., Angew . Chem . Int . Ed . Engl . 33, 2061; Gallop et al., J. Med . Chem . 37, 1233, 1994 등에 개시되어 있다.
본 발명의 다른 양태에 따르면, 본 발명은 다음의 단계를 포함하는 간암 예방 또는 치료용 물질의 스크리닝 방법을 제공한다:
(a) 서열목록 제1서열의 단백질, 서열목록 제3서열의 단백질 및 서열목록 제5서열의 단백질로 구성된 군으로부터 선택되는 단백질을 준비하는 단계;
(b) 상기 단백질에 시험 물질을 접촉시키는 단계; 및
(c) 상기 시험 물질이 상기 단백질에 결합하는지 여부 또는 시험물질이 상기 단백질의 기능을 억제하는지 여부를 분석하는 단계; 상기 시험물질이 상기 단백질에 결합하거나 또는 단백질의 기능을 억제하면 간암의 예방 또는 치료용 물질로 판정된다.
본 발명의 스크리닝 방법에 따르면, 서열목록 제1서열의 단백질, 서열목록 제3서열의 단백질 및 서열목록 제5서열의 단백질로 구성된 군으로부터 선택되는 단백질과 시험 물질을 접촉시킨다.
본 발명에서 이용되는 단백질은 세포 표면에 전시(displaying)되어 있는 형태, 바이러스(예컨대, 박테리오파아지) 표면에 전시되어 있는 형태, 분리된(isolated) 형태 또는 정제된(purified) 형태일 수 있다.
세포 표면 또는 바이러스 표면에 전시되어 있는 단백질을 이용하는 경우, 스크리닝의 신속화 또는 자동화를 위하여 상기 세포 또는 바이러스는 고상의 기질에 고정화시키는 것이 바람직하다. 또한, 분리된(isolated) 또는 정제된(purified) 형태의 단백질도 고상의 기질에 고정화시키는 것이 바람직하다. 기질로서 이용가능 한 것은, 당업계에서 통상적으로 이용되는 어떠한 것도 가능하며, 예를 들어, 폴리스틸렌과 폴리프로필렌과 같은 탄화수소 폴리머, 유리, 금속 및 젤을 포함하나, 이에 한정되지 않는다. 고상의 기질은 딥스틱, 마이크로타이터 플레이트, 입자(예컨대, 비드), 친화성 컬럼 및 면역블롯 막(예컨대, 폴리비닐리덴 플루오라이드 막)의 형태로 제공될 수 있다(참조: 미국 특허 제5,143,825호, 제5,374,530호, 제4,908,305호 및 제5,498,551호). 가장 바람직하게는, 상기 고상 기질은 마이크로타이터 플레이트이다.
본 발명의 스크리닝 방법은 다양한 방식으로 실시할 수 있으며, 특히 당업계에 공지된 다양한 결합 분석(binding assay)에 따라 고속(high throughput) 방식으로 실시할 수 있다.
본 발명의 스크리닝 방법에 있어서, 시험물질 또는 상기 단백질들은 검출가능한 표지(detectable label)로 레이블링될 수 있다. 예를 들어, 상기 검출가능한 표지(detectable label)는, 화학적 표지(예컨대, 바이오틴), 효소 표지(예컨대, 호스래디쉬 퍼옥시다아제, 알칼린 포스파타아제, 퍼옥시다아제, 루시퍼라아제, β-갈락토시다아제 및 β-글루코시다아제), 방사능 표지(예컨대, C14, I125, P32 및 S35), 형광 표지[예컨대, 쿠마린, 플루오레세인, FITC(fluoresein Isothiocyanate), 로다민 6G(rhodamine 6G), 로다민 B(rhodamine B), TAMRA(6-carboxy-tetramethyl-rhodamine), Cy-3, Cy-5, Texas Red, Alexa Fluor, DAPI(4,6-diamidino-2-phenylindole), HEX, TET, Dabsyl 및 FAM], 발광 표지, 화학발광(chemiluminescent) 표지, FRET(fluorescence resonance energy transfer) 표지 또는 금속 표지(예컨대, 금 및 은)이다.
검출가능한 표지가 레이블링된 단백질 또는 시험물질을 이용하는 경우, 단백질과 시험물질 사이의 결합 발생 여부는 표지로부터 나오는 시그널을 검출하여 분석할 수 있다. 예를 들어, 표지로서 알칼린 포스파타아제가 이용되는 경우에는, 브로모클로로인돌일 포스페이트(BCIP), 니트로 블루 테트라졸리움(NBT), 나프톨-AS-B1-포스페이트(naphthol-AS-B1-phosphate) 및 ECF(enhanced chemifluorescence)와 같은 발색반응 기질을 이용하여 시그널을 검출한다. 표지로서 호스 래디쉬 퍼옥시다아제가 이용되는 경우에는 클로로나프톨, 아미노에틸카바졸, 디아미노벤지딘, D-루시페린, 루시게닌(비스-N-메틸아크리디늄 니트레이트), 레소루핀 벤질 에테르, 루미놀, 암플렉스 레드 시약(10-아세틸-3,7-디하이드록시페녹사진), HYR(p-phenylenediamine-HCl and pyrocatechol), TMB(tetramethylbenzidine), ABTS(2,2‘-Azine-di[3-ethylbenzthiazoline sulfonate]), o-페닐렌디아민(OPD) 및 나프톨/파이로닌와 같은 기질을 이용하여 시그널을 검출한다.
택일적으로, 시험물질의 단백질로의 결합 여부는 상호작용물(interactants)의 레이블링 없이 분석할 수도 있다. 예를 들어, 마이크로피지오미터(microphysiometer)를 이용하여 시험물질이 QP-C에 결합하는 지 여부를 분석할 수 있다. 마이크로피지오미터는 LAPS(light-addressable potentiometric sensor)를 이용하여 셀이 그의 환경을 산성화하는 속도를 측정하는 분석 도구이다. 산성화 속도의 변화는, 시험물질과 QP-C 사이의 결합에 대한 지시자(indicator)로 이용될 수 있다(McConnell et al., Science 257:19061912(1992)).
시험물질의 단백질과의 결합 능력은 실시간 이분자 상호작용 분석(BIA)를 이용하여 분석할 수 있다(Sjolander & Urbaniczky, Anal . Chem . 63:23382345(1991), and Szabo et al., Curr . Opin . Struct. Biol . 5:699705(1995)). BIA는 실시간으로 특이적 상호작용을 분석하는 기술로서, 상호작용물(interactants)의 레이블링 없이 실시할 수 있다(예컨대, BIAcore™). 표면 플라즈몬 공명(SPR)에서의 변화는 분자들 사이의 실시간 반응에 대한 지시자(indicator)로 이용될 수 있다.
또한, 본 발명의 스크리닝 방법은, 투-하이브리드 분석 또는 쓰리-하이브리드 분석 방법에 따라 실시할 수 있다(U.S. Pat. No. 5,283,317; Zervos et al., Cell 72, 223232, 1993; Madura et al., J. Biol . Chem . 268, 1204612054, 1993; Bartel et al., BioTechniques 14, 920924, 1993; Iwabuchi et al., Oncogene 8, 16931696, 1993; 및 W0 94/10300). 이 경우, 상기 단백질을 베이트(bait) 단백질로 이용할 수 있다. 이 방법에 따르면, 상기 단백질에 결합하는 물질, 특히 단백질을 스크리닝 할 수 있다. 투-하이브리드 시스템은 분할 가능한 DNA-결합 및 활성화 도메인으로 구성된 전사인자의 모듈 특성에 기초한다. 간단하게는, 이 분석 방법은 두 가지 DNA 컨스트럭트를 이용한다. 예컨대, 하나의 컨스트럭트에서, 서열목록 제2서열의 폴리뉴클레오타이드 및 서열목록 제4서열의 폴리뉴클레오타이드로 구성된 군으로부터 선택되는 폴리뉴클레오타이드를 공지의 전사 인자(예컨대, GAL-4)의 DNA 결합 도메인-코딩 폴리뉴클레오타이드에 융합시킨다. 다른 컨스트럭트에서, 분석 대상의 단백질(“프레이” 또는 “시료”)을 코딩하는 DNA 서열을 상기 공지의 전사인자의 활성화 도메인을 코딩하는 폴리뉴클레오타이드에 융합시킨다. 만일, 베이트 및 프레이가 인 비보에서 상호작용하여 복합체를 형성하면, 전사인자의 DNA-결합 및 활성화 도메인이 인접하게 되며, 이는 리포터 유전자(예컨대, LacZ)의 전사를 촉발하게 된다. 리포터 유전자의 발현을 검출할 수 있으며, 이는 분석 대상의 단백질이 상기 단백질과 결합할 수 있음을 나타내는 것이며, 결론적으로 간암의 예방 또는 치료용 물질로 이용될 수 있음을 나타내는 것이다.
본 발명에서 이용되는 시료는 상술한 단일 화합물 또는 화합물들의 혼합물 이외에, 펩타이드, 항체, 펩타이드 앱타머, 어드넥틴(AdNectin), 어피바디(affibody, 미국 특허 제5,831,012호), 아비머(Avimer, Silverman, J. et al, Nature Biotechnology 23(12):1556(2005)) 또는 쿠니쯔 도메인(Kunitz domain, Arnoux B et al., Acta Crystallogr . D Biol . Crystallogr . 58(Pt 7):12524(2002)), 및 Nixon, AE, Current opinion in drug discovery & development 9(2):2618(2006))을 포함한다.
발명의 다른 양태에 따르면, 본 발명은 다음의 단계를 포함하는 암 예방 또는 치료용 물질의 스크리닝 방법을 제공한다:
(a) 서열목록 제1서열의 단백질, 서열목록 제3서열의 단백질 및 서열목록 제5서열의 단백질로 구성된 군으로부터 선택되는 단백질 또는 서열목록 제2서열의 폴리뉴클레오타이드, 서열목록 제4서열의 폴리뉴클레오타이드 및 서열목록 제6서열의 폴리뉴클레오타이드로 구성된 군으로부터 선택되는 폴리뉴클레오타이드를 포함하는 세포 또는 조직에 분석하고자 하는 시료를 접촉시키는 단계; 및
(b) 상기 단계 (a)에서의 상기 단백질 또는 폴리뉴클레오타이드의 발현량을 측정하는 단계로서, 상기 시료가 상기 단백질 또는 폴리뉴클레오타이드의 발현을 감소시키는 경우에는 상기 시료는 암의 예방 또는 치료용 물질로 판정된다.
본 발명에서 암 예방 또는 치료용 물질의 스크리닝을 위하여 사용되는 표현세포 또는 조직은 암 줄기세포 또는 암 조직이며, 바람직하게는 간암 암 줄기세포 또는 간암 조직이다.
본 발명의 다른 양태에 따르면, 본 발명은 다음의 단계를 포함하는 암 예방 또는 치료용 물질의 스크리닝 방법을 제공한다:
(a) 서열목록 제1서열의 단백질, 서열목록 제3서열의 단백질 및 서열목록 제5서열의 단백질로 구성된 군으로부터 선택되는 단백질을 준비하는 단계;
(b) 상기 단백질에 시험물질을 접촉시키는 단계; 및
(c) 상기 시험 물질이 상기 단백질에 결합하는지 여부 또는 시험물질이 상기 단백질의 기능을 억제하는 지 여부를 분석하는 단계; 상기 시험물질이 상기 단백질에 결합하거나 또는 단백질의 기능을 억제하면 암의 예방 또는 치료용 물질로 판정된다.
상기 본 발명의 스크리닝 방법에 의해 동정되는 암 치료제는 암 조직의 대부분을 차지하는 일반 암세포만를 타겟으로 하는 것이 아니라, 암 조직의 극히 일부만 차지하면서도 암의 발병과 유지, 재발에 핵심 구실을 하는 암 또는 암 줄기세포를 그 타겟으로 하므로, 암의 근본적인 치료를 가능하게 한다.
본 발명의 다른 양태에 따르면, 본 발명은 서열목록 제1서열의 단백질, 서열목록 제3서열의 단백질 및 서열목록 제5서열의 단백질로 구성된 군으로부터 선택되는 단백질에 특이적으로 결합하는 결합제 또는 서열목록 제2서열의 폴리뉴클레오타이드, 서열목록 제4서열의 폴리뉴클레오타이드 및 서열목록 제6서열의 폴리뉴클레오타이드에 특이적으로 결합하는 프라이머 또는 프로브를 포함하는 암 줄기세포 검출용 키트를 제공한다.
상기 암은 예를 들어, 간암, 위암, 폐암, 유방암, 난소암, 간암, 기관지암, 비인두암, 후두암, 췌장암, 방광암, 대장암, 결장암, 자궁경부암, 뇌암, 전립선암, 골암, 두경부암, 피부암, 갑상선암, 담도암, 부갑상선암 및 요관암을 포함하나, 이에 한정되는 것은 아니다.
본 발명의 다른 양태에 따르면, 본 발명은 서열목록 제1서열의 단백질, 서열목록 제3서열의 단백질 및 서열목록 제5서열의 단백질로 구성된 군으로부터 선택되는 단백질에 특이적으로 결합하는 결합제 또는 서열목록 제2서열의 폴리뉴클레오타이드, 서열목록 제4서열의 폴리뉴클레오타이드 및 서열목록 제6서열의 폴리뉴클레오타이드에 특이적으로 결합하는 프라이머 또는 프로브를 포함하는 암 진단 또는 예후 분석용 키트를 제공한다.
본 명세서에서 표현 “암 진단 또는 예후 분석용 키트”는 암의 진단 또는 예후 분석용 조성물이 포함된 키트를 의미한다. 따라서, 상기 표현 “암의 진단 또는 예후 분석용 키트”는 “암의 진단 또는 예후 분석용 조성물”과 서로 교차 또는 혼용하여 사용이 가능하다.
본 발명의 특징 및 이점을 요약하면 다음과 같다:
(ⅰ) 본 발명은 간암 줄기세포 및 간암에 대한 신규한 분자 마커를 이용하여 간암 진단 또는 예후 분석용 키트를 제공한다.
(ⅱ) 본 발명은 암 줄기세포 및 암에 대한 신규한 분자 마커를 이용하여 암 진단 또는 예후 분석용 키트를 제공한다.
(ⅲ) 본 발명은 간암 줄기세포 및 간암에 대한 신규한 분자 마커를 이용하여 간암 예방 또는 치료용 물질의 스크리닝 방법을 제공한다.
(ⅳ) 또한, 본 발명은 암 줄기세포 및 암에 대한 신규한 분자 마커를 이용하여 암 예방 또는 치료용 물질의 스크리닝 방법을 제공한다.
도 1은 10종의 인체 간암 세포주 중에서 스피어를 형성하는 세포주를 나타낸 그림이다.
도 2는 간암 세포주 Huh7로부터 배양한 부착 세포 및 스피어 세포의 형태를 나타낸 그림이다.
도 3은 Huh7 세포로부터 배양한 스피어 세포에서 암 줄기세포 관련 유전자 의 발현변화를 나타낸 그림이다. RT-PCR 데이터는 베타액틴(Betaactin) 유전자의 mRNA 수준에 맞추어 표준화하였다.
도 4는 Huh7의 부착 세포 및 스피어 세포 배양액을 이용한 2-D 젤 이미지 결과를 나타낸 그림이다.
도 5는 Huh7 스피어 세포의 배양액에서 간암 암 줄기세포 관련 분비 단백질의 발현을 확인하기 위해 웨스턴 블롯을 수행한 결과를 나타낸 그림이다.
도 6은 정상, 만성 간염, 간경변 및 간암 환자 혈청에서 간암 암 줄기세포 관련 신규 마커의 단백질 발현을 확인하기 위해 웨스턴 블롯을 수행한 결과를 나타낸 그림이다.
도 2는 간암 세포주 Huh7로부터 배양한 부착 세포 및 스피어 세포의 형태를 나타낸 그림이다.
도 3은 Huh7 세포로부터 배양한 스피어 세포에서 암 줄기세포 관련 유전자 의 발현변화를 나타낸 그림이다. RT-PCR 데이터는 베타액틴(Betaactin) 유전자의 mRNA 수준에 맞추어 표준화하였다.
도 4는 Huh7의 부착 세포 및 스피어 세포 배양액을 이용한 2-D 젤 이미지 결과를 나타낸 그림이다.
도 5는 Huh7 스피어 세포의 배양액에서 간암 암 줄기세포 관련 분비 단백질의 발현을 확인하기 위해 웨스턴 블롯을 수행한 결과를 나타낸 그림이다.
도 6은 정상, 만성 간염, 간경변 및 간암 환자 혈청에서 간암 암 줄기세포 관련 신규 마커의 단백질 발현을 확인하기 위해 웨스턴 블롯을 수행한 결과를 나타낸 그림이다.
이하, 실시예를 통하여 본 발명을 더욱 상세히 설명하고자 한다. 이들 실시예는 오로지 본 발명을 보다 구체적으로 설명하기 위한 것으로, 본 발명의 요지에 따라 본 발명의 범위가 이들 실시예에 의해 제한되지 않는다는 것은 당업계에서 통상의 지식을 가진 자에 있어서 자명할 것이다.
실시예
실험 재료 및 방법
인체 간암 세포주로부터 암 줄기세포의 특성을 갖는 스피어 분리 및 배양
간암 세포주 10주(SNU398, SNU423, SNU449, SNU475, SNU739, SNU878, SNU886, Hep3B, HepG2 및 Huh7)는 모두 한국 세포주 은행(KCLB, Korean Cell Line Bank, Seoul, Korea)에서 구입하였다. 한국 세포주 은행에 의해 제시된 프로토콜에 의해 세포주들을 10% 우태아혈청(FBS; Hyclone, Logan, UT)을 포함하는 RPMI1640(Invitrogen Gibco, Grand Island, NY) 성장배지에서 배양하였다. 스피어 배양을 위하여 간암 세포주들을 EGF(10 ng/ml, R&D Systems Inc., Minneapolis, MN), bFGF(10 ng/㎖, R&D Systems Inc.), 1TS(insulin transferring selenium, Gibco) 및 0.5% BSA(Invitrogen Gibco, Grand Island, NY)를 보충한 무혈청 RPMI 배지에 1000 세포/㎖의 비율로 6-웰 울트라 로우 클러스터 플레이트(Corning Inc., Corning NY)에 접종 후 7-10일 동안 배양하였다(D. Ponti et. al, Cancer Res, 65(13), 5506-5511(2005)). 같은 배양액으로 배양 접시(Nalgene Nunc Int., Rochester, NY)에 부착시켜 부착(adherent) 상태에서 키운 세포를 대조군으로 하였다.
스피어 세포에서 암 줄기세포 관련 유전자들의 발현 분석
RNAeasy Mini kit(QIAGEN, Valencia, CA)를 사용하여 Huh7 세포의 부착 및 스피어 세포로부터 총 RNA를 추출하였다. Superscript II(Gibco BRL, Grand Island, NY)의 반응을 통하여 42℃에서 1시간 동안 추출된 각각의 RNA 2 ㎍를 역전사 반응시켰다. 암 줄기세포 관련 유전자들의 프라이머와 Taq 폴리머라아제에 의한 PCR을 통하여 스피어 세포에서의 암 줄기세포 관련 유전자들의 발현을 분석하였고, 베타 액틴(Beta actin) 유전자의 발현을 대조군으로 하였다. 암 줄기세포 관련 유전자들의 프라이머 염기 서열, PCR 반응 온도 및 싸이클수는 하기 표 1에 나타내었다.
유전자 | 정방향 프라이머 염기서열(5’-3’) | 역방향 프라이머 염기서열 (5’-3’) | Tm/사이클 |
Ihh | CCTGAACTCGCTGGCTATCT | AATACACCCAGTCAAAGCCG | 56℃/35 |
Gli1 | AGAGTCCAGGGGGTTACATA | AGAGTCCAGGGGGTTACATA | 57℃/35 |
Notch3 | ATGGTGGGAACTAAACACAGCT | ATGACCCTGGAGGAAGCACA | 55℃/35 |
Hes1 | GTGCTGTCTGGATGCGGAGT | GAACACTCACACTCAAAGCCC | 55℃/35 |
c-met | CAATGTGAGATGTCTCCAGC | CCTTGTAGATTGCAGGCAGA | 56℃/27 |
β- actin | GGCATCCTCACCCTGAAGTA | GGGGTGTTGAAGGTCTCAAA | 55℃/25 |
스피어 세포에서의 간암 줄기세포 관련 분비 단백질 분석
스피어를 형성하는 세포의 배양액에서 암 줄기세포와 관련된 분비 단백질을 분석하기 위하여, Huh7 세포로부터 부착 세포 또는 스피어 세포를 7-10일간 배양하였다. 그 다음, 무혈청 RPMI 1640 배지(Gibco BRL, Grand Island, NY)로 교환한 후 다시 48시간 동안 배양하였다. 부착 및 스피어의 배양 상층액을 원심분리 및 필터를 이용하여 처리한 후 수득하였다. 다양한 분비 단백질들을 포함한 상층액을 3 kDa 분자-매스 컷오프(molecular-mass cut off: MWCO)를 가진 아미콘 울트라 센트리퓨갈 필터 디바이스를 사용하여 농축시킨 후, 프로테오믹스 분석(2-D젤 분석 및 MALDI-TOF)을 실시하였다. 염색된 젤 이미지 분석 후 차이를 보이는 스팟은 트립신으로 절단시킨 후 MALDI-TOF(matrix assisted laser desorption/ionization-time of flight) 분석을 통하여 동정하였다. 데이타베이스 검색엔진은 MASCOT을 사용하였다(Na K et al., Proteomics (9):3989-3999(2009)).
스피어
세포의 배양액에서
웨스턴
블롯을
통해 간암 줄기세포 관련 분비 단백질의 발현 분석
프로테오믹스 분석에 의해 동정된 분비 단백질들의 발현을 Huh7의 부착 및 스피어 세포 배양액으로부터 확인하기 위하여, 부착 및 스피어 세포 배양 상층액을 원심분리 및 필터를 처리한 후 수득하였다. 3 kDa 분자-매스 컷오프(molecular-mass cut off: MWCO)를 가진 아미콘 울트라 센트리퓨갈 필터 디바이스를 사용하여 농축시킨 후, 단백질 정량을 실시한 후 25 ㎍ 씩 10% SDS-폴리아크릴아미드 젤에 로딩(loading)하여 전기영동하였다. 전기영동에 의해 크기별로 분획된 단백질들을 PVDF 멤브레인(Millipore corporation, Billerica, MA, USA)으로 이동시킨 후, 비특이적 반응을 감소시키기 위하여 5% 논-팻 밀크(non-fat milk)를 첨가한 TBS-T(Tris-buffered saline/0.05% Tween-20)에 1시간 동안 블록킹하였다. 그 다음, 각각의 멤브레인을 프로테오믹스 결과 동정된 분비 단백질들에 해당하는 1차 항체와 4℃에서 16시간 반응시켰다. 1차 항체는 마우스 모노클로날 Titin(Abnova corporation, Taipei), 래빗 폴리클로날 KLHL5(Sigma-Aldrich, Inc., St. Louis, MO) 및 마우스 모노클로날 NUMA1(Abnova corporation, Taipei)을 사용하였다. 1차 항체와 반응시킨 각각의 멤브레인은 TBS-T 버퍼에 세척한 후, HRP(horseradish peroxidase)-콘쥬게이티드 2차 항체(santa cruz biotechnology Inc, santa cruz, CA)와 1시간 동안 반응시켰다. 각각의 단백질은 Enhanced chemiluminescence system(PIERCE, Rockford, IL)을 이용하여 검출하였다.
정상, 만성 간염, 간경변 및 간암 환자 혈청에서 웨스턴 블롯을 통한 간암 암 줄기세포 관련 분비 단백질의 발현 분석
정상, 만성 간염, 간경변 및 간암 환자 혈청에서 웨스턴 블롯을 통한 간암 줄기세포 관련 분비 단백질의 발현 분석을 실시하였다. 발굴된 간암 줄기세포 관련 분비 단백질의 발현을 정상, 만성 간염, 간경변 및 간암 환자 혈청에서 확인하기 위하여 정상 혈청(normal) 3종, 만성 간염 혈청(chronic hepatitis) 3종, 간경변 혈청(liver cirrhosis) 3종, 간암 환자 혈청(hepatocellular carcinoma) 5종을 선정하였다. 선정된 총 14종의 혈청들은 MARS(Multiple affinity removal column system)를 사용하여 혈청내의 6개의 주요 단백질인 알부민, 트란스페린, IgG, IgA, 햅토그로빈(haptoglobin) 및 항-트립신(anti-trypsin)을 제거시킨 후, 3 kDa MWCO(molecular-mass cut off)을 가진 아미콘 울트라 센트리퓨갈 필터 디바이스를 사용하여 농축하였고, 단백질 정량 후 농도 10 ㎍씩 동일한 농도로 10% SDS-폴리아크릴아미드 젤에 로딩하여 전기영동하였다. 전기영동에 의해 크기별로 분획된 단백질들을 PVDF 멤브레인(Millipore corporation, Billerica, MA, USA)으로 이동시킨 후 비특이적 반응을 감소시키기 위하여 5% 논-팻 밀크를 첨가한 TBS-T(Tris-buffered saline/0.05% Tween-20)에서 1시간 동안 블록킹시켰다. 그 다음, 각각의 1차 항체 및 멤브레인을 4℃에서 16시간 반응시켰다. 각각의 1차 항체는 마우스 모노클로날 Titin(Abnova corporation, Taipei), 래빗 폴리클로날 KLHL5(Sigma-Aldrich, Inc., St. Louis, MO) 및 마우스 모노클로날 NUMA1(Abnova corporation, Taipei)은 1:500으로 희석하였다. 1차 항체와 반응시킨 멤브레인은 TBS-T 버퍼로 세척한 후 HRP-콘쥬게이티드 2차 항체(santa cruz biotechnology Inc, santa cruz, CA)와 1시간 동안 반응시켰다. 단백질은 Enhanced chemiluminescence system(PIERCE, Rockford, IL)을 이용하여 검출하였다.
실험 결과
인체 간암 세포주로부터 암 줄기세포의 특성을 갖는 스피어 분리 및 배양
암 줄기세포의 특성을 나타내는 스피어 형성 유무를 확인한 결과, 총 10종의 간암 세포주 중 SNU-398, HepG2, Hep3B 및 Huh7 세포주에서 스피어가 형성됨을 확인하였다. 4가지 세포주 중 Huh-7을 선택하여 후속 실험을 진행하였다(도 1). 도 2는 Huh7의 부착 세포 및 스피어 세포를 비교한 것이다.
Huh7 스피어 세포에서 암 줄기세포 관련 유전자들의 발현 분석
간암 세포주 Huh7으로부터 스피어 세포를 분리 배양하였으며, RT-PCR을 수행하여 다양한 암 줄기세포 관련 유전자들의 발현을 확인하였다. Huh7 세포로부터 유래된 부착 세포에 비해 스피어 세포에서 암 줄기세포 관련 유전자들인 Hedgehog signalling의 Ihh, Gli1 및 Notch signalling의 Notch3 및 Hes1 등의 유전자 발현이 현저히 증가되어(도 3), 스피어 세포내에 다량의 암 줄기세포가 포함되어 있음을 시사한다. 또한, 스피어 세포에서 분비되는 단백질의 프로파일(profile)을 조사함으로 간암 줄기세포 특이 표지자를 예측할 수 있다.
스피어
세포에서의 암 줄기세포 관련 분비 단백질 분석
Huh7의 부착 세포 및 스피어 세포 배양액을 이용하여 2-D 젤 이미지 분석 결과, 컨트롤 젤(부착 세포 배양액)은 267개의 짝지어진 스팟(paired spot)이 발견되었으며, 이 중 컨트롤 젤 대비 스피어 젤(스피어 세포 배양액)에서 2배 이상 증가한 스팟은 9개, 2배 이상 감소한 스팟은 13개였다. 또한 짝 지어지지 않은 스팟(non-paired spot) 중 컨트롤 젤에서만 발견된 스팟은 33개, 스피어 젤에서만 발견된 스팟은 14개임을 확인하였다(도 4). MALDI-TOF 방법을 통하여 짝 지어진 스팟 및 짝 지어지지 않은 스팟에 대해 단백질 동정을 수행하였고, 그 결과, 간암 줄기세포 관련 신규 마커인 NUMA1, Titin 및 KLHL5 단백질을 도출하였다(표 2).
Spot number | Fold change | Accession number | Protein name(human) | Score |
349 | 2.1 | gi31455194 | NUMA 1 protein | 65 |
Spot number | % volume | Accession number | Protein name(human) | Score |
501 | 0.062421 | gi1212992 | Titin | 70 |
519 | 0.029231 | gi51980483 | KLHL5 protein | 68 |
Huh7
스피어
세포 배양액에서 간암 암 줄기세포 관련 단백질의 발현 분석
MALDI-TOF 분석을 통해 동정한 분비 단백질들의 검증을 위해, Huh7세포의 부착 세포 배양액과 스피어 세포 배양액을 상용화된 항체를 사용하여 웨스턴 블랏을 수행하였고, NUMA1, KLHL5 및 Titin의 발현이 스피어의 배양액에서 증가되어 있음을 확인하였다(도 5).
정상, 만성 간염, 간경변 및 간암 환자 혈청에서 간암 암 줄기세포 관련 신규
마커의
단백질 발현 분석
정상인, 만성 간염환자 및 간경변 환자의 혈청에서 기존의 간암의 마커인 AFP 단백질을 대조군으로 간암 암 줄기세포 관련 신규 마커(NUMA1, KLHL5 및 Titin)의 발현을 웨스턴 블랏으로 확인한 결과, 정상인 혈청과 비교하였을 때 간암 환자의 혈청에서 NUMA1, KLHL5 및 Titin의 발현이 현저히 증가되어 있음을 확인하였다(도 6).
이상으로 본 발명의 특정한 부분을 상세히 기술하였는바, 당업계의 통상의 지식을 가진 자에게 있어서 이러한 구체적인 기술은 단지 바람직한 구현예일 뿐이며, 이에 본 발명의 범위가 제한되는 것이 아닌 점은 명백하다. 따라서, 본 발명의 실질적인 범위는 첨부된 청구항과 그의 등가물에 의하여 정의된다고 할 것이다.
<110> INDUSTRY-ACADEMIC COOPERATION FOUNDATION, Yonsei University
<120> PN110391
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<170> KopatentIn 2.0
<210> 1
<211> 734
<212> PRT
<213> KLHL5 human protein
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Ala Tyr Thr Ser Leu Val Leu Val Gly Cys Thr Asn Leu Cys Ala Val
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Leu Phe Ala Arg Cys Leu Asp Asp His Leu Val Ser Leu Arg Met Ser
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Gly Ser Arg Lys Glu Phe Asp Val Lys Gln Ile Leu Lys Ile Arg Trp
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Arg Trp Phe Gly His Gln Ala Ser Ser Pro Asn Ser Thr Val Asp Ser
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Gln Gln Gly Glu Phe Trp Asn Arg Gly Gln Thr Gly Ala Asn Gly Gly
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Arg Lys Phe Leu Asp Pro Cys Ser Leu Gln Leu Pro Leu Ala Ser Ile
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Gly Tyr Arg Arg Ser Ser Gln Leu Asp Phe Gln Asn Ser Pro Ser Trp
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Pro Met Ala Ser Thr Ser Glu Val Pro Ala Phe Glu Phe Thr Ala Glu
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Asp Cys Gly Gly Ala His Trp Leu Asp Arg Pro Glu Val Asp Asp Gly
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Thr Ser Glu Glu Glu Asn Glu Ser Asp Ser Ser Ser Cys Arg Thr Ser
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Asn Ser Ser Gln Thr Leu Ser Ser Cys His Thr Met Glu Pro Cys Thr
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Ser Asp Glu Phe Phe Gln Ala Leu Asn His Ala Glu Gln Thr Phe Lys
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Lys Met Glu Asn Tyr Leu Arg His Lys Gln Leu Cys Asp Val Ile Leu
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Val Ala Gly Asp Arg Arg Ile Pro Ala His Arg Leu Val Leu Ser Ser
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Val Ser Asp Tyr Phe Ala Ala Met Phe Thr Asn Asp Val Arg Glu Ala
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Arg Gln Glu Glu Ile Lys Met Glu Gly Val Glu Pro Asn Ser Leu Trp
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Ser Leu Ile Gln Tyr Ala Tyr Thr Gly Arg Leu Glu Leu Lys Glu Asp
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Asn Ile Glu Cys Leu Leu Ser Thr Ala Cys Leu Leu Gln Leu Ser Gln
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Val Val Glu Ala Cys Cys Lys Phe Leu Met Lys Gln Leu His Pro Ser
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Asn Cys Leu Gly Ile Arg Ser Phe Ala Asp Ala Gln Gly Cys Thr Asp
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Leu His Lys Val Ala His Asn Tyr Thr Met Glu His Phe Met Glu Val
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Ile Arg Asn Gln Glu Phe Val Leu Leu Pro Ala Ser Glu Ile Ala Lys
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Leu Leu Ala Ser Asp Asp Met Asn Ile Pro Asn Glu Glu Thr Ile Leu
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Asn Ala Leu Leu Thr Trp Val Arg His Asp Leu Glu Gln Arg Arg Lys
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Asp Leu Ser Lys Leu Leu Ala Tyr Ile Arg Leu Pro Leu Leu Ala Pro
405 410 415
Gln Phe Leu Ala Asp Met Glu Asn Asn Val Leu Phe Arg Asp Asp Ile
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Glu Cys Arg Lys Leu Ile Met Glu Ala Met Lys Tyr His Leu Leu Pro
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Glu Arg Arg Pro Met Leu Gln Ser Pro Arg Thr Lys Pro Arg Lys Ser
450 455 460
Thr Val Gly Thr Leu Phe Ala Val Gly Gly Met Asp Ser Thr Lys Gly
465 470 475 480
Ala Thr Ser Ile Glu Lys Tyr Asp Leu Arg Thr Asn Met Trp Thr Pro
485 490 495
Val Ala Asn Met Asn Gly Arg Arg Leu Gln Phe Gly Val Ala Val Leu
500 505 510
Asp Asp Lys Leu Tyr Val Val Gly Gly Arg Asp Gly Leu Lys Thr Leu
515 520 525
Asn Thr Val Glu Cys Tyr Asn Pro Lys Thr Lys Thr Trp Ser Val Met
530 535 540
Pro Pro Met Ser Thr His Arg His Gly Leu Gly Val Ala Val Leu Glu
545 550 555 560
Gly Pro Met Tyr Ala Val Gly Gly His Asp Gly Trp Ser Tyr Leu Asn
565 570 575
Thr Val Glu Arg Trp Asp Pro Gln Ala Arg Gln Trp Asn Phe Val Ala
580 585 590
Thr Met Ser Thr Pro Arg Ser Thr Val Gly Val Ala Val Leu Ser Gly
595 600 605
Lys Leu Tyr Ala Val Gly Gly Arg Asp Gly Ser Ser Cys Leu Lys Ser
610 615 620
Val Glu Cys Phe Asp Pro His Thr Asn Lys Trp Thr Leu Cys Ala Gln
625 630 635 640
Met Ser Lys Arg Arg Gly Gly Val Gly Val Thr Thr Trp Asn Gly Leu
645 650 655
Leu Tyr Ala Ile Gly Gly His Asp Ala Pro Ala Ser Asn Leu Thr Ser
660 665 670
Arg Leu Ser Asp Cys Val Glu Arg Tyr Asp Pro Lys Thr Asp Met Trp
675 680 685
Thr Ala Val Ala Ser Met Ser Ile Ser Arg Asp Ala Val Gly Val Cys
690 695 700
Leu Leu Gly Asp Lys Leu Tyr Ala Val Gly Gly Tyr Asp Gly Gln Ala
705 710 715 720
Tyr Leu Asn Thr Val Glu Ala Tyr Asp Pro Gln Thr Asn Glu
725 730
<210> 2
<211> 2427
<212> DNA
<213> KLHL5 human nucleotide
<220>
<221> gene
<222> (1)..(2427)
<220>
<221> CDS
<222> (76)..(2277)
<400> 2
tgtttcatct ttattcatta tcctttgttc tttaaaatct gatatattgg cataaaagta 60
attgtacata tatat atg aat gtg att tat ttt cct tta cat ctt ttt 108
Met Asn Val Ile Tyr Phe Pro Leu His Leu Phe
1 5 10
gtt gtg tac agc agg gca tat act tct ctt gtc ttg gtt gga tgc aca 156
Val Val Tyr Ser Arg Ala Tyr Thr Ser Leu Val Leu Val Gly Cys Thr
15 20 25
aat ctg tgt gca gtg ctt ttt gcc cgt tgc cta gac gat cac ttg gtt 204
Asn Leu Cys Ala Val Leu Phe Ala Arg Cys Leu Asp Asp His Leu Val
30 35 40
tct ctg agg atg tct ggt tct cgt aaa gag ttt gat gtg aaa cag att 252
Ser Leu Arg Met Ser Gly Ser Arg Lys Glu Phe Asp Val Lys Gln Ile
45 50 55
ttg aaa atc aga tgg agg tgg ttt ggt cat caa gca tca tct cct aat 300
Leu Lys Ile Arg Trp Arg Trp Phe Gly His Gln Ala Ser Ser Pro Asn
60 65 70 75
tct aca gtt gac agc cag cag gga gaa ttt tgg aac cga gga cag act 348
Ser Thr Val Asp Ser Gln Gln Gly Glu Phe Trp Asn Arg Gly Gln Thr
80 85 90
gga gca aac ggt ggg aga aag ttt tta gat cca tgt agc cta caa ttg 396
Gly Ala Asn Gly Gly Arg Lys Phe Leu Asp Pro Cys Ser Leu Gln Leu
95 100 105
cct ttg gct tca att ggt tac cga agg tcc agc caa ctg gat ttt cag 444
Pro Leu Ala Ser Ile Gly Tyr Arg Arg Ser Ser Gln Leu Asp Phe Gln
110 115 120
aat tca cct tct tgg cca atg gca tcc acc tct gaa gtc cct gca ttt 492
Asn Ser Pro Ser Trp Pro Met Ala Ser Thr Ser Glu Val Pro Ala Phe
125 130 135
gag ttt aca gca gaa gat tgt ggc ggt gca cat tgg ctg gat aga cca 540
Glu Phe Thr Ala Glu Asp Cys Gly Gly Ala His Trp Leu Asp Arg Pro
140 145 150 155
gaa gtg gat gat ggc act agt gaa gaa gaa aat gaa tct gat tcc agt 588
Glu Val Asp Asp Gly Thr Ser Glu Glu Glu Asn Glu Ser Asp Ser Ser
160 165 170
tca tgc agg act tcc aat agt agt cag aca tta tca tcc tgt cat act 636
Ser Cys Arg Thr Ser Asn Ser Ser Gln Thr Leu Ser Ser Cys His Thr
175 180 185
atg gag cca tgt aca tca gat gaa ttt ttc caa gcc ctt aat cat gcc 684
Met Glu Pro Cys Thr Ser Asp Glu Phe Phe Gln Ala Leu Asn His Ala
190 195 200
gag caa aca ttt aaa aaa atg gaa aac tat ttg aga cat aaa cag ttg 732
Glu Gln Thr Phe Lys Lys Met Glu Asn Tyr Leu Arg His Lys Gln Leu
205 210 215
tgt gat gta att tta gtc gct ggt gat cgc aga att cca gct cac aga 780
Cys Asp Val Ile Leu Val Ala Gly Asp Arg Arg Ile Pro Ala His Arg
220 225 230 235
ttg gtg ctc tcc tct gtc tca gac tat ttt gct gcc atg ttt act aat 828
Leu Val Leu Ser Ser Val Ser Asp Tyr Phe Ala Ala Met Phe Thr Asn
240 245 250
gat gtc aga gag gca aga caa gaa gaa ata aaa atg gaa ggt gta gaa 876
Asp Val Arg Glu Ala Arg Gln Glu Glu Ile Lys Met Glu Gly Val Glu
255 260 265
cca aat tcg ttg tgg tcc ttg atc cag tat gct tat aca ggc cgc ctt 924
Pro Asn Ser Leu Trp Ser Leu Ile Gln Tyr Ala Tyr Thr Gly Arg Leu
270 275 280
gaa tta aaa gaa gat aat att gag tgc ctg tta tct aca gct tgc ctt 972
Glu Leu Lys Glu Asp Asn Ile Glu Cys Leu Leu Ser Thr Ala Cys Leu
285 290 295
ctt cag ctt tca cag gtt gta gaa gca tgc tgt aag ttt tta atg aaa 1020
Leu Gln Leu Ser Gln Val Val Glu Ala Cys Cys Lys Phe Leu Met Lys
300 305 310 315
cag ctt cat cca tcc aac tgt ctt gga att cgt tct ttt gct gat gcc 1068
Gln Leu His Pro Ser Asn Cys Leu Gly Ile Arg Ser Phe Ala Asp Ala
320 325 330
caa ggt tgt aca gat ttg cat aaa gtg gct cac aat tat act atg gag 1116
Gln Gly Cys Thr Asp Leu His Lys Val Ala His Asn Tyr Thr Met Glu
335 340 345
cat ttc atg gaa gta atc aga aac cag gaa ttt gta tta tta cca gcc 1164
His Phe Met Glu Val Ile Arg Asn Gln Glu Phe Val Leu Leu Pro Ala
350 355 360
agc gaa att gca aag ctc ttg gct agt gat gac atg aac att cct aat 1212
Ser Glu Ile Ala Lys Leu Leu Ala Ser Asp Asp Met Asn Ile Pro Asn
365 370 375
gag gag aca ata ttg aat gca ctt ctt act tgg gtc cgt cat gat ttg 1260
Glu Glu Thr Ile Leu Asn Ala Leu Leu Thr Trp Val Arg His Asp Leu
380 385 390 395
gaa cag aga cgg aaa gat cta agt aaa ctt ttg gct tat att agg cta 1308
Glu Gln Arg Arg Lys Asp Leu Ser Lys Leu Leu Ala Tyr Ile Arg Leu
400 405 410
cct ctt ctt gca cca cag ttc ctg gca gac atg gaa aat aat gta ctt 1356
Pro Leu Leu Ala Pro Gln Phe Leu Ala Asp Met Glu Asn Asn Val Leu
415 420 425
ttt cgg gat gat ata gaa tgt cgg aaa ctc att atg gaa gca atg aag 1404
Phe Arg Asp Asp Ile Glu Cys Arg Lys Leu Ile Met Glu Ala Met Lys
430 435 440
tac cat tta tta cca gag aga cga ccc atg tta caa agt cct cgg aca 1452
Tyr His Leu Leu Pro Glu Arg Arg Pro Met Leu Gln Ser Pro Arg Thr
445 450 455
aaa cct agg aag tca act gtt ggt aca tta ttt gca gtt ggg gga atg 1500
Lys Pro Arg Lys Ser Thr Val Gly Thr Leu Phe Ala Val Gly Gly Met
460 465 470 475
gat tca aca aaa gga gca aca agc att gaa aag tat gat ctc cgt aca 1548
Asp Ser Thr Lys Gly Ala Thr Ser Ile Glu Lys Tyr Asp Leu Arg Thr
480 485 490
aat atg tgg act cca gta gca aat atg aat ggg agg agg cta cag ttc 1596
Asn Met Trp Thr Pro Val Ala Asn Met Asn Gly Arg Arg Leu Gln Phe
495 500 505
ggt gtt gca gtg cta gat gac aaa ctg tat gtg gtt gga gga aga gat 1644
Gly Val Ala Val Leu Asp Asp Lys Leu Tyr Val Val Gly Gly Arg Asp
510 515 520
gga ctg aag act ttg aat act gta gag tgc tac aac ccc aaa aca aaa 1692
Gly Leu Lys Thr Leu Asn Thr Val Glu Cys Tyr Asn Pro Lys Thr Lys
525 530 535
act tgg agt gtg atg cca cct atg tcc aca cat aga cat ggc ctt ggt 1740
Thr Trp Ser Val Met Pro Pro Met Ser Thr His Arg His Gly Leu Gly
540 545 550 555
gtg gct gta ctg gaa ggt ccc atg tat gcc gta gga gga cat gat ggc 1788
Val Ala Val Leu Glu Gly Pro Met Tyr Ala Val Gly Gly His Asp Gly
560 565 570
tgg agc tat ctg aac aca gtg gaa aga tgg gac cct cag gct cgc cag 1836
Trp Ser Tyr Leu Asn Thr Val Glu Arg Trp Asp Pro Gln Ala Arg Gln
575 580 585
tgg aat ttt gtt gcc act atg tct acc cct agg agt aca gta ggt gtg 1884
Trp Asn Phe Val Ala Thr Met Ser Thr Pro Arg Ser Thr Val Gly Val
590 595 600
gca gta cta agt gga aaa ctt tat gca gtt ggt ggt cgt gat gga agt 1932
Ala Val Leu Ser Gly Lys Leu Tyr Ala Val Gly Gly Arg Asp Gly Ser
605 610 615
tct tgt ctc aaa tca gta gaa tgt ttt gat cct cat act aat aag tgg 1980
Ser Cys Leu Lys Ser Val Glu Cys Phe Asp Pro His Thr Asn Lys Trp
620 625 630 635
aca ctg tgt gca cag atg tca aaa agg aga ggt ggc gta gga gtg acg 2028
Thr Leu Cys Ala Gln Met Ser Lys Arg Arg Gly Gly Val Gly Val Thr
640 645 650
acc tgg aat gga ctg ctg tat gct ata ggg ggg cac gat gct ccc gca 2076
Thr Trp Asn Gly Leu Leu Tyr Ala Ile Gly Gly His Asp Ala Pro Ala
655 660 665
tcc aac ttg act tcc aga ctc tca gac tgt gtg gaa aga tat gat ccc 2124
Ser Asn Leu Thr Ser Arg Leu Ser Asp Cys Val Glu Arg Tyr Asp Pro
670 675 680
aaa aca gac atg tgg act gca gta gca tcc atg agc atc agc aga gat 2172
Lys Thr Asp Met Trp Thr Ala Val Ala Ser Met Ser Ile Ser Arg Asp
685 690 695
gca gtg ggg gtc tgt tta ctt ggt gat aag tta tat gct gtt ggg ggg 2220
Ala Val Gly Val Cys Leu Leu Gly Asp Lys Leu Tyr Ala Val Gly Gly
700 705 710 715
tat gat gga cag gca tac ctt aat acc gtg gag gct tat gat ccc cag 2268
Tyr Asp Gly Gln Ala Tyr Leu Asn Thr Val Glu Ala Tyr Asp Pro Gln
720 725 730
aca aat gag tag acccaggtat ggcattcatg tttcattatt acactgactc 2320
Thr Asn Glu
tctttttatt aaaacaattc ttatggtaca aaaaaaaaaa aaacatgtcg gccgcctcgg 2380
cctatgtgcg gccgccaccg cggtggaggg ccagcttttg ttccaat 2427
<210> 3
<211> 1193
<212> PRT
<213> NUMA1 human protein
<400> 3
Met Ala Ala Thr Ser Lys Glu Val Ala Arg Leu Glu Thr Leu Val Arg
1 5 10 15
Lys Ala Gly Glu Gln Gln Glu Thr Ala Ser Arg Glu Leu Val Lys Glu
20 25 30
Pro Ala Arg Ala Gly Asp Arg Gln Pro Glu Trp Leu Glu Glu Gln Gln
35 40 45
Gly Arg Gln Phe Cys Ser Thr Gln Ala Ala Leu Gln Ala Met Glu Arg
50 55 60
Glu Ala Glu Gln Met Gly Asn Glu Leu Glu Arg Leu Arg Ala Ala Leu
65 70 75 80
Met Glu Ser Gln Gly Gln Gln Gln Glu Glu Arg Gly Gln Gln Glu Arg
85 90 95
Glu Val Ala Arg Leu Thr Gln Glu Arg Gly Arg Ala Gln Ala Asp Leu
100 105 110
Ala Leu Glu Lys Ala Ala Arg Ala Glu Leu Glu Met Arg Leu Gln Asn
115 120 125
Ala Leu Asn Glu Gln Arg Val Glu Phe Ala Thr Leu Gln Glu Ala Leu
130 135 140
Ala His Ala Leu Thr Glu Lys Glu Gly Lys Asp Gln Glu Leu Ala Lys
145 150 155 160
Leu Arg Gly Leu Glu Ala Ala Gln Ile Lys Glu Leu Glu Glu Leu Arg
165 170 175
Gln Thr Val Lys Gln Leu Lys Glu Gln Leu Ala Lys Lys Glu Lys Glu
180 185 190
His Ala Ser Gly Ser Gly Ala Gln Ser Glu Ala Ala Gly Arg Thr Glu
195 200 205
Pro Thr Gly Pro Lys Leu Glu Ala Leu Arg Ala Glu Val Ser Lys Leu
210 215 220
Glu Gln Gln Cys Gln Lys Gln Gln Glu Gln Ala Asp Ser Leu Glu Arg
225 230 235 240
Ser Leu Glu Ala Glu Arg Ala Ser Arg Ala Glu Arg Asp Ser Ala Leu
245 250 255
Glu Thr Leu Gln Gly Gln Leu Glu Glu Lys Ala Gln Glu Leu Gly His
260 265 270
Ser Gln Ser Ala Leu Ala Ser Ala Gln Arg Glu Leu Ala Ala Phe Arg
275 280 285
Thr Lys Val Gln Asp His Ser Lys Ala Glu Asp Glu Trp Lys Ala Gln
290 295 300
Val Ala Arg Gly Arg Gln Glu Ala Glu Arg Lys Asn Ser Leu Ile Ser
305 310 315 320
Ser Leu Glu Glu Glu Val Ser Ile Leu Asn Arg Gln Val Leu Glu Lys
325 330 335
Glu Gly Glu Ser Lys Glu Leu Lys Arg Leu Val Met Ala Glu Ser Glu
340 345 350
Lys Ser Gln Lys Leu Glu Glu Arg Leu Arg Leu Leu Gln Ala Glu Thr
355 360 365
Ala Ser Asn Ser Ala Arg Ala Ala Glu Arg Ser Ser Ala Leu Arg Glu
370 375 380
Glu Val Gln Ser Leu Arg Glu Glu Ala Glu Lys Gln Arg Val Ala Ser
385 390 395 400
Glu Asn Leu Arg Gln Glu Leu Thr Ser Gln Ala Glu Arg Ala Glu Glu
405 410 415
Leu Gly Gln Glu Leu Lys Ala Trp Gln Glu Lys Phe Phe Gln Lys Glu
420 425 430
Gln Ala Leu Ser Thr Leu Gln Leu Glu His Thr Ser Thr Gln Ala Leu
435 440 445
Val Ser Glu Leu Leu Pro Ala Lys His Leu Cys Gln Gln Leu Gln Ala
450 455 460
Glu Gln Ala Ala Ala Glu Lys Arg His Arg Glu Glu Leu Glu Gln Ser
465 470 475 480
Lys Gln Ala Ala Gly Ala Leu Arg Ala Glu Leu Leu Arg Ala Gln Arg
485 490 495
Glu Leu Gly Glu Leu Ile Pro Leu Arg Gln Lys Val Ala Glu Gln Glu
500 505 510
Arg Thr Ala Gln Gln Leu Arg Ala Glu Lys Ala Ser Tyr Ala Glu Gln
515 520 525
Leu Ser Met Leu Lys Lys Ala His Gly Leu Leu Ala Glu Glu Asn Arg
530 535 540
Gly Leu Gly Glu Arg Ala Asn Leu Gly Arg Gln Phe Leu Glu Val Glu
545 550 555 560
Leu Asp Gln Ala Arg Glu Lys Tyr Val Gln Glu Leu Ala Ala Val Arg
565 570 575
Ala Asp Ala Glu Thr Arg Leu Ala Glu Val Gln Arg Glu Ala Gln Ser
580 585 590
Thr Ala Arg Glu Leu Glu Val Met Thr Ala Lys Tyr Glu Gly Ala Lys
595 600 605
Val Lys Val Leu Glu Glu Arg Gln Arg Phe Gln Glu Glu Arg Gln Lys
610 615 620
Leu Thr Ala Gln Val Glu Glu Leu Ser Lys Lys Leu Ala Asp Ser Asp
625 630 635 640
Gln Ala Ser Lys Val Gln Gln Gln Lys Leu Lys Ala Val Gln Ala Gln
645 650 655
Gly Gly Glu Ser Gln Gln Glu Ala Gln Arg Leu Gln Ala Gln Leu Asn
660 665 670
Glu Leu Gln Ala Gln Leu Ser Gln Lys Glu Gln Ala Ala Glu His Tyr
675 680 685
Lys Leu Gln Met Glu Lys Ala Lys Thr His Tyr Asp Ala Lys Lys Gln
690 695 700
Gln Asn Gln Glu Leu Gln Glu Gln Leu Arg Ser Leu Glu Gln Leu Gln
705 710 715 720
Lys Glu Asn Lys Glu Leu Arg Ala Glu Ala Glu Arg Leu Gly His Glu
725 730 735
Leu Gln Gln Ala Gly Leu Lys Thr Lys Glu Ala Glu Gln Thr Cys Arg
740 745 750
His Leu Thr Ala Gln Val Arg Ser Leu Glu Ala Gln Val Ala His Ala
755 760 765
Asp Gln Gln Leu Arg Asp Leu Gly Lys Phe Gln Val Ala Thr Asp Ala
770 775 780
Leu Lys Ser Arg Glu Pro Gln Ala Lys Pro Gln Leu Asp Leu Ser Ile
785 790 795 800
Asp Ser Leu Asp Leu Ser Cys Glu Glu Gly Thr Pro Leu Ser Ile Thr
805 810 815
Ser Lys Leu Pro Arg Thr Gln Pro Asp Gly Thr Ser Val Pro Gly Glu
820 825 830
Pro Ala Ser Pro Ile Ser Gln Arg Leu Pro Pro Lys Val Glu Ser Leu
835 840 845
Glu Ser Leu Tyr Phe Thr Pro Ile Pro Ala Arg Ser Gln Ala Pro Leu
850 855 860
Glu Ser Ser Leu Asp Ser Leu Gly Asp Val Phe Leu Asp Ser Gly Arg
865 870 875 880
Lys Thr Arg Ser Ala Arg Arg Arg Thr Thr Gln Ile Ile Asn Ile Thr
885 890 895
Met Thr Lys Lys Leu Asp Val Glu Glu Pro Asp Ser Ala Asn Ser Ser
900 905 910
Phe Tyr Ser Thr Arg Ser Ala Pro Ala Ser Gln Ala Ser Leu Arg Ala
915 920 925
Thr Ser Ser Thr Gln Ser Leu Ala Arg Leu Gly Ser Pro Asp Tyr Gly
930 935 940
Asn Ser Ala Leu Leu Ser Leu Pro Gly Tyr Arg Pro Thr Thr Arg Ser
945 950 955 960
Ser Ala Arg Arg Ser Gln Ala Gly Val Ser Ser Gly Ala Pro Pro Gly
965 970 975
Arg Asn Ser Phe Tyr Met Gly Thr Cys Gln Asp Glu Pro Glu Gln Leu
980 985 990
Asp Asp Trp Asn Arg Ile Ala Glu Leu Gln Gln Arg Asn Arg Val Cys
995 1000 1005
Pro Pro His Leu Lys Thr Cys Tyr Pro Leu Glu Ser Arg Pro Ser Leu
1010 1015 1020
Ser Leu Gly Thr Ile Thr Asp Glu Glu Met Lys Thr Gly Asp Pro Gln
1025 1030 1035 1040
Glu Thr Leu Arg Arg Ala Ser Met Gln Pro Ile Gln Ile Ala Glu Gly
1045 1050 1055
Thr Gly Ile Thr Thr Arg Gln Gln Arg Lys Arg Val Ser Leu Glu Pro
1060 1065 1070
His Gln Gly Pro Gly Thr Pro Glu Ser Lys Lys Ala Thr Ser Cys Phe
1075 1080 1085
Pro Arg Pro Met Thr Pro Arg Asp Arg His Glu Gly Arg Lys Gln Ser
1090 1095 1100
Thr Thr Glu Ala Gln Lys Lys Ala Ala Pro Ala Ser Thr Lys Gln Ala
1105 1110 1115 1120
Asp Arg Arg Gln Ser Met Ala Phe Ser Ile Leu Asn Thr Pro Lys Lys
1125 1130 1135
Leu Gly Asn Ser Leu Leu Arg Arg Gly Ala Ser Lys Lys Ala Leu Ser
1140 1145 1150
Lys Ala Ser Pro Asn Thr Arg Ser Gly Thr Arg Arg Ser Pro Arg Ile
1155 1160 1165
Ala Thr Thr Thr Ala Ser Ala Ala Thr Ala Ala Ala Ile Gly Ala Thr
1170 1175 1180
Pro Arg Ala Lys Gly Lys Ala Lys His
1185 1190
<210> 4
<211> 4313
<212> DNA
<213> NUMA1 human nucleotide
<220>
<221> gene
<222> (1)..(4313)
<220>
<221> CDS
<222> (7)..(3585)
<400> 4
gaaaag atg gct gcc acc agc aaa gag gtg gcc cgc ttg gag acc ttg 48
Met Ala Ala Thr Ser Lys Glu Val Ala Arg Leu Glu Thr Leu
1 5 10
gtg cgc aag gca ggt gag cag cag gaa aca gcc tcc cgg gag tta gtc 96
Val Arg Lys Ala Gly Glu Gln Gln Glu Thr Ala Ser Arg Glu Leu Val
15 20 25 30
aag gag cct gcg agg gca gga gac aga cag ccc gag tgg ctg gaa gag 144
Lys Glu Pro Ala Arg Ala Gly Asp Arg Gln Pro Glu Trp Leu Glu Glu
35 40 45
caa cag gga cgc cag ttc tgc agc aca cag gca gcg ctg cag gct atg 192
Gln Gln Gly Arg Gln Phe Cys Ser Thr Gln Ala Ala Leu Gln Ala Met
50 55 60
gag cgg gag gca gag cag atg ggc aat gag ctg gaa cgg ctg cgg gcc 240
Glu Arg Glu Ala Glu Gln Met Gly Asn Glu Leu Glu Arg Leu Arg Ala
65 70 75
gcg ctg atg gag agc cag ggg cag cag cag gag gag cgt ggg cag cag 288
Ala Leu Met Glu Ser Gln Gly Gln Gln Gln Glu Glu Arg Gly Gln Gln
80 85 90
gaa agg gag gtg gcg cgg ctg acc cag gag cgg ggc cgt gcc cag gct 336
Glu Arg Glu Val Ala Arg Leu Thr Gln Glu Arg Gly Arg Ala Gln Ala
95 100 105 110
gac ctt gcc ctg gag aag gcg gcc aga gca gag ctt gag atg cgg ctg 384
Asp Leu Ala Leu Glu Lys Ala Ala Arg Ala Glu Leu Glu Met Arg Leu
115 120 125
cag aac gcc ctc aac gag cag cgt gtg gag ttc gct acc ctg caa gag 432
Gln Asn Ala Leu Asn Glu Gln Arg Val Glu Phe Ala Thr Leu Gln Glu
130 135 140
gca ctg gct cat gcc ctg acg gaa aag gaa ggc aag gac cag gag ttg 480
Ala Leu Ala His Ala Leu Thr Glu Lys Glu Gly Lys Asp Gln Glu Leu
145 150 155
gcc aag ctt cgt ggt ctg gag gca gcc cag ata aaa gag ctg gag gaa 528
Ala Lys Leu Arg Gly Leu Glu Ala Ala Gln Ile Lys Glu Leu Glu Glu
160 165 170
ctt cgg caa acc gtg aag caa ctg aag gaa cag ctg gct aag aaa gaa 576
Leu Arg Gln Thr Val Lys Gln Leu Lys Glu Gln Leu Ala Lys Lys Glu
175 180 185 190
aag gag cac gca tct ggc tca gga gcc caa tct gag gct gct ggc agg 624
Lys Glu His Ala Ser Gly Ser Gly Ala Gln Ser Glu Ala Ala Gly Arg
195 200 205
aca gag cca aca ggc ccc aag ctg gag gca ctg cgg gca gag gtg agc 672
Thr Glu Pro Thr Gly Pro Lys Leu Glu Ala Leu Arg Ala Glu Val Ser
210 215 220
aag ctg gaa cag caa tgc cag aag cag cag gag cag gct gac agc ctg 720
Lys Leu Glu Gln Gln Cys Gln Lys Gln Gln Glu Gln Ala Asp Ser Leu
225 230 235
gaa cgc agc ctc gag gct gag cgg gcc tcc cgg gct gag cgg gac agt 768
Glu Arg Ser Leu Glu Ala Glu Arg Ala Ser Arg Ala Glu Arg Asp Ser
240 245 250
gct ctg gag act ctg cag ggc cag tta gag gag aag gcc cag gag cta 816
Ala Leu Glu Thr Leu Gln Gly Gln Leu Glu Glu Lys Ala Gln Glu Leu
255 260 265 270
ggg cac agt cag agt gcc tta gcc tcg gcc caa cgg gag ttg gct gcc 864
Gly His Ser Gln Ser Ala Leu Ala Ser Ala Gln Arg Glu Leu Ala Ala
275 280 285
ttc cgc acc aag gta caa gac cac agc aag gct gaa gat gag tgg aag 912
Phe Arg Thr Lys Val Gln Asp His Ser Lys Ala Glu Asp Glu Trp Lys
290 295 300
gcc cag gtg gcc cgg ggc cgg caa gag gct gag agg aaa aat agc ctc 960
Ala Gln Val Ala Arg Gly Arg Gln Glu Ala Glu Arg Lys Asn Ser Leu
305 310 315
atc agc agc ttg gag gag gag gtg tcc atc ctg aat cgc cag gtc ctg 1008
Ile Ser Ser Leu Glu Glu Glu Val Ser Ile Leu Asn Arg Gln Val Leu
320 325 330
gag aag gag ggg gag agc aag gag ttg aag cgg ctg gtg atg gcc gag 1056
Glu Lys Glu Gly Glu Ser Lys Glu Leu Lys Arg Leu Val Met Ala Glu
335 340 345 350
tca gag aag agc cag aag ctg gag gag agg ctg cgc ctg ctg cag gca 1104
Ser Glu Lys Ser Gln Lys Leu Glu Glu Arg Leu Arg Leu Leu Gln Ala
355 360 365
gag aca gcc agc aac agt gcc aga gct gca gaa cgc agc tct gct ctg 1152
Glu Thr Ala Ser Asn Ser Ala Arg Ala Ala Glu Arg Ser Ser Ala Leu
370 375 380
cgg gag gag gtg cag agc ctc cgg gag gag gct gag aaa cag cgg gtg 1200
Arg Glu Glu Val Gln Ser Leu Arg Glu Glu Ala Glu Lys Gln Arg Val
385 390 395
gct tca gag aac ctg cgg cag gag ctg acc tca cag gct gag cgt gcg 1248
Ala Ser Glu Asn Leu Arg Gln Glu Leu Thr Ser Gln Ala Glu Arg Ala
400 405 410
gag gag ctg ggc caa gaa ttg aag gcg tgg cag gag aag ttc ttc cag 1296
Glu Glu Leu Gly Gln Glu Leu Lys Ala Trp Gln Glu Lys Phe Phe Gln
415 420 425 430
aaa gag cag gcc ctc tcc acc ctg cag ctc gag cac acc agc aca cag 1344
Lys Glu Gln Ala Leu Ser Thr Leu Gln Leu Glu His Thr Ser Thr Gln
435 440 445
gcc ctg gtg agt gag ctg ctg cca gct aag cac ctc tgc cag cag ctg 1392
Ala Leu Val Ser Glu Leu Leu Pro Ala Lys His Leu Cys Gln Gln Leu
450 455 460
cag gcc gag cag gcc gct gcc gag aaa cgc cac cgt gag gag ctg gag 1440
Gln Ala Glu Gln Ala Ala Ala Glu Lys Arg His Arg Glu Glu Leu Glu
465 470 475
cag agc aag cag gcc gct ggg gca ctg cgg gca gag ctg ctg cgg gcc 1488
Gln Ser Lys Gln Ala Ala Gly Ala Leu Arg Ala Glu Leu Leu Arg Ala
480 485 490
cag cgg gag ctt ggg gag ctg att cct ctg cgg cag aag gtg gca gag 1536
Gln Arg Glu Leu Gly Glu Leu Ile Pro Leu Arg Gln Lys Val Ala Glu
495 500 505 510
cag gag cga aca gct cag cag ctg cgg gca gag aag gcc agc tat gca 1584
Gln Glu Arg Thr Ala Gln Gln Leu Arg Ala Glu Lys Ala Ser Tyr Ala
515 520 525
gag cag ctg agc atg ctg aag aag gcg cat ggc ctg ctg gca gag gag 1632
Glu Gln Leu Ser Met Leu Lys Lys Ala His Gly Leu Leu Ala Glu Glu
530 535 540
aac cgg ggg ctg ggt gag cgg gcc aac ctt ggc cgg cag ttt ctg gaa 1680
Asn Arg Gly Leu Gly Glu Arg Ala Asn Leu Gly Arg Gln Phe Leu Glu
545 550 555
gtg gag ttg gac cag gcc cgg gag aag tat gtc caa gag ttg gca gcc 1728
Val Glu Leu Asp Gln Ala Arg Glu Lys Tyr Val Gln Glu Leu Ala Ala
560 565 570
gta cgt gct gat gct gag acc cgt ctg gct gag gtg cag cga gaa gca 1776
Val Arg Ala Asp Ala Glu Thr Arg Leu Ala Glu Val Gln Arg Glu Ala
575 580 585 590
cag agc act gcc cgg gag ctg gag gtg atg act gcc aag tat gag ggt 1824
Gln Ser Thr Ala Arg Glu Leu Glu Val Met Thr Ala Lys Tyr Glu Gly
595 600 605
gcc aag gtc aag gtc ctg gag gag agg cag cgg ttc cag gaa gag agg 1872
Ala Lys Val Lys Val Leu Glu Glu Arg Gln Arg Phe Gln Glu Glu Arg
610 615 620
cag aaa ctc act gcc cag gtg gaa gaa ctg agt aag aaa ctg gct gac 1920
Gln Lys Leu Thr Ala Gln Val Glu Glu Leu Ser Lys Lys Leu Ala Asp
625 630 635
tct gac caa gcc agc aag gtg cag cag cag aag ctg aag gct gtc cag 1968
Ser Asp Gln Ala Ser Lys Val Gln Gln Gln Lys Leu Lys Ala Val Gln
640 645 650
gct cag gga ggc gag agc cag cag gag gcc cag cgc ctc cag gcc cag 2016
Ala Gln Gly Gly Glu Ser Gln Gln Glu Ala Gln Arg Leu Gln Ala Gln
655 660 665 670
ctg aat gaa ctg caa gcc cag ttg agc cag aag gag cag gca gct gag 2064
Leu Asn Glu Leu Gln Ala Gln Leu Ser Gln Lys Glu Gln Ala Ala Glu
675 680 685
cac tat aag ctg cag atg gag aaa gcc aaa aca cat tat gat gcc aag 2112
His Tyr Lys Leu Gln Met Glu Lys Ala Lys Thr His Tyr Asp Ala Lys
690 695 700
aag cag cag aac caa gag ctg cag gag cag ctg cgg agc ctg gag cag 2160
Lys Gln Gln Asn Gln Glu Leu Gln Glu Gln Leu Arg Ser Leu Glu Gln
705 710 715
ctg cag aag gaa aac aaa gag ctg cga gct gaa gct gaa cgg ctg ggc 2208
Leu Gln Lys Glu Asn Lys Glu Leu Arg Ala Glu Ala Glu Arg Leu Gly
720 725 730
cat gag cta cag cag gct ggg ctg aag acc aag gag gct gaa cag acc 2256
His Glu Leu Gln Gln Ala Gly Leu Lys Thr Lys Glu Ala Glu Gln Thr
735 740 745 750
tgc cgc cac ctt act gcc cag gtg cgc agc ctg gag gca cag gtt gcc 2304
Cys Arg His Leu Thr Ala Gln Val Arg Ser Leu Glu Ala Gln Val Ala
755 760 765
cat gca gac cag cag ctt cga gac ctg ggc aaa ttc cag gtg gca act 2352
His Ala Asp Gln Gln Leu Arg Asp Leu Gly Lys Phe Gln Val Ala Thr
770 775 780
gat gct tta aag agc cgt gag ccc cag gct aag ccc cag ctg gac ttg 2400
Asp Ala Leu Lys Ser Arg Glu Pro Gln Ala Lys Pro Gln Leu Asp Leu
785 790 795
agt att gac agc ctg gat ctg agc tgc gag gag ggg acc cca ctc agt 2448
Ser Ile Asp Ser Leu Asp Leu Ser Cys Glu Glu Gly Thr Pro Leu Ser
800 805 810
atc acc agc aag ctg cct cgt acc cag cca gac ggc acc agc gtc cct 2496
Ile Thr Ser Lys Leu Pro Arg Thr Gln Pro Asp Gly Thr Ser Val Pro
815 820 825 830
gga gaa cca gcc tca cct atc tcc cag cgc ctg ccc ccc aag gta gaa 2544
Gly Glu Pro Ala Ser Pro Ile Ser Gln Arg Leu Pro Pro Lys Val Glu
835 840 845
tcc ctg gag agt ctc tac ttc act ccc atc cct gct cgg agt cag gcc 2592
Ser Leu Glu Ser Leu Tyr Phe Thr Pro Ile Pro Ala Arg Ser Gln Ala
850 855 860
ccc ctg gag agc agc ctg gac tcc ctg gga gac gtc ttc ctg gac tcg 2640
Pro Leu Glu Ser Ser Leu Asp Ser Leu Gly Asp Val Phe Leu Asp Ser
865 870 875
ggt cgt aag acc cgc tcc gct cgt cgg cgc acc acg cag atc atc aac 2688
Gly Arg Lys Thr Arg Ser Ala Arg Arg Arg Thr Thr Gln Ile Ile Asn
880 885 890
atc acc atg acc aag aag cta gat gtg gaa gag cca gac agc gcc aac 2736
Ile Thr Met Thr Lys Lys Leu Asp Val Glu Glu Pro Asp Ser Ala Asn
895 900 905 910
tca tcg ttc tac agc acg cgg tct gct cct gct tcc cag gct agc ctg 2784
Ser Ser Phe Tyr Ser Thr Arg Ser Ala Pro Ala Ser Gln Ala Ser Leu
915 920 925
cga gcc acc tcc tct act cag tct cta gct cgc ctg ggt tct ccc gat 2832
Arg Ala Thr Ser Ser Thr Gln Ser Leu Ala Arg Leu Gly Ser Pro Asp
930 935 940
tat ggc aac tca gcc ctg ctc agc ttg cct ggc tac cgc ccc acc act 2880
Tyr Gly Asn Ser Ala Leu Leu Ser Leu Pro Gly Tyr Arg Pro Thr Thr
945 950 955
cgc agt tct gct cgt cgt tcc cag gcc ggg gtg tcc agt ggg gcc cct 2928
Arg Ser Ser Ala Arg Arg Ser Gln Ala Gly Val Ser Ser Gly Ala Pro
960 965 970
cca gga agg aac agc ttc tac atg ggc act tgc cag gat gag cct gag 2976
Pro Gly Arg Asn Ser Phe Tyr Met Gly Thr Cys Gln Asp Glu Pro Glu
975 980 985 990
cag ctg gat gac tgg aac cgc att gca gag ctg cag cag cgc aat cga 3024
Gln Leu Asp Asp Trp Asn Arg Ile Ala Glu Leu Gln Gln Arg Asn Arg
995 1000 1005
gtg tgc ccc cca cat ctg aag acc tgc tat ccc ctg gag tcc agg cct 3072
Val Cys Pro Pro His Leu Lys Thr Cys Tyr Pro Leu Glu Ser Arg Pro
1010 1015 1020
tcc ctg agc ctg ggc acc atc aca gat gag gag atg aaa act gga gac 3120
Ser Leu Ser Leu Gly Thr Ile Thr Asp Glu Glu Met Lys Thr Gly Asp
1025 1030 1035
ccc caa gag acc ctg cgc cga gcc agc atg cag cca atc cag ata gcc 3168
Pro Gln Glu Thr Leu Arg Arg Ala Ser Met Gln Pro Ile Gln Ile Ala
1040 1045 1050
gag ggc act ggc atc acc acc cgg cag cag cgc aaa cgg gtc tcc cta 3216
Glu Gly Thr Gly Ile Thr Thr Arg Gln Gln Arg Lys Arg Val Ser Leu
1055 1060 1065 1070
gag ccc cac cag ggc cct gga act cct gag tct aag aag gcc acc agc 3264
Glu Pro His Gln Gly Pro Gly Thr Pro Glu Ser Lys Lys Ala Thr Ser
1075 1080 1085
tgt ttc cca cgc ccc atg act ccc cga gac cga cat gaa ggg cgc aaa 3312
Cys Phe Pro Arg Pro Met Thr Pro Arg Asp Arg His Glu Gly Arg Lys
1090 1095 1100
cag agc act act gag gcc cag aag aaa gca gct cca gct tct act aaa 3360
Gln Ser Thr Thr Glu Ala Gln Lys Lys Ala Ala Pro Ala Ser Thr Lys
1105 1110 1115
cag gct gac cgg cgc cag tcg atg gcc ttc agc atc ctc aac aca ccc 3408
Gln Ala Asp Arg Arg Gln Ser Met Ala Phe Ser Ile Leu Asn Thr Pro
1120 1125 1130
aag aag cta ggg aac agc ctt ctg cgg cgg gga gcc tca aag aag gcc 3456
Lys Lys Leu Gly Asn Ser Leu Leu Arg Arg Gly Ala Ser Lys Lys Ala
1135 1140 1145 1150
ctg tcc aag gct tcc ccc aac act cgc agt gga acc cgc cgt tct ccg 3504
Leu Ser Lys Ala Ser Pro Asn Thr Arg Ser Gly Thr Arg Arg Ser Pro
1155 1160 1165
cgc att gcc acc acc aca gcc agc gcc gcc act gct gcc gcc att ggt 3552
Arg Ile Ala Thr Thr Thr Ala Ser Ala Ala Thr Ala Ala Ala Ile Gly
1170 1175 1180
gcc acc cct cga gcc aag ggc aag gca aag cac taaag ggccagtacc 3600
Ala Thr Pro Arg Ala Lys Gly Lys Ala Lys His
1185 1190
agtgagtggc cccacctgtg tccccgatgc tgccgtcacc tggtcctccg cctactgtcc 3660
ctctcagtgc cttctctcag ctcccaggcc aacagtagcc aaacccctag agacagtgat 3720
gcctgcccgc accctggcct ggtccctggt ccttcactgg cgccttctcg gagctggccc 3780
agggggcctg gagcatggac agtgtgggcg ctctccctac cttgcctcct tttttcttaa 3840
agcaaagtca cttctccatc acaaccagat ttgaggctgg ttttgatggc tgggtccttg 3900
ggcctggcca gtcttcctct tagcctctgg atctagaagg gaccataaga ggagtaggcc 3960
ctggttcctg ctgtcctggt ggctgggccc agcaggggcc ctcactcttg aagtccagga 4020
ctgggtctga cctggtggga gcacctgcca gaggatgctc tttcccagga cggatgggcc 4080
ctgtgtctca ggagtggggt tgggggacag ccttcagcag cagctcacac cctaccttcc 4140
ccagacttgc actggggtgg gatttggagt gatgggaagg tttttaaggg ccggggatgg 4200
atcttttcta aatgttatta cttgtaaata aagtctattt ttctcccgtg aaaaaaaaaa 4260
aaaaaaccaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaaaaaaaaa aaa 4313
<210> 5
<211> 26926
<212> PRT
<213> Titin human protein
<400> 5
Met Thr Thr Gln Ala Pro Thr Phe Thr Gln Pro Leu Gln Ser Val Val
1 5 10 15
Val Leu Glu Gly Ser Thr Ala Thr Phe Glu Ala His Ile Ser Gly Phe
20 25 30
Pro Val Pro Glu Val Ser Trp Phe Arg Asp Gly Gln Val Ile Ser Thr
35 40 45
Ser Thr Leu Pro Gly Val Gln Ile Ser Phe Ser Asp Gly Arg Ala Lys
50 55 60
Leu Thr Ile Pro Ala Val Thr Lys Ala Asn Ser Gly Arg Tyr Ser Leu
65 70 75 80
Lys Ala Thr Asn Gly Ser Gly Gln Ala Thr Ser Thr Ala Glu Leu Leu
85 90 95
Val Lys Ala Glu Thr Ala Pro Pro Asn Phe Val Gln Arg Leu Gln Ser
100 105 110
Met Thr Val Arg Gln Gly Ser Gln Val Arg Leu Gln Val Arg Val Thr
115 120 125
Gly Ile Pro Asn Pro Val Val Lys Phe Tyr Arg Asp Gly Ala Glu Ile
130 135 140
Gln Ser Ser Leu Asp Phe Gln Ile Ser Gln Glu Gly Asp Leu Tyr Ser
145 150 155 160
Leu Leu Ile Ala Glu Ala Tyr Pro Glu Asp Ser Gly Thr Tyr Ser Val
165 170 175
Asn Ala Thr Asn Ser Val Gly Arg Ala Thr Ser Thr Ala Glu Leu Leu
180 185 190
Val Gln Gly Glu Glu Glu Val Pro Ala Lys Lys Thr Lys Thr Ile Val
195 200 205
Ser Thr Ala Gln Ile Ser Glu Ser Arg Gln Thr Arg Ile Glu Lys Lys
210 215 220
Ile Glu Ala His Phe Asp Ala Arg Ser Ile Ala Thr Val Glu Met Val
225 230 235 240
Ile Asp Gly Ala Ala Gly Gln Gln Leu Pro His Lys Thr Pro Pro Arg
245 250 255
Ile Pro Pro Lys Pro Lys Ser Arg Ser Pro Thr Pro Pro Ser Ile Ala
260 265 270
Ala Lys Ala Gln Leu Ala Arg Gln Gln Ser Pro Ser Pro Ile Arg His
275 280 285
Ser Pro Ser Pro Val Arg His Val Arg Ala Pro Thr Pro Ser Pro Val
290 295 300
Arg Ser Val Ser Pro Ala Ala Arg Ile Ser Thr Ser Pro Ile Arg Ser
305 310 315 320
Val Arg Ser Pro Leu Leu Met Arg Lys Thr Gln Ala Ser Thr Val Ala
325 330 335
Thr Gly Pro Glu Val Pro Pro Pro Trp Lys Gln Glu Gly Tyr Val Ala
340 345 350
Ser Ser Ser Glu Ala Glu Met Arg Glu Thr Thr Leu Thr Thr Ser Thr
355 360 365
Gln Ile Arg Thr Glu Glu Arg Trp Glu Gly Arg Tyr Gly Val Gln Glu
370 375 380
Gln Val Thr Ile Ser Gly Ala Ala Gly Ala Ala Ala Ser Val Ser Ala
385 390 395 400
Ser Ala Ser Tyr Ala Ala Glu Ala Val Ala Thr Gly Ala Lys Glu Val
405 410 415
Lys Gln Asp Ala Asp Lys Ser Ala Ala Val Ala Thr Val Val Ala Ala
420 425 430
Val Asp Met Ala Arg Val Arg Glu Pro Val Ile Ser Ala Val Glu Gln
435 440 445
Thr Ala Gln Arg Thr Thr Thr Thr Ala Val His Ile Gln Pro Ala Gln
450 455 460
Glu Gln Val Arg Lys Glu Ala Glu Lys Thr Ala Val Thr Lys Val Val
465 470 475 480
Val Ala Ala Asp Lys Ala Lys Glu Gln Glu Leu Lys Ser Arg Thr Lys
485 490 495
Glu Ile Ile Thr Thr Lys Gln Glu Gln Met His Val Thr His Glu Gln
500 505 510
Ile Arg Lys Glu Thr Glu Lys Thr Phe Val Pro Lys Val Val Ile Ser
515 520 525
Ala Ala Lys Ala Lys Glu Gln Glu Thr Arg Ile Ser Glu Glu Ile Thr
530 535 540
Lys Lys Gln Lys Gln Val Thr Gln Glu Ala Ile Met Lys Glu Thr Arg
545 550 555 560
Lys Thr Val Val Pro Lys Val Ile Val Ala Thr Pro Lys Val Lys Glu
565 570 575
Gln Asp Leu Val Ser Arg Gly Arg Glu Gly Ile Thr Thr Lys Arg Glu
580 585 590
Gln Val Gln Ile Thr Gln Glu Lys Met Arg Lys Glu Ala Glu Lys Thr
595 600 605
Ala Leu Ser Thr Ile Ala Val Ala Thr Ala Lys Ala Lys Glu Gln Glu
610 615 620
Thr Ile Leu Arg Thr Arg Glu Thr Met Ala Thr Arg Gln Glu Gln Ile
625 630 635 640
Gln Val Thr His Gly Lys Val Asp Val Gly Lys Lys Ala Glu Ala Val
645 650 655
Ala Thr Val Val Ala Ala Val Asp Gln Ala Arg Val Arg Glu Pro Arg
660 665 670
Glu Pro Gly His Leu Glu Glu Ser Tyr Ala Gln Gln Thr Thr Leu Glu
675 680 685
Tyr Gly Tyr Lys Glu Arg Ile Ser Ala Ala Lys Val Ala Glu Pro Pro
690 695 700
Gln Arg Pro Ala Ser Glu Pro His Val Val Pro Lys Ala Val Lys Pro
705 710 715 720
Arg Val Ile Gln Ala Pro Ser Glu Thr His Ile Lys Thr Thr Asp Gln
725 730 735
Lys Gly Met His Ile Ser Ser Gln Ile Lys Lys Thr Thr Asp Leu Thr
740 745 750
Thr Glu Arg Leu Val His Val Asp Lys Arg Pro Arg Thr Ala Ser Pro
755 760 765
His Phe Thr Val Ser Lys Ile Ser Val Pro Lys Thr Glu His Gly Tyr
770 775 780
Glu Ala Ser Ile Ala Gly Ser Ala Ile Ala Thr Leu Gln Lys Glu Leu
785 790 795 800
Ser Ala Thr Ser Ser Ala Gln Lys Ile Thr Lys Ser Val Lys Ala Pro
805 810 815
Thr Val Lys Pro Ser Glu Thr Arg Val Arg Ala Glu Pro Thr Pro Leu
820 825 830
Pro Gln Phe Pro Phe Ala Asp Thr Pro Asp Thr Tyr Lys Ser Glu Ala
835 840 845
Gly Val Glu Val Lys Lys Glu Val Gly Val Ser Ile Thr Gly Thr Thr
850 855 860
Val Arg Glu Glu Arg Phe Glu Val Leu His Gly Arg Glu Ala Lys Val
865 870 875 880
Thr Glu Thr Ala Arg Val Pro Ala Pro Val Glu Ile Pro Val Thr Pro
885 890 895
Pro Thr Leu Val Ser Gly Leu Lys Asn Val Thr Val Ile Glu Gly Glu
900 905 910
Ser Val Thr Leu Glu Cys His Ile Ser Gly Tyr Pro Ser Pro Thr Val
915 920 925
Thr Trp Tyr Arg Glu Asp Tyr Gln Ile Glu Ser Ser Ile Asp Phe Gln
930 935 940
Ile Thr Phe Gln Ser Gly Ile Ala Arg Leu Met Ile Arg Glu Ala Phe
945 950 955 960
Ala Glu Asp Ser Gly Arg Phe Thr Cys Ser Ala Val Asn Glu Ala Gly
965 970 975
Thr Val Ser Thr Ser Cys Tyr Leu Ala Val Gln Val Ser Glu Glu Phe
980 985 990
Glu Lys Glu Thr Thr Ala Val Thr Glu Lys Phe Thr Thr Glu Glu Lys
995 1000 1005
Arg Phe Val Glu Ser Arg Asp Val Val Met Thr Asp Thr Ser Leu Thr
1010 1015 1020
Glu Glu Gln Ala Gly Pro Gly Glu Pro Ala Ala Pro Tyr Phe Ile Thr
1025 1030 1035 1040
Lys Pro Val Val Gln Lys Leu Val Glu Gly Gly Ser Val Val Phe Gly
1045 1050 1055
Cys Gln Val Gly Gly Asn Pro Lys Pro His Val Tyr Trp Lys Lys Ser
1060 1065 1070
Gly Val Pro Leu Thr Thr Gly Tyr Arg Tyr Lys Val Ser Tyr Asn Lys
1075 1080 1085
Gln Thr Gly Glu Cys Lys Leu Val Ile Ser Met Thr Phe Ala Asp Asp
1090 1095 1100
Ala Gly Glu Tyr Thr Ile Val Val Arg Asn Lys His Gly Glu Thr Ser
1105 1110 1115 1120
Ala Ser Ala Ser Leu Leu Glu Glu Ala Asp Tyr Glu Leu Leu Met Lys
1125 1130 1135
Ser Gln Gln Glu Met Leu Tyr Gln Thr Gln Val Thr Ala Phe Val Gln
1140 1145 1150
Glu Pro Glu Val Gly Glu Thr Ala Pro Gly Phe Val Tyr Ser Glu Tyr
1155 1160 1165
Glu Lys Glu Tyr Glu Lys Glu Gln Ala Leu Ile Arg Lys Lys Met Ala
1170 1175 1180
Lys Asp Thr Val Val Val Arg Thr Tyr Val Glu Asp Gln Glu Phe His
1185 1190 1195 1200
Ile Ser Ser Phe Glu Glu Arg Leu Ile Lys Glu Ile Glu Tyr Arg Ile
1205 1210 1215
Ile Lys Thr Thr Leu Glu Glu Leu Leu Glu Glu Asp Gly Glu Glu Lys
1220 1225 1230
Met Ala Val Asp Ile Ser Glu Ser Glu Ala Val Glu Ser Gly Phe Asp
1235 1240 1245
Leu Arg Ile Lys Asn Tyr Arg Ile Leu Glu Gly Met Gly Val Thr Phe
1250 1255 1260
His Cys Lys Met Ser Gly Tyr Pro Leu Pro Lys Ile Ala Trp Tyr Lys
1265 1270 1275 1280
Asp Gly Lys Arg Ile Lys His Gly Glu Arg Tyr Gln Met Asp Phe Leu
1285 1290 1295
Gln Asp Gly Arg Ala Ser Leu Arg Ile Pro Val Val Leu Pro Glu Asp
1300 1305 1310
Glu Gly Ile Tyr Thr Ala Phe Ala Ser Asn Ile Lys Gly Asn Ala Ile
1315 1320 1325
Cys Ser Gly Lys Leu Tyr Val Glu Pro Ala Ala Pro Leu Gly Ala Pro
1330 1335 1340
Thr Tyr Ile Pro Thr Leu Glu Pro Val Ser Arg Ile Arg Ser Leu Ser
1345 1350 1355 1360
Pro Arg Ser Val Ser Arg Ser Pro Ile Arg Met Ser Pro Ala Arg Met
1365 1370 1375
Ser Pro Ala Arg Met Ser Pro Ala Arg Met Ser Pro Ala Arg Met Ser
1380 1385 1390
Pro Gly Arg Arg Leu Glu Glu Thr Asp Glu Ser Gln Leu Glu Arg Leu
1395 1400 1405
Tyr Lys Pro Val Phe Val Leu Lys Pro Val Ser Phe Lys Cys Leu Glu
1410 1415 1420
Gly Ala Asn Cys Arg Phe Asp Leu Lys Val Val Gly Arg Pro Met Pro
1425 1430 1435 1440
Glu Thr Phe Trp Phe His Asp Gly Gln Gln Ile Val Asn Asp Tyr Thr
1445 1450 1455
His Lys Val Val Ile Lys Glu Asp Gly Thr Gln Ser Leu Ile Ile Val
1460 1465 1470
Pro Ala Thr Pro Ser Asp Ser Gly Glu Trp Thr Val Val Ala Gln Asn
1475 1480 1485
Arg Ala Gly Arg Ser Ser Ile Ser Val Ile Leu Thr Val Glu Ala Val
1490 1495 1500
Glu His Gln Val Lys Pro Met Phe Val Glu Lys Leu Lys Asn Val Asn
1505 1510 1515 1520
Ile Lys Glu Gly Ser Arg Leu Glu Met Lys Val Arg Ala Thr Gly Asn
1525 1530 1535
Pro Asn Pro Asp Ile Val Trp Leu Lys Asn Ser Asp Ile Ile Val Pro
1540 1545 1550
His Lys Tyr Pro Lys Ile Arg Ile Glu Gly Thr Lys Gly Glu Ala Ala
1555 1560 1565
Leu Lys Ile Asp Ser Thr Val Ser Gln Asp Ser Ala Trp Tyr Thr Ala
1570 1575 1580
Thr Ala Ile Asn Lys Ala Gly Arg Asp Thr Thr Arg Cys Lys Val Asn
1585 1590 1595 1600
Val Glu Val Glu Phe Ala Glu Pro Glu Pro Glu Arg Lys Leu Ile Ile
1605 1610 1615
Pro Arg Gly Thr Tyr Arg Ala Lys Glu Ile Ala Ala Pro Glu Leu Glu
1620 1625 1630
Pro Leu His Leu Arg Tyr Gly Gln Glu Gln Trp Glu Glu Gly Asp Leu
1635 1640 1645
Tyr Asp Lys Glu Lys Gln Gln Lys Pro Phe Phe Lys Lys Lys Leu Thr
1650 1655 1660
Ser Leu Arg Leu Lys Arg Phe Gly Pro Ala His Phe Glu Cys Arg Leu
1665 1670 1675 1680
Thr Pro Ile Ser Asp Pro Thr Met Val Val Glu Trp Leu His Asp Gly
1685 1690 1695
Lys Pro Leu Glu Ala Ala Asn Arg Leu Arg Met Ile Asn Glu Phe Gly
1700 1705 1710
Tyr Cys Ser Leu Asp Tyr Gly Val Ala Tyr Ser Arg Asp Ser Gly Ile
1715 1720 1725
Ile Thr Cys Arg Ala Thr Asn Lys Tyr Gly Thr Asp His Thr Ser Ala
1730 1735 1740
Thr Leu Ile Val Lys Asp Glu Lys Ser Leu Val Glu Glu Ser Gln Leu
1745 1750 1755 1760
Pro Glu Gly Arg Lys Gly Leu Gln Arg Ile Glu Glu Leu Glu Arg Met
1765 1770 1775
Ala His Glu Gly Ala Leu Thr Gly Val Thr Thr Asp Gln Lys Glu Lys
1780 1785 1790
Gln Lys Pro Asp Ile Val Leu Tyr Pro Glu Pro Val Arg Val Leu Glu
1795 1800 1805
Gly Glu Thr Ala Arg Phe Arg Cys Arg Val Thr Gly Tyr Pro Gln Pro
1810 1815 1820
Lys Val Asn Trp Tyr Leu Asn Gly Gln Leu Ile Arg Lys Ser Lys Arg
1825 1830 1835 1840
Phe Arg Val Arg Tyr Asp Gly Ile His Tyr Leu Asp Ile Val Asp Cys
1845 1850 1855
Lys Ser Tyr Asp Thr Gly Glu Val Lys Val Thr Ala Glu Asn Pro Glu
1860 1865 1870
Gly Val Ile Glu His Lys Val Lys Leu Glu Ile Gln Gln Arg Glu Asp
1875 1880 1885
Phe Arg Ser Val Leu Arg Arg Ala Pro Glu Pro Arg Pro Glu Phe His
1890 1895 1900
Val His Glu Pro Gly Lys Leu Gln Phe Glu Val Gln Lys Val Asp Arg
1905 1910 1915 1920
Pro Val Asp Thr Thr Glu Thr Lys Glu Val Val Lys Leu Lys Arg Ala
1925 1930 1935
Glu Arg Ile Thr His Glu Lys Val Pro Glu Glu Ser Glu Glu Leu Arg
1940 1945 1950
Ser Lys Phe Lys Arg Arg Thr Glu Glu Gly Tyr Tyr Glu Ala Ile Thr
1955 1960 1965
Ala Val Glu Leu Lys Ser Arg Lys Lys Asp Glu Ser Tyr Glu Glu Leu
1970 1975 1980
Leu Arg Lys Thr Lys Asp Glu Leu Leu His Trp Thr Lys Glu Leu Thr
1985 1990 1995 2000
Glu Glu Glu Lys Lys Ala Leu Ala Glu Glu Gly Lys Ile Thr Ile Pro
2005 2010 2015
Thr Phe Lys Pro Asp Lys Ile Glu Leu Ser Pro Ser Met Glu Ala Pro
2020 2025 2030
Lys Ile Phe Glu Arg Ile Gln Ser Gln Thr Val Gly Gln Gly Ser Asp
2035 2040 2045
Ala His Phe Arg Val Arg Val Val Gly Lys Pro Asp Pro Glu Cys Glu
2050 2055 2060
Trp Tyr Lys Asn Gly Val Lys Ile Glu Arg Ser Asp Arg Ile Tyr Trp
2065 2070 2075 2080
Tyr Trp Pro Glu Asp Asn Val Cys Glu Leu Val Ile Arg Asp Val Thr
2085 2090 2095
Ala Glu Asp Ser Ala Ser Ile Met Val Lys Ala Ile Asn Ile Ala Gly
2100 2105 2110
Glu Thr Ser Ser His Ala Phe Leu Leu Val Gln Ala Lys Gln Leu Ile
2115 2120 2125
Thr Phe Thr Gln Glu Leu Gln Asp Val Val Ala Lys Glu Lys Asp Thr
2130 2135 2140
Met Ala Thr Phe Glu Cys Glu Thr Ser Glu Pro Phe Val Lys Val Lys
2145 2150 2155 2160
Trp Tyr Lys Asp Gly Met Glu Val His Glu Gly Asp Lys Tyr Arg Met
2165 2170 2175
His Ser Asp Arg Lys Val His Phe Leu Ser Ile Leu Thr Ile Asp Thr
2180 2185 2190
Ser Asp Ala Glu Asp Tyr Ser Cys Val Leu Val Glu Asp Glu Asn Val
2195 2200 2205
Lys Thr Thr Ala Lys Leu Ile Val Glu Gly Ala Val Val Glu Phe Val
2210 2215 2220
Lys Glu Leu Gln Asp Ile Glu Val Pro Glu Ser Tyr Ser Gly Glu Leu
2225 2230 2235 2240
Glu Cys Ile Val Ser Pro Glu Asn Ile Glu Gly Lys Trp Tyr His Asn
2245 2250 2255
Asp Val Glu Leu Lys Ser Asn Gly Lys Tyr Thr Ile Thr Ser Arg Arg
2260 2265 2270
Gly Arg Gln Asn Leu Thr Val Lys Asp Val Thr Lys Glu Asp Gln Gly
2275 2280 2285
Glu Tyr Ser Phe Val Ile Asp Gly Lys Lys Thr Thr Cys Lys Leu Lys
2290 2295 2300
Met Lys Pro Arg Pro Ile Ala Ile Leu Gln Gly Leu Ser Asp Gln Lys
2305 2310 2315 2320
Val Cys Glu Gly Asp Ile Val Gln Leu Glu Val Lys Val Ser Leu Glu
2325 2330 2335
Ser Val Glu Gly Val Trp Met Lys Asp Gly Gln Glu Val Gln Pro Ser
2340 2345 2350
Asp Arg Val His Ile Val Ile Asp Lys Gln Ser His Met Leu Leu Ile
2355 2360 2365
Glu Asp Met Thr Lys Glu Asp Ala Gly Asn Tyr Ser Phe Thr Ile Pro
2370 2375 2380
Ala Leu Gly Leu Ser Thr Ser Gly Arg Val Ser Val Tyr Ser Val Asp
2385 2390 2395 2400
Val Ile Thr Pro Leu Lys Asp Val Asn Val Ile Glu Gly Thr Lys Ala
2405 2410 2415
Val Leu Glu Cys Lys Val Ser Val Pro Asp Val Thr Ser Val Lys Trp
2420 2425 2430
Tyr Leu Asn Asp Glu Gln Ile Lys Pro Asp Asp Arg Val Gln Ala Ile
2435 2440 2445
Val Lys Gly Thr Lys Gln Arg Leu Val Ile Asn Arg Thr His Ala Ser
2450 2455 2460
Asp Glu Gly Pro Tyr Lys Leu Ile Val Gly Arg Val Glu Thr Asn Cys
2465 2470 2475 2480
Asn Leu Ser Val Glu Lys Ile Lys Ile Ile Arg Gly Leu Arg Asp Leu
2485 2490 2495
Thr Cys Thr Glu Thr Gln Asn Val Val Phe Glu Val Glu Leu Ser His
2500 2505 2510
Ser Gly Ile Asp Val Leu Trp Asn Phe Lys Asp Lys Glu Ile Lys Pro
2515 2520 2525
Ser Ser Lys Tyr Lys Ile Glu Ala His Gly Lys Ile Tyr Lys Leu Thr
2530 2535 2540
Val Leu Asn Met Met Lys Asp Asp Glu Gly Lys Tyr Thr Phe Tyr Ala
2545 2550 2555 2560
Gly Glu Asn Met Thr Ser Gly Lys Leu Thr Val Ala Gly Gly Ala Ile
2565 2570 2575
Ser Lys Pro Leu Thr Asp Gln Thr Val Ala Glu Ser Gln Glu Ala Val
2580 2585 2590
Phe Glu Cys Glu Val Ala Asn Pro Asp Ser Lys Gly Glu Trp Leu Arg
2595 2600 2605
Asp Gly Lys His Leu Pro Leu Thr Asn Asn Ile Arg Ser Glu Ser Asp
2610 2615 2620
Gly His Lys Arg Arg Leu Ile Ile Ala Ala Thr Lys Leu Asp Asp Ile
2625 2630 2635 2640
Gly Glu Tyr Thr Tyr Lys Val Ala Thr Ser Lys Thr Ser Ala Lys Leu
2645 2650 2655
Lys Val Glu Ala Val Lys Ile Lys Lys Thr Leu Lys Asn Leu Thr Val
2660 2665 2670
Thr Glu Thr Gln Asp Ala Val Phe Thr Val Glu Leu Thr His Pro Asn
2675 2680 2685
Val Lys Gly Val Gln Trp Ile Lys Asn Gly Val Val Leu Glu Ser Asn
2690 2695 2700
Glu Lys Tyr Ala Ile Ser Val Lys Gly Thr Ile Tyr Ser Leu Arg Ile
2705 2710 2715 2720
Lys Asn Cys Ala Ile Val Asp Glu Ser Val Tyr Gly Phe Arg Leu Gly
2725 2730 2735
Arg Leu Gly Ala Ser Ala Arg Leu His Val Glu Thr Val Lys Ile Ile
2740 2745 2750
Lys Lys Pro Lys Asp Val Thr Ala Leu Glu Asn Ala Thr Val Ala Phe
2755 2760 2765
Glu Val Ser Val Ser His Asp Thr Val Pro Val Lys Trp Phe His Lys
2770 2775 2780
Ser Val Glu Ile Lys Pro Ser Asp Lys His Arg Leu Val Ser Glu Arg
2785 2790 2795 2800
Lys Val His Lys Leu Met Leu Gln Asn Ile Ser Pro Ser Asp Ala Gly
2805 2810 2815
Glu Tyr Thr Ala Val Val Gly Gln Leu Glu Cys Lys Ala Lys Leu Phe
2820 2825 2830
Val Glu Thr Leu His Ile Thr Lys Thr Met Lys Asn Ile Glu Val Pro
2835 2840 2845
Glu Thr Lys Thr Ala Ser Phe Glu Cys Glu Val Ser His Phe Asn Val
2850 2855 2860
Pro Ser Met Trp Leu Lys Asn Gly Val Glu Ile Glu Met Ser Glu Lys
2865 2870 2875 2880
Phe Lys Ile Val Val Gln Gly Lys Leu His Gln Leu Ile Ile Met Asn
2885 2890 2895
Thr Ser Thr Glu Asp Ser Ala Glu Tyr Thr Phe Val Cys Gly Asn Asp
2900 2905 2910
Gln Val Ser Ala Thr Leu Thr Val Thr Pro Ile Met Ile Thr Ser Met
2915 2920 2925
Leu Lys Asp Ile Asn Ala Glu Glu Lys Asp Thr Ile Thr Phe Glu Val
2930 2935 2940
Thr Val Asn Tyr Glu Gly Ile Ser Tyr Lys Trp Leu Lys Asn Gly Val
2945 2950 2955 2960
Glu Ile Lys Ser Thr Asp Lys Cys Gln Met Arg Thr Lys Lys Leu Thr
2965 2970 2975
His Ser Leu Asn Ile Arg Asn Val His Phe Gly Asp Ala Ala Asp Tyr
2980 2985 2990
Thr Phe Val Ala Gly Lys Ala Thr Ser Thr Ala Thr Leu Tyr Val Glu
2995 3000 3005
Ala Arg His Ile Glu Phe Arg Lys His Ile Lys Asp Ile Lys Val Leu
3010 3015 3020
Glu Lys Lys Arg Ala Met Phe Glu Cys Glu Val Ser Glu Pro Asp Ile
3025 3030 3035 3040
Thr Val Gln Trp Met Lys Asp Asp Gln Glu Leu Gln Ile Thr Asp Arg
3045 3050 3055
Ile Lys Ile Gln Lys Glu Lys Tyr Val His Arg Leu Leu Ile Pro Ser
3060 3065 3070
Thr Arg Met Ser Asp Ala Gly Lys Tyr Thr Val Val Ala Gly Gly Asn
3075 3080 3085
Val Ser Thr Ala Lys Leu Phe Val Glu Gly Arg Asp Val Arg Ile Arg
3090 3095 3100
Ser Ile Lys Lys Glu Val Gln Val Ile Glu Lys Gln Arg Ala Val Val
3105 3110 3115 3120
Glu Phe Glu Val Asn Glu Asp Asp Val Asp Ala His Trp Tyr Lys Asp
3125 3130 3135
Gly Ile Glu Ile Asn Phe Gln Val Gln Glu Arg His Lys Tyr Val Val
3140 3145 3150
Glu Arg Arg Ile His Arg Met Phe Ile Ser Glu Thr Arg Gln Ser Asp
3155 3160 3165
Ala Gly Glu Tyr Thr Phe Val Ala Gly Arg Asn Arg Ser Ser Val Thr
3170 3175 3180
Leu Tyr Val Asn Ala Pro Glu Pro Pro Gln Val Leu Gln Glu Leu Gln
3185 3190 3195 3200
Pro Val Thr Val Gln Ser Gly Lys Pro Ala Arg Phe Cys Ala Met Ile
3205 3210 3215
Ser Gly Arg Pro Gln Pro Lys Ile Ser Trp Tyr Lys Glu Glu Gln Leu
3220 3225 3230
Leu Ser Thr Gly Phe Lys Cys Lys Phe Leu His Asp Gly Gln Glu Tyr
3235 3240 3245
Thr Leu Leu Leu Ile Glu Ala Phe Pro Glu Asp Ala Ala Val Tyr Thr
3250 3255 3260
Cys Glu Ala Lys Asn Asp Tyr Gly Val Ala Thr Thr Ser Ala Ser Leu
3265 3270 3275 3280
Ser Val Glu Val Pro Glu Val Val Ser Pro Asp Gln Glu Met Pro Val
3285 3290 3295
Tyr Pro Pro Ala Ile Ile Thr Pro Leu Gln Asp Thr Val Thr Ser Glu
3300 3305 3310
Gly Gln Pro Ala Arg Phe Gln Cys Arg Val Ser Gly Thr Asp Leu Lys
3315 3320 3325
Val Ser Trp Tyr Ser Lys Asp Lys Lys Ile Lys Pro Ser Arg Phe Phe
3330 3335 3340
Arg Met Thr Gln Phe Glu Asp Thr Tyr Gln Leu Glu Ile Ala Glu Ala
3345 3350 3355 3360
Tyr Pro Glu Asp Glu Gly Thr Tyr Thr Phe Val Ala Asn Asn Ala Val
3365 3370 3375
Gly Gln Val Ser Ser Thr Ala Asn Leu Ser Leu Glu Ala Pro Glu Ser
3380 3385 3390
Ile Leu His Glu Arg Ile Glu Gln Glu Ile Glu Met Glu Met Lys Glu
3395 3400 3405
Phe Ser Ser Ser Phe Leu Ser Ala Glu Glu Glu Gly Leu His Ser Ala
3410 3415 3420
Glu Leu Gln Leu Ser Lys Ile Asn Glu Thr Leu Glu Leu Leu Ser Glu
3425 3430 3435 3440
Ser Pro Val Tyr Pro Thr Lys Phe Asp Ser Glu Lys Glu Gly Thr Gly
3445 3450 3455
Pro Ile Phe Ile Lys Glu Val Ser Asn Ala Asp Ile Ser Met Gly Asp
3460 3465 3470
Val Ala Thr Leu Ser Val Thr Val Ile Gly Ile Pro Lys Pro Lys Ile
3475 3480 3485
Gln Trp Phe Phe Asn Gly Val Leu Leu Thr Pro Ser Ala Asp Tyr Lys
3490 3495 3500
Phe Val Phe Asp Gly Asp Asp His Ser Leu Ile Ile Leu Phe Thr Lys
3505 3510 3515 3520
Leu Glu Asp Glu Gly Glu Tyr Thr Cys Met Ala Ser Asn Asp Tyr Gly
3525 3530 3535
Lys Thr Ile Cys Ser Ala Tyr Leu Lys Ile Asn Ser Lys Gly Glu Gly
3540 3545 3550
His Lys Asp Thr Glu Thr Glu Ser Ala Val Ala Lys Ser Leu Glu Lys
3555 3560 3565
Leu Gly Gly Pro Cys Pro Pro His Phe Leu Lys Glu Leu Lys Pro Ile
3570 3575 3580
Arg Cys Ala Gln Gly Leu Pro Ala Ile Phe Glu Tyr Thr Val Val Gly
3585 3590 3595 3600
Glu Pro Ala Pro Thr Val Thr Trp Phe Lys Glu Asn Lys Gln Leu Cys
3605 3610 3615
Thr Ser Val Tyr Tyr Thr Ile Ile His Asn Pro Asn Gly Ser Gly Thr
3620 3625 3630
Phe Ile Val Asn Asp Pro Gln Arg Glu Asp Ser Gly Leu Tyr Ile Cys
3635 3640 3645
Lys Ala Glu Asn Met Leu Gly Glu Ser Thr Cys Ala Ala Glu Leu Leu
3650 3655 3660
Val Leu Leu Glu Asp Thr Asp Met Thr Asp Thr Pro Cys Lys Ala Lys
3665 3670 3675 3680
Ser Thr Pro Glu Ala Pro Glu Asp Phe Pro Gln Thr Pro Leu Lys Gly
3685 3690 3695
Pro Ala Val Glu Ala Leu Asp Ser Glu Gln Glu Ile Ala Thr Phe Val
3700 3705 3710
Lys Asp Thr Ile Leu Lys Ala Ala Leu Ile Thr Glu Glu Asn Gln Gln
3715 3720 3725
Leu Ser Tyr Glu His Ile Ala Lys Ala Asn Glu Leu Ser Ser Gln Leu
3730 3735 3740
Pro Leu Gly Ala Gln Glu Leu Gln Ser Ile Leu Glu Gln Asp Lys Leu
3745 3750 3755 3760
Thr Pro Glu Ser Thr Arg Glu Phe Leu Cys Ile Asn Gly Ser Ile His
3765 3770 3775
Phe Gln Pro Leu Lys Glu Pro Ser Pro Asn Leu Gln Leu Gln Ile Val
3780 3785 3790
Gln Ser Gln Lys Thr Phe Ser Lys Glu Gly Ile Leu Met Pro Glu Glu
3795 3800 3805
Pro Glu Thr Gln Ala Val Leu Ser Asp Thr Glu Lys Ile Phe Pro Ser
3810 3815 3820
Ala Met Ser Ile Glu Gln Ile Asn Ser Leu Thr Val Glu Pro Leu Lys
3825 3830 3835 3840
Thr Leu Leu Ala Glu Pro Glu Gly Asn Tyr Pro Gln Ser Ser Ile Glu
3845 3850 3855
Pro Pro Met His Ser Tyr Leu Thr Ser Val Ala Glu Glu Val Leu Ser
3860 3865 3870
Leu Lys Glu Lys Thr Val Ser Asp Thr Asn Arg Glu Gln Arg Val Thr
3875 3880 3885
Leu Gln Lys Gln Glu Ala Gln Ser Ala Leu Ile Leu Ser Gln Ser Leu
3890 3895 3900
Ala Glu Gly His Val Glu Ser Leu Gln Ser Pro Asp Val Met Ile Ser
3905 3910 3915 3920
Gln Val Asn Tyr Glu Pro Leu Val Pro Ser Glu His Ser Cys Thr Glu
3925 3930 3935
Gly Gly Lys Ile Leu Ile Glu Ser Ala Asn Pro Leu Glu Asn Ala Gly
3940 3945 3950
Gln Asp Ser Ala Val Arg Ile Glu Glu Gly Lys Ser Leu Arg Phe Pro
3955 3960 3965
Leu Ala Leu Glu Glu Lys Gln Val Leu Leu Lys Glu Glu His Ser Asp
3970 3975 3980
Asn Val Val Met Pro Pro Asp Gln Ile Ile Glu Ser Lys Arg Glu Pro
3985 3990 3995 4000
Val Ala Ile Lys Lys Val Gln Glu Val Gln Gly Arg Asp Leu Leu Ser
4005 4010 4015
Lys Glu Ser Leu Leu Ser Gly Ile Pro Glu Glu Gln Arg Leu Asn Leu
4020 4025 4030
Lys Ile Gln Ile Cys Arg Ala Leu Gln Ala Ala Val Ala Ser Glu Gln
4035 4040 4045
Pro Gly Leu Phe Ser Glu Trp Leu Arg Asn Ile Glu Lys Val Glu Val
4050 4055 4060
Glu Ala Val Asn Ile Thr Gln Glu Pro Arg His Ile Met Cys Met Tyr
4065 4070 4075 4080
Leu Val Thr Ser Ala Lys Ser Val Thr Glu Glu Val Thr Ile Ile Ile
4085 4090 4095
Glu Asp Val Asp Pro Gln Met Ala Asn Leu Lys Met Glu Leu Arg Asp
4100 4105 4110
Ala Leu Cys Ala Ile Ile Tyr Glu Glu Ile Asp Ile Leu Thr Ala Glu
4115 4120 4125
Gly Pro Arg Ile Gln Gln Gly Ala Lys Thr Ser Leu Gln Glu Glu Met
4130 4135 4140
Asp Ser Phe Ser Gly Ser Gln Lys Val Glu Pro Ile Thr Glu Pro Glu
4145 4150 4155 4160
Val Glu Ser Lys Tyr Leu Ile Ser Thr Glu Glu Val Ser Tyr Phe Asn
4165 4170 4175
Val Gln Ser Arg Val Lys Tyr Leu Asp Ala Thr Pro Val Thr Lys Gly
4180 4185 4190
Val Ala Ser Ala Val Val Ser Asp Glu Lys Gln Asp Glu Ser Leu Lys
4195 4200 4205
Pro Ser Glu Glu Lys Glu Glu Ser Ser Ser Glu Ser Gly Thr Glu Glu
4210 4215 4220
Val Ala Thr Val Lys Ile Gln Glu Ala Glu Gly Gly Leu Ile Lys Glu
4225 4230 4235 4240
Asp Gly Pro Met Ile His Thr Pro Leu Val Asp Thr Val Ser Glu Glu
4245 4250 4255
Gly Asp Ile Val His Leu Thr Thr Ser Ile Thr Asn Ala Lys Glu Val
4260 4265 4270
Asn Trp Tyr Phe Glu Asn Lys Leu Val Pro Ser Asp Glu Lys Phe Lys
4275 4280 4285
Cys Leu Gln Asp Gln Asn Thr Tyr Thr Leu Val Ile Asp Lys Val Asn
4290 4295 4300
Thr Glu Asp His Gln Gly Glu Tyr Val Cys Glu Ala Leu Asn Asp Ser
4305 4310 4315 4320
Gly Lys Thr Ala Thr Ser Ala Lys Leu Thr Val Val Lys Arg Ala Ala
4325 4330 4335
Pro Val Ile Lys Arg Lys Ile Glu Pro Leu Glu Val Ala Leu Gly His
4340 4345 4350
Leu Ala Lys Phe Thr Cys Glu Ile Gln Ser Ala Pro Asn Val Arg Phe
4355 4360 4365
Gln Trp Phe Lys Ala Gly Arg Glu Ile Tyr Glu Ser Asp Lys Cys Ser
4370 4375 4380
Ile Arg Ser Ser Lys Tyr Ile Ser Ser Leu Glu Ile Leu Arg Thr Gln
4385 4390 4395 4400
Val Val Asp Cys Gly Glu Tyr Thr Cys Lys Ala Ser Asn Glu Tyr Gly
4405 4410 4415
Ser Val Ser Cys Thr Ala Thr Leu Thr Val Thr Val Pro Gly Gly Glu
4420 4425 4430
Lys Lys Val Arg Lys Leu Leu Pro Glu Arg Lys Pro Glu Pro Lys Glu
4435 4440 4445
Glu Val Val Leu Lys Ser Val Leu Arg Lys Arg Pro Glu Glu Glu Glu
4450 4455 4460
Pro Lys Val Glu Pro Lys Lys Leu Glu Lys Val Lys Lys Pro Ala Val
4465 4470 4475 4480
Pro Glu Pro Pro Pro Pro Lys Pro Val Glu Glu Val Glu Val Pro Thr
4485 4490 4495
Val Thr Lys Arg Glu Arg Lys Ile Pro Glu Pro Thr Lys Val Pro Glu
4500 4505 4510
Ile Lys Pro Ala Ile Pro Leu Pro Ala Pro Glu Pro Lys Pro Lys Pro
4515 4520 4525
Glu Ala Glu Val Lys Thr Ile Lys Pro Pro Pro Val Glu Pro Glu Pro
4530 4535 4540
Thr Pro Ile Ala Ala Pro Val Thr Val Pro Val Val Gly Lys Lys Ala
4545 4550 4555 4560
Glu Ala Lys Ala Pro Lys Glu Glu Ala Ala Lys Pro Lys Gly Pro Ile
4565 4570 4575
Lys Gly Val Pro Lys Lys Thr Pro Ser Pro Ile Glu Ala Glu Arg Arg
4580 4585 4590
Lys Leu Arg Pro Gly Ser Gly Gly Glu Lys Pro Pro Asp Glu Ala Pro
4595 4600 4605
Phe Thr Tyr Gln Leu Lys Ala Val Pro Leu Lys Phe Val Lys Glu Ile
4610 4615 4620
Lys Asp Ile Ile Leu Thr Glu Ser Glu Phe Val Gly Ser Ser Ala Ile
4625 4630 4635 4640
Phe Glu Cys Leu Val Ser Pro Ser Thr Ala Ile Thr Thr Trp Met Lys
4645 4650 4655
Asp Gly Ser Asn Ile Arg Glu Ser Pro Lys His Arg Phe Ile Ala Asp
4660 4665 4670
Gly Lys Asp Arg Lys Leu His Ile Ile Asp Val Gln Leu Ser Asp Ala
4675 4680 4685
Gly Glu Tyr Thr Cys Val Leu Arg Leu Gly Asn Lys Glu Lys Thr Ser
4690 4695 4700
Thr Ala Lys Leu Val Val Glu Glu Leu Pro Val Arg Phe Val Lys Thr
4705 4710 4715 4720
Leu Glu Glu Glu Val Thr Val Val Lys Gly Gln Pro Leu Tyr Leu Ser
4725 4730 4735
Cys Glu Leu Asn Lys Glu Arg Asp Val Val Trp Arg Lys Asp Gly Lys
4740 4745 4750
Ile Val Val Glu Lys Pro Gly Arg Ile Val Pro Gly Val Ile Gly Leu
4755 4760 4765
Met Arg Ala Leu Thr Ile Asn Asp Ala Asp Asp Thr Asp Ala Gly Thr
4770 4775 4780
Tyr Thr Val Thr Val Glu Asn Ala Asn Asn Leu Glu Cys Ser Ser Cys
4785 4790 4795 4800
Val Lys Val Val Glu Val Ile Arg Asp Trp Leu Val Lys Pro Ile Arg
4805 4810 4815
Asp Gln His Val Lys Pro Lys Gly Thr Ala Ile Phe Ala Cys Asp Ile
4820 4825 4830
Ala Lys Asp Thr Pro Asn Ile Lys Trp Phe Lys Gly Tyr Asp Glu Ile
4835 4840 4845
Pro Ala Glu Pro Asn Asp Lys Thr Glu Ile Leu Arg Asp Gly Asn His
4850 4855 4860
Leu Tyr Leu Lys Ile Lys Asn Ala Met Pro Glu Asp Ile Ala Glu Tyr
4865 4870 4875 4880
Ala Val Glu Ile Glu Gly Lys Arg Tyr Pro Ala Lys Leu Thr Leu Gly
4885 4890 4895
Glu Arg Glu Val Glu Leu Leu Lys Pro Ile Glu Asp Val Thr Ile Tyr
4900 4905 4910
Glu Lys Glu Ser Ala Ser Phe Asp Ala Glu Ile Ser Glu Ala Asp Ile
4915 4920 4925
Pro Gly Gln Trp Lys Leu Lys Gly Glu Leu Leu Arg Pro Ser Pro Thr
4930 4935 4940
Cys Glu Ile Lys Ala Glu Gly Gly Lys Arg Phe Leu Thr Leu His Lys
4945 4950 4955 4960
Val Lys Leu Asp Gln Ala Gly Glu Val Leu Tyr Gln Ala Leu Asn Ala
4965 4970 4975
Ile Thr Thr Ala Ile Leu Thr Val Lys Glu Ile Glu Leu Asp Phe Ala
4980 4985 4990
Val Pro Leu Lys Asp Val Thr Val Pro Glu Arg Arg Gln Ala Arg Phe
4995 5000 5005
Glu Cys Val Leu Thr Arg Glu Ala Asn Val Ile Trp Ser Lys Gly Pro
5010 5015 5020
Asp Ile Ile Lys Ser Ser Asp Lys Phe Asp Ile Ile Ala Asp Gly Lys
5025 5030 5035 5040
Lys His Ile Leu Val Ile Asn Asp Ser Gln Phe Asp Asp Glu Gly Val
5045 5050 5055
Tyr Thr Ala Glu Val Glu Gly Lys Lys Thr Ser Ala Arg Leu Phe Val
5060 5065 5070
Thr Gly Ile Arg Leu Lys Phe Met Ser Pro Leu Glu Asp Gln Thr Val
5075 5080 5085
Lys Glu Gly Glu Thr Ala Thr Phe Val Cys Glu Leu Ser His Glu Lys
5090 5095 5100
Met His Val Val Trp Phe Lys Asn Asp Ala Lys Leu His Thr Ser Arg
5105 5110 5115 5120
Thr Val Leu Ile Ser Ser Glu Gly Lys Thr His Lys Leu Glu Met Lys
5125 5130 5135
Glu Val Thr Leu Asp Asp Ile Ser Gln Ile Lys Ala Gln Val Lys Glu
5140 5145 5150
Leu Ser Ser Thr Ala Gln Leu Lys Val Leu Glu Ala Asp Pro Tyr Phe
5155 5160 5165
Thr Val Lys Leu His Asp Lys Thr Ala Val Glu Lys Asp Glu Ile Thr
5170 5175 5180
Leu Lys Cys Glu Val Ser Lys Asp Val Pro Val Lys Trp Phe Lys Asp
5185 5190 5195 5200
Gly Glu Glu Ile Val Pro Ser Pro Lys Tyr Ser Ile Lys Ala Asp Gly
5205 5210 5215
Leu Arg Arg Ile Leu Lys Ile Lys Lys Ala Asp Leu Lys Asp Lys Gly
5220 5225 5230
Glu Tyr Val Cys Asp Cys Gly Thr Asp Lys Thr Lys Ala Asn Val Thr
5235 5240 5245
Val Glu Ala Arg Leu Ile Glu Val Glu Lys Pro Leu Tyr Gly Val Glu
5250 5255 5260
Val Phe Val Gly Glu Thr Ala His Phe Glu Ile Glu Leu Ser Glu Pro
5265 5270 5275 5280
Asp Val His Gly Gln Trp Lys Leu Lys Gly Gln Pro Leu Thr Ala Ser
5285 5290 5295
Pro Asp Cys Glu Ile Ile Glu Asp Gly Lys Lys His Ile Leu Ile Leu
5300 5305 5310
His Asn Cys Gln Leu Gly Met Thr Gly Glu Val Ser Phe Gln Ala Ala
5315 5320 5325
Asn Ala Lys Ser Ala Ala Asn Leu Lys Val Lys Glu Leu Pro Leu Ile
5330 5335 5340
Phe Ile Thr Pro Leu Ser Asp Val Lys Val Phe Glu Lys Asp Glu Ala
5345 5350 5355 5360
Lys Phe Glu Cys Glu Val Ser Arg Glu Pro Lys Thr Phe Arg Trp Leu
5365 5370 5375
Lys Gly Thr Gln Glu Ile Thr Gly Asp Asp Arg Phe Glu Leu Ile Lys
5380 5385 5390
Asp Gly Thr Lys His Ser Met Val Ile Lys Ser Ala Ala Phe Glu Asp
5395 5400 5405
Glu Ala Lys Tyr Met Phe Glu Ala Glu Asp Lys His Thr Ser Gly Lys
5410 5415 5420
Leu Ile Ile Glu Gly Ile Arg Leu Lys Phe Leu Thr Pro Leu Lys Asp
5425 5430 5435 5440
Val Thr Ala Lys Glu Lys Glu Ser Ala Val Phe Thr Val Glu Leu Ser
5445 5450 5455
His Asp Asn Ile Arg Val Lys Trp Phe Lys Asn Asp Gln Arg Leu His
5460 5465 5470
Thr Thr Arg Ser Val Ser Met Gln Asp Glu Gly Lys Thr His Ser Ile
5475 5480 5485
Thr Phe Lys Asp Leu Ser Ile Asp Asp Thr Ser Gln Ile Arg Val Glu
5490 5495 5500
Ala Met Gly Met Ser Ser Glu Ala Lys Leu Thr Val Leu Glu Gly Asp
5505 5510 5515 5520
Pro Tyr Phe Thr Gly Lys Leu Gln Asp Tyr Thr Gly Val Glu Lys Asp
5525 5530 5535
Glu Val Ile Leu Gln Cys Glu Ile Ser Lys Ala Asp Ala Pro Val Lys
5540 5545 5550
Trp Phe Lys Asp Gly Lys Glu Ile Lys Pro Ser Lys Asn Ala Val Ile
5555 5560 5565
Lys Thr Asp Gly Lys Lys Arg Met Leu Ile Leu Lys Lys Ala Leu Lys
5570 5575 5580
Ser Asp Ile Gly Gln Tyr Thr Cys Asp Cys Gly Thr Asp Lys Thr Ser
5585 5590 5595 5600
Gly Lys Leu Asp Ile Glu Asp Arg Glu Ile Lys Leu Val Arg Pro Leu
5605 5610 5615
His Ser Val Glu Val Met Glu Thr Glu Thr Ala Arg Phe Glu Thr Glu
5620 5625 5630
Ile Ser Glu Asp Asp Ile His Ala Asn Trp Lys Leu Lys Gly Glu Ala
5635 5640 5645
Leu Leu Gln Thr Pro Asp Cys Glu Ile Lys Glu Glu Gly Lys Ile His
5650 5655 5660
Ser Leu Val Leu His Asn Cys Arg Leu Asp Gln Thr Gly Gly Val Asp
5665 5670 5675 5680
Phe Gln Ala Ala Asn Val Lys Ser Ser Ala His Leu Arg Val Lys Pro
5685 5690 5695
Arg Val Ile Gly Leu Leu Arg Pro Leu Lys Asp Val Thr Val Thr Ala
5700 5705 5710
Gly Glu Thr Ala Thr Phe Asp Cys Glu Leu Ser Tyr Glu Asp Ile Pro
5715 5720 5725
Val Glu Trp Tyr Leu Lys Gly Lys Lys Leu Glu Pro Ser Asp Lys Val
5730 5735 5740
Val Pro Arg Ser Glu Gly Lys Val His Thr Leu Thr Leu Arg Asp Val
5745 5750 5755 5760
Lys Leu Glu Asp Ala Gly Glu Val Gln Leu Thr Ala Lys Asp Phe Lys
5765 5770 5775
Thr His Ala Asn Leu Phe Val Lys Glu Pro Pro Val Glu Phe Thr Lys
5780 5785 5790
Pro Leu Glu Asp Gln Thr Val Glu Glu Gly Ala Thr Ala Val Leu Glu
5795 5800 5805
Cys Glu Val Ser Arg Glu Asn Ala Lys Val Lys Trp Phe Lys Asn Gly
5810 5815 5820
Thr Glu Ile Leu Lys Ser Lys Lys Tyr Glu Ile Val Ala Asp Gly Arg
5825 5830 5835 5840
Val Arg Lys Leu Val Ile His Asp Cys Thr Pro Glu Asp Ile Lys Thr
5845 5850 5855
Tyr Thr Cys Asp Ala Lys Asp Phe Lys Thr Ser Cys Asn Leu Asn Val
5860 5865 5870
Val Pro Pro His Val Glu Phe Leu Arg Pro Leu Thr Asp Leu Gln Val
5875 5880 5885
Arg Glu Lys Glu Met Ala Arg Phe Glu Cys Glu Leu Ser Arg Glu Asn
5890 5895 5900
Ala Lys Val Lys Trp Phe Lys Asp Gly Ala Glu Ile Lys Lys Gly Lys
5905 5910 5915 5920
Lys Tyr Asp Ile Ile Ser Lys Gly Ala Val Arg Ile Leu Val Ile Asn
5925 5930 5935
Lys Cys Leu Leu Asp Asp Glu Ala Glu Tyr Ser Cys Glu Val Arg Thr
5940 5945 5950
Ala Arg Thr Ser Gly Met Leu Thr Val Leu Glu Glu Glu Ala Val Phe
5955 5960 5965
Thr Lys Asn Leu Ala Asn Ile Glu Val Ser Glu Thr Asp Thr Ile Lys
5970 5975 5980
Leu Val Cys Glu Val Ser Lys Pro Gly Ala Glu Val Ile Trp Tyr Lys
5985 5990 5995 6000
Gly Asp Glu Glu Ile Ile Glu Thr Gly Arg Tyr Glu Ile Leu Thr Glu
6005 6010 6015
Gly Arg Lys Arg Ile Leu Val Ile Gln Asn Ala His Leu Glu Asp Ala
6020 6025 6030
Gly Asn Tyr Asn Cys Arg Leu Pro Ser Ser Arg Thr Asp Gly Lys Val
6035 6040 6045
Lys Val His Glu Leu Ala Ala Glu Phe Ile Ser Lys Pro Gln Asn Leu
6050 6055 6060
Glu Ile Leu Glu Gly Glu Lys Ala Glu Phe Val Cys Ser Ile Ser Lys
6065 6070 6075 6080
Glu Ser Phe Pro Val Gln Trp Lys Arg Asp Asp Lys Thr Leu Glu Ser
6085 6090 6095
Gly Asp Lys Tyr Asp Val Ile Ala Asp Gly Lys Lys Arg Val Leu Val
6100 6105 6110
Val Lys Asp Ala Thr Leu Gln Asp Met Gly Thr Tyr Val Val Met Val
6115 6120 6125
Gly Ala Ala Arg Ala Ala Ala His Leu Thr Val Ile Glu Lys Leu Arg
6130 6135 6140
Ile Val Val Pro Leu Lys Asp Thr Arg Val Lys Glu Gln Gln Glu Val
6145 6150 6155 6160
Val Phe Asn Cys Glu Val Asn Thr Glu Gly Ala Lys Ala Lys Trp Phe
6165 6170 6175
Arg Asn Glu Glu Ala Ile Phe Asp Ser Ser Lys Tyr Ile Ile Leu Gln
6180 6185 6190
Lys Asp Leu Val Tyr Thr Leu Arg Ile Arg Asp Ala His Leu Asp Asp
6195 6200 6205
Gln Ala Asn Tyr Asn Val Ser Leu Thr Asn His Arg Gly Glu Asn Val
6210 6215 6220
Lys Ser Ala Ala Asn Leu Ile Val Glu Glu Glu Asp Leu Arg Ile Val
6225 6230 6235 6240
Glu Pro Leu Lys Asp Ile Glu Thr Met Glu Lys Lys Ser Val Thr Phe
6245 6250 6255
Trp Cys Lys Val Asn Arg Leu Asn Val Thr Leu Lys Trp Thr Lys Asn
6260 6265 6270
Gly Glu Glu Val Pro Phe Asp Asn Arg Val Ser Tyr Arg Val Asp Lys
6275 6280 6285
Tyr Lys His Met Leu Thr Ile Lys Asp Cys Gly Phe Pro Asp Glu Gly
6290 6295 6300
Glu Tyr Ile Val Thr Ala Gly Gln Asp Lys Ser Val Ala Glu Leu Leu
6305 6310 6315 6320
Ile Ile Glu Ala Pro Thr Glu Phe Val Glu His Leu Glu Asp Gln Thr
6325 6330 6335
Val Thr Glu Phe Asp Asp Ala Val Phe Ser Cys Gln Leu Ser Arg Glu
6340 6345 6350
Lys Ala Asn Val Lys Trp Tyr Arg Asn Gly Arg Glu Ile Lys Glu Gly
6355 6360 6365
Lys Lys Tyr Lys Phe Glu Lys Asp Gly Ser Ile His Arg Leu Ile Ile
6370 6375 6380
Lys Asp Cys Arg Leu Asp Asp Glu Cys Glu Tyr Ala Cys Gly Val Glu
6385 6390 6395 6400
Asp Arg Lys Ser Arg Ala Arg Leu Phe Val Glu Glu Ile Pro Val Glu
6405 6410 6415
Ile Ile Arg Pro Pro Gln Asp Ile Leu Glu Ala Pro Gly Ala Asp Val
6420 6425 6430
Val Phe Leu Ala Glu Leu Asn Lys Asp Lys Val Glu Val Gln Trp Leu
6435 6440 6445
Arg Asn Asn Met Val Val Val Gln Gly Asp Lys His Gln Met Met Ser
6450 6455 6460
Glu Gly Lys Ile His Arg Leu Gln Ile Cys Asp Ile Lys Pro Arg Asp
6465 6470 6475 6480
Gln Gly Glu Tyr Arg Phe Ile Ala Lys Asp Lys Glu Ala Arg Ala Lys
6485 6490 6495
Leu Glu Leu Ala Ala Ala Pro Lys Ile Lys Thr Ala Asp Gln Asp Leu
6500 6505 6510
Val Val Asp Val Gly Lys Pro Leu Thr Met Val Val Pro Tyr Asp Ala
6515 6520 6525
Tyr Pro Lys Ala Glu Ala Glu Trp Phe Lys Glu Asn Glu Pro Leu Ser
6530 6535 6540
Thr Lys Thr Ile Asp Thr Thr Ala Glu Gln Thr Ser Phe Arg Ile Leu
6545 6550 6555 6560
Glu Ala Lys Lys Gly Asp Lys Gly Arg Tyr Lys Ile Val Leu Gln Asn
6565 6570 6575
Lys His Gly Lys Ala Glu Gly Phe Ile Asn Leu Lys Val Ile Asp Val
6580 6585 6590
Pro Gly Pro Val Arg Asn Leu Glu Val Thr Glu Thr Phe Asp Gly Glu
6595 6600 6605
Val Ser Leu Ala Trp Glu Glu Pro Leu Thr Asp Gly Gly Ser Lys Ile
6610 6615 6620
Ile Gly Tyr Val Val Glu Arg Arg Asp Ile Lys Arg Lys Thr Trp Val
6625 6630 6635 6640
Leu Ala Thr Asp Arg Ala Glu Ser Cys Glu Phe Thr Val Thr Gly Leu
6645 6650 6655
Gln Lys Gly Gly Val Glu Tyr Leu Phe Arg Val Ser Ala Arg Asn Arg
6660 6665 6670
Val Gly Thr Gly Glu Pro Val Glu Thr Asp Asn Pro Val Glu Ala Arg
6675 6680 6685
Ser Lys Tyr Asp Val Pro Gly Pro Pro Leu Asn Val Thr Ile Thr Asp
6690 6695 6700
Val Asn Arg Phe Gly Val Ser Leu Thr Trp Glu Pro Pro Glu Tyr Asp
6705 6710 6715 6720
Gly Gly Ala Glu Ile Thr Asn Tyr Val Ile Glu Leu Arg Asp Lys Thr
6725 6730 6735
Ser Ile Arg Trp Asp Thr Ala Met Thr Val Arg Ala Glu Asp Leu Ser
6740 6745 6750
Ala Thr Val Thr Asp Val Val Glu Gly Gln Glu Tyr Ser Phe Arg Val
6755 6760 6765
Arg Ala Gln Asn Arg Ile Gly Val Gly Lys Pro Ser Ala Ala Thr Pro
6770 6775 6780
Phe Val Lys Val Ala Asp Pro Ile Glu Arg Pro Ser Pro Pro Val Asn
6785 6790 6795 6800
Leu Thr Ser Ser Asp Gln Thr Gln Ser Ser Val Gln Leu Lys Trp Glu
6805 6810 6815
Pro Pro Leu Lys Asp Gly Gly Ser Pro Ile Leu Gly Tyr Ile Ile Glu
6820 6825 6830
Arg Cys Glu Glu Gly Lys Asp Asn Trp Ile Arg Cys Asn Met Lys Leu
6835 6840 6845
Val Pro Glu Leu Thr Tyr Lys Val Thr Gly Leu Glu Lys Gly Asn Lys
6850 6855 6860
Tyr Leu Tyr Arg Val Ser Ala Glu Asn Lys Ala Gly Val Ser Asp Pro
6865 6870 6875 6880
Ser Glu Ile Leu Gly Pro Leu Thr Ala Asp Asp Ala Phe Val Glu Pro
6885 6890 6895
Thr Met Asp Leu Ser Ala Phe Lys Asp Gly Leu Glu Val Ile Val Pro
6900 6905 6910
Asn Pro Ile Thr Ile Leu Val Pro Ser Thr Gly Tyr Pro Arg Pro Thr
6915 6920 6925
Ala Thr Trp Cys Phe Gly Asp Lys Val Leu Glu Thr Gly Asp Arg Val
6930 6935 6940
Lys Met Lys Thr Leu Ser Ala Tyr Ala Glu Leu Val Ile Ser Pro Ser
6945 6950 6955 6960
Glu Arg Ser Asp Lys Gly Ile Tyr Thr Leu Lys Leu Glu Asn Arg Val
6965 6970 6975
Lys Thr Ile Ser Gly Glu Ile Asp Val Asn Val Ile Ala Arg Pro Ser
6980 6985 6990
Ala Pro Lys Glu Leu Lys Phe Gly Asp Ile Thr Lys Asp Ser Val His
6995 7000 7005
Leu Thr Trp Glu Pro Pro Asp Asp Asp Gly Gly Ser Pro Leu Thr Gly
7010 7015 7020
Tyr Val Val Glu Lys Arg Glu Val Ser Arg Lys Thr Trp Thr Lys Val
7025 7030 7035 7040
Met Asp Phe Val Thr Asp Leu Glu Phe Thr Val Pro Asp Leu Val Gln
7045 7050 7055
Gly Lys Glu Tyr Leu Phe Lys Val Cys Ala Arg Asn Lys Cys Gly Pro
7060 7065 7070
Gly Glu Pro Ala Tyr Val Asp Glu Pro Val Asn Met Ser Thr Pro Ala
7075 7080 7085
Thr Val Pro Asp Pro Pro Glu Asn Val Lys Trp Arg Asp Arg Thr Ala
7090 7095 7100
Asn Ser Ile Phe Leu Thr Trp Asp Pro Pro Lys Asn Asp Gly Gly Ser
7105 7110 7115 7120
Arg Ile Lys Gly Tyr Ile Val Glu Arg Cys Pro Arg Gly Ser Asp Lys
7125 7130 7135
Trp Val Ala Cys Gly Glu Pro Val Ala Glu Thr Lys Met Glu Val Thr
7140 7145 7150
Gly Leu Glu Glu Gly Lys Trp Tyr Ala Tyr Arg Val Lys Thr Leu Asn
7155 7160 7165
Arg Gln Gly Ala Ser Lys Pro Ser Arg Pro Thr Glu Glu Ile Gln Ala
7170 7175 7180
Val Asp Thr Gln Glu Ala Pro Glu Ile Phe Leu Asp Val Lys Leu Leu
7185 7190 7195 7200
Ala Gly Leu Thr Val Lys Ala Gly Thr Lys Ile Glu Leu Pro Ala Thr
7205 7210 7215
Val Thr Gly Lys Pro Glu Pro Lys Ile Thr Trp Thr Lys Ala Asp Met
7220 7225 7230
Ile Leu Lys Gln Asp Lys Arg Ile Thr Ile Glu Asn Val Pro Lys Lys
7235 7240 7245
Ser Thr Val Thr Ile Val Asp Ser Lys Arg Ser Asp Thr Gly Thr Tyr
7250 7255 7260
Ile Ile Glu Ala Val Asn Val Cys Gly Arg Ala Thr Ala Val Val Glu
7265 7270 7275 7280
Val Asn Val Leu Asp Lys Pro Gly Pro Pro Ala Ala Phe Asp Ile Thr
7285 7290 7295
Asp Val Thr Asn Glu Ser Cys Leu Leu Thr Trp Asn Pro Pro Arg Asp
7300 7305 7310
Asp Gly Gly Ser Lys Ile Thr Asn Tyr Val Val Glu Arg Arg Ala Thr
7315 7320 7325
Asp Ser Glu Val Trp His Lys Leu Ser Ser Thr Val Lys Asp Thr Asn
7330 7335 7340
Phe Lys Ala Thr Lys Leu Ile Pro Asn Lys Glu Tyr Ile Phe Arg Val
7345 7350 7355 7360
Ala Ala Glu Asn Met Tyr Gly Ala Gly Glu Pro Val Gln Ala Ser Pro
7365 7370 7375
Ile Thr Ala Lys Tyr Gln Phe Asp Pro Pro Gly Pro Pro Thr Arg Leu
7380 7385 7390
Glu Pro Ser Asp Ile Thr Lys Asp Ala Val Thr Leu Thr Trp Cys Glu
7395 7400 7405
Pro Asp Asp Asp Gly Gly Ser Pro Ile Thr Gly Tyr Trp Val Glu Arg
7410 7415 7420
Leu Asp Pro Asp Thr Asp Lys Trp Val Arg Cys Asn Lys Met Pro Val
7425 7430 7435 7440
Lys Asp Thr Thr Tyr Arg Val Lys Gly Leu Thr Asn Lys Lys Lys Tyr
7445 7450 7455
Arg Phe Arg Val Leu Ala Glu Asn Leu Ala Gly Pro Gly Lys Pro Ser
7460 7465 7470
Lys Ser Thr Glu Pro Ile Leu Ile Lys Asp Pro Ile Asp Pro Pro Trp
7475 7480 7485
Pro Pro Gly Lys Pro Thr Val Lys Asp Val Gly Lys Thr Ser Val Arg
7490 7495 7500
Leu Asn Trp Thr Lys Pro Glu His Asp Gly Gly Ala Lys Ile Glu Ser
7505 7510 7515 7520
Tyr Val Ile Glu Met Leu Lys Thr Gly Thr Asp Glu Trp Val Arg Val
7525 7530 7535
Ala Glu Gly Val Pro Thr Thr Gln His Leu Leu Pro Gly Leu Met Glu
7540 7545 7550
Gly Gln Glu Tyr Ser Phe Arg Val Arg Ala Val Asn Lys Ala Gly Glu
7555 7560 7565
Ser Glu Pro Ser Glu Pro Ser Asp Pro Val Leu Cys Arg Glu Lys Leu
7570 7575 7580
Tyr Pro Pro Ser Pro Pro Arg Trp Leu Glu Val Ile Asn Ile Thr Lys
7585 7590 7595 7600
Asn Thr Ala Asp Leu Lys Trp Thr Val Pro Glu Lys Asp Gly Gly Ser
7605 7610 7615
Pro Ile Thr Asn Tyr Ile Val Glu Lys Arg Asp Val Arg Arg Lys Gly
7620 7625 7630
Trp Gln Thr Val Asp Thr Thr Val Lys Asp Thr Lys Cys Thr Val Thr
7635 7640 7645
Pro Leu Thr Glu Gly Ser Leu Tyr Val Phe Arg Val Ala Ala Glu Asn
7650 7655 7660
Ala Ile Gly Gln Ser Asp Tyr Thr Glu Ile Glu Asp Ser Val Leu Ala
7665 7670 7675 7680
Lys Asp Thr Phe Thr Thr Pro Gly Pro Pro Tyr Ala Leu Ala Val Val
7685 7690 7695
Asp Val Thr Lys Arg His Val Asp Leu Lys Trp Glu Pro Pro Lys Asn
7700 7705 7710
Asp Gly Gly Arg Pro Ile Gln Arg Tyr Val Ile Glu Lys Lys Glu Arg
7715 7720 7725
Leu Gly Thr Arg Trp Val Lys Ala Gly Lys Thr Ala Gly Pro Asp Cys
7730 7735 7740
Asn Phe Arg Val Thr Asp Val Ile Glu Gly Thr Glu Val Gln Phe Gln
7745 7750 7755 7760
Val Arg Ala Glu Asn Glu Ala Gly Val Gly His Pro Ser Glu Pro Thr
7765 7770 7775
Glu Ile Leu Ser Ile Glu Asp Pro Thr Ser Pro Pro Ser Pro Pro Leu
7780 7785 7790
Asp Leu His Val Thr Asp Ala Gly Arg Lys His Ile Ala Ile Ala Trp
7795 7800 7805
Lys Pro Pro Glu Lys Asn Gly Gly Ser Pro Ile Ile Gly Tyr His Val
7810 7815 7820
Glu Met Cys Pro Val Gly Thr Glu Lys Trp Met Arg Val Asn Ser Arg
7825 7830 7835 7840
Pro Ile Lys Asp Leu Lys Phe Lys Val Glu Glu Gly Val Val Pro Asp
7845 7850 7855
Lys Glu Tyr Val Leu Arg Val Arg Ala Val Asn Ala Ile Gly Val Ser
7860 7865 7870
Glu Pro Ser Glu Ile Ser Glu Asn Val Val Ala Lys Asp Pro Asp Cys
7875 7880 7885
Lys Pro Thr Ile Asp Leu Glu Thr His Asp Ile Ile Val Ile Glu Gly
7890 7895 7900
Glu Lys Leu Ser Ile Pro Val Pro Phe Arg Ala Val Pro Val Pro Thr
7905 7910 7915 7920
Val Ser Trp His Lys Asp Gly Lys Glu Val Lys Ala Ser Asp Arg Leu
7925 7930 7935
Thr Met Lys Asn Asp His Ile Ser Ala His Leu Glu Val Pro Lys Ser
7940 7945 7950
Val Arg Ala Asp Ala Gly Ile Tyr Thr Ile Thr Leu Glu Asn Lys Leu
7955 7960 7965
Gly Ser Ala Thr Ala Ser Ile Asn Val Lys Val Ile Gly Leu Pro Gly
7970 7975 7980
Pro Cys Lys Asp Ile Lys Ala Ser Asp Ile Thr Lys Ser Ser Cys Lys
7985 7990 7995 8000
Leu Thr Trp Glu Pro Pro Glu Phe Asp Gly Gly Thr Pro Ile Leu His
8005 8010 8015
Tyr Val Leu Glu Arg Arg Glu Ala Gly Arg Arg Thr Tyr Ile Pro Val
8020 8025 8030
Met Ser Gly Glu Asn Lys Leu Ser Trp Thr Val Lys Asp Leu Ile Pro
8035 8040 8045
Asn Gly Glu Tyr Phe Phe Arg Val Lys Ala Val Asn Lys Val Gly Gly
8050 8055 8060
Gly Glu Tyr Ile Glu Leu Lys Asn Pro Val Ile Ala Gln Asp Pro Lys
8065 8070 8075 8080
Gln Pro Pro Asp Pro Pro Val Asp Val Glu Val His Asn Pro Thr Ala
8085 8090 8095
Glu Ala Met Thr Ile Thr Trp Lys Pro Pro Leu Tyr Asp Gly Gly Ser
8100 8105 8110
Lys Ile Met Gly Tyr Ile Ile Glu Lys Ile Ala Lys Gly Glu Glu Arg
8115 8120 8125
Trp Lys Arg Cys Asn Glu His Leu Val Pro Ile Leu Thr Tyr Thr Ala
8130 8135 8140
Lys Gly Leu Glu Glu Gly Lys Glu Tyr Gln Phe Arg Val Arg Ala Glu
8145 8150 8155 8160
Asn Ala Ala Gly Ile Ser Glu Pro Ser Arg Ala Thr Pro Pro Thr Lys
8165 8170 8175
Ala Val Asp Pro Ile Asp Ala Pro Lys Val Ile Leu Arg Thr Ser Leu
8180 8185 8190
Glu Val Lys Arg Gly Asp Glu Ile Ala Leu Asp Ala Ser Ile Ser Gly
8195 8200 8205
Ser Pro Tyr Pro Thr Ile Thr Trp Ile Lys Asp Glu Asn Val Ile Val
8210 8215 8220
Pro Glu Glu Ile Lys Lys Arg Ala Ala Pro Leu Val Arg Arg Arg Lys
8225 8230 8235 8240
Gly Glu Val Gln Glu Glu Glu Pro Phe Val Leu Pro Leu Thr Gln Arg
8245 8250 8255
Leu Ser Ile Asp Asn Ser Lys Lys Gly Glu Ser Gln Leu Arg Val Arg
8260 8265 8270
Asp Ser Leu Arg Pro Asp His Gly Leu Tyr Met Ile Lys Val Glu Asn
8275 8280 8285
Asp His Gly Ile Ala Lys Ala Pro Cys Thr Val Ser Val Leu Asp Thr
8290 8295 8300
Pro Gly Pro Pro Ile Asn Phe Val Phe Glu Asp Ile Arg Lys Thr Ser
8305 8310 8315 8320
Val Leu Cys Lys Trp Glu Pro Pro Leu Asp Asp Gly Gly Ser Glu Ile
8325 8330 8335
Ile Asn Tyr Thr Leu Glu Lys Lys Asp Lys Thr Lys Pro Asp Ser Glu
8340 8345 8350
Trp Ile Val Val Thr Ser Thr Leu Arg His Cys Lys Tyr Ser Val Thr
8355 8360 8365
Lys Leu Ile Glu Gly Lys Glu Tyr Leu Phe Arg Val Arg Ala Glu Asn
8370 8375 8380
Arg Phe Gly Pro Gly Pro Pro Cys Val Ser Lys Pro Leu Val Ala Lys
8385 8390 8395 8400
Asp Pro Phe Gly Pro Pro Asp Ala Pro Asp Lys Pro Ile Val Glu Asp
8405 8410 8415
Val Thr Ser Asn Ser Met Leu Val Lys Trp Asn Glu Pro Lys Asp Asn
8420 8425 8430
Gly Ser Pro Ile Leu Gly Tyr Trp Leu Glu Lys Arg Glu Val Asn Ser
8435 8440 8445
Thr His Trp Ser Arg Val Asn Lys Ser Leu Leu Asn Ala Leu Lys Ala
8450 8455 8460
Asn Val Asp Gly Leu Leu Glu Gly Leu Thr Tyr Val Phe Arg Val Cys
8465 8470 8475 8480
Ala Glu Asn Ala Ala Gly Pro Gly Lys Phe Ser Pro Pro Ser Asp Pro
8485 8490 8495
Lys Thr Ala His Asp Pro Ile Ser Pro Pro Gly Pro Pro Ile Pro Arg
8500 8505 8510
Val Thr Asp Thr Ser Ser Thr Thr Ile Glu Leu Glu Trp Glu Pro Pro
8515 8520 8525
Ala Phe Asn Gly Gly Gly Glu Ile Val Gly Tyr Phe Val Asp Lys Gln
8530 8535 8540
Leu Val Gly Thr Asn Lys Trp Ser Arg Cys Thr Glu Lys Met Ile Lys
8545 8550 8555 8560
Val Arg Gln Tyr Thr Val Lys Glu Ile Arg Glu Gly Ala Asp Tyr Lys
8565 8570 8575
Leu Arg Val Ser Ala Val Asn Ala Ala Gly Glu Gly Pro Pro Gly Glu
8580 8585 8590
Thr Gln Pro Val Thr Val Ala Glu Pro Gln Glu Pro Pro Ala Val Glu
8595 8600 8605
Leu Asp Val Ser Val Lys Gly Gly Ile Gln Ile Met Ala Gly Lys Thr
8610 8615 8620
Leu Arg Ile Pro Ala Val Val Thr Gly Arg Pro Val Pro Thr Lys Val
8625 8630 8635 8640
Trp Thr Lys Glu Glu Gly Glu Leu Asp Lys Asp Arg Val Val Ile Asp
8645 8650 8655
Asn Val Gly Thr Lys Ser Glu Leu Ile Ile Lys Asp Ala Leu Arg Lys
8660 8665 8670
Asp His Gly Arg Tyr Val Ile Thr Ala Thr Asn Ser Cys Gly Ser Lys
8675 8680 8685
Phe Ala Ala Ala Arg Val Glu Val Phe Asp Val Pro Gly Pro Val Leu
8690 8695 8700
Asp Leu Lys Pro Val Val Thr Asn Arg Lys Met Cys Leu Leu Asn Trp
8705 8710 8715 8720
Ser Asp Pro Glu Asp Asp Gly Gly Ser Glu Ile Thr Gly Phe Ile Ile
8725 8730 8735
Glu Arg Lys Asp Ala Lys Met His Thr Trp Arg Gln Pro Ile Glu Thr
8740 8745 8750
Glu Arg Ser Lys Cys Asp Ile Thr Gly Leu Leu Glu Gly Gln Glu Tyr
8755 8760 8765
Lys Phe Arg Val Ile Ala Lys Asn Lys Phe Gly Cys Gly Pro Pro Val
8770 8775 8780
Glu Ile Gly Pro Ile Leu Ala Val Asp Pro Leu Gly Pro Pro Thr Ser
8785 8790 8795 8800
Pro Glu Arg Leu Thr Tyr Thr Glu Arg Gln Arg Ser Thr Ile Thr Leu
8805 8810 8815
Asp Trp Lys Glu Pro Arg Ser Asn Gly Gly Ser Pro Ile Gln Gly Tyr
8820 8825 8830
Ile Ile Glu Lys Arg Arg His Asp Lys Pro Asp Phe Glu Arg Val Asn
8835 8840 8845
Lys Arg Leu Cys Pro Thr Thr Ser Phe Leu Val Glu Asn Leu Asp Glu
8850 8855 8860
His Gln Met Tyr Glu Phe Arg Val Lys Ala Val Asn Glu Ile Gly Glu
8865 8870 8875 8880
Ser Glu Pro Ser Leu Pro Leu Asn Val Val Ile Gln Asp Asp Glu Val
8885 8890 8895
Pro Pro Thr Ile Lys Leu Arg Leu Ser Val Arg Gly Asp Thr Ile Lys
8900 8905 8910
Val Lys Ala Gly Glu Pro Val His Ile Pro Ala Asp Val Thr Gly Leu
8915 8920 8925
Pro Met Pro Lys Ile Glu Trp Ser Lys Asn Glu Thr Val Ile Glu Lys
8930 8935 8940
Pro Thr Asp Ala Leu Gln Ile Thr Lys Glu Glu Val Ser Arg Ser Glu
8945 8950 8955 8960
Ala Lys Thr Glu Leu Ser Ile Pro Lys Ala Val Arg Glu Asp Lys Gly
8965 8970 8975
Thr Tyr Thr Val Thr Ala Ser Asn Arg Leu Gly Ser Val Phe Arg Asn
8980 8985 8990
Val His Val Glu Val Tyr Asp Arg Pro Ser Pro Pro Arg Asn Leu Ala
8995 9000 9005
Val Thr Asp Ile Lys Ala Glu Ser Cys Tyr Leu Thr Trp Asp Ala Pro
9010 9015 9020
Leu Asp Asn Gly Gly Ser Glu Ile Thr His Tyr Val Ile Asp Lys Arg
9025 9030 9035 9040
Asp Ala Ser Arg Lys Lys Ala Glu Trp Glu Glu Val Thr Asn Thr Ala
9045 9050 9055
Val Glu Lys Arg Tyr Gly Ile Trp Lys Leu Ile Pro Asn Gly Gln Tyr
9060 9065 9070
Glu Phe Arg Val Arg Ala Val Asn Lys Tyr Gly Ile Ser Asp Glu Cys
9075 9080 9085
Lys Ser Asp Lys Val Val Ile Gln Asp Pro Tyr Arg Leu Pro Gly Pro
9090 9095 9100
Pro Gly Lys Pro Lys Val Leu Ala Arg Thr Lys Gly Ser Met Leu Val
9105 9110 9115 9120
Ser Trp Thr Pro Pro Leu Asp Asn Gly Gly Ser Pro Ile Thr Gly Tyr
9125 9130 9135
Trp Leu Glu Lys Arg Glu Glu Gly Ser Pro Tyr Trp Ser Arg Val Ser
9140 9145 9150
Arg Ala Pro Ile Thr Lys Val Gly Leu Lys Gly Val Glu Phe Asn Val
9155 9160 9165
Pro Arg Leu Leu Glu Gly Val Lys Tyr Gln Phe Arg Ala Met Ala Ile
9170 9175 9180
Asn Ala Ala Gly Ile Gly Pro Pro Ser Glu Pro Ser Asp Pro Glu Val
9185 9190 9195 9200
Ala Gly Asp Pro Ile Phe Pro Pro Gly Pro Pro Ser Cys Pro Glu Val
9205 9210 9215
Lys Asp Lys Thr Lys Ser Ser Ile Ser Leu Gly Trp Lys Pro Pro Ala
9220 9225 9230
Lys Asp Gly Gly Ser Pro Ile Lys Gly Tyr Ile Val Glu Met Gln Glu
9235 9240 9245
Glu Gly Thr Thr Asp Trp Lys Arg Val Asn Glu Pro Asp Lys Leu Ile
9250 9255 9260
Thr Thr Cys Glu Cys Val Val Pro Asn Leu Lys Glu Leu Arg Lys Tyr
9265 9270 9275 9280
Arg Phe Arg Val Lys Ala Val Asn Glu Ala Gly Glu Ser Glu Pro Ser
9285 9290 9295
Asp Thr Thr Gly Glu Ile Pro Ala Thr Asp Ile Gln Glu Glu Pro Glu
9300 9305 9310
Val Phe Ile Asp Ile Gly Ala Gln Asp Cys Leu Val Cys Lys Ala Gly
9315 9320 9325
Ser Gln Ile Arg Ile Pro Ala Val Ile Lys Gly Arg Pro Thr Pro Lys
9330 9335 9340
Ser Ser Trp Glu Phe Asp Gly Lys Ala Lys Lys Ala Met Lys Asp Gly
9345 9350 9355 9360
Val His Asp Ile Pro Glu Asp Ala Gln Leu Glu Thr Ala Glu Asn Ser
9365 9370 9375
Ser Val Ile Ile Ile Pro Glu Cys Lys Arg Ser His Thr Gly Lys Tyr
9380 9385 9390
Ser Ile Thr Ala Lys Asn Lys Ala Gly Gln Lys Thr Ala Asn Cys Arg
9395 9400 9405
Val Lys Val Met Asp Val Pro Gly Pro Pro Lys Asp Leu Lys Val Ser
9410 9415 9420
Asp Ile Thr Arg Gly Ser Cys Arg Leu Ser Trp Lys Met Pro Asp Asp
9425 9430 9435 9440
Asp Gly Gly Asp Arg Ile Lys Gly Tyr Val Ile Glu Lys Arg Thr Ile
9445 9450 9455
Asp Gly Lys Ala Trp Thr Lys Val Asn Pro Asp Cys Gly Ser Thr Thr
9460 9465 9470
Phe Val Val Pro Asp Leu Leu Ser Glu Gln Gln Tyr Phe Phe Arg Val
9475 9480 9485
Arg Ala Glu Asn Arg Phe Gly Ile Gly Pro Pro Val Glu Thr Ile Gln
9490 9495 9500
Arg Thr Thr Ala Arg Asp Pro Ile Tyr Pro Pro Asp Pro Pro Ile Lys
9505 9510 9515 9520
Leu Lys Ile Gly Leu Ile Thr Lys Asn Thr Val His Leu Ser Trp Lys
9525 9530 9535
Pro Pro Lys Asn Asp Gly Gly Ser Pro Val Thr His Tyr Ile Val Glu
9540 9545 9550
Cys Leu Ala Trp Asp Pro Thr Gly Thr Lys Lys Glu Ala Trp Arg Gln
9555 9560 9565
Cys Asn Lys Arg Asp Val Glu Glu Leu Gln Phe Thr Val Glu Asp Leu
9570 9575 9580
Val Glu Gly Gly Glu Tyr Glu Phe Arg Val Lys Ala Val Asn Ala Ala
9585 9590 9595 9600
Gly Val Ser Lys Pro Ser Ala Thr Val Gly Pro Cys Asp Cys Gln Arg
9605 9610 9615
Pro Asp Met Pro Pro Ser Ile Asp Leu Lys Glu Phe Met Glu Val Glu
9620 9625 9630
Glu Gly Thr Asn Val Asn Ile Val Ala Lys Ile Lys Gly Val Pro Phe
9635 9640 9645
Pro Thr Leu Thr Trp Phe Lys Ala Pro Pro Lys Lys Pro Asp Asn Lys
9650 9655 9660
Glu Pro Val Leu Tyr Asp Thr His Val Asn Lys Leu Val Val Asp Asp
9665 9670 9675 9680
Thr Cys Thr Leu Val Ile Pro Gln Ser Arg Arg Ser Asp Thr Gly Leu
9685 9690 9695
Tyr Thr Ile Thr Ala Val Asn Asn Leu Gly Thr Ala Ser Lys Glu Met
9700 9705 9710
Arg Leu Asn Val Leu Gly Arg Pro Gly Pro Pro Val Gly Pro Ile Lys
9715 9720 9725
Phe Glu Ser Val Ser Ala Asp Gln Met Thr Leu Ser Trp Phe Pro Pro
9730 9735 9740
Lys Asp Asp Gly Gly Ser Lys Ile Thr Asn Tyr Val Ile Glu Lys Arg
9745 9750 9755 9760
Glu Ala Asn Arg Lys Thr Trp Val His Val Ser Ser Glu Pro Lys Glu
9765 9770 9775
Cys Thr Tyr Thr Ile Pro Lys Leu Leu Glu Gly His Glu Tyr Val Phe
9780 9785 9790
Arg Ile Met Ala Gln Asn Lys Tyr Gly Ile Gly Glu Pro Leu Asp Ser
9795 9800 9805
Glu Pro Glu Thr Ala Arg Asn Leu Phe Ser Val Pro Gly Ala Pro Asp
9810 9815 9820
Lys Pro Thr Val Ser Ser Val Thr Arg Asn Ser Met Thr Val Asn Trp
9825 9830 9835 9840
Glu Glu Pro Glu Tyr Asp Gly Gly Ser Pro Val Thr Gly Tyr Trp Leu
9845 9850 9855
Glu Met Lys Asp Thr Thr Ser Lys Arg Trp Lys Arg Val Asn Arg Asp
9860 9865 9870
Pro Ile Lys Ala Met Thr Leu Gly Val Ser Tyr Lys Val Thr Gly Leu
9875 9880 9885
Ile Glu Gly Ser Asp Tyr Gln Phe Arg Val Tyr Ala Ile Asn Ala Ala
9890 9895 9900
Gly Val Gly Pro Ala Ser Leu Pro Ser Asp Pro Ala Thr Ala Arg Asp
9905 9910 9915 9920
Pro Ile Ala Pro Pro Gly Pro Pro Phe Pro Lys Val Thr Asp Trp Thr
9925 9930 9935
Lys Ser Ser Ala Asp Leu Glu Trp Ser Pro Pro Leu Lys Asp Gly Gly
9940 9945 9950
Ser Lys Val Thr Gly Tyr Ile Val Glu Tyr Lys Glu Glu Gly Lys Glu
9955 9960 9965
Glu Trp Glu Lys Gly Lys Asp Lys Glu Val Arg Gly Thr Lys Leu Val
9970 9975 9980
Val Thr Gly Leu Lys Glu Gly Ala Phe Tyr Lys Phe Arg Val Ser Ala
9985 9990 9995 10000
Val Asn Ile Ala Gly Ile Gly Glu Pro Gly Glu Val Thr Asp Val Ile
10005 10010 10015
Glu Met Lys Asp Arg Leu Val Ser Pro Asp Leu Gln Leu Asp Ala Ser
10020 10025 10030
Val Arg Asp Arg Ile Val Val His Ala Gly Gly Val Ile Arg Ile Ile
10035 10040 10045
Ala Tyr Val Ser Gly Lys Pro Pro Pro Thr Val Thr Trp Asn Met Asn
10050 10055 10060
Glu Arg Thr Leu Pro Gln Glu Ala Thr Ile Glu Thr Thr Ala Ile Ser
10065 10070 10075 10080
Ser Ser Met Val Ile Lys Asn Cys Gln Arg Ser His Gln Gly Val Tyr
10085 10090 10095
Ser Leu Leu Ala Lys Asn Glu Ala Gly Glu Arg Lys Lys Thr Ile Ile
10100 10105 10110
Val Asp Val Leu Asp Val Pro Gly Pro Val Gly Thr Pro Phe Leu Ala
10115 10120 10125
His Asn Leu Thr Asn Glu Ser Cys Lys Leu Thr Trp Phe Ser Pro Glu
10130 10135 10140
Asp Asp Gly Gly Ser Pro Ile Thr Asn Tyr Val Ile Glu Lys Arg Glu
10145 10150 10155 10160
Ser Asp Arg Arg Ala Trp Thr Pro Val Thr Tyr Thr Val Thr Arg Gln
10165 10170 10175
Asn Ala Thr Val Gln Gly Leu Ile Gln Gly Lys Ala Tyr Phe Phe Arg
10180 10185 10190
Ile Ala Ala Glu Asn Ser Ile Gly Met Gly Pro Phe Val Glu Thr Ser
10195 10200 10205
Glu Ala Leu Val Ile Arg Glu Pro Ile Thr Val Pro Glu Arg Pro Glu
10210 10215 10220
Asp Leu Glu Val Lys Glu Val Thr Lys Asn Thr Val Thr Leu Thr Trp
10225 10230 10235 10240
Asn Pro Pro Lys Tyr Asp Gly Gly Ser Glu Ile Ile Asn Tyr Val Leu
10245 10250 10255
Glu Ser Arg Leu Ile Gly Thr Glu Lys Phe His Lys Val Thr Asn Asp
10260 10265 10270
Asn Leu Leu Ser Arg Lys Tyr Thr Val Lys Gly Leu Lys Glu Gly Asp
10275 10280 10285
Thr Tyr Glu Tyr Arg Val Ser Ala Val Asn Ile Val Gly Gln Gly Lys
10290 10295 10300
Pro Ser Phe Cys Thr Lys Pro Ile Thr Cys Lys Asp Glu Leu Ala Pro
10305 10310 10315 10320
Pro Thr Leu His Leu Asp Phe Arg Asp Lys Leu Thr Ile Arg Val Gly
10325 10330 10335
Glu Ala Phe Ala Leu Thr Gly Arg Tyr Ser Gly Lys Pro Lys Pro Lys
10340 10345 10350
Val Ser Trp Phe Lys Asp Glu Ala Asp Val Leu Glu Asp Asp Arg Thr
10355 10360 10365
His Ile Lys Thr Thr Pro Ala Thr Leu Ala Leu Glu Lys Ile Lys Ala
10370 10375 10380
Lys Arg Ser Asp Ser Gly Lys Tyr Cys Val Val Val Glu Asn Ser Thr
10385 10390 10395 10400
Gly Ser Arg Lys Gly Phe Cys Gln Val Asn Val Val Asp His Pro Gly
10405 10410 10415
Pro Pro Val Gly Pro Val Ser Phe Asp Glu Val Thr Lys Asp Tyr Met
10420 10425 10430
Val Ile Ser Trp Lys Pro Pro Leu Asp Asp Gly Gly Ser Lys Ile Thr
10435 10440 10445
Asn Tyr Ile Ile Glu Lys Lys Glu Val Gly Lys Asp Val Trp Met Pro
10450 10455 10460
Val Thr Ser Ala Ser Ala Lys Thr Thr Cys Lys Val Ser Lys Leu Leu
10465 10470 10475 10480
Glu Gly Lys Asp Tyr Ile Phe Arg Ile His Ala Glu Asn Leu Tyr Gly
10485 10490 10495
Ile Ser Asp Pro Leu Val Ser Asp Ser Met Lys Ala Lys Asp Arg Phe
10500 10505 10510
Arg Val Pro Asp Ala Pro Asp Gln Pro Ile Val Thr Glu Val Thr Lys
10515 10520 10525
Asp Ser Ala Leu Val Thr Trp Asn Lys Pro His Asp Gly Gly Lys Pro
10530 10535 10540
Ile Thr Asn Tyr Ile Leu Glu Lys Arg Glu Thr Met Ser Lys Arg Trp
10545 10550 10555 10560
Ala Arg Val Thr Lys Asp Pro Ile His Pro Tyr Thr Lys Phe Arg Val
10565 10570 10575
Pro Asp Leu Leu Glu Gly Cys Gln Tyr Glu Phe Arg Val Ser Ala Glu
10580 10585 10590
Asn Glu Ile Gly Ile Gly Asp Pro Ser Pro Pro Ser Lys Pro Val Phe
10595 10600 10605
Ala Lys Asp Pro Ile Ala Lys Pro Ser Pro Pro Val Asn Pro Glu Ala
10610 10615 10620
Ile Asp Thr Thr Cys Asn Ser Val Asp Leu Thr Trp Gln Pro Pro Arg
10625 10630 10635 10640
His Asp Gly Gly Ser Lys Ile Leu Gly Tyr Ile Val Glu Tyr Gln Lys
10645 10650 10655
Val Gly Asp Glu Glu Trp Arg Arg Ala Asn His Thr Pro Glu Ser Cys
10660 10665 10670
Pro Glu Thr Lys Tyr Lys Val Thr Gly Leu Arg Asp Gly Gln Thr Tyr
10675 10680 10685
Lys Phe Arg Val Leu Ala Val Asn Ala Ala Gly Glu Ser Asp Pro Ala
10690 10695 10700
His Val Pro Glu Pro Val Leu Val Lys Asp Arg Leu Glu Pro Pro Glu
10705 10710 10715 10720
Leu Ile Leu Asp Ala Asn Met Ala Arg Glu Gln His Ile Lys Val Gly
10725 10730 10735
Asp Thr Leu Arg Leu Ser Ala Ile Ile Lys Gly Val Pro Phe Pro Lys
10740 10745 10750
Val Thr Trp Lys Lys Glu Asp Arg Asp Ala Pro Thr Lys Ala Arg Ile
10755 10760 10765
Asp Val Thr Pro Val Gly Ser Lys Leu Glu Ile Arg Asn Ala Ala His
10770 10775 10780
Glu Asp Gly Gly Ile Tyr Ser Leu Thr Val Glu Asn Pro Ala Gly Ser
10785 10790 10795 10800
Lys Thr Val Ser Val Lys Val Leu Val Leu Asp Lys Pro Gly Pro Pro
10805 10810 10815
Arg Asp Leu Glu Val Ser Glu Ile Arg Lys Asp Ser Cys Tyr Leu Thr
10820 10825 10830
Trp Lys Glu Pro Leu Asp Asp Gly Gly Ser Val Ile Thr Asn Tyr Val
10835 10840 10845
Val Glu Arg Arg Asp Val Ala Ser Ala Gln Trp Ser Pro Leu Ser Ala
10850 10855 10860
Thr Ser Lys Lys Lys Ser His Phe Ala Lys His Leu Asn Glu Gly Asn
10865 10870 10875 10880
Gln Tyr Leu Phe Arg Val Ala Ala Glu Asn Gln Tyr Gly Arg Gly Pro
10885 10890 10895
Phe Val Glu Thr Pro Lys Pro Ile Lys Ala Leu Asp Pro Leu His Pro
10900 10905 10910
Pro Gly Pro Pro Lys Asp Leu His His Val Asp Val Asp Lys Thr Glu
10915 10920 10925
Val Ser Leu Val Trp Asn Lys Pro Asp Arg Asp Gly Gly Ser Pro Ile
10930 10935 10940
Thr Gly Tyr Leu Val Glu Tyr Gln Glu Glu Gly Thr Gln Asp Trp Ile
10945 10950 10955 10960
Lys Phe Lys Thr Val Thr Asn Leu Glu Cys Val Val Thr Gly Leu Gln
10965 10970 10975
Gln Gly Lys Thr Tyr Arg Phe Arg Val Lys Ala Glu Asn Ile Val Gly
10980 10985 10990
Leu Gly Leu Pro Asp Thr Thr Ile Pro Ile Glu Cys Gln Glu Lys Leu
10995 11000 11005
Val Pro Pro Ser Val Glu Leu Asp Val Lys Leu Ile Glu Gly Leu Val
11010 11015 11020
Val Lys Ala Gly Thr Thr Val Arg Phe Pro Ala Ile Ile Arg Gly Val
11025 11030 11035 11040
Pro Val Pro Thr Ala Lys Trp Thr Thr Asp Gly Ser Glu Ile Lys Thr
11045 11050 11055
Asp Glu His Tyr Thr Val Glu Thr Asp Asn Phe Ser Ser Val Leu Thr
11060 11065 11070
Ile Lys Asn Cys Leu Arg Arg Asp Thr Gly Glu Tyr Gln Ile Thr Val
11075 11080 11085
Ser Asn Ala Ala Gly Ser Lys Thr Val Ala Val His Leu Thr Val Leu
11090 11095 11100
Asp Val Pro Gly Pro Pro Thr Gly Pro Ile Asn Ile Leu Asp Val Thr
11105 11110 11115 11120
Pro Glu His Met Thr Ile Ser Trp Gln Pro Pro Lys Asp Asp Gly Gly
11125 11130 11135
Ser Pro Val Ile Asn Tyr Ile Val Glu Lys Gln Asp Thr Arg Lys Asp
11140 11145 11150
Thr Trp Gly Val Val Ser Ser Gly Ser Ser Lys Thr Lys Leu Lys Ile
11155 11160 11165
Pro His Leu Gln Lys Gly Cys Glu Tyr Val Phe Arg Val Arg Ala Glu
11170 11175 11180
Asn Lys Ile Gly Val Gly Pro Pro Leu Asp Ser Thr Pro Thr Val Ala
11185 11190 11195 11200
Lys His Lys Phe Ser Pro Pro Ser Pro Pro Gly Lys Pro Val Val Thr
11205 11210 11215
Asp Ile Thr Glu Asn Ala Ala Thr Val Ser Trp Thr Leu Pro Lys Ser
11220 11225 11230
Asp Gly Gly Ser Pro Ile Thr Gly Tyr Tyr Met Glu Arg Arg Glu Val
11235 11240 11245
Thr Gly Lys Trp Val Arg Val Asn Lys Thr Pro Ile Ala Asp Leu Lys
11250 11255 11260
Phe Arg Val Thr Gly Leu Tyr Glu Gly Asn Thr Tyr Glu Phe Arg Val
11265 11270 11275 11280
Phe Ala Glu Asn Leu Ala Gly Leu Ser Lys Pro Ser Pro Ser Ser Asp
11285 11290 11295
Pro Ile Lys Ala Cys Arg Pro Ile Lys Pro Pro Gly Pro Pro Ile Asn
11300 11305 11310
Pro Lys Leu Lys Asp Lys Ser Arg Glu Thr Ala Asp Leu Val Trp Thr
11315 11320 11325
Lys Pro Leu Ser Asp Gly Gly Ser Pro Ile Leu Gly Tyr Val Val Glu
11330 11335 11340
Cys Gln Lys Pro Gly Thr Ala Gln Trp Asn Arg Ile Asn Lys Asp Glu
11345 11350 11355 11360
Leu Ile Arg Gln Cys Ala Phe Arg Val Pro Gly Leu Ile Glu Gly Asn
11365 11370 11375
Glu Tyr Arg Phe Arg Ile Lys Ala Ala Asn Ile Val Gly Glu Gly Glu
11380 11385 11390
Pro Arg Glu Leu Ala Glu Ser Val Ile Ala Lys Asp Ile Leu His Pro
11395 11400 11405
Pro Glu Val Glu Leu Asp Val Thr Cys Arg Asp Val Ile Thr Val Arg
11410 11415 11420
Val Gly Gln Thr Ile Arg Ile Leu Ala Arg Val Lys Gly Arg Pro Glu
11425 11430 11435 11440
Pro Asp Ile Thr Trp Thr Lys Glu Gly Lys Val Leu Val Arg Glu Lys
11445 11450 11455
Arg Val Asp Leu Ile Gln Asp Leu Pro Arg Val Glu Leu Gln Ile Lys
11460 11465 11470
Glu Ala Val Arg Ala Asp His Gly Lys Tyr Ile Ile Ser Ala Lys Asn
11475 11480 11485
Ser Ser Gly His Ala Gln Gly Ser Ala Ile Val Asn Val Leu Asp Arg
11490 11495 11500
Pro Gly Pro Cys Gln Asn Leu Lys Val Thr Asn Val Thr Lys Glu Asn
11505 11510 11515 11520
Cys Thr Ile Ser Trp Glu Asn Pro Leu Asp Asn Gly Gly Ser Glu Ile
11525 11530 11535
Thr Asn Phe Ile Val Glu Tyr Arg Lys Pro Asn Gln Lys Gly Trp Ser
11540 11545 11550
Ile Val Ala Ser Asp Val Thr Lys Arg Leu Ile Lys Ala Asn Leu Leu
11555 11560 11565
Ala Asn Asn Glu Tyr Tyr Phe Arg Val Cys Ala Glu Asn Lys Val Gly
11570 11575 11580
Val Gly Pro Thr Ile Glu Thr Lys Thr Pro Ile Leu Ala Ile Asn Pro
11585 11590 11595 11600
Ile Asp Arg Pro Gly Glu Pro Glu Asn Leu His Ile Ala Asp Lys Gly
11605 11610 11615
Lys Thr Phe Val Tyr Leu Lys Trp Arg Arg Pro Asp Tyr Asp Gly Gly
11620 11625 11630
Ser Pro Asn Leu Ser Tyr His Val Glu Arg Arg Leu Lys Gly Ser Asp
11635 11640 11645
Asp Trp Glu Arg Val His Lys Gly Ser Ile Lys Glu Thr His Tyr Met
11650 11655 11660
Val Asp Arg Cys Val Glu Asn Gln Ile Tyr Glu Phe Arg Val Gln Thr
11665 11670 11675 11680
Lys Asn Glu Gly Gly Glu Ser Asp Trp Val Lys Thr Glu Glu Val Val
11685 11690 11695
Val Lys Glu Asp Leu Gln Lys Pro Val Leu Asp Leu Lys Leu Ser Gly
11700 11705 11710
Val Leu Thr Val Lys Ala Gly Asp Thr Ile Arg Leu Glu Ala Gly Val
11715 11720 11725
Arg Gly Lys Pro Phe Pro Glu Val Ala Trp Thr Lys Asp Lys Asp Ala
11730 11735 11740
Thr Asp Leu Thr Arg Ser Pro Arg Val Lys Ile Asp Thr Arg Ala Asp
11745 11750 11755 11760
Ser Ser Lys Phe Ser Leu Thr Lys Ala Lys Arg Ser Asp Gly Gly Lys
11765 11770 11775
Tyr Val Val Thr Ala Thr Asn Thr Ala Gly Ser Phe Val Ala Tyr Ala
11780 11785 11790
Thr Val Asn Val Leu Asp Lys Pro Gly Pro Val Arg Asn Leu Lys Ile
11795 11800 11805
Val Asp Val Ser Ser Asp Arg Cys Thr Val Cys Trp Asp Pro Pro Glu
11810 11815 11820
Asp Asp Gly Gly Cys Glu Ile Gln Asn Tyr Ile Leu Glu Lys Cys Glu
11825 11830 11835 11840
Thr Lys Arg Met Val Trp Ser Thr Tyr Ser Ala Thr Val Leu Thr Pro
11845 11850 11855
Gly Thr Thr Val Thr Arg Leu Ile Glu Gly Asn Glu Tyr Ile Phe Arg
11860 11865 11870
Val Arg Ala Glu Asn Lys Ile Gly Thr Gly Pro Pro Thr Glu Ser Lys
11875 11880 11885
Pro Val Ile Ala Lys Thr Lys Tyr Asp Lys Pro Gly Arg Pro Asp Pro
11890 11895 11900
Pro Glu Val Thr Lys Val Ser Lys Glu Glu Met Thr Val Val Trp Asn
11905 11910 11915 11920
Pro Pro Glu Tyr Asp Gly Gly Lys Ser Ile Thr Gly Tyr Phe Leu Glu
11925 11930 11935
Lys Lys Glu Lys His Ser Thr Arg Trp Val Pro Val Asn Lys Ser Ala
11940 11945 11950
Ile Pro Glu Arg Arg Met Lys Val Gln Asn Leu Leu Pro Asp His Glu
11955 11960 11965
Tyr Gln Phe Arg Val Lys Ala Glu Asn Glu Ile Gly Ile Gly Glu Pro
11970 11975 11980
Ser Leu Pro Ser Arg Pro Val Val Ala Lys Asp Pro Ile Glu Pro Pro
11985 11990 11995 12000
Gly Pro Pro Thr Asn Phe Arg Val Val Asp Thr Thr Lys His Ser Ile
12005 12010 12015
Thr Leu Gly Trp Gly Lys Pro Val Tyr Asp Gly Gly Ala Pro Ile Ile
12020 12025 12030
Gly Tyr Val Val Glu Met Arg Pro Lys Ile Ala Asp Ala Ser Pro Asp
12035 12040 12045
Glu Gly Trp Lys Arg Cys Asn Ala Ala Ala Gln Leu Val Arg Lys Glu
12050 12055 12060
Phe Thr Val Thr Ser Leu Asp Glu Asn Gln Glu Tyr Glu Phe Arg Val
12065 12070 12075 12080
Cys Ala Gln Asn Gln Val Gly Ile Gly Arg Pro Ala Glu Leu Lys Glu
12085 12090 12095
Ala Ile Lys Pro Lys Glu Ile Leu Glu Pro Pro Glu Ile Asp Leu Asp
12100 12105 12110
Ala Ser Met Arg Lys Leu Val Ile Val Arg Ala Gly Cys Pro Ile Arg
12115 12120 12125
Leu Phe Ala Ile Val Arg Gly Arg Pro Ala Pro Lys Val Thr Trp Arg
12130 12135 12140
Lys Val Gly Ile Asp Asn Val Val Arg Lys Gly Gln Val Asp Leu Val
12145 12150 12155 12160
Asp Thr Met Ala Phe Leu Val Ile Pro Asn Ser Thr Arg Asp Asp Ser
12165 12170 12175
Gly Lys Tyr Ser Leu Thr Leu Val Asn Pro Ala Gly Glu Lys Ala Val
12180 12185 12190
Phe Val Asn Val Arg Val Leu Asp Thr Pro Gly Pro Val Ser Asp Leu
12195 12200 12205
Lys Val Ser Asp Val Thr Lys Thr Ser Cys His Val Ser Trp Ala Pro
12210 12215 12220
Pro Glu Asn Asp Gly Gly Ser Gln Val Thr His Tyr Ile Val Glu Lys
12225 12230 12235 12240
Arg Glu Ala Asp Arg Lys Thr Trp Ser Thr Val Thr Pro Glu Val Lys
12245 12250 12255
Lys Thr Ser Phe His Val Thr Asn Leu Val Pro Gly Asn Glu Tyr Tyr
12260 12265 12270
Phe Arg Val Thr Ala Val Asn Glu Tyr Gly Pro Gly Val Pro Thr Asp
12275 12280 12285
Val Pro Lys Pro Val Leu Ala Ser Asp Pro Leu Ser Glu Pro Asp Pro
12290 12295 12300
Pro Arg Lys Leu Glu Ala Thr Glu Met Thr Lys Asn Ser Ala Thr Leu
12305 12310 12315 12320
Ala Trp Leu Pro Pro Leu Arg Asp Gly Gly Ala Lys Ile Asp Gly Tyr
12325 12330 12335
Ile Ile Ser Tyr Arg Glu Glu Glu Gln Pro Ala Asp Arg Trp Thr Glu
12340 12345 12350
Tyr Ser Val Val Lys Asp Leu Ser Leu Val Val Thr Gly Leu Lys Glu
12355 12360 12365
Gly Lys Lys Tyr Lys Phe Arg Val Ala Ala Arg Asn Ala Val Gly Val
12370 12375 12380
Ser Leu Pro Arg Glu Ala Glu Gly Val Tyr Glu Ala Lys Glu Gln Leu
12385 12390 12395 12400
Leu Pro Pro Lys Ile Leu Met Pro Glu Gln Ile Thr Ile Lys Ala Gly
12405 12410 12415
Lys Lys Leu Arg Ile Glu Ala His Val Tyr Gly Lys Pro His Pro Thr
12420 12425 12430
Cys Lys Trp Lys Lys Gly Glu Asp Glu Val Val Thr Ser Ser His Leu
12435 12440 12445
Ala Val His Lys Ala Asp Ser Ser Ser Ile Leu Ile Ile Lys Asp Val
12450 12455 12460
Thr Arg Lys Asp Ser Gly Tyr Tyr Ser Leu Thr Ala Glu Asn Ser Ser
12465 12470 12475 12480
Gly Thr Asp Thr Gln Lys Ile Lys Val Val Val Met Asp Ala Pro Gly
12485 12490 12495
Pro Pro Gln Pro Pro Phe Asp Ile Ser Asp Ile Asp Ala Asp Ala Cys
12500 12505 12510
Ser Leu Ser Trp His Ile Pro Leu Glu Asp Gly Gly Ser Asn Ile Thr
12515 12520 12525
Asn Tyr Ile Val Glu Lys Cys Asp Val Ser Arg Gly Asp Trp Val Thr
12530 12535 12540
Ala Leu Ala Ser Val Thr Lys Thr Ser Cys Arg Val Gly Lys Leu Ile
12545 12550 12555 12560
Pro Gly Gln Glu Tyr Ile Phe Arg Val Arg Ala Glu Asn Arg Phe Gly
12565 12570 12575
Ile Ser Glu Pro Leu Thr Ser Pro Lys Met Val Ala Gln Phe Pro Phe
12580 12585 12590
Gly Val Pro Ser Glu Pro Lys Asn Ala Arg Val Thr Lys Val Asn Lys
12595 12600 12605
Asp Cys Ile Phe Val Ala Trp Asp Arg Pro Asp Ser Asp Gly Gly Ser
12610 12615 12620
Pro Ile Ile Gly Tyr Leu Ile Glu Arg Lys Glu Arg Asn Ser Leu Leu
12625 12630 12635 12640
Trp Val Lys Ala Asn Asp Thr Leu Val Arg Ser Thr Glu Tyr Pro Cys
12645 12650 12655
Ala Gly Leu Val Glu Gly Leu Glu Tyr Ser Phe Arg Ile Tyr Ala Leu
12660 12665 12670
Asn Lys Ala Gly Ser Ser Pro Pro Ser Lys Pro Thr Glu Tyr Val Thr
12675 12680 12685
Ala Arg Met Pro Val Asp Pro Pro Gly Lys Pro Glu Val Ile Asp Val
12690 12695 12700
Thr Lys Ser Thr Val Ser Leu Ile Trp Ala Arg Pro Lys His Asp Gly
12705 12710 12715 12720
Gly Ser Lys Ile Ile Gly Tyr Phe Val Glu Ala Cys Lys Leu Pro Gly
12725 12730 12735
Asp Lys Trp Val Arg Cys Asn Thr Ala Pro His Gln Ile Pro Gln Glu
12740 12745 12750
Glu Tyr Thr Ala Thr Gly Leu Glu Glu Lys Ala Gln Tyr Gln Phe Arg
12755 12760 12765
Ala Ile Ala Arg Thr Ala Val Asn Ile Ser Pro Pro Ser Glu Pro Ser
12770 12775 12780
Asp Pro Val Thr Ile Leu Ala Glu Asn Val Pro Pro Arg Ile Asp Leu
12785 12790 12795 12800
Ser Val Ala Met Lys Ser Leu Leu Thr Val Lys Ala Gly Thr Asn Val
12805 12810 12815
Cys Leu Asp Ala Thr Val Phe Gly Lys Pro Met Pro Thr Val Ser Trp
12820 12825 12830
Lys Lys Asp Gly Thr Leu Leu Lys Pro Ala Glu Gly Ile Lys Met Ala
12835 12840 12845
Met Gln Arg Asn Leu Cys Thr Leu Glu Leu Phe Ser Val Asn Arg Lys
12850 12855 12860
Asp Ser Gly Asp Tyr Thr Ile Thr Ala Glu Asn Ser Ser Gly Ser Lys
12865 12870 12875 12880
Ser Ala Thr Ile Lys Leu Lys Val Leu Asp Lys Pro Gly Pro Pro Ala
12885 12890 12895
Ser Val Lys Ile Asn Lys Met Tyr Ser Asp Arg Ala Met Leu Ser Trp
12900 12905 12910
Glu Pro Pro Leu Glu Asp Gly Gly Ser Glu Ile Thr Asn Tyr Ile Val
12915 12920 12925
Asp Lys Arg Glu Thr Ser Arg Pro Asn Trp Ala Gln Val Ser Ala Thr
12930 12935 12940
Val Pro Ile Thr Ser Cys Ser Val Glu Lys Leu Ile Glu Gly His Glu
12945 12950 12955 12960
Tyr Gln Phe Arg Ile Cys Ala Glu Asn Lys Tyr Gly Val Gly Asp Pro
12965 12970 12975
Val Phe Thr Glu Pro Ala Ile Ala Lys Asn Pro Tyr Asp Pro Pro Gly
12980 12985 12990
Arg Cys Asp Pro Pro Val Ile Ser Asn Ile Thr Lys Asp His Met Thr
12995 13000 13005
Val Ser Trp Lys Pro Pro Ala Asp Asp Gly Gly Ser Pro Ile Thr Gly
13010 13015 13020
Tyr Leu Leu Glu Lys Arg Glu Thr Gln Ala Val Asn Trp Thr Lys Val
13025 13030 13035 13040
Asn Arg Lys Pro Ile Ile Glu Arg Thr Leu Lys Ala Thr Gly Leu Gln
13045 13050 13055
Glu Gly Thr Glu Tyr Glu Phe Arg Val Thr Ala Ile Asn Lys Ala Gly
13060 13065 13070
Pro Gly Lys Pro Ser Asp Ala Ser Lys Ala Ala Tyr Ala Arg Asp Pro
13075 13080 13085
Gln Tyr Pro Pro Ala Pro Pro Ala Phe Pro Lys Val Tyr Asp Thr Thr
13090 13095 13100
Arg Ser Ser Val Ser Leu Ser Trp Gly Lys Pro Ala Tyr Asp Gly Gly
13105 13110 13115 13120
Ser Pro Ile Ile Gly Tyr Leu Val Glu Val Lys Arg Ala Asp Ser Asp
13125 13130 13135
Asn Trp Val Arg Cys Asn Leu Pro Gln Asn Leu Gln Lys Thr Arg Phe
13140 13145 13150
Glu Val Thr Gly Leu Met Glu Asp Thr Gln Tyr Gln Phe Arg Val Tyr
13155 13160 13165
Ala Val Asn Lys Ile Gly Tyr Ser Asp Pro Ser Asp Val Pro Asp Lys
13170 13175 13180
His Tyr Pro Lys Asp Ile Leu Ile Pro Pro Glu Gly Glu His Asp Ala
13185 13190 13195 13200
Asp Leu Arg Lys Thr Leu Ile Leu Arg Ala Gly Val Thr Met Arg Leu
13205 13210 13215
Tyr Val Pro Val Lys Gly Arg Pro Pro Pro Lys Ile Thr Trp Ser Lys
13220 13225 13230
Pro Asn Val Asn Leu Arg Asp Arg Ile Gly Leu Asp Ile Lys Ser Thr
13235 13240 13245
Asp Phe Asp Thr Phe Leu Arg Cys Glu Asn Val Asn Lys Tyr Asp Ala
13250 13255 13260
Gly Lys Tyr Ile Leu Thr Leu Glu Asn Ser Cys Gly Lys Lys Glu Tyr
13265 13270 13275 13280
Thr Ile Val Val Lys Val Leu Asp Thr Pro Gly Pro Pro Ile Asn Val
13285 13290 13295
Thr Val Lys Glu Ile Ser Lys Asp Ser Ala Tyr Val Thr Trp Glu Pro
13300 13305 13310
Pro Ile Ile Asp Gly Gly Ser Pro Ile Ile Asn Tyr Val Val Gln Lys
13315 13320 13325
Arg Asp Ala Glu Arg Lys Ser Trp Ser Thr Val Thr Thr Glu Cys Ser
13330 13335 13340
Lys Thr Ser Phe Arg Val Pro Asn Leu Glu Glu Gly Lys Ser Tyr Phe
13345 13350 13355 13360
Phe Arg Val Phe Ala Glu Asn Glu Tyr Gly Ile Gly Asp Pro Gly Glu
13365 13370 13375
Thr Arg Asp Ala Val Lys Ala Ser Gln Thr Pro Gly Pro Val Val Asp
13380 13385 13390
Leu Lys Val Arg Ser Val Ser Lys Ser Ser Cys Ser Ile Gly Trp Lys
13395 13400 13405
Lys Pro His Ser Asp Gly Gly Ser Arg Ile Ile Gly Tyr Val Val Asp
13410 13415 13420
Phe Leu Thr Glu Glu Asn Lys Trp Gln Arg Val Met Lys Ser Leu Ser
13425 13430 13435 13440
Leu Gln Tyr Ser Ala Lys Asp Leu Thr Glu Gly Lys Glu Tyr Thr Phe
13445 13450 13455
Arg Val Ser Ala Glu Asn Glu Asn Gly Glu Gly Thr Pro Ser Glu Ile
13460 13465 13470
Thr Val Val Ala Arg Asp Asp Val Val Ala Pro Asp Leu Asp Leu Lys
13475 13480 13485
Gly Leu Pro Asp Leu Cys Tyr Leu Ala Lys Glu Asn Ser Asn Phe Arg
13490 13495 13500
Leu Lys Ile Pro Ile Lys Gly Lys Pro Ala Pro Ser Val Ser Trp Lys
13505 13510 13515 13520
Lys Gly Glu Asp Pro Leu Ala Thr Asp Thr Arg Val Ser Val Glu Ser
13525 13530 13535
Ser Ala Val Asn Thr Thr Leu Ile Val Tyr Asp Cys Gln Lys Ser Asp
13540 13545 13550
Ala Gly Lys Tyr Thr Ile Thr Leu Lys Asn Val Ala Gly Thr Lys Glu
13555 13560 13565
Gly Thr Ile Ser Ile Lys Val Val Gly Lys Pro Gly Ile Pro Thr Gly
13570 13575 13580
Pro Ile Lys Phe Asp Glu Val Thr Ala Glu Ala Met Thr Leu Lys Trp
13585 13590 13595 13600
Ala Pro Pro Lys Asp Asp Gly Gly Ser Glu Ile Thr Asn Tyr Ile Leu
13605 13610 13615
Glu Lys Arg Asp Ser Val Asn Asn Lys Trp Val Thr Cys Ala Ser Ala
13620 13625 13630
Val Gln Lys Thr Thr Phe Arg Val Thr Arg Leu His Glu Gly Met Glu
13635 13640 13645
Tyr Thr Phe Arg Val Ser Ala Glu Asn Lys Tyr Gly Val Gly Glu Gly
13650 13655 13660
Leu Lys Ser Glu Pro Ile Val Ala Arg His Pro Phe Asp Val Pro Asp
13665 13670 13675 13680
Ala Pro Pro Pro Pro Asn Ile Val Asp Val Arg His Asp Ser Val Ser
13685 13690 13695
Leu Thr Trp Thr Asp Pro Lys Lys Thr Gly Gly Ser Pro Ile Thr Gly
13700 13705 13710
Tyr His Leu Glu Phe Lys Glu Arg Asn Ser Leu Leu Trp Lys Arg Ala
13715 13720 13725
Asn Lys Thr Pro Ile Arg Met Arg Asp Phe Lys Val Thr Gly Leu Thr
13730 13735 13740
Glu Gly Leu Glu Tyr Glu Phe Arg Val Met Ala Ile Asn Leu Ala Gly
13745 13750 13755 13760
Val Gly Lys Pro Ser Leu Pro Ser Glu Pro Val Val Ala Leu Asp Pro
13765 13770 13775
Ile Asp Pro Pro Gly Lys Pro Glu Val Ile Asn Ile Thr Arg Asn Ser
13780 13785 13790
Val Thr Leu Ile Trp Thr Glu Pro Lys Tyr Asp Gly Gly His Lys Leu
13795 13800 13805
Thr Gly Tyr Ile Val Glu Lys Arg Asp Leu Pro Ser Lys Ser Trp Met
13810 13815 13820
Lys Ala Asn His Val Asn Val Pro Glu Cys Ala Phe Thr Val Thr Asp
13825 13830 13835 13840
Leu Val Glu Gly Gly Lys Tyr Glu Phe Arg Ile Arg Ala Lys Asn Thr
13845 13850 13855
Ala Gly Ala Ile Ser Ala Pro Ser Glu Ser Thr Glu Thr Ile Ile Cys
13860 13865 13870
Lys Asp Glu Tyr Glu Ala Pro Thr Ile Val Leu Asp Pro Thr Ile Lys
13875 13880 13885
Asp Gly Leu Thr Ile Lys Ala Gly Asp Thr Ile Val Leu Asn Ala Ile
13890 13895 13900
Ser Ile Leu Gly Lys Pro Leu Pro Lys Ser Ser Trp Ser Lys Ala Gly
13905 13910 13915 13920
Lys Asp Ile Arg Pro Ser Asp Ile Thr Gln Ile Thr Ser Thr Pro Thr
13925 13930 13935
Ser Ser Met Leu Thr Ile Lys Tyr Ala Thr Arg Lys Asp Ala Gly Glu
13940 13945 13950
Tyr Thr Ile Thr Ala Thr Asn Pro Phe Gly Thr Lys Val Glu His Val
13955 13960 13965
Lys Val Thr Val Leu Asp Val Pro Gly Pro Pro Gly Pro Val Glu Ile
13970 13975 13980
Ser Asn Val Ser Ala Glu Lys Ala Thr Leu Thr Trp Thr Pro Pro Leu
13985 13990 13995 14000
Glu Asp Gly Gly Ser Pro Ile Lys Ser Tyr Ile Leu Glu Lys Arg Glu
14005 14010 14015
Thr Ser Arg Leu Leu Trp Thr Val Val Ser Glu Asp Ile Gln Ser Cys
14020 14025 14030
Arg His Val Ala Thr Lys Leu Ile Gln Gly Asn Glu Tyr Ile Phe Arg
14035 14040 14045
Val Ser Ala Val Asn His Tyr Gly Lys Gly Glu Pro Val Gln Ser Glu
14050 14055 14060
Pro Val Lys Met Val Asp Arg Phe Gly Pro Pro Gly Pro Pro Glu Lys
14065 14070 14075 14080
Pro Glu Val Ser Asn Val Thr Lys Asn Thr Ala Thr Val Ser Trp Lys
14085 14090 14095
Arg Pro Val Asp Asp Gly Gly Ser Glu Ile Thr Gly Tyr His Val Glu
14100 14105 14110
Arg Arg Glu Lys Lys Ser Leu Arg Trp Val Arg Ala Ile Lys Thr Pro
14115 14120 14125
Val Ser Asp Leu Arg Cys Lys Val Thr Gly Leu Gln Glu Gly Ser Thr
14130 14135 14140
Tyr Glu Phe Arg Val Ser Ala Glu Asn Arg Ala Gly Ile Gly Pro Pro
14145 14150 14155 14160
Ser Glu Ala Ser Asp Ser Val Leu Met Lys Asp Ala Ala Tyr Pro Pro
14165 14170 14175
Gly Pro Pro Ser Asn Pro His Val Thr Asp Thr Thr Lys Lys Ser Ala
14180 14185 14190
Ser Leu Ala Trp Gly Lys Pro His Tyr Asp Gly Gly Leu Glu Ile Thr
14195 14200 14205
Gly Tyr Val Val Glu His Gln Lys Val Gly Asp Glu Ala Trp Ile Lys
14210 14215 14220
Asp Thr Thr Gly Thr Ala Leu Arg Ile Thr Gln Phe Val Val Pro Asp
14225 14230 14235 14240
Leu Gln Thr Lys Glu Lys Tyr Asn Phe Arg Ile Ser Ala Ile Asn Asp
14245 14250 14255
Ala Gly Val Gly Glu Pro Ala Val Ile Pro Asp Val Glu Ile Val Glu
14260 14265 14270
Arg Glu Met Ala Pro Asp Phe Glu Leu Asp Ala Glu Leu Arg Arg Thr
14275 14280 14285
Leu Val Val Arg Ala Gly Leu Ser Ile Arg Ile Phe Val Pro Ile Lys
14290 14295 14300
Gly Arg Pro Ala Pro Glu Val Thr Trp Thr Lys Asp Asn Ile Asn Leu
14305 14310 14315 14320
Lys Asn Arg Ala Asn Ile Glu Asn Thr Glu Ser Phe Thr Leu Leu Ile
14325 14330 14335
Ile Pro Glu Cys Asn Arg Tyr Asp Thr Gly Lys Phe Val Met Thr Ile
14340 14345 14350
Glu Asn Pro Ala Gly Lys Lys Ser Gly Phe Val Asn Val Arg Val Leu
14355 14360 14365
Asp Thr Pro Gly Pro Val Leu Asn Leu Arg Pro Thr Asp Ile Thr Lys
14370 14375 14380
Asp Ser Val Thr Leu His Trp Asp Leu Pro Leu Ile Asp Gly Gly Ser
14385 14390 14395 14400
Arg Ile Thr Asn Tyr Ile Val Glu Lys Arg Glu Ala Thr Arg Lys Ser
14405 14410 14415
Tyr Ser Thr Ala Thr Thr Lys Cys His Lys Cys Thr Tyr Lys Val Thr
14420 14425 14430
Gly Leu Ser Glu Gly Cys Glu Tyr Phe Phe Arg Val Met Ala Glu Asn
14435 14440 14445
Glu Tyr Gly Ile Gly Glu Pro Thr Glu Thr Thr Glu Pro Val Lys Ala
14450 14455 14460
Ser Glu Ala Pro Ser Pro Pro Asp Ser Leu Asn Ile Met Asp Ile Thr
14465 14470 14475 14480
Lys Ser Thr Val Ser Leu Ala Trp Pro Lys Pro Lys His Asp Gly Gly
14485 14490 14495
Ser Lys Ile Thr Gly Tyr Val Ile Glu Ala Gln Arg Lys Gly Ser Asp
14500 14505 14510
Gln Trp Thr His Ile Thr Thr Val Lys Gly Leu Glu Cys Val Val Arg
14515 14520 14525
Asn Leu Thr Glu Gly Glu Glu Tyr Thr Phe Gln Val Met Ala Val Asn
14530 14535 14540
Ser Ala Gly Arg Ser Ala Pro Arg Glu Ser Arg Pro Val Ile Val Lys
14545 14550 14555 14560
Glu Gln Thr Met Leu Pro Glu Leu Asp Leu Arg Gly Ile Tyr Gln Lys
14565 14570 14575
Leu Val Ile Ala Lys Ala Gly Asp Asn Ile Lys Val Glu Ile Pro Val
14580 14585 14590
Leu Gly Arg Pro Lys Pro Thr Val Thr Trp Lys Lys Gly Asp Gln Ile
14595 14600 14605
Leu Lys Gln Thr Gln Arg Val Asn Phe Glu Thr Thr Ala Thr Ser Thr
14610 14615 14620
Ile Leu Asn Ile Asn Glu Cys Val Arg Ser Asp Ser Gly Pro Tyr Pro
14625 14630 14635 14640
Leu Thr Ala Arg Asn Ile Val Gly Glu Val Gly Asp Val Ile Thr Ile
14645 14650 14655
Gln Val His Asp Ile Pro Gly Pro Pro Thr Gly Pro Ile Lys Phe Asp
14660 14665 14670
Glu Val Ser Ser Asp Phe Val Thr Phe Ser Trp Asp Pro Pro Glu Asn
14675 14680 14685
Asp Gly Gly Val Pro Ile Ser Asn Tyr Val Val Glu Met Arg Gln Thr
14690 14695 14700
Asp Ser Thr Thr Trp Val Glu Leu Ala Thr Thr Val Ile Arg Thr Thr
14705 14710 14715 14720
Tyr Lys Ala Thr Arg Leu Thr Thr Gly Leu Glu Tyr Gln Phe Arg Val
14725 14730 14735
Lys Ala Gln Asn Arg Tyr Gly Val Gly Pro Gly Ile Thr Ser Ala Trp
14740 14745 14750
Ile Val Ala Asn Tyr Pro Phe Lys Val Pro Gly Pro Pro Gly Thr Pro
14755 14760 14765
Gln Val Thr Ala Val Thr Lys Asp Ser Met Thr Ile Ser Trp His Glu
14770 14775 14780
Pro Leu Ser Asp Gly Gly Ser Pro Ile Leu Gly Tyr His Val Glu Arg
14785 14790 14795 14800
Lys Glu Arg Asn Gly Ile Leu Trp Gln Thr Val Ser Lys Ala Leu Val
14805 14810 14815
Pro Gly Asn Ile Phe Lys Ser Ser Gly Leu Thr Asp Gly Ile Ala Tyr
14820 14825 14830
Glu Phe Arg Val Ile Ala Glu Asn Met Ala Gly Lys Ser Lys Pro Ser
14835 14840 14845
Lys Pro Ser Glu Pro Met Leu Ala Leu Asp Pro Ile Asp Pro Pro Gly
14850 14855 14860
Lys Pro Val Pro Leu Asn Ile Thr Arg His Thr Val Thr Leu Lys Trp
14865 14870 14875 14880
Ala Lys Pro Glu Tyr Thr Gly Gly Phe Lys Ile Thr Ser Tyr Ile Val
14885 14890 14895
Glu Lys Arg Asp Leu Pro Asn Gly Arg Trp Leu Lys Ala Asn Phe Ser
14900 14905 14910
Asn Ile Leu Glu Asn Glu Phe Thr Val Ser Gly Leu Thr Glu Asp Ala
14915 14920 14925
Ala Tyr Glu Phe Arg Val Ile Ala Lys Asn Ala Ala Gly Ala Ile Ser
14930 14935 14940
Pro Pro Ser Glu Pro Ser Asp Ala Ile Thr Cys Arg Asp Asp Val Glu
14945 14950 14955 14960
Ala Pro Lys Ile Lys Val Asp Val Lys Phe Lys Asp Thr Val Ile Leu
14965 14970 14975
Lys Ala Gly Glu Ala Phe Arg Leu Glu Ala Asp Val Ser Gly Arg Pro
14980 14985 14990
Pro Pro Thr Met Glu Trp Ser Lys Asp Gly Lys Glu Leu Glu Gly Thr
14995 15000 15005
Ala Lys Leu Glu Ile Lys Ile Ala Asp Phe Ser Thr Asn Leu Val Asn
15010 15015 15020
Lys Asp Ser Thr Arg Arg Asp Ser Gly Ala Tyr Thr Leu Thr Ala Thr
15025 15030 15035 15040
Asn Pro Gly Gly Phe Ala Lys His Ile Phe Asn Val Lys Val Leu Asp
15045 15050 15055
Arg Pro Gly Pro Pro Glu Gly Pro Leu Ala Val Thr Glu Val Thr Ser
15060 15065 15070
Glu Lys Cys Val Leu Ser Trp Phe Pro Pro Leu Asp Asp Gly Gly Ala
15075 15080 15085
Lys Ile Asp His Tyr Ile Val Gln Lys Arg Glu Thr Ser Arg Leu Ala
15090 15095 15100
Trp Thr Asn Val Ala Ser Glu Val Gln Val Thr Lys Leu Lys Val Thr
15105 15110 15115 15120
Lys Leu Leu Lys Gly Asn Glu Tyr Ile Phe Arg Val Met Ala Val Asn
15125 15130 15135
Lys Tyr Gly Val Gly Glu Pro Leu Glu Ser Glu Pro Val Leu Ala Val
15140 15145 15150
Asn Pro Tyr Gly Pro Pro Asp Pro Pro Lys Asn Pro Glu Val Thr Thr
15155 15160 15165
Ile Thr Lys Asp Ser Met Val Val Cys Trp Gly His Pro Asp Ser Asp
15170 15175 15180
Gly Gly Ser Glu Ile Ile Asn Tyr Ile Val Glu Arg Arg Asp Lys Ala
15185 15190 15195 15200
Gly Gln Arg Trp Ile Lys Cys Asn Lys Lys Thr Leu Thr Asp Leu Arg
15205 15210 15215
Tyr Lys Val Ser Gly Leu Thr Glu Gly His Glu Tyr Glu Phe Arg Ile
15220 15225 15230
Met Ala Glu Asn Ala Ala Gly Ile Ser Ala Pro Ser Pro Thr Ser Pro
15235 15240 15245
Phe Tyr Lys Ala Cys Asp Thr Val Phe Lys Pro Gly Pro Pro Gly Asn
15250 15255 15260
Pro Arg Val Leu Asp Thr Ser Arg Ser Ser Ile Ser Ile Ala Trp Asn
15265 15270 15275 15280
Lys Pro Ile Tyr Asp Gly Gly Ser Glu Ile Thr Gly Tyr Met Val Glu
15285 15290 15295
Ile Ala Leu Pro Glu Glu Asp Glu Trp Gln Ile Val Thr Pro Pro Ala
15300 15305 15310
Gly Leu Lys Ala Thr Ser Tyr Thr Ile Thr Gly Leu Thr Glu Asn Gln
15315 15320 15325
Glu Tyr Lys Ile Arg Ile Tyr Ala Met Asn Ser Glu Gly Leu Gly Glu
15330 15335 15340
Pro Ala Leu Val Pro Gly Thr Pro Lys Ala Glu Asp Arg Met Leu Pro
15345 15350 15355 15360
Pro Glu Ile Glu Leu Asp Ala Asp Leu Arg Lys Val Val Thr Ile Arg
15365 15370 15375
Ala Cys Cys Thr Leu Arg Leu Phe Val Pro Ile Lys Gly Arg Pro Asp
15380 15385 15390
Pro Glu Val Lys Trp Ala Arg Asp His Gly Glu Ser Leu Asp Lys Ala
15395 15400 15405
Ser Ile Glu Ser Ala Ser Ser Tyr Thr Leu Leu Ile Val Gly Asn Val
15410 15415 15420
Asn Arg Phe Asp Ser Gly Lys Tyr Ile Leu Thr Val Glu Asn Ser Ser
15425 15430 15435 15440
Gly Ser Lys Ser Ala Phe Val Asn Val Arg Val Leu Asp Thr Pro Gly
15445 15450 15455
Pro Pro Gln Asp Leu Lys Val Lys Glu Val Thr Lys Thr Ser Val Thr
15460 15465 15470
Leu Thr Trp Asp Pro Pro Leu Leu Asp Gly Gly Ser Lys Ile Lys Asn
15475 15480 15485
Tyr Ile Val Glu Lys Arg Glu Ser Thr Arg Lys Ala Tyr Ser Thr Val
15490 15495 15500
Ala Thr Asn Cys His Lys Thr Ser Trp Lys Val Asp Gln Leu Gln Glu
15505 15510 15515 15520
Gly Cys Ser Tyr Tyr Phe Arg Val Leu Ala Glu Asn Glu Tyr Gly Ile
15525 15530 15535
Gly Leu Pro Ala Glu Thr Ala Glu Ser Val Lys Ala Ser Glu Arg Pro
15540 15545 15550
Leu Pro Pro Gly Lys Ile Thr Leu Met Asp Val Thr Arg Asn Ser Val
15555 15560 15565
Ser Leu Ser Trp Glu Lys Pro Glu His Asp Gly Gly Ser Arg Ile Leu
15570 15575 15580
Gly Tyr Ile Val Glu Met Gln Thr Lys Gly Ser Asp Lys Trp Ala Thr
15585 15590 15595 15600
Cys Ala Thr Val Lys Val Thr Glu Ala Thr Ile Thr Gly Leu Ile Gln
15605 15610 15615
Gly Glu Glu Tyr Ser Phe Arg Val Ser Ala Gln Asn Glu Lys Gly Ile
15620 15625 15630
Ser Asp Pro Arg Gln Leu Ser Val Pro Val Ile Ala Lys Asp Leu Val
15635 15640 15645
Ile Pro Pro Ala Phe Lys Leu Leu Phe Asn Thr Phe Thr Val Leu Ala
15650 15655 15660
Gly Glu Asp Leu Lys Val Asp Val Pro Phe Ile Gly Arg Pro Thr Pro
15665 15670 15675 15680
Ala Val Thr Trp His Lys Asp Asn Val Pro Leu Lys Gln Thr Thr Arg
15685 15690 15695
Val Asn Ala Glu Ser Thr Glu Asn Asn Ser Leu Leu Thr Ile Lys Asp
15700 15705 15710
Ala Cys Arg Glu Asp Val Gly His Tyr Val Val Lys Leu Thr Asn Ser
15715 15720 15725
Ala Gly Glu Ala Ile Glu Thr Leu Asn Val Ile Val Leu Asp Lys Pro
15730 15735 15740
Gly Pro Pro Thr Gly Pro Val Lys Met Asp Glu Val Thr Ala Asp Ser
15745 15750 15755 15760
Ile Thr Leu Ser Trp Gly Pro Pro Lys Tyr Asp Gly Gly Ser Ser Ile
15765 15770 15775
Asn Asn Tyr Ile Val Glu Lys Arg Asp Thr Ser Thr Thr Thr Trp Gln
15780 15785 15790
Ile Val Ser Ala Thr Val Ala Arg Thr Thr Ile Lys Ala Cys Arg Leu
15795 15800 15805
Lys Thr Gly Cys Glu Tyr Gln Phe Arg Ile Ala Ala Glu Asn Arg Tyr
15810 15815 15820
Gly Lys Ser Thr Tyr Leu Asn Ser Glu Pro Thr Val Ala Gln Tyr Pro
15825 15830 15835 15840
Phe Lys Val Pro Gly Pro Pro Gly Thr Pro Val Val Thr Leu Ser Ser
15845 15850 15855
Arg Asp Ser Met Glu Val Gln Trp Asn Glu Pro Ile Ser Asp Gly Gly
15860 15865 15870
Ser Arg Val Ile Gly Tyr His Leu Glu Arg Lys Glu Arg Asn Ser Ile
15875 15880 15885
Leu Trp Val Lys Leu Asn Lys Thr Pro Ile Pro Gln Thr Lys Phe Lys
15890 15895 15900
Thr Thr Gly Leu Glu Glu Gly Val Glu Tyr Glu Phe Arg Val Ser Ala
15905 15910 15915 15920
Glu Asn Ile Val Gly Ile Gly Lys Pro Ser Lys Val Ser Glu Cys Tyr
15925 15930 15935
Val Ala Arg Asp Pro Cys Asp Pro Pro Gly Arg Pro Glu Ala Ile Ile
15940 15945 15950
Val Thr Arg Asn Ser Val Thr Leu Gln Trp Lys Lys Pro Thr Tyr Asp
15955 15960 15965
Gly Gly Ser Lys Ile Thr Gly Tyr Ile Val Glu Lys Lys Glu Leu Pro
15970 15975 15980
Glu Gly Arg Trp Met Lys Ala Ser Phe Thr Asn Ile Ile Asp Thr His
15985 15990 15995 16000
Phe Glu Val Thr Gly Leu Val Glu Asp His Arg Tyr Glu Phe Arg Val
16005 16010 16015
Ile Ala Arg Asn Ala Ala Gly Val Phe Ser Glu Pro Ser Glu Ser Thr
16020 16025 16030
Gly Ala Ile Thr Ala Arg Asp Glu Val Asp Pro Pro Arg Ile Ser Met
16035 16040 16045
Asp Pro Lys Tyr Lys Asp Thr Ile Val Val His Ala Gly Glu Ser Phe
16050 16055 16060
Lys Val Asp Ala Asp Ile Tyr Gly Lys Pro Ile Pro Thr Ile Gln Trp
16065 16070 16075 16080
Ile Lys Gly Asp Gln Glu Leu Ser Asn Thr Ala Arg Leu Glu Ile Lys
16085 16090 16095
Ser Thr Asp Phe Ala Thr Ser Leu Ser Val Lys Asp Ala Val Arg Val
16100 16105 16110
Asp Ser Gly Asn Tyr Ile Leu Lys Ala Lys Asn Val Ala Gly Glu Arg
16115 16120 16125
Ser Val Thr Val Asn Val Lys Val Leu Asp Arg Pro Gly Pro Pro Glu
16130 16135 16140
Gly Pro Val Val Ile Ser Gly Val Thr Ala Glu Lys Cys Thr Leu Ala
16145 16150 16155 16160
Trp Lys Pro Pro Leu Gln Asp Gly Gly Ser Asp Ile Ile Asn Tyr Ile
16165 16170 16175
Val Glu Arg Arg Glu Thr Ser Arg Leu Val Trp Thr Val Val Asp Ala
16180 16185 16190
Asn Val Gln Thr Leu Ser Cys Lys Val Thr Lys Leu Leu Glu Gly Asn
16195 16200 16205
Glu Tyr Thr Phe Arg Ile Met Ala Val Asn Lys Tyr Gly Val Gly Glu
16210 16215 16220
Pro Leu Glu Ser Glu Pro Val Val Ala Lys Asn Pro Phe Val Val Pro
16225 16230 16235 16240
Asp Ala Pro Lys Ala Pro Glu Val Thr Thr Val Thr Lys Asp Ser Met
16245 16250 16255
Ile Val Val Trp Glu Arg Pro Ala Ser Asp Gly Gly Ser Glu Ile Leu
16260 16265 16270
Gly Tyr Val Leu Glu Lys Arg Asp Lys Glu Gly Ile Arg Trp Thr Arg
16275 16280 16285
Cys His Lys Arg Leu Ile Gly Glu Leu Arg Leu Arg Val Thr Gly Leu
16290 16295 16300
Ile Glu Asn His Asp Tyr Glu Phe Arg Val Ser Ala Glu Asn Ala Ala
16305 16310 16315 16320
Gly Leu Ser Glu Pro Ser Pro Pro Ser Ala Tyr Gln Lys Ala Cys Asp
16325 16330 16335
Pro Ile Tyr Lys Pro Gly Pro Pro Asn Asn Pro Lys Val Ile Asp Ile
16340 16345 16350
Thr Arg Ser Ser Val Phe Leu Ser Trp Ser Lys Pro Ile Tyr Asp Gly
16355 16360 16365
Gly Cys Glu Ile Gln Gly Tyr Ile Val Glu Lys Cys Asp Val Asn Val
16370 16375 16380
Gly Glu Trp Thr Met Cys Thr Pro Pro Thr Gly Ile Asn Lys Thr Asn
16385 16390 16395 16400
Ile Glu Val Glu Lys Leu Leu Glu Lys His Glu Tyr Asn Phe Arg Ile
16405 16410 16415
Cys Ala Ile Asn Lys Ala Gly Val Gly Glu His Ala Asp Val Pro Gly
16420 16425 16430
Pro Ile Ile Val Glu Glu Lys Leu Glu Ala Pro Asp Ile Asp Leu Asp
16435 16440 16445
Leu Glu Leu Arg Lys Ile Ile Asn Ile Arg Ala Gly Gly Ser Leu Arg
16450 16455 16460
Leu Phe Val Pro Ile Lys Gly Arg Pro Thr Pro Glu Val Lys Trp Gly
16465 16470 16475 16480
Lys Val Asp Gly Glu Ile Arg Asp Ala Ala Ile Ile Asp Val Thr Ser
16485 16490 16495
Ser Phe Thr Ser Leu Val Leu Asp Asn Val Asn Arg Tyr Asp Ser Gly
16500 16505 16510
Lys Tyr Thr Leu Thr Leu Glu Asn Ser Ser Gly Thr Lys Ser Ala Phe
16515 16520 16525
Val Thr Val Arg Val Leu Asp Thr Pro Ser Pro Pro Val Asn Leu Lys
16530 16535 16540
Val Thr Glu Ile Thr Lys Asp Ser Val Ser Ile Thr Trp Glu Pro Pro
16545 16550 16555 16560
Leu Leu Asp Gly Gly Ser Lys Ile Lys Asn Tyr Ile Val Glu Lys Arg
16565 16570 16575
Glu Ala Thr Arg Lys Ser Tyr Ala Ala Val Val Thr Asn Cys His Lys
16580 16585 16590
Asn Ser Trp Lys Ile Asp Gln Leu Gln Glu Gly Cys Ser Tyr Tyr Phe
16595 16600 16605
Arg Val Thr Ala Glu Asn Glu Tyr Gly Ile Gly Leu Pro Ala Gln Thr
16610 16615 16620
Ala Asp Pro Ile Lys Val Ala Glu Val Pro Gln Pro Pro Gly Lys Ile
16625 16630 16635 16640
Thr Val Asp Asp Val Thr Arg Asn Ser Val Ser Leu Ser Trp Thr Lys
16645 16650 16655
Pro Glu His Asp Gly Gly Ser Lys Ile Ile Gln Tyr Ile Val Glu Met
16660 16665 16670
Gln Ala Lys His Ser Glu Lys Trp Ser Glu Cys Ala Arg Val Lys Ser
16675 16680 16685
Leu Gln Ala Val Ile Thr Asn Leu Thr Gln Gly Glu Glu Tyr Leu Phe
16690 16695 16700
Arg Val Val Ala Val Asn Glu Lys Gly Arg Ser Asp Pro Arg Ser Leu
16705 16710 16715 16720
Ala Val Pro Ile Val Ala Lys Asp Leu Val Ile Glu Pro Asp Val Lys
16725 16730 16735
Pro Ala Phe Ser Ser Tyr Ser Val Gln Val Gly Gln Asp Leu Lys Met
16740 16745 16750
Glu Val Pro Ile Ser Gly Arg Pro Lys Pro Thr Ile Thr Trp Thr Lys
16755 16760 16765
Asp Gly Leu Pro Leu Lys Gln Thr Thr Arg Ile Asn Val Thr Asp Ser
16770 16775 16780
Leu Asp Leu Thr Thr Leu Ser Ile Lys Glu Thr His Lys Asp Asp Gly
16785 16790 16795 16800
Gly Gln Tyr Gly Ile Thr Val Ala Asn Val Val Gly Gln Lys Thr Ala
16805 16810 16815
Ser Ile Glu Ile Val Thr Leu Asp Lys Pro Asp Pro Pro Lys Gly Pro
16820 16825 16830
Val Lys Phe Asp Asp Val Ser Ala Glu Ser Ile Thr Leu Ser Trp Asn
16835 16840 16845
Pro Pro Leu Tyr Thr Gly Gly Cys Gln Ile Thr Asn Tyr Ile Val Gln
16850 16855 16860
Lys Arg Asp Thr Thr Thr Thr Val Trp Asp Val Val Ser Ala Thr Val
16865 16870 16875 16880
Ala Arg Thr Thr Leu Lys Val Thr Lys Leu Lys Thr Gly Thr Glu Tyr
16885 16890 16895
Gln Phe Arg Ile Phe Ala Glu Asn Arg Tyr Gly Gln Ser Phe Ala Leu
16900 16905 16910
Glu Ser Asp Pro Ile Val Ala Gln Tyr Pro Tyr Lys Glu Pro Gly Pro
16915 16920 16925
Pro Gly Thr Pro Phe Ala Thr Ala Ile Ser Lys Asp Ser Met Val Ile
16930 16935 16940
Gln Trp His Glu Pro Val Asn Asn Gly Gly Ser Pro Val Ile Gly Tyr
16945 16950 16955 16960
His Leu Glu Arg Lys Glu Arg Asn Ser Ile Leu Trp Thr Lys Val Asn
16965 16970 16975
Lys Thr Ile Ile His Asp Thr Gln Phe Lys Ala Gln Asn Leu Glu Glu
16980 16985 16990
Gly Ile Glu Tyr Glu Phe Arg Val Tyr Ala Glu Asn Ile Val Gly Val
16995 17000 17005
Gly Lys Ala Ser Lys Asn Ser Glu Cys Tyr Val Ala Arg Asp Pro Cys
17010 17015 17020
Asp Pro Pro Gly Thr Pro Glu Pro Ile Met Val Lys Arg Asn Glu Ile
17025 17030 17035 17040
Thr Leu Gln Trp Thr Lys Pro Val Tyr Asp Gly Gly Ser Met Ile Thr
17045 17050 17055
Gly Tyr Ile Val Glu Lys Arg Asp Leu Pro Asp Gly Arg Trp Met Lys
17060 17065 17070
Ala Ser Phe Thr Asn Val Ile Glu Thr Gln Phe Thr Val Ser Gly Leu
17075 17080 17085
Thr Glu Asp Gln Arg Tyr Glu Phe Arg Val Ile Ala Lys Asn Ala Ala
17090 17095 17100
Gly Ala Ile Ser Lys Pro Ser Asp Ser Thr Gly Pro Ile Thr Ala Lys
17105 17110 17115 17120
Asp Glu Val Glu Leu Pro Arg Ile Ser Met Asp Pro Lys Phe Arg Asp
17125 17130 17135
Thr Ile Val Val Asn Ala Gly Glu Thr Phe Arg Leu Glu Ala Asp Val
17140 17145 17150
His Gly Lys Pro Leu Pro Thr Ile Glu Trp Leu Arg Gly Asp Lys Glu
17155 17160 17165
Ile Glu Glu Ser Ala Arg Cys Glu Ile Lys Asn Thr Asp Phe Lys Ala
17170 17175 17180
Leu Leu Ile Val Lys Asp Ala Ile Arg Ile Asp Gly Gly Gln Tyr Ile
17185 17190 17195 17200
Leu Arg Ala Ser Asn Val Ala Gly Ser Lys Ser Phe Pro Val Asn Val
17205 17210 17215
Lys Val Leu Asp Arg Pro Gly Pro Pro Glu Gly Pro Val Gln Val Thr
17220 17225 17230
Gly Val Thr Ser Glu Lys Cys Ser Leu Thr Trp Ser Pro Pro Leu Gln
17235 17240 17245
Asp Gly Gly Ser Asp Ile Ser His Tyr Val Val Glu Lys Arg Glu Thr
17250 17255 17260
Ser Arg Leu Ala Trp Thr Val Val Ala Ser Glu Val Val Thr Asn Ser
17265 17270 17275 17280
Leu Lys Val Thr Lys Leu Leu Glu Gly Asn Glu Tyr Val Phe Arg Ile
17285 17290 17295
Met Ala Val Asn Lys Tyr Gly Val Gly Glu Pro Leu Glu Ser Ala Pro
17300 17305 17310
Val Leu Met Lys Asn Pro Phe Val Leu Pro Gly Pro Pro Lys Ser Leu
17315 17320 17325
Glu Val Thr Asn Ile Ala Lys Asp Ser Met Thr Val Cys Trp Asn Arg
17330 17335 17340
Pro Asp Ser Asp Gly Gly Ser Glu Ile Ile Gly Tyr Ile Val Glu Lys
17345 17350 17355 17360
Arg Asp Arg Ser Gly Ile Arg Trp Ile Lys Cys Asn Lys Arg Arg Ile
17365 17370 17375
Thr Asp Leu Arg Leu Arg Val Thr Gly Leu Thr Glu Asp His Glu Tyr
17380 17385 17390
Glu Phe Arg Val Ser Ala Glu Asn Ala Ala Gly Val Gly Glu Pro Ser
17395 17400 17405
Pro Ala Thr Val Tyr Tyr Lys Ala Cys Asp Pro Val Phe Lys Pro Gly
17410 17415 17420
Pro Pro Thr Asn Ala His Ile Val Asp Thr Thr Lys Asn Ser Ile Thr
17425 17430 17435 17440
Leu Ala Trp Gly Lys Pro Ile Tyr Asp Gly Gly Ser Glu Ile Leu Gly
17445 17450 17455
Tyr Val Val Glu Ile Cys Lys Ala Asp Glu Glu Glu Trp Gln Ile Val
17460 17465 17470
Thr Pro Gln Thr Gly Leu Arg Val Thr Arg Phe Glu Ile Ser Lys Leu
17475 17480 17485
Thr Glu His Gln Glu Tyr Lys Ile Arg Val Cys Ala Leu Asn Lys Val
17490 17495 17500
Gly Leu Gly Glu Ala Thr Ser Val Pro Gly Thr Val Lys Pro Glu Asp
17505 17510 17515 17520
Lys Leu Glu Ala Pro Glu Leu Asp Leu Asp Ser Glu Leu Arg Lys Gly
17525 17530 17535
Ile Val Val Arg Ala Gly Gly Ser Ala Arg Ile His Ile Pro Phe Lys
17540 17545 17550
Gly Arg Pro Met Pro Glu Ile Thr Trp Ser Arg Glu Glu Gly Glu Phe
17555 17560 17565
Thr Asp Lys Val Gln Ile Glu Lys Gly Val Asn Tyr Thr Gln Leu Ser
17570 17575 17580
Ile Asp Asn Cys Asp Arg Asn Asp Ala Gly Lys Tyr Ile Leu Lys Leu
17585 17590 17595 17600
Glu Asn Ser Ser Gly Ser Lys Ser Ala Phe Val Thr Val Lys Val Leu
17605 17610 17615
Asp Thr Pro Gly Pro Pro Gln Asn Leu Ala Val Lys Glu Val Arg Lys
17620 17625 17630
Asp Ser Ala Phe Leu Val Trp Glu Pro Pro Ile Ile Asp Gly Gly Ala
17635 17640 17645
Lys Val Lys Asn Tyr Val Ile Asp Lys Arg Glu Ser Thr Arg Lys Ala
17650 17655 17660
Tyr Ala Asn Val Ser Ser Lys Cys Ser Lys Thr Ser Phe Lys Val Glu
17665 17670 17675 17680
Asn Leu Thr Glu Gly Ala Ile Tyr Tyr Phe Arg Val Met Ala Glu Asn
17685 17690 17695
Glu Phe Gly Val Gly Val Pro Val Glu Thr Val Asp Ala Val Lys Ala
17700 17705 17710
Ala Glu Pro Pro Ser Pro Pro Gly Lys Val Thr Leu Thr Asp Val Ser
17715 17720 17725
Gln Thr Ser Ala Ser Leu Met Trp Glu Lys Pro Glu His Asp Gly Gly
17730 17735 17740
Ser Arg Val Leu Gly Tyr Val Val Glu Met Gln Pro Lys Gly Thr Glu
17745 17750 17755 17760
Lys Trp Ser Ile Val Ala Glu Ser Lys Val Cys Asn Ala Val Val Thr
17765 17770 17775
Gly Leu Ser Ser Gly Gln Glu Tyr Gln Phe Arg Val Lys Ala Tyr Asn
17780 17785 17790
Glu Lys Gly Lys Ser Asp Pro Arg Val Leu Gly Val Pro Val Ile Ala
17795 17800 17805
Lys Asp Leu Thr Ile Gln Pro Ser Leu Lys Leu Pro Phe Asn Thr Tyr
17810 17815 17820
Ser Ile Gln Ala Gly Glu Asp Leu Lys Ile Glu Ile Pro Val Ile Gly
17825 17830 17835 17840
Arg Pro Arg Pro Asn Ile Ser Trp Val Lys Asp Gly Glu Pro Leu Lys
17845 17850 17855
Gln Thr Thr Arg Val Asn Val Glu Glu Thr Ala Thr Ser Thr Val Leu
17860 17865 17870
His Ile Lys Glu Gly Asn Lys Asp Asp Phe Gly Lys Tyr Thr Val Thr
17875 17880 17885
Ala Thr Asn Ser Ala Gly Thr Ala Thr Glu Asn Leu Ser Val Ile Val
17890 17895 17900
Leu Glu Lys Pro Gly Pro Pro Val Gly Pro Val Arg Phe Asp Glu Val
17905 17910 17915 17920
Ser Ala Asp Phe Val Val Ile Ser Trp Glu Pro Pro Ala Tyr Thr Gly
17925 17930 17935
Gly Cys Gln Ile Ser Asn Tyr Ile Val Glu Lys Arg Asp Thr Thr Thr
17940 17945 17950
Thr Thr Trp His Met Val Ser Ala Thr Val Ala Arg Thr Thr Ile Lys
17955 17960 17965
Ile Thr Lys Leu Lys Thr Gly Thr Glu Tyr Gln Phe Arg Ile Phe Ala
17970 17975 17980
Glu Asn Arg Tyr Gly Lys Ser Ala Pro Leu Asp Ser Lys Ala Val Ile
17985 17990 17995 18000
Val Gln Tyr Pro Phe Lys Glu Pro Gly Pro Pro Gly Thr Pro Phe Val
18005 18010 18015
Thr Ser Ile Ser Lys Asp Gln Met Leu Val Gln Trp His Glu Pro Val
18020 18025 18030
Asn Asp Gly Gly Thr Lys Ile Ile Gly Tyr His Leu Glu Gln Lys Glu
18035 18040 18045
Lys Asn Ser Ile Leu Trp Val Lys Leu Asn Lys Thr Pro Ile Gln Asp
18050 18055 18060
Thr Lys Phe Lys Thr Thr Gly Leu Asp Glu Gly Leu Glu Tyr Glu Phe
18065 18070 18075 18080
Lys Val Ser Ala Glu Asn Ile Val Gly Ile Gly Lys Pro Ser Lys Val
18085 18090 18095
Ser Glu Cys Phe Val Ala Arg Asp Pro Cys Asp Pro Pro Gly Arg Pro
18100 18105 18110
Glu Ala Ile Val Ile Thr Arg Asn Asn Val Thr Leu Lys Trp Lys Lys
18115 18120 18125
Pro Ala Tyr Asp Gly Gly Ser Lys Ile Thr Gly Tyr Ile Val Glu Lys
18130 18135 18140
Lys Asp Leu Pro Asp Gly Arg Trp Met Lys Ala Ser Phe Thr Asn Val
18145 18150 18155 18160
Leu Glu Thr Glu Phe Thr Val Ser Gly Leu Val Glu Asp Gln Arg Tyr
18165 18170 18175
Glu Phe Arg Val Ile Ala Arg Asn Ala Ala Gly Asn Phe Ser Glu Pro
18180 18185 18190
Ser Asp Ser Ser Gly Ala Ile Thr Ala Arg Asp Glu Ile Asp Ala Pro
18195 18200 18205
Asn Ala Ser Leu Asp Pro Lys Tyr Lys Asp Val Ile Val Val His Ala
18210 18215 18220
Gly Glu Thr Phe Val Leu Glu Ala Asp Ile Arg Gly Lys Pro Ile Pro
18225 18230 18235 18240
Asp Val Val Trp Ser Lys Asp Gly Lys Glu Leu Glu Glu Thr Ala Ala
18245 18250 18255
Arg Met Glu Ile Lys Ser Thr Ile Gln Lys Thr Thr Leu Val Val Lys
18260 18265 18270
Asp Cys Ile Arg Thr Asp Gly Gly Gln Tyr Ile Leu Lys Leu Ser Asn
18275 18280 18285
Val Gly Gly Thr Lys Ser Ile Pro Ile Thr Val Lys Val Leu Asp Arg
18290 18295 18300
Pro Gly Ser Pro Glu Gly Pro Leu Lys Val Thr Gly Val Thr Ala Glu
18305 18310 18315 18320
Lys Cys Tyr Leu Ala Trp Asn Pro Pro Leu Gln Asp Gly Gly Ala Asn
18325 18330 18335
Ile Ser His Tyr Ile Ile Glu Lys Arg Glu Thr Ser Arg Leu Ser Trp
18340 18345 18350
Thr Gln Val Ser Thr Glu Val Gln Ala Leu Asn Tyr Lys Val Thr Lys
18355 18360 18365
Leu Leu Pro Gly Asn Glu Tyr Ile Phe Arg Val Met Ala Val Asn Lys
18370 18375 18380
Tyr Gly Ile Gly Glu Pro Leu Glu Ser Gly Pro Val Thr Ala Cys Asn
18385 18390 18395 18400
Pro Tyr Lys Pro Pro Gly Pro Pro Ser Thr Pro Glu Val Ser Ala Ile
18405 18410 18415
Thr Lys Asp Ser Met Val Val Thr Trp Ala Arg Pro Val Asp Asp Gly
18420 18425 18430
Gly Thr Glu Ile Glu Gly Tyr Ile Leu Glu Lys Arg Asp Lys Glu Gly
18435 18440 18445
Val Arg Trp Thr Lys Cys Asn Lys Lys Thr Leu Thr Asp Leu Arg Leu
18450 18455 18460
Arg Val Thr Gly Leu Thr Glu Gly His Ser Tyr Glu Phe Arg Val Ala
18465 18470 18475 18480
Ala Glu Asn Ala Ala Gly Val Gly Glu Pro Ser Glu Pro Ser Val Phe
18485 18490 18495
Tyr Arg Ala Cys Asp Ala Leu Tyr Pro Pro Gly Pro Pro Ser Asn Pro
18500 18505 18510
Lys Val Thr Asp Thr Ser Arg Ser Ser Val Ser Leu Ala Trp Ser Lys
18515 18520 18525
Pro Ile Tyr Asp Gly Gly Ala Pro Val Lys Gly Tyr Val Val Glu Val
18530 18535 18540
Lys Glu Ala Ala Ala Asp Glu Trp Thr Thr Cys Thr Pro Pro Thr Gly
18545 18550 18555 18560
Leu Gln Gly Lys Gln Phe Thr Val Thr Lys Leu Lys Glu Asn Thr Glu
18565 18570 18575
Tyr Asn Phe Arg Ile Cys Ala Ile Asn Ser Glu Gly Val Gly Glu Pro
18580 18585 18590
Ala Thr Leu Pro Gly Ser Val Val Ala Gln Glu Arg Ile Glu Pro Pro
18595 18600 18605
Glu Ile Glu Leu Asp Ala Asp Leu Arg Lys Val Val Val Leu Arg Ala
18610 18615 18620
Ser Ala Thr Leu Arg Leu Phe Val Thr Ile Lys Gly Arg Pro Glu Pro
18625 18630 18635 18640
Glu Val Lys Trp Glu Lys Ala Glu Gly Ile Leu Thr Asp Arg Ala Gln
18645 18650 18655
Ile Glu Val Thr Ser Ser Phe Thr Met Leu Val Ile Asp Asn Val Thr
18660 18665 18670
Arg Phe Asp Ser Gly Arg Tyr Asn Leu Thr Leu Glu Asn Asn Ser Gly
18675 18680 18685
Ser Lys Thr Ala Phe Val Asn Val Arg Val Leu Asp Ser Pro Ser Ala
18690 18695 18700
Pro Val Asn Leu Thr Ile Arg Glu Val Lys Lys Asp Ser Val Thr Leu
18705 18710 18715 18720
Ser Trp Glu Pro Pro Leu Ile Asp Gly Gly Ala Lys Ile Thr Asn Tyr
18725 18730 18735
Ile Val Glu Lys Arg Glu Thr Thr Arg Lys Ala Tyr Ala Thr Ile Thr
18740 18745 18750
Asn Asn Cys Thr Lys Thr Thr Phe Arg Ile Glu Asn Leu Gln Glu Gly
18755 18760 18765
Cys Ser Tyr Tyr Phe Arg Val Leu Ala Ser Asn Glu Tyr Gly Ile Gly
18770 18775 18780
Leu Pro Ala Glu Thr Thr Glu Pro Val Lys Val Ser Glu Pro Pro Leu
18785 18790 18795 18800
Pro Pro Gly Arg Val Thr Leu Val Asp Val Thr Arg Asn Thr Ala Thr
18805 18810 18815
Ile Lys Trp Glu Lys Pro Glu Ser Asp Gly Gly Ser Lys Ile Thr Gly
18820 18825 18830
Tyr Val Val Glu Met Gln Thr Lys Gly Ser Glu Lys Trp Ser Thr Cys
18835 18840 18845
Thr Gln Val Lys Thr Leu Glu Ala Thr Ile Ser Gly Leu Thr Ala Gly
18850 18855 18860
Glu Glu Tyr Val Phe Arg Val Ala Ala Val Asn Glu Lys Gly Arg Ser
18865 18870 18875 18880
Asp Pro Arg Gln Leu Gly Val Pro Val Ile Ala Arg Asp Ile Glu Ile
18885 18890 18895
Lys Pro Ser Val Glu Leu Pro Phe His Thr Phe Asn Val Lys Ala Arg
18900 18905 18910
Glu Gln Leu Lys Ile Asp Val Pro Phe Lys Gly Arg Pro Gln Ala Thr
18915 18920 18925
Val Asn Trp Arg Lys Asp Gly Gln Thr Leu Lys Glu Thr Thr Arg Val
18930 18935 18940
Asn Val Ser Ser Ser Lys Thr Val Thr Ser Leu Ser Ile Lys Glu Ala
18945 18950 18955 18960
Ser Lys Glu Asp Val Gly Thr Tyr Glu Leu Cys Val Ser Asn Ser Ala
18965 18970 18975
Gly Ser Ile Thr Val Pro Ile Thr Ile Ile Val Leu Asp Arg Pro Gly
18980 18985 18990
Pro Pro Gly Pro Ile Arg Ile Asp Glu Val Ser Cys Asp Ser Ile Thr
18995 19000 19005
Ile Ser Trp Asn Pro Pro Glu Tyr Asp Gly Gly Cys Gln Ile Ser Asn
19010 19015 19020
Tyr Ile Val Glu Lys Lys Glu Thr Thr Ser Thr Thr Trp His Ile Val
19025 19030 19035 19040
Ser Gln Ala Val Ala Arg Thr Ser Ile Lys Ile Val Arg Leu Thr Thr
19045 19050 19055
Gly Ser Glu Tyr Gln Phe Arg Val Cys Ala Glu Asn Arg Tyr Gly Lys
19060 19065 19070
Ser Ser Tyr Ser Glu Ser Ser Ala Val Val Ala Glu Tyr Pro Phe Ser
19075 19080 19085
Pro Pro Gly Pro Pro Gly Thr Pro Lys Val Val His Ala Thr Lys Ser
19090 19095 19100
Thr Met Leu Val Thr Trp Gln Val Pro Val Asn Asp Gly Gly Ser Arg
19105 19110 19115 19120
Val Ile Gly Tyr His Leu Glu Tyr Lys Glu Arg Ser Ser Ile Leu Trp
19125 19130 19135
Ser Lys Ala Asn Lys Ile Leu Ile Ala Asp Thr Gln Val Lys Val Ser
19140 19145 19150
Gly Leu Asp Glu Gly Leu Met Tyr Glu Tyr Arg Val Tyr Ala Glu Asn
19155 19160 19165
Ile Ala Gly Ile Gly Lys Cys Ser Lys Ser Cys Glu Pro Val Pro Ala
19170 19175 19180
Arg Asp Pro Cys Asp Pro Pro Gly Gln Pro Glu Val Thr Asn Ile Thr
19185 19190 19195 19200
Arg Lys Ser Val Ser Leu Lys Trp Ser Lys Pro His Tyr Asp Gly Gly
19205 19210 19215
Ala Lys Ile Thr Gly Tyr Ile Val Glu Arg Arg Glu Leu Pro Asp Gly
19220 19225 19230
Arg Trp Leu Lys Cys Asn Tyr Thr Asn Ile Gln Glu Thr Tyr Phe Glu
19235 19240 19245
Val Thr Glu Leu Thr Glu Asp Gln Arg Tyr Glu Phe Arg Val Phe Ala
19250 19255 19260
Arg Asn Ala Ala Asp Ser Val Ser Glu Pro Ser Glu Ser Thr Gly Pro
19265 19270 19275 19280
Ile Ile Val Lys Asp Asp Val Glu Pro Pro Arg Val Met Met Asp Val
19285 19290 19295
Lys Phe Arg Asp Val Ile Val Val Lys Ala Gly Glu Val Leu Lys Ile
19300 19305 19310
Asn Ala Asp Ile Ala Gly Arg Pro Leu Pro Val Ile Ser Trp Ala Lys
19315 19320 19325
Asp Gly Ile Glu Ile Glu Glu Arg Ala Arg Thr Glu Ile Ile Ser Thr
19330 19335 19340
Asp Asn His Thr Leu Leu Thr Val Lys Asp Cys Ile Arg Arg Asp Thr
19345 19350 19355 19360
Gly Gln Tyr Val Leu Thr Leu Lys Asn Val Ala Gly Thr Arg Ser Val
19365 19370 19375
Ala Val Asn Cys Lys Val Leu Asp Lys Pro Gly Pro Pro Ala Gly Pro
19380 19385 19390
Leu Glu Ile Asn Gly Leu Thr Ala Glu Lys Cys Ser Leu Ser Trp Gly
19395 19400 19405
Arg Pro Gln Glu Asp Gly Gly Ala Asp Ile Asp Tyr Tyr His Arg Lys
19410 19415 19420
Lys Arg Glu Thr Ser His Leu Ala Trp Thr Ile Cys Glu Gly Glu Leu
19425 19430 19435 19440
Gln Met Thr Ser Cys Lys Val Thr Lys Leu Leu Lys Gly Asn Glu Tyr
19445 19450 19455
Ile Phe Arg Val Thr Gly Val Asn Lys Tyr Gly Val Gly Glu Pro Leu
19460 19465 19470
Glu Ser Val Ala Ile Lys Ala Leu Asp Pro Phe Thr Val Pro Ser Pro
19475 19480 19485
Pro Thr Ser Leu Glu Ile Thr Ser Val Thr Lys Glu Ser Met Thr Leu
19490 19495 19500
Cys Trp Ser Arg Pro Glu Ser Asp Gly Gly Ser Glu Ile Ser Gly Tyr
19505 19510 19515 19520
Ile Ile Glu Arg Arg Glu Lys Asn Ser Leu Arg Trp Val Arg Val Asn
19525 19530 19535
Lys Lys Pro Val Tyr Asp Leu Arg Val Lys Ser Thr Gly Leu Arg Glu
19540 19545 19550
Gly Cys Glu Tyr Glu Tyr Arg Val Tyr Ala Glu Asn Ala Ala Gly Leu
19555 19560 19565
Ser Leu Pro Ser Glu Thr Ser Pro Leu Ile Arg Ala Glu Asp Pro Val
19570 19575 19580
Phe Leu Pro Ser Pro Pro Ser Lys Pro Lys Ile Val Asp Ser Gly Lys
19585 19590 19595 19600
Thr Thr Ile Thr Ile Ala Trp Val Lys Pro Leu Phe Asp Gly Gly Ala
19605 19610 19615
Pro Ile Thr Gly Tyr Thr Val Glu Tyr Lys Lys Ser Asp Asp Thr Asp
19620 19625 19630
Trp Lys Thr Ser Ile Gln Ser Leu Arg Gly Thr Glu Tyr Thr Ile Ser
19635 19640 19645
Gly Leu Thr Thr Gly Ala Glu Tyr Val Phe Arg Val Lys Ser Val Asn
19650 19655 19660
Lys Val Gly Ala Ser Asp Pro Ser Asp Ser Ser Asp Pro Gln Ile Ala
19665 19670 19675 19680
Lys Glu Arg Glu Glu Glu Pro Leu Phe Asp Ile Asp Ser Glu Met Arg
19685 19690 19695
Lys Thr Leu Ile Val Lys Ala Gly Ala Ser Phe Thr Met Thr Val Pro
19700 19705 19710
Phe Arg Gly Arg Pro Val Pro Asn Val Leu Trp Ser Lys Pro Asp Thr
19715 19720 19725
Asp Leu Arg Thr Arg Ala Tyr Val Asp Thr Thr Asp Ser Arg Thr Ser
19730 19735 19740
Leu Thr Ile Glu Asn Ala Asn Arg Asn Asp Ser Gly Lys Tyr Thr Leu
19745 19750 19755 19760
Thr Ile Gln Asn Val Leu Ser Ala Ala Ser Leu Thr Leu Val Val Lys
19765 19770 19775
Val Leu Asp Thr Pro Gly Pro Pro Thr Asn Ile Thr Val Gln Asp Val
19780 19785 19790
Thr Lys Glu Ser Ala Val Leu Ser Trp Asp Val Pro Glu Asn Asp Gly
19795 19800 19805
Gly Ala Pro Val Lys Asn Tyr His Ile Glu Lys Arg Glu Ala Ser Lys
19810 19815 19820
Lys Ala Trp Val Ser Val Thr Asn Asn Cys Asn Arg Leu Ser Tyr Lys
19825 19830 19835 19840
Val Thr Asn Leu Gln Glu Gly Ala Ile Tyr Tyr Phe Arg Val Ser Gly
19845 19850 19855
Glu Asn Glu Phe Gly Val Gly Ile Pro Ala Glu Thr Lys Glu Gly Val
19860 19865 19870
Lys Ile Thr Glu Lys Pro Ser Pro Pro Glu Lys Leu Gly Val Thr Ser
19875 19880 19885
Ile Ser Lys Asp Ser Val Ser Leu Thr Trp Leu Lys Pro Glu His Asp
19890 19895 19900
Gly Gly Ser Arg Ile Val His Tyr Val Val Glu Ala Leu Glu Lys Gly
19905 19910 19915 19920
Gln Lys Asn Trp Val Lys Cys Ala Val Ala Lys Ser Thr His His Val
19925 19930 19935
Val Ser Gly Leu Arg Glu Asn Ser Glu Tyr Phe Phe Arg Val Phe Ala
19940 19945 19950
Glu Asn Gln Ala Gly Leu Ser Asp Pro Arg Glu Leu Leu Leu Pro Val
19955 19960 19965
Leu Ile Lys Glu Gln Leu Glu Pro Pro Glu Ile Asp Met Lys Asn Phe
19970 19975 19980
Pro Ser His Thr Val Tyr Val Arg Ala Gly Ser Asn Leu Lys Val Asp
19985 19990 19995 20000
Ile Pro Ile Ser Gly Lys Pro Leu Pro Lys Val Thr Leu Ser Arg Asp
20005 20010 20015
Gly Val Pro Leu Lys Ala Thr Met Arg Phe Asn Thr Glu Ile Thr Ala
20020 20025 20030
Glu Asn Leu Thr Ile Asn Leu Lys Glu Ser Val Thr Ala Asp Ala Gly
20035 20040 20045
Arg Tyr Glu Ile Thr Ala Ala Asn Ser Ser Gly Thr Thr Lys Ala Phe
20050 20055 20060
Ile Asn Ile Val Val Leu Asp Arg Pro Gly Pro Pro Thr Gly Pro Val
20065 20070 20075 20080
Val Ile Ser Asp Ile Thr Glu Glu Ser Val Thr Leu Lys Trp Glu Pro
20085 20090 20095
Pro Lys Tyr Asp Gly Gly Ser Gln Val Thr Asn Tyr Ile Leu Leu Lys
20100 20105 20110
Arg Glu Thr Ser Thr Ala Val Trp Thr Glu Val Ser Ala Thr Val Ala
20115 20120 20125
Arg Thr Met Met Lys Val Met Lys Leu Thr Thr Gly Glu Glu Tyr Gln
20130 20135 20140
Phe Arg Ile Lys Ala Glu Asn Arg Phe Gly Ile Ser Asp His Ile Asp
20145 20150 20155 20160
Ser Ala Cys Val Thr Val Lys Leu Pro Tyr Thr Thr Pro Gly Pro Pro
20165 20170 20175
Ser Thr Pro Trp Val Thr Asn Val Thr Arg Glu Ser Ile Thr Val Gly
20180 20185 20190
Trp His Glu Pro Val Ser Asn Gly Gly Ser Ala Val Val Gly Tyr His
20195 20200 20205
Leu Glu Met Lys Asp Arg Asn Ser Ile Leu Trp Gln Lys Ala Asn Lys
20210 20215 20220
Leu Val Ile Arg Thr Thr His Phe Lys Val Thr Thr Ile Ser Ala Gly
20225 20230 20235 20240
Leu Ile Tyr Glu Phe Arg Val Tyr Ala Glu Asn Ala Ala Gly Val Gly
20245 20250 20255
Lys Pro Ser His Pro Ser Glu Pro Val Leu Ala Ile Asp Ala Cys Glu
20260 20265 20270
Pro Pro Arg Asn Val Arg Ile Thr Asp Ile Ser Lys Asn Ser Val Ser
20275 20280 20285
Leu Ser Trp Gln Gln Pro Ala Phe Asp Gly Gly Ser Lys Ile Thr Gly
20290 20295 20300
Tyr Ile Val Glu Arg Arg Asp Leu Pro Asp Gly Arg Trp Thr Lys Ala
20305 20310 20315 20320
Ser Phe Thr Asn Val Thr Glu Thr Gln Phe Thr Ile Ser Gly Leu Thr
20325 20330 20335
Gln Asn Ser Gln Tyr Glu Phe Arg Val Phe Ala Arg Asn Ala Val Gly
20340 20345 20350
Ser Ile Ser Asn Pro Ser Glu Val Val Gly Pro Ile Thr Cys Ile Asp
20355 20360 20365
Ser Tyr Gly Gly Pro Val Ile Asp Leu Pro Leu Glu Tyr Thr Glu Val
20370 20375 20380
Val Lys Tyr Arg Ala Gly Thr Ser Val Lys Leu Arg Ala Gly Ile Ser
20385 20390 20395 20400
Gly Lys Pro Ala Pro Thr Ile Glu Trp Tyr Lys Asp Asp Lys Glu Leu
20405 20410 20415
Gln Thr Asn Ala Leu Val Cys Val Glu Asn Thr Thr Asp Leu Ala Ser
20420 20425 20430
Ile Leu Ile Lys Asp Ala Asp Arg Leu Asn Ser Gly Cys Tyr Glu Leu
20435 20440 20445
Lys Leu Arg Asn Ala Met Ala Ser Ala Ser Ala Thr Ile Arg Val Gln
20450 20455 20460
Ile Leu Asp Lys Pro Gly Pro Pro Gly Gly Pro Ile Glu Phe Lys Thr
20465 20470 20475 20480
Val Thr Ala Glu Lys Ile Thr Leu Leu Trp Arg Pro Pro Ala Asp Asp
20485 20490 20495
Gly Gly Ala Lys Ile Thr His Tyr Ile Val Glu Lys Arg Glu Thr Ser
20500 20505 20510
Arg Val Val Trp Ser Met Val Ser Glu His Leu Glu Glu Cys Ile Ile
20515 20520 20525
Thr Thr Thr Lys Ile Ile Lys Gly Asn Glu Tyr Ile Phe Arg Val Arg
20530 20535 20540
Ala Val Asn Lys Tyr Gly Ile Gly Glu Pro Leu Glu Ser Asp Ser Val
20545 20550 20555 20560
Val Ala Lys Asn Ala Phe Val Thr Pro Gly Pro Pro Gly Ile Pro Glu
20565 20570 20575
Val Thr Lys Ile Thr Lys Asn Ser Met Thr Val Val Trp Ser Arg Pro
20580 20585 20590
Ile Ala Asp Gly Gly Ser Asp Ile Ser Gly Tyr Phe Leu Glu Lys Arg
20595 20600 20605
Asp Lys Lys Ser Leu Gly Trp Phe Lys Val Leu Lys Glu Thr Ile Arg
20610 20615 20620
Asp Thr Arg Gln Lys Val Thr Gly Leu Thr Glu Asn Ser Asp Tyr Gln
20625 20630 20635 20640
Tyr Arg Val Cys Ala Val Asn Ala Ala Gly Gln Gly Pro Phe Ser Glu
20645 20650 20655
Pro Ser Glu Phe Tyr Lys Ala Ala Asp Pro Ile Asp Pro Pro Gly Pro
20660 20665 20670
Pro Ala Lys Ile Arg Ile Ala Asp Ser Thr Lys Ser Ser Ile Thr Leu
20675 20680 20685
Gly Trp Ser Lys Pro Val Tyr Asp Gly Gly Ser Ala Val Thr Gly Tyr
20690 20695 20700
Val Val Glu Ile Arg Gln Gly Glu Glu Glu Glu Trp Thr Thr Val Ser
20705 20710 20715 20720
Thr Lys Gly Glu Val Arg Thr Thr Glu Tyr Val Val Ser Asn Leu Lys
20725 20730 20735
Pro Gly Val Asn Tyr Tyr Phe Arg Val Ser Ala Val Asn Cys Ala Gly
20740 20745 20750
Gln Gly Glu Pro Ile Glu Met Asn Glu Pro Val Gln Ala Lys Asp Ile
20755 20760 20765
Leu Glu Ala Pro Glu Ile Asp Leu Asp Val Ala Leu Arg Thr Ser Val
20770 20775 20780
Ile Ala Lys Ala Gly Glu Asp Val Gln Val Leu Ile Pro Phe Lys Gly
20785 20790 20795 20800
Arg Pro Pro Pro Thr Val Thr Trp Arg Lys Asp Glu Lys Asn Leu Gly
20805 20810 20815
Ser Asp Ala Arg Tyr Ser Ile Glu Asn Thr Asp Ser Ser Ser Leu Leu
20820 20825 20830
Thr Ile Pro Gln Val Thr Arg Asn Asp Thr Gly Lys Tyr Ile Leu Thr
20835 20840 20845
Ile Glu Asn Gly Val Gly Glu Pro Lys Ser Ser Thr Val Ser Val Lys
20850 20855 20860
Val Leu Asp Thr Pro Ala Ala Cys Gln Lys Leu Gln Val Lys His Val
20865 20870 20875 20880
Ser Arg Gly Thr Val Thr Leu Leu Trp Asp Pro Pro Leu Ile Asp Gly
20885 20890 20895
Gly Ser Pro Ile Ile Asn Tyr Val Ile Glu Lys Arg Asp Ala Thr Lys
20900 20905 20910
Arg Thr Trp Ser Val Val Ser His Lys Cys Ser Ser Thr Ser Phe Lys
20915 20920 20925
Leu Ile Asp Leu Ser Glu Lys Thr Pro Phe Phe Phe Arg Val Leu Ala
20930 20935 20940
Glu Asn Glu Ile Gly Ile Gly Glu Pro Cys Glu Thr Thr Glu Pro Val
20945 20950 20955 20960
Lys Ala Ala Glu Val Pro Ala Pro Ile Arg Asp Leu Ser Met Lys Asp
20965 20970 20975
Ser Thr Lys Thr Ser Val Ile Leu Ser Trp Thr Lys Pro Asp Phe Asp
20980 20985 20990
Gly Gly Ser Val Ile Thr Glu Tyr Val Val Glu Arg Lys Gly Lys Gly
20995 21000 21005
Glu Gln Thr Trp Ser His Ala Gly Ile Ser Lys Thr Cys Glu Ile Glu
21010 21015 21020
Val Ser Gln Leu Lys Glu Gln Ser Val Leu Glu Phe Arg Val Phe Ala
21025 21030 21035 21040
Lys Asn Glu Lys Gly Leu Ser Asp Pro Val Thr Ile Gly Pro Ile Thr
21045 21050 21055
Val Lys Glu Leu Ile Ile Thr Pro Glu Val Asp Leu Ser Asp Ile Pro
21060 21065 21070
Gly Ala Gln Val Thr Val Arg Ile Gly His Asn Val His Leu Glu Leu
21075 21080 21085
Pro Tyr Lys Gly Lys Pro Lys Pro Ser Ile Ser Trp Leu Lys Asp Gly
21090 21095 21100
Leu Pro Leu Lys Glu Ser Glu Phe Val Arg Phe Ser Lys Thr Glu Asn
21105 21110 21115 21120
Lys Ile Thr Leu Ser Ile Lys Asn Ala Lys Lys Glu His Gly Gly Lys
21125 21130 21135
Tyr Thr Val Ile Leu Asp Asn Ala Val Cys Arg Ile Ala Val Pro Ile
21140 21145 21150
Thr Val Ile Thr Leu Gly Pro Pro Ser Lys Pro Lys Gly Pro Ile Arg
21155 21160 21165
Phe Asp Glu Ile Lys Ala Asp Ser Val Ile Leu Ser Trp Asp Val Pro
21170 21175 21180
Glu Asp Asn Gly Gly Gly Glu Ile Thr Cys Tyr Ser Ile Glu Lys Arg
21185 21190 21195 21200
Glu Thr Ser Gln Thr Asn Trp Lys Met Val Cys Ser Ser Val Ala Arg
21205 21210 21215
Thr Thr Phe Lys Val Pro Asn Leu Val Lys Asp Ala Glu Tyr Gln Phe
21220 21225 21230
Arg Val Arg Ala Glu Asn Arg Tyr Gly Val Ser Gln Pro Leu Val Ser
21235 21240 21245
Ser Ile Ile Val Ala Lys His Gln Phe Arg Ile Pro Gly Pro Pro Gly
21250 21255 21260
Lys Pro Val Ile Tyr Asn Val Thr Ser Asp Gly Met Ser Leu Thr Trp
21265 21270 21275 21280
Asp Ala Pro Val Tyr Asp Gly Gly Ser Glu Val Thr Gly Phe His Val
21285 21290 21295
Glu Lys Lys Glu Arg Asn Ser Ile Leu Trp Gln Lys Val Asn Thr Ser
21300 21305 21310
Pro Ile Ser Gly Arg Glu Tyr Arg Ala Thr Gly Leu Val Glu Gly Leu
21315 21320 21325
Asp Tyr Gln Phe Arg Val Tyr Ala Glu Asn Ser Ala Gly Leu Ser Ser
21330 21335 21340
Pro Ser Asp Pro Ser Lys Phe Thr Leu Ala Val Ser Pro Val Asp Pro
21345 21350 21355 21360
Pro Gly Thr Pro Asp Tyr Ile Asp Val Thr Arg Glu Thr Ile Thr Leu
21365 21370 21375
Lys Trp Asn Pro Pro Leu Arg Asp Gly Gly Ser Lys Ile Val Gly Tyr
21380 21385 21390
Ser Ile Glu Lys Arg Gln Gly Asn Glu Arg Trp Val Arg Cys Asn Phe
21395 21400 21405
Thr Asp Val Ser Glu Cys Gln Tyr Thr Val Thr Gly Leu Ser Pro Gly
21410 21415 21420
Asp Arg Tyr Glu Phe Arg Ile Ile Ala Arg Asn Ala Val Gly Thr Ile
21425 21430 21435 21440
Ser Pro Pro Ser Gln Ser Ser Gly Ile Ile Met Thr Arg Asp Glu Asn
21445 21450 21455
Val Pro Pro Ile Val Glu Phe Gly Pro Glu Tyr Phe Asp Gly Leu Ile
21460 21465 21470
Ile Lys Ser Gly Glu Ser Leu Arg Ile Lys Ala Leu Val Gln Gly Arg
21475 21480 21485
Pro Val Pro Arg Val Thr Trp Phe Lys Asp Gly Val Glu Ile Glu Lys
21490 21495 21500
Arg Met Asn Met Glu Ile Thr Asn Val Leu Gly Ser Thr Ser Leu Phe
21505 21510 21515 21520
Val Arg Asp Ala Thr Arg Asp His Arg Gly Val Tyr Thr Val Glu Ala
21525 21530 21535
Lys Asn Ala Ser Gly Ser Ala Lys Ala Glu Ile Lys Val Lys Val Gln
21540 21545 21550
Asp Thr Pro Gly Lys Val Val Gly Pro Ile Arg Phe Thr Asn Ile Thr
21555 21560 21565
Gly Glu Lys Met Thr Leu Trp Trp Asp Ala Pro Leu Asn Asp Gly Cys
21570 21575 21580
Ala Pro Ile Thr His Tyr Ile Ile Glu Lys Arg Glu Thr Ser Arg Leu
21585 21590 21595 21600
Ala Trp Ala Leu Ile Glu Asp Lys Cys Glu Ala Gln Ser Tyr Thr Ala
21605 21610 21615
Ile Lys Leu Ile Asn Gly Asn Glu Tyr Gln Phe Arg Val Ser Ala Val
21620 21625 21630
Asn Lys Phe Gly Val Gly Arg Pro Leu Asp Ser Asp Pro Val Val Ala
21635 21640 21645
Gln Ile Gln Tyr Thr Val Pro Asp Ala Pro Gly Ile Pro Glu Pro Ser
21650 21655 21660
Asn Ile Thr Gly Asn Ser Ile Thr Leu Thr Trp Ala Arg Pro Glu Ser
21665 21670 21675 21680
Asp Gly Gly Ser Glu Ile Gln Gln Tyr Ile Leu Glu Arg Arg Glu Lys
21685 21690 21695
Lys Ser Thr Arg Trp Val Lys Val Ile Ser Lys Arg Pro Ile Ser Glu
21700 21705 21710
Thr Arg Phe Lys Val Thr Gly Leu Thr Glu Gly Asn Glu Tyr Glu Phe
21715 21720 21725
His Val Met Ala Glu Asn Ala Ala Gly Val Gly Pro Ala Ser Gly Ile
21730 21735 21740
Ser Arg Leu Ile Lys Cys Arg Glu Pro Val Asn Pro Pro Gly Pro Pro
21745 21750 21755 21760
Thr Val Val Lys Val Thr Asp Thr Ser Lys Thr Thr Val Ser Leu Glu
21765 21770 21775
Trp Ser Lys Pro Val Phe Asp Gly Gly Met Glu Ile Ile Gly Tyr Ile
21780 21785 21790
Ile Glu Met Cys Lys Thr Asp Leu Gly Asp Trp His Lys Val Asn Ala
21795 21800 21805
Glu Ala Cys Val Lys Thr Arg Tyr Thr Val Thr Asp Leu Gln Ala Gly
21810 21815 21820
Glu Glu Tyr Lys Phe Arg Val Ser Ala Ile Asn Gly Ala Gly Lys Gly
21825 21830 21835 21840
Asp Ser Cys Glu Val Thr Gly Thr Ile Lys Ala Val Asp Arg Leu Thr
21845 21850 21855
Ala Pro Glu Leu Asp Ile Asp Ala Asn Phe Lys Gln Thr His Val Val
21860 21865 21870
Arg Ala Gly Ala Ser Ile Arg Leu Phe Ile Ala Tyr Gln Gly Arg Pro
21875 21880 21885
Thr Pro Thr Ala Val Trp Ser Lys Pro Asp Ser Asn Leu Ser Leu Arg
21890 21895 21900
Ala Asp Ile His Thr Thr Asp Ser Phe Ser Thr Leu Thr Val Glu Asn
21905 21910 21915 21920
Cys Asn Arg Asn Asp Ala Gly Lys Tyr Thr Leu Thr Val Glu Asn Asn
21925 21930 21935
Ser Gly Ser Lys Ser Ile Thr Phe Thr Val Lys Val Leu Asp Thr Pro
21940 21945 21950
Gly Pro Pro Gly Pro Ile Thr Phe Lys Asp Val Thr Arg Gly Ser Ala
21955 21960 21965
Thr Leu Met Trp Asp Ala Pro Leu Leu Asp Gly Gly Ala Arg Ile His
21970 21975 21980
His Tyr Val Val Glu Lys Arg Glu Ala Ser Arg Arg Ser Trp Gln Val
21985 21990 21995 22000
Ile Ser Glu Lys Cys Thr Arg Gln Ile Phe Lys Val Asn Asp Leu Ala
22005 22010 22015
Glu Gly Val Pro Tyr Tyr Phe Arg Val Ser Ala Val Asn Glu Tyr Gly
22020 22025 22030
Val Gly Glu Pro Tyr Glu Met Pro Glu Pro Ile Val Ala Thr Glu Gln
22035 22040 22045
Pro Ala Pro Pro Arg Arg Leu Asp Val Val Asp Thr Ser Lys Ser Ser
22050 22055 22060
Ala Val Leu Ala Trp Leu Lys Pro Asp His Asp Gly Gly Ser Arg Ile
22065 22070 22075 22080
Thr Gly Tyr Leu Leu Glu Met Arg Gln Lys Gly Ser Asp Leu Trp Val
22085 22090 22095
Glu Ala Gly His Thr Lys Gln Leu Thr Phe Thr Val Glu Arg Leu Val
22100 22105 22110
Glu Lys Thr Glu Tyr Glu Phe Arg Val Lys Ala Lys Asn Asp Ala Gly
22115 22120 22125
Tyr Ser Glu Pro Arg Glu Ala Phe Ser Ser Val Ile Ile Lys Glu Pro
22130 22135 22140
Gln Ile Glu Pro Thr Ala Asp Leu Thr Gly Ile Thr Asn Gln Leu Ile
22145 22150 22155 22160
Thr Cys Lys Ala Gly Ser Pro Phe Thr Ile Asp Val Pro Ile Ser Gly
22165 22170 22175
Arg Pro Ala Pro Lys Val Thr Trp Lys Leu Glu Glu Met Arg Leu Lys
22180 22185 22190
Glu Thr Asp Arg Val Ser Ile Thr Thr Thr Lys Asp Arg Thr Thr Leu
22195 22200 22205
Thr Val Lys Asp Ser Met Arg Gly Asp Ser Gly Arg Tyr Phe Leu Thr
22210 22215 22220
Leu Glu Asn Thr Ala Gly Val Lys Thr Phe Ser Val Thr Val Val Val
22225 22230 22235 22240
Ile Gly Arg Pro Gly Pro Val Thr Gly Pro Ile Glu Val Ser Ser Val
22245 22250 22255
Ser Ala Glu Ser Cys Val Leu Ser Trp Gly Glu Pro Lys Asp Gly Gly
22260 22265 22270
Gly Thr Glu Ile Thr Asn Tyr Ile Val Glu Lys Arg Glu Ser Gly Thr
22275 22280 22285
Thr Ala Trp Gln Leu Val Asn Ser Ser Val Lys Arg Thr Gln Ile Lys
22290 22295 22300
Val Thr His Leu Thr Lys Tyr Met Glu Tyr Ser Phe Arg Val Ser Ser
22305 22310 22315 22320
Glu Asn Arg Phe Gly Val Ser Lys Pro Leu Glu Ser Ala Pro Ile Ile
22325 22330 22335
Ala Glu His Pro Phe Val Pro Pro Ser Ala Pro Thr Arg Pro Glu Val
22340 22345 22350
Tyr His Val Ser Ala Asn Ala Met Ser Ile Arg Trp Glu Glu Pro Tyr
22355 22360 22365
His Asp Gly Gly Ser Lys Ile Ile Gly Tyr Trp Val Glu Lys Lys Glu
22370 22375 22380
Arg Asn Thr Ile Leu Trp Val Lys Glu Asn Lys Val Pro Cys Leu Glu
22385 22390 22395 22400
Cys Asn Tyr Lys Val Thr Gly Leu Val Glu Gly Leu Glu Tyr Gln Phe
22405 22410 22415
Arg Thr Tyr Ala Leu Asn Ala Ala Gly Val Ser Lys Ala Ser Glu Ala
22420 22425 22430
Ser Arg Pro Ile Met Ala Gln Asn Pro Val Asp Ala Pro Gly Arg Pro
22435 22440 22445
Glu Val Thr Asp Val Thr Arg Ser Thr Val Ser Leu Ile Trp Ser Ala
22450 22455 22460
Pro Ala Tyr Asp Gly Gly Ser Lys Val Val Gly Tyr Ile Ile Glu Arg
22465 22470 22475 22480
Lys Pro Val Ser Glu Val Gly Asp Gly Arg Trp Leu Lys Cys Asn Tyr
22485 22490 22495
Thr Ile Val Ser Asp Asn Phe Phe Thr Val Thr Ala Leu Ser Glu Gly
22500 22505 22510
Asp Thr Tyr Glu Phe Arg Val Leu Ala Lys Asn Ala Ala Gly Val Ile
22515 22520 22525
Ser Lys Gly Ser Glu Ser Thr Gly Pro Val Thr Cys Arg Asp Glu Tyr
22530 22535 22540
Ala Pro Pro Lys Ala Glu Leu Asp Ala Arg Leu His Gly Asp Leu Val
22545 22550 22555 22560
Thr Ile Arg Ala Gly Ser Asp Leu Val Leu Asp Ala Ala Val Gly Gly
22565 22570 22575
Lys Pro Glu Pro Lys Ile Ile Trp Thr Lys Gly Asp Lys Glu Leu Asp
22580 22585 22590
Leu Cys Glu Lys Val Ser Leu Gln Tyr Thr Gly Lys Arg Ala Thr Ala
22595 22600 22605
Val Ile Lys Phe Cys Asp Arg Ser Asp Ser Gly Lys Tyr Thr Leu Thr
22610 22615 22620
Val Lys Asn Ala Ser Gly Thr Lys Ala Val Ser Val Met Val Lys Val
22625 22630 22635 22640
Leu Asp Ser Pro Gly Pro Cys Gly Lys Leu Thr Val Ser Arg Val Thr
22645 22650 22655
Gln Glu Lys Cys Thr Leu Ala Trp Ser Leu Pro Gln Glu Asp Gly Gly
22660 22665 22670
Ala Glu Ile Thr His Tyr Ile Val Glu Arg Arg Glu Thr Ser Arg Leu
22675 22680 22685
Asn Trp Val Ile Val Glu Gly Glu Cys Pro Thr Leu Ser Tyr Val Val
22690 22695 22700
Thr Arg Leu Ile Lys Asn Asn Glu Tyr Ile Phe Arg Val Arg Ala Val
22705 22710 22715 22720
Asn Lys Tyr Gly Pro Gly Val Pro Val Glu Ser Glu Pro Ile Val Ala
22725 22730 22735
Arg Asn Ser Phe Thr Ile Pro Ser Pro Pro Gly Ile Pro Glu Glu Val
22740 22745 22750
Gly Thr Gly Lys Glu His Ile Ile Ile Gln Trp Thr Lys Pro Glu Ser
22755 22760 22765
Asp Gly Gly Asn Glu Ile Ser Asn Tyr Leu Val Asp Lys Arg Glu Lys
22770 22775 22780
Glu Ser Leu Arg Trp Thr Arg Val Asn Lys Asp Tyr Val Val Tyr Asp
22785 22790 22795 22800
Thr Arg Leu Lys Val Thr Ser Leu Met Glu Gly Cys Asp Tyr Gln Phe
22805 22810 22815
Arg Val Thr Ala Val Asn Ala Ala Gly Asn Ser Glu Pro Ser Glu Arg
22820 22825 22830
Ser Asn Phe Ile Ser Cys Arg Glu Pro Ser Tyr Thr Pro Gly Pro Pro
22835 22840 22845
Ser Ala Pro Arg Val Val Asp Thr Thr Lys His Ser Ile Ser Leu Ala
22850 22855 22860
Trp Thr Lys Pro Met Tyr Asp Gly Gly Thr Asp Ile Val Gly Tyr Val
22865 22870 22875 22880
Leu Glu Met Gln Glu Lys Asp Thr Asp Gln Trp Tyr Arg Val His Thr
22885 22890 22895
Asn Ala Thr Ile Arg Asn Thr Glu Phe Thr Val Pro Asp Leu Lys Met
22900 22905 22910
Gly Gln Lys Tyr Ser Phe Arg Val Ala Ala Val Asn Val Lys Gly Met
22915 22920 22925
Ser Glu Tyr Ser Glu Ser Ile Ala Glu Ile Glu Pro Val Glu Arg Ile
22930 22935 22940
Glu Ile Pro Asp Leu Glu Leu Ala Asp Asp Leu Lys Lys Thr Val Thr
22945 22950 22955 22960
Ile Arg Ala Gly Ala Ser Leu Arg Leu Met Val Ser Val Ser Gly Arg
22965 22970 22975
Pro Pro Pro Val Ile Thr Trp Ser Lys Gln Gly Ile Asp Leu Ala Ser
22980 22985 22990
Arg Ala Ile Ile Asp Thr Thr Glu Ser Tyr Ser Leu Leu Ile Val Asp
22995 23000 23005
Lys Val Asn Arg Tyr Asp Ala Gly Lys Tyr Thr Ile Glu Ala Glu Asn
23010 23015 23020
Gln Ser Gly Lys Lys Ser Ala Thr Val Leu Val Lys Val Tyr Asp Thr
23025 23030 23035 23040
Pro Gly Pro Cys Pro Ser Val Lys Val Lys Glu Val Ser Arg Asp Ser
23045 23050 23055
Val Thr Ile Thr Trp Glu Ile Pro Thr Ile Asp Gly Gly Ala Pro Ile
23060 23065 23070
Asn Asn Tyr Ile Val Glu Lys Arg Glu Ala Ala Met Arg Ala Phe Lys
23075 23080 23085
Thr Val Thr Thr Lys Cys Ser Lys Thr Leu Tyr Arg Ile Ser Gly Leu
23090 23095 23100
Val Glu Gly Thr Met His Tyr Phe Arg Val Leu Pro Glu Asn Ile Tyr
23105 23110 23115 23120
Gly Ile Gly Glu Pro Cys Glu Thr Ser Asp Ala Val Leu Val Ser Glu
23125 23130 23135
Val Pro Leu Val Pro Ala Lys Leu Glu Val Val Asp Val Thr Lys Ser
23140 23145 23150
Thr Val Thr Leu Ala Trp Glu Lys Pro Leu Tyr Asp Gly Gly Ser Arg
23155 23160 23165
Leu Thr Gly Tyr Val Leu Glu Ala Cys Lys Ala Gly Thr Glu Arg Trp
23170 23175 23180
Met Lys Val Val Thr Leu Lys Pro Thr Val Leu Glu His Thr Val Thr
23185 23190 23195 23200
Ser Leu Asn Glu Gly Glu Gln Tyr Leu Phe Arg Ile Arg Ala Gln Asn
23205 23210 23215
Glu Lys Gly Val Ser Glu Pro Arg Glu Thr Val Thr Ala Val Thr Val
23220 23225 23230
Gln Asp Leu Arg Val Leu Pro Thr Ile Asp Leu Ser Thr Met Pro Gln
23235 23240 23245
Lys Thr Ile His Val Pro Ala Gly Arg Pro Val Glu Leu Val Ile Pro
23250 23255 23260
Ile Ala Gly Arg Pro Pro Pro Ala Ala Ser Trp Phe Phe Ala Gly Ser
23265 23270 23275 23280
Lys Leu Arg Glu Ser Glu Arg Val Thr Val Glu Thr His Thr Lys Val
23285 23290 23295
Ala Lys Leu Thr Ile Arg Glu Thr Thr Ile Arg Asp Thr Gly Glu Tyr
23300 23305 23310
Thr Leu Glu Leu Lys Asn Val Thr Gly Thr Thr Ser Glu Thr Ile Lys
23315 23320 23325
Val Ile Ile Leu Asp Lys Pro Gly Pro Pro Thr Gly Pro Ile Lys Ile
23330 23335 23340
Asp Glu Ile Asp Ala Thr Ser Ile Thr Ile Ser Trp Glu Pro Pro Glu
23345 23350 23355 23360
Leu Asp Gly Gly Ala Pro Leu Ser Gly Tyr Val Val Glu Gln Arg Asp
23365 23370 23375
Ala His Arg Pro Gly Trp Leu Pro Val Ser Glu Ser Val Thr Arg Ser
23380 23385 23390
Thr Phe Lys Phe Thr Arg Leu Thr Glu Gly Asn Glu Tyr Val Phe Arg
23395 23400 23405
Val Ala Ala Thr Asn Arg Phe Gly Ile Gly Ser Tyr Leu Gln Ser Glu
23410 23415 23420
Val Ile Glu Cys Arg Ser Ser Ile Arg Ile Pro Gly Pro Pro Glu Thr
23425 23430 23435 23440
Leu Gln Ile Phe Asp Val Ser Arg Asp Gly Met Thr Leu Thr Trp Tyr
23445 23450 23455
Pro Pro Glu Asp Asp Gly Gly Ser Gln Val Thr Gly Tyr Ile Val Glu
23460 23465 23470
Arg Lys Glu Val Arg Ala Asp Arg Trp Val Arg Val Asn Lys Val Pro
23475 23480 23485
Val Thr Met Thr Arg Tyr Arg Ser Thr Gly Leu Thr Glu Gly Leu Glu
23490 23495 23500
Tyr Glu His Arg Val Thr Ala Ile Asn Ala Arg Gly Ser Gly Lys Pro
23505 23510 23515 23520
Ser Arg Pro Ser Lys Pro Ile Val Ala Met Asp Pro Ile Ala Pro Pro
23525 23530 23535
Gly Lys Pro Gln Asn Pro Arg Val Thr Asp Thr Thr Arg Thr Ser Val
23540 23545 23550
Ser Leu Ala Trp Ser Val Pro Glu Asp Glu Gly Gly Ser Lys Val Thr
23555 23560 23565
Gly Tyr Leu Ile Glu Met Gln Lys Val Asp Gln His Glu Trp Thr Lys
23570 23575 23580
Cys Asn Thr Thr Pro Thr Lys Ile Arg Glu Tyr Thr Leu Thr His Leu
23585 23590 23595 23600
Pro Gln Gly Ala Glu Tyr Arg Phe Arg Val Leu Ala Cys Asn Ala Gly
23605 23610 23615
Gly Pro Gly Glu Pro Ala Glu Val Pro Gly Thr Val Lys Val Thr Glu
23620 23625 23630
Met Leu Glu Tyr Pro Asp Tyr Glu Leu Asp Glu Arg Tyr Gln Glu Gly
23635 23640 23645
Ile Phe Val Arg Gln Gly Gly Val Ile Arg Leu Thr Ile Pro Ile Lys
23650 23655 23660
Gly Lys Pro Phe Pro Ile Cys Lys Trp Thr Lys Glu Gly Gln Asp Ile
23665 23670 23675 23680
Ser Lys Arg Ala Met Ile Ala Thr Ser Glu Thr His Thr Glu Leu Val
23685 23690 23695
Ile Lys Glu Ala Asp Arg Gly Asp Ser Gly Thr Tyr Asp Leu Val Leu
23700 23705 23710
Glu Asn Lys Cys Gly Lys Lys Ala Val Tyr Ile Lys Val Arg Val Ile
23715 23720 23725
Gly Ser Pro Asn Ser Pro Glu Gly Pro Leu Glu Tyr Asp Asp Ile Gln
23730 23735 23740
Val Arg Ser Val Arg Val Ser Trp Arg Pro Pro Ala Asp Asp Gly Gly
23745 23750 23755 23760
Ala Asp Ile Leu Gly Tyr Ile Leu Glu Arg Arg Glu Val Pro Lys Ala
23765 23770 23775
Ala Trp Tyr Thr Ile Asp Ser Arg Val Arg Gly Thr Ser Leu Val Val
23780 23785 23790
Lys Gly Leu Lys Glu Asn Val Glu Tyr His Phe Arg Val Ser Ala Glu
23795 23800 23805
Asn Gln Phe Gly Ile Ser Lys Pro Leu Lys Ser Glu Glu Pro Val Thr
23810 23815 23820
Pro Lys Thr Pro Leu Asn Pro Pro Glu Pro Pro Ser Asn Pro Pro Glu
23825 23830 23835 23840
Val Leu Asp Val Thr Lys Ser Ser Val Ser Leu Ser Trp Ser Arg Pro
23845 23850 23855
Lys Asp Asp Gly Gly Ser Arg Val Thr Gly Tyr Tyr Ile Glu Arg Lys
23860 23865 23870
Glu Thr Ser Thr Asp Lys Val Val Arg His Asn Lys Thr Gln Ile Thr
23875 23880 23885
Thr Thr Met Tyr Thr Val Thr Gly Leu Val Pro Asp Ala Glu Tyr Gln
23890 23895 23900
Phe Arg Ile Ile Ala Gln Asn Asp Val Gly Leu Ser Glu Thr Ser Pro
23905 23910 23915 23920
Ala Ser Glu Pro Val Val Cys Lys Asp Pro Phe Asp Lys Pro Ser Gln
23925 23930 23935
Pro Gly Glu Leu Glu Ile Leu Ser Ile Ser Lys Asp Ser Val Thr Leu
23940 23945 23950
Gln Trp Glu Lys Pro Glu Cys Asp Gly Gly Lys Glu Ile Leu Gly Tyr
23955 23960 23965
Trp Val Glu Tyr Arg Gln Ser Gly Asp Ser Ala Trp Lys Lys Ser Asn
23970 23975 23980
Lys Glu Arg Ile Lys Asp Lys Gln Phe Thr Ile Gly Gly Leu Leu Glu
23985 23990 23995 24000
Ala Thr Glu Tyr Glu Phe Arg Val Phe Ala Glu Asn Glu Thr Gly Leu
24005 24010 24015
Ser Arg Pro Arg Arg Thr Ala Met Ser Ile Lys Thr Lys Leu Thr Ser
24020 24025 24030
Gly Glu Ala Pro Gly Ile Arg Lys Glu Met Lys Asp Val Thr Thr Lys
24035 24040 24045
Leu Gly Glu Ala Ala Gln Leu Ser Cys Gln Ile Val Gly Arg Pro Leu
24050 24055 24060
Pro Asp Ile Lys Trp Tyr Arg Phe Gly Lys Glu Leu Ile Gln Ser Arg
24065 24070 24075 24080
Lys Tyr Lys Met Ser Ser Asp Gly Arg Thr His Thr Leu Thr Val Met
24085 24090 24095
Thr Glu Glu Gln Glu Asp Glu Gly Val Tyr Thr Cys Ile Ala Thr Asn
24100 24105 24110
Glu Val Gly Glu Val Glu Thr Ser Ser Lys Leu Leu Leu Gln Ala Thr
24115 24120 24125
Pro Gln Phe His Pro Gly Tyr Pro Leu Lys Glu Lys Tyr Tyr Gly Ala
24130 24135 24140
Val Gly Ser Thr Leu Arg Leu His Val Met Tyr Ile Gly Arg Pro Val
24145 24150 24155 24160
Pro Ala Met Thr Trp Phe His Gly Gln Lys Leu Leu Gln Asn Ser Glu
24165 24170 24175
Asn Ile Thr Ile Glu Asn Thr Glu His Tyr Thr His Leu Val Met Lys
24180 24185 24190
Asn Val Gln Arg Lys Thr His Ala Gly Lys Tyr Lys Val Gln Leu Ser
24195 24200 24205
Asn Val Phe Gly Thr Val Asp Ala Ile Leu Asp Val Glu Ile Gln Asp
24210 24215 24220
Lys Pro Asp Lys Pro Thr Gly Pro Ile Val Ile Glu Ala Leu Leu Lys
24225 24230 24235 24240
Asn Ser Ala Val Ile Ser Trp Lys Pro Pro Ala Asp Asp Gly Gly Ser
24245 24250 24255
Trp Ile Thr Asn Tyr Val Val Glu Lys Cys Glu Ala Lys Glu Gly Ala
24260 24265 24270
Glu Trp Gln Leu Val Ser Ser Ala Ile Ser Val Thr Thr Cys Arg Ile
24275 24280 24285
Val Asn Leu Thr Glu Asn Ala Gly Tyr Tyr Phe Arg Val Ser Ala Gln
24290 24295 24300
Asn Thr Phe Gly Ile Ser Asp Pro Leu Glu Val Ser Ser Val Val Ile
24305 24310 24315 24320
Ile Lys Ser Pro Phe Glu Lys Pro Gly Ala Pro Gly Lys Pro Thr Ile
24325 24330 24335
Thr Ala Val Thr Lys Asp Ser Cys Val Val Ala Trp Lys Pro Pro Ala
24340 24345 24350
Ser Asp Gly Gly Ala Lys Ile Arg Asn Tyr Tyr Leu Glu Lys Arg Glu
24355 24360 24365
Lys Lys Gln Asn Lys Trp Ile Ser Val Thr Thr Glu Glu Ile Arg Glu
24370 24375 24380
Thr Val Phe Ser Val Lys Asn Leu Ile Glu Gly Leu Glu Tyr Glu Phe
24385 24390 24395 24400
Arg Val Lys Cys Glu Asn Leu Gly Gly Glu Ser Glu Trp Ser Glu Ile
24405 24410 24415
Ser Glu Pro Ile Thr Pro Lys Ser Asp Val Pro Ile Gln Ala Pro His
24420 24425 24430
Phe Lys Glu Glu Leu Arg Asn Leu Asn Val Arg Tyr Gln Ser Asn Ala
24435 24440 24445
Thr Leu Val Cys Lys Val Thr Gly His Pro Lys Pro Ile Val Lys Trp
24450 24455 24460
Tyr Arg Gln Gly Lys Glu Ile Ile Ala Asp Gly Leu Lys Tyr Arg Ile
24465 24470 24475 24480
Gln Glu Phe Lys Gly Gly Tyr His Gln Leu Ile Ile Ala Ser Val Thr
24485 24490 24495
Asp Asp Asp Ala Thr Val Tyr Gln Val Arg Ala Thr Asn Gln Gly Gly
24500 24505 24510
Ser Val Ser Gly Thr Ala Ser Leu Glu Val Glu Val Pro Ala Lys Ile
24515 24520 24525
His Leu Pro Lys Thr Leu Glu Gly Met Gly Ala Val His Ala Leu Arg
24530 24535 24540
Gly Glu Val Val Ser Ile Lys Ile Pro Phe Ser Gly Lys Pro Asp Pro
24545 24550 24555 24560
Val Ile Thr Trp Gln Lys Gly Gln Asp Leu Ile Asp Asn Asn Gly His
24565 24570 24575
Tyr Gln Val Ile Val Thr Arg Ser Phe Thr Ser Leu Val Phe Pro Asn
24580 24585 24590
Gly Val Glu Arg Lys Asp Ala Gly Phe Tyr Val Val Cys Ala Lys Asn
24595 24600 24605
Arg Phe Gly Ile Asp Gln Lys Thr Val Glu Leu Asp Val Ala Asp Val
24610 24615 24620
Pro Asp Pro Pro Arg Gly Val Lys Val Ser Asp Ala Ser Arg Asp Ser
24625 24630 24635 24640
Val Asn Leu Thr Trp Thr Glu Pro Ala Ser Asp Gly Gly Ser Lys Ile
24645 24650 24655
Thr Asn Tyr Ile Val Glu Lys Cys Ala Thr Thr Ala Glu Arg Trp Leu
24660 24665 24670
Arg Val Gly Gln Ala Arg Glu Thr Arg Tyr Thr Val Ile Asn Leu Phe
24675 24680 24685
Gly Lys Thr Ser Tyr Gln Phe Arg Val Ile Ala Glu Asn Lys Phe Gly
24690 24695 24700
Leu Ser Lys Pro Ser Glu Pro Ser Glu Pro Thr Ile Thr Lys Glu Asp
24705 24710 24715 24720
Lys Thr Arg Ala Met Asn Tyr Asp Glu Glu Val Asp Glu Thr Arg Glu
24725 24730 24735
Val Ser Met Thr Lys Ala Ser His Ser Ser Thr Lys Glu Leu Tyr Glu
24740 24745 24750
Lys Tyr Met Ile Ala Glu Asp Leu Gly Arg Gly Glu Phe Gly Ile Val
24755 24760 24765
His Arg Cys Val Glu Thr Ser Ser Lys Lys Thr Tyr Met Ala Lys Phe
24770 24775 24780
Val Lys Val Lys Gly Thr Asp Gln Val Leu Val Lys Lys Glu Ile Ser
24785 24790 24795 24800
Ile Leu Asn Ile Ala Arg His Arg Asn Ile Leu His Leu His Glu Ser
24805 24810 24815
Phe Glu Ser Met Glu Glu Leu Val Met Ile Phe Glu Phe Ile Ser Gly
24820 24825 24830
Leu Asp Ile Phe Glu Arg Ile Asn Thr Ser Ala Phe Glu Leu Asn Glu
24835 24840 24845
Arg Glu Ile Val Ser Tyr Val His Gln Val Cys Glu Ala Leu Gln Phe
24850 24855 24860
Leu His Ser His Asn Ile Gly His Phe Asp Ile Arg Pro Glu Asn Ile
24865 24870 24875 24880
Ile Tyr Gln Thr Arg Arg Ser Ser Thr Ile Lys Ile Ile Glu Phe Gly
24885 24890 24895
Gln Ala Arg Gln Leu Lys Pro Gly Asp Asn Phe Arg Leu Leu Phe Thr
24900 24905 24910
Ala Pro Glu Tyr Tyr Ala Pro Glu Val His Gln His Asp Val Val Ser
24915 24920 24925
Thr Ala Thr Asp Met Trp Ser Leu Gly Thr Leu Val Tyr Val Leu Leu
24930 24935 24940
Ser Gly Ile Asn Pro Phe Leu Ala Glu Thr Asn Gln Gln Ile Ile Glu
24945 24950 24955 24960
Asn Ile Met Asn Ala Glu Tyr Thr Phe Asp Glu Glu Ala Phe Lys Glu
24965 24970 24975
Ile Ser Ile Glu Ala Met Asp Phe Val Asp Arg Leu Leu Val Lys Glu
24980 24985 24990
Arg Lys Ser Arg Met Thr Ala Ser Glu Ala Leu Gln His Pro Trp Leu
24995 25000 25005
Lys Gln Lys Ile Glu Arg Val Ser Thr Lys Val Ile Arg Thr Leu Lys
25010 25015 25020
His Arg Arg Tyr Tyr His Thr Leu Ile Lys Lys Asp Leu Asn Met Val
25025 25030 25035 25040
Val Ser Ala Ala Arg Ile Ser Cys Gly Gly Ala Ile Arg Ser Gln Lys
25045 25050 25055
Gly Val Ser Val Ala Lys Val Lys Val Ala Ser Ile Glu Ile Gly Pro
25060 25065 25070
Val Ser Gly Gln Ile Met His Ala Val Gly Glu Glu Gly Gly His Val
25075 25080 25085
Lys Tyr Val Cys Lys Ile Glu Asn Tyr Asp Gln Ser Thr Gln Val Thr
25090 25095 25100
Trp Tyr Phe Gly Val Arg Gln Leu Glu Asn Ser Glu Lys Tyr Glu Ile
25105 25110 25115 25120
Thr Tyr Glu Asp Gly Val Ala Ile Leu Tyr Val Lys Asp Ile Thr Lys
25125 25130 25135
Leu Asp Asp Gly Thr Tyr Arg Cys Lys Val Val Asn Asp Tyr Gly Glu
25140 25145 25150
Asp Ser Ser Tyr Ala Glu Leu Phe Val Lys Gly Val Arg Glu Val Tyr
25155 25160 25165
Asp Tyr Tyr Cys Arg Arg Thr Met Lys Lys Ile Lys Arg Arg Thr Asp
25170 25175 25180
Thr Met Arg Leu Leu Glu Arg Pro Pro Glu Phe Thr Leu Pro Leu Tyr
25185 25190 25195 25200
Asn Lys Thr Ala Tyr Val Gly Glu Asn Val Arg Phe Gly Val Thr Ile
25205 25210 25215
Thr Val His Pro Glu Pro His Val Thr Trp Tyr Lys Ser Gly Gln Lys
25220 25225 25230
Ile Lys Pro Gly Asp Asn Asp Lys Lys Tyr Thr Phe Glu Ser Asp Lys
25235 25240 25245
Gly Leu Tyr Gln Leu Thr Ile Asn Ser Val Thr Thr Asp Asp Asp Ala
25250 25255 25260
Glu Tyr Thr Val Val Ala Arg Asn Lys Tyr Gly Glu Asp Ser Cys Lys
25265 25270 25275 25280
Ala Lys Leu Thr Val Thr Leu His Pro Pro Pro Thr Asp Ser Thr Leu
25285 25290 25295
Arg Pro Met Phe Lys Arg Leu Leu Ala Asn Ala Glu Cys Gln Glu Gly
25300 25305 25310
Gln Ser Val Cys Phe Glu Ile Arg Val Ser Gly Ile Pro Pro Pro Thr
25315 25320 25325
Leu Lys Trp Glu Lys Asp Gly Gln Pro Leu Ser Leu Gly Pro Asn Ile
25330 25335 25340
Glu Ile Ile His Glu Gly Leu Asp Tyr Tyr Ala Leu His Ile Arg Asp
25345 25350 25355 25360
Thr Leu Pro Glu Asp Thr Gly Tyr Tyr Arg Val Thr Ala Thr Asn Thr
25365 25370 25375
Ala Gly Ser Thr Ser Cys Gln Ala His Leu Gln Val Glu Arg Leu Arg
25380 25385 25390
Tyr Lys Lys Gln Glu Phe Lys Ser Lys Glu Glu His Glu Arg His Val
25395 25400 25405
Gln Lys Gln Ile Asp Lys Thr Leu Arg Met Ala Glu Ile Leu Ser Gly
25410 25415 25420
Thr Glu Ser Val Pro Leu Thr Gln Val Ala Lys Glu Ala Leu Arg Glu
25425 25430 25435 25440
Ala Ala Val Leu Tyr Lys Pro Ala Val Ser Thr Lys Thr Val Lys Gly
25445 25450 25455
Glu Phe Arg Leu Glu Ile Glu Glu Lys Lys Glu Glu Arg Lys Leu Arg
25460 25465 25470
Met Pro Tyr Asp Val Pro Glu Pro Arg Lys Tyr Lys Gln Thr Thr Ile
25475 25480 25485
Glu Glu Asp Gln Arg Ile Lys Gln Phe Val Pro Met Ser Asp Met Lys
25490 25495 25500
Trp Tyr Lys Lys Ile Arg Asp Gln Tyr Glu Met Pro Gly Lys Leu Asp
25505 25510 25515 25520
Arg Val Val Gln Lys Arg Pro Lys Arg Ile Arg Leu Ser Arg Trp Glu
25525 25530 25535
Gln Phe Tyr Val Met Pro Leu Pro Arg Ile Thr Asp Gln Tyr Arg Pro
25540 25545 25550
Lys Trp Arg Ile Pro Lys Leu Ser Gln Asp Asp Leu Glu Ile Val Arg
25555 25560 25565
Pro Ala Arg Arg Arg Thr Pro Ser Pro Asp Tyr Asp Phe Tyr Tyr Arg
25570 25575 25580
Pro Arg Arg Arg Ser Leu Gly Asp Ile Ser Asp Glu Glu Leu Leu Leu
25585 25590 25595 25600
Pro Ile Asp Asp Tyr Leu Ala Met Lys Arg Thr Glu Glu Glu Arg Leu
25605 25610 25615
Arg Leu Glu Glu Glu Leu Glu Leu Gly Phe Ser Ala Ser Pro Pro Ser
25620 25625 25630
Arg Ser Pro Pro His Phe Glu Leu Ser Ser Leu Arg Tyr Ser Ser Pro
25635 25640 25645
Gln Ala His Val Lys Val Glu Glu Thr Arg Lys Asn Phe Arg Tyr Ser
25650 25655 25660
Thr Tyr His Ile Pro Thr Lys Ala Glu Ala Ser Thr Ser Tyr Ala Glu
25665 25670 25675 25680
Leu Arg Glu Arg His Ala Gln Ala Ala Tyr Arg Gln Pro Lys Gln Arg
25685 25690 25695
Gln Arg Ile Met Ala Glu Arg Glu Asp Glu Glu Leu Leu Arg Pro Val
25700 25705 25710
Thr Thr Thr Gln His Leu Ser Glu Tyr Lys Ser Glu Leu Asp Phe Met
25715 25720 25725
Ser Lys Glu Glu Lys Ser Arg Lys Lys Ser Arg Arg Gln Arg Glu Val
25730 25735 25740
Thr Glu Ile Thr Glu Ile Glu Glu Glu Tyr Glu Ile Ser Lys His Ala
25745 25750 25755 25760
Gln Arg Glu Ser Ser Ser Ser Ala Ser Arg Leu Leu Arg Arg Arg Arg
25765 25770 25775
Ser Leu Ser Pro Thr Tyr Ile Glu Leu Met Arg Pro Val Ser Glu Leu
25780 25785 25790
Ile Arg Ser Arg Pro Gln Pro Ala Glu Glu Tyr Glu Asp Asp Thr Glu
25795 25800 25805
Arg Arg Ser Pro Thr Pro Glu Arg Thr Arg Pro Arg Ser Pro Ser Pro
25810 25815 25820
Val Ser Ser Glu Arg Ser Leu Ser Arg Phe Glu Arg Ser Ala Arg Phe
25825 25830 25835 25840
Asp Ile Phe Ser Arg Tyr Glu Ser Met Lys Ala Ala Leu Lys Thr Gln
25845 25850 25855
Lys Thr Ser Glu Arg Lys Tyr Glu Val Leu Ser Gln Gln Pro Phe Thr
25860 25865 25870
Leu Asp His Ala Pro Arg Ile Thr Leu Arg Met Arg Ser His Arg Val
25875 25880 25885
Pro Cys Gly Gln Asn Thr Arg Phe Ile Leu Asn Val Gln Ser Lys Pro
25890 25895 25900
Thr Ala Glu Val Lys Trp Tyr His Asn Gly Val Glu Leu Gln Glu Ser
25905 25910 25915 25920
Ser Lys Ile His Tyr Thr Asn Thr Ser Gly Val Leu Thr Leu Glu Ile
25925 25930 25935
Leu Asp Cys His Thr Asp Asp Ser Gly Thr Tyr Arg Ala Val Cys Thr
25940 25945 25950
Asn Tyr Lys Gly Glu Ala Ser Asp Tyr Ala Thr Leu Asp Val Thr Gly
25955 25960 25965
Gly Asp Tyr Thr Thr Tyr Ala Ser Gln Arg Arg Asp Glu Glu Val Pro
25970 25975 25980
Arg Ser Val Phe Pro Glu Leu Thr Arg Thr Glu Ala Tyr Ala Val Pro
25985 25990 25995 26000
Ser Phe Lys Lys Thr Ser Glu Met Glu Ala Ser Ser Ser Val Arg Glu
26005 26010 26015
Val Lys Ser Gln Met Thr Glu Thr Arg Glu Ser Leu Ser Ser Tyr Glu
26020 26025 26030
His Ser Ala Ser Ala Glu Met Lys Ser Ala Ala Leu Glu Glu Lys Ser
26035 26040 26045
Leu Glu Glu Lys Ser Thr Thr Arg Lys Ile Lys Thr Thr Leu Ala Ala
26050 26055 26060
Arg Ile Leu Thr Lys Pro Arg Ser Met Thr Val Tyr Glu Gly Glu Ser
26065 26070 26075 26080
Ala Arg Phe Ser Cys Asp Thr Asp Gly Glu Pro Val Pro Thr Val Thr
26085 26090 26095
Trp Leu Arg Lys Gly Gln Val Leu Ser Thr Ser Ala Arg His Gln Val
26100 26105 26110
Thr Thr Thr Lys Tyr Lys Ser Thr Phe Glu Ile Ser Ser Val Gln Ala
26115 26120 26125
Ser Asp Glu Gly Asn Tyr Ser Val Val Val Glu Asn Ser Glu Gly Lys
26130 26135 26140
Gln Glu Ala Glu Phe Thr Leu Thr Ile Gln Lys Ala Arg Val Thr Glu
26145 26150 26155 26160
Lys Ala Val Thr Ser Pro Pro Arg Val Lys Ser Pro Glu Pro Arg Val
26165 26170 26175
Lys Ser Pro Glu Ala Val Lys Ser Pro Lys Arg Val Lys Ser Pro Glu
26180 26185 26190
Pro Ser His Pro Lys Ala Val Ser Pro Thr Glu Thr Lys Pro Thr Pro
26195 26200 26205
Arg Glu Lys Val Gln His Leu Pro Val Ser Ala Pro Pro Lys Ile Thr
26210 26215 26220
Gln Phe Leu Lys Ala Glu Ala Ser Lys Glu Ile Ala Lys Leu Thr Cys
26225 26230 26235 26240
Val Val Glu Ser Ser Val Leu Arg Ala Lys Glu Val Thr Trp Tyr Lys
26245 26250 26255
Asp Gly Lys Lys Leu Lys Glu Asn Gly His Phe Gln Phe His Tyr Ser
26260 26265 26270
Ala Asp Gly Thr Tyr Glu Leu Lys Ile Asn Asn Leu Thr Glu Ser Asp
26275 26280 26285
Gln Gly Glu Tyr Val Cys Glu Ile Ser Gly Glu Gly Gly Thr Ser Lys
26290 26295 26300
Thr Asn Leu Gln Phe Met Gly Gln Ala Phe Lys Ser Ile His Glu Lys
26305 26310 26315 26320
Val Ser Lys Ile Ser Glu Thr Lys Lys Ser Asp Gln Lys Thr Thr Glu
26325 26330 26335
Ser Thr Val Thr Arg Lys Thr Glu Pro Lys Ala Pro Glu Pro Ile Ser
26340 26345 26350
Ser Lys Pro Val Ile Val Thr Gly Leu Gln Asp Thr Thr Val Ser Ser
26355 26360 26365
Asp Ser Val Ala Lys Phe Ala Val Lys Ala Thr Gly Glu Pro Arg Pro
26370 26375 26380
Thr Ala Ile Trp Thr Lys Asp Gly Lys Ala Ile Thr Gln Gly Gly Lys
26385 26390 26395 26400
Tyr Lys Leu Ser Glu Asp Lys Gly Gly Phe Phe Leu Glu Ile His Lys
26405 26410 26415
Thr Asp Thr Ser Asp Ser Gly Leu Tyr Thr Cys Thr Val Lys Asn Ser
26420 26425 26430
Ala Gly Ser Val Ser Ser Ser Cys Lys Leu Thr Ile Lys Ala Ile Lys
26435 26440 26445
Asp Thr Glu Ala Gln Lys Val Ser Thr Gln Lys Thr Ser Glu Ile Thr
26450 26455 26460
Pro Gln Lys Lys Ala Val Val Gln Glu Glu Ile Ser Gln Lys Ala Leu
26465 26470 26475 26480
Arg Ser Glu Glu Ile Lys Met Ser Glu Ala Lys Ser Gln Glu Lys Leu
26485 26490 26495
Ala Leu Lys Glu Glu Ala Ser Lys Val Leu Ile Ser Glu Glu Val Lys
26500 26505 26510
Lys Ser Ala Ala Thr Ser Leu Glu Lys Ser Ile Val His Glu Glu Ile
26515 26520 26525
Thr Lys Thr Ser Gln Ala Ser Glu Glu Val Arg Thr His Ala Glu Ile
26530 26535 26540
Lys Ala Phe Ser Thr Gln Met Ser Ile Asn Glu Gly Gln Arg Leu Val
26545 26550 26555 26560
Leu Lys Ala Asn Ile Ala Gly Ala Thr Asp Val Lys Trp Val Leu Asn
26565 26570 26575
Gly Val Glu Leu Thr Asn Ser Glu Glu Tyr Arg Tyr Gly Val Ser Gly
26580 26585 26590
Ser Asp Gln Thr Leu Thr Ile Lys Gln Ala Ser His Arg Asp Glu Gly
26595 26600 26605
Ile Leu Thr Cys Ile Ser Lys Thr Lys Glu Gly Ile Val Lys Cys Gln
26610 26615 26620
Tyr Asp Leu Thr Leu Ser Lys Glu Leu Ser Asp Ala Pro Ala Phe Ile
26625 26630 26635 26640
Ser Gln Pro Arg Ser Gln Asn Ile Asn Glu Gly Gln Asn Val Leu Phe
26645 26650 26655
Thr Cys Glu Ile Ser Gly Glu Pro Ser Pro Glu Ile Glu Trp Phe Lys
26660 26665 26670
Asn Asn Leu Pro Ile Ser Ile Ser Ser Asn Val Ser Ile Ser Arg Ser
26675 26680 26685
Arg Asn Val Tyr Ser Leu Glu Ile Arg Asn Ala Ser Val Ser Asp Ser
26690 26695 26700
Gly Lys Tyr Thr Ile Lys Ala Lys Asn Phe Arg Gly Gln Cys Ser Ala
26705 26710 26715 26720
Thr Ala Ser Leu Met Val Leu Pro Leu Val Glu Glu Pro Ser Arg Glu
26725 26730 26735
Val Val Leu Arg Thr Ser Gly Asp Thr Ser Leu Gln Gly Ser Phe Ser
26740 26745 26750
Ser Gln Ser Val Gln Met Ser Ala Ser Lys Gln Glu Ala Ser Phe Ser
26755 26760 26765
Ser Phe Ser Ser Ser Ser Ala Ser Ser Met Thr Glu Met Lys Phe Ala
26770 26775 26780
Ser Met Ser Ala Gln Ser Met Ser Ser Met Gln Glu Ser Phe Val Glu
26785 26790 26795 26800
Met Ser Ser Ser Ser Phe Met Gly Ile Ser Asn Met Thr Gln Leu Glu
26805 26810 26815
Ser Ser Thr Ser Lys Met Leu Lys Ala Gly Ile Arg Gly Ile Pro Pro
26820 26825 26830
Lys Ile Glu Ala Leu Pro Ser Asp Ile Ser Ile Asp Glu Gly Lys Val
26835 26840 26845
Leu Thr Val Ala Cys Ala Phe Thr Gly Glu Pro Thr Pro Glu Val Thr
26850 26855 26860
Trp Ser Cys Gly Gly Arg Lys Ile His Ser Gln Glu Gln Gly Arg Phe
26865 26870 26875 26880
His Ile Glu Asn Thr Asp Asp Leu Thr Thr Leu Ile Ile Met Asp Val
26885 26890 26895
Gln Lys Gln Asp Gly Gly Leu Tyr Thr Leu Ser Leu Gly Asn Glu Phe
26900 26905 26910
Gly Ser Asp Ser Ala Thr Val Asn Ile His Ile Arg Ser Ile
26915 26920 26925
<210> 6
<211> 81940
<212> DNA
<213> Titin human nucleotide
<220>
<221> gene
<222> (1)..(81940)
<220>
<221> CDS
<222> (133)..(80910)
<400> 6
attagaggct caccgattca tgtcggagat ggtcagaaaa accaactctc cataggacgt 60
cgtttcagaa gcaaccttgg gcttagtccc acccttttta ggcactcttg agaaatcaga 120
gtgcctagaa ag atg aca act caa gca ccg acg ttt acg cag ccg 165
Met Thr Thr Gln Ala Pro Thr Phe Thr Gln Pro
1 5 10
tta caa agc gtt gtg gta ctg gag ggt agt acc gca acc ttt gag gct 213
Leu Gln Ser Val Val Val Leu Glu Gly Ser Thr Ala Thr Phe Glu Ala
15 20 25
cac att agt ggt ttt cca gtt cct gag gtg agc tgg ttt agg gat ggc 261
His Ile Ser Gly Phe Pro Val Pro Glu Val Ser Trp Phe Arg Asp Gly
30 35 40
cag gtg att tcc act tcc act ctg ccc ggc gtg cag atc tcc ttt agc 309
Gln Val Ile Ser Thr Ser Thr Leu Pro Gly Val Gln Ile Ser Phe Ser
45 50 55
gat ggc cgc gct aaa ctg acg atc ccc gcc gtg act aaa gcc aac agt 357
Asp Gly Arg Ala Lys Leu Thr Ile Pro Ala Val Thr Lys Ala Asn Ser
60 65 70 75
gga cga tat tcc ctg aaa gcc acc aat gga tct gga caa gcg act agt 405
Gly Arg Tyr Ser Leu Lys Ala Thr Asn Gly Ser Gly Gln Ala Thr Ser
80 85 90
act gct gag ctt ctc gtg aaa gct gag aca gca cca ccc aac ttc gtt 453
Thr Ala Glu Leu Leu Val Lys Ala Glu Thr Ala Pro Pro Asn Phe Val
95 100 105
caa cga ctg cag agc atg acc gtg aga caa gga agc caa gtg aga ctc 501
Gln Arg Leu Gln Ser Met Thr Val Arg Gln Gly Ser Gln Val Arg Leu
110 115 120
caa gtg aga gtg act gga atc cct aac cct gtg gtg aag ttc tac cgg 549
Gln Val Arg Val Thr Gly Ile Pro Asn Pro Val Val Lys Phe Tyr Arg
125 130 135
gat gga gcc gaa atc cag agc tcc ctt gat ttc caa att tca caa gaa 597
Asp Gly Ala Glu Ile Gln Ser Ser Leu Asp Phe Gln Ile Ser Gln Glu
140 145 150 155
ggc gac ctc tac agc tta ctg att gca gaa gca tac cct gag gac tca 645
Gly Asp Leu Tyr Ser Leu Leu Ile Ala Glu Ala Tyr Pro Glu Asp Ser
160 165 170
ggg acc tat tca gta aat gcc acc aat agc gtt gga aga gct act tcg 693
Gly Thr Tyr Ser Val Asn Ala Thr Asn Ser Val Gly Arg Ala Thr Ser
175 180 185
act gct gaa tta ctg gtt caa ggt gaa gaa gaa gta cct gct aaa aag 741
Thr Ala Glu Leu Leu Val Gln Gly Glu Glu Glu Val Pro Ala Lys Lys
190 195 200
aca aag aca att gtt tcg act gct cag atc tca gaa tca aga caa acc 789
Thr Lys Thr Ile Val Ser Thr Ala Gln Ile Ser Glu Ser Arg Gln Thr
205 210 215
cga att gaa aag aag att gaa gcc cac ttt gat gcc aga tca att gca 837
Arg Ile Glu Lys Lys Ile Glu Ala His Phe Asp Ala Arg Ser Ile Ala
220 225 230 235
aca gtt gag atg gtc ata gat ggt gcc gct ggg caa cag ctg cca cat 885
Thr Val Glu Met Val Ile Asp Gly Ala Ala Gly Gln Gln Leu Pro His
240 245 250
aaa aca cct ccc agg att cct ccg aag cca aag tca aga tcc cca aca 933
Lys Thr Pro Pro Arg Ile Pro Pro Lys Pro Lys Ser Arg Ser Pro Thr
255 260 265
cca ccg tct att gct gcc aaa gca cag ctg gct cgg cag cag tcc cca 981
Pro Pro Ser Ile Ala Ala Lys Ala Gln Leu Ala Arg Gln Gln Ser Pro
270 275 280
tcg ccc ata aga cac tcc cct tcc ccg gtc aga cac gtg cgg gca ccg 1029
Ser Pro Ile Arg His Ser Pro Ser Pro Val Arg His Val Arg Ala Pro
285 290 295
acc cca tct ccg gtc agg tcc gtg tct cca gca gca aga atc tcc aca 1077
Thr Pro Ser Pro Val Arg Ser Val Ser Pro Ala Ala Arg Ile Ser Thr
300 305 310 315
tcc ccc atc agg tct gtt agg tct cca ttg ctc atg cgt aag act cag 1125
Ser Pro Ile Arg Ser Val Arg Ser Pro Leu Leu Met Arg Lys Thr Gln
320 325 330
gca tcc acc gtg gcc aca ggt cct gaa gtg cct ccc cct tgg aag caa 1173
Ala Ser Thr Val Ala Thr Gly Pro Glu Val Pro Pro Pro Trp Lys Gln
335 340 345
gag ggc tac gtg gcc tcc tca tct gag gct gag atg aga gag aca acg 1221
Glu Gly Tyr Val Ala Ser Ser Ser Glu Ala Glu Met Arg Glu Thr Thr
350 355 360
ctg aca acc tct act cag atc agg aca gaa gag aga tgg gaa ggg aga 1269
Leu Thr Thr Ser Thr Gln Ile Arg Thr Glu Glu Arg Trp Glu Gly Arg
365 370 375
tac ggt gtc cag gag caa gtg acc atc agt ggt gct gcg ggt gct gcc 1317
Tyr Gly Val Gln Glu Gln Val Thr Ile Ser Gly Ala Ala Gly Ala Ala
380 385 390 395
gcc agt gtg tcg gcc agt gct agc tac gca gca gag gct gtt gcc act 1365
Ala Ser Val Ser Ala Ser Ala Ser Tyr Ala Ala Glu Ala Val Ala Thr
400 405 410
ggt gct aaa gag gtg aaa caa gat gct gac aaa agt gca gct gtt gcg 1413
Gly Ala Lys Glu Val Lys Gln Asp Ala Asp Lys Ser Ala Ala Val Ala
415 420 425
act gtt gtt gct gcc gtt gat atg gcc aga gtg aga gaa cca gtg atc 1461
Thr Val Val Ala Ala Val Asp Met Ala Arg Val Arg Glu Pro Val Ile
430 435 440
agc gct gta gag cag act gct cag agg aca acc acg act gct gtg cac 1509
Ser Ala Val Glu Gln Thr Ala Gln Arg Thr Thr Thr Thr Ala Val His
445 450 455
atc caa cct gct caa gaa cag gta aga aag gaa gcg gag aag act gct 1557
Ile Gln Pro Ala Gln Glu Gln Val Arg Lys Glu Ala Glu Lys Thr Ala
460 465 470 475
gta act aag gta gta gtg gcc gcc gat aaa gcc aag gaa caa gaa tta 1605
Val Thr Lys Val Val Val Ala Ala Asp Lys Ala Lys Glu Gln Glu Leu
480 485 490
aaa tca aga acc aaa gaa ata att acc aca aag caa gag cag atg cac 1653
Lys Ser Arg Thr Lys Glu Ile Ile Thr Thr Lys Gln Glu Gln Met His
495 500 505
gta act cat gag cag ata aga aaa gaa act gaa aaa aca ttt gta cca 1701
Val Thr His Glu Gln Ile Arg Lys Glu Thr Glu Lys Thr Phe Val Pro
510 515 520
aag gta gta att tcc gca gct aaa gcc aaa gaa caa gaa act aga att 1749
Lys Val Val Ile Ser Ala Ala Lys Ala Lys Glu Gln Glu Thr Arg Ile
525 530 535
tct gaa gaa att act aag aaa cag aaa caa gta act caa gaa gca ata 1797
Ser Glu Glu Ile Thr Lys Lys Gln Lys Gln Val Thr Gln Glu Ala Ile
540 545 550 555
atg aag gaa act agg aaa aca gtt gta cct aaa gtc ata gtt gcc aca 1845
Met Lys Glu Thr Arg Lys Thr Val Val Pro Lys Val Ile Val Ala Thr
560 565 570
ccc aaa gtc aaa gaa caa gat tta gta tca aga ggt aga gaa ggc att 1893
Pro Lys Val Lys Glu Gln Asp Leu Val Ser Arg Gly Arg Glu Gly Ile
575 580 585
act acc aaa aga gaa caa gtg caa ata act cag gag aag atg aga aag 1941
Thr Thr Lys Arg Glu Gln Val Gln Ile Thr Gln Glu Lys Met Arg Lys
590 595 600
gaa gcc gag aaa act gcc ttg tct aca ata gca gtt gct act gct aaa 1989
Glu Ala Glu Lys Thr Ala Leu Ser Thr Ile Ala Val Ala Thr Ala Lys
605 610 615
gcc aaa gaa caa gaa aca ata ctg aga act aga gaa act atg gct act 2037
Ala Lys Glu Gln Glu Thr Ile Leu Arg Thr Arg Glu Thr Met Ala Thr
620 625 630 635
aga caa gaa caa atc caa gtt acc cat gga aag gtg gac gtt gga aaa 2085
Arg Gln Glu Gln Ile Gln Val Thr His Gly Lys Val Asp Val Gly Lys
640 645 650
aag gct gaa gct gta gca aca gtt gtt gct gca gta gac cag gcc cga 2133
Lys Ala Glu Ala Val Ala Thr Val Val Ala Ala Val Asp Gln Ala Arg
655 660 665
gtc aga gag ccc aga gag cct ggg cat ctt gaa gaa tcc tat gct cag 2181
Val Arg Glu Pro Arg Glu Pro Gly His Leu Glu Glu Ser Tyr Ala Gln
670 675 680
cag acc act ttg gag tac gga tat aag gaa cgc att tcc gcc gca aag 2229
Gln Thr Thr Leu Glu Tyr Gly Tyr Lys Glu Arg Ile Ser Ala Ala Lys
685 690 695
gta gct gag cct ccc caa cgt cca gcc tca gaa ccc cac gtt gtc cct 2277
Val Ala Glu Pro Pro Gln Arg Pro Ala Ser Glu Pro His Val Val Pro
700 705 710 715
aaa gca gtc aag cct aga gta atc cag gct cct tct gag act cat atc 2325
Lys Ala Val Lys Pro Arg Val Ile Gln Ala Pro Ser Glu Thr His Ile
720 725 730
aaa act act gat caa aag gga atg cac ata tca tca cag atc aag aaa 2373
Lys Thr Thr Asp Gln Lys Gly Met His Ile Ser Ser Gln Ile Lys Lys
735 740 745
act aca gat cta aca acg gaa aga tta gtc cat gtg gat aaa cgc ccc 2421
Thr Thr Asp Leu Thr Thr Glu Arg Leu Val His Val Asp Lys Arg Pro
750 755 760
cgc aca gct agc cct cac ttt act gtt tca aaa att tct gtt cct aag 2469
Arg Thr Ala Ser Pro His Phe Thr Val Ser Lys Ile Ser Val Pro Lys
765 770 775
aca gaa cat gga tat gag gca tca ata gcc ggt agt gct att gcc aca 2517
Thr Glu His Gly Tyr Glu Ala Ser Ile Ala Gly Ser Ala Ile Ala Thr
780 785 790 795
tta caa aaa gag ttg tca gcc aca tct tct gct cag aag atc acc aaa 2565
Leu Gln Lys Glu Leu Ser Ala Thr Ser Ser Ala Gln Lys Ile Thr Lys
800 805 810
tcg gtg aag gct cct act gtg aag ccc agt gag act aga gta agg gca 2613
Ser Val Lys Ala Pro Thr Val Lys Pro Ser Glu Thr Arg Val Arg Ala
815 820 825
gag ccc aca ccc ttg cca cag ttc ccc ttc gct gac aca cca gat act 2661
Glu Pro Thr Pro Leu Pro Gln Phe Pro Phe Ala Asp Thr Pro Asp Thr
830 835 840
tac aag agt gaa gct ggc gtt gag gtg aaa aag gaa gta ggg gtg agc 2709
Tyr Lys Ser Glu Ala Gly Val Glu Val Lys Lys Glu Val Gly Val Ser
845 850 855
atc act ggc acc acc gtc cgt gaa gag cgc ttt gaa gta ctg cac gga 2757
Ile Thr Gly Thr Thr Val Arg Glu Glu Arg Phe Glu Val Leu His Gly
860 865 870 875
cgc gaa gcc aag gta aca gaa aca gca aga gta cca gca cct gtt gaa 2805
Arg Glu Ala Lys Val Thr Glu Thr Ala Arg Val Pro Ala Pro Val Glu
880 885 890
att cct gtt act cca cca act ttg gtc tcg ggc tta aaa aat gtg act 2853
Ile Pro Val Thr Pro Pro Thr Leu Val Ser Gly Leu Lys Asn Val Thr
895 900 905
gtc ata gaa ggt gaa tct gtc acc ttg gag tgc cac atc tct gga tac 2901
Val Ile Glu Gly Glu Ser Val Thr Leu Glu Cys His Ile Ser Gly Tyr
910 915 920
cca tcc ccg aca gtg aca tgg tac agg gaa gac tac caa atc gaa agt 2949
Pro Ser Pro Thr Val Thr Trp Tyr Arg Glu Asp Tyr Gln Ile Glu Ser
925 930 935
tcc att gac ttc cag ata acc ttc cag agt gga att gct cgt ctt atg 2997
Ser Ile Asp Phe Gln Ile Thr Phe Gln Ser Gly Ile Ala Arg Leu Met
940 945 950 955
att cgc gaa gca ttt gcg gaa gac agc ggg cga ttt act tgc agt gct 3045
Ile Arg Glu Ala Phe Ala Glu Asp Ser Gly Arg Phe Thr Cys Ser Ala
960 965 970
gta aat gag gct gga acc gtc agc aca tcc tgc tat ctg gct gtg cag 3093
Val Asn Glu Ala Gly Thr Val Ser Thr Ser Cys Tyr Leu Ala Val Gln
975 980 985
gtg tca gaa gaa ttt gaa aag gaa acc aca gcc gtg act gag aaa ttt 3141
Val Ser Glu Glu Phe Glu Lys Glu Thr Thr Ala Val Thr Glu Lys Phe
990 995 1000
act aca gaa gag aaa cgc ttt gtt gag tca aga gat gtg gtt atg act 3189
Thr Thr Glu Glu Lys Arg Phe Val Glu Ser Arg Asp Val Val Met Thr
1005 1010 1015
gat act agc ctc aca gag gaa caa gca ggg cct gga gaa cct gcc gcg 3237
Asp Thr Ser Leu Thr Glu Glu Gln Ala Gly Pro Gly Glu Pro Ala Ala
1020 1025 1030 1035
cct tac ttt att aca aaa cca gtg gtc cag aaa ctg gtg gaa ggt ggg 3285
Pro Tyr Phe Ile Thr Lys Pro Val Val Gln Lys Leu Val Glu Gly Gly
1040 1045 1050
agc gtg gtg ttt gga tgc caa gtt ggc ggc aac cca aag ccc cat gta 3333
Ser Val Val Phe Gly Cys Gln Val Gly Gly Asn Pro Lys Pro His Val
1055 1060 1065
tac tgg aaa aaa tct ggt gtt cct cta acc act gga tac aga tac aaa 3381
Tyr Trp Lys Lys Ser Gly Val Pro Leu Thr Thr Gly Tyr Arg Tyr Lys
1070 1075 1080
gtg agt tac aac aaa caa acc ggt gaa tgc aag ctg gtg att tct atg 3429
Val Ser Tyr Asn Lys Gln Thr Gly Glu Cys Lys Leu Val Ile Ser Met
1085 1090 1095
act ttt gct gat gat gct gga gaa tac act att gtt gtt cgc aat aag 3477
Thr Phe Ala Asp Asp Ala Gly Glu Tyr Thr Ile Val Val Arg Asn Lys
1100 1105 1110 1115
cat gga gaa act tct gca tct gct tcc ttg ctt gaa gaa gct gat tat 3525
His Gly Glu Thr Ser Ala Ser Ala Ser Leu Leu Glu Glu Ala Asp Tyr
1120 1125 1130
gag tta ctg atg aag tcc cag caa gaa atg ctt tat cag aca caa gtg 3573
Glu Leu Leu Met Lys Ser Gln Gln Glu Met Leu Tyr Gln Thr Gln Val
1135 1140 1145
act gca ttt gtt caa gaa cct gaa gtt gga gaa aca gca cct gga ttt 3621
Thr Ala Phe Val Gln Glu Pro Glu Val Gly Glu Thr Ala Pro Gly Phe
1150 1155 1160
gta tac tct gag tat gaa aaa gag tat gaa aaa gaa caa gcc tta att 3669
Val Tyr Ser Glu Tyr Glu Lys Glu Tyr Glu Lys Glu Gln Ala Leu Ile
1165 1170 1175
agg aag aaa atg gcc aaa gat act gta gtg gtc aga act tat gta gaa 3717
Arg Lys Lys Met Ala Lys Asp Thr Val Val Val Arg Thr Tyr Val Glu
1180 1185 1190 1195
gat cag gaa ttc cat att tct tcc ttt gaa gag aga ctt att aaa gaa 3765
Asp Gln Glu Phe His Ile Ser Ser Phe Glu Glu Arg Leu Ile Lys Glu
1200 1205 1210
att gaa tat aga ata ata aag act aca tta gaa gaa ctt ctt gaa gaa 3813
Ile Glu Tyr Arg Ile Ile Lys Thr Thr Leu Glu Glu Leu Leu Glu Glu
1215 1220 1225
gat gga gaa gaa aag atg gca gtt gac att tct gaa tct gaa gct gtt 3861
Asp Gly Glu Glu Lys Met Ala Val Asp Ile Ser Glu Ser Glu Ala Val
1230 1235 1240
gaa tca gga ttt gat tta aga atc aag aat tat aga att ctt gag ggg 3909
Glu Ser Gly Phe Asp Leu Arg Ile Lys Asn Tyr Arg Ile Leu Glu Gly
1245 1250 1255
atg ggt gtc act ttt cat tgc aag atg tct gga tat cca tta cca aag 3957
Met Gly Val Thr Phe His Cys Lys Met Ser Gly Tyr Pro Leu Pro Lys
1260 1265 1270 1275
att gct tgg tac aaa gat ggc aag cgc atc aaa cat gga gaa aga tac 4005
Ile Ala Trp Tyr Lys Asp Gly Lys Arg Ile Lys His Gly Glu Arg Tyr
1280 1285 1290
caa atg gac ttt cta caa gat ggc aga gct agt ctg cgt ata cct gtt 4053
Gln Met Asp Phe Leu Gln Asp Gly Arg Ala Ser Leu Arg Ile Pro Val
1295 1300 1305
gtt ctt cca gaa gat gaa gga atc tac act gca ttt gcc agc aat att 4101
Val Leu Pro Glu Asp Glu Gly Ile Tyr Thr Ala Phe Ala Ser Asn Ile
1310 1315 1320
aaa gga aat gca att tgc tca ggg aaa ttg tat gtg gag cct gct gca 4149
Lys Gly Asn Ala Ile Cys Ser Gly Lys Leu Tyr Val Glu Pro Ala Ala
1325 1330 1335
cca ctt gga gct ccg act tac att ccc aca cta gag cca gtg agc aga 4197
Pro Leu Gly Ala Pro Thr Tyr Ile Pro Thr Leu Glu Pro Val Ser Arg
1340 1345 1350 1355
atc aga tct ctc tct cca cgt tca gtg agc agg tct cct ata cgc atg 4245
Ile Arg Ser Leu Ser Pro Arg Ser Val Ser Arg Ser Pro Ile Arg Met
1360 1365 1370
tct cct gca cgg atg tca cct gca agg atg tct cct gca cgg atg tcc 4293
Ser Pro Ala Arg Met Ser Pro Ala Arg Met Ser Pro Ala Arg Met Ser
1375 1380 1385
cct gca aga atg tcc cct gga cgt agg ctg gag gag aca gat gag tca 4341
Pro Ala Arg Met Ser Pro Gly Arg Arg Leu Glu Glu Thr Asp Glu Ser
1390 1395 1400
caa ctt gag aga cta tat aaa cca gtc ttt gtg tta aaa cct gtt tct 4389
Gln Leu Glu Arg Leu Tyr Lys Pro Val Phe Val Leu Lys Pro Val Ser
1405 1410 1415
ttc aaa tgt tta gaa ggg gca aac tgc aga ttt gac tta aag gtt gtt 4437
Phe Lys Cys Leu Glu Gly Ala Asn Cys Arg Phe Asp Leu Lys Val Val
1420 1425 1430 1435
ggt aga cct atg cca gag acg ttc tgg ttt cat gat ggc cag caa att 4485
Gly Arg Pro Met Pro Glu Thr Phe Trp Phe His Asp Gly Gln Gln Ile
1440 1445 1450
gtc aat gac tat acc cat aaa gta gtc att aaa gaa gat ggt act caa 4533
Val Asn Asp Tyr Thr His Lys Val Val Ile Lys Glu Asp Gly Thr Gln
1455 1460 1465
tca cta att att gtc cct gcc aca ccc agt gat tct ggg gaa tgg act 4581
Ser Leu Ile Ile Val Pro Ala Thr Pro Ser Asp Ser Gly Glu Trp Thr
1470 1475 1480
gtg gtt gcc caa aac agg gca ggc aga tct tca att tca gtg att tta 4629
Val Val Ala Gln Asn Arg Ala Gly Arg Ser Ser Ile Ser Val Ile Leu
1485 1490 1495
act gtg gaa gct gtg gaa cat cag gta aaa ccg atg ttt gta gaa aaa 4677
Thr Val Glu Ala Val Glu His Gln Val Lys Pro Met Phe Val Glu Lys
1500 1505 1510 1515
ctg aaa aat gtc aat ata aag gaa ggt tcc cga ctt gaa atg aaa gtc 4725
Leu Lys Asn Val Asn Ile Lys Glu Gly Ser Arg Leu Glu Met Lys Val
1520 1525 1530
aga gct acg ggt aac ccc aac cct gac att gta tgg ttg aaa aac agt 4773
Arg Ala Thr Gly Asn Pro Asn Pro Asp Ile Val Trp Leu Lys Asn Ser
1535 1540 1545
gac atc att gtg cct cat aaa tat ccc aaa atc aga att gaa gga acc 4821
Asp Ile Ile Val Pro His Lys Tyr Pro Lys Ile Arg Ile Glu Gly Thr
1550 1555 1560
aag gga gaa gct gcc ctt aaa atc gat tcc act gtc agc caa gat tct 4869
Lys Gly Glu Ala Ala Leu Lys Ile Asp Ser Thr Val Ser Gln Asp Ser
1565 1570 1575
gcc tgg tat act gcg act gct att aat aaa gct ggc aga gac act aca 4917
Ala Trp Tyr Thr Ala Thr Ala Ile Asn Lys Ala Gly Arg Asp Thr Thr
1580 1585 1590 1595
aga tgc aaa gta aat gtt gaa gtt gag ttt gca gag cct gag cca gag 4965
Arg Cys Lys Val Asn Val Glu Val Glu Phe Ala Glu Pro Glu Pro Glu
1600 1605 1610
aga aag tta atc atc cca cgg ggg aca tat aga gca aag gag att gca 5013
Arg Lys Leu Ile Ile Pro Arg Gly Thr Tyr Arg Ala Lys Glu Ile Ala
1615 1620 1625
gcc cca gaa ctg gag ccc ctc cat ttg cga tat ggc caa gag caa tgg 5061
Ala Pro Glu Leu Glu Pro Leu His Leu Arg Tyr Gly Gln Glu Gln Trp
1630 1635 1640
gaa gaa ggt gat ctc tat gac aaa gag aaa caa cag aaa cca ttt ttc 5109
Glu Glu Gly Asp Leu Tyr Asp Lys Glu Lys Gln Gln Lys Pro Phe Phe
1645 1650 1655
aag aaa aaa ctc act tcc tta aga ctt aag cgc ttt ggg cct gcc cac 5157
Lys Lys Lys Leu Thr Ser Leu Arg Leu Lys Arg Phe Gly Pro Ala His
1660 1665 1670 1675
ttt gaa tgc agg cta aca ccc att agt gac cca acg atg gtg gtg gag 5205
Phe Glu Cys Arg Leu Thr Pro Ile Ser Asp Pro Thr Met Val Val Glu
1680 1685 1690
tgg ctc cat gat gga aag cca ctt gaa gca gcc aac agg ctc cgt atg 5253
Trp Leu His Asp Gly Lys Pro Leu Glu Ala Ala Asn Arg Leu Arg Met
1695 1700 1705
atc aat gaa ttt ggg tac tgc agc ctt gat tat ggc gtt gca tat tct 5301
Ile Asn Glu Phe Gly Tyr Cys Ser Leu Asp Tyr Gly Val Ala Tyr Ser
1710 1715 1720
aga gac agt ggt atc att act tgc aga gcc act aac aaa tat gga aca 5349
Arg Asp Ser Gly Ile Ile Thr Cys Arg Ala Thr Asn Lys Tyr Gly Thr
1725 1730 1735
gat cac aca tct gct acc ctt att gtt aaa gat gag aaa agt ctt gtg 5397
Asp His Thr Ser Ala Thr Leu Ile Val Lys Asp Glu Lys Ser Leu Val
1740 1745 1750 1755
gaa gaa tcc caa ttg cct gag ggg agg aaa ggc tta cag aga att gaa 5445
Glu Glu Ser Gln Leu Pro Glu Gly Arg Lys Gly Leu Gln Arg Ile Glu
1760 1765 1770
gaa tta gag aga atg gct cat gaa ggt gca ctt aca ggt gta aca aca 5493
Glu Leu Glu Arg Met Ala His Glu Gly Ala Leu Thr Gly Val Thr Thr
1775 1780 1785
gat cag aaa gaa aag caa aag cca gac att gtc ttg tac cca gag cca 5541
Asp Gln Lys Glu Lys Gln Lys Pro Asp Ile Val Leu Tyr Pro Glu Pro
1790 1795 1800
gtt aga gta ctt gaa ggg gag act gca agg ttc cgc tgc agg gta aca 5589
Val Arg Val Leu Glu Gly Glu Thr Ala Arg Phe Arg Cys Arg Val Thr
1805 1810 1815
ggc tac cct cag ccc aaa gtc aac tgg tac ctc aat gga cag ctc atc 5637
Gly Tyr Pro Gln Pro Lys Val Asn Trp Tyr Leu Asn Gly Gln Leu Ile
1820 1825 1830 1835
cgc aaa agc aaa agg ttc aga gtt cgc tat gat ggt atc cat tac ctg 5685
Arg Lys Ser Lys Arg Phe Arg Val Arg Tyr Asp Gly Ile His Tyr Leu
1840 1845 1850
gac atc gtg gac tgc aaa tca tat gac aca ggt gaa gtg aag gtc acc 5733
Asp Ile Val Asp Cys Lys Ser Tyr Asp Thr Gly Glu Val Lys Val Thr
1855 1860 1865
gcg gaa aat cct gaa ggt gtg ata gag cat aaa gtg aag ctt gag att 5781
Ala Glu Asn Pro Glu Gly Val Ile Glu His Lys Val Lys Leu Glu Ile
1870 1875 1880
caa cag agg gaa gat ttt agg tct gtc ctt agg aga gct cct gaa cca 5829
Gln Gln Arg Glu Asp Phe Arg Ser Val Leu Arg Arg Ala Pro Glu Pro
1885 1890 1895
agg cct gag ttt cac gta cat gaa cca gga aag ctt cag ttt gaa gta 5877
Arg Pro Glu Phe His Val His Glu Pro Gly Lys Leu Gln Phe Glu Val
1900 1905 1910 1915
caa aaa gtg gat aga cct gtt gac acc act gaa acc aaa gaa gtt gtg 5925
Gln Lys Val Asp Arg Pro Val Asp Thr Thr Glu Thr Lys Glu Val Val
1920 1925 1930
aag ttg aaa agg gct gaa aga att acc cat gaa aaa gtg cct gaa gag 5973
Lys Leu Lys Arg Ala Glu Arg Ile Thr His Glu Lys Val Pro Glu Glu
1935 1940 1945
tcg gaa gag ctg cgc agt aaa ttc aag cgc aga aca gaa gag ggc tat 6021
Ser Glu Glu Leu Arg Ser Lys Phe Lys Arg Arg Thr Glu Glu Gly Tyr
1950 1955 1960
tat gaa gcc att acc gct gtg gag ctc aag tct cga aag aag gat gaa 6069
Tyr Glu Ala Ile Thr Ala Val Glu Leu Lys Ser Arg Lys Lys Asp Glu
1965 1970 1975
tcc tat gag gaa ctc ctc agg aag aca aaa gat gaa ctt ctc cac tgg 6117
Ser Tyr Glu Glu Leu Leu Arg Lys Thr Lys Asp Glu Leu Leu His Trp
1980 1985 1990 1995
acc aaa gag tta act gaa gag gaa aag aaa gct ctt gcc gaa gaa ggc 6165
Thr Lys Glu Leu Thr Glu Glu Glu Lys Lys Ala Leu Ala Glu Glu Gly
2000 2005 2010
aaa atc acg att cca act ttt aaa cct gac aag att gaa cta agt cct 6213
Lys Ile Thr Ile Pro Thr Phe Lys Pro Asp Lys Ile Glu Leu Ser Pro
2015 2020 2025
agt atg gag gct cca aaa atc ttc gaa aga atc cag agc caa aca gtg 6261
Ser Met Glu Ala Pro Lys Ile Phe Glu Arg Ile Gln Ser Gln Thr Val
2030 2035 2040
ggc caa gga tct gat gca cac ttc cgg gtc aga gtc gtg ggg aaa cca 6309
Gly Gln Gly Ser Asp Ala His Phe Arg Val Arg Val Val Gly Lys Pro
2045 2050 2055
gac ccc gaa tgt gaa tgg tac aaa aat ggt gtc aaa att gaa cgg tct 6357
Asp Pro Glu Cys Glu Trp Tyr Lys Asn Gly Val Lys Ile Glu Arg Ser
2060 2065 2070 2075
gac cgg atc tac tgg tac tgg ccc gaa gac aat gtt tgt gaa ttg gtc 6405
Asp Arg Ile Tyr Trp Tyr Trp Pro Glu Asp Asn Val Cys Glu Leu Val
2080 2085 2090
ata aga gat gtg act gct gag gac tct gcc agc atc atg gta aaa gcc 6453
Ile Arg Asp Val Thr Ala Glu Asp Ser Ala Ser Ile Met Val Lys Ala
2095 2100 2105
atc aac ata gct gga gaa acc tcc agt cac gca ttc tta ctt gtc caa 6501
Ile Asn Ile Ala Gly Glu Thr Ser Ser His Ala Phe Leu Leu Val Gln
2110 2115 2120
gcc aag caa ttg atc act ttc aca cag gaa tta caa gat gtt gtt gct 6549
Ala Lys Gln Leu Ile Thr Phe Thr Gln Glu Leu Gln Asp Val Val Ala
2125 2130 2135
aag gaa aaa gac act atg gca acc ttt gaa tgt gaa act tca gaa cca 6597
Lys Glu Lys Asp Thr Met Ala Thr Phe Glu Cys Glu Thr Ser Glu Pro
2140 2145 2150 2155
ttt gtc aaa gtg aaa tgg tat aaa gat ggt atg gag gtt cat gag gga 6645
Phe Val Lys Val Lys Trp Tyr Lys Asp Gly Met Glu Val His Glu Gly
2160 2165 2170
gat aaa tac agg atg cac tct gac aga aag gtt cac ttc ctc tcc ata 6693
Asp Lys Tyr Arg Met His Ser Asp Arg Lys Val His Phe Leu Ser Ile
2175 2180 2185
ctg acc att gat acg tct gat gct gaa gat tac agc tgt gta ctt gtg 6741
Leu Thr Ile Asp Thr Ser Asp Ala Glu Asp Tyr Ser Cys Val Leu Val
2190 2195 2200
gaa gat gaa aat gtc aaa acg act gct aaa ctt att gtt gaa ggt gca 6789
Glu Asp Glu Asn Val Lys Thr Thr Ala Lys Leu Ile Val Glu Gly Ala
2205 2210 2215
gtt gtt gag ttt gtg aaa gaa ctt cag gac ata gaa gtt cca gaa tca 6837
Val Val Glu Phe Val Lys Glu Leu Gln Asp Ile Glu Val Pro Glu Ser
2220 2225 2230 2235
tat tca gga gaa tta gag tgc att gta tcc cca gaa aat ata gaa gga 6885
Tyr Ser Gly Glu Leu Glu Cys Ile Val Ser Pro Glu Asn Ile Glu Gly
2240 2245 2250
aaa tgg tat cat aat gat gtg gag ctt aaa tcc aat ggc aaa tat aca 6933
Lys Trp Tyr His Asn Asp Val Glu Leu Lys Ser Asn Gly Lys Tyr Thr
2255 2260 2265
att aca tct cgt cgt gga cgt cag aac ctc acg gtc aag gat gta acc 6981
Ile Thr Ser Arg Arg Gly Arg Gln Asn Leu Thr Val Lys Asp Val Thr
2270 2275 2280
aag gag gac cag gga gaa tac agc ttt gtc atc gac ggg aaa aag aca 7029
Lys Glu Asp Gln Gly Glu Tyr Ser Phe Val Ile Asp Gly Lys Lys Thr
2285 2290 2295
acc tgt aaa tta aag atg aaa ccc cgc ccc att gct atc cta caa gga 7077
Thr Cys Lys Leu Lys Met Lys Pro Arg Pro Ile Ala Ile Leu Gln Gly
2300 2305 2310 2315
ctt agt gac caa aaa gtc tgt gag ggt gac att gtt cag ctt gaa gtt 7125
Leu Ser Asp Gln Lys Val Cys Glu Gly Asp Ile Val Gln Leu Glu Val
2320 2325 2330
aaa gtc tcc ttg gaa agt gtg gaa ggc gtc tgg atg aaa gac ggc caa 7173
Lys Val Ser Leu Glu Ser Val Glu Gly Val Trp Met Lys Asp Gly Gln
2335 2340 2345
gaa gtg cag ccc agt gac agg gtt cac att gtg ata gac aaa caa tct 7221
Glu Val Gln Pro Ser Asp Arg Val His Ile Val Ile Asp Lys Gln Ser
2350 2355 2360
cat atg ctg ctc att gaa gac atg act aag gaa gat gct gga aat tac 7269
His Met Leu Leu Ile Glu Asp Met Thr Lys Glu Asp Ala Gly Asn Tyr
2365 2370 2375
tct ttc acc att cca gcc ctt ggc ctc tcc acc agt ggg cgt gtc tct 7317
Ser Phe Thr Ile Pro Ala Leu Gly Leu Ser Thr Ser Gly Arg Val Ser
2380 2385 2390 2395
gtc tat agt gtg gac gtg ata aca cct cta aaa gat gtt aat gtg att 7365
Val Tyr Ser Val Asp Val Ile Thr Pro Leu Lys Asp Val Asn Val Ile
2400 2405 2410
gaa ggc acc aag gct gtg ctt gaa tgt aag gtg tca gtc cct gat gtg 7413
Glu Gly Thr Lys Ala Val Leu Glu Cys Lys Val Ser Val Pro Asp Val
2415 2420 2425
act tct gtt aag tgg tac tta aat gat gaa caa atc aag cct gat gac 7461
Thr Ser Val Lys Trp Tyr Leu Asn Asp Glu Gln Ile Lys Pro Asp Asp
2430 2435 2440
cgt gta cag gcc att gtg aaa ggt act aaa cag cga cta gtc att aac 7509
Arg Val Gln Ala Ile Val Lys Gly Thr Lys Gln Arg Leu Val Ile Asn
2445 2450 2455
cga act cat gct tca gac gaa gga cct tat aag ctg ata gtt ggc aga 7557
Arg Thr His Ala Ser Asp Glu Gly Pro Tyr Lys Leu Ile Val Gly Arg
2460 2465 2470 2475
gtt gaa acc aac tgt aat ctc tct gta gaa aaa att aaa att atc aga 7605
Val Glu Thr Asn Cys Asn Leu Ser Val Glu Lys Ile Lys Ile Ile Arg
2480 2485 2490
ggt ctt cgt gac ctt acc tgt aca gaa act caa aat gtg gtg ttt gag 7653
Gly Leu Arg Asp Leu Thr Cys Thr Glu Thr Gln Asn Val Val Phe Glu
2495 2500 2505
gtt gag ctg tcc cac tct gga att gat gtc ctg tgg aat ttt aag gac 7701
Val Glu Leu Ser His Ser Gly Ile Asp Val Leu Trp Asn Phe Lys Asp
2510 2515 2520
aag gaa atc aag ccc agt tct aaa tat aaa att gaa gca cat gga aaa 7749
Lys Glu Ile Lys Pro Ser Ser Lys Tyr Lys Ile Glu Ala His Gly Lys
2525 2530 2535
ata tat aaa ttg aca gtt cta aat atg atg aaa gat gat gaa gga aaa 7797
Ile Tyr Lys Leu Thr Val Leu Asn Met Met Lys Asp Asp Glu Gly Lys
2540 2545 2550 2555
tac aca ttt tac gcg gga gaa aat atg aca tct gga aaa ctt act gtg 7845
Tyr Thr Phe Tyr Ala Gly Glu Asn Met Thr Ser Gly Lys Leu Thr Val
2560 2565 2570
gca ggt ggg gcc atc tcc aag cca ctc aca gat cag acc gta gct gaa 7893
Ala Gly Gly Ala Ile Ser Lys Pro Leu Thr Asp Gln Thr Val Ala Glu
2575 2580 2585
tcc cag gaa gct gtg ttt gaa tgt gaa gtt gcc aac cca gat tcc aaa 7941
Ser Gln Glu Ala Val Phe Glu Cys Glu Val Ala Asn Pro Asp Ser Lys
2590 2595 2600
ggc gaa tgg ttg agg gat ggc aaa cac cta cca ctg act aac aac atc 7989
Gly Glu Trp Leu Arg Asp Gly Lys His Leu Pro Leu Thr Asn Asn Ile
2605 2610 2615
aga agt gag tct gat ggc cac aaa agg aga ctt atc att gct gcc acc 8037
Arg Ser Glu Ser Asp Gly His Lys Arg Arg Leu Ile Ile Ala Ala Thr
2620 2625 2630 2635
aaa tta gat gac att gga gaa tat acc tac aag gtg gcc acc tcc aaa 8085
Lys Leu Asp Asp Ile Gly Glu Tyr Thr Tyr Lys Val Ala Thr Ser Lys
2640 2645 2650
aca tct gcc aaa ctc aaa gtt gaa gct gtc aaa att aag aag act ctg 8133
Thr Ser Ala Lys Leu Lys Val Glu Ala Val Lys Ile Lys Lys Thr Leu
2655 2660 2665
aag aac ctc aca gtg aca gaa aca cag gat gct gtt ttc act gtc gag 8181
Lys Asn Leu Thr Val Thr Glu Thr Gln Asp Ala Val Phe Thr Val Glu
2670 2675 2680
ctt aca cac cct aat gtc aaa ggt gtc cag tgg atc aaa aat gga gtt 8229
Leu Thr His Pro Asn Val Lys Gly Val Gln Trp Ile Lys Asn Gly Val
2685 2690 2695
gtg ctg gaa tcc aat gaa aag tat gct atc tct gtc aaa gga aca att 8277
Val Leu Glu Ser Asn Glu Lys Tyr Ala Ile Ser Val Lys Gly Thr Ile
2700 2705 2710 2715
tac tct ctg agg att aaa aac tgt gcc atc gtg gat gag tct gtt tat 8325
Tyr Ser Leu Arg Ile Lys Asn Cys Ala Ile Val Asp Glu Ser Val Tyr
2720 2725 2730
ggc ttc agg ctt gga agg ctt gga gcc agt gcc aga ctg cac gtg gag 8373
Gly Phe Arg Leu Gly Arg Leu Gly Ala Ser Ala Arg Leu His Val Glu
2735 2740 2745
act gtc aag atc att aaa aag cca aag gat gtg aca gcc ttg gaa aat 8421
Thr Val Lys Ile Ile Lys Lys Pro Lys Asp Val Thr Ala Leu Glu Asn
2750 2755 2760
gcc act gtt gcc ttt gaa gtt agt gtt tcc cat gac act gtt cca gta 8469
Ala Thr Val Ala Phe Glu Val Ser Val Ser His Asp Thr Val Pro Val
2765 2770 2775
aaa tgg ttc cat aag agt gtg gaa att aag cca agt gac aaa cac aga 8517
Lys Trp Phe His Lys Ser Val Glu Ile Lys Pro Ser Asp Lys His Arg
2780 2785 2790 2795
ctg gtc tca gaa agg aaa gtc cac aag ctg atg ctg cag aac atc tcc 8565
Leu Val Ser Glu Arg Lys Val His Lys Leu Met Leu Gln Asn Ile Ser
2800 2805 2810
ccc tca gat gct ggg gaa tac aca gct gtg gtc ggg caa ttg gaa tgc 8613
Pro Ser Asp Ala Gly Glu Tyr Thr Ala Val Val Gly Gln Leu Glu Cys
2815 2820 2825
aaa gca aaa ctg ttt gtg gag aca tta cat att aca aaa acc atg aaa 8661
Lys Ala Lys Leu Phe Val Glu Thr Leu His Ile Thr Lys Thr Met Lys
2830 2835 2840
aat atc gag gtg cct gag acc aaa act gcc tct ttt gag tgt gag gtg 8709
Asn Ile Glu Val Pro Glu Thr Lys Thr Ala Ser Phe Glu Cys Glu Val
2845 2850 2855
tcc cac ttc aat gtc cct tcc atg tgg ctg aag aat ggt gtg gaa att 8757
Ser His Phe Asn Val Pro Ser Met Trp Leu Lys Asn Gly Val Glu Ile
2860 2865 2870 2875
gag atg agt gaa aag ttc aag ata gtt gtg cag gga aaa ctc cat cag 8805
Glu Met Ser Glu Lys Phe Lys Ile Val Val Gln Gly Lys Leu His Gln
2880 2885 2890
ctg atc atc atg aac acc agc aca gag gac tcg gca gaa tac aca ttt 8853
Leu Ile Ile Met Asn Thr Ser Thr Glu Asp Ser Ala Glu Tyr Thr Phe
2895 2900 2905
gtc tgt ggc aat gac caa gtc agt gcc acc ctg aca gtc act cca atc 8901
Val Cys Gly Asn Asp Gln Val Ser Ala Thr Leu Thr Val Thr Pro Ile
2910 2915 2920
atg att act tcc atg ctg aaa gac atc aac gct gaa gaa aaa gac act 8949
Met Ile Thr Ser Met Leu Lys Asp Ile Asn Ala Glu Glu Lys Asp Thr
2925 2930 2935
att act ttt gag gtg aca gtg aac tat gaa ggc atc tct tac aaa tgg 8997
Ile Thr Phe Glu Val Thr Val Asn Tyr Glu Gly Ile Ser Tyr Lys Trp
2940 2945 2950 2955
tta aag aat ggt gtg gaa atc aaa tca act gac aag tgc cag atg aga 9045
Leu Lys Asn Gly Val Glu Ile Lys Ser Thr Asp Lys Cys Gln Met Arg
2960 2965 2970
acc aaa aag ctc aca cac tca ctg aac atc agg aat gtt cac ttt ggg 9093
Thr Lys Lys Leu Thr His Ser Leu Asn Ile Arg Asn Val His Phe Gly
2975 2980 2985
gat gct gct gac tac acc ttt gtg gct gga aaa gca aca tca aca gcc 9141
Asp Ala Ala Asp Tyr Thr Phe Val Ala Gly Lys Ala Thr Ser Thr Ala
2990 2995 3000
aca ctt tat gtg gaa gct cgt cat ata gaa ttt agg aaa cac att aag 9189
Thr Leu Tyr Val Glu Ala Arg His Ile Glu Phe Arg Lys His Ile Lys
3005 3010 3015
gac att aag gta ctg gag aag aag cga gcc atg ttt gaa tgt gaa gtt 9237
Asp Ile Lys Val Leu Glu Lys Lys Arg Ala Met Phe Glu Cys Glu Val
3020 3025 3030 3035
tct gaa cct gac atc act gta cag tgg atg aaa gat gac cag gaa ctg 9285
Ser Glu Pro Asp Ile Thr Val Gln Trp Met Lys Asp Asp Gln Glu Leu
3040 3045 3050
cag atc aca gac aga ata aag att cag aag gag aaa tat gtc cac cgc 9333
Gln Ile Thr Asp Arg Ile Lys Ile Gln Lys Glu Lys Tyr Val His Arg
3055 3060 3065
ctt ctg atc cca tcc acc cgg atg tct gat gct ggg aag tac aca gtg 9381
Leu Leu Ile Pro Ser Thr Arg Met Ser Asp Ala Gly Lys Tyr Thr Val
3070 3075 3080
gtg gca gga ggc aac gtg tca act gca aaa ctc ttt gta gaa ggc aga 9429
Val Ala Gly Gly Asn Val Ser Thr Ala Lys Leu Phe Val Glu Gly Arg
3085 3090 3095
gat gtt cgc atc cga agt att aaa aag gag gtt cag gtc att gag aaa 9477
Asp Val Arg Ile Arg Ser Ile Lys Lys Glu Val Gln Val Ile Glu Lys
3100 3105 3110 3115
cag cgt gct gtt gtt gaa ttt gag gtc aat gaa gac gat gtt gat gcc 9525
Gln Arg Ala Val Val Glu Phe Glu Val Asn Glu Asp Asp Val Asp Ala
3120 3125 3130
cac tgg tat aaa gat ggc att gaa atc aat ttc caa gtt caa gaa cga 9573
His Trp Tyr Lys Asp Gly Ile Glu Ile Asn Phe Gln Val Gln Glu Arg
3135 3140 3145
cac aaa tat gta gtg gaa aga aga atc cac cga atg ttt atc tct gag 9621
His Lys Tyr Val Val Glu Arg Arg Ile His Arg Met Phe Ile Ser Glu
3150 3155 3160
acc aga cag agc gat gca gga gaa tac acc ttt gtg gca gga agg aac 9669
Thr Arg Gln Ser Asp Ala Gly Glu Tyr Thr Phe Val Ala Gly Arg Asn
3165 3170 3175
agg agt tct gtc act ctc tat gtc aat gct cct gaa ccg ccc caa gtt 9717
Arg Ser Ser Val Thr Leu Tyr Val Asn Ala Pro Glu Pro Pro Gln Val
3180 3185 3190 3195
ctg cag gag ctc cag cct gtc act gtg cag tct ggc aag cct gcc cgc 9765
Leu Gln Glu Leu Gln Pro Val Thr Val Gln Ser Gly Lys Pro Ala Arg
3200 3205 3210
ttc tgt gcc atg ata tcc gga aga cca cag ccc aaa att tcc tgg tac 9813
Phe Cys Ala Met Ile Ser Gly Arg Pro Gln Pro Lys Ile Ser Trp Tyr
3215 3220 3225
aag gaa gag cag ctg ctt tcc act ggc ttc aag tgc aaa ttt ctt cat 9861
Lys Glu Glu Gln Leu Leu Ser Thr Gly Phe Lys Cys Lys Phe Leu His
3230 3235 3240
gat ggg caa gag tac acg ctt ttg cta att gaa gcc ttc cca gag gat 9909
Asp Gly Gln Glu Tyr Thr Leu Leu Leu Ile Glu Ala Phe Pro Glu Asp
3245 3250 3255
gcg gca gtc tat acc tgt gaa gcc aag aat gac tat ggt gtt gcc aca 9957
Ala Ala Val Tyr Thr Cys Glu Ala Lys Asn Asp Tyr Gly Val Ala Thr
3260 3265 3270 3275
aca tca gct tca ctc tca gtg gaa gtt cca gaa gtt gtg tct cct gat 10005
Thr Ser Ala Ser Leu Ser Val Glu Val Pro Glu Val Val Ser Pro Asp
3280 3285 3290
cag gaa atg cct gtt tat cca cct gcc atc atc acc ccg ctt cag gac 10053
Gln Glu Met Pro Val Tyr Pro Pro Ala Ile Ile Thr Pro Leu Gln Asp
3295 3300 3305
act gtc act tct gaa ggg cag cca gcc cgt ttt caa tgc cgg gtt tct 10101
Thr Val Thr Ser Glu Gly Gln Pro Ala Arg Phe Gln Cys Arg Val Ser
3310 3315 3320
gga aca gat cta aaa gtg tcg tgg tac agc aaa gac aag aaa atc aag 10149
Gly Thr Asp Leu Lys Val Ser Trp Tyr Ser Lys Asp Lys Lys Ile Lys
3325 3330 3335
cca tct cgg ttc ttt aga atg act caa ttt gaa gac act tat caa ctg 10197
Pro Ser Arg Phe Phe Arg Met Thr Gln Phe Glu Asp Thr Tyr Gln Leu
3340 3345 3350 3355
gaa att gcc gaa gct tat cca gaa gat gaa gga act tac acg ttt gtt 10245
Glu Ile Ala Glu Ala Tyr Pro Glu Asp Glu Gly Thr Tyr Thr Phe Val
3360 3365 3370
gct aat aat gct gta ggc caa gta tca agc aca gcc aac ctg agt ctg 10293
Ala Asn Asn Ala Val Gly Gln Val Ser Ser Thr Ala Asn Leu Ser Leu
3375 3380 3385
gaa gct cct gaa tca att ttg cat gag agg att gaa caa gag att gag 10341
Glu Ala Pro Glu Ser Ile Leu His Glu Arg Ile Glu Gln Glu Ile Glu
3390 3395 3400
atg gaa atg aaa gag ttt tct agt tct ttt ctg tct gcc gag gaa gaa 10389
Met Glu Met Lys Glu Phe Ser Ser Ser Phe Leu Ser Ala Glu Glu Glu
3405 3410 3415
gga ctt cat agc gcc gaa ctt caa tta tct aaa ata aat gaa aca ctt 10437
Gly Leu His Ser Ala Glu Leu Gln Leu Ser Lys Ile Asn Glu Thr Leu
3420 3425 3430 3435
gaa ctt ttg tct gaa tct cca gtt tac cca act aaa ttt gat tcc gaa 10485
Glu Leu Leu Ser Glu Ser Pro Val Tyr Pro Thr Lys Phe Asp Ser Glu
3440 3445 3450
aag gaa ggc act ggc cca att ttc atc aaa gaa gtg tca aat gct gat 10533
Lys Glu Gly Thr Gly Pro Ile Phe Ile Lys Glu Val Ser Asn Ala Asp
3455 3460 3465
ata agc atg ggg gat gtg gct aca ctg tct gta act gtc att ggc atc 10581
Ile Ser Met Gly Asp Val Ala Thr Leu Ser Val Thr Val Ile Gly Ile
3470 3475 3480
ccc aaa cct aaa att cag tgg ttc ttt aat gga gtg cta tta acc cct 10629
Pro Lys Pro Lys Ile Gln Trp Phe Phe Asn Gly Val Leu Leu Thr Pro
3485 3490 3495
tct gct gac tac aaa ttt gtt ttt gac ggt gat gat cat agc ctg atc 10677
Ser Ala Asp Tyr Lys Phe Val Phe Asp Gly Asp Asp His Ser Leu Ile
3500 3505 3510 3515
att ctg ttc acc aaa ttg gag gat gag gga gag tat aca tgt atg gcc 10725
Ile Leu Phe Thr Lys Leu Glu Asp Glu Gly Glu Tyr Thr Cys Met Ala
3520 3525 3530
agt aat gac tat gga aag aca ata tgt agt gcc tat cta aaa att aat 10773
Ser Asn Asp Tyr Gly Lys Thr Ile Cys Ser Ala Tyr Leu Lys Ile Asn
3535 3540 3545
tcc aaa gga gag ggt cac aaa gac act gaa aca gaa tca gca gtg gca 10821
Ser Lys Gly Glu Gly His Lys Asp Thr Glu Thr Glu Ser Ala Val Ala
3550 3555 3560
aaa tct ctg gaa aag ctg gga ggt cct tgt cct cct cac ttc ctt aag 10869
Lys Ser Leu Glu Lys Leu Gly Gly Pro Cys Pro Pro His Phe Leu Lys
3565 3570 3575
gag tta aaa cca att cgc tgt gct caa ggg ctt cct gcc atc ttt gag 10917
Glu Leu Lys Pro Ile Arg Cys Ala Gln Gly Leu Pro Ala Ile Phe Glu
3580 3585 3590 3595
tac aca gtg gtt gga gag cct gcc cct act gtt aca tgg ttc aaa gaa 10965
Tyr Thr Val Val Gly Glu Pro Ala Pro Thr Val Thr Trp Phe Lys Glu
3600 3605 3610
aac aag cag ctt tgc acc agt gtt tat tac act atc att cat aac cct 11013
Asn Lys Gln Leu Cys Thr Ser Val Tyr Tyr Thr Ile Ile His Asn Pro
3615 3620 3625
aat ggc tct gga act ttc att gtc aat gac cct cag agg gaa gac agt 11061
Asn Gly Ser Gly Thr Phe Ile Val Asn Asp Pro Gln Arg Glu Asp Ser
3630 3635 3640
ggc ctc tat atc tgt aaa gca gag aat atg ttg ggt gag tcc acc tgt 11109
Gly Leu Tyr Ile Cys Lys Ala Glu Asn Met Leu Gly Glu Ser Thr Cys
3645 3650 3655
gca gca gag ctg ctt gtg ctt ctg gaa gac aca gac atg act gat acc 11157
Ala Ala Glu Leu Leu Val Leu Leu Glu Asp Thr Asp Met Thr Asp Thr
3660 3665 3670 3675
ccc tgc aaa gca aag tcc aca cca gag gct cct gag gat ttt cca cag 11205
Pro Cys Lys Ala Lys Ser Thr Pro Glu Ala Pro Glu Asp Phe Pro Gln
3680 3685 3690
aca ccc tta aag ggt ccc gca gtt gaa gca ctt gac tcg gag cag gaa 11253
Thr Pro Leu Lys Gly Pro Ala Val Glu Ala Leu Asp Ser Glu Gln Glu
3695 3700 3705
att gca acg ttt gta aaa gac acc att ttg aaa gct gct tta att aca 11301
Ile Ala Thr Phe Val Lys Asp Thr Ile Leu Lys Ala Ala Leu Ile Thr
3710 3715 3720
gaa gaa aac cag caa cta tct tat gag cat att gct aaa gcc aat gaa 11349
Glu Glu Asn Gln Gln Leu Ser Tyr Glu His Ile Ala Lys Ala Asn Glu
3725 3730 3735
ttg agc agt cag ctt cct ttg gga gct cag gaa ttg caa tcc att ttg 11397
Leu Ser Ser Gln Leu Pro Leu Gly Ala Gln Glu Leu Gln Ser Ile Leu
3740 3745 3750 3755
gag caa gac aag ctc act cct gaa agc acc agg gaa ttt ctt tgc atc 11445
Glu Gln Asp Lys Leu Thr Pro Glu Ser Thr Arg Glu Phe Leu Cys Ile
3760 3765 3770
aat ggc agt att cac ttt cag cct ctc aag gaa cca tct ccc aac cta 11493
Asn Gly Ser Ile His Phe Gln Pro Leu Lys Glu Pro Ser Pro Asn Leu
3775 3780 3785
cag ctg cag att gta cag tcc cag aaa acc ttc tcc aaa gaa ggt att 11541
Gln Leu Gln Ile Val Gln Ser Gln Lys Thr Phe Ser Lys Glu Gly Ile
3790 3795 3800
cta atg cct gaa gag cct gag aca cag gca gtt cta tca gat acc gag 11589
Leu Met Pro Glu Glu Pro Glu Thr Gln Ala Val Leu Ser Asp Thr Glu
3805 3810 3815
aaa atc ttc cca agt gcc atg tcc ata gaa caa att aat tca tta aca 11637
Lys Ile Phe Pro Ser Ala Met Ser Ile Glu Gln Ile Asn Ser Leu Thr
3820 3825 3830 3835
gtt gag cct ctg aaa act tta tta gct gaa cct gaa ggg aat tat cca 11685
Val Glu Pro Leu Lys Thr Leu Leu Ala Glu Pro Glu Gly Asn Tyr Pro
3840 3845 3850
cag tct tca ata gaa cct cca atg cat tct tat cta acc tct gtg gct 11733
Gln Ser Ser Ile Glu Pro Pro Met His Ser Tyr Leu Thr Ser Val Ala
3855 3860 3865
gag gaa gta ctt tca cta aaa gaa aag aca gta tct gac acc aac aga 11781
Glu Glu Val Leu Ser Leu Lys Glu Lys Thr Val Ser Asp Thr Asn Arg
3870 3875 3880
gag caa aga gtg act ctt caa aag caa gag gca caa agt gcg ctc atc 11829
Glu Gln Arg Val Thr Leu Gln Lys Gln Glu Ala Gln Ser Ala Leu Ile
3885 3890 3895
ttg agt cag agc tta gct gag gga cac gtg gag agt ctc cag agt cct 11877
Leu Ser Gln Ser Leu Ala Glu Gly His Val Glu Ser Leu Gln Ser Pro
3900 3905 3910 3915
gat gtc atg atc tct cag gta aac tat gag ccc cta gtc cct tca gaa 11925
Asp Val Met Ile Ser Gln Val Asn Tyr Glu Pro Leu Val Pro Ser Glu
3920 3925 3930
cac tca tgc aca gaa gga ggt aaa att ttg ata gaa agt gca aat cca 11973
His Ser Cys Thr Glu Gly Gly Lys Ile Leu Ile Glu Ser Ala Asn Pro
3935 3940 3945
ctg gaa aat gca ggg caa gat tct gcg gtc aga att gag gaa ggc aag 12021
Leu Glu Asn Ala Gly Gln Asp Ser Ala Val Arg Ile Glu Glu Gly Lys
3950 3955 3960
tcc tta aga ttt cca cta gca ctt gaa gaa aag cag gta ctg ctc aaa 12069
Ser Leu Arg Phe Pro Leu Ala Leu Glu Glu Lys Gln Val Leu Leu Lys
3965 3970 3975
gaa gag cat tct gac aac gtg gtg atg ccc cca gac caa atc att gag 12117
Glu Glu His Ser Asp Asn Val Val Met Pro Pro Asp Gln Ile Ile Glu
3980 3985 3990 3995
tct aaa aga gag ccc gtg gca ata aag aaa gtg cag gag gta cag gga 12165
Ser Lys Arg Glu Pro Val Ala Ile Lys Lys Val Gln Glu Val Gln Gly
4000 4005 4010
agg gac ctt ctt tct aag gaa agc ttg ctt tct ggt att cca gaa gag 12213
Arg Asp Leu Leu Ser Lys Glu Ser Leu Leu Ser Gly Ile Pro Glu Glu
4015 4020 4025
cag aga tta aac ctg aaa att caa atc tgc cgg gct ttg caa gca gcc 12261
Gln Arg Leu Asn Leu Lys Ile Gln Ile Cys Arg Ala Leu Gln Ala Ala
4030 4035 4040
gtg gcc agc gag cag cca ggt ctt ttc tct gag tgg cta aga aat att 12309
Val Ala Ser Glu Gln Pro Gly Leu Phe Ser Glu Trp Leu Arg Asn Ile
4045 4050 4055
gaa aag gtg gag gtc gag gct gta aac atc acc caa gag ccc aga cac 12357
Glu Lys Val Glu Val Glu Ala Val Asn Ile Thr Gln Glu Pro Arg His
4060 4065 4070 4075
atc atg tgc atg tac ctt gtt act tcg gca aag tct gta aca gaa gaa 12405
Ile Met Cys Met Tyr Leu Val Thr Ser Ala Lys Ser Val Thr Glu Glu
4080 4085 4090
gta acc atc att att gaa gat gtt gat cct caa atg gct aac ctg aaa 12453
Val Thr Ile Ile Ile Glu Asp Val Asp Pro Gln Met Ala Asn Leu Lys
4095 4100 4105
atg gaa ctt agg gat gct ttg tgt gct att ata tat gag gaa ata gac 12501
Met Glu Leu Arg Asp Ala Leu Cys Ala Ile Ile Tyr Glu Glu Ile Asp
4110 4115 4120
atc cta aca gct gag ggt cct aga att cag caa gga gcc aaa aca agt 12549
Ile Leu Thr Ala Glu Gly Pro Arg Ile Gln Gln Gly Ala Lys Thr Ser
4125 4130 4135
ttg caa gaa gaa atg gat tct ttt tca ggt tca cag aag gtt gaa ccc 12597
Leu Gln Glu Glu Met Asp Ser Phe Ser Gly Ser Gln Lys Val Glu Pro
4140 4145 4150 4155
att act gaa cca gaa gtt gaa tct aaa tat ctg atc tca act gaa gag 12645
Ile Thr Glu Pro Glu Val Glu Ser Lys Tyr Leu Ile Ser Thr Glu Glu
4160 4165 4170
gtc agt tat ttt aac gtg caa agt agg gtt aaa tat ttg gat gcc aca 12693
Val Ser Tyr Phe Asn Val Gln Ser Arg Val Lys Tyr Leu Asp Ala Thr
4175 4180 4185
cct gtc act aaa ggg gtt gct tca gct gtt gtc tct gac gaa aaa caa 12741
Pro Val Thr Lys Gly Val Ala Ser Ala Val Val Ser Asp Glu Lys Gln
4190 4195 4200
gat gag agt ctg aaa cca tca gag gaa aaa gag gag tct tcc tct gaa 12789
Asp Glu Ser Leu Lys Pro Ser Glu Glu Lys Glu Glu Ser Ser Ser Glu
4205 4210 4215
agt ggt act gag gag gtt gct aca gta aag ata cag gaa gct gag ggt 12837
Ser Gly Thr Glu Glu Val Ala Thr Val Lys Ile Gln Glu Ala Glu Gly
4220 4225 4230 4235
ggc tta atc aaa gag gat ggc ccc atg ata cat aca cct tta gtg gac 12885
Gly Leu Ile Lys Glu Asp Gly Pro Met Ile His Thr Pro Leu Val Asp
4240 4245 4250
act gtt tct gag gaa ggt gat att gta cac ctc aca aca tcc ata aca 12933
Thr Val Ser Glu Glu Gly Asp Ile Val His Leu Thr Thr Ser Ile Thr
4255 4260 4265
aat gct aaa gag gtg aat tgg tat ttt gag aat aaa ctg gtg cct tca 12981
Asn Ala Lys Glu Val Asn Trp Tyr Phe Glu Asn Lys Leu Val Pro Ser
4270 4275 4280
gat gaa aag ttc aag tgt tta caa gat caa aat aca tat acg cta gtc 13029
Asp Glu Lys Phe Lys Cys Leu Gln Asp Gln Asn Thr Tyr Thr Leu Val
4285 4290 4295
atc gac aaa gta aat acc gaa gac cat caa gga gag tat gtc tgt gag 13077
Ile Asp Lys Val Asn Thr Glu Asp His Gln Gly Glu Tyr Val Cys Glu
4300 4305 4310 4315
gcc ttg aat gac agc gga aaa aca gca act tca gcc aaa ctc act gta 13125
Ala Leu Asn Asp Ser Gly Lys Thr Ala Thr Ser Ala Lys Leu Thr Val
4320 4325 4330
gta aaa aga gct gcc cca gtg atc aag agg aaa atc gaa ccc ctg gaa 13173
Val Lys Arg Ala Ala Pro Val Ile Lys Arg Lys Ile Glu Pro Leu Glu
4335 4340 4345
gta gca ctg ggc cac cta gcc aaa ttc acc tgt gag atc caa agt gct 13221
Val Ala Leu Gly His Leu Ala Lys Phe Thr Cys Glu Ile Gln Ser Ala
4350 4355 4360
ccc aat gtc cgg ttc cag tgg ttt aaa gct ggc cga gaa att tat gag 13269
Pro Asn Val Arg Phe Gln Trp Phe Lys Ala Gly Arg Glu Ile Tyr Glu
4365 4370 4375
agt gac aag tgt tct att cga tct tca aag tat atc tcc agc ctt gaa 13317
Ser Asp Lys Cys Ser Ile Arg Ser Ser Lys Tyr Ile Ser Ser Leu Glu
4380 4385 4390 4395
atc ctg aga acc cag gtg gtt gac tgc ggc gag tat aca tgc aaa gct 13365
Ile Leu Arg Thr Gln Val Val Asp Cys Gly Glu Tyr Thr Cys Lys Ala
4400 4405 4410
tcc aat gag tat ggc agt gtc agc tgt aca gcc aca cta act gtg aca 13413
Ser Asn Glu Tyr Gly Ser Val Ser Cys Thr Ala Thr Leu Thr Val Thr
4415 4420 4425
gtg cct gga ggt gaa aag aaa gtt cgc aaa tta ctt ccg gaa cgt aaa 13461
Val Pro Gly Gly Glu Lys Lys Val Arg Lys Leu Leu Pro Glu Arg Lys
4430 4435 4440
cct gaa cca aag gaa gaa gtt gtt ctg aaa agc gtt cta aga aaa aga 13509
Pro Glu Pro Lys Glu Glu Val Val Leu Lys Ser Val Leu Arg Lys Arg
4445 4450 4455
cct gaa gaa gaa gaa cct aaa gta gaa cct aaa aaa cta gaa aaa gtt 13557
Pro Glu Glu Glu Glu Pro Lys Val Glu Pro Lys Lys Leu Glu Lys Val
4460 4465 4470 4475
aaa aaa cct gca gta cca gaa cca cca cct cca aaa cct gtt gaa gag 13605
Lys Lys Pro Ala Val Pro Glu Pro Pro Pro Pro Lys Pro Val Glu Glu
4480 4485 4490
gtt gaa gta cct act gtt aca aaa agg gaa agg aag att cct gaa cca 13653
Val Glu Val Pro Thr Val Thr Lys Arg Glu Arg Lys Ile Pro Glu Pro
4495 4500 4505
aca aaa gtg cct gaa atc aag cca gca ata cct ctc cct gca cct gaa 13701
Thr Lys Val Pro Glu Ile Lys Pro Ala Ile Pro Leu Pro Ala Pro Glu
4510 4515 4520
ccg aaa cca aag ccc gaa gca gaa gtg aaa aca atc aaa cca cct cct 13749
Pro Lys Pro Lys Pro Glu Ala Glu Val Lys Thr Ile Lys Pro Pro Pro
4525 4530 4535
gtg gaa cct gaa cca acc ccc atc gct gcc cca gta aca gtg cca gtg 13797
Val Glu Pro Glu Pro Thr Pro Ile Ala Ala Pro Val Thr Val Pro Val
4540 4545 4550 4555
gtt gga aag aaa gca gaa gcc aaa gca cct aag gaa gag gct gcc aag 13845
Val Gly Lys Lys Ala Glu Ala Lys Ala Pro Lys Glu Glu Ala Ala Lys
4560 4565 4570
cca aaa ggt cct atc aaa ggt gta ccc aaa aag act cct tca cca ata 13893
Pro Lys Gly Pro Ile Lys Gly Val Pro Lys Lys Thr Pro Ser Pro Ile
4575 4580 4585
gaa gcc gaa agg aga aag tta agg cca gga agt ggt gga gag aaa cct 13941
Glu Ala Glu Arg Arg Lys Leu Arg Pro Gly Ser Gly Gly Glu Lys Pro
4590 4595 4600
cct gat gaa gcc ccg ttc acc tac cag cta aag gct gtg cca ctg aag 13989
Pro Asp Glu Ala Pro Phe Thr Tyr Gln Leu Lys Ala Val Pro Leu Lys
4605 4610 4615
ttt gtg aaa gaa atc aaa gac atc atc ttg aca gaa tca gag ttc gtt 14037
Phe Val Lys Glu Ile Lys Asp Ile Ile Leu Thr Glu Ser Glu Phe Val
4620 4625 4630 4635
ggc tct tca gca atc ttt gaa tgt ttg gtc tcc cct tcc act gca att 14085
Gly Ser Ser Ala Ile Phe Glu Cys Leu Val Ser Pro Ser Thr Ala Ile
4640 4645 4650
aca acc tgg atg aaa gac ggt agc aat atc cgt gag agt ccc aag cac 14133
Thr Thr Trp Met Lys Asp Gly Ser Asn Ile Arg Glu Ser Pro Lys His
4655 4660 4665
agg ttt att gca gat ggt aaa gac aga aag ctg cac atc att gat gtt 14181
Arg Phe Ile Ala Asp Gly Lys Asp Arg Lys Leu His Ile Ile Asp Val
4670 4675 4680
caa ctt tcc gat gct ggt gaa tac acc tgt gtt tta cgt ttg gga aac 14229
Gln Leu Ser Asp Ala Gly Glu Tyr Thr Cys Val Leu Arg Leu Gly Asn
4685 4690 4695
aaa gaa aag acc tcc acg gct aaa ctt gtt gta gaa gaa ctt cct gtg 14277
Lys Glu Lys Thr Ser Thr Ala Lys Leu Val Val Glu Glu Leu Pro Val
4700 4705 4710 4715
cgt ttt gta aaa aca ctg gaa gag gaa gtc aca gtg gtc aaa gga cag 14325
Arg Phe Val Lys Thr Leu Glu Glu Glu Val Thr Val Val Lys Gly Gln
4720 4725 4730
cca ttg tac ttg agc tgc gag tta aac aaa gag cgt gac gtg gtc tgg 14373
Pro Leu Tyr Leu Ser Cys Glu Leu Asn Lys Glu Arg Asp Val Val Trp
4735 4740 4745
agg aag gat ggc aag att gtg gtg gag aaa cct ggc cga att gtg cca 14421
Arg Lys Asp Gly Lys Ile Val Val Glu Lys Pro Gly Arg Ile Val Pro
4750 4755 4760
ggc gtc att ggc ttg atg cgg gct ctg acc atc aac gat gca gat gac 14469
Gly Val Ile Gly Leu Met Arg Ala Leu Thr Ile Asn Asp Ala Asp Asp
4765 4770 4775
aca gat gct gga aca tac aca gtt act gtg gaa aac gcc aac aac ctg 14517
Thr Asp Ala Gly Thr Tyr Thr Val Thr Val Glu Asn Ala Asn Asn Leu
4780 4785 4790 4795
gag tgt tca tct tgc gta aaa gta gta gaa gtc att aga gat tgg ctg 14565
Glu Cys Ser Ser Cys Val Lys Val Val Glu Val Ile Arg Asp Trp Leu
4800 4805 4810
gtg aaa cct ata cga gac cag cat gtg aaa ccc aag ggg aca gct att 14613
Val Lys Pro Ile Arg Asp Gln His Val Lys Pro Lys Gly Thr Ala Ile
4815 4820 4825
ttt gcc tgt gat ata gca aaa gat act cca aac att aag tgg ttc aaa 14661
Phe Ala Cys Asp Ile Ala Lys Asp Thr Pro Asn Ile Lys Trp Phe Lys
4830 4835 4840
gga tat gat gaa atc cct gcg gaa cca aat gat aag act gaa ata ctg 14709
Gly Tyr Asp Glu Ile Pro Ala Glu Pro Asn Asp Lys Thr Glu Ile Leu
4845 4850 4855
aga gat gga aat cat ctg tac ctc aaa att aag aat gct atg cca gaa 14757
Arg Asp Gly Asn His Leu Tyr Leu Lys Ile Lys Asn Ala Met Pro Glu
4860 4865 4870 4875
gat att gct gag tat gca gtg gaa att gaa gga aaa aga tac cct gca 14805
Asp Ile Ala Glu Tyr Ala Val Glu Ile Glu Gly Lys Arg Tyr Pro Ala
4880 4885 4890
aag ctg aca ctt gga gag cgt gaa gtt gaa ctg ctt aaa cca ata gag 14853
Lys Leu Thr Leu Gly Glu Arg Glu Val Glu Leu Leu Lys Pro Ile Glu
4895 4900 4905
gac gtt acc att tat gag aaa gaa agt gca agc ttt gat gca gaa atc 14901
Asp Val Thr Ile Tyr Glu Lys Glu Ser Ala Ser Phe Asp Ala Glu Ile
4910 4915 4920
tca gag gca gac att cct gga caa tgg aaa ctg aaa gga gaa ctt cta 14949
Ser Glu Ala Asp Ile Pro Gly Gln Trp Lys Leu Lys Gly Glu Leu Leu
4925 4930 4935
agg ccc tca cct act tgt gaa atc aaa gca gaa ggt gga aaa cgc ttc 14997
Arg Pro Ser Pro Thr Cys Glu Ile Lys Ala Glu Gly Gly Lys Arg Phe
4940 4945 4950 4955
tta act ttg cac aaa gtc aaa ctg gac caa gct ggt gaa gtc ctc tac 15045
Leu Thr Leu His Lys Val Lys Leu Asp Gln Ala Gly Glu Val Leu Tyr
4960 4965 4970
cag gcc ctt aat gca att aca act gcc att ttg aca gta aaa gaa atc 15093
Gln Ala Leu Asn Ala Ile Thr Thr Ala Ile Leu Thr Val Lys Glu Ile
4975 4980 4985
gaa ctt gac ttt gct gtg ccc ctg aag gat gtc act gtt cca gaa agg 15141
Glu Leu Asp Phe Ala Val Pro Leu Lys Asp Val Thr Val Pro Glu Arg
4990 4995 5000
cga cag gct cga ttc gaa tgt gtc ctc acc cga gag gca aat gtt ata 15189
Arg Gln Ala Arg Phe Glu Cys Val Leu Thr Arg Glu Ala Asn Val Ile
5005 5010 5015
tgg tcc aaa gga cct gat ata att aag tca tct gac aaa ttt gat atc 15237
Trp Ser Lys Gly Pro Asp Ile Ile Lys Ser Ser Asp Lys Phe Asp Ile
5020 5025 5030 5035
atc gct gat gga aag aaa cat att ctt gtt att aat gat tct caa ttt 15285
Ile Ala Asp Gly Lys Lys His Ile Leu Val Ile Asn Asp Ser Gln Phe
5040 5045 5050
gat gat gaa ggg gtc tat act gct gag gtg gag ggc aag aag acc tca 15333
Asp Asp Glu Gly Val Tyr Thr Ala Glu Val Glu Gly Lys Lys Thr Ser
5055 5060 5065
gct cgg ttg ttt gtc aca ggt ata aga ctg aaa ttc atg tca cct ctt 15381
Ala Arg Leu Phe Val Thr Gly Ile Arg Leu Lys Phe Met Ser Pro Leu
5070 5075 5080
gaa gat caa aca gta aaa gaa ggt gaa aca gca act ttt gtt tgt gaa 15429
Glu Asp Gln Thr Val Lys Glu Gly Glu Thr Ala Thr Phe Val Cys Glu
5085 5090 5095
ctt tct cat gaa aaa atg cat gta gtc tgg ttc aaa aat gat gcc aaa 15477
Leu Ser His Glu Lys Met His Val Val Trp Phe Lys Asn Asp Ala Lys
5100 5105 5110 5115
ctc cat aca agc aga aca gta ctc atc tct tct gag ggc aag act cac 15525
Leu His Thr Ser Arg Thr Val Leu Ile Ser Ser Glu Gly Lys Thr His
5120 5125 5130
aaa ttg gaa atg aaa gaa gtg aca ttg gat gat ata tct cag ata aaa 15573
Lys Leu Glu Met Lys Glu Val Thr Leu Asp Asp Ile Ser Gln Ile Lys
5135 5140 5145
gct caa gtc aag gag ctg agc tcc aca gca cag ctg aag gtc tta gag 15621
Ala Gln Val Lys Glu Leu Ser Ser Thr Ala Gln Leu Lys Val Leu Glu
5150 5155 5160
gcc gat ccc tac ttc act gtg aaa tta cat gac aaa act gca gtg gag 15669
Ala Asp Pro Tyr Phe Thr Val Lys Leu His Asp Lys Thr Ala Val Glu
5165 5170 5175
aag gat gag att act ttg aag tgt gaa gtg agc aaa gat gta cca gtg 15717
Lys Asp Glu Ile Thr Leu Lys Cys Glu Val Ser Lys Asp Val Pro Val
5180 5185 5190 5195
aaa tgg ttc aaa gat ggt gaa gag att gtc cct tca ccc aaa tat tct 15765
Lys Trp Phe Lys Asp Gly Glu Glu Ile Val Pro Ser Pro Lys Tyr Ser
5200 5205 5210
atc aag gca gat ggc ctg cgc cgc atc tta aaa atc aaa aag gcg gac 15813
Ile Lys Ala Asp Gly Leu Arg Arg Ile Leu Lys Ile Lys Lys Ala Asp
5215 5220 5225
ctt aaa gat aaa ggc gaa tat gtg tgt gac tgt ggc aca gac aag acc 15861
Leu Lys Asp Lys Gly Glu Tyr Val Cys Asp Cys Gly Thr Asp Lys Thr
5230 5235 5240
aag gca aat gtt act gtt gag gct cga cta ata gaa gtg gaa aag cct 15909
Lys Ala Asn Val Thr Val Glu Ala Arg Leu Ile Glu Val Glu Lys Pro
5245 5250 5255
ctg tac gga gta gag gtg ttt gtt ggt gaa aca gcc cac ttt gaa att 15957
Leu Tyr Gly Val Glu Val Phe Val Gly Glu Thr Ala His Phe Glu Ile
5260 5265 5270 5275
gaa ctt tct gaa cct gat gtt cac ggc cag tgg aag ctg aaa gga cag 16005
Glu Leu Ser Glu Pro Asp Val His Gly Gln Trp Lys Leu Lys Gly Gln
5280 5285 5290
cct ttg aca gct tcc cct gac tgt gaa atc att gag gat gga aag aag 16053
Pro Leu Thr Ala Ser Pro Asp Cys Glu Ile Ile Glu Asp Gly Lys Lys
5295 5300 5305
cat att ctg atc ctt cat aac tgt cag ctg ggt atg aca gga gag gtt 16101
His Ile Leu Ile Leu His Asn Cys Gln Leu Gly Met Thr Gly Glu Val
5310 5315 5320
tcc ttc cag gct gct aat gcc aaa tct gca gcc aat ctg aaa gtg aaa 16149
Ser Phe Gln Ala Ala Asn Ala Lys Ser Ala Ala Asn Leu Lys Val Lys
5325 5330 5335
gaa ttg cct ctt atc ttc atc aca cct ctc agt gat gtt aaa gtc ttc 16197
Glu Leu Pro Leu Ile Phe Ile Thr Pro Leu Ser Asp Val Lys Val Phe
5340 5345 5350 5355
gag aaa gat gag gct aag ttt gag tgt gaa gta tcc agg gag ccc aaa 16245
Glu Lys Asp Glu Ala Lys Phe Glu Cys Glu Val Ser Arg Glu Pro Lys
5360 5365 5370
aca ttc cgt tgg cta aaa gga acc cag gaa atc aca ggt gat gac aga 16293
Thr Phe Arg Trp Leu Lys Gly Thr Gln Glu Ile Thr Gly Asp Asp Arg
5375 5380 5385
ttt gag ctt ata aag gat ggc act aag cat tca atg gtg atc aag tca 16341
Phe Glu Leu Ile Lys Asp Gly Thr Lys His Ser Met Val Ile Lys Ser
5390 5395 5400
gct gct ttt gaa gat gaa gca aaa tac atg ttt gaa gct gaa gat aag 16389
Ala Ala Phe Glu Asp Glu Ala Lys Tyr Met Phe Glu Ala Glu Asp Lys
5405 5410 5415
cac aca agt ggc aaa ctg atc att gaa gga atc cgg ctc aaa ttc ctc 16437
His Thr Ser Gly Lys Leu Ile Ile Glu Gly Ile Arg Leu Lys Phe Leu
5420 5425 5430 5435
acc cct ctc aaa gat gta act gcc aaa gag aag gaa agt gct gta ttt 16485
Thr Pro Leu Lys Asp Val Thr Ala Lys Glu Lys Glu Ser Ala Val Phe
5440 5445 5450
act gtg gag tta tct cat gat aac atc cga gtt aaa tgg ttc aag aat 16533
Thr Val Glu Leu Ser His Asp Asn Ile Arg Val Lys Trp Phe Lys Asn
5455 5460 5465
gac cag cgc cta cac acc acc agg tcg gtc tca atg caa gac gaa ggg 16581
Asp Gln Arg Leu His Thr Thr Arg Ser Val Ser Met Gln Asp Glu Gly
5470 5475 5480
aaa act cat tcg atc aca ttc aaa gac ctg tct att gat gac acc tcc 16629
Lys Thr His Ser Ile Thr Phe Lys Asp Leu Ser Ile Asp Asp Thr Ser
5485 5490 5495
caa att aga gta gaa gct atg ggg atg agt tca gaa gct aaa ctc act 16677
Gln Ile Arg Val Glu Ala Met Gly Met Ser Ser Glu Ala Lys Leu Thr
5500 5505 5510 5515
gtg ctt gag gga gac cca tat ttt aca gga aaa ctt caa gat tat act 16725
Val Leu Glu Gly Asp Pro Tyr Phe Thr Gly Lys Leu Gln Asp Tyr Thr
5520 5525 5530
ggt gta gag aaa gat gaa gtt att cta cag tgt gaa att agc aaa gca 16773
Gly Val Glu Lys Asp Glu Val Ile Leu Gln Cys Glu Ile Ser Lys Ala
5535 5540 5545
gat gca cca gtg aaa tgg ttt aag gat ggg aag gaa ata aag cca tcc 16821
Asp Ala Pro Val Lys Trp Phe Lys Asp Gly Lys Glu Ile Lys Pro Ser
5550 5555 5560
aaa aat gct gtt att aag aca gat ggc aag aaa cgc atg cta atc cta 16869
Lys Asn Ala Val Ile Lys Thr Asp Gly Lys Lys Arg Met Leu Ile Leu
5565 5570 5575
aag aaa gcc ttg aaa tca gat att gga cag tac acc tgt gac tgt ggg 16917
Lys Lys Ala Leu Lys Ser Asp Ile Gly Gln Tyr Thr Cys Asp Cys Gly
5580 5585 5590 5595
aca gat aag acc tca gga aaa ctt gac att gag gat cgg gaa att aaa 16965
Thr Asp Lys Thr Ser Gly Lys Leu Asp Ile Glu Asp Arg Glu Ile Lys
5600 5605 5610
ctg gtg cga ccc ctg cac agt gtg gag gtg atg gag act gag aca gca 17013
Leu Val Arg Pro Leu His Ser Val Glu Val Met Glu Thr Glu Thr Ala
5615 5620 5625
cgc ttt gaa acc gaa atc tct gaa gat gat atc cac gcc aac tgg aaa 17061
Arg Phe Glu Thr Glu Ile Ser Glu Asp Asp Ile His Ala Asn Trp Lys
5630 5635 5640
ctc aag gga gag gcc cta ctc caa aca cct gat tgt gaa att aag gaa 17109
Leu Lys Gly Glu Ala Leu Leu Gln Thr Pro Asp Cys Glu Ile Lys Glu
5645 5650 5655
gaa ggc aaa ata cac tcc ctt gtt ttg cac aac tgt cgc ctg gac cag 17157
Glu Gly Lys Ile His Ser Leu Val Leu His Asn Cys Arg Leu Asp Gln
5660 5665 5670 5675
acg ggt ggg gtg gat ttc caa gct gcc aat gtt aaa tct agt gcc cac 17205
Thr Gly Gly Val Asp Phe Gln Ala Ala Asn Val Lys Ser Ser Ala His
5680 5685 5690
ctc cga gtt aag cca cga gta att ggt ctt ctg agg cct tta aag gat 17253
Leu Arg Val Lys Pro Arg Val Ile Gly Leu Leu Arg Pro Leu Lys Asp
5695 5700 5705
gtc acc gtg act gca ggg gaa aca gcc acc ttc gac tgc gag ctc tcc 17301
Val Thr Val Thr Ala Gly Glu Thr Ala Thr Phe Asp Cys Glu Leu Ser
5710 5715 5720
tac gaa gat atc cca gtg gaa tgg tat ctc aaa ggg aag aaa cta gag 17349
Tyr Glu Asp Ile Pro Val Glu Trp Tyr Leu Lys Gly Lys Lys Leu Glu
5725 5730 5735
ccc agc gat aag gtg gtc cca cgt tca gaa gga aaa gtt cat aca ctt 17397
Pro Ser Asp Lys Val Val Pro Arg Ser Glu Gly Lys Val His Thr Leu
5740 5745 5750 5755
act ctg agg gat gta aag tta gaa gat gct ggg gaa gtc caa cta aca 17445
Thr Leu Arg Asp Val Lys Leu Glu Asp Ala Gly Glu Val Gln Leu Thr
5760 5765 5770
gca aaa gat ttc aaa act cac gcc aac ctc ttt gtg aaa gaa ccc cca 17493
Ala Lys Asp Phe Lys Thr His Ala Asn Leu Phe Val Lys Glu Pro Pro
5775 5780 5785
gtt gaa ttc act aag cct ctt gag gac cag acg gtc gaa gag gga gcc 17541
Val Glu Phe Thr Lys Pro Leu Glu Asp Gln Thr Val Glu Glu Gly Ala
5790 5795 5800
act gca gtg ctg gag tgt gaa gtc tcc aga gaa aat gct aag gtg aaa 17589
Thr Ala Val Leu Glu Cys Glu Val Ser Arg Glu Asn Ala Lys Val Lys
5805 5810 5815
tgg ttc aaa aat ggg aca gaa atc ctc aaa agc aag aag tat gaa att 17637
Trp Phe Lys Asn Gly Thr Glu Ile Leu Lys Ser Lys Lys Tyr Glu Ile
5820 5825 5830 5835
gtt gct gat ggc agg gtc aga aaa ctt gtt ata cat gac tgt acc cca 17685
Val Ala Asp Gly Arg Val Arg Lys Leu Val Ile His Asp Cys Thr Pro
5840 5845 5850
gag gat att aaa aca tac act tgt gat gct aag gat ttt aag act tcc 17733
Glu Asp Ile Lys Thr Tyr Thr Cys Asp Ala Lys Asp Phe Lys Thr Ser
5855 5860 5865
tgt aac ctg aat gtc gtg cct cct cat gtg gaa ttc tta aga cca ctc 17781
Cys Asn Leu Asn Val Val Pro Pro His Val Glu Phe Leu Arg Pro Leu
5870 5875 5880
acc gac ctt caa gtt aga gaa aaa gaa atg gct cga ttt gag tgt gaa 17829
Thr Asp Leu Gln Val Arg Glu Lys Glu Met Ala Arg Phe Glu Cys Glu
5885 5890 5895
ctt tcc cga gaa aat gct aag gtt aag tgg ttt aaa gat ggt gct gaa 17877
Leu Ser Arg Glu Asn Ala Lys Val Lys Trp Phe Lys Asp Gly Ala Glu
5900 5905 5910 5915
att aaa aag ggc aaa aaa tat gac atc ata tcc aag gga gca gtg cgc 17925
Ile Lys Lys Gly Lys Lys Tyr Asp Ile Ile Ser Lys Gly Ala Val Arg
5920 5925 5930
att ctt gtc atc aac aaa tgt cta ctg gat gat gaa gct gaa tat tcc 17973
Ile Leu Val Ile Asn Lys Cys Leu Leu Asp Asp Glu Ala Glu Tyr Ser
5935 5940 5945
tgt gaa gta agg aca gcg aga act tct ggc atg ctg aca gtt ctg gaa 18021
Cys Glu Val Arg Thr Ala Arg Thr Ser Gly Met Leu Thr Val Leu Glu
5950 5955 5960
gaa gaa gct gtc ttt acc aaa aat ctt gcc aac att gaa gtt agt gaa 18069
Glu Glu Ala Val Phe Thr Lys Asn Leu Ala Asn Ile Glu Val Ser Glu
5965 5970 5975
aca gac act ata aaa ctg gtt tgt gaa gtc tcc aaa cct ggc gca gaa 18117
Thr Asp Thr Ile Lys Leu Val Cys Glu Val Ser Lys Pro Gly Ala Glu
5980 5985 5990 5995
gtg att tgg tat aaa ggg gat gag gag atc att gaa aca gga aga tat 18165
Val Ile Trp Tyr Lys Gly Asp Glu Glu Ile Ile Glu Thr Gly Arg Tyr
6000 6005 6010
gaa ata ctg act gaa gga cgg aag aga atc ctg gtc att cag aac gct 18213
Glu Ile Leu Thr Glu Gly Arg Lys Arg Ile Leu Val Ile Gln Asn Ala
6015 6020 6025
cac ctt gag gat gct ggc aac tac aac tgt cga ctc cca agc tct cga 18261
His Leu Glu Asp Ala Gly Asn Tyr Asn Cys Arg Leu Pro Ser Ser Arg
6030 6035 6040
acc gat ggc aaa gtc aaa gta cat gaa ctg gct gct gaa ttt atc tca 18309
Thr Asp Gly Lys Val Lys Val His Glu Leu Ala Ala Glu Phe Ile Ser
6045 6050 6055
aag cct caa aac ctt gaa ata ctt gaa gga gaa aag gct gaa ttt gtc 18357
Lys Pro Gln Asn Leu Glu Ile Leu Glu Gly Glu Lys Ala Glu Phe Val
6060 6065 6070 6075
tgc tct ata tca aaa gaa agc ttt cca gtc cag tgg aag agg gat gat 18405
Cys Ser Ile Ser Lys Glu Ser Phe Pro Val Gln Trp Lys Arg Asp Asp
6080 6085 6090
aag aca ctt gaa tct gga gat aaa tat gac gtt att gct gat ggt aaa 18453
Lys Thr Leu Glu Ser Gly Asp Lys Tyr Asp Val Ile Ala Asp Gly Lys
6095 6100 6105
aag agg gtc cta gtt gtg aaa gat gcc aca tta caa gat atg ggc act 18501
Lys Arg Val Leu Val Val Lys Asp Ala Thr Leu Gln Asp Met Gly Thr
6110 6115 6120
tac gtt gtc atg gta ggg gcc gcc aga gca gca gct cac ttg aca gtc 18549
Tyr Val Val Met Val Gly Ala Ala Arg Ala Ala Ala His Leu Thr Val
6125 6130 6135
att gaa aaa ctc agg atc gta gtt cct ctt aag gac acc cgg gtg aag 18597
Ile Glu Lys Leu Arg Ile Val Val Pro Leu Lys Asp Thr Arg Val Lys
6140 6145 6150 6155
gaa caa cag gaa gtt gtc ttc aac tgt gaa gtc aat act gaa ggt gcc 18645
Glu Gln Gln Glu Val Val Phe Asn Cys Glu Val Asn Thr Glu Gly Ala
6160 6165 6170
aaa gcc aaa tgg ttc aga aat gaa gaa gct ata ttt gat agt tca aaa 18693
Lys Ala Lys Trp Phe Arg Asn Glu Glu Ala Ile Phe Asp Ser Ser Lys
6175 6180 6185
tac atc att ctc caa aaa gac cta gtc tac acc ctc aga att aga gat 18741
Tyr Ile Ile Leu Gln Lys Asp Leu Val Tyr Thr Leu Arg Ile Arg Asp
6190 6195 6200
gca cac tta gat gac caa gcc aac tat aat gtg tct ttg acc aat cac 18789
Ala His Leu Asp Asp Gln Ala Asn Tyr Asn Val Ser Leu Thr Asn His
6205 6210 6215
aga ggt gaa aat gtt aaa agt gca gcc aat cta ata gta gaa gag gaa 18837
Arg Gly Glu Asn Val Lys Ser Ala Ala Asn Leu Ile Val Glu Glu Glu
6220 6225 6230 6235
gac ctt agg att gtt gag cct ctt aaa gat att gaa aca atg gag aag 18885
Asp Leu Arg Ile Val Glu Pro Leu Lys Asp Ile Glu Thr Met Glu Lys
6240 6245 6250
aaa tct gtc aca ttc tgg tgc aag gtg aat cgt ctc aat gta aca ctg 18933
Lys Ser Val Thr Phe Trp Cys Lys Val Asn Arg Leu Asn Val Thr Leu
6255 6260 6265
aag tgg acc aaa aat ggt gaa gaa gtg cct ttt gac aac cgt gtc tca 18981
Lys Trp Thr Lys Asn Gly Glu Glu Val Pro Phe Asp Asn Arg Val Ser
6270 6275 6280
tac aga gtt gat aag tac aag cac atg tta acc att aaa gac tgt ggc 19029
Tyr Arg Val Asp Lys Tyr Lys His Met Leu Thr Ile Lys Asp Cys Gly
6285 6290 6295
ttc cca gat gaa ggt gaa tac att gtc act gct gga caa gat aaa tct 19077
Phe Pro Asp Glu Gly Glu Tyr Ile Val Thr Ala Gly Gln Asp Lys Ser
6300 6305 6310 6315
gtt gct gag ctt ctc atc ata gaa gcc ccg aca gaa ttt gtg gaa cac 19125
Val Ala Glu Leu Leu Ile Ile Glu Ala Pro Thr Glu Phe Val Glu His
6320 6325 6330
ttg gaa gat cag aca gtc act gag ttc gat gac gct gtc ttc tcc tgc 19173
Leu Glu Asp Gln Thr Val Thr Glu Phe Asp Asp Ala Val Phe Ser Cys
6335 6340 6345
cag ctc tcc aga gag aaa gcc aat gta aaa tgg tac aga aat ggg aga 19221
Gln Leu Ser Arg Glu Lys Ala Asn Val Lys Trp Tyr Arg Asn Gly Arg
6350 6355 6360
gaa atc aaa gaa ggc aaa aaa tac aaa ttt gaa aaa gat gga agt ata 19269
Glu Ile Lys Glu Gly Lys Lys Tyr Lys Phe Glu Lys Asp Gly Ser Ile
6365 6370 6375
cac aga ctc att ata aaa gat tgc agg ctg gat gat gag tgt gaa tat 19317
His Arg Leu Ile Ile Lys Asp Cys Arg Leu Asp Asp Glu Cys Glu Tyr
6380 6385 6390 6395
gct tgc ggg gta gaa gac agg aag tct cgt gct aga ctt ttt gtg gaa 19365
Ala Cys Gly Val Glu Asp Arg Lys Ser Arg Ala Arg Leu Phe Val Glu
6400 6405 6410
gaa att cct gtt gag atc atc agg cct cca caa gat att ctt gaa gcc 19413
Glu Ile Pro Val Glu Ile Ile Arg Pro Pro Gln Asp Ile Leu Glu Ala
6415 6420 6425
cct ggt gct gat gtt gtc ttt tta gca gaa ctc aat aaa gat aag gtg 19461
Pro Gly Ala Asp Val Val Phe Leu Ala Glu Leu Asn Lys Asp Lys Val
6430 6435 6440
gaa gtc caa tgg cta aga aat aac atg gtt gtt gtc cag ggt gat aaa 19509
Glu Val Gln Trp Leu Arg Asn Asn Met Val Val Val Gln Gly Asp Lys
6445 6450 6455
cac cag atg atg agt gaa gga aag ata cat cga cta cag att tgt gat 19557
His Gln Met Met Ser Glu Gly Lys Ile His Arg Leu Gln Ile Cys Asp
6460 6465 6470 6475
att aag ccc cgt gac cag ggt gaa tac aga ttt att gcc aaa gac aaa 19605
Ile Lys Pro Arg Asp Gln Gly Glu Tyr Arg Phe Ile Ala Lys Asp Lys
6480 6485 6490
gaa gcc aga gct aag ctt gaa ctg gca gct gca cca aaa atc aag aca 19653
Glu Ala Arg Ala Lys Leu Glu Leu Ala Ala Ala Pro Lys Ile Lys Thr
6495 6500 6505
gct gac caa gac ctt gtg gtt gat gtt ggc aag cct ctg aca atg gtg 19701
Ala Asp Gln Asp Leu Val Val Asp Val Gly Lys Pro Leu Thr Met Val
6510 6515 6520
gtg cca tat gat gcc tac ccc aaa gca gaa gct gaa tgg ttt aaa gaa 19749
Val Pro Tyr Asp Ala Tyr Pro Lys Ala Glu Ala Glu Trp Phe Lys Glu
6525 6530 6535
aat gaa cct tta tct aca aaa acc att gat act acg gct gaa caa act 19797
Asn Glu Pro Leu Ser Thr Lys Thr Ile Asp Thr Thr Ala Glu Gln Thr
6540 6545 6550 6555
tct ttc aga att tta gaa gcc aag aaa gga gac aaa ggg agg tat aaa 19845
Ser Phe Arg Ile Leu Glu Ala Lys Lys Gly Asp Lys Gly Arg Tyr Lys
6560 6565 6570
att gtg ctt cag aac aaa cat gga aaa gca gaa gga ttc atc aat tta 19893
Ile Val Leu Gln Asn Lys His Gly Lys Ala Glu Gly Phe Ile Asn Leu
6575 6580 6585
aaa gtt att gat gtt cct ggg cca gta cgt aac tta gaa gtg aca gaa 19941
Lys Val Ile Asp Val Pro Gly Pro Val Arg Asn Leu Glu Val Thr Glu
6590 6595 6600
aca ttt gat ggt gaa gtg agc ctt gct tgg gaa gaa cct tta act gat 19989
Thr Phe Asp Gly Glu Val Ser Leu Ala Trp Glu Glu Pro Leu Thr Asp
6605 6610 6615
ggt gga agc aaa atc ata ggt tac gtt gtt gaa aga cgt gac att aag 20037
Gly Gly Ser Lys Ile Ile Gly Tyr Val Val Glu Arg Arg Asp Ile Lys
6620 6625 6630 6635
aga aag acc tgg gtt ctg gcc aca gac cgt gca gag agt tgt gag ttt 20085
Arg Lys Thr Trp Val Leu Ala Thr Asp Arg Ala Glu Ser Cys Glu Phe
6640 6645 6650
act gtc act ggt cta cag aaa gga gga gtt gag tac cta ttc cgt gtg 20133
Thr Val Thr Gly Leu Gln Lys Gly Gly Val Glu Tyr Leu Phe Arg Val
6655 6660 6665
agt gca aga aac aga gtt ggc act ggt gag cca gta gaa act gac aat 20181
Ser Ala Arg Asn Arg Val Gly Thr Gly Glu Pro Val Glu Thr Asp Asn
6670 6675 6680
cct gta gaa gca agg agt aaa tat gat gtt cca ggc cct cct ttg aat 20229
Pro Val Glu Ala Arg Ser Lys Tyr Asp Val Pro Gly Pro Pro Leu Asn
6685 6690 6695
gta acc atc act gat gtg aat cga ttt ggt gtc tca ctg aca tgg gaa 20277
Val Thr Ile Thr Asp Val Asn Arg Phe Gly Val Ser Leu Thr Trp Glu
6700 6705 6710 6715
cca cca gag tat gat gga ggt gct gag atc aca aac tac gtc att gaa 20325
Pro Pro Glu Tyr Asp Gly Gly Ala Glu Ile Thr Asn Tyr Val Ile Glu
6720 6725 6730
tta aga gac aag act tct atc agg tgg gat act gcc atg act gtg aga 20373
Leu Arg Asp Lys Thr Ser Ile Arg Trp Asp Thr Ala Met Thr Val Arg
6735 6740 6745
gct gaa gac ctg tct gca act gtt act gat gtg gta gaa gga cag gag 20421
Ala Glu Asp Leu Ser Ala Thr Val Thr Asp Val Val Glu Gly Gln Glu
6750 6755 6760
tac agt ttc cga gtg aga gcc caa aat cga att gga gtt gga aaa cca 20469
Tyr Ser Phe Arg Val Arg Ala Gln Asn Arg Ile Gly Val Gly Lys Pro
6765 6770 6775
agt gca gcc aca ccc ttc gtc aaa gtt gct gat cca att gag aga cca 20517
Ser Ala Ala Thr Pro Phe Val Lys Val Ala Asp Pro Ile Glu Arg Pro
6780 6785 6790 6795
agt cct cct gta aac cta act tcc tca gat cag act cag tca tca gtt 20565
Ser Pro Pro Val Asn Leu Thr Ser Ser Asp Gln Thr Gln Ser Ser Val
6800 6805 6810
cag ctc aaa tgg gaa cct cct ctg aaa gat gga gga agc cca ata tta 20613
Gln Leu Lys Trp Glu Pro Pro Leu Lys Asp Gly Gly Ser Pro Ile Leu
6815 6820 6825
ggc tat ata att gag cga tgc gaa gaa gga aaa gat aat tgg att cgt 20661
Gly Tyr Ile Ile Glu Arg Cys Glu Glu Gly Lys Asp Asn Trp Ile Arg
6830 6835 6840
tgc aat atg aaa ctt gtc cct gaa ctg act tac aag gtt acc gga ttg 20709
Cys Asn Met Lys Leu Val Pro Glu Leu Thr Tyr Lys Val Thr Gly Leu
6845 6850 6855
gaa aaa gga aat aaa tat tta tat aga gta tct gca gaa aat aaa gct 20757
Glu Lys Gly Asn Lys Tyr Leu Tyr Arg Val Ser Ala Glu Asn Lys Ala
6860 6865 6870 6875
ggt gtt tca gat cca tct gaa att ctt ggt cct ctc acc gct gac gat 20805
Gly Val Ser Asp Pro Ser Glu Ile Leu Gly Pro Leu Thr Ala Asp Asp
6880 6885 6890
gca ttt gtt gaa cca aca atg gat tta agt gca ttt aaa gat ggt ctg 20853
Ala Phe Val Glu Pro Thr Met Asp Leu Ser Ala Phe Lys Asp Gly Leu
6895 6900 6905
gaa gtt att gtc cca aat cct atc acg atc ctg gtt cca agt aca ggc 20901
Glu Val Ile Val Pro Asn Pro Ile Thr Ile Leu Val Pro Ser Thr Gly
6910 6915 6920
tat cca agg cca act gca acc tgg tgt ttt gga gat aaa gta cta gaa 20949
Tyr Pro Arg Pro Thr Ala Thr Trp Cys Phe Gly Asp Lys Val Leu Glu
6925 6930 6935
aca ggg gac cgg gtg aaa atg aag acc ttg tct gcc tat gcc gaa ctt 20997
Thr Gly Asp Arg Val Lys Met Lys Thr Leu Ser Ala Tyr Ala Glu Leu
6940 6945 6950 6955
gtc att tct cca agt gaa cgt tca gac aag ggc att tat aca ctg aaa 21045
Val Ile Ser Pro Ser Glu Arg Ser Asp Lys Gly Ile Tyr Thr Leu Lys
6960 6965 6970
tta gaa aac cgt gtg aaa aca att tct ggg gaa att gat gtc aat gta 21093
Leu Glu Asn Arg Val Lys Thr Ile Ser Gly Glu Ile Asp Val Asn Val
6975 6980 6985
att gct cgc cca agt gca ccc aaa gaa ttg aaa ttt ggt gat ata acc 21141
Ile Ala Arg Pro Ser Ala Pro Lys Glu Leu Lys Phe Gly Asp Ile Thr
6990 6995 7000
aag gac tca gta cat ttg act tgg gaa cca cct gat gat gat gga gga 21189
Lys Asp Ser Val His Leu Thr Trp Glu Pro Pro Asp Asp Asp Gly Gly
7005 7010 7015
agt ccg tta act gga tac gtt gtt gaa aaa cga gaa gtc agc cgg aaa 21237
Ser Pro Leu Thr Gly Tyr Val Val Glu Lys Arg Glu Val Ser Arg Lys
7020 7025 7030 7035
aca tgg act aaa gtt atg gac ttt gtg act gat cta gaa ttc aca gtt 21285
Thr Trp Thr Lys Val Met Asp Phe Val Thr Asp Leu Glu Phe Thr Val
7040 7045 7050
cct gat ctt gtt caa gga aaa gag tac tta ttt aaa gtt tgt gct cgt 21333
Pro Asp Leu Val Gln Gly Lys Glu Tyr Leu Phe Lys Val Cys Ala Arg
7055 7060 7065
aac aaa tgt ggc cct gga gaa cct gca tat gtt gat gaa cct gta aat 21381
Asn Lys Cys Gly Pro Gly Glu Pro Ala Tyr Val Asp Glu Pro Val Asn
7070 7075 7080
atg tca act cct gca acg gta cct gac cca cca gag aat gtt aaa tgg 21429
Met Ser Thr Pro Ala Thr Val Pro Asp Pro Pro Glu Asn Val Lys Trp
7085 7090 7095
aga gat cga aca gcc aat agc atc ttc tta aca tgg gat cca cct aaa 21477
Arg Asp Arg Thr Ala Asn Ser Ile Phe Leu Thr Trp Asp Pro Pro Lys
7100 7105 7110 7115
aat gat ggt ggt tca cgc atc aaa gga tat ata gtt gaa aga tgt cca 21525
Asn Asp Gly Gly Ser Arg Ile Lys Gly Tyr Ile Val Glu Arg Cys Pro
7120 7125 7130
cgt ggt tct gat aaa tgg gtt gcc tgt gga gaa cct gtt gca gaa aca 21573
Arg Gly Ser Asp Lys Trp Val Ala Cys Gly Glu Pro Val Ala Glu Thr
7135 7140 7145
aaa atg gaa gtg aca ggt ctt gag gaa ggc aaa tgg tat gcc tac cgc 21621
Lys Met Glu Val Thr Gly Leu Glu Glu Gly Lys Trp Tyr Ala Tyr Arg
7150 7155 7160
gtg aag acc tta aac agg cag ggt gct agc aaa cca agc aga ccc aca 21669
Val Lys Thr Leu Asn Arg Gln Gly Ala Ser Lys Pro Ser Arg Pro Thr
7165 7170 7175
gag gaa atc cag gct gtg gac aca caa gag gcc cca gaa atc ttc ctc 21717
Glu Glu Ile Gln Ala Val Asp Thr Gln Glu Ala Pro Glu Ile Phe Leu
7180 7185 7190 7195
gat gtg aag ctc ctt gct ggt ctc act gta aaa gct ggg acc aag att 21765
Asp Val Lys Leu Leu Ala Gly Leu Thr Val Lys Ala Gly Thr Lys Ile
7200 7205 7210
gaa ctt cct gcc acc gta acc gga aaa cct gaa cct aaa ata act tgg 21813
Glu Leu Pro Ala Thr Val Thr Gly Lys Pro Glu Pro Lys Ile Thr Trp
7215 7220 7225
aca aag gct gat atg att ctg aag cag gac aaa aga att acc att gaa 21861
Thr Lys Ala Asp Met Ile Leu Lys Gln Asp Lys Arg Ile Thr Ile Glu
7230 7235 7240
aat gtc cct aag aaa tcc aca gtg act att gtt gat agt aag aga agt 21909
Asn Val Pro Lys Lys Ser Thr Val Thr Ile Val Asp Ser Lys Arg Ser
7245 7250 7255
gac act ggc aca tat atc att gag gct gtg aat gtg tgt ggc cgg gcc 21957
Asp Thr Gly Thr Tyr Ile Ile Glu Ala Val Asn Val Cys Gly Arg Ala
7260 7265 7270 7275
act gct gtg gtg gaa gtg aac gtc tta gat aaa ccc gga cca cca gct 22005
Thr Ala Val Val Glu Val Asn Val Leu Asp Lys Pro Gly Pro Pro Ala
7280 7285 7290
gcc ttt gac atc aca gat gta acc aat gag tca tgt ctt cta aca tgg 22053
Ala Phe Asp Ile Thr Asp Val Thr Asn Glu Ser Cys Leu Leu Thr Trp
7295 7300 7305
aac cca cca cgc gat gat ggt gga tct aag atc aca aac tat gtt gtg 22101
Asn Pro Pro Arg Asp Asp Gly Gly Ser Lys Ile Thr Asn Tyr Val Val
7310 7315 7320
gag aga cga gca act gat agt gaa gtg tgg cac aag ctc tca tcc acc 22149
Glu Arg Arg Ala Thr Asp Ser Glu Val Trp His Lys Leu Ser Ser Thr
7325 7330 7335
gtc aag gat aca aac ttc aag gcc acc aaa tta atc ccc aat aaa gag 22197
Val Lys Asp Thr Asn Phe Lys Ala Thr Lys Leu Ile Pro Asn Lys Glu
7340 7345 7350 7355
tac atc ttc aga gtt gct gca gaa aac atg tat ggt gct ggt gaa cca 22245
Tyr Ile Phe Arg Val Ala Ala Glu Asn Met Tyr Gly Ala Gly Glu Pro
7360 7365 7370
gtt cag gcc tct cca ata aca gcc aaa tat cag ttt gat cca cct ggt 22293
Val Gln Ala Ser Pro Ile Thr Ala Lys Tyr Gln Phe Asp Pro Pro Gly
7375 7380 7385
cct cca act cgc cta gaa cct tct gat atc act aaa gac gca gtg act 22341
Pro Pro Thr Arg Leu Glu Pro Ser Asp Ile Thr Lys Asp Ala Val Thr
7390 7395 7400
ctc aca tgg tgt gag cca gat gat gat ggt ggc agc cca atc aca gga 22389
Leu Thr Trp Cys Glu Pro Asp Asp Asp Gly Gly Ser Pro Ile Thr Gly
7405 7410 7415
tac tgg gtt gaa aga ctg gat cct gat aca gat aaa tgg gtt aga tgc 22437
Tyr Trp Val Glu Arg Leu Asp Pro Asp Thr Asp Lys Trp Val Arg Cys
7420 7425 7430 7435
aat aag atg cca gta aag gac aca aca tac aga gtg aaa ggt ctc act 22485
Asn Lys Met Pro Val Lys Asp Thr Thr Tyr Arg Val Lys Gly Leu Thr
7440 7445 7450
aat aag aaa aaa tac aga ttc cgt gtg ttg gct gaa aat ctt gct gga 22533
Asn Lys Lys Lys Tyr Arg Phe Arg Val Leu Ala Glu Asn Leu Ala Gly
7455 7460 7465
cct gga aaa cca agc aaa tca act gaa cca atc tta ata aag gat ccc 22581
Pro Gly Lys Pro Ser Lys Ser Thr Glu Pro Ile Leu Ile Lys Asp Pro
7470 7475 7480
ata gat cct cca tgg ccc cct gga aaa cca act gta aaa gat gta ggc 22629
Ile Asp Pro Pro Trp Pro Pro Gly Lys Pro Thr Val Lys Asp Val Gly
7485 7490 7495
aaa aca tca gta agg ttg aat tgg aca aaa cca gaa cat gat gga ggt 22677
Lys Thr Ser Val Arg Leu Asn Trp Thr Lys Pro Glu His Asp Gly Gly
7500 7505 7510 7515
gca aag att gag tct tat gtc att gaa atg ctg aag act gga aca gat 22725
Ala Lys Ile Glu Ser Tyr Val Ile Glu Met Leu Lys Thr Gly Thr Asp
7520 7525 7530
gag tgg gtc aga gtg gcg gaa ggg gtt ccc acc act cag cac ttg ctc 22773
Glu Trp Val Arg Val Ala Glu Gly Val Pro Thr Thr Gln His Leu Leu
7535 7540 7545
cca ggg ctc atg gaa gga cag gaa tac tca ttc cga gtt aga gct gtg 22821
Pro Gly Leu Met Glu Gly Gln Glu Tyr Ser Phe Arg Val Arg Ala Val
7550 7555 7560
aat aag gct ggg gaa agt gaa ccc agt gaa ccc agt gac cct gtg ctt 22869
Asn Lys Ala Gly Glu Ser Glu Pro Ser Glu Pro Ser Asp Pro Val Leu
7565 7570 7575
tgc cgg gag aag cta tat cct cca tca cca cca cgc tgg ctt gaa gtt 22917
Cys Arg Glu Lys Leu Tyr Pro Pro Ser Pro Pro Arg Trp Leu Glu Val
7580 7585 7590 7595
att aat atc aca aaa aat aca gca gac cta aaa tgg aca gtt cct gag 22965
Ile Asn Ile Thr Lys Asn Thr Ala Asp Leu Lys Trp Thr Val Pro Glu
7600 7605 7610
aaa gat gga ggg tcc ccc atc acc aac tac att gtg gaa aag aga gac 23013
Lys Asp Gly Gly Ser Pro Ile Thr Asn Tyr Ile Val Glu Lys Arg Asp
7615 7620 7625
gtc agg cga aaa ggc tgg caa aca gtg gat acc act gtc aag gac acc 23061
Val Arg Arg Lys Gly Trp Gln Thr Val Asp Thr Thr Val Lys Asp Thr
7630 7635 7640
aag tgc aca gtc acc cca ctg act gag ggc tct tta tat gtg ttc cga 23109
Lys Cys Thr Val Thr Pro Leu Thr Glu Gly Ser Leu Tyr Val Phe Arg
7645 7650 7655
gtt gct gca gaa aat gct ata gga caa agc gac tac acc gaa att gag 23157
Val Ala Ala Glu Asn Ala Ile Gly Gln Ser Asp Tyr Thr Glu Ile Glu
7660 7665 7670 7675
gac tct gtg ctg gcc aaa gac acc ttt acc act cct gga cca ccc tac 23205
Asp Ser Val Leu Ala Lys Asp Thr Phe Thr Thr Pro Gly Pro Pro Tyr
7680 7685 7690
gcc ctg gca gtg gtt gat gtg aca aaa cga cat gtt gac cta aag tgg 23253
Ala Leu Ala Val Val Asp Val Thr Lys Arg His Val Asp Leu Lys Trp
7695 7700 7705
gag cca cct aaa aat gat ggt gga aga cca ata cag aga tat gtc att 23301
Glu Pro Pro Lys Asn Asp Gly Gly Arg Pro Ile Gln Arg Tyr Val Ile
7710 7715 7720
gag aag aaa gaa agg tta ggt acc cgt tgg gtg aaa gct gga aag act 23349
Glu Lys Lys Glu Arg Leu Gly Thr Arg Trp Val Lys Ala Gly Lys Thr
7725 7730 7735
gca gga cct gac tgt aac ttc aga gta act gat gtc atc gaa gga aca 23397
Ala Gly Pro Asp Cys Asn Phe Arg Val Thr Asp Val Ile Glu Gly Thr
7740 7745 7750 7755
gag gtc cag ttt cag gtt cgg gct gaa aat gaa gct gga gtt ggc cac 23445
Glu Val Gln Phe Gln Val Arg Ala Glu Asn Glu Ala Gly Val Gly His
7760 7765 7770
cca agt gaa ccc aca gaa atc cta tcc att gaa gat cca aca agt cct 23493
Pro Ser Glu Pro Thr Glu Ile Leu Ser Ile Glu Asp Pro Thr Ser Pro
7775 7780 7785
ccc tca cca ccc ctt gac cta cat gtg act gat gct ggg aga aaa cac 23541
Pro Ser Pro Pro Leu Asp Leu His Val Thr Asp Ala Gly Arg Lys His
7790 7795 7800
att gcc att gct tgg aag cct cca gag aaa aat ggt gga agt cct atc 23589
Ile Ala Ile Ala Trp Lys Pro Pro Glu Lys Asn Gly Gly Ser Pro Ile
7805 7810 7815
ata gga tac cat gtt gaa atg tgt cca gta ggc act gag aaa tgg atg 23637
Ile Gly Tyr His Val Glu Met Cys Pro Val Gly Thr Glu Lys Trp Met
7820 7825 7830 7835
aga gtt aat tct cgc cca ata aag gac ttg aaa ttc aag gtt gaa gaa 23685
Arg Val Asn Ser Arg Pro Ile Lys Asp Leu Lys Phe Lys Val Glu Glu
7840 7845 7850
ggt gtt gtt cct gac aaa gaa tat gtc ctg aga gtg aga gca gtc aat 23733
Gly Val Val Pro Asp Lys Glu Tyr Val Leu Arg Val Arg Ala Val Asn
7855 7860 7865
gct att ggt gtc agc gag cca tct gaa atc tct gaa aat gtg gtt gcc 23781
Ala Ile Gly Val Ser Glu Pro Ser Glu Ile Ser Glu Asn Val Val Ala
7870 7875 7880
aaa gac cca gac tgc aag cca aca att gac ctg gag act cat gac att 23829
Lys Asp Pro Asp Cys Lys Pro Thr Ile Asp Leu Glu Thr His Asp Ile
7885 7890 7895
att gtt att gaa ggt gaa aag tta agc att cct gtt ccc ttc aga gct 23877
Ile Val Ile Glu Gly Glu Lys Leu Ser Ile Pro Val Pro Phe Arg Ala
7900 7905 7910 7915
gtc cca gtt cca act gtt agt tgg cat aaa gat ggc aaa gaa gtt aaa 23925
Val Pro Val Pro Thr Val Ser Trp His Lys Asp Gly Lys Glu Val Lys
7920 7925 7930
gca agt gat aga tta aca atg aag aat gat cac atc tct gca cac ctt 23973
Ala Ser Asp Arg Leu Thr Met Lys Asn Asp His Ile Ser Ala His Leu
7935 7940 7945
gaa gtt ccc aag agt gtc cgt gca gat gcc gga att tat acc att aca 24021
Glu Val Pro Lys Ser Val Arg Ala Asp Ala Gly Ile Tyr Thr Ile Thr
7950 7955 7960
ctg gag aat aag ctc ggc tca gca aca gcc tca atc aat gtc aaa gtc 24069
Leu Glu Asn Lys Leu Gly Ser Ala Thr Ala Ser Ile Asn Val Lys Val
7965 7970 7975
ata ggc cta cct gga cca tgc aaa gat att aaa gca agt gac att acc 24117
Ile Gly Leu Pro Gly Pro Cys Lys Asp Ile Lys Ala Ser Asp Ile Thr
7980 7985 7990 7995
aag agt tct tgt aag tta act tgg gaa cct cca gaa ttt gat ggt gga 24165
Lys Ser Ser Cys Lys Leu Thr Trp Glu Pro Pro Glu Phe Asp Gly Gly
8000 8005 8010
acc cca att ctt cat tat gtc ctg gag cgc aga gaa gct ggg agg aga 24213
Thr Pro Ile Leu His Tyr Val Leu Glu Arg Arg Glu Ala Gly Arg Arg
8015 8020 8025
aca tat ata cca gtc atg tct ggt gag aac aaa ctg tca tgg act gtg 24261
Thr Tyr Ile Pro Val Met Ser Gly Glu Asn Lys Leu Ser Trp Thr Val
8030 8035 8040
aag gat ctc ata cca aat ggt gaa tac ttc ttc cgt gtt aaa gca gtc 24309
Lys Asp Leu Ile Pro Asn Gly Glu Tyr Phe Phe Arg Val Lys Ala Val
8045 8050 8055
aac aag gtt ggt gga gga gaa tat att gaa ctg aaa aat cca gtc att 24357
Asn Lys Val Gly Gly Gly Glu Tyr Ile Glu Leu Lys Asn Pro Val Ile
8060 8065 8070 8075
gct caa gat cca aag caa ccc cct gat cca cct gta gat gta gag gtt 24405
Ala Gln Asp Pro Lys Gln Pro Pro Asp Pro Pro Val Asp Val Glu Val
8080 8085 8090
cat aat cct aca gcg gag gca atg act att aca tgg aag cca cct ttg 24453
His Asn Pro Thr Ala Glu Ala Met Thr Ile Thr Trp Lys Pro Pro Leu
8095 8100 8105
tat gat gga ggg agc aag ata atg ggc tac atc ata gag aag att gct 24501
Tyr Asp Gly Gly Ser Lys Ile Met Gly Tyr Ile Ile Glu Lys Ile Ala
8110 8115 8120
aag ggt gaa gaa agg tgg aag aga tgc aat gaa cac ctg gta cca atc 24549
Lys Gly Glu Glu Arg Trp Lys Arg Cys Asn Glu His Leu Val Pro Ile
8125 8130 8135
ctg acc tat aca gca aaa gga ctt gaa gag ggg aaa gag tac caa ttc 24597
Leu Thr Tyr Thr Ala Lys Gly Leu Glu Glu Gly Lys Glu Tyr Gln Phe
8140 8145 8150 8155
cgt gtg cga gca gag aac gcc gcg ggt att agt gaa cct tct cgg gct 24645
Arg Val Arg Ala Glu Asn Ala Ala Gly Ile Ser Glu Pro Ser Arg Ala
8160 8165 8170
act cct cca acc aaa gct gta gat ccc att gat gcc ccc aaa gtc att 24693
Thr Pro Pro Thr Lys Ala Val Asp Pro Ile Asp Ala Pro Lys Val Ile
8175 8180 8185
ctg aga aca agc cta gaa gtg aaa cga ggt gat gaa ata gca ctt gat 24741
Leu Arg Thr Ser Leu Glu Val Lys Arg Gly Asp Glu Ile Ala Leu Asp
8190 8195 8200
gca agt att tct gga tca cct tac cca act att aca tgg ata aag gat 24789
Ala Ser Ile Ser Gly Ser Pro Tyr Pro Thr Ile Thr Trp Ile Lys Asp
8205 8210 8215
gaa aat gtt att gta cca gag gaa att aag aag cgt gca gca ccc ttg 24837
Glu Asn Val Ile Val Pro Glu Glu Ile Lys Lys Arg Ala Ala Pro Leu
8220 8225 8230 8235
gtt agg aga agg aag ggt gaa gtt caa gaa gaa gaa cca ttt gtc ctg 24885
Val Arg Arg Arg Lys Gly Glu Val Gln Glu Glu Glu Pro Phe Val Leu
8240 8245 8250
cct ctg aca cag cgt ttg agt att gac aac agc aaa aag gga gaa tct 24933
Pro Leu Thr Gln Arg Leu Ser Ile Asp Asn Ser Lys Lys Gly Glu Ser
8255 8260 8265
cag cta cgc gtc cga gat tct ctc cga cct gac cat ggt ctg tat atg 24981
Gln Leu Arg Val Arg Asp Ser Leu Arg Pro Asp His Gly Leu Tyr Met
8270 8275 8280
atc aaa gtt gaa aat gac cac ggt att gca aaa gct cct tgt act gtc 25029
Ile Lys Val Glu Asn Asp His Gly Ile Ala Lys Ala Pro Cys Thr Val
8285 8290 8295
agt gtg tta gat aca ccg gga cca cca atc aac ttt gta ttt gaa gat 25077
Ser Val Leu Asp Thr Pro Gly Pro Pro Ile Asn Phe Val Phe Glu Asp
8300 8305 8310 8315
atc aga aag acc tca gtc ctt tgt aaa tgg gaa cca ccc ctt gat gat 25125
Ile Arg Lys Thr Ser Val Leu Cys Lys Trp Glu Pro Pro Leu Asp Asp
8320 8325 8330
ggt ggc agt gaa atc ata aac tac act ttg gaa aag aaa gac aag aca 25173
Gly Gly Ser Glu Ile Ile Asn Tyr Thr Leu Glu Lys Lys Asp Lys Thr
8335 8340 8345
aaa ccc gac tca gaa tgg att gtt gtc act tca aca ctt aga cat tgc 25221
Lys Pro Asp Ser Glu Trp Ile Val Val Thr Ser Thr Leu Arg His Cys
8350 8355 8360
aaa tat tca gta aca aaa ctg att gaa gga aaa gag tac ctc ttc cgt 25269
Lys Tyr Ser Val Thr Lys Leu Ile Glu Gly Lys Glu Tyr Leu Phe Arg
8365 8370 8375
gta aga gct gaa aac aga ttt ggg cca ggt cca cca tgt gtt tca aag 25317
Val Arg Ala Glu Asn Arg Phe Gly Pro Gly Pro Pro Cys Val Ser Lys
8380 8385 8390 8395
cca ctt gtg gct aaa gat cca ttt gga cca cct gat gca cca gat aag 25365
Pro Leu Val Ala Lys Asp Pro Phe Gly Pro Pro Asp Ala Pro Asp Lys
8400 8405 8410
ccc att gtg gaa gat gtt acc agc aac agt atg cta gtg aaa tgg aat 25413
Pro Ile Val Glu Asp Val Thr Ser Asn Ser Met Leu Val Lys Trp Asn
8415 8420 8425
gaa cca aaa gat aat gga agc ccc att ttg ggt tac tgg ctt gaa aaa 25461
Glu Pro Lys Asp Asn Gly Ser Pro Ile Leu Gly Tyr Trp Leu Glu Lys
8430 8435 8440
cgt gaa gtt aac agt aca cat tgg tct cgt gtc aac aaa agc ctt ctg 25509
Arg Glu Val Asn Ser Thr His Trp Ser Arg Val Asn Lys Ser Leu Leu
8445 8450 8455
aat gcc ttg aaa gcc aat gta gat ggc tta tta gaa gga ctc acc tat 25557
Asn Ala Leu Lys Ala Asn Val Asp Gly Leu Leu Glu Gly Leu Thr Tyr
8460 8465 8470 8475
gtc ttc aga gta tgt gct gaa aat gca gct gga cct gga aag ttc agt 25605
Val Phe Arg Val Cys Ala Glu Asn Ala Ala Gly Pro Gly Lys Phe Ser
8480 8485 8490
cca cct tca gat ccc aaa aca gca cat gat cca atc tct cct cct ggg 25653
Pro Pro Ser Asp Pro Lys Thr Ala His Asp Pro Ile Ser Pro Pro Gly
8495 8500 8505
cca cct atc cca aga gtc act gac aca agc tct aca act att gaa cta 25701
Pro Pro Ile Pro Arg Val Thr Asp Thr Ser Ser Thr Thr Ile Glu Leu
8510 8515 8520
gaa tgg gaa ccc cca gct ttc aat ggt ggt ggg gaa att gtt ggc tat 25749
Glu Trp Glu Pro Pro Ala Phe Asn Gly Gly Gly Glu Ile Val Gly Tyr
8525 8530 8535
ttt gtt gat aag cag ttg gtt ggc aca aat aaa tgg tca cgc tgc aca 25797
Phe Val Asp Lys Gln Leu Val Gly Thr Asn Lys Trp Ser Arg Cys Thr
8540 8545 8550 8555
gag aag atg atc aag gtc cgt cag tac acc gtc aaa gaa atc cga gag 25845
Glu Lys Met Ile Lys Val Arg Gln Tyr Thr Val Lys Glu Ile Arg Glu
8560 8565 8570
ggt gct gat tac aaa ctt cgg gtg agt gct gtc aat gcc gca ggg gaa 25893
Gly Ala Asp Tyr Lys Leu Arg Val Ser Ala Val Asn Ala Ala Gly Glu
8575 8580 8585
gga ccg cct gga gaa aca caa cct gtt act gtg gct gaa cca caa gag 25941
Gly Pro Pro Gly Glu Thr Gln Pro Val Thr Val Ala Glu Pro Gln Glu
8590 8595 8600
cct cca gct gtg gaa ctg gat gtt tct gtc aag ggt gga ata caa ata 25989
Pro Pro Ala Val Glu Leu Asp Val Ser Val Lys Gly Gly Ile Gln Ile
8605 8610 8615
atg gct ggg aag act ctt aga att cca gct gtg gtg act ggt cgc cct 26037
Met Ala Gly Lys Thr Leu Arg Ile Pro Ala Val Val Thr Gly Arg Pro
8620 8625 8630 8635
gta cct aca aaa gta tgg acc aaa gaa gaa ggg gag ctg gat aaa gac 26085
Val Pro Thr Lys Val Trp Thr Lys Glu Glu Gly Glu Leu Asp Lys Asp
8640 8645 8650
cgt gtt gta ata gac aac gtt gga acc aaa tct gaa cta att atc aag 26133
Arg Val Val Ile Asp Asn Val Gly Thr Lys Ser Glu Leu Ile Ile Lys
8655 8660 8665
gat gca ctg cga aaa gac cat ggc aga tat gtg att aca gct aca aat 26181
Asp Ala Leu Arg Lys Asp His Gly Arg Tyr Val Ile Thr Ala Thr Asn
8670 8675 8680
agc tgt ggt tcc aaa ttt gca gca gcc agg gta gaa gtt ttt gat gtc 26229
Ser Cys Gly Ser Lys Phe Ala Ala Ala Arg Val Glu Val Phe Asp Val
8685 8690 8695
cct ggt cca gtt ctt gac tta aaa cct gtt gta aca aac aga aaa atg 26277
Pro Gly Pro Val Leu Asp Leu Lys Pro Val Val Thr Asn Arg Lys Met
8700 8705 8710 8715
tgt cta ctt aac tgg tct gat cca gaa gat gat gga gga agt gaa ata 26325
Cys Leu Leu Asn Trp Ser Asp Pro Glu Asp Asp Gly Gly Ser Glu Ile
8720 8725 8730
aca ggc ttt atc att gaa aga aaa gat gcc aag atg cat act tgg aga 26373
Thr Gly Phe Ile Ile Glu Arg Lys Asp Ala Lys Met His Thr Trp Arg
8735 8740 8745
caa cca ata gag act gag aga tct aaa tgt gac atc aca ggt ctg ctt 26421
Gln Pro Ile Glu Thr Glu Arg Ser Lys Cys Asp Ile Thr Gly Leu Leu
8750 8755 8760
gag gga caa gaa tat aag ttc cgt gtt att gcc aag aac aag ttt ggc 26469
Glu Gly Gln Glu Tyr Lys Phe Arg Val Ile Ala Lys Asn Lys Phe Gly
8765 8770 8775
tgt ggc cct cct gtt gaa ata gga cca att ctt gca gtt gat cca cta 26517
Cys Gly Pro Pro Val Glu Ile Gly Pro Ile Leu Ala Val Asp Pro Leu
8780 8785 8790 8795
ggt cct cca aca tct cca gag agg ctc aca tac act gaa aga caa agg 26565
Gly Pro Pro Thr Ser Pro Glu Arg Leu Thr Tyr Thr Glu Arg Gln Arg
8800 8805 8810
tcc act atc aca ctt gac tgg aaa gag ccc cgc agt aat ggt ggc agt 26613
Ser Thr Ile Thr Leu Asp Trp Lys Glu Pro Arg Ser Asn Gly Gly Ser
8815 8820 8825
ccc atc caa gga tat atc att gaa aaa cgg cgt cat gac aaa cct gac 26661
Pro Ile Gln Gly Tyr Ile Ile Glu Lys Arg Arg His Asp Lys Pro Asp
8830 8835 8840
ttt gaa aga gtt aac aag cga ctc tgc cca acc aca tct ttt ctg gtt 26709
Phe Glu Arg Val Asn Lys Arg Leu Cys Pro Thr Thr Ser Phe Leu Val
8845 8850 8855
gaa aat ctt gat gaa cac caa atg tat gag ttc cgt gtc aaa gct gtc 26757
Glu Asn Leu Asp Glu His Gln Met Tyr Glu Phe Arg Val Lys Ala Val
8860 8865 8870 8875
aat gaa att ggt gaa agt gaa cca tcc cta cct ctt aat gta gtc ata 26805
Asn Glu Ile Gly Glu Ser Glu Pro Ser Leu Pro Leu Asn Val Val Ile
8880 8885 8890
caa gat gat gaa gtg cct cca act att aag ttg cgt ctg agt gtt cga 26853
Gln Asp Asp Glu Val Pro Pro Thr Ile Lys Leu Arg Leu Ser Val Arg
8895 8900 8905
gga gac act atc aaa gtt aag gca gga gag cct gtc cac atc cct gca 26901
Gly Asp Thr Ile Lys Val Lys Ala Gly Glu Pro Val His Ile Pro Ala
8910 8915 8920
gat gtg aca ggc ctt cca atg cct aag att gaa tgg tcc aaa aat gaa 26949
Asp Val Thr Gly Leu Pro Met Pro Lys Ile Glu Trp Ser Lys Asn Glu
8925 8930 8935
act gta att gaa aaa ccc act gat gca ctt cag ata acc aag gaa gag 26997
Thr Val Ile Glu Lys Pro Thr Asp Ala Leu Gln Ile Thr Lys Glu Glu
8940 8945 8950 8955
gta tcc cga agt gag gca aaa act gag ctt agc att ccc aaa gcg gtc 27045
Val Ser Arg Ser Glu Ala Lys Thr Glu Leu Ser Ile Pro Lys Ala Val
8960 8965 8970
cgg gag gac aaa ggc act tac aca gtt act gct tcc aat cgc ctt ggc 27093
Arg Glu Asp Lys Gly Thr Tyr Thr Val Thr Ala Ser Asn Arg Leu Gly
8975 8980 8985
tca gtg ttc cga aat gtt cac gtt gaa gta tat gac cgc cca tcc cca 27141
Ser Val Phe Arg Asn Val His Val Glu Val Tyr Asp Arg Pro Ser Pro
8990 8995 9000
cca aga aat ctt gct gtt act gac att aaa gct gaa tct tgc tac ttg 27189
Pro Arg Asn Leu Ala Val Thr Asp Ile Lys Ala Glu Ser Cys Tyr Leu
9005 9010 9015
aca tgg gat gcc cct ctt gat aat ggt ggc agt gaa atc acc cat tat 27237
Thr Trp Asp Ala Pro Leu Asp Asn Gly Gly Ser Glu Ile Thr His Tyr
9020 9025 9030 9035
gtt att gac aaa cgt gat gca agt agg aag aaa gca gaa tgg gag gaa 27285
Val Ile Asp Lys Arg Asp Ala Ser Arg Lys Lys Ala Glu Trp Glu Glu
9040 9045 9050
gtc acc aac act gct gta gag aaa aga tat ggg atc tgg aaa ctt atc 27333
Val Thr Asn Thr Ala Val Glu Lys Arg Tyr Gly Ile Trp Lys Leu Ile
9055 9060 9065
ccc aat ggt cag tat gag ttc cga gtc agg gca gtg aat aaa tat gga 27381
Pro Asn Gly Gln Tyr Glu Phe Arg Val Arg Ala Val Asn Lys Tyr Gly
9070 9075 9080
atc agt gat gag tgc aaa tca gat aaa gta gtc att caa gat cct tat 27429
Ile Ser Asp Glu Cys Lys Ser Asp Lys Val Val Ile Gln Asp Pro Tyr
9085 9090 9095
cgc ctt cct gga cct cca gga aaa cca aaa gtt ttg gca cgc acc aaa 27477
Arg Leu Pro Gly Pro Pro Gly Lys Pro Lys Val Leu Ala Arg Thr Lys
9100 9105 9110 9115
gga tca atg cta gtg agc tgg act cct cct ttg gac aat ggt ggc tct 27525
Gly Ser Met Leu Val Ser Trp Thr Pro Pro Leu Asp Asn Gly Gly Ser
9120 9125 9130
cca att act ggc tac tgg ctg gag aaa aga gaa gag gga agt cct tat 27573
Pro Ile Thr Gly Tyr Trp Leu Glu Lys Arg Glu Glu Gly Ser Pro Tyr
9135 9140 9145
tgg tca cgt gtt agc cga gca cca ata acc aaa gtg gga ttg aaa ggc 27621
Trp Ser Arg Val Ser Arg Ala Pro Ile Thr Lys Val Gly Leu Lys Gly
9150 9155 9160
gtg gaa ttt aat gtt cct cgt ttg ctt gaa ggc gtt aaa tac cag ttc 27669
Val Glu Phe Asn Val Pro Arg Leu Leu Glu Gly Val Lys Tyr Gln Phe
9165 9170 9175
aga gcc atg gca ata aat gct gca gga att ggt cct ccc agt gaa cca 27717
Arg Ala Met Ala Ile Asn Ala Ala Gly Ile Gly Pro Pro Ser Glu Pro
9180 9185 9190 9195
tca gat cca gag gtt gca gga gat ccc ata ttt cca ccg ggg cca cct 27765
Ser Asp Pro Glu Val Ala Gly Asp Pro Ile Phe Pro Pro Gly Pro Pro
9200 9205 9210
tct tgc cca gaa gtt aaa gat aaa acg aag tca agc atc tca cta gga 27813
Ser Cys Pro Glu Val Lys Asp Lys Thr Lys Ser Ser Ile Ser Leu Gly
9215 9220 9225
tgg aaa cct cca gcc aaa gat ggt ggc agc cca atc aaa gga tac att 27861
Trp Lys Pro Pro Ala Lys Asp Gly Gly Ser Pro Ile Lys Gly Tyr Ile
9230 9235 9240
gta gaa atg caa gaa gaa ggt act act gac tgg aaa aga gta aat gaa 27909
Val Glu Met Gln Glu Glu Gly Thr Thr Asp Trp Lys Arg Val Asn Glu
9245 9250 9255
cca gac aaa ctt ata act acc tgt gaa tgt gtg gtg cct aat ctg aaa 27957
Pro Asp Lys Leu Ile Thr Thr Cys Glu Cys Val Val Pro Asn Leu Lys
9260 9265 9270 9275
gag ctc agg aag tac aga ttc aga gtg aaa gct gtc aat gaa gct ggt 28005
Glu Leu Arg Lys Tyr Arg Phe Arg Val Lys Ala Val Asn Glu Ala Gly
9280 9285 9290
gaa tct gaa cca agt gat aca act ggg gag atc cct gcc act gat att 28053
Glu Ser Glu Pro Ser Asp Thr Thr Gly Glu Ile Pro Ala Thr Asp Ile
9295 9300 9305
caa gag gaa cca gaa gtt ttc att gac att gga gca cag gac tgt ctg 28101
Gln Glu Glu Pro Glu Val Phe Ile Asp Ile Gly Ala Gln Asp Cys Leu
9310 9315 9320
gtt tgt aaa gct ggc tca cag att agg att cct gct gtc atc aag gga 28149
Val Cys Lys Ala Gly Ser Gln Ile Arg Ile Pro Ala Val Ile Lys Gly
9325 9330 9335
cgc cca aca cca aaa tca tct tgg gaa ttt gat gga aag gca aag aaa 28197
Arg Pro Thr Pro Lys Ser Ser Trp Glu Phe Asp Gly Lys Ala Lys Lys
9340 9345 9350 9355
gca atg aag gat gga gtt cat gac ata ccc gaa gat gca cag ctg gag 28245
Ala Met Lys Asp Gly Val His Asp Ile Pro Glu Asp Ala Gln Leu Glu
9360 9365 9370
act gct gaa aac tcc tca gta att att att ccg gag tgt aaa cga tct 28293
Thr Ala Glu Asn Ser Ser Val Ile Ile Ile Pro Glu Cys Lys Arg Ser
9375 9380 9385
cat aca ggc aaa tac agc atc aca gcc aag aat aaa gca gga caa aag 28341
His Thr Gly Lys Tyr Ser Ile Thr Ala Lys Asn Lys Ala Gly Gln Lys
9390 9395 9400
act gca aat tgc aga gtt aaa gtc atg gat gta cca ggc cca ccc aaa 28389
Thr Ala Asn Cys Arg Val Lys Val Met Asp Val Pro Gly Pro Pro Lys
9405 9410 9415
gat ctg aaa gtc agt gat atc aca agg ggt agt tgc aga ctt tca tgg 28437
Asp Leu Lys Val Ser Asp Ile Thr Arg Gly Ser Cys Arg Leu Ser Trp
9420 9425 9430 9435
aag atg cca gac gac gat gga gga gac agg atc aaa ggc tat gtt att 28485
Lys Met Pro Asp Asp Asp Gly Gly Asp Arg Ile Lys Gly Tyr Val Ile
9440 9445 9450
gag aag agg act att gat gga aaa gcc tgg acc aaa gtc aat cca gac 28533
Glu Lys Arg Thr Ile Asp Gly Lys Ala Trp Thr Lys Val Asn Pro Asp
9455 9460 9465
tgt gga agc acc aca ttt gta gtg cct gat ctc ctc tct gaa cag caa 28581
Cys Gly Ser Thr Thr Phe Val Val Pro Asp Leu Leu Ser Glu Gln Gln
9470 9475 9480
tat ttc ttc cgt gtg cga gca gaa aac cgt ttt ggt att ggc cca cct 28629
Tyr Phe Phe Arg Val Arg Ala Glu Asn Arg Phe Gly Ile Gly Pro Pro
9485 9490 9495
gtg gaa acc att cag agg acc act gcc aga gat ccg ata tat cct cct 28677
Val Glu Thr Ile Gln Arg Thr Thr Ala Arg Asp Pro Ile Tyr Pro Pro
9500 9505 9510 9515
gat cct cct att aaa ctc aag att ggc ctc atc aca aag aac aca gtg 28725
Asp Pro Pro Ile Lys Leu Lys Ile Gly Leu Ile Thr Lys Asn Thr Val
9520 9525 9530
cat ctg tca tgg aaa ccc ccg aag aat gat ggg ggc tcc cct gtt acc 28773
His Leu Ser Trp Lys Pro Pro Lys Asn Asp Gly Gly Ser Pro Val Thr
9535 9540 9545
cac tat att gtt gag tgc ctt gca tgg gac cct act ggg aca aag aaa 28821
His Tyr Ile Val Glu Cys Leu Ala Trp Asp Pro Thr Gly Thr Lys Lys
9550 9555 9560
gaa gcc tgg agg cag tgc aat aag cgt gat gtg gaa gaa ctg caa ttt 28869
Glu Ala Trp Arg Gln Cys Asn Lys Arg Asp Val Glu Glu Leu Gln Phe
9565 9570 9575
act gtt gaa gac cta gta gaa ggt ggg gaa tat gaa ttc cga gtc aaa 28917
Thr Val Glu Asp Leu Val Glu Gly Gly Glu Tyr Glu Phe Arg Val Lys
9580 9585 9590 9595
gct gtc aat gct gca gga gtc agc aag cct tca gcc act gtt ggc ccc 28965
Ala Val Asn Ala Ala Gly Val Ser Lys Pro Ser Ala Thr Val Gly Pro
9600 9605 9610
tgt gac tgt caa aga cca gac atg cca cca tca att gat cta aaa gaa 29013
Cys Asp Cys Gln Arg Pro Asp Met Pro Pro Ser Ile Asp Leu Lys Glu
9615 9620 9625
ttc atg gag gtt gaa gaa gga acc aat gtt aac att gtg gcc aaa att 29061
Phe Met Glu Val Glu Glu Gly Thr Asn Val Asn Ile Val Ala Lys Ile
9630 9635 9640
aaa ggt gtg cca ttc ccg aca cta acc tgg ttt aaa gct cct cca aag 29109
Lys Gly Val Pro Phe Pro Thr Leu Thr Trp Phe Lys Ala Pro Pro Lys
9645 9650 9655
aag cct gat aac aaa gaa cct gtt ctc tat gac acc cat gtc aac aaa 29157
Lys Pro Asp Asn Lys Glu Pro Val Leu Tyr Asp Thr His Val Asn Lys
9660 9665 9670 9675
ctg gtg gta gat gat act tgc act tta gtt att ccg cag tct cgc agg 29205
Leu Val Val Asp Asp Thr Cys Thr Leu Val Ile Pro Gln Ser Arg Arg
9680 9685 9690
agt gac act ggc tta tat acc atc aca gct gta aat aat ctg gga aca 29253
Ser Asp Thr Gly Leu Tyr Thr Ile Thr Ala Val Asn Asn Leu Gly Thr
9695 9700 9705
gca tca aag gag atg aga ctg aat gtc ctg ggt cgt cct ggc cct cca 29301
Ala Ser Lys Glu Met Arg Leu Asn Val Leu Gly Arg Pro Gly Pro Pro
9710 9715 9720
gtg gga ccc ata aaa ttt gaa tct gtt tca gca gat caa atg aca cta 29349
Val Gly Pro Ile Lys Phe Glu Ser Val Ser Ala Asp Gln Met Thr Leu
9725 9730 9735
tct tgg ttt cca cct aaa gat gat ggt ggg tct aag att aca aac tat 29397
Ser Trp Phe Pro Pro Lys Asp Asp Gly Gly Ser Lys Ile Thr Asn Tyr
9740 9745 9750 9755
gta att gag aaa aga gaa gct aac agg aag aca tgg gtc cat gtc tcc 29445
Val Ile Glu Lys Arg Glu Ala Asn Arg Lys Thr Trp Val His Val Ser
9760 9765 9770
agt gaa cct aag gag tgc acg tac acg att ccc aaa ttg cta gaa ggc 29493
Ser Glu Pro Lys Glu Cys Thr Tyr Thr Ile Pro Lys Leu Leu Glu Gly
9775 9780 9785
cat gaa tat gta ttc cga atc atg gcc cag aat aaa tat ggc att gga 29541
His Glu Tyr Val Phe Arg Ile Met Ala Gln Asn Lys Tyr Gly Ile Gly
9790 9795 9800
gaa cct ctt gac agt gaa cct gaa aca gca aga aac ctc ttc tct gtc 29589
Glu Pro Leu Asp Ser Glu Pro Glu Thr Ala Arg Asn Leu Phe Ser Val
9805 9810 9815
cct gga gca cca gat aaa cca aca gtt agc agc gtg act cgt aac tcc 29637
Pro Gly Ala Pro Asp Lys Pro Thr Val Ser Ser Val Thr Arg Asn Ser
9820 9825 9830 9835
atg act gtc aac tgg gaa gag cca gaa tat gat gga ggc tct cct gtg 29685
Met Thr Val Asn Trp Glu Glu Pro Glu Tyr Asp Gly Gly Ser Pro Val
9840 9845 9850
aca ggg tac tgg ctg gaa atg aaa gac acc act tca aag aga tgg aag 29733
Thr Gly Tyr Trp Leu Glu Met Lys Asp Thr Thr Ser Lys Arg Trp Lys
9855 9860 9865
aga gtt aac cga gat cct atc aaa gcc atg act ttg ggt gtt tct tat 29781
Arg Val Asn Arg Asp Pro Ile Lys Ala Met Thr Leu Gly Val Ser Tyr
9870 9875 9880
aaa gtg act ggt ctt att gaa ggt tcc gac tat caa ttc cgg gta tat 29829
Lys Val Thr Gly Leu Ile Glu Gly Ser Asp Tyr Gln Phe Arg Val Tyr
9885 9890 9895
gca atc aat gct gct ggc gtg ggt cca gca agt ctg cca tca gac cca 29877
Ala Ile Asn Ala Ala Gly Val Gly Pro Ala Ser Leu Pro Ser Asp Pro
9900 9905 9910 9915
gcg act gct aga gat cca att gcc cct cct ggt cct cca ttt ccc aaa 29925
Ala Thr Ala Arg Asp Pro Ile Ala Pro Pro Gly Pro Pro Phe Pro Lys
9920 9925 9930
gtg aca gat tgg act aaa tca tct gca gat ctg gag tgg tct ccc cca 29973
Val Thr Asp Trp Thr Lys Ser Ser Ala Asp Leu Glu Trp Ser Pro Pro
9935 9940 9945
cta aaa gat ggt gga tcc aaa gta act gga tac atc gtt gaa tat aaa 30021
Leu Lys Asp Gly Gly Ser Lys Val Thr Gly Tyr Ile Val Glu Tyr Lys
9950 9955 9960
gaa gaa gga aaa gaa gaa tgg gaa aag ggt aaa gat aaa gaa gtg aga 30069
Glu Glu Gly Lys Glu Glu Trp Glu Lys Gly Lys Asp Lys Glu Val Arg
9965 9970 9975
gga aca aag ctc gtt gtg aca gga tta aag gaa gga gca ttc tac aaa 30117
Gly Thr Lys Leu Val Val Thr Gly Leu Lys Glu Gly Ala Phe Tyr Lys
9980 9985 9990 9995
ttt aga gtt agt gca gtc aac att gct ggc att gga gaa cct gga gag 30165
Phe Arg Val Ser Ala Val Asn Ile Ala Gly Ile Gly Glu Pro Gly Glu
1000 1000 1001
gtc aca gat gtc att gaa atg aag gac aga ctt gtt tca cct gac ctt 30213
Val Thr Asp Val Ile Glu Met Lys Asp Arg Leu Val Ser Pro Asp Leu
1001 1002 1002
cag cta gat gcc agt gtc aga gat aga att gtt gtc cat gct gga ggg 30261
Gln Leu Asp Ala Ser Val Arg Asp Arg Ile Val Val His Ala Gly Gly
1003 1003 1004
gtg atc cga atc att gcc tat gtg tct gga aag cct cct cca acc gtc 30309
Val Ile Arg Ile Ile Ala Tyr Val Ser Gly Lys Pro Pro Pro Thr Val
1004 1005 1005
acc tgg aac atg aat gaa aga acc tta cct caa gaa gcc acc att gag 30357
Thr Trp Asn Met Asn Glu Arg Thr Leu Pro Gln Glu Ala Thr Ile Glu
1006 1006 1007 1007
acc aca gcc att agc tca tcc atg gtc atc aag aac tgc cag agg agc 30405
Thr Thr Ala Ile Ser Ser Ser Met Val Ile Lys Asn Cys Gln Arg Ser
1008 1008 1009
cat caa ggc gtc tat tct ctt ctt gcc aaa aat gaa gcc gga gaa aga 30453
His Gln Gly Val Tyr Ser Leu Leu Ala Lys Asn Glu Ala Gly Glu Arg
1009 1010 1010
aag aag aca att att gtt gat gta tta gat gtt cca ggt ccc gtt gga 30501
Lys Lys Thr Ile Ile Val Asp Val Leu Asp Val Pro Gly Pro Val Gly
1011 1011 1012
aca cca ttc cta gct cac aac cta acc aat gag tcc tgc aaa ctg aca 30549
Thr Pro Phe Leu Ala His Asn Leu Thr Asn Glu Ser Cys Lys Leu Thr
1012 1013 1013
tgg ttt tct cca gaa gat gat gga ggc tct cca atc acc aat tat gtc 30597
Trp Phe Ser Pro Glu Asp Asp Gly Gly Ser Pro Ile Thr Asn Tyr Val
1014 1014 1015 1015
att gaa aag cgt gaa tct gac cgc aga gca tgg acc cca gtg aca tat 30645
Ile Glu Lys Arg Glu Ser Asp Arg Arg Ala Trp Thr Pro Val Thr Tyr
1016 1016 1017
aca gtt acc cga caa aat gct act gtc cag ggt ctc att caa gga aaa 30693
Thr Val Thr Arg Gln Asn Ala Thr Val Gln Gly Leu Ile Gln Gly Lys
1017 1018 1018
gcc tac ttt ttc cga att gcg gct gaa aat agt att ggc atg ggt cca 30741
Ala Tyr Phe Phe Arg Ile Ala Ala Glu Asn Ser Ile Gly Met Gly Pro
1019 1019 1020
ttt gtt gag aca tca gag gca ctt gtt atc aga gag cca ata act gta 30789
Phe Val Glu Thr Ser Glu Ala Leu Val Ile Arg Glu Pro Ile Thr Val
1020 1021 1021
cca gag cgt cct gaa gac ctg gaa gtc aaa gaa gtt act aaa aat act 30837
Pro Glu Arg Pro Glu Asp Leu Glu Val Lys Glu Val Thr Lys Asn Thr
1022 1022 1023 1023
gta act ttg act tgg aat cct cct aag tat gat ggt ggg tca gaa att 30885
Val Thr Leu Thr Trp Asn Pro Pro Lys Tyr Asp Gly Gly Ser Glu Ile
1024 1024 1025
att aac tat gtc cta gaa agt cgg ctc att ggg act gag aag ttc cac 30933
Ile Asn Tyr Val Leu Glu Ser Arg Leu Ile Gly Thr Glu Lys Phe His
1025 1026 1026
aaa gtt aca aat gac aac ttg ctt agc aga aaa tac act gtt aaa ggc 30981
Lys Val Thr Asn Asp Asn Leu Leu Ser Arg Lys Tyr Thr Val Lys Gly
1027 1027 1028
tta aaa gaa ggt gat acc tat gag tac cgt gtc agt gct gtc aac att 31029
Leu Lys Glu Gly Asp Thr Tyr Glu Tyr Arg Val Ser Ala Val Asn Ile
1028 1029 1029
gtt gga caa ggc aaa cca tca ttt tgc acc aaa cca att act tgc aag 31077
Val Gly Gln Gly Lys Pro Ser Phe Cys Thr Lys Pro Ile Thr Cys Lys
1030 1030 1031 1031
gat gag ctg gca ccc cca acg ctt cac ctc gac ttc aga gat aag ctc 31125
Asp Glu Leu Ala Pro Pro Thr Leu His Leu Asp Phe Arg Asp Lys Leu
1032 1032 1033
acg att cga gtt ggt gaa gct ttt gcc ctc act ggc cgt tac tca ggc 31173
Thr Ile Arg Val Gly Glu Ala Phe Ala Leu Thr Gly Arg Tyr Ser Gly
1033 1034 1034
aaa cca aag cct aag gtt tcc tgg ttc aaa gat gaa gct gat gtg ctg 31221
Lys Pro Lys Pro Lys Val Ser Trp Phe Lys Asp Glu Ala Asp Val Leu
1035 1035 1036
gaa gat gat cgc act cat ata aag act aca cca gca aca ctt gct tta 31269
Glu Asp Asp Arg Thr His Ile Lys Thr Thr Pro Ala Thr Leu Ala Leu
1036 1037 1037
gag aag atc aag gcc aaa cgt tca gat tcc ggc aaa tac tgt gtg gtt 31317
Glu Lys Ile Lys Ala Lys Arg Ser Asp Ser Gly Lys Tyr Cys Val Val
1038 1038 1039 1039
gtg gag aac agt aca ggc tct agg aaa ggt ttc tgt caa gtt aat gtt 31365
Val Glu Asn Ser Thr Gly Ser Arg Lys Gly Phe Cys Gln Val Asn Val
1040 1040 1041
gtt gac cat cct gga cca cca gta gga cca gtt agt ttt gat gag gtg 31413
Val Asp His Pro Gly Pro Pro Val Gly Pro Val Ser Phe Asp Glu Val
1041 1042 1042
acc aaa gat tac atg gtt atc tct tgg aag cct cct tta gat gat gga 31461
Thr Lys Asp Tyr Met Val Ile Ser Trp Lys Pro Pro Leu Asp Asp Gly
1043 1043 1044
ggc agt aaa atc acc aat tat att att gag aag aag gaa gtg ggt aaa 31509
Gly Ser Lys Ile Thr Asn Tyr Ile Ile Glu Lys Lys Glu Val Gly Lys
1044 1045 1045
gac gtc tgg atg cca gtg aca tct gca agt gct aaa aca aca tgc aaa 31557
Asp Val Trp Met Pro Val Thr Ser Ala Ser Ala Lys Thr Thr Cys Lys
1046 1046 1047 1047
gtt tct aaa cta ctt gaa gga aaa gat tat att ttc cgg ata cat gct 31605
Val Ser Lys Leu Leu Glu Gly Lys Asp Tyr Ile Phe Arg Ile His Ala
1048 1048 1049
gaa aat ctg tat gga ata agt gat cct ctg gtg tct gat tca atg aaa 31653
Glu Asn Leu Tyr Gly Ile Ser Asp Pro Leu Val Ser Asp Ser Met Lys
1049 1050 1050
gcc aaa gat cgt ttc agg gtt cct gat gca cct gat cag cca att gtt 31701
Ala Lys Asp Arg Phe Arg Val Pro Asp Ala Pro Asp Gln Pro Ile Val
1051 1051 1052
aca gaa gtt acc aaa gac tct gca tta gta acc tgg aat aag cca cat 31749
Thr Glu Val Thr Lys Asp Ser Ala Leu Val Thr Trp Asn Lys Pro His
1052 1053 1053
gat gga gga aaa ccc atc aca aac tac atc ctg gaa aag aga gaa act 31797
Asp Gly Gly Lys Pro Ile Thr Asn Tyr Ile Leu Glu Lys Arg Glu Thr
1054 1054 1055 1055
atg tct aaa cga tgg gct aga gtt acc aaa gat cct att cat cca tac 31845
Met Ser Lys Arg Trp Ala Arg Val Thr Lys Asp Pro Ile His Pro Tyr
1056 1056 1057
act aaa ttt agg gtt cct gat ctt cta gaa gga tgt cag tat gaa ttc 31893
Thr Lys Phe Arg Val Pro Asp Leu Leu Glu Gly Cys Gln Tyr Glu Phe
1057 1058 1058
cgg gtt tct gca gaa aat gaa att ggt att gga gat cca agc cca cca 31941
Arg Val Ser Ala Glu Asn Glu Ile Gly Ile Gly Asp Pro Ser Pro Pro
1059 1059 1060
tcc aaa cca gtc ttt gct aaa gat cca att gct aaa cca agt cca cct 31989
Ser Lys Pro Val Phe Ala Lys Asp Pro Ile Ala Lys Pro Ser Pro Pro
1060 1061 1061
gtt aat cct gaa gca ata gat aca aca tgc aat tca gtc gat cta act 32037
Val Asn Pro Glu Ala Ile Asp Thr Thr Cys Asn Ser Val Asp Leu Thr
1062 1062 1063 1063
tgg cag cca cca cgt cat gat ggt ggg agc aag att ctg ggt tat att 32085
Trp Gln Pro Pro Arg His Asp Gly Gly Ser Lys Ile Leu Gly Tyr Ile
1064 1064 1065
gtt gag tac cag aaa gtt gga gat gaa gag tgg aga aga gcc aat cac 32133
Val Glu Tyr Gln Lys Val Gly Asp Glu Glu Trp Arg Arg Ala Asn His
1065 1066 1066
acc cct gag tca tgt cct gaa act aaa tat aaa gtc acc ggt ctt cgg 32181
Thr Pro Glu Ser Cys Pro Glu Thr Lys Tyr Lys Val Thr Gly Leu Arg
1067 1067 1068
gac ggt caa acc tat aag ttt aga gtg tta gca gtc aat gca gct ggt 32229
Asp Gly Gln Thr Tyr Lys Phe Arg Val Leu Ala Val Asn Ala Ala Gly
1068 1069 1069
gaa tca gat cca gct cat gtt ccg gag cca gtc cta gta aaa gac agg 32277
Glu Ser Asp Pro Ala His Val Pro Glu Pro Val Leu Val Lys Asp Arg
1070 1070 1071 1071
ctt gaa ccc cct gag ttg att ctt gat gcc aac atg gca aga gaa caa 32325
Leu Glu Pro Pro Glu Leu Ile Leu Asp Ala Asn Met Ala Arg Glu Gln
1072 1072 1073
cac att aaa gtt ggt gat act cta aga ctt agt gcc atc atc aaa gga 32373
His Ile Lys Val Gly Asp Thr Leu Arg Leu Ser Ala Ile Ile Lys Gly
1073 1074 1074
gtg cca ttc cca aaa gta act tgg aaa aaa gaa gac aga gat gct cca 32421
Val Pro Phe Pro Lys Val Thr Trp Lys Lys Glu Asp Arg Asp Ala Pro
1075 1075 1076
act aaa gca aga att gat gtg act cca gtt ggt agc aag ctt gaa att 32469
Thr Lys Ala Arg Ile Asp Val Thr Pro Val Gly Ser Lys Leu Glu Ile
1076 1077 1077
cgt aat gct gcc cat gaa gat ggt gga att tat tct tta aca gtg gag 32517
Arg Asn Ala Ala His Glu Asp Gly Gly Ile Tyr Ser Leu Thr Val Glu
1078 1078 1079 1079
aat cca gct ggt tca aaa act gtc tca gta aaa gta ctt gta tta gat 32565
Asn Pro Ala Gly Ser Lys Thr Val Ser Val Lys Val Leu Val Leu Asp
1080 1080 1081
aaa cct ggg cca cct aga gat ctg gaa gtc agt gaa att agg aaa gat 32613
Lys Pro Gly Pro Pro Arg Asp Leu Glu Val Ser Glu Ile Arg Lys Asp
1081 1082 1082
tca tgt tac ctt act tgg aaa gaa cca cta gat gat ggt ggt tct gtt 32661
Ser Cys Tyr Leu Thr Trp Lys Glu Pro Leu Asp Asp Gly Gly Ser Val
1083 1083 1084
att acc aat tat gtg gtt gag agg aga gat gtt gcc agc gcc cag tgg 32709
Ile Thr Asn Tyr Val Val Glu Arg Arg Asp Val Ala Ser Ala Gln Trp
1084 1085 1085
tca cct ctc tca gct aca tca aag aaa aag agt cac ttc gct aag cat 32757
Ser Pro Leu Ser Ala Thr Ser Lys Lys Lys Ser His Phe Ala Lys His
1086 1086 1087 1087
ctg aat gaa ggc aac cag tac ctc ttc cga gta gct gcg gag aac cag 32805
Leu Asn Glu Gly Asn Gln Tyr Leu Phe Arg Val Ala Ala Glu Asn Gln
1088 1088 1089
tat gga cgt ggt cct ttt gtt gaa aca cca aaa cca atc aag gct ttg 32853
Tyr Gly Arg Gly Pro Phe Val Glu Thr Pro Lys Pro Ile Lys Ala Leu
1089 1090 1090
gat cct ctc cat ccc cca ggg cca ccc aag gac ctg cac cat gta gat 32901
Asp Pro Leu His Pro Pro Gly Pro Pro Lys Asp Leu His His Val Asp
1091 1091 1092
gtt gac aag act gaa gtc tcc cta gtc tgg aat aag ccg gat cgt gat 32949
Val Asp Lys Thr Glu Val Ser Leu Val Trp Asn Lys Pro Asp Arg Asp
1092 1093 1093
ggt ggt tct cca atc act gga tat ttg gta gaa tat caa gaa gaa ggc 32997
Gly Gly Ser Pro Ile Thr Gly Tyr Leu Val Glu Tyr Gln Glu Glu Gly
1094 1094 1095 1095
acc cag gac tgg att aaa ttt aag act gtg aca aac tta gag tgt gtg 33045
Thr Gln Asp Trp Ile Lys Phe Lys Thr Val Thr Asn Leu Glu Cys Val
1096 1096 1097
gtt act gga cta caa caa gga aag acc tat aga ttc cgt gta aaa gct 33093
Val Thr Gly Leu Gln Gln Gly Lys Thr Tyr Arg Phe Arg Val Lys Ala
1097 1098 1098
gaa aac att gtg ggt ctt ggt ctc cct gac aca act atc ccg ata gaa 33141
Glu Asn Ile Val Gly Leu Gly Leu Pro Asp Thr Thr Ile Pro Ile Glu
1099 1099 1100
tgt caa gaa aaa cta gtg cct cca tcc gtg gag cta gat gtg aaa tta 33189
Cys Gln Glu Lys Leu Val Pro Pro Ser Val Glu Leu Asp Val Lys Leu
1100 1101 1101
att gaa ggt ctt gtg gta aag gct gga acc aca gtc aga ttc cct gct 33237
Ile Glu Gly Leu Val Val Lys Ala Gly Thr Thr Val Arg Phe Pro Ala
1102 1102 1103 1103
att ata aga ggt gtg cct gtt cct act gca aag tgg aca acc gat ggg 33285
Ile Ile Arg Gly Val Pro Val Pro Thr Ala Lys Trp Thr Thr Asp Gly
1104 1104 1105
agt gag att aaa acc gat gag cac tac aca gtt gaa aca gac aac ttc 33333
Ser Glu Ile Lys Thr Asp Glu His Tyr Thr Val Glu Thr Asp Asn Phe
1105 1106 1106
tca tca gta ctt acc att aag aac tgc tta agg aga gac act ggg gaa 33381
Ser Ser Val Leu Thr Ile Lys Asn Cys Leu Arg Arg Asp Thr Gly Glu
1107 1107 1108
tat caa atc aca gtt tcc aat gca gcc ggt agc aaa aca gta gcc gta 33429
Tyr Gln Ile Thr Val Ser Asn Ala Ala Gly Ser Lys Thr Val Ala Val
1108 1109 1109
cat ctt act gtt ctt gat gtt cct ggg cca cca aca ggt cct att aat 33477
His Leu Thr Val Leu Asp Val Pro Gly Pro Pro Thr Gly Pro Ile Asn
1110 1110 1111 1111
att ctg gat gtt act cct gaa cac atg act atc tca tgg cag cca cct 33525
Ile Leu Asp Val Thr Pro Glu His Met Thr Ile Ser Trp Gln Pro Pro
1112 1112 1113
aag gat gat gga gga agc cct gtg ata aat tat att gtt gag aaa caa 33573
Lys Asp Asp Gly Gly Ser Pro Val Ile Asn Tyr Ile Val Glu Lys Gln
1113 1114 1114
gat aca agg aaa gac acg tgg ggt gtt gtc tct tcc gga agc agt aag 33621
Asp Thr Arg Lys Asp Thr Trp Gly Val Val Ser Ser Gly Ser Ser Lys
1115 1115 1116
aca aag ctg aaa atc cca cat ctg cag aag ggc tgt gaa tat gtt ttc 33669
Thr Lys Leu Lys Ile Pro His Leu Gln Lys Gly Cys Glu Tyr Val Phe
1116 1117 1117
cga gtt aga gca gag aat aag ata ggt gtt ggt cct ccc ctt gac tcc 33717
Arg Val Arg Ala Glu Asn Lys Ile Gly Val Gly Pro Pro Leu Asp Ser
1118 1118 1119 1119
aca cct act gtt gct aag cat aaa ttt agt cct ccg tct cct cct ggt 33765
Thr Pro Thr Val Ala Lys His Lys Phe Ser Pro Pro Ser Pro Pro Gly
1120 1120 1121
aaa cca gtg gtt act gac att act gaa aat gca gca aca gtg tct tgg 33813
Lys Pro Val Val Thr Asp Ile Thr Glu Asn Ala Ala Thr Val Ser Trp
1121 1122 1122
acc ctg cca aaa tct gat ggt ggc agt cca ata act ggc tac tat atg 33861
Thr Leu Pro Lys Ser Asp Gly Gly Ser Pro Ile Thr Gly Tyr Tyr Met
1123 1123 1124
gaa cgt cga gaa gta act ggc aaa tgg gtg agg gtc aac aaa aca cct 33909
Glu Arg Arg Glu Val Thr Gly Lys Trp Val Arg Val Asn Lys Thr Pro
1124 1125 1125
atc gct gac ctg aag ttc aga gtg act gga ctc tat gaa gga aat aca 33957
Ile Ala Asp Leu Lys Phe Arg Val Thr Gly Leu Tyr Glu Gly Asn Thr
1126 1126 1127 1127
tat gag ttt aga gtt ttt gct gaa aat ctt gca gga cta agc aaa cca 34005
Tyr Glu Phe Arg Val Phe Ala Glu Asn Leu Ala Gly Leu Ser Lys Pro
1128 1128 1129
tcc cca agt tct gat cca ata aaa gct tgc cgg ccc atc aaa cca cct 34053
Ser Pro Ser Ser Asp Pro Ile Lys Ala Cys Arg Pro Ile Lys Pro Pro
1129 1130 1130
gga cca cct att aat cct aaa ctg aaa gac aag agc aga gaa aca gct 34101
Gly Pro Pro Ile Asn Pro Lys Leu Lys Asp Lys Ser Arg Glu Thr Ala
1131 1131 1132
gat ttg gtg tgg aca aag cct ctc agt gat ggt ggt agc ccc att cta 34149
Asp Leu Val Trp Thr Lys Pro Leu Ser Asp Gly Gly Ser Pro Ile Leu
1132 1133 1133
gga tat gta gtg gaa tgt cag aaa cct ggc acg gca caa tgg aac agg 34197
Gly Tyr Val Val Glu Cys Gln Lys Pro Gly Thr Ala Gln Trp Asn Arg
1134 1134 1135 1135
att aat aaa gat gaa ctc att agg caa tgt gcc ttt agg gta cct gga 34245
Ile Asn Lys Asp Glu Leu Ile Arg Gln Cys Ala Phe Arg Val Pro Gly
1136 1136 1137
cta att gaa gga aat gag tac aga ttc cgt ata aag gca gct aat att 34293
Leu Ile Glu Gly Asn Glu Tyr Arg Phe Arg Ile Lys Ala Ala Asn Ile
1137 1138 1138
gta gga gag ggt gag cca aga gaa cta gca gaa tct gtg att gca aaa 34341
Val Gly Glu Gly Glu Pro Arg Glu Leu Ala Glu Ser Val Ile Ala Lys
1139 1139 1140
gat atc ctt cat cct cca gaa gta gaa ctt gat gtt act tgt cgt gat 34389
Asp Ile Leu His Pro Pro Glu Val Glu Leu Asp Val Thr Cys Arg Asp
1140 1141 1141
gtt att acc gtg aga gta ggc caa act atc cgc att cta gct cga gtc 34437
Val Ile Thr Val Arg Val Gly Gln Thr Ile Arg Ile Leu Ala Arg Val
1142 1142 1143 1143
aaa ggc aga cct gaa cca gac ata act tgg act aag gaa ggc aaa gta 34485
Lys Gly Arg Pro Glu Pro Asp Ile Thr Trp Thr Lys Glu Gly Lys Val
1144 1144 1145
ttg gtc cga gaa aag agg gtg gac ctt att cag gat cta cct cgt gtt 34533
Leu Val Arg Glu Lys Arg Val Asp Leu Ile Gln Asp Leu Pro Arg Val
1145 1146 1146
gag tta caa att aaa gaa gct gtt aga gct gat cat ggc aag tat atc 34581
Glu Leu Gln Ile Lys Glu Ala Val Arg Ala Asp His Gly Lys Tyr Ile
1147 1147 1148
atc tca gct aag aac agc agt gga cat gcc caa ggt tca gcc atc gtt 34629
Ile Ser Ala Lys Asn Ser Ser Gly His Ala Gln Gly Ser Ala Ile Val
1148 1149 1149
aac gtc ctt gac aga cct ggg cct tgc cag aat ttg aag gtt acc aat 34677
Asn Val Leu Asp Arg Pro Gly Pro Cys Gln Asn Leu Lys Val Thr Asn
1150 1150 1151 1151
gta acc aaa gag aac tgt aca att tct tgg gaa aac cca cta gat aat 34725
Val Thr Lys Glu Asn Cys Thr Ile Ser Trp Glu Asn Pro Leu Asp Asn
1152 1152 1153
ggt ggc tca gaa ata aca aac ttc ata gta gaa tat cgc aaa cca aac 34773
Gly Gly Ser Glu Ile Thr Asn Phe Ile Val Glu Tyr Arg Lys Pro Asn
1153 1154 1154
cag aaa ggc tgg tca att gtt gca tca gat gtc act aaa cga tta atc 34821
Gln Lys Gly Trp Ser Ile Val Ala Ser Asp Val Thr Lys Arg Leu Ile
1155 1155 1156
aag gcc aac ctt tta gcc aac aat gaa tac tat ttc cga gtt tgt gca 34869
Lys Ala Asn Leu Leu Ala Asn Asn Glu Tyr Tyr Phe Arg Val Cys Ala
1156 1157 1157
gag aat aaa gta ggt gtt ggg cca acc atc gaa aca aaa act ccc att 34917
Glu Asn Lys Val Gly Val Gly Pro Thr Ile Glu Thr Lys Thr Pro Ile
1158 1158 1159 1159
ctg gct att aac cct att gac aga cca ggt gag cct gaa aac ctt cac 34965
Leu Ala Ile Asn Pro Ile Asp Arg Pro Gly Glu Pro Glu Asn Leu His
1160 1160 1161
att gca gat aaa gga aag aca ttt gtc tac cta aag tgg cgg agg cct 35013
Ile Ala Asp Lys Gly Lys Thr Phe Val Tyr Leu Lys Trp Arg Arg Pro
1161 1162 1162
gac tat gat ggt ggc agt cca aat ctg tca tat cat gtt gag aga agg 35061
Asp Tyr Asp Gly Gly Ser Pro Asn Leu Ser Tyr His Val Glu Arg Arg
1163 1163 1164
ctt aag ggc tcc gat gac tgg gaa aga gtg cat aaa gga agc att aaa 35109
Leu Lys Gly Ser Asp Asp Trp Glu Arg Val His Lys Gly Ser Ile Lys
1164 1165 1165
gaa act cac tac atg gtt gac aga tgt gtt gaa aac cag att tat gag 35157
Glu Thr His Tyr Met Val Asp Arg Cys Val Glu Asn Gln Ile Tyr Glu
1166 1166 1167 1167
ttc aga gtg caa aca aag aat gaa ggt ggg gaa agt gac tgg gtg aag 35205
Phe Arg Val Gln Thr Lys Asn Glu Gly Gly Glu Ser Asp Trp Val Lys
1168 1168 1169
aca gag gaa gtt gtt gtg aaa gaa gac tta caa aaa cca gta ctt gat 35253
Thr Glu Glu Val Val Val Lys Glu Asp Leu Gln Lys Pro Val Leu Asp
1169 1170 1170
ctg aaa tta agt ggg gtc cta act gtc aaa gca ggg gac acc att agg 35301
Leu Lys Leu Ser Gly Val Leu Thr Val Lys Ala Gly Asp Thr Ile Arg
1171 1171 1172
ctt gag gca ggg gtt aga ggc aaa cca ttc cca gaa gtt gca tgg acc 35349
Leu Glu Ala Gly Val Arg Gly Lys Pro Phe Pro Glu Val Ala Trp Thr
1172 1173 1173
aag gac aaa gac gct aca gac tta aca aga tca cca agg gtc aag att 35397
Lys Asp Lys Asp Ala Thr Asp Leu Thr Arg Ser Pro Arg Val Lys Ile
1174 1174 1175 1175
gat acc cgt gct gat tca tct aaa ttt tct ctt act aaa gca aag cga 35445
Asp Thr Arg Ala Asp Ser Ser Lys Phe Ser Leu Thr Lys Ala Lys Arg
1176 1176 1177
agt gat ggg ggt aaa tat gta gtt acg gca act aac acg gct ggc agt 35493
Ser Asp Gly Gly Lys Tyr Val Val Thr Ala Thr Asn Thr Ala Gly Ser
1177 1178 1178
ttt gtg gcc tat gcc act gtc aat gtt tta gat aag cct ggt cct gtg 35541
Phe Val Ala Tyr Ala Thr Val Asn Val Leu Asp Lys Pro Gly Pro Val
1179 1179 1180
aga aat ctg aaa att gtt gat gtg tcc agt gat agg tgt act gtt tgc 35589
Arg Asn Leu Lys Ile Val Asp Val Ser Ser Asp Arg Cys Thr Val Cys
1180 1181 1181
tgg gat cca cca gaa gat gat ggt ggc tgt gaa atc caa aat tat att 35637
Trp Asp Pro Pro Glu Asp Asp Gly Gly Cys Glu Ile Gln Asn Tyr Ile
1182 1182 1183 1183
cta gaa aaa tgt gag aca aag cga atg gtt tgg tct acc tat tct gct 35685
Leu Glu Lys Cys Glu Thr Lys Arg Met Val Trp Ser Thr Tyr Ser Ala
1184 1184 1185
act gtc ttg aca cct ggt act aca gta aca cgt ctc ata gaa gga aat 35733
Thr Val Leu Thr Pro Gly Thr Thr Val Thr Arg Leu Ile Glu Gly Asn
1185 1186 1186
gaa tat att ttc aga gtc cgt gca gaa aat aaa ata ggc aca ggg cct 35781
Glu Tyr Ile Phe Arg Val Arg Ala Glu Asn Lys Ile Gly Thr Gly Pro
1187 1187 1188
cca aca gaa agt aaa cca gtc ata gcc aaa acc aag tat gat aaa cct 35829
Pro Thr Glu Ser Lys Pro Val Ile Ala Lys Thr Lys Tyr Asp Lys Pro
1188 1189 1189
ggt cgc cct gat ccc cca gaa gtc act aaa gta agc aaa gaa gag atg 35877
Gly Arg Pro Asp Pro Pro Glu Val Thr Lys Val Ser Lys Glu Glu Met
1190 1190 1191 1191
act gtg gtt tgg aat cca cct gaa tat gat ggt gga aag tct ata act 35925
Thr Val Val Trp Asn Pro Pro Glu Tyr Asp Gly Gly Lys Ser Ile Thr
1192 1192 1193
gga tac ttt ttg gag aaa aag gaa aag cat tca aca cga tgg gtc cct 35973
Gly Tyr Phe Leu Glu Lys Lys Glu Lys His Ser Thr Arg Trp Val Pro
1193 1194 1194
gtc aac aag agt gca atc cct gag aga cgt atg aaa gta cag aat ctc 36021
Val Asn Lys Ser Ala Ile Pro Glu Arg Arg Met Lys Val Gln Asn Leu
1195 1195 1196
ctc cca gac cat gaa tat cag ttc cgt gtc aag gca gaa aat gaa att 36069
Leu Pro Asp His Glu Tyr Gln Phe Arg Val Lys Ala Glu Asn Glu Ile
1196 1197 1197
gga att gga gaa cca agc ttg cct tca aga ccg gtg gtg gca aaa gac 36117
Gly Ile Gly Glu Pro Ser Leu Pro Ser Arg Pro Val Val Ala Lys Asp
1198 1198 1199 1199
ccc ata gag cca cct ggt cca cca acc aat ttc aga gtg gtt gat aca 36165
Pro Ile Glu Pro Pro Gly Pro Pro Thr Asn Phe Arg Val Val Asp Thr
1200 1200 1201
acc aaa cat tcc ata act ctt ggg tgg gga aaa cca gtc tat gat ggt 36213
Thr Lys His Ser Ile Thr Leu Gly Trp Gly Lys Pro Val Tyr Asp Gly
1201 1202 1202
ggt gca ccg atc att gga tat gtt gtg gaa atg aga cca aaa ata gca 36261
Gly Ala Pro Ile Ile Gly Tyr Val Val Glu Met Arg Pro Lys Ile Ala
1203 1203 1204
gat gcg tct cct gat gaa ggc tgg aaa cgg tgt aat gct gca gca cag 36309
Asp Ala Ser Pro Asp Glu Gly Trp Lys Arg Cys Asn Ala Ala Ala Gln
1204 1205 1205
ctt gta cgc aag gaa ttc act gtt acc agc ttg gat gaa aac cag gaa 36357
Leu Val Arg Lys Glu Phe Thr Val Thr Ser Leu Asp Glu Asn Gln Glu
1206 1206 1207 1207
tat gag ttc agg gtg tgt gcc caa aac caa gtt ggt att ggg cgc cct 36405
Tyr Glu Phe Arg Val Cys Ala Gln Asn Gln Val Gly Ile Gly Arg Pro
1208 1208 1209
gca gag cta aag gaa gct atc aaa cct aaa gaa ata cta gaa cct ccg 36453
Ala Glu Leu Lys Glu Ala Ile Lys Pro Lys Glu Ile Leu Glu Pro Pro
1209 1210 1210
gag att gat ttg gat gcc agc atg agg aaa ctg gtc ata gtg aga gca 36501
Glu Ile Asp Leu Asp Ala Ser Met Arg Lys Leu Val Ile Val Arg Ala
1211 1211 1212
gga tgc cct att cgt ctc ttt gct ata gtg aga gga cga cca gcc cct 36549
Gly Cys Pro Ile Arg Leu Phe Ala Ile Val Arg Gly Arg Pro Ala Pro
1212 1213 1213
aaa gtc act tgg cga aaa gtt ggc att gat aat gtg gtc aga aaa gga 36597
Lys Val Thr Trp Arg Lys Val Gly Ile Asp Asn Val Val Arg Lys Gly
1214 1214 1215 1215
caa gtt gat ctg gtt gac act atg gcc ttc ctt gtc atc ccc aat tct 36645
Gln Val Asp Leu Val Asp Thr Met Ala Phe Leu Val Ile Pro Asn Ser
1216 1216 1217
acc cgt gat gac tca gga aaa tat tcc tta aca ctt gtg aac cca gca 36693
Thr Arg Asp Asp Ser Gly Lys Tyr Ser Leu Thr Leu Val Asn Pro Ala
1217 1218 1218
gga gaa aag gct gta ttc gta aat gtc aga gta tta gac act cct ggg 36741
Gly Glu Lys Ala Val Phe Val Asn Val Arg Val Leu Asp Thr Pro Gly
1219 1219 1220
cct gtg tct gat tta aaa gtt tca gat gtc act aaa aca tca tgc cat 36789
Pro Val Ser Asp Leu Lys Val Ser Asp Val Thr Lys Thr Ser Cys His
1220 1221 1221
gtg tcc tgg gcc cct cct gaa aac gac ggt ggg agc caa gtg aca cat 36837
Val Ser Trp Ala Pro Pro Glu Asn Asp Gly Gly Ser Gln Val Thr His
1222 1222 1223 1223
tat atc gtg gag aaa cgt gag gca gac aga aag aca tgg tcg acc gtt 36885
Tyr Ile Val Glu Lys Arg Glu Ala Asp Arg Lys Thr Trp Ser Thr Val
1224 1224 1225
acc cca gaa gtt aag aaa aca agc ttc cat gta acc aat ctt gtc cct 36933
Thr Pro Glu Val Lys Lys Thr Ser Phe His Val Thr Asn Leu Val Pro
1225 1226 1226
ggg aat gag tat tac ttc aga gta act gct gtc aac gaa tat ggc cct 36981
Gly Asn Glu Tyr Tyr Phe Arg Val Thr Ala Val Asn Glu Tyr Gly Pro
1227 1227 1228
ggc gtc cca aca gat gtc cca aaa cca gtg ctt gca tca gat cct cta 37029
Gly Val Pro Thr Asp Val Pro Lys Pro Val Leu Ala Ser Asp Pro Leu
1228 1229 1229
agt gag ccg gat ccc cca agg aaa tta gaa gcg act gaa atg acc aag 37077
Ser Glu Pro Asp Pro Pro Arg Lys Leu Glu Ala Thr Glu Met Thr Lys
1230 1230 1231 1231
aac agt gcc acc tta gcc tgg tta cct ccc cta cgt gat gga ggt gct 37125
Asn Ser Ala Thr Leu Ala Trp Leu Pro Pro Leu Arg Asp Gly Gly Ala
1232 1232 1233
aaa atc gat ggc tac atc att agt tac aga gaa gaa gag cag cct gca 37173
Lys Ile Asp Gly Tyr Ile Ile Ser Tyr Arg Glu Glu Glu Gln Pro Ala
1233 1234 1234
gat cgc tgg aca gag tac tca gtg gta aaa gat ctg agc ctt gtt gtc 37221
Asp Arg Trp Thr Glu Tyr Ser Val Val Lys Asp Leu Ser Leu Val Val
1235 1235 1236
act ggc cta aag gaa gga aag aaa tac aaa ttt aga gta gcg gcc aga 37269
Thr Gly Leu Lys Glu Gly Lys Lys Tyr Lys Phe Arg Val Ala Ala Arg
1236 1237 1237
aat gct gtt gga gtc agt ttg cca aga gaa gct gaa gga gtg tat gaa 37317
Asn Ala Val Gly Val Ser Leu Pro Arg Glu Ala Glu Gly Val Tyr Glu
1238 1238 1239 1239
gcc aaa gag caa ctg ttg cca cca aag atc ctt atg cca gag caa ata 37365
Ala Lys Glu Gln Leu Leu Pro Pro Lys Ile Leu Met Pro Glu Gln Ile
1240 1240 1241
act atc aaa gct ggg aaa aaa ctc cga att gaa gcc cat gtg tat gga 37413
Thr Ile Lys Ala Gly Lys Lys Leu Arg Ile Glu Ala His Val Tyr Gly
1241 1242 1242
aag cct cat ccc acc tgt aaa tgg aaa aaa gga gaa gat gaa gtt gtc 37461
Lys Pro His Pro Thr Cys Lys Trp Lys Lys Gly Glu Asp Glu Val Val
1243 1243 1244
aca tcc agc cac ctg gca gtg cat aaa gca gac agc tct tca att ctg 37509
Thr Ser Ser His Leu Ala Val His Lys Ala Asp Ser Ser Ser Ile Leu
1244 1245 1245
atc ata aaa gat gtg act agg aaa gac agt ggt tac tac agc ctc aca 37557
Ile Ile Lys Asp Val Thr Arg Lys Asp Ser Gly Tyr Tyr Ser Leu Thr
1246 1246 1247 1247
gca gag aac agt tct ggg aca gac act cag aaa atc aaa gtt gta gtc 37605
Ala Glu Asn Ser Ser Gly Thr Asp Thr Gln Lys Ile Lys Val Val Val
1248 1248 1249
atg gat gcc ccc ggc ccc cct cag cct cca ttt gac att tct gat ata 37653
Met Asp Ala Pro Gly Pro Pro Gln Pro Pro Phe Asp Ile Ser Asp Ile
1249 1250 1250
gac gct gat gct tgc tcc ctg tca tgg cac atc cct ctg gag gac gga 37701
Asp Ala Asp Ala Cys Ser Leu Ser Trp His Ile Pro Leu Glu Asp Gly
1251 1251 1252
ggc agt aac atc acc aat tat ata gtg gag aag tgt gat gta agc cga 37749
Gly Ser Asn Ile Thr Asn Tyr Ile Val Glu Lys Cys Asp Val Ser Arg
1252 1253 1253
ggt gac tgg gtc acg gct cta gct tca gtc aca aaa act tcc tgc agg 37797
Gly Asp Trp Val Thr Ala Leu Ala Ser Val Thr Lys Thr Ser Cys Arg
1254 1254 1255 1255
gtt gga aag ctg atc cca ggc caa gag tac atc ttc cgg gtc cgt gct 37845
Val Gly Lys Leu Ile Pro Gly Gln Glu Tyr Ile Phe Arg Val Arg Ala
1256 1256 1257
gaa aac cga ttt ggc att tca gag cct ctc aca tct cca aag atg gtt 37893
Glu Asn Arg Phe Gly Ile Ser Glu Pro Leu Thr Ser Pro Lys Met Val
1257 1258 1258
gcg cag ttc cca ttt ggt gtt cct agt gaa cca aag aat gca cga gtc 37941
Ala Gln Phe Pro Phe Gly Val Pro Ser Glu Pro Lys Asn Ala Arg Val
1259 1259 1260
acc aaa gtc aac aag gac tgt att ttt gtt gct tgg gac aga cca gat 37989
Thr Lys Val Asn Lys Asp Cys Ile Phe Val Ala Trp Asp Arg Pro Asp
1260 1261 1261
agt gat gga ggg agc ccc att att ggt tat ctg att gaa cgc aag gaa 38037
Ser Asp Gly Gly Ser Pro Ile Ile Gly Tyr Leu Ile Glu Arg Lys Glu
1262 1262 1263 1263
aga aac agt ttg ctg tgg gtg aaa gcc aat gat act ctt gtc cgg tca 38085
Arg Asn Ser Leu Leu Trp Val Lys Ala Asn Asp Thr Leu Val Arg Ser
1264 1264 1265
act gaa tat cct tgt gct ggc ctt gta gaa ggt ctt gag tat tca ttc 38133
Thr Glu Tyr Pro Cys Ala Gly Leu Val Glu Gly Leu Glu Tyr Ser Phe
1265 1266 1266
aga atc tat gcc cta aac aaa gct gga tcc agc cca ccc agc aaa ccc 38181
Arg Ile Tyr Ala Leu Asn Lys Ala Gly Ser Ser Pro Pro Ser Lys Pro
1267 1267 1268
aca gaa tat gta act gca aga atg cca gtt gat cct cct ggg aaa cct 38229
Thr Glu Tyr Val Thr Ala Arg Met Pro Val Asp Pro Pro Gly Lys Pro
1268 1269 1269
gag gtt att gat gtc acc aag agt act gta tct ctg atc tgg gct cgt 38277
Glu Val Ile Asp Val Thr Lys Ser Thr Val Ser Leu Ile Trp Ala Arg
1270 1270 1271 1271
cca aag cat gat gga ggc agt aaa att att ggc tat ttc gta gaa gct 38325
Pro Lys His Asp Gly Gly Ser Lys Ile Ile Gly Tyr Phe Val Glu Ala
1272 1272 1273
tgc aaa ctt cct ggt gat aaa tgg gta cgg tgc aat act gca cct cac 38373
Cys Lys Leu Pro Gly Asp Lys Trp Val Arg Cys Asn Thr Ala Pro His
1273 1274 1274
cag att ccc cag gaa gag tac aca gct act ggc cta gaa gag aaa gct 38421
Gln Ile Pro Gln Glu Glu Tyr Thr Ala Thr Gly Leu Glu Glu Lys Ala
1275 1275 1276
cag tat caa ttt aga gct att gcc agg acc gcg gta aac att agc cca 38469
Gln Tyr Gln Phe Arg Ala Ile Ala Arg Thr Ala Val Asn Ile Ser Pro
1276 1277 1277
cct tct gaa cct tct gat cca gtg act atc ctc gca gaa aat gtc cct 38517
Pro Ser Glu Pro Ser Asp Pro Val Thr Ile Leu Ala Glu Asn Val Pro
1278 1278 1279 1279
ccc agg ata gac ctg agt gtg gct atg aaa tct ttg ctt act gtg aaa 38565
Pro Arg Ile Asp Leu Ser Val Ala Met Lys Ser Leu Leu Thr Val Lys
1280 1280 1281
gct gga act aat gtc tgc ttg gat gct act gtt ttt ggt aaa ccg atg 38613
Ala Gly Thr Asn Val Cys Leu Asp Ala Thr Val Phe Gly Lys Pro Met
1281 1282 1282
cca aca gtt tct tgg aaa aaa gat ggc aca ctg cta aaa cca gca gaa 38661
Pro Thr Val Ser Trp Lys Lys Asp Gly Thr Leu Leu Lys Pro Ala Glu
1283 1283 1284
ggc ata aag atg gcc atg cag cgg aat ctg tgc acc ttg gag cta ttc 38709
Gly Ile Lys Met Ala Met Gln Arg Asn Leu Cys Thr Leu Glu Leu Phe
1284 1285 1285
agc gtg aac cgg aag gac tca gga gac tat acc att act gct gaa aat 38757
Ser Val Asn Arg Lys Asp Ser Gly Asp Tyr Thr Ile Thr Ala Glu Asn
1286 1286 1287 1287
tca agt ggt tct aaa tca gcc acc att aag ctt aaa gtg tta gat aaa 38805
Ser Ser Gly Ser Lys Ser Ala Thr Ile Lys Leu Lys Val Leu Asp Lys
1288 1288 1289
ccg ggt cct cca gca tct gtt aaa atc aac aaa atg tat tca gat cgt 38853
Pro Gly Pro Pro Ala Ser Val Lys Ile Asn Lys Met Tyr Ser Asp Arg
1289 1290 1290
gct atg ctt tct tgg gaa ccg cct ctt gaa gat gga ggc tca gaa atc 38901
Ala Met Leu Ser Trp Glu Pro Pro Leu Glu Asp Gly Gly Ser Glu Ile
1291 1291 1292
acc aac tat att gtt gac aaa cgt gaa aca agc agg ccc aac tgg gct 38949
Thr Asn Tyr Ile Val Asp Lys Arg Glu Thr Ser Arg Pro Asn Trp Ala
1292 1293 1293
caa gtc tct gca act gtg cct atc acc agc tgc agc gtg gag aaa ctt 38997
Gln Val Ser Ala Thr Val Pro Ile Thr Ser Cys Ser Val Glu Lys Leu
1294 1294 1295 1295
ata gag ggc cat gag tat cag ttc cgt att tgt gct gaa aat aaa tat 39045
Ile Glu Gly His Glu Tyr Gln Phe Arg Ile Cys Ala Glu Asn Lys Tyr
1296 1296 1297
gga gta ggc gat cca gtc ttc act gaa cca gca att gcc aaa aac cca 39093
Gly Val Gly Asp Pro Val Phe Thr Glu Pro Ala Ile Ala Lys Asn Pro
1297 1298 1298
tat gac cca cca gga cgc tgt gat cct cct gtt att agc aac ata acc 39141
Tyr Asp Pro Pro Gly Arg Cys Asp Pro Pro Val Ile Ser Asn Ile Thr
1299 1299 1300
aaa gat cac atg aca gtc agc tgg aag cca cca gca gat gat ggg ggc 39189
Lys Asp His Met Thr Val Ser Trp Lys Pro Pro Ala Asp Asp Gly Gly
1300 1301 1301
tca ccc atc act ggc tat ttg ctt gaa aag cgg gaa acc cag gct gtt 39237
Ser Pro Ile Thr Gly Tyr Leu Leu Glu Lys Arg Glu Thr Gln Ala Val
1302 1302 1303 1303
aac tgg act aag gtc aac aga aaa cct att ata gaa aga aca tta aaa 39285
Asn Trp Thr Lys Val Asn Arg Lys Pro Ile Ile Glu Arg Thr Leu Lys
1304 1304 1305
gca aca ggt ctt caa gaa ggt acc gaa tat gag ttc cgt gtt aca gct 39333
Ala Thr Gly Leu Gln Glu Gly Thr Glu Tyr Glu Phe Arg Val Thr Ala
1305 1306 1306
ata aat aaa gct gga cca ggc aaa ccc agt gac gca tcc aag gcc gct 39381
Ile Asn Lys Ala Gly Pro Gly Lys Pro Ser Asp Ala Ser Lys Ala Ala
1307 1307 1308
tat gct cgg gac cct cag tat cct cct gcg cca ccg gct ttc cct aaa 39429
Tyr Ala Arg Asp Pro Gln Tyr Pro Pro Ala Pro Pro Ala Phe Pro Lys
1308 1309 1309
gta tat gat aca act cgc agc tct gtg agt cta tct tgg ggc aag cca 39477
Val Tyr Asp Thr Thr Arg Ser Ser Val Ser Leu Ser Trp Gly Lys Pro
1310 1310 1311 1311
gcc tat gac ggc ggc agc cct atc att ggt tat ctc gtt gaa gta aaa 39525
Ala Tyr Asp Gly Gly Ser Pro Ile Ile Gly Tyr Leu Val Glu Val Lys
1312 1312 1313
cgg gct gac tcc gat aac tgg gtg agg tgc aac tta cca cag aat cta 39573
Arg Ala Asp Ser Asp Asn Trp Val Arg Cys Asn Leu Pro Gln Asn Leu
1313 1314 1314
cag aaa acc cgc ttt gag gtt act ggc ctg atg gaa gac aca caa tat 39621
Gln Lys Thr Arg Phe Glu Val Thr Gly Leu Met Glu Asp Thr Gln Tyr
1315 1315 1316
caa ttc cgt gtg tat gcc gtt aat aag att gga tac agt gac ccc agt 39669
Gln Phe Arg Val Tyr Ala Val Asn Lys Ile Gly Tyr Ser Asp Pro Ser
1316 1317 1317
gat gtg cca gat aaa cac tat ccc aag gac atc tta att cca cct gag 39717
Asp Val Pro Asp Lys His Tyr Pro Lys Asp Ile Leu Ile Pro Pro Glu
1318 1318 1319 1319
gga gaa cat gat gcg gac tta agg aag aca ctc ata tta cgt gct gga 39765
Gly Glu His Asp Ala Asp Leu Arg Lys Thr Leu Ile Leu Arg Ala Gly
1320 1320 1321
gtt act atg aga cta tat gta cca gta aaa gga cgc cca cct cca aag 39813
Val Thr Met Arg Leu Tyr Val Pro Val Lys Gly Arg Pro Pro Pro Lys
1321 1322 1322
att act tgg tct aaa cca aat gtc aat cta aga gac agg att gga ctg 39861
Ile Thr Trp Ser Lys Pro Asn Val Asn Leu Arg Asp Arg Ile Gly Leu
1323 1323 1324
gac ata aag tca act gac ttt gac act ttc ttg cgc tgt gaa aat gtg 39909
Asp Ile Lys Ser Thr Asp Phe Asp Thr Phe Leu Arg Cys Glu Asn Val
1324 1325 1325
aac aaa tat gat gca gga aaa tat atc tta acc ctg gag aac agc tgt 39957
Asn Lys Tyr Asp Ala Gly Lys Tyr Ile Leu Thr Leu Glu Asn Ser Cys
1326 1326 1327 1327
ggt aaa aag gaa tat acc att gtt gtg aaa gtg ctt gat act cct ggg 40005
Gly Lys Lys Glu Tyr Thr Ile Val Val Lys Val Leu Asp Thr Pro Gly
1328 1328 1329
cca cct atc aat gtg act gtt aag gaa ata tcc aaa gac tct gct tat 40053
Pro Pro Ile Asn Val Thr Val Lys Glu Ile Ser Lys Asp Ser Ala Tyr
1329 1330 1330
gtt acc tgg gag cct ccc att att gat ggc gga agc ccc atc ata aac 40101
Val Thr Trp Glu Pro Pro Ile Ile Asp Gly Gly Ser Pro Ile Ile Asn
1331 1331 1332
tat gtg gta caa aaa cgt gat gca gag agg aaa tcc tgg tct aca gtg 40149
Tyr Val Val Gln Lys Arg Asp Ala Glu Arg Lys Ser Trp Ser Thr Val
1332 1333 1333
aca act gag tgc tcc aaa aca agc ttc aga gta cct aat ttg gag gag 40197
Thr Thr Glu Cys Ser Lys Thr Ser Phe Arg Val Pro Asn Leu Glu Glu
1334 1334 1335 1335
gga aaa tcc tac ttc ttc cga gtg ttt gct gaa aat gag tat ggc att 40245
Gly Lys Ser Tyr Phe Phe Arg Val Phe Ala Glu Asn Glu Tyr Gly Ile
1336 1336 1337
ggt gat ccc ggt gaa act cgt gat gct gtc aaa gct tcc caa act cct 40293
Gly Asp Pro Gly Glu Thr Arg Asp Ala Val Lys Ala Ser Gln Thr Pro
1337 1338 1338
gga cca gtt gtg gac ctg aaa gtg agg tct gta tct aag tca tcc tgt 40341
Gly Pro Val Val Asp Leu Lys Val Arg Ser Val Ser Lys Ser Ser Cys
1339 1339 1340
agc att ggc tgg aaa aag cct cac agt gat ggt gga agt cgg att att 40389
Ser Ile Gly Trp Lys Lys Pro His Ser Asp Gly Gly Ser Arg Ile Ile
1340 1341 1341
gga tat gta gtt gat ttc ctg act gaa gaa aat aag tgg caa cga gtt 40437
Gly Tyr Val Val Asp Phe Leu Thr Glu Glu Asn Lys Trp Gln Arg Val
1342 1342 1343 1343
atg aaa tcc tta agc cta cag tac tct gca aaa gat ttg act gaa ggg 40485
Met Lys Ser Leu Ser Leu Gln Tyr Ser Ala Lys Asp Leu Thr Glu Gly
1344 1344 1345
aag gaa tat acc ttc aga gtg agt gct gag aat gaa aat gga gaa gga 40533
Lys Glu Tyr Thr Phe Arg Val Ser Ala Glu Asn Glu Asn Gly Glu Gly
1345 1346 1346
acc cca agc gaa atc act gtt gtg gca agg gat gat gtt gtg gct cct 40581
Thr Pro Ser Glu Ile Thr Val Val Ala Arg Asp Asp Val Val Ala Pro
1347 1347 1348
gat ctt gac tta aag ggt cta cct gat ttg tgc tac ttg gct aaa gaa 40629
Asp Leu Asp Leu Lys Gly Leu Pro Asp Leu Cys Tyr Leu Ala Lys Glu
1348 1349 1349
aac agc aac ttc cgg ctt aag atc ccc ata aaa ggc aag cca gct cca 40677
Asn Ser Asn Phe Arg Leu Lys Ile Pro Ile Lys Gly Lys Pro Ala Pro
1350 1350 1351 1351
tca gtc tcc tgg aag aaa ggg gaa gat cct cta gca act gac act aga 40725
Ser Val Ser Trp Lys Lys Gly Glu Asp Pro Leu Ala Thr Asp Thr Arg
1352 1352 1353
gtc agt gtt gag tca tct gcg gtt aac aca act ctt ata gtg tac gat 40773
Val Ser Val Glu Ser Ser Ala Val Asn Thr Thr Leu Ile Val Tyr Asp
1353 1354 1354
tgc caa aaa tct gat gct gga aaa tac aca atc aca ctt aag aat gtt 40821
Cys Gln Lys Ser Asp Ala Gly Lys Tyr Thr Ile Thr Leu Lys Asn Val
1355 1355 1356
gct ggc acc aag gaa gga act atc tcc ata aag gtt gtt ggc aag cct 40869
Ala Gly Thr Lys Glu Gly Thr Ile Ser Ile Lys Val Val Gly Lys Pro
1356 1357 1357
ggc atc ccc act gga cca atc aaa ttt gat gaa gtc aca gca gaa gcc 40917
Gly Ile Pro Thr Gly Pro Ile Lys Phe Asp Glu Val Thr Ala Glu Ala
1358 1358 1359 1359
atg acc tta aag tgg gct cct cca aag gat gat gga ggt tct gaa atc 40965
Met Thr Leu Lys Trp Ala Pro Pro Lys Asp Asp Gly Gly Ser Glu Ile
1360 1360 1361
acc aac tat atc cta gag aag agg gat tct gtg aac aac aag tgg gtg 41013
Thr Asn Tyr Ile Leu Glu Lys Arg Asp Ser Val Asn Asn Lys Trp Val
1361 1362 1362
acg tgc gcc tca gct gtc cag aaa acc acc ttt aga gta acc aga ctt 41061
Thr Cys Ala Ser Ala Val Gln Lys Thr Thr Phe Arg Val Thr Arg Leu
1363 1363 1364
cat gag ggc atg gaa tat acc ttc agg gtc agt gcc gaa aat aaa tat 41109
His Glu Gly Met Glu Tyr Thr Phe Arg Val Ser Ala Glu Asn Lys Tyr
1364 1365 1365
ggt gta ggg gaa ggc ctg aaa tcg gag cca att gtt gcg aga cat cca 41157
Gly Val Gly Glu Gly Leu Lys Ser Glu Pro Ile Val Ala Arg His Pro
1366 1366 1367 1367
ttt gat gtg cct gat gct ccc cca cct ccc aat att gtg gat gtc aga 41205
Phe Asp Val Pro Asp Ala Pro Pro Pro Pro Asn Ile Val Asp Val Arg
1368 1368 1369
cac gat tca gta tct cta act tgg act gac ccc aag aaa act ggt ggt 41253
His Asp Ser Val Ser Leu Thr Trp Thr Asp Pro Lys Lys Thr Gly Gly
1369 1370 1370
tct cca att aca ggg tat cat ctc gag ttc aag gaa aga aac agc ctt 41301
Ser Pro Ile Thr Gly Tyr His Leu Glu Phe Lys Glu Arg Asn Ser Leu
1371 1371 1372
ttg tgg aag aga gct aac aag act ccg ata agg atg aga gac ttt aaa 41349
Leu Trp Lys Arg Ala Asn Lys Thr Pro Ile Arg Met Arg Asp Phe Lys
1372 1373 1373
gtg aca gga tta act gaa ggt ctt gaa tat gaa ttc cga gtt atg gca 41397
Val Thr Gly Leu Thr Glu Gly Leu Glu Tyr Glu Phe Arg Val Met Ala
1374 1374 1375 1375
atc aat tta gca ggt gtg ggc aag cca agc cta cca tca gag cct gtt 41445
Ile Asn Leu Ala Gly Val Gly Lys Pro Ser Leu Pro Ser Glu Pro Val
1376 1376 1377
gtg gca ctg gac cca att gat cct cct gga aaa cct gag gtt att aac 41493
Val Ala Leu Asp Pro Ile Asp Pro Pro Gly Lys Pro Glu Val Ile Asn
1377 1378 1378
ata aca agg aat tca gtg act ctc att tgg act gaa cct aaa tat gac 41541
Ile Thr Arg Asn Ser Val Thr Leu Ile Trp Thr Glu Pro Lys Tyr Asp
1379 1379 1380
ggt ggt cat aag tta act gga tat ata gtg gag aag cga gat cta cct 41589
Gly Gly His Lys Leu Thr Gly Tyr Ile Val Glu Lys Arg Asp Leu Pro
1380 1381 1381
tcg aag tct tgg atg aaa gcc aac cat gtt aat gtc cca gaa tgt gcc 41637
Ser Lys Ser Trp Met Lys Ala Asn His Val Asn Val Pro Glu Cys Ala
1382 1382 1383 1383
ttt act gta act gac ctt gtt gag ggt gga aaa tat gaa ttc aga att 41685
Phe Thr Val Thr Asp Leu Val Glu Gly Gly Lys Tyr Glu Phe Arg Ile
1384 1384 1385
aga gca aag aat aca gca ggt gct atc agt gct cca tca gaa agt aca 41733
Arg Ala Lys Asn Thr Ala Gly Ala Ile Ser Ala Pro Ser Glu Ser Thr
1385 1386 1386
gaa acc att att tgc aag gat gaa tac gag gca cca aca att gtc ctt 41781
Glu Thr Ile Ile Cys Lys Asp Glu Tyr Glu Ala Pro Thr Ile Val Leu
1387 1387 1388
gat ccc aca ata aaa gat ggg cta aca att aaa gca ggg gat acc att 41829
Asp Pro Thr Ile Lys Asp Gly Leu Thr Ile Lys Ala Gly Asp Thr Ile
1388 1389 1389
gtt ttg aat gcc att agc att ctt ggc aaa ccc ctt cca aaa tca agt 41877
Val Leu Asn Ala Ile Ser Ile Leu Gly Lys Pro Leu Pro Lys Ser Ser
1390 1390 1391 1391
tgg tcc aag gca gga aaa gac att aga cca tca gat atc act cag ata 41925
Trp Ser Lys Ala Gly Lys Asp Ile Arg Pro Ser Asp Ile Thr Gln Ile
1392 1392 1393
act tca acc cca aca tct tcc atg ctt act atc aag tat gcc act aga 41973
Thr Ser Thr Pro Thr Ser Ser Met Leu Thr Ile Lys Tyr Ala Thr Arg
1393 1394 1394
aaa gat gcg ggt gaa tat acc atc act gct acc aat cct ttt ggc acg 42021
Lys Asp Ala Gly Glu Tyr Thr Ile Thr Ala Thr Asn Pro Phe Gly Thr
1395 1395 1396
aag gtg gaa cat gtg aag gta aca gtc ctt gat gta cct ggt ccc cca 42069
Lys Val Glu His Val Lys Val Thr Val Leu Asp Val Pro Gly Pro Pro
1396 1397 1397
ggt cct gtt gaa atc agt aat gtt tct gct gaa aaa gca aca ctt aca 42117
Gly Pro Val Glu Ile Ser Asn Val Ser Ala Glu Lys Ala Thr Leu Thr
1398 1398 1399 1399
tgg aca cct ccc ttg gaa gat ggc ggc tca cca att aag tcc tat ata 42165
Trp Thr Pro Pro Leu Glu Asp Gly Gly Ser Pro Ile Lys Ser Tyr Ile
1400 1400 1401
ctt gaa aag aga gaa acc agc cga ctt ttg tgg aca gtg gtt tct gaa 42213
Leu Glu Lys Arg Glu Thr Ser Arg Leu Leu Trp Thr Val Val Ser Glu
1401 1402 1402
gat att cag tct tgc agg cat gtg gca acc aaa ctt atc caa gga aat 42261
Asp Ile Gln Ser Cys Arg His Val Ala Thr Lys Leu Ile Gln Gly Asn
1403 1403 1404
gag tac atc ttc cgg gtc tca gct gta aac cac tat ggc aaa gga gaa 42309
Glu Tyr Ile Phe Arg Val Ser Ala Val Asn His Tyr Gly Lys Gly Glu
1404 1405 1405
cct gta cag tct gaa cct gtc aaa atg gta gac aga ttt ggt ccc cct 42357
Pro Val Gln Ser Glu Pro Val Lys Met Val Asp Arg Phe Gly Pro Pro
1406 1406 1407 1407
ggc cct cct gaa aaa cca gag gta tca aat gtc act aag aac act gcc 42405
Gly Pro Pro Glu Lys Pro Glu Val Ser Asn Val Thr Lys Asn Thr Ala
1408 1408 1409
act gtc agc tgg aaa agg cca gtg gat gat ggt ggc agc gaa att aca 42453
Thr Val Ser Trp Lys Arg Pro Val Asp Asp Gly Gly Ser Glu Ile Thr
1409 1410 1410
gga tat cat gta gaa agg aga gaa aag aaa agc ctg cga tgg gtg aga 42501
Gly Tyr His Val Glu Arg Arg Glu Lys Lys Ser Leu Arg Trp Val Arg
1411 1411 1412
gca ata aaa aca cca gtt tcc gat ctc agg tgc aaa gta aca gga ctg 42549
Ala Ile Lys Thr Pro Val Ser Asp Leu Arg Cys Lys Val Thr Gly Leu
1412 1413 1413
caa gaa gga agc acc tac gaa ttc cgt gtc agt gca gaa aac aga gca 42597
Gln Glu Gly Ser Thr Tyr Glu Phe Arg Val Ser Ala Glu Asn Arg Ala
1414 1414 1415 1415
gga att ggt cca ccc agt gag gct tca gat tct gtt ctg atg aaa gat 42645
Gly Ile Gly Pro Pro Ser Glu Ala Ser Asp Ser Val Leu Met Lys Asp
1416 1416 1417
gca gca tat cct cca gga cca cct tca aat ccg cat gtc act gat act 42693
Ala Ala Tyr Pro Pro Gly Pro Pro Ser Asn Pro His Val Thr Asp Thr
1417 1418 1418
acc aag aaa tct gct tct ttg gca tgg ggc aag cct cat tat gat ggt 42741
Thr Lys Lys Ser Ala Ser Leu Ala Trp Gly Lys Pro His Tyr Asp Gly
1419 1419 1420
gga ctt gaa atc act ggc tat gtc gtg gag cat caa aaa gta gga gac 42789
Gly Leu Glu Ile Thr Gly Tyr Val Val Glu His Gln Lys Val Gly Asp
1420 1421 1421
gag gcc tgg ata aaa gat acc aca gga acc gcc ctc aga atc act cag 42837
Glu Ala Trp Ile Lys Asp Thr Thr Gly Thr Ala Leu Arg Ile Thr Gln
1422 1422 1423 1423
ttc gtt gtt cct gat ctt cag act aaa gaa aaa tac aac ttc aga atc 42885
Phe Val Val Pro Asp Leu Gln Thr Lys Glu Lys Tyr Asn Phe Arg Ile
1424 1424 1425
agt gcc atc aac gat gca ggt gtt ggg gag cca gcg gtg att cca gat 42933
Ser Ala Ile Asn Asp Ala Gly Val Gly Glu Pro Ala Val Ile Pro Asp
1425 1426 1426
gtt gaa atc gta gaa cgg gag atg gct cct gat ttt gaa cta gat gcc 42981
Val Glu Ile Val Glu Arg Glu Met Ala Pro Asp Phe Glu Leu Asp Ala
1427 1427 1428
gag ctt cga aga aca ctt gtt gtt aga gca gga ctc agt att agg ata 43029
Glu Leu Arg Arg Thr Leu Val Val Arg Ala Gly Leu Ser Ile Arg Ile
1428 1429 1429
ttt gtg cca att aaa ggt cgt cct gct cct gaa gtg aca tgg acc aaa 43077
Phe Val Pro Ile Lys Gly Arg Pro Ala Pro Glu Val Thr Trp Thr Lys
1430 1430 1431 1431
gat aac atc aac ctg aaa aac cga gcc aac att gaa aat acg gaa tca 43125
Asp Asn Ile Asn Leu Lys Asn Arg Ala Asn Ile Glu Asn Thr Glu Ser
1432 1432 1433
ttt act ctt ctg att atc cca gaa tgt aac aga tat gat acc ggt aaa 43173
Phe Thr Leu Leu Ile Ile Pro Glu Cys Asn Arg Tyr Asp Thr Gly Lys
1433 1434 1434
ttt gtc atg acc att gaa aac ccg gct ggg aag aaa agt ggc ttt gtg 43221
Phe Val Met Thr Ile Glu Asn Pro Ala Gly Lys Lys Ser Gly Phe Val
1435 1435 1436
aac gtc aga gtc ttg gac acg cca ggc cca gtc ctc aac ctg cgg cct 43269
Asn Val Arg Val Leu Asp Thr Pro Gly Pro Val Leu Asn Leu Arg Pro
1436 1437 1437
aca gac atc aca aag gac agt gtc acc ctg cac tgg gac ctc cct ctg 43317
Thr Asp Ile Thr Lys Asp Ser Val Thr Leu His Trp Asp Leu Pro Leu
1438 1438 1439 1439
ata gat gga ggc tca cgt ata aca aac tac att gta gag aaa cgt gaa 43365
Ile Asp Gly Gly Ser Arg Ile Thr Asn Tyr Ile Val Glu Lys Arg Glu
1440 1440 1441
gca aca cgg aaa tct tat tcc aca gcc acc act aag tgc cat aaa tgc 43413
Ala Thr Arg Lys Ser Tyr Ser Thr Ala Thr Thr Lys Cys His Lys Cys
1441 1442 1442
aca tat aaa gtt acc ggc ttg tct gaa ggg tgt gaa tat ttc ttc aga 43461
Thr Tyr Lys Val Thr Gly Leu Ser Glu Gly Cys Glu Tyr Phe Phe Arg
1443 1443 1444
gtg atg gca gag aat gaa tat gga att ggt gag cca aca gaa act aca 43509
Val Met Ala Glu Asn Glu Tyr Gly Ile Gly Glu Pro Thr Glu Thr Thr
1444 1445 1445
gag ccc gta aaa gcc tct gaa gca cca tct cca cca gac agc ctt aac 43557
Glu Pro Val Lys Ala Ser Glu Ala Pro Ser Pro Pro Asp Ser Leu Asn
1446 1446 1447 1447
atc atg gac ata act aag agc acc gtc agc ctg gca tgg cct aag ccc 43605
Ile Met Asp Ile Thr Lys Ser Thr Val Ser Leu Ala Trp Pro Lys Pro
1448 1448 1449
aaa cac gat ggt ggc agc aag atc act ggc tat gtg att gaa gcc caa 43653
Lys His Asp Gly Gly Ser Lys Ile Thr Gly Tyr Val Ile Glu Ala Gln
1449 1450 1450
aga aaa ggc tct gac cag tgg acc cac atc aca acc gtg aaa ggg tta 43701
Arg Lys Gly Ser Asp Gln Trp Thr His Ile Thr Thr Val Lys Gly Leu
1451 1451 1452
gaa tgt gtt gtg agg aat cta act gaa gga gag gaa tat acc ttc caa 43749
Glu Cys Val Val Arg Asn Leu Thr Glu Gly Glu Glu Tyr Thr Phe Gln
1452 1453 1453
gtg atg gca gtg aac agc gcg ggg aga agt gcc cct aga gaa agc aga 43797
Val Met Ala Val Asn Ser Ala Gly Arg Ser Ala Pro Arg Glu Ser Arg
1454 1454 1455 1455
ccc gtc att gtc aag gag cag aca atg ctt cca gag ctg gat ctc cgt 43845
Pro Val Ile Val Lys Glu Gln Thr Met Leu Pro Glu Leu Asp Leu Arg
1456 1456 1457
ggc atc tat cag aaa ctg gtc att gcc aaa gct ggt gac aac atc aaa 43893
Gly Ile Tyr Gln Lys Leu Val Ile Ala Lys Ala Gly Asp Asn Ile Lys
1457 1458 1458
gtt gaa att cca gtg ctc ggt cga ccg aag ccc aca gtg aca tgg aaa 43941
Val Glu Ile Pro Val Leu Gly Arg Pro Lys Pro Thr Val Thr Trp Lys
1459 1459 1460
aaa gga gac caa att ctt aaa cag aca cag aga gtt aat ttt gaa acc 43989
Lys Gly Asp Gln Ile Leu Lys Gln Thr Gln Arg Val Asn Phe Glu Thr
1460 1461 1461
aca gcg act tca acc att tta aat atc aat gag tgt gtc aga agt gat 44037
Thr Ala Thr Ser Thr Ile Leu Asn Ile Asn Glu Cys Val Arg Ser Asp
1462 1462 1463 1463
agt ggg ccc tat cca tta aca gca agg aac att gta gga gag gtt ggt 44085
Ser Gly Pro Tyr Pro Leu Thr Ala Arg Asn Ile Val Gly Glu Val Gly
1464 1464 1465
gat gtc atc acc att caa gtc cat gat atc cca ggg cca cct act gga 44133
Asp Val Ile Thr Ile Gln Val His Asp Ile Pro Gly Pro Pro Thr Gly
1465 1466 1466
cca atc aaa ttt gat gaa gtt tca tct gat ttt gta acc ttc tct tgg 44181
Pro Ile Lys Phe Asp Glu Val Ser Ser Asp Phe Val Thr Phe Ser Trp
1467 1467 1468
gac cca cct gag aac gat ggt ggt gta cca ata agc aac tat gta gtg 44229
Asp Pro Pro Glu Asn Asp Gly Gly Val Pro Ile Ser Asn Tyr Val Val
1468 1469 1469
gaa atg cgg cag act gac agt act acc tgg gtt gag tta gca acc acc 44277
Glu Met Arg Gln Thr Asp Ser Thr Thr Trp Val Glu Leu Ala Thr Thr
1470 1470 1471 1471
gtt ata cgt act acc tat aaa gcc acc cgc ctt act act gga tta gag 44325
Val Ile Arg Thr Thr Tyr Lys Ala Thr Arg Leu Thr Thr Gly Leu Glu
1472 1472 1473
tat cag ttc cgt gta aaa gct cag aat aga tat gga gtt gga cca ggc 44373
Tyr Gln Phe Arg Val Lys Ala Gln Asn Arg Tyr Gly Val Gly Pro Gly
1473 1474 1474
atc aca tca gca tgg ata gtt gcc aac tat cca ttt aag gtt cct gga 44421
Ile Thr Ser Ala Trp Ile Val Ala Asn Tyr Pro Phe Lys Val Pro Gly
1475 1475 1476
cct cct ggt acc cct cag gta act gca gtt acc aag gat tca atg aca 44469
Pro Pro Gly Thr Pro Gln Val Thr Ala Val Thr Lys Asp Ser Met Thr
1476 1477 1477
att agc tgg cat gag cca ctt tct gat ggt gga agc ccc att tta gga 44517
Ile Ser Trp His Glu Pro Leu Ser Asp Gly Gly Ser Pro Ile Leu Gly
1478 1478 1479 1479
tat cat gtt gaa aga aaa gaa cga aat ggt att ctc tgg cag act gtg 44565
Tyr His Val Glu Arg Lys Glu Arg Asn Gly Ile Leu Trp Gln Thr Val
1480 1480 1481
agc aaa gct tta gta cca ggc aac att ttc aaa tca agt gga ctt aca 44613
Ser Lys Ala Leu Val Pro Gly Asn Ile Phe Lys Ser Ser Gly Leu Thr
1481 1482 1482
gat ggt att gct tat gag ttc cgg gtg att gca gaa aac atg gca ggc 44661
Asp Gly Ile Ala Tyr Glu Phe Arg Val Ile Ala Glu Asn Met Ala Gly
1483 1483 1484
aaa agt aag cca agc aag cca tca gaa cct atg ttg gct ctg gat ccc 44709
Lys Ser Lys Pro Ser Lys Pro Ser Glu Pro Met Leu Ala Leu Asp Pro
1484 1485 1485
att gac cca cct gga aaa cca gta cct cta aat att aca aga cac aca 44757
Ile Asp Pro Pro Gly Lys Pro Val Pro Leu Asn Ile Thr Arg His Thr
1486 1486 1487 1487
gta aca ctt aaa tgg gct aag cct gaa tat act ggg ggc ttt aaa att 44805
Val Thr Leu Lys Trp Ala Lys Pro Glu Tyr Thr Gly Gly Phe Lys Ile
1488 1488 1489
acc agt tat atc gtt gaa aag aga gac ctt cct aat gga cgg tgg ctg 44853
Thr Ser Tyr Ile Val Glu Lys Arg Asp Leu Pro Asn Gly Arg Trp Leu
1489 1490 1490
aag gcc aac ttc agc aac att ttg gag aat gaa ttt aca gtc agt ggc 44901
Lys Ala Asn Phe Ser Asn Ile Leu Glu Asn Glu Phe Thr Val Ser Gly
1491 1491 1492
cta aca gaa gat gct gca tat gaa ttc cgt gtg atc gcc aaa aat gct 44949
Leu Thr Glu Asp Ala Ala Tyr Glu Phe Arg Val Ile Ala Lys Asn Ala
1492 1493 1493
gca ggt gcc atc agt cca cca tct gag cca tct gat gct atc act tgc 44997
Ala Gly Ala Ile Ser Pro Pro Ser Glu Pro Ser Asp Ala Ile Thr Cys
1494 1494 1495 1495
agg gat gat gtt gag gca cca aag ata aag gtg gat gtt aaa ttt aag 45045
Arg Asp Asp Val Glu Ala Pro Lys Ile Lys Val Asp Val Lys Phe Lys
1496 1496 1497
gac acg gtt ata tta aaa gca ggt gaa gca ttc aga ctg gaa gct gat 45093
Asp Thr Val Ile Leu Lys Ala Gly Glu Ala Phe Arg Leu Glu Ala Asp
1497 1498 1498
gtt tca ggc cgc cca cct cca aca atg gaa tgg agc aaa gat gga aaa 45141
Val Ser Gly Arg Pro Pro Pro Thr Met Glu Trp Ser Lys Asp Gly Lys
1499 1499 1500
gag ctg gaa ggc aca gca aag tta gaa ata aaa att gca gat ttc tct 45189
Glu Leu Glu Gly Thr Ala Lys Leu Glu Ile Lys Ile Ala Asp Phe Ser
1500 1501 1501
act aat ctg gta aac aaa gat tca aca aga agg gat agt ggt gcc tat 45237
Thr Asn Leu Val Asn Lys Asp Ser Thr Arg Arg Asp Ser Gly Ala Tyr
1502 1502 1503 1503
acc ctt aca gcg act aat cct ggt ggc ttt gct aaa cac att ttc aat 45285
Thr Leu Thr Ala Thr Asn Pro Gly Gly Phe Ala Lys His Ile Phe Asn
1504 1504 1505
gtc aaa gtt ctt gac aga cca ggc cca cct gaa gga cct ttg gct gta 45333
Val Lys Val Leu Asp Arg Pro Gly Pro Pro Glu Gly Pro Leu Ala Val
1505 1506 1506
act gaa gtg aca tca gaa aag tgt gta cta tca tgg ttc cct cca ctg 45381
Thr Glu Val Thr Ser Glu Lys Cys Val Leu Ser Trp Phe Pro Pro Leu
1507 1507 1508
gat gat gga ggt gcc aaa att gat cat tac ata gta cag aaa cgt gaa 45429
Asp Asp Gly Gly Ala Lys Ile Asp His Tyr Ile Val Gln Lys Arg Glu
1508 1509 1509
acc agc aga ttg gca tgg aca aat gta gcc tca gaa gtc caa gta aca 45477
Thr Ser Arg Leu Ala Trp Thr Asn Val Ala Ser Glu Val Gln Val Thr
1510 1510 1511 1511
aag cta aag gtc act aaa ctc ttg aaa ggc aat gaa tac ata ttc cgt 45525
Lys Leu Lys Val Thr Lys Leu Leu Lys Gly Asn Glu Tyr Ile Phe Arg
1512 1512 1513
gtc atg gct gta aat aaa tat gga gtg gga gag cca ctg gaa tca gag 45573
Val Met Ala Val Asn Lys Tyr Gly Val Gly Glu Pro Leu Glu Ser Glu
1513 1514 1514
cct gtg ctt gca gtg aat cct tat gga ccc cct gat ccg ccc aaa aac 45621
Pro Val Leu Ala Val Asn Pro Tyr Gly Pro Pro Asp Pro Pro Lys Asn
1515 1515 1516
cct gaa gtg aca act att act aaa gat tcg atg gtt gtc tgc tgg gga 45669
Pro Glu Val Thr Thr Ile Thr Lys Asp Ser Met Val Val Cys Trp Gly
1516 1517 1517
cat cct gat tct gat ggt gga agt gaa atc atc aat tat att gtg gaa 45717
His Pro Asp Ser Asp Gly Gly Ser Glu Ile Ile Asn Tyr Ile Val Glu
1518 1518 1519 1519
cgg cgt gat aaa gct ggc caa cgc tgg att aaa tgc aac aaa aaa act 45765
Arg Arg Asp Lys Ala Gly Gln Arg Trp Ile Lys Cys Asn Lys Lys Thr
1520 1520 1521
ctt act gat tta aga tat aaa gtg tct gga ctg aca gaa gga cat gaa 45813
Leu Thr Asp Leu Arg Tyr Lys Val Ser Gly Leu Thr Glu Gly His Glu
1521 1522 1522
tat gag ttc agg att atg gct gaa aat gct gct gga att agt gca cca 45861
Tyr Glu Phe Arg Ile Met Ala Glu Asn Ala Ala Gly Ile Ser Ala Pro
1523 1523 1524
agt cct acc agt cca ttt tac aag gct tgt gac act gtg ttt aaa cct 45909
Ser Pro Thr Ser Pro Phe Tyr Lys Ala Cys Asp Thr Val Phe Lys Pro
1524 1525 1525
gga cca cca ggt aac cca cgt gtt ctg gat aca agc aga tca tcc att 45957
Gly Pro Pro Gly Asn Pro Arg Val Leu Asp Thr Ser Arg Ser Ser Ile
1526 1526 1527 1527
tca atc gct tgg aat aaa cct atc tat gat ggt ggt tca gaa atc act 46005
Ser Ile Ala Trp Asn Lys Pro Ile Tyr Asp Gly Gly Ser Glu Ile Thr
1528 1528 1529
ggg tat atg gtt gag att gcc ctg cca gag gaa gat gaa tgg cag att 46053
Gly Tyr Met Val Glu Ile Ala Leu Pro Glu Glu Asp Glu Trp Gln Ile
1529 1530 1530
gtc act cca cca gca gga ctc aag gca act tcg tat act atc act ggc 46101
Val Thr Pro Pro Ala Gly Leu Lys Ala Thr Ser Tyr Thr Ile Thr Gly
1531 1531 1532
ctc aca gag aat cag gaa tat aag atc cgc atc tat gcc atg aat tcc 46149
Leu Thr Glu Asn Gln Glu Tyr Lys Ile Arg Ile Tyr Ala Met Asn Ser
1532 1533 1533
gaa gga ctt ggg gaa cct gcc ctt gtt cct gga act cca aag gct gaa 46197
Glu Gly Leu Gly Glu Pro Ala Leu Val Pro Gly Thr Pro Lys Ala Glu
1534 1534 1535 1535
gac aga atg ctg cct cca gaa att gaa ctg gat gct gac ctg cgc aaa 46245
Asp Arg Met Leu Pro Pro Glu Ile Glu Leu Asp Ala Asp Leu Arg Lys
1536 1536 1537
gtt gtt act ata agg gcc tgc tgc acc ctg aga ctt ttt gtt ccc atc 46293
Val Val Thr Ile Arg Ala Cys Cys Thr Leu Arg Leu Phe Val Pro Ile
1537 1538 1538
aaa gga agg cct gac cct gag gtg aag tgg gcc cgg gac cat gga gaa 46341
Lys Gly Arg Pro Asp Pro Glu Val Lys Trp Ala Arg Asp His Gly Glu
1539 1539 1540
tct tta gat aaa gct agc atc gaa tcc gca agc tct tac acc ctg ctt 46389
Ser Leu Asp Lys Ala Ser Ile Glu Ser Ala Ser Ser Tyr Thr Leu Leu
1540 1541 1541
att gtt gga aat gta aac aga ttt gac agt ggc aaa tat ata cta act 46437
Ile Val Gly Asn Val Asn Arg Phe Asp Ser Gly Lys Tyr Ile Leu Thr
1542 1542 1543 1543
gta gaa aat agt tca ggc agc aag tct gca ttt gtc aat gtt aga gtt 46485
Val Glu Asn Ser Ser Gly Ser Lys Ser Ala Phe Val Asn Val Arg Val
1544 1544 1545
ctc gat aca cca ggc ccc cca cag gat ctg aag gta aaa gag gtc act 46533
Leu Asp Thr Pro Gly Pro Pro Gln Asp Leu Lys Val Lys Glu Val Thr
1545 1546 1546
aag aca tct gtc aca ctc aca tgg gac cca cct ctc ctt gat gga ggt 46581
Lys Thr Ser Val Thr Leu Thr Trp Asp Pro Pro Leu Leu Asp Gly Gly
1547 1547 1548
tca aaa atc aag aac tat att gtt gaa aag cgg gaa tca aca aga aaa 46629
Ser Lys Ile Lys Asn Tyr Ile Val Glu Lys Arg Glu Ser Thr Arg Lys
1548 1549 1549
gca tat tca act gtt gca aca aac tgc cac aag act tcc tgg aag gta 46677
Ala Tyr Ser Thr Val Ala Thr Asn Cys His Lys Thr Ser Trp Lys Val
1550 1550 1551 1551
gac cag ctt caa gaa ggc tgt agc tac tat ttc agg gtt ctc gca gaa 46725
Asp Gln Leu Gln Glu Gly Cys Ser Tyr Tyr Phe Arg Val Leu Ala Glu
1552 1552 1553
aat gaa tat ggc att ggg ctg cct gct gaa acc gca gaa tct gtg aaa 46773
Asn Glu Tyr Gly Ile Gly Leu Pro Ala Glu Thr Ala Glu Ser Val Lys
1553 1554 1554
gca tca gaa cga cct ctt cct cca gga aaa ata act ttg atg gat gtc 46821
Ala Ser Glu Arg Pro Leu Pro Pro Gly Lys Ile Thr Leu Met Asp Val
1555 1555 1556
aca aga aat agt gtg tca ctc tct tgg gag aaa cca gag cat gat gga 46869
Thr Arg Asn Ser Val Ser Leu Ser Trp Glu Lys Pro Glu His Asp Gly
1556 1557 1557
ggc agc cga att cta ggc tac att gtg gag atg cag acc aaa ggc agt 46917
Gly Ser Arg Ile Leu Gly Tyr Ile Val Glu Met Gln Thr Lys Gly Ser
1558 1558 1559 1559
gac aaa tgg gcc acg tgt gcc aca gtc aag gtc act gaa gcc act atc 46965
Asp Lys Trp Ala Thr Cys Ala Thr Val Lys Val Thr Glu Ala Thr Ile
1560 1560 1561
act gga tta att cag ggt gaa gaa tac tct ttc cgt gtt tca gct cag 47013
Thr Gly Leu Ile Gln Gly Glu Glu Tyr Ser Phe Arg Val Ser Ala Gln
1561 1562 1562
aat gaa aag ggc atc agt gat cct aga caa ctg agt gtg cca gtg atc 47061
Asn Glu Lys Gly Ile Ser Asp Pro Arg Gln Leu Ser Val Pro Val Ile
1563 1563 1564
gcc aaa gat ctt gtc att cca cca gcc ttc aaa ctc ctg ttc aat act 47109
Ala Lys Asp Leu Val Ile Pro Pro Ala Phe Lys Leu Leu Phe Asn Thr
1564 1565 1565
ttc act gta ctg gca ggt gaa gac cta aaa gtt gat gtt cca ttc att 47157
Phe Thr Val Leu Ala Gly Glu Asp Leu Lys Val Asp Val Pro Phe Ile
1566 1566 1567 1567
ggc cgc cct acc cca gct gta acc tgg cat aaa gat aat gta cca ctg 47205
Gly Arg Pro Thr Pro Ala Val Thr Trp His Lys Asp Asn Val Pro Leu
1568 1568 1569
aag cag aca act aga gta aat gca gag agc aca gaa aat aat tca cta 47253
Lys Gln Thr Thr Arg Val Asn Ala Glu Ser Thr Glu Asn Asn Ser Leu
1569 1570 1570
ctg aca ata aag gac gcc tgc cga gaa gat gtt ggc cat tat gtg gtt 47301
Leu Thr Ile Lys Asp Ala Cys Arg Glu Asp Val Gly His Tyr Val Val
1571 1571 1572
aaa ctg act aac tca gct ggt gaa gct att gaa acc ctt aat gtt atc 47349
Lys Leu Thr Asn Ser Ala Gly Glu Ala Ile Glu Thr Leu Asn Val Ile
1572 1573 1573
gtt ctt gac aaa cca ggg cct cca act gga cca gtt aaa atg gat gaa 47397
Val Leu Asp Lys Pro Gly Pro Pro Thr Gly Pro Val Lys Met Asp Glu
1574 1574 1575 1575
gtg aca gct gat agt att act ctt tcc tgg ggc cca ccc aag tat gat 47445
Val Thr Ala Asp Ser Ile Thr Leu Ser Trp Gly Pro Pro Lys Tyr Asp
1576 1576 1577
ggc gga agt tct atc aat aat tac att gtt gag aaa cgg gac act tcc 47493
Gly Gly Ser Ser Ile Asn Asn Tyr Ile Val Glu Lys Arg Asp Thr Ser
1577 1578 1578
aca acc acc tgg caa att gta tca gct aca gtt gca agg aca aca ata 47541
Thr Thr Thr Trp Gln Ile Val Ser Ala Thr Val Ala Arg Thr Thr Ile
1579 1579 1580
aag gct tgc aga ctg aag act gga tgt gaa tat cag ttt aga att gca 47589
Lys Ala Cys Arg Leu Lys Thr Gly Cys Glu Tyr Gln Phe Arg Ile Ala
1580 1581 1581
gct gaa aac aga tat ggg aag agt acc tac ctc aat tca gag cct act 47637
Ala Glu Asn Arg Tyr Gly Lys Ser Thr Tyr Leu Asn Ser Glu Pro Thr
1582 1582 1583 1583
gta gcc caa tat cca ttc aaa gtt cct ggt cct cct ggc act cca gtt 47685
Val Ala Gln Tyr Pro Phe Lys Val Pro Gly Pro Pro Gly Thr Pro Val
1584 1584 1585
gtc aca ctg tcc tcc agg gac agc atg gaa gta caa tgg aat gag cca 47733
Val Thr Leu Ser Ser Arg Asp Ser Met Glu Val Gln Trp Asn Glu Pro
1585 1586 1586
atc agt gat gga gga agt aga gtc att ggc tat cat cta gaa cgc aag 47781
Ile Ser Asp Gly Gly Ser Arg Val Ile Gly Tyr His Leu Glu Arg Lys
1587 1587 1588
gaa aga aat agc atc ctc tgg gtt aag ttg aat aaa aca cct att cct 47829
Glu Arg Asn Ser Ile Leu Trp Val Lys Leu Asn Lys Thr Pro Ile Pro
1588 1589 1589
caa acc aag ttt aag aca act ggc ctt gaa gaa ggt gtt gaa tat gaa 47877
Gln Thr Lys Phe Lys Thr Thr Gly Leu Glu Glu Gly Val Glu Tyr Glu
1590 1590 1591 1591
ttt aga gtc tct gca gag aac atc gtg ggc att ggc aag ccg agt aaa 47925
Phe Arg Val Ser Ala Glu Asn Ile Val Gly Ile Gly Lys Pro Ser Lys
1592 1592 1593
gta tca gaa tgt tat gtg gct cgt gac cca tgt gat cca cca gga cgg 47973
Val Ser Glu Cys Tyr Val Ala Arg Asp Pro Cys Asp Pro Pro Gly Arg
1593 1594 1594
cca gag gca atc att gtc aca agg aat tct gtg act ctt cag tgg aag 48021
Pro Glu Ala Ile Ile Val Thr Arg Asn Ser Val Thr Leu Gln Trp Lys
1595 1595 1596
aaa ccc acc tat gac ggt gga agc aag atc act ggt tat att gtt gag 48069
Lys Pro Thr Tyr Asp Gly Gly Ser Lys Ile Thr Gly Tyr Ile Val Glu
1596 1597 1597
aag aaa gaa tta cct gag ggc cgt tgg atg aaa gcc agt ttt aca aat 48117
Lys Lys Glu Leu Pro Glu Gly Arg Trp Met Lys Ala Ser Phe Thr Asn
1598 1598 1599 1599
att att gac act cat ttt gaa gta act ggc cta gtt gaa gat cac aga 48165
Ile Ile Asp Thr His Phe Glu Val Thr Gly Leu Val Glu Asp His Arg
1600 1600 1601
tat gag ttc cgg gtt ata gcc cga aat gcc gca gga gtg ttt agt gag 48213
Tyr Glu Phe Arg Val Ile Ala Arg Asn Ala Ala Gly Val Phe Ser Glu
1601 1602 1602
cct tca gaa agc aca gga gca ata aca gct aga gat gag gta gat cca 48261
Pro Ser Glu Ser Thr Gly Ala Ile Thr Ala Arg Asp Glu Val Asp Pro
1603 1603 1604
cca cga ata agt atg gat cca aaa tac aaa gac aca atc gtg gtt cat 48309
Pro Arg Ile Ser Met Asp Pro Lys Tyr Lys Asp Thr Ile Val Val His
1604 1605 1605
gct ggt gaa tca ttc aag gtt gat gca gat att tat ggc aaa cca ata 48357
Ala Gly Glu Ser Phe Lys Val Asp Ala Asp Ile Tyr Gly Lys Pro Ile
1606 1606 1607 1607
cca acc att cag tgg ata aaa ggt gat cag gag ctt tca aac aca gct 48405
Pro Thr Ile Gln Trp Ile Lys Gly Asp Gln Glu Leu Ser Asn Thr Ala
1608 1608 1609
cga tta gaa ata aag agc acc gac ttt gcc acc agt ctc agt gta aaa 48453
Arg Leu Glu Ile Lys Ser Thr Asp Phe Ala Thr Ser Leu Ser Val Lys
1609 1610 1610
gat gca gta cgt gtc gac agt gga aat tac ata ctg aag gcc aaa aat 48501
Asp Ala Val Arg Val Asp Ser Gly Asn Tyr Ile Leu Lys Ala Lys Asn
1611 1611 1612
gtt gca gga gaa aga tca gtt act gtg aat gtc aag gtt ctt gac aga 48549
Val Ala Gly Glu Arg Ser Val Thr Val Asn Val Lys Val Leu Asp Arg
1612 1613 1613
cca ggg cca cct gaa gga cct gtt gtt atc tca gga gtt aca gca gaa 48597
Pro Gly Pro Pro Glu Gly Pro Val Val Ile Ser Gly Val Thr Ala Glu
1614 1614 1615 1615
aaa tgc aca cta gct tgg aaa ccc cca ctt cag gat ggt ggg agt gac 48645
Lys Cys Thr Leu Ala Trp Lys Pro Pro Leu Gln Asp Gly Gly Ser Asp
1616 1616 1617
atc ata aat tat att gtg gaa agg aga gaa acc agc cgc tta gtt tgg 48693
Ile Ile Asn Tyr Ile Val Glu Arg Arg Glu Thr Ser Arg Leu Val Trp
1617 1618 1618
act gtg gtt gat gcc aat gtg cag act ctc agc tgc aag gtt act aag 48741
Thr Val Val Asp Ala Asn Val Gln Thr Leu Ser Cys Lys Val Thr Lys
1619 1619 1620
ctt ctt gaa ggc aat gaa tat act ttc cgt ata atg gca gta aac aaa 48789
Leu Leu Glu Gly Asn Glu Tyr Thr Phe Arg Ile Met Ala Val Asn Lys
1620 1621 1621
tat ggt gtt ggt gaa cct ctt gaa tct gag cca gta gtt gcc aag aat 48837
Tyr Gly Val Gly Glu Pro Leu Glu Ser Glu Pro Val Val Ala Lys Asn
1622 1622 1623 1623
cca ttt gta gta cca gat gca cca aaa gct cca gaa gtc aca aca gtg 48885
Pro Phe Val Val Pro Asp Ala Pro Lys Ala Pro Glu Val Thr Thr Val
1624 1624 1625
acc aag gac tca atg att gtt gta tgg gaa aga cca gca tct gat ggt 48933
Thr Lys Asp Ser Met Ile Val Val Trp Glu Arg Pro Ala Ser Asp Gly
1625 1626 1626
ggt agt gaa att ctt gga tat gtt ctt gag aaa cgg gat aaa gaa ggc 48981
Gly Ser Glu Ile Leu Gly Tyr Val Leu Glu Lys Arg Asp Lys Glu Gly
1627 1627 1628
att aga tgg aca aga tgc cat aag cgt ctg att gga gag ttg cgc ctg 49029
Ile Arg Trp Thr Arg Cys His Lys Arg Leu Ile Gly Glu Leu Arg Leu
1628 1629 1629
aga gta act gga ctc ata gaa aat cac gat tat gag ttc aga gtt tct 49077
Arg Val Thr Gly Leu Ile Glu Asn His Asp Tyr Glu Phe Arg Val Ser
1630 1630 1631 1631
gct gag aat gct gct gga ctt agt gaa cca agc cct cct tct gct tac 49125
Ala Glu Asn Ala Ala Gly Leu Ser Glu Pro Ser Pro Pro Ser Ala Tyr
1632 1632 1633
caa aag gct tgt gat cct att tat aaa cca gga ccc cca aac aac ccc 49173
Gln Lys Ala Cys Asp Pro Ile Tyr Lys Pro Gly Pro Pro Asn Asn Pro
1633 1634 1634
aaa gtc ata gac ata acc aga tct tca gta ttc ctt tct tgg agc aaa 49221
Lys Val Ile Asp Ile Thr Arg Ser Ser Val Phe Leu Ser Trp Ser Lys
1635 1635 1636
cca ata tat gat ggt ggc tgt gaa att caa gga tac att gtt gaa aaa 49269
Pro Ile Tyr Asp Gly Gly Cys Glu Ile Gln Gly Tyr Ile Val Glu Lys
1636 1637 1637
tgt gat gtg aat gtt ggt gaa tgg aca atg tgc act cca cca aca gga 49317
Cys Asp Val Asn Val Gly Glu Trp Thr Met Cys Thr Pro Pro Thr Gly
1638 1638 1639 1639
att aat aaa aca aac ata gaa gta gag aag ctg ttg gaa aag cat gaa 49365
Ile Asn Lys Thr Asn Ile Glu Val Glu Lys Leu Leu Glu Lys His Glu
1640 1640 1641
tac aac ttc cgt atc tgt gct att aat aaa gct gga gtt gga gaa cat 49413
Tyr Asn Phe Arg Ile Cys Ala Ile Asn Lys Ala Gly Val Gly Glu His
1641 1642 1642
gct gac gtc cct gga cct att ata gtt gaa gaa aaa tta gaa gca cca 49461
Ala Asp Val Pro Gly Pro Ile Ile Val Glu Glu Lys Leu Glu Ala Pro
1643 1643 1644
gac att gat ctt gac cta gaa cta agg aaa atc ata aat ata agg gca 49509
Asp Ile Asp Leu Asp Leu Glu Leu Arg Lys Ile Ile Asn Ile Arg Ala
1644 1645 1645
ggt ggc tcc tta agg tta ttt gtt cct ata aaa ggt cgt cct aca cca 49557
Gly Gly Ser Leu Arg Leu Phe Val Pro Ile Lys Gly Arg Pro Thr Pro
1646 1646 1647 1647
gaa gtt aaa tgg gga aag gtg gat ggt gaa atc cga gat gca gct ata 49605
Glu Val Lys Trp Gly Lys Val Asp Gly Glu Ile Arg Asp Ala Ala Ile
1648 1648 1649
att gat gtc act agc agt ttc acc tct ctt gtt ctt gac aat gtc aac 49653
Ile Asp Val Thr Ser Ser Phe Thr Ser Leu Val Leu Asp Asn Val Asn
1649 1650 1650
cga tat gat agt gga aaa tat acg ctt aca tta gaa aac agc agt gga 49701
Arg Tyr Asp Ser Gly Lys Tyr Thr Leu Thr Leu Glu Asn Ser Ser Gly
1651 1651 1652
aca aag tct gcc ttt gtt act gtg aga gtt ctg gac acg cca agt cca 49749
Thr Lys Ser Ala Phe Val Thr Val Arg Val Leu Asp Thr Pro Ser Pro
1652 1653 1653
cct gtt aac ctg aaa gtc aca gaa atc acc aaa gac tca gta tca att 49797
Pro Val Asn Leu Lys Val Thr Glu Ile Thr Lys Asp Ser Val Ser Ile
1654 1654 1655 1655
aca tgg gaa cct cct ttg ttg gat ggg gga tcc aaa ata aaa aat tac 49845
Thr Trp Glu Pro Pro Leu Leu Asp Gly Gly Ser Lys Ile Lys Asn Tyr
1656 1656 1657
att gtt gag aaa cgt gaa gcc aca aga aaa tca tat gct gct gtt gta 49893
Ile Val Glu Lys Arg Glu Ala Thr Arg Lys Ser Tyr Ala Ala Val Val
1657 1658 1658
act aac tgc cat aag aat tct tgg aaa atc gat cag ctc caa gaa ggt 49941
Thr Asn Cys His Lys Asn Ser Trp Lys Ile Asp Gln Leu Gln Glu Gly
1659 1659 1660
tgc agt tat tac ttt aga gtc aca gct gag aat gag tat ggt att ggc 49989
Cys Ser Tyr Tyr Phe Arg Val Thr Ala Glu Asn Glu Tyr Gly Ile Gly
1660 1661 1661
ctt cct gcc cag act gct gat cca att aag gtt gca gaa gtg cca caa 50037
Leu Pro Ala Gln Thr Ala Asp Pro Ile Lys Val Ala Glu Val Pro Gln
1662 1662 1663 1663
cct cct gga aaa ata act gtg gat gat gtc acc aga aac agt gtc tct 50085
Pro Pro Gly Lys Ile Thr Val Asp Asp Val Thr Arg Asn Ser Val Ser
1664 1664 1665
ctg agt tgg aca aaa cct gaa cat gat ggt ggc agt aaa atc att cag 50133
Leu Ser Trp Thr Lys Pro Glu His Asp Gly Gly Ser Lys Ile Ile Gln
1665 1666 1666
tat att gtg gaa atg caa gct aaa cac agt gag aaa tgg tca gag tgt 50181
Tyr Ile Val Glu Met Gln Ala Lys His Ser Glu Lys Trp Ser Glu Cys
1667 1667 1668
gct cga gta aag tct ctt cag gca gta att acc aac cta act caa ggg 50229
Ala Arg Val Lys Ser Leu Gln Ala Val Ile Thr Asn Leu Thr Gln Gly
1668 1669 1669
gaa gaa tat ctt ttt aga gtt gtt gct gta aat gaa aag ggg aga agt 50277
Glu Glu Tyr Leu Phe Arg Val Val Ala Val Asn Glu Lys Gly Arg Ser
1670 1670 1671 1671
gat cct cgg tcc ctt gca gtt cca ata gtt gcc aaa gat ctg gta att 50325
Asp Pro Arg Ser Leu Ala Val Pro Ile Val Ala Lys Asp Leu Val Ile
1672 1672 1673
gag cca gat gta aaa cct gca ttc agt agt tac agt gta cag gtt ggc 50373
Glu Pro Asp Val Lys Pro Ala Phe Ser Ser Tyr Ser Val Gln Val Gly
1673 1674 1674
caa gat ttg aaa atg gaa gtg cca att tct gga cgt cct aag cca acc 50421
Gln Asp Leu Lys Met Glu Val Pro Ile Ser Gly Arg Pro Lys Pro Thr
1675 1675 1676
att acc tgg act aaa gat ggt ctc cca ctg aag cag acc aca aga atc 50469
Ile Thr Trp Thr Lys Asp Gly Leu Pro Leu Lys Gln Thr Thr Arg Ile
1676 1677 1677
aat gtt acc gat tca ctg gat ctc acc aca ctc agt att aaa gaa act 50517
Asn Val Thr Asp Ser Leu Asp Leu Thr Thr Leu Ser Ile Lys Glu Thr
1678 1678 1679 1679
cat aag gat gat ggt gga caa tat gga atc aca gtt gcc aat gtt gtt 50565
His Lys Asp Asp Gly Gly Gln Tyr Gly Ile Thr Val Ala Asn Val Val
1680 1680 1681
ggt cag aag aca gca tcc atc gaa att gta act cta gat aaa cct gat 50613
Gly Gln Lys Thr Ala Ser Ile Glu Ile Val Thr Leu Asp Lys Pro Asp
1681 1682 1682
cct cca aaa gga cct gtt aaa ttt gat gac gtc agt gct gaa agt att 50661
Pro Pro Lys Gly Pro Val Lys Phe Asp Asp Val Ser Ala Glu Ser Ile
1683 1683 1684
aca tta tct tgg aac cct cca tta tat aca ggg ggc tgc caa atc acc 50709
Thr Leu Ser Trp Asn Pro Pro Leu Tyr Thr Gly Gly Cys Gln Ile Thr
1684 1685 1685
aac tac att gtt cag aaa aga gat aca acc acc aca gta tgg gat gtt 50757
Asn Tyr Ile Val Gln Lys Arg Asp Thr Thr Thr Thr Val Trp Asp Val
1686 1686 1687 1687
gtt tct gct act gtt gct aga act aca ctc aaa gtg acc aaa ctg aaa 50805
Val Ser Ala Thr Val Ala Arg Thr Thr Leu Lys Val Thr Lys Leu Lys
1688 1688 1689
act ggt aca gaa tac caa ttt aga ata ttt gcc gaa aac aga tat gga 50853
Thr Gly Thr Glu Tyr Gln Phe Arg Ile Phe Ala Glu Asn Arg Tyr Gly
1689 1690 1690
caa agc ttt gcc tta gag tct gat cca att gta gct caa tat ccc tac 50901
Gln Ser Phe Ala Leu Glu Ser Asp Pro Ile Val Ala Gln Tyr Pro Tyr
1691 1691 1692
aaa gaa cca ggc cct cca ggt aca cca ttt gcc aca gcc att tcc aaa 50949
Lys Glu Pro Gly Pro Pro Gly Thr Pro Phe Ala Thr Ala Ile Ser Lys
1692 1693 1693
gac tcc atg gtc ata cag tgg cat gaa cca gtc aac aat ggt gga agc 50997
Asp Ser Met Val Ile Gln Trp His Glu Pro Val Asn Asn Gly Gly Ser
1694 1694 1695 1695
ccc gtc ata ggt tac cac ctg gag aga aaa gaa aga aac agt att ttg 51045
Pro Val Ile Gly Tyr His Leu Glu Arg Lys Glu Arg Asn Ser Ile Leu
1696 1696 1697
tgg aca aag gtc aac aaa act att att cat gac acc caa ttc aaa gca 51093
Trp Thr Lys Val Asn Lys Thr Ile Ile His Asp Thr Gln Phe Lys Ala
1697 1698 1698
cag aat ctt gaa gaa ggc att gaa tat gaa ttc aga gtg tat gct gaa 51141
Gln Asn Leu Glu Glu Gly Ile Glu Tyr Glu Phe Arg Val Tyr Ala Glu
1699 1699 1700
aat att gtt ggt gta ggc aaa gca agc aag aat tct gaa tgc tat gta 51189
Asn Ile Val Gly Val Gly Lys Ala Ser Lys Asn Ser Glu Cys Tyr Val
1700 1701 1701
gcc aga gat ccc tgt gac cca cca gga acc cca gaa cca ata atg gtt 51237
Ala Arg Asp Pro Cys Asp Pro Pro Gly Thr Pro Glu Pro Ile Met Val
1702 1702 1703 1703
aaa aga aat gaa atc act tta cag tgg acc aaa cct gtg tat gat ggt 51285
Lys Arg Asn Glu Ile Thr Leu Gln Trp Thr Lys Pro Val Tyr Asp Gly
1704 1704 1705
gga agt atg att aca ggc tac att gta gag aaa cgt gat ttg cct gat 51333
Gly Ser Met Ile Thr Gly Tyr Ile Val Glu Lys Arg Asp Leu Pro Asp
1705 1706 1706
ggt cgt tgg atg aaa gct agc ttt aca aat gtc att gaa act caa ttt 51381
Gly Arg Trp Met Lys Ala Ser Phe Thr Asn Val Ile Glu Thr Gln Phe
1707 1707 1708
act gtg tca ggt ctt act gaa gat caa aga tat gaa ttc aga gtc att 51429
Thr Val Ser Gly Leu Thr Glu Asp Gln Arg Tyr Glu Phe Arg Val Ile
1708 1709 1709
gca aag aat gca gct ggt gca ata agt aaa ccc tct gac agt act gga 51477
Ala Lys Asn Ala Ala Gly Ala Ile Ser Lys Pro Ser Asp Ser Thr Gly
1710 1710 1711 1711
cca ata act gcc aag gat gag gtt gaa ctc cca aga att tca atg gat 51525
Pro Ile Thr Ala Lys Asp Glu Val Glu Leu Pro Arg Ile Ser Met Asp
1712 1712 1713
cca aaa ttc aga gac aca att gtg gta aat gct gga gaa aca ttc aga 51573
Pro Lys Phe Arg Asp Thr Ile Val Val Asn Ala Gly Glu Thr Phe Arg
1713 1714 1714
ctt gag gct gat gtc cat gga aag ccc cta cct acc att gag tgg tta 51621
Leu Glu Ala Asp Val His Gly Lys Pro Leu Pro Thr Ile Glu Trp Leu
1715 1715 1716
aga gga gat aag gaa att gaa gaa tct gct aga tgt gaa ata aag aac 51669
Arg Gly Asp Lys Glu Ile Glu Glu Ser Ala Arg Cys Glu Ile Lys Asn
1716 1717 1717
aca gat ttc aag gct tta ctt att gta aaa gat gca att aga att gat 51717
Thr Asp Phe Lys Ala Leu Leu Ile Val Lys Asp Ala Ile Arg Ile Asp
1718 1718 1719 1719
ggt ggg cag tat att tta aga gct tcc aat gtt gca ggt tct aag tca 51765
Gly Gly Gln Tyr Ile Leu Arg Ala Ser Asn Val Ala Gly Ser Lys Ser
1720 1720 1721
ttc cca gta aat gta aaa gta tta gat aga cca gga cct cca gaa ggg 51813
Phe Pro Val Asn Val Lys Val Leu Asp Arg Pro Gly Pro Pro Glu Gly
1721 1722 1722
cca gtc cag gtt act gga gtc act tct gaa aaa tgc tct tta aca tgg 51861
Pro Val Gln Val Thr Gly Val Thr Ser Glu Lys Cys Ser Leu Thr Trp
1723 1723 1724
tct cca cca ctt caa gat ggt ggc agt gac att tct cac tat gtt gtt 51909
Ser Pro Pro Leu Gln Asp Gly Gly Ser Asp Ile Ser His Tyr Val Val
1724 1725 1725
gaa aag cga gaa acc agt cga ctt gcc tgg act gtt gtt gct tca gaa 51957
Glu Lys Arg Glu Thr Ser Arg Leu Ala Trp Thr Val Val Ala Ser Glu
1726 1726 1727 1727
gtt gtg acc aat tct ctg aaa gtt acc aaa ctc tta gaa ggt aat gaa 52005
Val Val Thr Asn Ser Leu Lys Val Thr Lys Leu Leu Glu Gly Asn Glu
1728 1728 1729
tat gtt ttc cgt ata atg gct gtc aac aaa tat ggt gtt gga gag cct 52053
Tyr Val Phe Arg Ile Met Ala Val Asn Lys Tyr Gly Val Gly Glu Pro
1729 1730 1730
ttg gaa tct gca cca gta cta atg aaa aat cca ttt gtg ctt cct gga 52101
Leu Glu Ser Ala Pro Val Leu Met Lys Asn Pro Phe Val Leu Pro Gly
1731 1731 1732
cca cca aaa agc ttg gaa gtc aca aat att gcc aaa gac tcc atg acc 52149
Pro Pro Lys Ser Leu Glu Val Thr Asn Ile Ala Lys Asp Ser Met Thr
1732 1733 1733
gtc tgt tgg aac cgt cca gat agt gat ggt gga agt gag att att ggt 52197
Val Cys Trp Asn Arg Pro Asp Ser Asp Gly Gly Ser Glu Ile Ile Gly
1734 1734 1735 1735
tac att gta gag aaa aga gac aga agt ggc att cga tgg ata aaa tgt 52245
Tyr Ile Val Glu Lys Arg Asp Arg Ser Gly Ile Arg Trp Ile Lys Cys
1736 1736 1737
aat aaa cgc cgc att aca gat ttg cgt cta aga gtg aca gga tta aca 52293
Asn Lys Arg Arg Ile Thr Asp Leu Arg Leu Arg Val Thr Gly Leu Thr
1737 1738 1738
gaa gat cat gag tat gaa ttc agg gtc tct gca gaa aat gct gct gga 52341
Glu Asp His Glu Tyr Glu Phe Arg Val Ser Ala Glu Asn Ala Ala Gly
1739 1739 1740
gtt ggg gaa cca agt cca gct aca gtt tat tat aaa gcc tgt gat cct 52389
Val Gly Glu Pro Ser Pro Ala Thr Val Tyr Tyr Lys Ala Cys Asp Pro
1740 1741 1741
gtg ttc aaa cct ggc cca cct acc aat gca cac att gta gac acc act 52437
Val Phe Lys Pro Gly Pro Pro Thr Asn Ala His Ile Val Asp Thr Thr
1742 1742 1743 1743
aaa aat tca atc aca ctt gcc tgg ggt aaa ccc atc tat gat ggc ggc 52485
Lys Asn Ser Ile Thr Leu Ala Trp Gly Lys Pro Ile Tyr Asp Gly Gly
1744 1744 1745
agt gag atc ttg gga tat gta gta gaa atc tgt aaa gca gat gaa gaa 52533
Ser Glu Ile Leu Gly Tyr Val Val Glu Ile Cys Lys Ala Asp Glu Glu
1745 1746 1746
gaa tgg caa ata gtt act cca cag act ggc ctg aga gtc act cga ttt 52581
Glu Trp Gln Ile Val Thr Pro Gln Thr Gly Leu Arg Val Thr Arg Phe
1747 1747 1748
gaa att tca aaa ctc act gaa cac caa gag tat aaa ata cga gtc tgt 52629
Glu Ile Ser Lys Leu Thr Glu His Gln Glu Tyr Lys Ile Arg Val Cys
1748 1749 1749
gcc ctc aac aaa gtt ggt tta ggt gag gct aca tca gtt cct ggt act 52677
Ala Leu Asn Lys Val Gly Leu Gly Glu Ala Thr Ser Val Pro Gly Thr
1750 1750 1751 1751
gtg aaa cca gaa gat aaa ctt gaa gca cct gaa ctt gac ctt gac tcc 52725
Val Lys Pro Glu Asp Lys Leu Glu Ala Pro Glu Leu Asp Leu Asp Ser
1752 1752 1753
gaa tta aga aaa gga att gtt gta aga gct ggt gga tct gcc aga att 52773
Glu Leu Arg Lys Gly Ile Val Val Arg Ala Gly Gly Ser Ala Arg Ile
1753 1754 1754
cac att cca ttc aaa ggt cgt cca atg cct gag atc act tgg tct cga 52821
His Ile Pro Phe Lys Gly Arg Pro Met Pro Glu Ile Thr Trp Ser Arg
1755 1755 1756
gag gaa ggt gaa ttc aca gat aag gtc caa att gaa aag gga gta aac 52869
Glu Glu Gly Glu Phe Thr Asp Lys Val Gln Ile Glu Lys Gly Val Asn
1756 1757 1757
tat acc caa cta tca ata gat aac tgt gat aga aat gat gct gga aaa 52917
Tyr Thr Gln Leu Ser Ile Asp Asn Cys Asp Arg Asn Asp Ala Gly Lys
1758 1758 1759 1759
tac att ctt aag ttg gaa aac agc agt gga tca aag tct gct ttt gta 52965
Tyr Ile Leu Lys Leu Glu Asn Ser Ser Gly Ser Lys Ser Ala Phe Val
1760 1760 1761
act gtg aaa gtt ctt gac act cca gga cca cca cag aat ttg gca gtc 53013
Thr Val Lys Val Leu Asp Thr Pro Gly Pro Pro Gln Asn Leu Ala Val
1761 1762 1762
aaa gaa gtg aga aaa gat tct gcc ttc ctg gta tgg gag cca ccc atc 53061
Lys Glu Val Arg Lys Asp Ser Ala Phe Leu Val Trp Glu Pro Pro Ile
1763 1763 1764
att gat gga ggg gca aag gtc aag aac tat gtg att gac aaa cgt gag 53109
Ile Asp Gly Gly Ala Lys Val Lys Asn Tyr Val Ile Asp Lys Arg Glu
1764 1765 1765
tca acc aga aaa gcg tat gct aat gtg agt agt aaa tgc agc aaa aca 53157
Ser Thr Arg Lys Ala Tyr Ala Asn Val Ser Ser Lys Cys Ser Lys Thr
1766 1766 1767 1767
agt ttt aaa gtg gaa aac ctt aca gaa gga gcc att tat tac ttc aga 53205
Ser Phe Lys Val Glu Asn Leu Thr Glu Gly Ala Ile Tyr Tyr Phe Arg
1768 1768 1769
gtc atg gct gaa aat gaa ttt gga gtt ggt gtt cca gtg gaa act gtt 53253
Val Met Ala Glu Asn Glu Phe Gly Val Gly Val Pro Val Glu Thr Val
1769 1770 1770
gat gcc gtg aaa gct gct gaa cct cct tcc cca cca gga aag gtt aca 53301
Asp Ala Val Lys Ala Ala Glu Pro Pro Ser Pro Pro Gly Lys Val Thr
1771 1771 1772
ctc act gat gtg tcc cag acc agt gca tca ctt atg tgg gag aaa cct 53349
Leu Thr Asp Val Ser Gln Thr Ser Ala Ser Leu Met Trp Glu Lys Pro
1772 1773 1773
gaa cat gat ggc ggt agc aga gtc ctg ggg tac gtt gtt gaa atg cag 53397
Glu His Asp Gly Gly Ser Arg Val Leu Gly Tyr Val Val Glu Met Gln
1774 1774 1775 1775
ccc aaa gga act gaa aaa tgg agc att gtg gct gaa tcc aaa gtc tgt 53445
Pro Lys Gly Thr Glu Lys Trp Ser Ile Val Ala Glu Ser Lys Val Cys
1776 1776 1777
aat gca gtt gtt act ggt ttg agt tct gga caa gaa tat cag ttc cgt 53493
Asn Ala Val Val Thr Gly Leu Ser Ser Gly Gln Glu Tyr Gln Phe Arg
1777 1778 1778
gtc aag gct tat aat gag aaa gga aaa agc gat cca aga gtg ttg ggt 53541
Val Lys Ala Tyr Asn Glu Lys Gly Lys Ser Asp Pro Arg Val Leu Gly
1779 1779 1780
gtt cct gtc ata gcc aag gac ttg act ata cag cct agt tta aag tta 53589
Val Pro Val Ile Ala Lys Asp Leu Thr Ile Gln Pro Ser Leu Lys Leu
1780 1781 1781
cca ttt aac aca tat agt atc caa gct gga gaa gat ctt aaa ata gaa 53637
Pro Phe Asn Thr Tyr Ser Ile Gln Ala Gly Glu Asp Leu Lys Ile Glu
1782 1782 1783 1783
att cca gtt ata ggc cga cca aga cct aac att tct tgg gtc aaa gat 53685
Ile Pro Val Ile Gly Arg Pro Arg Pro Asn Ile Ser Trp Val Lys Asp
1784 1784 1785
ggt gag cct ctt aaa cag aca aca aga gta aac gtt gaa gaa aca gct 53733
Gly Glu Pro Leu Lys Gln Thr Thr Arg Val Asn Val Glu Glu Thr Ala
1785 1786 1786
acc tca act gtt ttg cac att aaa gaa ggt aac aaa gat gac ttt gga 53781
Thr Ser Thr Val Leu His Ile Lys Glu Gly Asn Lys Asp Asp Phe Gly
1787 1787 1788
aaa tac acc gta acg gca aca aat agt gca ggc aca gca aca gaa aat 53829
Lys Tyr Thr Val Thr Ala Thr Asn Ser Ala Gly Thr Ala Thr Glu Asn
1788 1789 1789
ctc agt gtt atc gtt tta gaa aag cct gga cct cca gtt ggc cca gtt 53877
Leu Ser Val Ile Val Leu Glu Lys Pro Gly Pro Pro Val Gly Pro Val
1790 1790 1791 1791
cgg ttt gat gaa gtt agt gca gac ttt gta gtc ata tct tgg gaa cct 53925
Arg Phe Asp Glu Val Ser Ala Asp Phe Val Val Ile Ser Trp Glu Pro
1792 1792 1793
cca gcc tat act ggt ggc tgc caa ata agc aac tac att gta gag aag 53973
Pro Ala Tyr Thr Gly Gly Cys Gln Ile Ser Asn Tyr Ile Val Glu Lys
1793 1794 1794
cga gat aca acc acc acc act tgg cac atg gta tca gca aca gtt gca 54021
Arg Asp Thr Thr Thr Thr Thr Trp His Met Val Ser Ala Thr Val Ala
1795 1795 1796
aga aca aca att aaa ata acc aaa ctg aaa aca ggc acg gag tac cag 54069
Arg Thr Thr Ile Lys Ile Thr Lys Leu Lys Thr Gly Thr Glu Tyr Gln
1796 1797 1797
ttt aga att ttt gct gaa aac agg tat gga aaa agt gcc cca ctg gat 54117
Phe Arg Ile Phe Ala Glu Asn Arg Tyr Gly Lys Ser Ala Pro Leu Asp
1798 1798 1799 1799
tct aag gca gtt att gta caa tat cca ttt aaa gaa cct gga cca cct 54165
Ser Lys Ala Val Ile Val Gln Tyr Pro Phe Lys Glu Pro Gly Pro Pro
1800 1800 1801
gga act cct ttt gtg aca tca atc tca aaa gat cag atg ctt gtg caa 54213
Gly Thr Pro Phe Val Thr Ser Ile Ser Lys Asp Gln Met Leu Val Gln
1801 1802 1802
tgg cat gag cca gtg aat gat gga ggc acc aaa att att ggc tac cat 54261
Trp His Glu Pro Val Asn Asp Gly Gly Thr Lys Ile Ile Gly Tyr His
1803 1803 1804
ctt gaa cag aaa gaa aag aac agt att tta tgg gtc aag tta aat aag 54309
Leu Glu Gln Lys Glu Lys Asn Ser Ile Leu Trp Val Lys Leu Asn Lys
1804 1805 1805
acc ccc att cag gac acc aaa ttc aaa aca act ggg ctt gat gag ggc 54357
Thr Pro Ile Gln Asp Thr Lys Phe Lys Thr Thr Gly Leu Asp Glu Gly
1806 1806 1807 1807
ctt gag tat gag ttc aaa gtt tct gct gaa aat att gtt ggc att ggc 54405
Leu Glu Tyr Glu Phe Lys Val Ser Ala Glu Asn Ile Val Gly Ile Gly
1808 1808 1809
aag cct agc aaa gtg tca gaa tgc ttt gtt gct cgt gat cca tgt gac 54453
Lys Pro Ser Lys Val Ser Glu Cys Phe Val Ala Arg Asp Pro Cys Asp
1809 1810 1810
cca cct ggt cgc cct gaa gcc att gtt att aca aga aac aat gtc aca 54501
Pro Pro Gly Arg Pro Glu Ala Ile Val Ile Thr Arg Asn Asn Val Thr
1811 1811 1812
ctg aaa tgg aag aaa cct gcc tat gat ggt ggt agc aaa ata aca ggt 54549
Leu Lys Trp Lys Lys Pro Ala Tyr Asp Gly Gly Ser Lys Ile Thr Gly
1812 1813 1813
tat att gta gaa aag aaa gat cta cct gat ggc cgc tgg atg aaa gcc 54597
Tyr Ile Val Glu Lys Lys Asp Leu Pro Asp Gly Arg Trp Met Lys Ala
1814 1814 1815 1815
agc ttt acc aac gta tta gaa act gaa ttt aca gtg agt gga ctt gta 54645
Ser Phe Thr Asn Val Leu Glu Thr Glu Phe Thr Val Ser Gly Leu Val
1816 1816 1817
gaa gac caa aga tat gaa ttt aga gta att gca aga aat gca gct gga 54693
Glu Asp Gln Arg Tyr Glu Phe Arg Val Ile Ala Arg Asn Ala Ala Gly
1817 1818 1818
aac ttt agt gaa cca tct gat agt agt ggt gcc att act gca aga gat 54741
Asn Phe Ser Glu Pro Ser Asp Ser Ser Gly Ala Ile Thr Ala Arg Asp
1819 1819 1820
gaa att gat gca cca aat gcc tct ctg gat cca aaa tat aaa gat gtc 54789
Glu Ile Asp Ala Pro Asn Ala Ser Leu Asp Pro Lys Tyr Lys Asp Val
1820 1821 1821
atc gtt gtt cat gca gga gag act ttt gtt ctt gaa gcc gac atc cgt 54837
Ile Val Val His Ala Gly Glu Thr Phe Val Leu Glu Ala Asp Ile Arg
1822 1822 1823 1823
ggc aaa cct ata cct gat gtt gtt tgg tca aaa gat gga aaa gaa ctt 54885
Gly Lys Pro Ile Pro Asp Val Val Trp Ser Lys Asp Gly Lys Glu Leu
1824 1824 1825
gaa gaa aca gct gct aga atg gaa att aaa tct act att cag aaa aca 54933
Glu Glu Thr Ala Ala Arg Met Glu Ile Lys Ser Thr Ile Gln Lys Thr
1825 1826 1826
act ctt gtt gtc aaa gac tgt ata cgg act gat gga gga caa tat att 54981
Thr Leu Val Val Lys Asp Cys Ile Arg Thr Asp Gly Gly Gln Tyr Ile
1827 1827 1828
ctg aaa ctc agc aat gtt ggt ggt aca aag tct ata ccc atc act gta 55029
Leu Lys Leu Ser Asn Val Gly Gly Thr Lys Ser Ile Pro Ile Thr Val
1828 1829 1829
aag gta ctt gac agg cca ggg tct cct gaa ggg cct ctg aaa gtt act 55077
Lys Val Leu Asp Arg Pro Gly Ser Pro Glu Gly Pro Leu Lys Val Thr
1830 1830 1831 1831
gga gtt act gcg gaa aaa tgt tac ctg gca tgg aac cca cct ttg caa 55125
Gly Val Thr Ala Glu Lys Cys Tyr Leu Ala Trp Asn Pro Pro Leu Gln
1832 1832 1833
gat ggt ggt gct aat att tca cat tac atc att gaa aag agg gag aca 55173
Asp Gly Gly Ala Asn Ile Ser His Tyr Ile Ile Glu Lys Arg Glu Thr
1833 1834 1834
agc cga ctc tct tgg acc cag gtt tca act gag gta cag gcc ctt aac 55221
Ser Arg Leu Ser Trp Thr Gln Val Ser Thr Glu Val Gln Ala Leu Asn
1835 1835 1836
tac aaa gtt act aaa ctt ctt cct ggt aat gag tac att ttc cgt gtc 55269
Tyr Lys Val Thr Lys Leu Leu Pro Gly Asn Glu Tyr Ile Phe Arg Val
1836 1837 1837
atg gct gtg aat aaa tat gga att gga gag ccc ttg gaa tct ggg cct 55317
Met Ala Val Asn Lys Tyr Gly Ile Gly Glu Pro Leu Glu Ser Gly Pro
1838 1838 1839 1839
gtt acg gcc tgt aat cct tat aag cca cca ggt cct ccc tca aca cct 55365
Val Thr Ala Cys Asn Pro Tyr Lys Pro Pro Gly Pro Pro Ser Thr Pro
1840 1840 1841
gaa gtc tca gca atc acc aaa gat tct atg gta gta aca tgg gca cgc 55413
Glu Val Ser Ala Ile Thr Lys Asp Ser Met Val Val Thr Trp Ala Arg
1841 1842 1842
cca gta gac gac gga ggt acc gaa att gag ggc tac att ctt gaa aaa 55461
Pro Val Asp Asp Gly Gly Thr Glu Ile Glu Gly Tyr Ile Leu Glu Lys
1843 1843 1844
cga gat aag gaa ggc gtt aga tgg acc aag tgc aac aag aaa aca tta 55509
Arg Asp Lys Glu Gly Val Arg Trp Thr Lys Cys Asn Lys Lys Thr Leu
1844 1845 1845
acg gat ctg cgg ctc agg gta act ggt ctt acc gaa ggc cat tcc tat 55557
Thr Asp Leu Arg Leu Arg Val Thr Gly Leu Thr Glu Gly His Ser Tyr
1846 1846 1847 1847
gaa ttc aga gtt gct gct gaa aat gca gct ggt gtg gga gaa cct agt 55605
Glu Phe Arg Val Ala Ala Glu Asn Ala Ala Gly Val Gly Glu Pro Ser
1848 1848 1849
gag cca tct gtt ttc tac cgt gcg tgt gat gcc ttg tat cca cca ggt 55653
Glu Pro Ser Val Phe Tyr Arg Ala Cys Asp Ala Leu Tyr Pro Pro Gly
1849 1850 1850
ccc cca agc aat cca aaa gtg acg gac act tcc aga tct tct gtc tcc 55701
Pro Pro Ser Asn Pro Lys Val Thr Asp Thr Ser Arg Ser Ser Val Ser
1851 1851 1852
ctg gca tgg agt aag cca att tat gat ggt ggc gca cct gtt aaa ggc 55749
Leu Ala Trp Ser Lys Pro Ile Tyr Asp Gly Gly Ala Pro Val Lys Gly
1852 1853 1853
tat gtt gta gag gtc aaa gaa gct gct gcg gat gaa tgg aca acc tgc 55797
Tyr Val Val Glu Val Lys Glu Ala Ala Ala Asp Glu Trp Thr Thr Cys
1854 1854 1855 1855
act cca cca aca gga tta caa gga aag cag ttc aca gtg acc aag ctt 55845
Thr Pro Pro Thr Gly Leu Gln Gly Lys Gln Phe Thr Val Thr Lys Leu
1856 1856 1857
aaa gaa aac act gaa tat aac ttc cgt att tgt gcc atc aat tct gaa 55893
Lys Glu Asn Thr Glu Tyr Asn Phe Arg Ile Cys Ala Ile Asn Ser Glu
1857 1858 1858
ggt gta ggt gaa cct gca act cta cct ggc tca gtg gtt gct cag gag 55941
Gly Val Gly Glu Pro Ala Thr Leu Pro Gly Ser Val Val Ala Gln Glu
1859 1859 1860
agg ata gag cca cca gaa ata gaa ctc gat gct gat ctc aga aag gtg 55989
Arg Ile Glu Pro Pro Glu Ile Glu Leu Asp Ala Asp Leu Arg Lys Val
1860 1861 1861
gtc gtt ctg cgt gca agt gct act tta cgc tta ttt gtc act atc aaa 56037
Val Val Leu Arg Ala Ser Ala Thr Leu Arg Leu Phe Val Thr Ile Lys
1862 1862 1863 1863
ggt cga cca gaa ccc gaa gtt aaa tgg gaa aag gca gaa ggc att ctc 56085
Gly Arg Pro Glu Pro Glu Val Lys Trp Glu Lys Ala Glu Gly Ile Leu
1864 1864 1865
act gac agg gct cag ata gag gtg acc agc tca ttt aca atg ttg gtg 56133
Thr Asp Arg Ala Gln Ile Glu Val Thr Ser Ser Phe Thr Met Leu Val
1865 1866 1866
att gat aat gtt acc aga ttt gac agt ggt cgg tat aat ctg aca tta 56181
Ile Asp Asn Val Thr Arg Phe Asp Ser Gly Arg Tyr Asn Leu Thr Leu
1867 1867 1868
gaa aat aat agt ggc tcc aaa aca gct ttt gtt aac gtc aga gtt ctt 56229
Glu Asn Asn Ser Gly Ser Lys Thr Ala Phe Val Asn Val Arg Val Leu
1868 1869 1869
gac tca cca agt gcc cct gtg aat ttg acc ata aga gaa gtg aag aaa 56277
Asp Ser Pro Ser Ala Pro Val Asn Leu Thr Ile Arg Glu Val Lys Lys
1870 1870 1871 1871
gac tca gtg acg ttg tcc tgg gaa cca cca ctt att gat ggt gga gct 56325
Asp Ser Val Thr Leu Ser Trp Glu Pro Pro Leu Ile Asp Gly Gly Ala
1872 1872 1873
aag att aca aac tac att gtc gaa aaa cga gaa act aca aga aaa gcc 56373
Lys Ile Thr Asn Tyr Ile Val Glu Lys Arg Glu Thr Thr Arg Lys Ala
1873 1874 1874
tat gct acc att aca aat aat tgc act aaa act act ttc aga att gaa 56421
Tyr Ala Thr Ile Thr Asn Asn Cys Thr Lys Thr Thr Phe Arg Ile Glu
1875 1875 1876
aat cta caa gaa gga tgt tct tac tac ttc cga gtc ttg gct tcc aat 56469
Asn Leu Gln Glu Gly Cys Ser Tyr Tyr Phe Arg Val Leu Ala Ser Asn
1876 1877 1877
gaa tat ggg att ggt ttg cca gct gaa aca aca gaa ccc gtt aaa gtg 56517
Glu Tyr Gly Ile Gly Leu Pro Ala Glu Thr Thr Glu Pro Val Lys Val
1878 1878 1879 1879
tct gaa cca ccc ctc cca cct gga aga gta act ctt gtt gat gtg acc 56565
Ser Glu Pro Pro Leu Pro Pro Gly Arg Val Thr Leu Val Asp Val Thr
1880 1880 1881
cgt aat aca gct aca att aag tgg gag aaa cca gaa agt gat ggt ggc 56613
Arg Asn Thr Ala Thr Ile Lys Trp Glu Lys Pro Glu Ser Asp Gly Gly
1881 1882 1882
agc aaa att act ggt tat gtg gtt gaa atg cag act aaa ggg agt gaa 56661
Ser Lys Ile Thr Gly Tyr Val Val Glu Met Gln Thr Lys Gly Ser Glu
1883 1883 1884
aag tgg agc acc tgc aca caa gtt aag act cta gaa gca act ata tct 56709
Lys Trp Ser Thr Cys Thr Gln Val Lys Thr Leu Glu Ala Thr Ile Ser
1884 1885 1885
ggc tta act gca gga gaa gag tat gtc ttc agg gta gct gca gtt aac 56757
Gly Leu Thr Ala Gly Glu Glu Tyr Val Phe Arg Val Ala Ala Val Asn
1886 1886 1887 1887
gaa aag gga aga agt gat cca aga caa ctt gga gtg cca gta att gca 56805
Glu Lys Gly Arg Ser Asp Pro Arg Gln Leu Gly Val Pro Val Ile Ala
1888 1888 1889
agg gat att gaa ata aag cct tca gtt gag ctt cct ttc cat act ttc 56853
Arg Asp Ile Glu Ile Lys Pro Ser Val Glu Leu Pro Phe His Thr Phe
1889 1890 1890
aat gta aag gct aga gaa caa ctt aag att gat gtg cca ttc aaa gga 56901
Asn Val Lys Ala Arg Glu Gln Leu Lys Ile Asp Val Pro Phe Lys Gly
1891 1891 1892
aga cct caa gct act gtg aac tgg aga aaa gat ggt cag act ctt aaa 56949
Arg Pro Gln Ala Thr Val Asn Trp Arg Lys Asp Gly Gln Thr Leu Lys
1892 1893 1893
gag aca act aga gtc aat gtt tct tct tca aag act gta aca tca cta 56997
Glu Thr Thr Arg Val Asn Val Ser Ser Ser Lys Thr Val Thr Ser Leu
1894 1894 1895 1895
tct att aag gaa gct tca aag gaa gat gtt gga act tat gaa tta tgt 57045
Ser Ile Lys Glu Ala Ser Lys Glu Asp Val Gly Thr Tyr Glu Leu Cys
1896 1896 1897
gtt tca aac agt gct gga tcc ata aca gtt cct att act ata att gtc 57093
Val Ser Asn Ser Ala Gly Ser Ile Thr Val Pro Ile Thr Ile Ile Val
1897 1898 1898
ctt gac aga cca gga cct cca ggt cct ata cgt att gat gag gtt agt 57141
Leu Asp Arg Pro Gly Pro Pro Gly Pro Ile Arg Ile Asp Glu Val Ser
1899 1899 1900
tgt gac agc ata acc att tct tgg aat cct cca gaa tat gat ggt ggc 57189
Cys Asp Ser Ile Thr Ile Ser Trp Asn Pro Pro Glu Tyr Asp Gly Gly
1900 1901 1901
tgc caa att agc aat tac att gtt gaa aag aaa gaa acc acc tct aca 57237
Cys Gln Ile Ser Asn Tyr Ile Val Glu Lys Lys Glu Thr Thr Ser Thr
1902 1902 1903 1903
aca tgg cac ata gtt tca caa gca gtt gca aga aca tcc att aaa ata 57285
Thr Trp His Ile Val Ser Gln Ala Val Ala Arg Thr Ser Ile Lys Ile
1904 1904 1905
gtt cgc ctg aca aca gga agt gag tat cag ttc cgt gtt tgt gca gaa 57333
Val Arg Leu Thr Thr Gly Ser Glu Tyr Gln Phe Arg Val Cys Ala Glu
1905 1906 1906
aac cgc tat gga aag agc tcc tac agt gaa tct tca gct gtt gtt gca 57381
Asn Arg Tyr Gly Lys Ser Ser Tyr Ser Glu Ser Ser Ala Val Val Ala
1907 1907 1908
gag tat cca ttc agt ccc cca ggt cct cct ggt act cct aaa gtt gtg 57429
Glu Tyr Pro Phe Ser Pro Pro Gly Pro Pro Gly Thr Pro Lys Val Val
1908 1909 1909
cat gcc aca aaa tct acc atg ctt gta acc tgg caa gtg cca gtt aat 57477
His Ala Thr Lys Ser Thr Met Leu Val Thr Trp Gln Val Pro Val Asn
1910 1910 1911 1911
gat gga gga agt cga gta att ggc tat cat ctt gag tat aaa gaa aga 57525
Asp Gly Gly Ser Arg Val Ile Gly Tyr His Leu Glu Tyr Lys Glu Arg
1912 1912 1913
agc agc att ctt tgg tca aaa gca aat aaa atc ctc att gct gat act 57573
Ser Ser Ile Leu Trp Ser Lys Ala Asn Lys Ile Leu Ile Ala Asp Thr
1913 1914 1914
caa gtg aaa gtc tcc ggc ctt gat gaa gga ctg atg tat gag tat cgt 57621
Gln Val Lys Val Ser Gly Leu Asp Glu Gly Leu Met Tyr Glu Tyr Arg
1915 1915 1916
gta tat gct gaa aat att gct gga att ggt aaa tgc agt aaa tct tgt 57669
Val Tyr Ala Glu Asn Ile Ala Gly Ile Gly Lys Cys Ser Lys Ser Cys
1916 1917 1917
gaa cca gtc cct gca aga gat cct tgt gac cct cct gga caa cct gaa 57717
Glu Pro Val Pro Ala Arg Asp Pro Cys Asp Pro Pro Gly Gln Pro Glu
1918 1918 1919 1919
gtc aca aat atc aca aga aaa tca gtg tca ctt aaa tgg tct aaa cca 57765
Val Thr Asn Ile Thr Arg Lys Ser Val Ser Leu Lys Trp Ser Lys Pro
1920 1920 1921
cat tat gat ggt gga gct aag atc aca gga tac att gtt gaa cgc aga 57813
His Tyr Asp Gly Gly Ala Lys Ile Thr Gly Tyr Ile Val Glu Arg Arg
1921 1922 1922
gaa cta cca gat ggc cgg tgg cta aag tgc aat tat act aat ata caa 57861
Glu Leu Pro Asp Gly Arg Trp Leu Lys Cys Asn Tyr Thr Asn Ile Gln
1923 1923 1924
gaa aca tac ttt gaa gta act gaa ctt act gaa gat cag cgt tat gaa 57909
Glu Thr Tyr Phe Glu Val Thr Glu Leu Thr Glu Asp Gln Arg Tyr Glu
1924 1925 1925
ttc cgg gtt ttt gca agg aat gct gct gac tca gtt agt gag cca tct 57957
Phe Arg Val Phe Ala Arg Asn Ala Ala Asp Ser Val Ser Glu Pro Ser
1926 1926 1927 1927
gaa tcc act ggg cct att ata gtt aaa gat gat gtt gag cct cca aga 58005
Glu Ser Thr Gly Pro Ile Ile Val Lys Asp Asp Val Glu Pro Pro Arg
1928 1928 1929
gtt atg atg gat gtc aag ttc cga gac gtt att gtt gtc aaa gct gga 58053
Val Met Met Asp Val Lys Phe Arg Asp Val Ile Val Val Lys Ala Gly
1929 1930 1930
gag gtc ctt aag ata aat gca gac att gca ggg cga cct ctg cca gta 58101
Glu Val Leu Lys Ile Asn Ala Asp Ile Ala Gly Arg Pro Leu Pro Val
1931 1931 1932
att tcc tgg gcc aag gat ggt ata gaa att gaa gaa aga gca aga aca 58149
Ile Ser Trp Ala Lys Asp Gly Ile Glu Ile Glu Glu Arg Ala Arg Thr
1932 1933 1933
gaa atc atc tca aca gac aat cat act ttg tta aca gtt aaa gac tgt 58197
Glu Ile Ile Ser Thr Asp Asn His Thr Leu Leu Thr Val Lys Asp Cys
1934 1934 1935 1935
ata aga cga gac act ggg caa tat gta cta aca ctg aag aat gtt gcc 58245
Ile Arg Arg Asp Thr Gly Gln Tyr Val Leu Thr Leu Lys Asn Val Ala
1936 1936 1937
ggc act cgg tct gtg gcc gtt aat tgc aaa gta ctt gat aag cct ggt 58293
Gly Thr Arg Ser Val Ala Val Asn Cys Lys Val Leu Asp Lys Pro Gly
1937 1938 1938
cca cca gca gga cca ctt gaa ata aat ggc ctc act gct gag aaa tgc 58341
Pro Pro Ala Gly Pro Leu Glu Ile Asn Gly Leu Thr Ala Glu Lys Cys
1939 1939 1940
tct ctt tcc tgg gga cgt ccc caa gaa gat ggt ggt gca gat atc gac 58389
Ser Leu Ser Trp Gly Arg Pro Gln Glu Asp Gly Gly Ala Asp Ile Asp
1940 1941 1941
tat tac cat cgt aaa aaa cgt gaa aca agc cac ctt gca tgg aca ata 58437
Tyr Tyr His Arg Lys Lys Arg Glu Thr Ser His Leu Ala Trp Thr Ile
1942 1942 1943 1943
tgt gaa gga gag tta cag atg aca tcc tgt aaa gta acc aag tta ctc 58485
Cys Glu Gly Glu Leu Gln Met Thr Ser Cys Lys Val Thr Lys Leu Leu
1944 1944 1945
aaa ggc aat gaa tat ata ttt aga gta act ggt gtt aat aaa tat ggt 58533
Lys Gly Asn Glu Tyr Ile Phe Arg Val Thr Gly Val Asn Lys Tyr Gly
1945 1946 1946
gtt ggt gag ccc cta gag agt gta gct ata aag gca cta gat cca ttt 58581
Val Gly Glu Pro Leu Glu Ser Val Ala Ile Lys Ala Leu Asp Pro Phe
1947 1947 1948
aca gtt cca agt cca ccc acg tct ttg gaa att act tct gtg acc aaa 58629
Thr Val Pro Ser Pro Pro Thr Ser Leu Glu Ile Thr Ser Val Thr Lys
1948 1949 1949
gaa tct atg aca ctt tgc tgg tca aga ccc gag agt gat gga ggt agt 58677
Glu Ser Met Thr Leu Cys Trp Ser Arg Pro Glu Ser Asp Gly Gly Ser
1950 1950 1951 1951
gaa ata tct gga tat ata att gaa agg cga gag aaa aat agc cta aga 58725
Glu Ile Ser Gly Tyr Ile Ile Glu Arg Arg Glu Lys Asn Ser Leu Arg
1952 1952 1953
tgg gtg cgt gta aac aaa aaa cca gtt tat gat cta aga gtg aaa tca 58773
Trp Val Arg Val Asn Lys Lys Pro Val Tyr Asp Leu Arg Val Lys Ser
1953 1954 1954
aca gga ctt cgg gaa gga tgt gaa tat gaa tat cgt gtt tat gca gaa 58821
Thr Gly Leu Arg Glu Gly Cys Glu Tyr Glu Tyr Arg Val Tyr Ala Glu
1955 1955 1956
aat gct gct ggc cta agt ctt cca agt gaa acc tct ccc tta att agg 58869
Asn Ala Ala Gly Leu Ser Leu Pro Ser Glu Thr Ser Pro Leu Ile Arg
1956 1957 1957
gca gaa gat cca gtg ttc cta cca tct cct cca tcc aaa ccc aaa att 58917
Ala Glu Asp Pro Val Phe Leu Pro Ser Pro Pro Ser Lys Pro Lys Ile
1958 1958 1959 1959
gtg gac tca ggc aag aca act ata act att gcc tgg gtt aag ccg ctg 58965
Val Asp Ser Gly Lys Thr Thr Ile Thr Ile Ala Trp Val Lys Pro Leu
1960 1960 1961
ttt gat ggt ggg gcc ccg ata act gga tat act gta gaa tac aaa aaa 59013
Phe Asp Gly Gly Ala Pro Ile Thr Gly Tyr Thr Val Glu Tyr Lys Lys
1961 1962 1962
tct gat gac act gac tgg aaa act tcc att cag agc tta cga ggg aca 59061
Ser Asp Asp Thr Asp Trp Lys Thr Ser Ile Gln Ser Leu Arg Gly Thr
1963 1963 1964
gaa tat aca ata agc gga cta aca aca gga gct gaa tat gtt ttc aga 59109
Glu Tyr Thr Ile Ser Gly Leu Thr Thr Gly Ala Glu Tyr Val Phe Arg
1964 1965 1965
gta aaa tct gtc aat aag gtt ggt gct agt gac ccc agt gat agc tct 59157
Val Lys Ser Val Asn Lys Val Gly Ala Ser Asp Pro Ser Asp Ser Ser
1966 1966 1967 1967
gac cct cag ata gca aag gaa aga gaa gaa gaa cct tta ttt gat att 59205
Asp Pro Gln Ile Ala Lys Glu Arg Glu Glu Glu Pro Leu Phe Asp Ile
1968 1968 1969
gac agt gaa atg agg aag acc ttg att gtc aag gct ggt gcc tca ttt 59253
Asp Ser Glu Met Arg Lys Thr Leu Ile Val Lys Ala Gly Ala Ser Phe
1969 1970 1970
acc atg act gtg cct ttc cga gga aga cca gta ccc aat gtc ttg tgg 59301
Thr Met Thr Val Pro Phe Arg Gly Arg Pro Val Pro Asn Val Leu Trp
1971 1971 1972
agt aag cca gac act gac ctc cgt act aga gct tat gtt gat acc aca 59349
Ser Lys Pro Asp Thr Asp Leu Arg Thr Arg Ala Tyr Val Asp Thr Thr
1972 1973 1973
gac tct cgt aca tca ctg acc att gaa aat gcc aac aga aat gac tct 59397
Asp Ser Arg Thr Ser Leu Thr Ile Glu Asn Ala Asn Arg Asn Asp Ser
1974 1974 1975 1975
gga aag tac aca tta aca att cag aat gtt ttg agt gct gct tca ctg 59445
Gly Lys Tyr Thr Leu Thr Ile Gln Asn Val Leu Ser Ala Ala Ser Leu
1976 1976 1977
acc tta gtt gtc aaa gtt tta gat acc cca ggt cct cca acc aac att 59493
Thr Leu Val Val Lys Val Leu Asp Thr Pro Gly Pro Pro Thr Asn Ile
1977 1978 1978
act gtg caa gat gta acc aaa gag tct gca gtg tta tcc tgg gat gtt 59541
Thr Val Gln Asp Val Thr Lys Glu Ser Ala Val Leu Ser Trp Asp Val
1979 1979 1980
cct gaa aac gat ggt gga gca cca gtg aag aat tac cac ata gaa aaa 59589
Pro Glu Asn Asp Gly Gly Ala Pro Val Lys Asn Tyr His Ile Glu Lys
1980 1981 1981
cgt gag gcc agc aag aaa gca tgg gtc tct gtg acc aac aac tgt aac 59637
Arg Glu Ala Ser Lys Lys Ala Trp Val Ser Val Thr Asn Asn Cys Asn
1982 1982 1983 1983
cgc ctc tcc tac aaa gtt acc aat tta caa gaa gga gct atc tat tac 59685
Arg Leu Ser Tyr Lys Val Thr Asn Leu Gln Glu Gly Ala Ile Tyr Tyr
1984 1984 1985
ttc aga gtc tct gga gaa aat gag ttt ggt gtt ggt ata cca gct gaa 59733
Phe Arg Val Ser Gly Glu Asn Glu Phe Gly Val Gly Ile Pro Ala Glu
1985 1986 1986
aca aag gaa gga gta aaa ata aca gaa aaa cca agc cca cct gaa aaa 59781
Thr Lys Glu Gly Val Lys Ile Thr Glu Lys Pro Ser Pro Pro Glu Lys
1987 1987 1988
ctt gga gta aca agt ata tcc aaa gac agt gtt tcc ctg acc tgg ctg 59829
Leu Gly Val Thr Ser Ile Ser Lys Asp Ser Val Ser Leu Thr Trp Leu
1988 1989 1989
aag cct gaa cat gat ggc gga agc aga att gta cac tat gtc gtt gaa 59877
Lys Pro Glu His Asp Gly Gly Ser Arg Ile Val His Tyr Val Val Glu
1990 1990 1991 1991
gca cta gaa aaa gga cag aaa aac tgg gtt aaa tgt gca gtg gca aag 59925
Ala Leu Glu Lys Gly Gln Lys Asn Trp Val Lys Cys Ala Val Ala Lys
1992 1992 1993
tca acc cat cac gtt gtt tcc ggt ctg aga gag aat tct gaa tac ttt 59973
Ser Thr His His Val Val Ser Gly Leu Arg Glu Asn Ser Glu Tyr Phe
1993 1994 1994
ttc cga gtg ttt gct gaa aat caa gct ggc ctg agt gac ccg aga gag 60021
Phe Arg Val Phe Ala Glu Asn Gln Ala Gly Leu Ser Asp Pro Arg Glu
1995 1995 1996
ctt ctg ctt cct gtt ctt att aag gag caa cta gaa cca cct gaa att 60069
Leu Leu Leu Pro Val Leu Ile Lys Glu Gln Leu Glu Pro Pro Glu Ile
1996 1997 1997
gat atg aag aat ttc cca agt cac act gta tat gtt aga gct ggt tca 60117
Asp Met Lys Asn Phe Pro Ser His Thr Val Tyr Val Arg Ala Gly Ser
1998 1998 1999 1999
aac ctt aaa gtt gac att cca atc tct gga aaa cca ctt ccc aaa gtg 60165
Asn Leu Lys Val Asp Ile Pro Ile Ser Gly Lys Pro Leu Pro Lys Val
2000 2000 2001
acc tta tca aga gat ggt gtc ccc ctt aag gca acc atg aga ttt aat 60213
Thr Leu Ser Arg Asp Gly Val Pro Leu Lys Ala Thr Met Arg Phe Asn
2001 2002 2002
acc gaa att act gct gag aac ctg acc atc aat ctc aaa gaa agt gtt 60261
Thr Glu Ile Thr Ala Glu Asn Leu Thr Ile Asn Leu Lys Glu Ser Val
2003 2003 2004
aca gct gac gct ggg aga tat gaa atc act gct gcc aac tcc agt ggt 60309
Thr Ala Asp Ala Gly Arg Tyr Glu Ile Thr Ala Ala Asn Ser Ser Gly
2004 2005 2005
aca acc aaa gct ttc att aac att gtt gtg cta gac agg cct ggt cct 60357
Thr Thr Lys Ala Phe Ile Asn Ile Val Val Leu Asp Arg Pro Gly Pro
2006 2006 2007 2007
cca act ggc cct gtt gtt att agt gat ata act gaa gaa agt gtg act 60405
Pro Thr Gly Pro Val Val Ile Ser Asp Ile Thr Glu Glu Ser Val Thr
2008 2008 2009
ctc aaa tgg gag cca cct aag tat gac ggt gga agt caa gtt acc aac 60453
Leu Lys Trp Glu Pro Pro Lys Tyr Asp Gly Gly Ser Gln Val Thr Asn
2009 2010 2010
tac att cta ctc aaa aga gaa aca agt act gca gtg tgg act gaa gtg 60501
Tyr Ile Leu Leu Lys Arg Glu Thr Ser Thr Ala Val Trp Thr Glu Val
2011 2011 2012
tct gca aca gtt gca aga acc atg atg aaa gtc atg aaa ctg acc aca 60549
Ser Ala Thr Val Ala Arg Thr Met Met Lys Val Met Lys Leu Thr Thr
2012 2013 2013
gga gaa gaa tac caa ttc cgc atc aag gca gaa aac cgc ttt ggc atc 60597
Gly Glu Glu Tyr Gln Phe Arg Ile Lys Ala Glu Asn Arg Phe Gly Ile
2014 2014 2015 2015
agt gat cat ata gat tca gct tgt gtg act gtc aaa cta cca tac aca 60645
Ser Asp His Ile Asp Ser Ala Cys Val Thr Val Lys Leu Pro Tyr Thr
2016 2016 2017
aca cct gga cca cca tct aca cca tgg gtc act aat gtt act cga gaa 60693
Thr Pro Gly Pro Pro Ser Thr Pro Trp Val Thr Asn Val Thr Arg Glu
2017 2018 2018
agc atc act gtg ggc tgg cat gaa cca gtg tca aat gga ggc agt gca 60741
Ser Ile Thr Val Gly Trp His Glu Pro Val Ser Asn Gly Gly Ser Ala
2019 2019 2020
gtc gta ggc tat cac ctg gaa atg aaa gac aga aac agt att tta tgg 60789
Val Val Gly Tyr His Leu Glu Met Lys Asp Arg Asn Ser Ile Leu Trp
2020 2021 2021
caa aaa gcc aac aaa ctg gtc atc cgc aca act cac ttc aaa gtc aca 60837
Gln Lys Ala Asn Lys Leu Val Ile Arg Thr Thr His Phe Lys Val Thr
2022 2022 2023 2023
aca atc agt gct gga ctt att tat gaa ttc agg gtg tat gca gaa aat 60885
Thr Ile Ser Ala Gly Leu Ile Tyr Glu Phe Arg Val Tyr Ala Glu Asn
2024 2024 2025
gct gct gga gtt gga aaa cct agc cat cct tct gaa cca gtc ttg gca 60933
Ala Ala Gly Val Gly Lys Pro Ser His Pro Ser Glu Pro Val Leu Ala
2025 2026 2026
att gat gct tgt gaa ccc cca aga aat gtt cgt atc act gat att tca 60981
Ile Asp Ala Cys Glu Pro Pro Arg Asn Val Arg Ile Thr Asp Ile Ser
2027 2027 2028
aag aac tct gtc agc ctt tca tgg caa caa cca gct ttc gat gga ggt 61029
Lys Asn Ser Val Ser Leu Ser Trp Gln Gln Pro Ala Phe Asp Gly Gly
2028 2029 2029
agc aag att aca ggc tac att gtt gag aga cgt gac ctt cca gat ggc 61077
Ser Lys Ile Thr Gly Tyr Ile Val Glu Arg Arg Asp Leu Pro Asp Gly
2030 2030 2031 2031
aga tgg acc aag gcc agc ttc acc aat gtt act gaa act caa ttc acc 61125
Arg Trp Thr Lys Ala Ser Phe Thr Asn Val Thr Glu Thr Gln Phe Thr
2032 2032 2033
atc tct ggc ttg act cag aat tcc cag tat gaa ttc cgt gtc ttt gct 61173
Ile Ser Gly Leu Thr Gln Asn Ser Gln Tyr Glu Phe Arg Val Phe Ala
2033 2034 2034
agg aat gct gtt ggt tcc att agc aat cca tct gag gtt gta ggg ccc 61221
Arg Asn Ala Val Gly Ser Ile Ser Asn Pro Ser Glu Val Val Gly Pro
2035 2035 2036
att act tgc atc gat tct tat ggt ggt cct gta att gat ttg cct cta 61269
Ile Thr Cys Ile Asp Ser Tyr Gly Gly Pro Val Ile Asp Leu Pro Leu
2036 2037 2037
gaa tat aca gaa gtt gtc aaa tac aga gca ggt aca tct gtg aag ctc 61317
Glu Tyr Thr Glu Val Val Lys Tyr Arg Ala Gly Thr Ser Val Lys Leu
2038 2038 2039 2039
aga gct ggc att tct ggc aaa cct gcg cct act att gag tgg tat aaa 61365
Arg Ala Gly Ile Ser Gly Lys Pro Ala Pro Thr Ile Glu Trp Tyr Lys
2040 2040 2041
gat gat aaa gaa tta caa acc aat gca ctg gtg tgt gtt gaa aat acc 61413
Asp Asp Lys Glu Leu Gln Thr Asn Ala Leu Val Cys Val Glu Asn Thr
2041 2042 2042
acg gac ctc gca tct ata ctc atc aaa gat gcc gat cgc ctt aat agt 61461
Thr Asp Leu Ala Ser Ile Leu Ile Lys Asp Ala Asp Arg Leu Asn Ser
2043 2043 2044
gga tgc tat gaa tta aaa cta agg aat gcc atg gcg tca gcc tca gcc 61509
Gly Cys Tyr Glu Leu Lys Leu Arg Asn Ala Met Ala Ser Ala Ser Ala
2044 2045 2045
acc atc aga gta cag atc ctt gac aaa cca ggc cca cct ggt gga cca 61557
Thr Ile Arg Val Gln Ile Leu Asp Lys Pro Gly Pro Pro Gly Gly Pro
2046 2046 2047 2047
att gaa ttt aag act gta act gct gag aag atc acc ctt ctc tgg cgg 61605
Ile Glu Phe Lys Thr Val Thr Ala Glu Lys Ile Thr Leu Leu Trp Arg
2048 2048 2049
cct cca gct gat gat ggt ggt gca aaa atc act cac tac att gtg gaa 61653
Pro Pro Ala Asp Asp Gly Gly Ala Lys Ile Thr His Tyr Ile Val Glu
2049 2050 2050
aag cgt gag aca agc cgc gtt gtg tgg tct atg gtg tct gaa cat ttg 61701
Lys Arg Glu Thr Ser Arg Val Val Trp Ser Met Val Ser Glu His Leu
2051 2051 2052
gaa gag tgc atc att aca acc acc aaa att atc aaa gga aat gaa tac 61749
Glu Glu Cys Ile Ile Thr Thr Thr Lys Ile Ile Lys Gly Asn Glu Tyr
2052 2053 2053
atc ttc cgg gtc cga gcc gtg aac aaa tat gga att ggc gag cca ctg 61797
Ile Phe Arg Val Arg Ala Val Asn Lys Tyr Gly Ile Gly Glu Pro Leu
2054 2054 2055 2055
gaa tct gat tcc gtt gta gcc aag aac gca ttt gtt aca cct ggg cca 61845
Glu Ser Asp Ser Val Val Ala Lys Asn Ala Phe Val Thr Pro Gly Pro
2056 2056 2057
cca ggc ata cca gaa gtg aca aag att acc aag aat tcg atg act gtt 61893
Pro Gly Ile Pro Glu Val Thr Lys Ile Thr Lys Asn Ser Met Thr Val
2057 2058 2058
gta tgg agc agg cca att gca gat ggc ggt agt gat ata agt ggc tat 61941
Val Trp Ser Arg Pro Ile Ala Asp Gly Gly Ser Asp Ile Ser Gly Tyr
2059 2059 2060
ttc ctt gaa aaa cga gac aag aag agc cta gga tgg ttt aaa gta cta 61989
Phe Leu Glu Lys Arg Asp Lys Lys Ser Leu Gly Trp Phe Lys Val Leu
2060 2061 2061
aaa gag act atc cgt gac acc aga caa aaa gta aca gga ctc aca gaa 62037
Lys Glu Thr Ile Arg Asp Thr Arg Gln Lys Val Thr Gly Leu Thr Glu
2062 2062 2063 2063
aac agt gac tat caa tac aga gtt tgt gct gta aac gct gct gga cag 62085
Asn Ser Asp Tyr Gln Tyr Arg Val Cys Ala Val Asn Ala Ala Gly Gln
2064 2064 2065
ggt cca ttt tct gaa cca tct gaa ttc tac aaa gct gct gat cct att 62133
Gly Pro Phe Ser Glu Pro Ser Glu Phe Tyr Lys Ala Ala Asp Pro Ile
2065 2066 2066
gat cct cca ggt cca cct gct aag ata aga atc gca gat tca acc aag 62181
Asp Pro Pro Gly Pro Pro Ala Lys Ile Arg Ile Ala Asp Ser Thr Lys
2067 2067 2068
tca tcc atc acc ctt ggc tgg agt aag cct gtc tat gat ggg ggc agt 62229
Ser Ser Ile Thr Leu Gly Trp Ser Lys Pro Val Tyr Asp Gly Gly Ser
2068 2069 2069
gct gtt act ggg tat gtt gtc gag ata aga caa gga gag gaa gag gaa 62277
Ala Val Thr Gly Tyr Val Val Glu Ile Arg Gln Gly Glu Glu Glu Glu
2070 2070 2071 2071
tgg act act gtc tct acc aaa gga gag gtc aga act aca gaa tat gtg 62325
Trp Thr Thr Val Ser Thr Lys Gly Glu Val Arg Thr Thr Glu Tyr Val
2072 2072 2073
gta tcc aac ctg aaa cct gga gtc aat tac tac ttc cgg gta tct gct 62373
Val Ser Asn Leu Lys Pro Gly Val Asn Tyr Tyr Phe Arg Val Ser Ala
2073 2074 2074
gta aac tgt gct gga caa gga gaa cct ata gaa atg aat gaa cct gta 62421
Val Asn Cys Ala Gly Gln Gly Glu Pro Ile Glu Met Asn Glu Pro Val
2075 2075 2076
caa gct aaa gat ata ctt gag gca cca gag att gac ctg gat gtg gct 62469
Gln Ala Lys Asp Ile Leu Glu Ala Pro Glu Ile Asp Leu Asp Val Ala
2076 2077 2077
ctc aga act tct gtt att gcc aaa gct ggt gaa gat gta caa gtg ttg 62517
Leu Arg Thr Ser Val Ile Ala Lys Ala Gly Glu Asp Val Gln Val Leu
2078 2078 2079 2079
att ccc ttt aaa ggc aga cct cca cct act gtc aca tgg aga aaa gat 62565
Ile Pro Phe Lys Gly Arg Pro Pro Pro Thr Val Thr Trp Arg Lys Asp
2080 2080 2081
gag aag aat ctt ggc agt gat gcc aga tac agc att gaa aac act gat 62613
Glu Lys Asn Leu Gly Ser Asp Ala Arg Tyr Ser Ile Glu Asn Thr Asp
2081 2082 2082
tca tcc tca tta ctc acc att cct caa gtt act cgc aat gat aca gga 62661
Ser Ser Ser Leu Leu Thr Ile Pro Gln Val Thr Arg Asn Asp Thr Gly
2083 2083 2084
aaa tat att ctc aca ata gaa aat gga gtt ggt gaa cct aag tct tca 62709
Lys Tyr Ile Leu Thr Ile Glu Asn Gly Val Gly Glu Pro Lys Ser Ser
2084 2085 2085
act gtg agt gtt aaa gtg ctt gac aca cca gct gcc tgc cag aaa cta 62757
Thr Val Ser Val Lys Val Leu Asp Thr Pro Ala Ala Cys Gln Lys Leu
2086 2086 2087 2087
cag gtt aaa cat gtt tct cga ggc aca gtc act ttg ctc tgg gat cct 62805
Gln Val Lys His Val Ser Arg Gly Thr Val Thr Leu Leu Trp Asp Pro
2088 2088 2089
cct ctc att gat gga gga tct cca ata att aat tat gtc att gaa aag 62853
Pro Leu Ile Asp Gly Gly Ser Pro Ile Ile Asn Tyr Val Ile Glu Lys
2089 2090 2090
aga gat gcc acc aag aga aca tgg tct gtc gtg tca cac aaa tgt tct 62901
Arg Asp Ala Thr Lys Arg Thr Trp Ser Val Val Ser His Lys Cys Ser
2091 2091 2092
agc aca tcc ttc aag cta ata gat ttg tcg gag aag act cca ttc ttc 62949
Ser Thr Ser Phe Lys Leu Ile Asp Leu Ser Glu Lys Thr Pro Phe Phe
2092 2093 2093
ttc aga gtt ctt gca gaa aat gaa att gga att ggg gaa ccc tgt gaa 62997
Phe Arg Val Leu Ala Glu Asn Glu Ile Gly Ile Gly Glu Pro Cys Glu
2094 2094 2095 2095
act aca gag cca gtg aag gct gct gaa gta cca gct cct ata cgt gat 63045
Thr Thr Glu Pro Val Lys Ala Ala Glu Val Pro Ala Pro Ile Arg Asp
2096 2096 2097
ctc tca atg aaa gac tca aca aag aca tct gtc atc ctc agc tgg acc 63093
Leu Ser Met Lys Asp Ser Thr Lys Thr Ser Val Ile Leu Ser Trp Thr
2097 2098 2098
aaa cct gac ttt gat ggt ggt agc gtc atc aca gaa tat gtt gta gaa 63141
Lys Pro Asp Phe Asp Gly Gly Ser Val Ile Thr Glu Tyr Val Val Glu
2099 2099 2100
agg aaa ggt aaa ggt gaa cag acg tgg tcc cac gct ggc ata agt aag 63189
Arg Lys Gly Lys Gly Glu Gln Thr Trp Ser His Ala Gly Ile Ser Lys
2100 2101 2101
aca tgt gaa att gag gtt agc caa ctt aag gag cag tca gtc ctg gag 63237
Thr Cys Glu Ile Glu Val Ser Gln Leu Lys Glu Gln Ser Val Leu Glu
2102 2102 2103 2103
ttc aga gtg ttt gcc aaa aat gag aaa gga ctg agt gat cct gtc act 63285
Phe Arg Val Phe Ala Lys Asn Glu Lys Gly Leu Ser Asp Pro Val Thr
2104 2104 2105
att ggg cca att aca gtg aaa gaa ctt att att aca cct gaa gtt gac 63333
Ile Gly Pro Ile Thr Val Lys Glu Leu Ile Ile Thr Pro Glu Val Asp
2105 2106 2106
ctg tca gat atc cct ggg gca caa gtc act gtg aga att ggg cac aat 63381
Leu Ser Asp Ile Pro Gly Ala Gln Val Thr Val Arg Ile Gly His Asn
2107 2107 2108
gtg cac ctt gaa tta cct tat aag gga aaa ccc aaa cca tcc atc agt 63429
Val His Leu Glu Leu Pro Tyr Lys Gly Lys Pro Lys Pro Ser Ile Ser
2108 2109 2109
tgg ctg aaa gat ggc ttg cca ctg aaa gaa agt gaa ttt gtt cgc ttc 63477
Trp Leu Lys Asp Gly Leu Pro Leu Lys Glu Ser Glu Phe Val Arg Phe
2110 2110 2111 2111
agt aaa act gaa aac aaa att act ttg agt att aag aat gcc aag aag 63525
Ser Lys Thr Glu Asn Lys Ile Thr Leu Ser Ile Lys Asn Ala Lys Lys
2112 2112 2113
gag cat gga gga aaa tac act gtt att ctt gat aat gca gtg tgt aga 63573
Glu His Gly Gly Lys Tyr Thr Val Ile Leu Asp Asn Ala Val Cys Arg
2113 2114 2114
att gca gtc ccc att aca gtc atc acc ctt ggc cca cca tca aag ccc 63621
Ile Ala Val Pro Ile Thr Val Ile Thr Leu Gly Pro Pro Ser Lys Pro
2115 2115 2116
aaa gga ccc att cga ttt gat gaa atc aag gct gat agt gtc atc ctg 63669
Lys Gly Pro Ile Arg Phe Asp Glu Ile Lys Ala Asp Ser Val Ile Leu
2116 2117 2117
tca tgg gat gta cct gaa gat aat gga gga gga gaa att act tgt tac 63717
Ser Trp Asp Val Pro Glu Asp Asn Gly Gly Gly Glu Ile Thr Cys Tyr
2118 2118 2119 2119
agc atc gag aag cgg gaa act tca caa act aac tgg aag atg gtg tgt 63765
Ser Ile Glu Lys Arg Glu Thr Ser Gln Thr Asn Trp Lys Met Val Cys
2120 2120 2121
tca agt gtt gcc aga acg act ttc aaa gtt cct aat cta gtc aaa gat 63813
Ser Ser Val Ala Arg Thr Thr Phe Lys Val Pro Asn Leu Val Lys Asp
2121 2122 2122
gct gaa tac cag ttt aga gtg aga gca gaa aac aga tac gga gtc agc 63861
Ala Glu Tyr Gln Phe Arg Val Arg Ala Glu Asn Arg Tyr Gly Val Ser
2123 2123 2124
caa cca ctt gtc tca agc att att gtg gca aaa cac cag ttc agg att 63909
Gln Pro Leu Val Ser Ser Ile Ile Val Ala Lys His Gln Phe Arg Ile
2124 2125 2125
cct ggt ccc cca gga aag cca gtt ata tac aat gtg act tct gat ggc 63957
Pro Gly Pro Pro Gly Lys Pro Val Ile Tyr Asn Val Thr Ser Asp Gly
2126 2126 2127 2127
atg tca cta act tgg gat gct cca gtt tat gat ggt ggt tca gaa gtt 64005
Met Ser Leu Thr Trp Asp Ala Pro Val Tyr Asp Gly Gly Ser Glu Val
2128 2128 2129
act gga ttc cat gtt gaa aag aaa gaa aga aat agc atc ctc tgg caa 64053
Thr Gly Phe His Val Glu Lys Lys Glu Arg Asn Ser Ile Leu Trp Gln
2129 2130 2130
aaa gtt aat aca tca cca atc tct gga aga gaa tat aga gcc act gga 64101
Lys Val Asn Thr Ser Pro Ile Ser Gly Arg Glu Tyr Arg Ala Thr Gly
2131 2131 2132
ctg gta gaa ggt ctg gat tac caa ttc cgt gta tat gct gaa aat tct 64149
Leu Val Glu Gly Leu Asp Tyr Gln Phe Arg Val Tyr Ala Glu Asn Ser
2132 2133 2133
gct ggc cta agc tca cct agt gac cca agc aaa ttt acc tta gct gtt 64197
Ala Gly Leu Ser Ser Pro Ser Asp Pro Ser Lys Phe Thr Leu Ala Val
2134 2134 2135 2135
tct cca gta gac cca cct ggc act cct gac tac att gat gtc acc cgg 64245
Ser Pro Val Asp Pro Pro Gly Thr Pro Asp Tyr Ile Asp Val Thr Arg
2136 2136 2137
gaa acc atc aca ctt aaa tgg aac cca cca ttg cgt gat gga ggc agt 64293
Glu Thr Ile Thr Leu Lys Trp Asn Pro Pro Leu Arg Asp Gly Gly Ser
2137 2138 2138
aag att gtg ggc tat agc att gag aaa cgg caa gga aat gaa cgc tgg 64341
Lys Ile Val Gly Tyr Ser Ile Glu Lys Arg Gln Gly Asn Glu Arg Trp
2139 2139 2140
gtg aga tgc aac ttt act gac gtc agt gaa tgt cag tac aca gtt aca 64389
Val Arg Cys Asn Phe Thr Asp Val Ser Glu Cys Gln Tyr Thr Val Thr
2140 2141 2141
gga ctc agt cct ggg gat cgc tat gag ttc aga ata att gca aga aat 64437
Gly Leu Ser Pro Gly Asp Arg Tyr Glu Phe Arg Ile Ile Ala Arg Asn
2142 2142 2143 2143
gct gtt gga act ata agc ccg ccc tca cag tct tct ggc att att atg 64485
Ala Val Gly Thr Ile Ser Pro Pro Ser Gln Ser Ser Gly Ile Ile Met
2144 2144 2145
aca aga gat gaa aat gtt cca cca ata gta gag ttt ggc cct gaa tac 64533
Thr Arg Asp Glu Asn Val Pro Pro Ile Val Glu Phe Gly Pro Glu Tyr
2145 2146 2146
ttt gat ggt ctc att att aag tcc gga gag agc ctt aga att aaa gct 64581
Phe Asp Gly Leu Ile Ile Lys Ser Gly Glu Ser Leu Arg Ile Lys Ala
2147 2147 2148
ttg gta caa gga aga cca gtg cct cga gta act tgg ttc aaa gat gga 64629
Leu Val Gln Gly Arg Pro Val Pro Arg Val Thr Trp Phe Lys Asp Gly
2148 2149 2149
gtg gaa atc gaa aag agg atg aat atg gaa ata acc aac gta ctt gga 64677
Val Glu Ile Glu Lys Arg Met Asn Met Glu Ile Thr Asn Val Leu Gly
2150 2150 2151 2151
tcc acc agc cta ttt gtt aga gat gct act cgg gac cat cgt ggt gta 64725
Ser Thr Ser Leu Phe Val Arg Asp Ala Thr Arg Asp His Arg Gly Val
2152 2152 2153
tac aca gtg gaa gcc aaa aat gca tct ggt tct gca aaa gca gaa att 64773
Tyr Thr Val Glu Ala Lys Asn Ala Ser Gly Ser Ala Lys Ala Glu Ile
2153 2154 2154
aaa gtg aaa gta caa gat aca cca gga aaa gta gtt ggg cca ata aga 64821
Lys Val Lys Val Gln Asp Thr Pro Gly Lys Val Val Gly Pro Ile Arg
2155 2155 2156
ttc acc aat att act ggg gag aag atg act ctg tgg tgg gat gcc cca 64869
Phe Thr Asn Ile Thr Gly Glu Lys Met Thr Leu Trp Trp Asp Ala Pro
2156 2157 2157
ctc aat gac ggt tgt gct ccc ata acc cac tac atc att gaa aaa cgg 64917
Leu Asn Asp Gly Cys Ala Pro Ile Thr His Tyr Ile Ile Glu Lys Arg
2158 2158 2159 2159
gaa acc agc aga ctt gcc tgg gca cta att gag gat aaa tgt gaa gcc 64965
Glu Thr Ser Arg Leu Ala Trp Ala Leu Ile Glu Asp Lys Cys Glu Ala
2160 2160 2161
caa agt tac act gcc att aaa cta ata aac ggc aat gaa tac caa ttc 65013
Gln Ser Tyr Thr Ala Ile Lys Leu Ile Asn Gly Asn Glu Tyr Gln Phe
2161 2162 2162
cgt gtt tct gca gtt aac aag ttt ggt gtt ggc agg cca ctt gat tct 65061
Arg Val Ser Ala Val Asn Lys Phe Gly Val Gly Arg Pro Leu Asp Ser
2163 2163 2164
gat cca gtg gtt gct caa ata caa tat act gtt cct gat gcc cct ggc 65109
Asp Pro Val Val Ala Gln Ile Gln Tyr Thr Val Pro Asp Ala Pro Gly
2164 2165 2165
att cca gaa cct agc aac ata aca ggc aac agc att acc ctg aca tgg 65157
Ile Pro Glu Pro Ser Asn Ile Thr Gly Asn Ser Ile Thr Leu Thr Trp
2166 2166 2167 2167
gca agg cca gaa tca gat ggt ggc agt gaa att caa cag tat atc ctt 65205
Ala Arg Pro Glu Ser Asp Gly Gly Ser Glu Ile Gln Gln Tyr Ile Leu
2168 2168 2169
gaa aga aga gaa aag aaa agc aca aga tgg gta aaa gtg atc agc aaa 65253
Glu Arg Arg Glu Lys Lys Ser Thr Arg Trp Val Lys Val Ile Ser Lys
2169 2170 2170
cga cca atc tct gaa aca aga ttc aaa gtc act ggt ctg aca gaa ggc 65301
Arg Pro Ile Ser Glu Thr Arg Phe Lys Val Thr Gly Leu Thr Glu Gly
2171 2171 2172
aat gag tat gaa ttc cat gtc atg gct gaa aat gct gca gga gtt gga 65349
Asn Glu Tyr Glu Phe His Val Met Ala Glu Asn Ala Ala Gly Val Gly
2172 2173 2173
cct gca agt ggc atc tca aga ctc att aaa tgt aga gag ccc gtc aac 65397
Pro Ala Ser Gly Ile Ser Arg Leu Ile Lys Cys Arg Glu Pro Val Asn
2174 2174 2175 2175
cca cca ggt cct ccc aca gtg gtc aaa gta aca gac aca tca aag aca 65445
Pro Pro Gly Pro Pro Thr Val Val Lys Val Thr Asp Thr Ser Lys Thr
2176 2176 2177
act gtg agc tta gaa tgg tcc aaa cca gtg ttt gat ggt ggc atg gaa 65493
Thr Val Ser Leu Glu Trp Ser Lys Pro Val Phe Asp Gly Gly Met Glu
2177 2178 2178
ata att ggg tat att att gaa atg tgt aag acc gac tta gga gac tgg 65541
Ile Ile Gly Tyr Ile Ile Glu Met Cys Lys Thr Asp Leu Gly Asp Trp
2179 2179 2180
cac aag gtg aat gca gag gca tgt gtg aaa aca aga tat aca gtc act 65589
His Lys Val Asn Ala Glu Ala Cys Val Lys Thr Arg Tyr Thr Val Thr
2180 2181 2181
gat cta caa gca ggt gaa gaa tac aaa ttc cga gtt agt gct atc aat 65637
Asp Leu Gln Ala Gly Glu Glu Tyr Lys Phe Arg Val Ser Ala Ile Asn
2182 2182 2183 2183
ggt gct gga aaa ggc gac agc tgt gaa gtg act ggc aca att aaa gca 65685
Gly Ala Gly Lys Gly Asp Ser Cys Glu Val Thr Gly Thr Ile Lys Ala
2184 2184 2185
gtt gac cgg tta aca gct cct gag tta gac ata gat gca aac ttc aaa 65733
Val Asp Arg Leu Thr Ala Pro Glu Leu Asp Ile Asp Ala Asn Phe Lys
2185 2186 2186
cag act cat gtt gtt aga gct ggg gcc agt att cgc ctc ttc att gcc 65781
Gln Thr His Val Val Arg Ala Gly Ala Ser Ile Arg Leu Phe Ile Ala
2187 2187 2188
tac caa ggt aga cct act cct aca gct gtg tgg agc aaa cca gac tct 65829
Tyr Gln Gly Arg Pro Thr Pro Thr Ala Val Trp Ser Lys Pro Asp Ser
2188 2189 2189
aac ctt agc ctt cgg gct gat atc cat aca aca gat tcc ttc agc acc 65877
Asn Leu Ser Leu Arg Ala Asp Ile His Thr Thr Asp Ser Phe Ser Thr
2190 2190 2191 2191
ctc act gtg gaa aac tgc aac aga aat gat gca ggg aaa tat acc ctt 65925
Leu Thr Val Glu Asn Cys Asn Arg Asn Asp Ala Gly Lys Tyr Thr Leu
2192 2192 2193
act gtg gaa aac aac agt ggt agt aag tca atc aca ttc acc gtg aaa 65973
Thr Val Glu Asn Asn Ser Gly Ser Lys Ser Ile Thr Phe Thr Val Lys
2193 2194 2194
gtg cta gac act cca ggc cca cct ggc cca att acc ttc aaa gat gtg 66021
Val Leu Asp Thr Pro Gly Pro Pro Gly Pro Ile Thr Phe Lys Asp Val
2195 2195 2196
acc cgg gga tct gct aca ttg atg tgg gat gcc cct ctt ctt gac ggt 66069
Thr Arg Gly Ser Ala Thr Leu Met Trp Asp Ala Pro Leu Leu Asp Gly
2196 2197 2197
ggt gcc cga atc cat cat tat gtg gta gag aaa cga gag gca agt cgc 66117
Gly Ala Arg Ile His His Tyr Val Val Glu Lys Arg Glu Ala Ser Arg
2198 2198 2199 2199
cgt agt tgg cag gtt atc agt gaa aaa tgc act cgt cag atc ttc aag 66165
Arg Ser Trp Gln Val Ile Ser Glu Lys Cys Thr Arg Gln Ile Phe Lys
2200 2200 2201
gtc aat gac ctg gcc gaa ggt gtt ccg tac tat ttc cgt gtt tct gca 66213
Val Asn Asp Leu Ala Glu Gly Val Pro Tyr Tyr Phe Arg Val Ser Ala
2201 2202 2202
gta aat gag tat ggt gtt ggt gag ccc tat gaa atg cca gaa cca att 66261
Val Asn Glu Tyr Gly Val Gly Glu Pro Tyr Glu Met Pro Glu Pro Ile
2203 2203 2204
gta gcc acg gaa cag cct gct cca cct agg aga ctt gat gtt gtt gat 66309
Val Ala Thr Glu Gln Pro Ala Pro Pro Arg Arg Leu Asp Val Val Asp
2204 2205 2205
act agc aaa tcc tcc gca gtc tta gct tgg ctt aaa cct gac cac gat 66357
Thr Ser Lys Ser Ser Ala Val Leu Ala Trp Leu Lys Pro Asp His Asp
2206 2206 2207 2207
gga ggc agc cgg atc act ggc tac ctg ctt gaa atg aga caa aag gga 66405
Gly Gly Ser Arg Ile Thr Gly Tyr Leu Leu Glu Met Arg Gln Lys Gly
2208 2208 2209
tct gac ctc tgg gtt gaa gct ggt cac acc aaa cag cta act ttc aca 66453
Ser Asp Leu Trp Val Glu Ala Gly His Thr Lys Gln Leu Thr Phe Thr
2209 2210 2210
gta gag cgt ctt gtt gag aaa act gaa tat gaa ttc cgt gtg aag gcc 66501
Val Glu Arg Leu Val Glu Lys Thr Glu Tyr Glu Phe Arg Val Lys Ala
2211 2211 2212
aag aat gat gct ggc tat agt gaa ccc aga gaa gcc ttc tct tct gtc 66549
Lys Asn Asp Ala Gly Tyr Ser Glu Pro Arg Glu Ala Phe Ser Ser Val
2212 2213 2213
atc att aag gag cct caa atc gag ccc act gct gac ctc act gga att 66597
Ile Ile Lys Glu Pro Gln Ile Glu Pro Thr Ala Asp Leu Thr Gly Ile
2214 2214 2215 2215
acc aat cag ctt ata act tgc aaa gca gga agc cca ttt acc att gac 66645
Thr Asn Gln Leu Ile Thr Cys Lys Ala Gly Ser Pro Phe Thr Ile Asp
2216 2216 2217
gta cca atc agt ggt cgt cct gcc ccc aaa gta aca tgg aaa ctg gaa 66693
Val Pro Ile Ser Gly Arg Pro Ala Pro Lys Val Thr Trp Lys Leu Glu
2217 2218 2218
gaa atg aga ctt aaa gag aca gat cga gtg agc att aca aca aca aaa 66741
Glu Met Arg Leu Lys Glu Thr Asp Arg Val Ser Ile Thr Thr Thr Lys
2219 2219 2220
gac aga acc aca ctg act gta aag gac agc atg aga ggt gac tct gga 66789
Asp Arg Thr Thr Leu Thr Val Lys Asp Ser Met Arg Gly Asp Ser Gly
2220 2221 2221
aga tac ttc ttg acc ctg gaa aat aca gct ggt gtt aaa aca ttt agc 66837
Arg Tyr Phe Leu Thr Leu Glu Asn Thr Ala Gly Val Lys Thr Phe Ser
2222 2222 2223 2223
gtc aca gtt gtg gtc att gga agg cca ggt cca gta acc ggc ccc att 66885
Val Thr Val Val Val Ile Gly Arg Pro Gly Pro Val Thr Gly Pro Ile
2224 2224 2225
gag gtc tca tct gtc tca gct gaa tcg tgt gtc ctg tca tgg gga gaa 66933
Glu Val Ser Ser Val Ser Ala Glu Ser Cys Val Leu Ser Trp Gly Glu
2225 2226 2226
cct aaa gat gga gga ggc act gaa att act aat tac ata gtt gaa aag 66981
Pro Lys Asp Gly Gly Gly Thr Glu Ile Thr Asn Tyr Ile Val Glu Lys
2227 2227 2228
cgt gaa tcg ggt aca aca gct tgg cag ctt gtc aat tcc agt gtc aag 67029
Arg Glu Ser Gly Thr Thr Ala Trp Gln Leu Val Asn Ser Ser Val Lys
2228 2229 2229
cgc act caa att aaa gtc act cat ctc aca aaa tac atg gaa tat tct 67077
Arg Thr Gln Ile Lys Val Thr His Leu Thr Lys Tyr Met Glu Tyr Ser
2230 2230 2231 2231
ttc cgt gtc agt tca gag aac aga ttt ggt gtc agc aaa cct cta gaa 67125
Phe Arg Val Ser Ser Glu Asn Arg Phe Gly Val Ser Lys Pro Leu Glu
2232 2232 2233
tca gca cca ata att gct gaa cat cca ttt gtc cca cca agc gct cct 67173
Ser Ala Pro Ile Ile Ala Glu His Pro Phe Val Pro Pro Ser Ala Pro
2233 2234 2234
acc aga cct gag gtc tac cat gtg tct gcc aat gcc atg tct att cgt 67221
Thr Arg Pro Glu Val Tyr His Val Ser Ala Asn Ala Met Ser Ile Arg
2235 2235 2236
tgg gaa gaa ccc tac cac gat ggt ggc agt aaa atc att ggc tac tgg 67269
Trp Glu Glu Pro Tyr His Asp Gly Gly Ser Lys Ile Ile Gly Tyr Trp
2236 2237 2237
gtt gag aag aaa gaa cgt aat aca att ctt tgg gtg aaa gaa aac aaa 67317
Val Glu Lys Lys Glu Arg Asn Thr Ile Leu Trp Val Lys Glu Asn Lys
2238 2238 2239 2239
gtg cca tgc tta gag tgc aac tac aaa gta act ggt tta gta gaa gga 67365
Val Pro Cys Leu Glu Cys Asn Tyr Lys Val Thr Gly Leu Val Glu Gly
2240 2240 2241
ctg gaa tat cag ttc aga act tat gca ctc aat gct gca ggt gtt agc 67413
Leu Glu Tyr Gln Phe Arg Thr Tyr Ala Leu Asn Ala Ala Gly Val Ser
2241 2242 2242
aag gcc agc gaa gct tca aga cct ata atg gct caa aat cca gtt gat 67461
Lys Ala Ser Glu Ala Ser Arg Pro Ile Met Ala Gln Asn Pro Val Asp
2243 2243 2244
gca cca ggc aga cca gag gtg aca gat gtc aca aga tca aca gta tca 67509
Ala Pro Gly Arg Pro Glu Val Thr Asp Val Thr Arg Ser Thr Val Ser
2244 2245 2245
ctg att tgg tct gcc cca gcg tat gat gga ggc agc aag gtt gtg ggc 67557
Leu Ile Trp Ser Ala Pro Ala Tyr Asp Gly Gly Ser Lys Val Val Gly
2246 2246 2247 2247
tac atc ata gag cgt aag cca gtc agt gag gta gga gat ggt cgc tgg 67605
Tyr Ile Ile Glu Arg Lys Pro Val Ser Glu Val Gly Asp Gly Arg Trp
2248 2248 2249
ctg aag tgc aac tac acc att gta tct gac aat ttc ttc acc gtg act 67653
Leu Lys Cys Asn Tyr Thr Ile Val Ser Asp Asn Phe Phe Thr Val Thr
2249 2250 2250
gct ctc agt gaa gga gac act tat gag ttc cgt gtg tta gcc aag aat 67701
Ala Leu Ser Glu Gly Asp Thr Tyr Glu Phe Arg Val Leu Ala Lys Asn
2251 2251 2252
gca gca ggc gta att agc aaa ggg tct gaa tct aca ggc cct gtc act 67749
Ala Ala Gly Val Ile Ser Lys Gly Ser Glu Ser Thr Gly Pro Val Thr
2252 2253 2253
tgc cga gat gaa tac gct cca ccc aaa gcc gaa ctg gat gcc cga tta 67797
Cys Arg Asp Glu Tyr Ala Pro Pro Lys Ala Glu Leu Asp Ala Arg Leu
2254 2254 2255 2255
cac ggt gat ctg gtt acc atc aga gca ggt tct gat ctt gtt ctg gat 67845
His Gly Asp Leu Val Thr Ile Arg Ala Gly Ser Asp Leu Val Leu Asp
2256 2256 2257
gct gca gtt ggt ggc aaa cct gaa ccc aaa att atc tgg acc aaa gga 67893
Ala Ala Val Gly Gly Lys Pro Glu Pro Lys Ile Ile Trp Thr Lys Gly
2257 2258 2258
gac aag gag cta gat ctc tgt gaa aaa gtc tct ttg cag tat act ggc 67941
Asp Lys Glu Leu Asp Leu Cys Glu Lys Val Ser Leu Gln Tyr Thr Gly
2259 2259 2260
aaa cga gca act gct gtg atc aag ttc tgt gac aga agt gac agt gga 67989
Lys Arg Ala Thr Ala Val Ile Lys Phe Cys Asp Arg Ser Asp Ser Gly
2260 2261 2261
aaa tac act tta aca gtg aaa aat gcc agc ggg acc aag gcc gtg tct 68037
Lys Tyr Thr Leu Thr Val Lys Asn Ala Ser Gly Thr Lys Ala Val Ser
2262 2262 2263 2263
gtc atg gtc aaa gtg ctt gat tcc cct ggc cca tgt gga aag ctc acc 68085
Val Met Val Lys Val Leu Asp Ser Pro Gly Pro Cys Gly Lys Leu Thr
2264 2264 2265
gtc agc aga gta aca cag gag aag tgc act tta gcc tgg agc ctt ccg 68133
Val Ser Arg Val Thr Gln Glu Lys Cys Thr Leu Ala Trp Ser Leu Pro
2265 2266 2266
cag gaa gac gga gga gca gaa atc act cac tac atc gtg gaa aga cgc 68181
Gln Glu Asp Gly Gly Ala Glu Ile Thr His Tyr Ile Val Glu Arg Arg
2267 2267 2268
gag act agc agg ctc aac tgg gtg att gtt gaa ggc gaa tgc cca acc 68229
Glu Thr Ser Arg Leu Asn Trp Val Ile Val Glu Gly Glu Cys Pro Thr
2268 2269 2269
cta tcc tat gtc gtt acc agg ctc atc aag aac aat gag tac ata ttc 68277
Leu Ser Tyr Val Val Thr Arg Leu Ile Lys Asn Asn Glu Tyr Ile Phe
2270 2270 2271 2271
cga gtg agg gca gta aac aaa tat ggc cct ggt gtg cct gtt gaa tca 68325
Arg Val Arg Ala Val Asn Lys Tyr Gly Pro Gly Val Pro Val Glu Ser
2272 2272 2273
gag cca att gta gcc aga aac tca ttc act att cca tca cca ccc ggc 68373
Glu Pro Ile Val Ala Arg Asn Ser Phe Thr Ile Pro Ser Pro Pro Gly
2273 2274 2274
ata cct gaa gaa gtt ggg act ggc aaa gag cat atc atc att cag tgg 68421
Ile Pro Glu Glu Val Gly Thr Gly Lys Glu His Ile Ile Ile Gln Trp
2275 2275 2276
aca aaa cct gaa tct gat ggt ggc aat gaa atc agc aac tac cta gta 68469
Thr Lys Pro Glu Ser Asp Gly Gly Asn Glu Ile Ser Asn Tyr Leu Val
2276 2277 2277
gac aaa cgt gag aag gag agc ctg cgc tgg aca cgt gtc aac aaa gac 68517
Asp Lys Arg Glu Lys Glu Ser Leu Arg Trp Thr Arg Val Asn Lys Asp
2278 2278 2279 2279
tat gtg gtg tat gat acc agg ctg aag gtg acc agc ctg atg gag ggt 68565
Tyr Val Val Tyr Asp Thr Arg Leu Lys Val Thr Ser Leu Met Glu Gly
2280 2280 2281
tgt gat tac cag ttc cgg gtg acc gca gtg aat gca gct ggt aac agt 68613
Cys Asp Tyr Gln Phe Arg Val Thr Ala Val Asn Ala Ala Gly Asn Ser
2281 2282 2282
gag ccc agc gaa cgt tcc aac ttc atc tca tgc aga gaa cca tca tat 68661
Glu Pro Ser Glu Arg Ser Asn Phe Ile Ser Cys Arg Glu Pro Ser Tyr
2283 2283 2284
acc cct gga cca cct tct gct cca aga gtt gtg gat acc acc aaa cac 68709
Thr Pro Gly Pro Pro Ser Ala Pro Arg Val Val Asp Thr Thr Lys His
2284 2285 2285
agc att agt ttg gca tgg acc aaa ccc atg tac gat ggt ggt act gac 68757
Ser Ile Ser Leu Ala Trp Thr Lys Pro Met Tyr Asp Gly Gly Thr Asp
2286 2286 2287 2287
att gta gga tat gtt ctg gaa atg caa gag aag gac act gat cag tgg 68805
Ile Val Gly Tyr Val Leu Glu Met Gln Glu Lys Asp Thr Asp Gln Trp
2288 2288 2289
tac cga gtg cat acc aat gcc aca ata aga aat act gaa ttc act gtg 68853
Tyr Arg Val His Thr Asn Ala Thr Ile Arg Asn Thr Glu Phe Thr Val
2289 2290 2290
cca gac ctt aaa atg ggc cag aaa tat tcc ttc aga gtt gct gcc gtg 68901
Pro Asp Leu Lys Met Gly Gln Lys Tyr Ser Phe Arg Val Ala Ala Val
2291 2291 2292
aac gtg aag ggt atg agc gaa tac agc gaa tca att gct gaa att gag 68949
Asn Val Lys Gly Met Ser Glu Tyr Ser Glu Ser Ile Ala Glu Ile Glu
2292 2293 2293
ccc gtg gaa aga ata gaa ata cca gat ctt gag ctt gca gat gat cta 68997
Pro Val Glu Arg Ile Glu Ile Pro Asp Leu Glu Leu Ala Asp Asp Leu
2294 2294 2295 2295
aag aag act gtg acc atc agg gct ggg gcc tcc ttg cgc ttg atg gtg 69045
Lys Lys Thr Val Thr Ile Arg Ala Gly Ala Ser Leu Arg Leu Met Val
2296 2296 2297
tct gta tct gga aga cca cct cct gtc ata acg tgg agc aag cag ggc 69093
Ser Val Ser Gly Arg Pro Pro Pro Val Ile Thr Trp Ser Lys Gln Gly
2297 2298 2298
att gac ctt gca agc cgg gca att att gac acc act gag agc tac tca 69141
Ile Asp Leu Ala Ser Arg Ala Ile Ile Asp Thr Thr Glu Ser Tyr Ser
2299 2299 2300
ttg cta ata gtg gac aaa gtt aat cgg tac gat gct gga aaa tac aca 69189
Leu Leu Ile Val Asp Lys Val Asn Arg Tyr Asp Ala Gly Lys Tyr Thr
2300 2301 2301
att gaa gct gaa aac caa tct ggc aag aaa tca gca aca gtc ctt gtt 69237
Ile Glu Ala Glu Asn Gln Ser Gly Lys Lys Ser Ala Thr Val Leu Val
2302 2302 2303 2303
aaa gtc tat gat act cct ggt ccc tgt cct tca gtg aaa gtt aag gaa 69285
Lys Val Tyr Asp Thr Pro Gly Pro Cys Pro Ser Val Lys Val Lys Glu
2304 2304 2305
gta tca aga gat tct gtg act ata act tgg gaa att ccc acg att gat 69333
Val Ser Arg Asp Ser Val Thr Ile Thr Trp Glu Ile Pro Thr Ile Asp
2305 2306 2306
ggt gga gct cca atc aac aat tac atc gtt gag aag cgt gaa gct gct 69381
Gly Gly Ala Pro Ile Asn Asn Tyr Ile Val Glu Lys Arg Glu Ala Ala
2307 2307 2308
atg aga gca ttc aaa aca gta act acc aaa tgc agc aag aca ctt tac 69429
Met Arg Ala Phe Lys Thr Val Thr Thr Lys Cys Ser Lys Thr Leu Tyr
2308 2309 2309
aga att tct gga ctt gta gaa gga acc atg cac tat ttc aga gtg ctg 69477
Arg Ile Ser Gly Leu Val Glu Gly Thr Met His Tyr Phe Arg Val Leu
2310 2310 2311 2311
cca gaa aat att tat ggc att gga gaa cct tgt gaa aca tct gat gca 69525
Pro Glu Asn Ile Tyr Gly Ile Gly Glu Pro Cys Glu Thr Ser Asp Ala
2312 2312 2313
gta ctg gtc tca gaa gtg cct ttg gtg cct gca aag cta gaa gtg gtc 69573
Val Leu Val Ser Glu Val Pro Leu Val Pro Ala Lys Leu Glu Val Val
2313 2314 2314
gat gtc acc aaa tcc act gtt acc ctt gcc tgg gaa aaa cca ctc tac 69621
Asp Val Thr Lys Ser Thr Val Thr Leu Ala Trp Glu Lys Pro Leu Tyr
2315 2315 2316
gat ggt ggt agc cga ctc act gga tat gtt ctc gag gcc tgc aaa gct 69669
Asp Gly Gly Ser Arg Leu Thr Gly Tyr Val Leu Glu Ala Cys Lys Ala
2316 2317 2317
ggc aca gag aga tgg atg aag gtt gtc acc tta aaa ccc aca gtc cta 69717
Gly Thr Glu Arg Trp Met Lys Val Val Thr Leu Lys Pro Thr Val Leu
2318 2318 2319 2319
gag cac act gtt act tcc tta aat gaa ggt gaa caa tac tta ttt aga 69765
Glu His Thr Val Thr Ser Leu Asn Glu Gly Glu Gln Tyr Leu Phe Arg
2320 2320 2321
ata agg gca caa aat gag aaa ggt gtg tca gaa cca aga gag act gtc 69813
Ile Arg Ala Gln Asn Glu Lys Gly Val Ser Glu Pro Arg Glu Thr Val
2321 2322 2322
aca gcc gtg act gta caa gac ctc aga gtg ttg cca aca atc gat ctt 69861
Thr Ala Val Thr Val Gln Asp Leu Arg Val Leu Pro Thr Ile Asp Leu
2323 2323 2324
tct aca atg cct cag aag acc atc cat gtc cca gct ggc aga cca gta 69909
Ser Thr Met Pro Gln Lys Thr Ile His Val Pro Ala Gly Arg Pro Val
2324 2325 2325
gag ctg gtg ata cct att gct ggc cgt cca cct cct gct gct tcc tgg 69957
Glu Leu Val Ile Pro Ile Ala Gly Arg Pro Pro Pro Ala Ala Ser Trp
2326 2326 2327 2327
ttc ttt gct ggt tct aaa ctg aga gaa tca gag cgt gtc aca gtt gaa 70005
Phe Phe Ala Gly Ser Lys Leu Arg Glu Ser Glu Arg Val Thr Val Glu
2328 2328 2329
act cac act aaa gta gct aaa tta acc atc cgt gaa acc act atc aga 70053
Thr His Thr Lys Val Ala Lys Leu Thr Ile Arg Glu Thr Thr Ile Arg
2329 2330 2330
gat act gga gaa tac aca ctt gaa ttg aag aat gtt acc gga act act 70101
Asp Thr Gly Glu Tyr Thr Leu Glu Leu Lys Asn Val Thr Gly Thr Thr
2331 2331 2332
tca gaa acc att aaa gtt atc att ctt gac aag cct ggt cca cca aca 70149
Ser Glu Thr Ile Lys Val Ile Ile Leu Asp Lys Pro Gly Pro Pro Thr
2332 2333 2333
gga cct att aag att gat gaa att gat gct aca tca att acc att tcc 70197
Gly Pro Ile Lys Ile Asp Glu Ile Asp Ala Thr Ser Ile Thr Ile Ser
2334 2334 2335 2335
tgg gaa cca cct gaa ttg gac ggt ggt gct cca ctg agt ggt tat gtg 70245
Trp Glu Pro Pro Glu Leu Asp Gly Gly Ala Pro Leu Ser Gly Tyr Val
2336 2336 2337
gta gaa caa cgt gac gct cat cgt cca gga tgg ctg ccc gtt tct gaa 70293
Val Glu Gln Arg Asp Ala His Arg Pro Gly Trp Leu Pro Val Ser Glu
2337 2338 2338
tca gtg act agg tcc acg ttt aag ttt acc aga ctc acc gaa gga aat 70341
Ser Val Thr Arg Ser Thr Phe Lys Phe Thr Arg Leu Thr Glu Gly Asn
2339 2339 2340
gag tat gtg ttc cgt gtg gct gca aca aac cgc ttc ggg att ggc tct 70389
Glu Tyr Val Phe Arg Val Ala Ala Thr Asn Arg Phe Gly Ile Gly Ser
2340 2341 2341
tac ttg cag tct gag gtc ata gag tgt cgc agc agc atc cgt att cct 70437
Tyr Leu Gln Ser Glu Val Ile Glu Cys Arg Ser Ser Ile Arg Ile Pro
2342 2342 2343 2343
gga ccc cca gaa aca tta cag ata ttt gat gtt tcc cgt gat ggc atg 70485
Gly Pro Pro Glu Thr Leu Gln Ile Phe Asp Val Ser Arg Asp Gly Met
2344 2344 2345
aca ctt act tgg tac cca cca gag gat gac ggt ggc tcc caa gtg act 70533
Thr Leu Thr Trp Tyr Pro Pro Glu Asp Asp Gly Gly Ser Gln Val Thr
2345 2346 2346
gga tat att gtg gag cgc aaa gaa gtg aga gca gat cga tgg gtc cgt 70581
Gly Tyr Ile Val Glu Arg Lys Glu Val Arg Ala Asp Arg Trp Val Arg
2347 2347 2348
gta aat aaa gta cct gtg aca atg aca cgg tac cgc tcc act ggc ctt 70629
Val Asn Lys Val Pro Val Thr Met Thr Arg Tyr Arg Ser Thr Gly Leu
2348 2349 2349
act gaa ggc tta gaa tat gaa cac cgt gtc aca gcc att aat gca aga 70677
Thr Glu Gly Leu Glu Tyr Glu His Arg Val Thr Ala Ile Asn Ala Arg
2350 2350 2351 2351
ggg tct ggg aaa cca agt cgt cct tcc aaa ccc atc gtt gcc atg gat 70725
Gly Ser Gly Lys Pro Ser Arg Pro Ser Lys Pro Ile Val Ala Met Asp
2352 2352 2353
cca att gct cct cca gga aag cca caa aac cca aga gtt act gat aca 70773
Pro Ile Ala Pro Pro Gly Lys Pro Gln Asn Pro Arg Val Thr Asp Thr
2353 2354 2354
aca agg aca tca gtc tcc ctg gcc tgg agt gtt cca gaa gat gaa gga 70821
Thr Arg Thr Ser Val Ser Leu Ala Trp Ser Val Pro Glu Asp Glu Gly
2355 2355 2356
gga tct aaa gtc aca ggc tac ttg att gaa atg caa aaa gta gat caa 70869
Gly Ser Lys Val Thr Gly Tyr Leu Ile Glu Met Gln Lys Val Asp Gln
2356 2357 2357
cat gaa tgg acc aag tgt aac acc act cca acc aag att cga gag tat 70917
His Glu Trp Thr Lys Cys Asn Thr Thr Pro Thr Lys Ile Arg Glu Tyr
2358 2358 2359 2359
act cta aca cac cta cct cag ggt gca gaa tac agg ttc cgc gtc cta 70965
Thr Leu Thr His Leu Pro Gln Gly Ala Glu Tyr Arg Phe Arg Val Leu
2360 2360 2361
gct tgt aat gct ggt gga cct ggt gag cct gct gag gta cca gga aca 71013
Ala Cys Asn Ala Gly Gly Pro Gly Glu Pro Ala Glu Val Pro Gly Thr
2361 2362 2362
gtc aaa gtc act gaa atg ctt gaa tat cct gat tat gaa ctt gat gaa 71061
Val Lys Val Thr Glu Met Leu Glu Tyr Pro Asp Tyr Glu Leu Asp Glu
2363 2363 2364
aga tac caa gaa ggt atc ttt gta agg caa ggt ggc gtc atc aga ctt 71109
Arg Tyr Gln Glu Gly Ile Phe Val Arg Gln Gly Gly Val Ile Arg Leu
2364 2365 2365
acc ata cca atc aaa gga aaa cca ttc cca ata tgt aaa tgg acc aag 71157
Thr Ile Pro Ile Lys Gly Lys Pro Phe Pro Ile Cys Lys Trp Thr Lys
2366 2366 2367 2367
gaa ggc cag gat att agt aag cgt gcc atg att gca aca tct gaa aca 71205
Glu Gly Gln Asp Ile Ser Lys Arg Ala Met Ile Ala Thr Ser Glu Thr
2368 2368 2369
cac act gag ctt gtg atc aaa gaa gca gac agg ggt gat tct ggc act 71253
His Thr Glu Leu Val Ile Lys Glu Ala Asp Arg Gly Asp Ser Gly Thr
2369 2370 2370
tat gac ctg gtt ctg gaa aat aaa tgt ggc aag aag gct gtc tac atc 71301
Tyr Asp Leu Val Leu Glu Asn Lys Cys Gly Lys Lys Ala Val Tyr Ile
2371 2371 2372
aag gtc agg gtg ata gga agt ccc aac agt cca gaa ggg cca ctg gaa 71349
Lys Val Arg Val Ile Gly Ser Pro Asn Ser Pro Glu Gly Pro Leu Glu
2372 2373 2373
tat gat gac atc caa gtc cgc tct gtg agg gtc agc tgg aga cct cct 71397
Tyr Asp Asp Ile Gln Val Arg Ser Val Arg Val Ser Trp Arg Pro Pro
2374 2374 2375 2375
gct gat gat ggt ggt gct gac atc tta ggc tac atc ctc gag aga cga 71445
Ala Asp Asp Gly Gly Ala Asp Ile Leu Gly Tyr Ile Leu Glu Arg Arg
2376 2376 2377
gaa gtg cct aaa gcc gcc tgg tat acc att gat tcc aga gtc cga ggt 71493
Glu Val Pro Lys Ala Ala Trp Tyr Thr Ile Asp Ser Arg Val Arg Gly
2377 2378 2378
aca tct ctg gtg gta aaa ggc ctc aaa gag aat gta gaa tac cat ttc 71541
Thr Ser Leu Val Val Lys Gly Leu Lys Glu Asn Val Glu Tyr His Phe
2379 2379 2380
cgt gtt tca gca gaa aac cag ttt ggc ata agc aaa ccc ttg aaa tct 71589
Arg Val Ser Ala Glu Asn Gln Phe Gly Ile Ser Lys Pro Leu Lys Ser
2380 2381 2381
gag gaa cca gtc aca cca aaa aca cca ttg aat cct cca gaa cct cca 71637
Glu Glu Pro Val Thr Pro Lys Thr Pro Leu Asn Pro Pro Glu Pro Pro
2382 2382 2383 2383
agc aat cct cca gaa gta ctc gat gta acc aag agt tct gtt agc ttg 71685
Ser Asn Pro Pro Glu Val Leu Asp Val Thr Lys Ser Ser Val Ser Leu
2384 2384 2385
tcc tgg tcc cgg ccc aaa gat gat ggt ggt tct aga gtc aca ggc tac 71733
Ser Trp Ser Arg Pro Lys Asp Asp Gly Gly Ser Arg Val Thr Gly Tyr
2385 2386 2386
tac atc gaa cgc aaa gag aca tcc act gac aag gtg gtc aga cac aac 71781
Tyr Ile Glu Arg Lys Glu Thr Ser Thr Asp Lys Val Val Arg His Asn
2387 2387 2388
aag act cag atc acc acc aca atg tac act gtc aca ggg ctt gtt ccc 71829
Lys Thr Gln Ile Thr Thr Thr Met Tyr Thr Val Thr Gly Leu Val Pro
2388 2389 2389
gat gct gag tat cag ttc cgc atc atc gca cag aat gat gtt ggc ctg 71877
Asp Ala Glu Tyr Gln Phe Arg Ile Ile Ala Gln Asn Asp Val Gly Leu
2390 2390 2391 2391
agt gag acc agc cct gct tct gaa cca gtt gtt tgc aaa gat cca ttt 71925
Ser Glu Thr Ser Pro Ala Ser Glu Pro Val Val Cys Lys Asp Pro Phe
2392 2392 2393
gat aaa cca agc caa cca gga gaa ctt gag att ctt tca ata tcc aaa 71973
Asp Lys Pro Ser Gln Pro Gly Glu Leu Glu Ile Leu Ser Ile Ser Lys
2393 2394 2394
gat agt gtc act cta cag tgg gag aaa cct gaa tgt gat ggt ggt aaa 72021
Asp Ser Val Thr Leu Gln Trp Glu Lys Pro Glu Cys Asp Gly Gly Lys
2395 2395 2396
gaa att ctt gga tac tgg gtt gaa tat aga cag tct gga gac agt gcc 72069
Glu Ile Leu Gly Tyr Trp Val Glu Tyr Arg Gln Ser Gly Asp Ser Ala
2396 2397 2397
tgg aag aag agc aat aag gaa cgt att aag gac aag caa ttc aca ata 72117
Trp Lys Lys Ser Asn Lys Glu Arg Ile Lys Asp Lys Gln Phe Thr Ile
2398 2398 2399 2399
gga ggt ttg ctg gaa gct act gag tat gaa ttc agg gtt ttt gct gag 72165
Gly Gly Leu Leu Glu Ala Thr Glu Tyr Glu Phe Arg Val Phe Ala Glu
2400 2400 2401
aat gag act ggg ctg agc aga cct cgc aga act gct atg tct ata aag 72213
Asn Glu Thr Gly Leu Ser Arg Pro Arg Arg Thr Ala Met Ser Ile Lys
2401 2402 2402
act aaa ctc aca tct gga gag gcc cca gga ata cgc aaa gaa atg aag 72261
Thr Lys Leu Thr Ser Gly Glu Ala Pro Gly Ile Arg Lys Glu Met Lys
2403 2403 2404
gat gtt acc aca aaa ttg ggt gaa gct gct caa ctc tca tgc cag att 72309
Asp Val Thr Thr Lys Leu Gly Glu Ala Ala Gln Leu Ser Cys Gln Ile
2404 2405 2405
gtt gga agg cct ctt cct gac att aaa tgg tac aga ttt ggt aaa gag 72357
Val Gly Arg Pro Leu Pro Asp Ile Lys Trp Tyr Arg Phe Gly Lys Glu
2406 2406 2407 2407
ctc ata caa agc cgg aaa tac aaa atg tct tca gat gga cgc aca cac 72405
Leu Ile Gln Ser Arg Lys Tyr Lys Met Ser Ser Asp Gly Arg Thr His
2408 2408 2409
act ctt aca gta atg aca gag gaa cag gaa gat gaa ggt gtt tat acc 72453
Thr Leu Thr Val Met Thr Glu Glu Gln Glu Asp Glu Gly Val Tyr Thr
2409 2410 2410
tgc ata gcc acc aat gag gtt gga gaa gta gaa acc agt agt aag ctt 72501
Cys Ile Ala Thr Asn Glu Val Gly Glu Val Glu Thr Ser Ser Lys Leu
2411 2411 2412
ctc ctg caa gca aca ccg cag ttc cat cct ggt tac cca ctg aaa gag 72549
Leu Leu Gln Ala Thr Pro Gln Phe His Pro Gly Tyr Pro Leu Lys Glu
2412 2413 2413
aaa tat tat gga gct gtg ggt tcc aca ctt cgg ctt cat gtt atg tac 72597
Lys Tyr Tyr Gly Ala Val Gly Ser Thr Leu Arg Leu His Val Met Tyr
2414 2414 2415 2415
att ggt cgt cca gta cct gcc atg act tgg ttc cat ggt cag aaa ctt 72645
Ile Gly Arg Pro Val Pro Ala Met Thr Trp Phe His Gly Gln Lys Leu
2416 2416 2417
ttg caa aac tca gaa aac att act att gaa aac act gag cac tat act 72693
Leu Gln Asn Ser Glu Asn Ile Thr Ile Glu Asn Thr Glu His Tyr Thr
2417 2418 2418
cat ctt gtc atg aag aat gtc caa cgt aag act cat gct ggg aaa tac 72741
His Leu Val Met Lys Asn Val Gln Arg Lys Thr His Ala Gly Lys Tyr
2419 2419 2420
aaa gtc cag ctc agc aat gtt ttt gga aca gtt gat gcc atc ctt gat 72789
Lys Val Gln Leu Ser Asn Val Phe Gly Thr Val Asp Ala Ile Leu Asp
2420 2421 2421
gtg gaa ata caa gat aaa cca gac aaa cct aca gga cca att gtg atc 72837
Val Glu Ile Gln Asp Lys Pro Asp Lys Pro Thr Gly Pro Ile Val Ile
2422 2422 2423 2423
gaa gct cta ttg aag aac tcc gca gtg atc agc tgg aaa cca ccc gca 72885
Glu Ala Leu Leu Lys Asn Ser Ala Val Ile Ser Trp Lys Pro Pro Ala
2424 2424 2425
gat gac gga ggc tcc tgg atc acc aac tat gtg gtg gaa aaa tgt gag 72933
Asp Asp Gly Gly Ser Trp Ile Thr Asn Tyr Val Val Glu Lys Cys Glu
2425 2426 2426
gcc aag gag ggg gct gaa tgg caa ttg gtg tct tca gcc atc tca gtg 72981
Ala Lys Glu Gly Ala Glu Trp Gln Leu Val Ser Ser Ala Ile Ser Val
2427 2427 2428
aca acc tgt aga att gtg aac ctc aca gaa aat gct ggc tat tac ttc 73029
Thr Thr Cys Arg Ile Val Asn Leu Thr Glu Asn Ala Gly Tyr Tyr Phe
2428 2429 2429
cgg gtt tca gct cag aac act ttc ggc atc agt gac cct cta gaa gtg 73077
Arg Val Ser Ala Gln Asn Thr Phe Gly Ile Ser Asp Pro Leu Glu Val
2430 2430 2431 2431
tcc tca gtt gtg atc att aag agt cca ttt gaa aag cca ggt gct cct 73125
Ser Ser Val Val Ile Ile Lys Ser Pro Phe Glu Lys Pro Gly Ala Pro
2432 2432 2433
ggc aaa cca act att act gct gtc aca aaa gat tct tgt gtt gtg gcc 73173
Gly Lys Pro Thr Ile Thr Ala Val Thr Lys Asp Ser Cys Val Val Ala
2433 2434 2434
tgg aag cca cct gcc agt gat gga ggt gca aag att aga aat tac tac 73221
Trp Lys Pro Pro Ala Ser Asp Gly Gly Ala Lys Ile Arg Asn Tyr Tyr
2435 2435 2436
ctt gag aag cgt gag aag aag cag aat aaa tgg att tct gtg aca aca 73269
Leu Glu Lys Arg Glu Lys Lys Gln Asn Lys Trp Ile Ser Val Thr Thr
2436 2437 2437
gaa gaa att cga gaa act gtc ttt tca gtg aaa aac ctt att gaa ggt 73317
Glu Glu Ile Arg Glu Thr Val Phe Ser Val Lys Asn Leu Ile Glu Gly
2438 2438 2439 2439
ctt gaa tac gag ttt cgt gtg aaa tgt gaa aat cta ggt ggg gaa agt 73365
Leu Glu Tyr Glu Phe Arg Val Lys Cys Glu Asn Leu Gly Gly Glu Ser
2440 2440 2441
gaa tgg agt gaa ata tca gaa ccc atc act ccc aaa tct gat gtc cca 73413
Glu Trp Ser Glu Ile Ser Glu Pro Ile Thr Pro Lys Ser Asp Val Pro
2441 2442 2442
att cag gca cca cac ttt aaa gag gaa ctg aga aat cta aat gtc aga 73461
Ile Gln Ala Pro His Phe Lys Glu Glu Leu Arg Asn Leu Asn Val Arg
2443 2443 2444
tat cag agc aat gct acc ttg gtc tgc aaa gtg act ggt cat cca aaa 73509
Tyr Gln Ser Asn Ala Thr Leu Val Cys Lys Val Thr Gly His Pro Lys
2444 2445 2445
cct atc gtc aaa tgg tac aga caa ggc aaa gaa atc att gca gat gga 73557
Pro Ile Val Lys Trp Tyr Arg Gln Gly Lys Glu Ile Ile Ala Asp Gly
2446 2446 2447 2447
tta aaa tat agg att caa gaa ttt aag ggt ggc tac cac cag ctc atc 73605
Leu Lys Tyr Arg Ile Gln Glu Phe Lys Gly Gly Tyr His Gln Leu Ile
2448 2448 2449
att gca agt gtc aca gat gat gat gcc aca gtt tac caa gtc aga gct 73653
Ile Ala Ser Val Thr Asp Asp Asp Ala Thr Val Tyr Gln Val Arg Ala
2449 2450 2450
acc aac caa ggg gga tct gtg tct ggc act gcc tcc ttg gaa gtg gaa 73701
Thr Asn Gln Gly Gly Ser Val Ser Gly Thr Ala Ser Leu Glu Val Glu
2451 2451 2452
gtt cca gct aag ata cac tta cct aaa act ctt gaa ggc atg gga gca 73749
Val Pro Ala Lys Ile His Leu Pro Lys Thr Leu Glu Gly Met Gly Ala
2452 2453 2453
gtt cat gct ctc cga ggt gaa gtg gtc agc atc aag att cct ttc agt 73797
Val His Ala Leu Arg Gly Glu Val Val Ser Ile Lys Ile Pro Phe Ser
2454 2454 2455 2455
ggc aaa cca gat cct gtg atc acc tgg cag aaa gga caa gat ctc att 73845
Gly Lys Pro Asp Pro Val Ile Thr Trp Gln Lys Gly Gln Asp Leu Ile
2456 2456 2457
gac aat aat ggc cac tac caa gtt att gtc aca aga tcc ttc aca tca 73893
Asp Asn Asn Gly His Tyr Gln Val Ile Val Thr Arg Ser Phe Thr Ser
2457 2458 2458
ctt gtt ttc ccc aat ggg gta gag aga aaa gat gct ggt ttc tat gtg 73941
Leu Val Phe Pro Asn Gly Val Glu Arg Lys Asp Ala Gly Phe Tyr Val
2459 2459 2460
gtc tgt gct aaa aac aga ttt gga att gat cag aag aca gtt gaa ctg 73989
Val Cys Ala Lys Asn Arg Phe Gly Ile Asp Gln Lys Thr Val Glu Leu
2460 2461 2461
gat gtg gct gat gtt cct gac cca ccc aga gga gtc aaa gtt agt gat 74037
Asp Val Ala Asp Val Pro Asp Pro Pro Arg Gly Val Lys Val Ser Asp
2462 2462 2463 2463
gcc tca cga gat tct gtc aac tta aca tgg act gag cca gcc tct gat 74085
Ala Ser Arg Asp Ser Val Asn Leu Thr Trp Thr Glu Pro Ala Ser Asp
2464 2464 2465
ggt ggc agc aaa atc acc aac tac att gtt gaa aaa tgt gca act act 74133
Gly Gly Ser Lys Ile Thr Asn Tyr Ile Val Glu Lys Cys Ala Thr Thr
2465 2466 2466
gca gaa aga tgg ctc cgt gta gga cag gcc cga gaa aca cgt tat acc 74181
Ala Glu Arg Trp Leu Arg Val Gly Gln Ala Arg Glu Thr Arg Tyr Thr
2467 2467 2468
gtg atc aac tta ttt gga aaa aca agt tac cag ttc cgg gta ata gct 74229
Val Ile Asn Leu Phe Gly Lys Thr Ser Tyr Gln Phe Arg Val Ile Ala
2468 2469 2469
gaa aat aaa ttt ggt ctg agc aag cct tca gag cct tca gaa cca acc 74277
Glu Asn Lys Phe Gly Leu Ser Lys Pro Ser Glu Pro Ser Glu Pro Thr
2470 2470 2471 2471
ata acc aaa gaa gat aag acc aga gct atg aac tat gat gaa gag gta 74325
Ile Thr Lys Glu Asp Lys Thr Arg Ala Met Asn Tyr Asp Glu Glu Val
2472 2472 2473
gat gaa acc agg gaa gtc tcc atg act aaa gca tct cac tct tca acc 74373
Asp Glu Thr Arg Glu Val Ser Met Thr Lys Ala Ser His Ser Ser Thr
2473 2474 2474
aag gaa ctc tat gag aaa tat atg att gct gaa gat ctt ggg cgt ggt 74421
Lys Glu Leu Tyr Glu Lys Tyr Met Ile Ala Glu Asp Leu Gly Arg Gly
2475 2475 2476
gag ttt gga att gtc cat cgt tgt gtt gaa aca tcc tca aag aag aca 74469
Glu Phe Gly Ile Val His Arg Cys Val Glu Thr Ser Ser Lys Lys Thr
2476 2477 2477
tac atg gcc aaa ttt gtt aaa gtc aaa ggg act gat cag gtt ttg gta 74517
Tyr Met Ala Lys Phe Val Lys Val Lys Gly Thr Asp Gln Val Leu Val
2478 2478 2479 2479
aag aag gaa att tcc att ctg aat att gct agg cat aga aac atc tta 74565
Lys Lys Glu Ile Ser Ile Leu Asn Ile Ala Arg His Arg Asn Ile Leu
2480 2480 2481
cac ctc cat gaa tca ttt gaa agc atg gaa gaa tta gtt atg atc ttt 74613
His Leu His Glu Ser Phe Glu Ser Met Glu Glu Leu Val Met Ile Phe
2481 2482 2482
gag ttt ata tca gga ctt gac ata ttt gag cgc att aac aca agt gct 74661
Glu Phe Ile Ser Gly Leu Asp Ile Phe Glu Arg Ile Asn Thr Ser Ala
2483 2483 2484
ttt gaa ctt aat gaa aga gaa att gta agt tat gtt cac cag gtc tgt 74709
Phe Glu Leu Asn Glu Arg Glu Ile Val Ser Tyr Val His Gln Val Cys
2484 2485 2485
gaa gca ctt cag ttt tta cac agt cat aat att gga cac ttt gac att 74757
Glu Ala Leu Gln Phe Leu His Ser His Asn Ile Gly His Phe Asp Ile
2486 2486 2487 2487
aga cca gaa aat atc att tac caa acc aga aga agc tct acc att aaa 74805
Arg Pro Glu Asn Ile Ile Tyr Gln Thr Arg Arg Ser Ser Thr Ile Lys
2488 2488 2489
atc ata gaa ttt ggt caa gcc cgt cag ctg aaa cca ggg gac aac ttc 74853
Ile Ile Glu Phe Gly Gln Ala Arg Gln Leu Lys Pro Gly Asp Asn Phe
2489 2490 2490
agg ctt cta ttc act gcc cca gaa tac tat gca cct gaa gtc cac cag 74901
Arg Leu Leu Phe Thr Ala Pro Glu Tyr Tyr Ala Pro Glu Val His Gln
2491 2491 2492
cat gat gtt gtc agc aca gcc aca gac atg tgg tca ctt gga aca ctg 74949
His Asp Val Val Ser Thr Ala Thr Asp Met Trp Ser Leu Gly Thr Leu
2492 2493 2493
gta tat gtg cta ttg agt ggt atc aac cca ttc ctg gct gaa act aac 74997
Val Tyr Val Leu Leu Ser Gly Ile Asn Pro Phe Leu Ala Glu Thr Asn
2494 2494 2495 2495
caa cag atc att gag aat atc atg aat gct gaa tat act ttc gat gag 75045
Gln Gln Ile Ile Glu Asn Ile Met Asn Ala Glu Tyr Thr Phe Asp Glu
2496 2496 2497
gaa gca ttc aaa gag att agc att gaa gcc atg gat ttt gtt gac cgg 75093
Glu Ala Phe Lys Glu Ile Ser Ile Glu Ala Met Asp Phe Val Asp Arg
2497 2498 2498
ttg tta gtg aaa gag agg aaa tct cgc atg aca gca tcg gag gct ctc 75141
Leu Leu Val Lys Glu Arg Lys Ser Arg Met Thr Ala Ser Glu Ala Leu
2499 2499 2500
cag cac cca tgg ttg aag cag aag ata gaa aga gtc agt act aaa gtt 75189
Gln His Pro Trp Leu Lys Gln Lys Ile Glu Arg Val Ser Thr Lys Val
2500 2501 2501
atc aga aca tta aaa cac cgg cgt tat tac cac acc ctg atc aag aaa 75237
Ile Arg Thr Leu Lys His Arg Arg Tyr Tyr His Thr Leu Ile Lys Lys
2502 2502 2503 2503
gac ctc aac atg gtt gtg tca gca gcc cgg atc tcc tgt ggt ggt gca 75285
Asp Leu Asn Met Val Val Ser Ala Ala Arg Ile Ser Cys Gly Gly Ala
2504 2504 2505
att cga tct cag aag gga gtg agt gtt gct aaa gtt aaa gtg gca tcc 75333
Ile Arg Ser Gln Lys Gly Val Ser Val Ala Lys Val Lys Val Ala Ser
2505 2506 2506
att gaa att ggc cca gtt tct ggg cag ata atg cat gca gtt ggt gaa 75381
Ile Glu Ile Gly Pro Val Ser Gly Gln Ile Met His Ala Val Gly Glu
2507 2507 2508
gaa gga gga cat gtc aaa tat gta tgc aaa att gaa aat tat gat cag 75429
Glu Gly Gly His Val Lys Tyr Val Cys Lys Ile Glu Asn Tyr Asp Gln
2508 2509 2509
tct acc caa gtg act tgg tac ttt ggt gtc cga cag ctg gag aac agt 75477
Ser Thr Gln Val Thr Trp Tyr Phe Gly Val Arg Gln Leu Glu Asn Ser
2510 2510 2511 2511
gag aaa tac gaa atc acc tac gaa gat gga gtg gcc atc ctc tat gtc 75525
Glu Lys Tyr Glu Ile Thr Tyr Glu Asp Gly Val Ala Ile Leu Tyr Val
2512 2512 2513
aaa gac att acc aaa tta gat gat ggt acc tac aga tgc aaa gta gtc 75573
Lys Asp Ile Thr Lys Leu Asp Asp Gly Thr Tyr Arg Cys Lys Val Val
2513 2514 2514
aat gac tat ggt gaa gac agt tct tat gca gag cta ttt gtt aaa ggt 75621
Asn Asp Tyr Gly Glu Asp Ser Ser Tyr Ala Glu Leu Phe Val Lys Gly
2515 2515 2516
gtg aga gaa gtc tat gac tat tac tgc cgt aga acc atg aag aaa att 75669
Val Arg Glu Val Tyr Asp Tyr Tyr Cys Arg Arg Thr Met Lys Lys Ile
2516 2517 2517
aag cgc aga aca gac aca atg aga ctc ctg gaa agg cca cca gaa ttt 75717
Lys Arg Arg Thr Asp Thr Met Arg Leu Leu Glu Arg Pro Pro Glu Phe
2518 2518 2519 2519
acc ctg cct ctc tat aat aag aca gct tat gta ggt gaa aat gtc cgg 75765
Thr Leu Pro Leu Tyr Asn Lys Thr Ala Tyr Val Gly Glu Asn Val Arg
2520 2520 2521
ttt gga gta act ata act gtc cac cca gag cct cat gta aca tgg tat 75813
Phe Gly Val Thr Ile Thr Val His Pro Glu Pro His Val Thr Trp Tyr
2521 2522 2522
aaa tca ggt cag aaa atc aaa cca ggt gac aat gac aag aag tac aca 75861
Lys Ser Gly Gln Lys Ile Lys Pro Gly Asp Asn Asp Lys Lys Tyr Thr
2523 2523 2524
ttt gag tca gac aag ggt ctt tac caa tta aca atc aac agt gtc act 75909
Phe Glu Ser Asp Lys Gly Leu Tyr Gln Leu Thr Ile Asn Ser Val Thr
2524 2525 2525
aca gat gat gac gct gaa tat act gtt gtg gca agg aac aaa tat ggt 75957
Thr Asp Asp Asp Ala Glu Tyr Thr Val Val Ala Arg Asn Lys Tyr Gly
2526 2526 2527 2527
gaa gac agc tgt aaa gca aag ctg aca gta acc cta cac cca cct cca 76005
Glu Asp Ser Cys Lys Ala Lys Leu Thr Val Thr Leu His Pro Pro Pro
2528 2528 2529
aca gat agt acc tta aga ccc atg ttc aaa agg tta ctg gca aat gca 76053
Thr Asp Ser Thr Leu Arg Pro Met Phe Lys Arg Leu Leu Ala Asn Ala
2529 2530 2530
gaa tgc caa gaa ggc caa agt gtc tgc ttt gag atc aga gtg tct ggc 76101
Glu Cys Gln Glu Gly Gln Ser Val Cys Phe Glu Ile Arg Val Ser Gly
2531 2531 2532
atc ccc cca cca aca tta aaa tgg gag aaa gat ggt cag cca ctg tcc 76149
Ile Pro Pro Pro Thr Leu Lys Trp Glu Lys Asp Gly Gln Pro Leu Ser
2532 2533 2533
ctc ggg cct aac att gaa att atc cat gaa ggc ttg gat tat tat gct 76197
Leu Gly Pro Asn Ile Glu Ile Ile His Glu Gly Leu Asp Tyr Tyr Ala
2534 2534 2535 2535
ctg cac atc agg gac act ttg cct gaa gac acg ggt tat tat aga gtc 76245
Leu His Ile Arg Asp Thr Leu Pro Glu Asp Thr Gly Tyr Tyr Arg Val
2536 2536 2537
aca gcc act aac aca gct ggg tcc acc agc tgc cag gct cac cta caa 76293
Thr Ala Thr Asn Thr Ala Gly Ser Thr Ser Cys Gln Ala His Leu Gln
2537 2538 2538
gtg gaa cgc ctg agg tac aag aaa cag gaa ttc aag agt aag gag gag 76341
Val Glu Arg Leu Arg Tyr Lys Lys Gln Glu Phe Lys Ser Lys Glu Glu
2539 2539 2540
cat gag cga cac gta caa aaa caa att gac aaa acc ctc aga atg gct 76389
His Glu Arg His Val Gln Lys Gln Ile Asp Lys Thr Leu Arg Met Ala
2540 2541 2541
gaa att ctt tct gga act gaa agt gta cca ctg aca cag gta gct aaa 76437
Glu Ile Leu Ser Gly Thr Glu Ser Val Pro Leu Thr Gln Val Ala Lys
2542 2542 2543 2543
gag gct ctg aga gaa gct gct gtc ctt tat aaa ccg gct gta agc acc 76485
Glu Ala Leu Arg Glu Ala Ala Val Leu Tyr Lys Pro Ala Val Ser Thr
2544 2544 2545
aag act gta aaa ggg gaa ttc aga ctt gag ata gaa gaa aag aag gag 76533
Lys Thr Val Lys Gly Glu Phe Arg Leu Glu Ile Glu Glu Lys Lys Glu
2545 2546 2546
gag aga aaa ctc cgg atg cct tat gat gta cca gag cca cgc aag tat 76581
Glu Arg Lys Leu Arg Met Pro Tyr Asp Val Pro Glu Pro Arg Lys Tyr
2547 2547 2548
aag cag act acc ata gaa gaa gac caa cgc atc aag cag ttc gtg ccc 76629
Lys Gln Thr Thr Ile Glu Glu Asp Gln Arg Ile Lys Gln Phe Val Pro
2548 2549 2549
atg tct gac atg aag tgg tat aaa aag ata cgt gat cag tat gaa atg 76677
Met Ser Asp Met Lys Trp Tyr Lys Lys Ile Arg Asp Gln Tyr Glu Met
2550 2550 2551 2551
cct ggg aaa ctt gac aga gtt gta cag aaa cga ccc aag cgc atc cgc 76725
Pro Gly Lys Leu Asp Arg Val Val Gln Lys Arg Pro Lys Arg Ile Arg
2552 2552 2553
ctt tca aga tgg gaa cag ttc tat gtg atg cct ctt cca cgc att aca 76773
Leu Ser Arg Trp Glu Gln Phe Tyr Val Met Pro Leu Pro Arg Ile Thr
2553 2554 2554
gat caa tac aga cct aaa tgg cgt att cct aaa ctg tcc caa gat gat 76821
Asp Gln Tyr Arg Pro Lys Trp Arg Ile Pro Lys Leu Ser Gln Asp Asp
2555 2555 2556
ctt gag ata gtg aga cca gcc cgc cgg cgt aca cct tct cct gat tat 76869
Leu Glu Ile Val Arg Pro Ala Arg Arg Arg Thr Pro Ser Pro Asp Tyr
2556 2557 2557
gac ttt tac tac cga cct aga aga cgt tct ctt ggg gac atc tct gat 76917
Asp Phe Tyr Tyr Arg Pro Arg Arg Arg Ser Leu Gly Asp Ile Ser Asp
2558 2558 2559 2559
gaa gaa tta ctc ctc ccc att gat gac tac tta gca atg aaa aga aca 76965
Glu Glu Leu Leu Leu Pro Ile Asp Asp Tyr Leu Ala Met Lys Arg Thr
2560 2560 2561
gag gaa gag agg ctg cgt ctt gaa gaa gag ctt gag tta ggt ttt tca 77013
Glu Glu Glu Arg Leu Arg Leu Glu Glu Glu Leu Glu Leu Gly Phe Ser
2561 2562 2562
gct tca ccc cca agt cga agc cct cca cac ttt gag ctt tct agc cta 77061
Ala Ser Pro Pro Ser Arg Ser Pro Pro His Phe Glu Leu Ser Ser Leu
2563 2563 2564
cgt tac tct tca cca caa gct cat gtc aag gtg gag gaa aca aga aaa 77109
Arg Tyr Ser Ser Pro Gln Ala His Val Lys Val Glu Glu Thr Arg Lys
2564 2565 2565
aac ttc agg tat tca acc tat cac atc cca acg aag gct gaa gct agt 77157
Asn Phe Arg Tyr Ser Thr Tyr His Ile Pro Thr Lys Ala Glu Ala Ser
2566 2566 2567 2567
aca agt tat gca gaa ctg agg gaa cgg cat gcc cag gct gcg tac aga 77205
Thr Ser Tyr Ala Glu Leu Arg Glu Arg His Ala Gln Ala Ala Tyr Arg
2568 2568 2569
cag cca aag caa cgg caa aga atc atg gct gag agg gag gat gaa gag 77253
Gln Pro Lys Gln Arg Gln Arg Ile Met Ala Glu Arg Glu Asp Glu Glu
2569 2570 2570
ttg ctt cgc cca gtt acg acc acc cag cat ctc tca gaa tac aaa agc 77301
Leu Leu Arg Pro Val Thr Thr Thr Gln His Leu Ser Glu Tyr Lys Ser
2571 2571 2572
gaa ctt gac ttc atg tca aag gag gaa aag tct aga aag aaa tca agg 77349
Glu Leu Asp Phe Met Ser Lys Glu Glu Lys Ser Arg Lys Lys Ser Arg
2572 2573 2573
cga caa aga gaa gtg aca gaa ata aca gaa att gag gaa gaa tac gaa 77397
Arg Gln Arg Glu Val Thr Glu Ile Thr Glu Ile Glu Glu Glu Tyr Glu
2574 2574 2575 2575
atc tca aaa cat gct caa aga gaa tca tcc tca tct gcg tct aga cta 77445
Ile Ser Lys His Ala Gln Arg Glu Ser Ser Ser Ser Ala Ser Arg Leu
2576 2576 2577
ctg aga cga cgg cgc tcc ctg tct cca act tat att gag tta atg agg 77493
Leu Arg Arg Arg Arg Ser Leu Ser Pro Thr Tyr Ile Glu Leu Met Arg
2577 2578 2578
cca gtg tct gag ctg atc cgg tca cgt cca caa ccg gct gag gaa tac 77541
Pro Val Ser Glu Leu Ile Arg Ser Arg Pro Gln Pro Ala Glu Glu Tyr
2579 2579 2580
gaa gat gac aca gaa aga agg tca cct act cca gag aga act cgc cca 77589
Glu Asp Asp Thr Glu Arg Arg Ser Pro Thr Pro Glu Arg Thr Arg Pro
2580 2581 2581
cga tcc ccc agc cct gtg tct agt gag aga tca ctc tcg aga ttt gag 77637
Arg Ser Pro Ser Pro Val Ser Ser Glu Arg Ser Leu Ser Arg Phe Glu
2582 2582 2583 2583
agg tct gca aga ttt gat atc ttt tcc agg tat gag tcc atg aaa gct 77685
Arg Ser Ala Arg Phe Asp Ile Phe Ser Arg Tyr Glu Ser Met Lys Ala
2584 2584 2585
gct tta aaa act cag aag aca tca gaa agg aag tat gaa gtt ttg agt 77733
Ala Leu Lys Thr Gln Lys Thr Ser Glu Arg Lys Tyr Glu Val Leu Ser
2585 2586 2586
cag cag cct ttc aca ctg gac cat gcc cct cga atc aca ctg aga atg 77781
Gln Gln Pro Phe Thr Leu Asp His Ala Pro Arg Ile Thr Leu Arg Met
2587 2587 2588
cgc tcg cac agg gta cca tgt ggc caa aat aca cgt ttt att tta aat 77829
Arg Ser His Arg Val Pro Cys Gly Gln Asn Thr Arg Phe Ile Leu Asn
2588 2589 2589
gtt cag tct aag cca act gcc gaa gtt aaa tgg tac cac aat ggt gtg 77877
Val Gln Ser Lys Pro Thr Ala Glu Val Lys Trp Tyr His Asn Gly Val
2590 2590 2591 2591
gaa ctc caa gaa agc agt aag att cat tac acc aac acg agt gga gtt 77925
Glu Leu Gln Glu Ser Ser Lys Ile His Tyr Thr Asn Thr Ser Gly Val
2592 2592 2593
ctc acc ctg gaa att ctg gac tgt cat act gat gac agt gga acc tac 77973
Leu Thr Leu Glu Ile Leu Asp Cys His Thr Asp Asp Ser Gly Thr Tyr
2593 2594 2594
cgt gct gtg tgc acc aac tac aag ggc gaa gct tct gac tat gca acg 78021
Arg Ala Val Cys Thr Asn Tyr Lys Gly Glu Ala Ser Asp Tyr Ala Thr
2595 2595 2596
ttg gac gtg aca gga ggg gat tat acc acc tat gct tcc caa cgc aga 78069
Leu Asp Val Thr Gly Gly Asp Tyr Thr Thr Tyr Ala Ser Gln Arg Arg
2596 2597 2597
gat gaa gag gtc ccc aga tct gtt ttc cct gag ctg aca aga aca gag 78117
Asp Glu Glu Val Pro Arg Ser Val Phe Pro Glu Leu Thr Arg Thr Glu
2598 2598 2599 2599
gcg tat gct gtt cca tca ttt aag aaa aca tct gag atg gaa gct tcg 78165
Ala Tyr Ala Val Pro Ser Phe Lys Lys Thr Ser Glu Met Glu Ala Ser
2600 2600 2601
tct tct gtc agg gaa gtg aaa tca cag atg acg gag aca agg gaa agt 78213
Ser Ser Val Arg Glu Val Lys Ser Gln Met Thr Glu Thr Arg Glu Ser
2601 2602 2602
ctc tcc tca tat gaa cac tct gca tct gca gaa atg aaa agt gct gca 78261
Leu Ser Ser Tyr Glu His Ser Ala Ser Ala Glu Met Lys Ser Ala Ala
2603 2603 2604
tta gaa gaa aag tca ctg gaa gaa aaa tcc aca acc aga aag atc aag 78309
Leu Glu Glu Lys Ser Leu Glu Glu Lys Ser Thr Thr Arg Lys Ile Lys
2604 2605 2605
acg act ttg gcg gca aga att cta aca aag cca cgg tcc atg acc gtc 78357
Thr Thr Leu Ala Ala Arg Ile Leu Thr Lys Pro Arg Ser Met Thr Val
2606 2606 2607 2607
tac gag ggc gag tct gca agg ttt tct tgt gac acc gat ggt gag ccg 78405
Tyr Glu Gly Glu Ser Ala Arg Phe Ser Cys Asp Thr Asp Gly Glu Pro
2608 2608 2609
gta cca act gtg acc tgg ctg cgt aaa gga caa gtg cta agt act tct 78453
Val Pro Thr Val Thr Trp Leu Arg Lys Gly Gln Val Leu Ser Thr Ser
2609 2610 2610
gcc cgc cac caa gtg acc acc aca aag tac aaa tca acc ttt gag atc 78501
Ala Arg His Gln Val Thr Thr Thr Lys Tyr Lys Ser Thr Phe Glu Ile
2611 2611 2612
tct tca gtc cag gct tcc gat gag ggc aat tac agc gtg gtg gta gaa 78549
Ser Ser Val Gln Ala Ser Asp Glu Gly Asn Tyr Ser Val Val Val Glu
2612 2613 2613
aac agt gaa ggg aaa caa gaa gca gag ttc act ctg act att caa aag 78597
Asn Ser Glu Gly Lys Gln Glu Ala Glu Phe Thr Leu Thr Ile Gln Lys
2614 2614 2615 2615
gcc agg gta act gaa aag gct gtg aca tca cca cca aga gtc aaa tcc 78645
Ala Arg Val Thr Glu Lys Ala Val Thr Ser Pro Pro Arg Val Lys Ser
2616 2616 2617
cca gag cct cgg gtg aaa tcc cca gaa gca gtt aag tct cca aaa cga 78693
Pro Glu Pro Arg Val Lys Ser Pro Glu Ala Val Lys Ser Pro Lys Arg
2617 2618 2618
gtg aaa tct cca gaa cct tct cac ccg aaa gcc gta tca ccc aca gag 78741
Val Lys Ser Pro Glu Pro Ser His Pro Lys Ala Val Ser Pro Thr Glu
2619 2619 2620
aca aaa cca aca cca aga gag aaa gtt cag cac ctc cca gtc tct gcc 78789
Thr Lys Pro Thr Pro Arg Glu Lys Val Gln His Leu Pro Val Ser Ala
2620 2621 2621
cca cca aag att act cag ttc ctg aaa gca gaa gct tct aaa gag att 78837
Pro Pro Lys Ile Thr Gln Phe Leu Lys Ala Glu Ala Ser Lys Glu Ile
2622 2622 2623 2623
gca aaa ctg acc tgt gtg gtt gaa agc agt gta tta agg gca aaa gag 78885
Ala Lys Leu Thr Cys Val Val Glu Ser Ser Val Leu Arg Ala Lys Glu
2624 2624 2625
gtc acc tgg tat aaa gat ggc aag aaa ctg aag gaa aat ggg cat ttc 78933
Val Thr Trp Tyr Lys Asp Gly Lys Lys Leu Lys Glu Asn Gly His Phe
2625 2626 2626
cag ttt cat tat tca gca gat ggt acc tat gag ctc aaa atc aat aac 78981
Gln Phe His Tyr Ser Ala Asp Gly Thr Tyr Glu Leu Lys Ile Asn Asn
2627 2627 2628
ctc act gaa tct gat caa gga gaa tat gtt tgt gag att tct ggt gaa 79029
Leu Thr Glu Ser Asp Gln Gly Glu Tyr Val Cys Glu Ile Ser Gly Glu
2628 2629 2629
ggt gga acg tct aaa acc aac tta caa ttt atg ggg caa gcc ttt aag 79077
Gly Gly Thr Ser Lys Thr Asn Leu Gln Phe Met Gly Gln Ala Phe Lys
2630 2630 2631 2631
agt atc cat gag aag gta tca aaa ata tca gaa act aag aaa tca gat 79125
Ser Ile His Glu Lys Val Ser Lys Ile Ser Glu Thr Lys Lys Ser Asp
2632 2632 2633
cag aaa acc act gag tca aca gta acc aga aaa act gaa cca aaa gct 79173
Gln Lys Thr Thr Glu Ser Thr Val Thr Arg Lys Thr Glu Pro Lys Ala
2633 2634 2634
cct gaa cca att tcc tca aaa cca gta att gtt act ggg ttg cag gat 79221
Pro Glu Pro Ile Ser Ser Lys Pro Val Ile Val Thr Gly Leu Gln Asp
2635 2635 2636
aca act gtt tct tca gac agt gtt gct aaa ttt gca gtt aag gct act 79269
Thr Thr Val Ser Ser Asp Ser Val Ala Lys Phe Ala Val Lys Ala Thr
2636 2637 2637
gga gaa ccc cgg cca act gcc atc tgg aca aaa gat gga aag gcc att 79317
Gly Glu Pro Arg Pro Thr Ala Ile Trp Thr Lys Asp Gly Lys Ala Ile
2638 2638 2639 2639
aca caa gga ggt aaa tat aaa ctc tct gaa gac aag gga ggg ttc ttc 79365
Thr Gln Gly Gly Lys Tyr Lys Leu Ser Glu Asp Lys Gly Gly Phe Phe
2640 2640 2641
tta gaa att cat aag act gat act tct gac agt gga ctt tat act tgt 79413
Leu Glu Ile His Lys Thr Asp Thr Ser Asp Ser Gly Leu Tyr Thr Cys
2641 2642 2642
aca gta aaa aat tca gct gga tct gtg tcc tct agc tgc aaa tta aca 79461
Thr Val Lys Asn Ser Ala Gly Ser Val Ser Ser Ser Cys Lys Leu Thr
2643 2643 2644
ata aaa gct ata aaa gat act gag gca cag aaa gtc tct aca caa aag 79509
Ile Lys Ala Ile Lys Asp Thr Glu Ala Gln Lys Val Ser Thr Gln Lys
2644 2645 2645
act tct gaa att aca cct cag aag aaa gct gtt gtc caa gag gaa att 79557
Thr Ser Glu Ile Thr Pro Gln Lys Lys Ala Val Val Gln Glu Glu Ile
2646 2646 2647 2647
tcc caa aaa gcc cta agg tct gaa gaa att aag atg tca gag gca aaa 79605
Ser Gln Lys Ala Leu Arg Ser Glu Glu Ile Lys Met Ser Glu Ala Lys
2648 2648 2649
tct caa gaa aag tta gcc ctc aaa gag gaa gct tca aag gtt ctg att 79653
Ser Gln Glu Lys Leu Ala Leu Lys Glu Glu Ala Ser Lys Val Leu Ile
2649 2650 2650
tct gaa gaa gtc aag aaa tca gca gca acc tcc ctg gaa aaa tcc att 79701
Ser Glu Glu Val Lys Lys Ser Ala Ala Thr Ser Leu Glu Lys Ser Ile
2651 2651 2652
gtc cat gag gaa atc act aaa aca tca cag gca tca gaa gaa gtc aga 79749
Val His Glu Glu Ile Thr Lys Thr Ser Gln Ala Ser Glu Glu Val Arg
2652 2653 2653
act cat gct gag att aaa gca ttt tct act cag atg agc ata aac gaa 79797
Thr His Ala Glu Ile Lys Ala Phe Ser Thr Gln Met Ser Ile Asn Glu
2654 2654 2655 2655
ggt caa aga ctg gtt tta aaa gcc aac att gct ggt gcc act gat gtg 79845
Gly Gln Arg Leu Val Leu Lys Ala Asn Ile Ala Gly Ala Thr Asp Val
2656 2656 2657
aaa tgg gta ctg aat ggc gta gag ctt acc aac tct gag gag tac cga 79893
Lys Trp Val Leu Asn Gly Val Glu Leu Thr Asn Ser Glu Glu Tyr Arg
2657 2658 2658
tat ggt gtc tca ggc agc gat cag acc cta acc atc aag caa gcc agt 79941
Tyr Gly Val Ser Gly Ser Asp Gln Thr Leu Thr Ile Lys Gln Ala Ser
2659 2659 2660
cac aga gat gaa gga atc ctc acc tgc ata agc aaa acc aag gaa gga 79989
His Arg Asp Glu Gly Ile Leu Thr Cys Ile Ser Lys Thr Lys Glu Gly
2660 2661 2661
atc gtc aag tgt cag tat gat ttg aca ctg agc aaa gaa ctc tca gat 80037
Ile Val Lys Cys Gln Tyr Asp Leu Thr Leu Ser Lys Glu Leu Ser Asp
2662 2662 2663 2663
gct cca gcc ttc atc tca cag cct aga tct caa aat att aat gaa gga 80085
Ala Pro Ala Phe Ile Ser Gln Pro Arg Ser Gln Asn Ile Asn Glu Gly
2664 2664 2665
caa aat gtt ctc ttt act tgt gaa atc agt ggc gag cca tcc cct gaa 80133
Gln Asn Val Leu Phe Thr Cys Glu Ile Ser Gly Glu Pro Ser Pro Glu
2665 2666 2666
atc gaa tgg ttt aaa aac aac ctg cca att tct att tct tca aat gtc 80181
Ile Glu Trp Phe Lys Asn Asn Leu Pro Ile Ser Ile Ser Ser Asn Val
2667 2667 2668
agc ata agc cgc tcc aga aat gta tac tcc ctt gaa atc cga aat gca 80229
Ser Ile Ser Arg Ser Arg Asn Val Tyr Ser Leu Glu Ile Arg Asn Ala
2668 2669 2669
tca gtc agc gac agt gga aag tac aca att aag gcc aaa aat ttc cgt 80277
Ser Val Ser Asp Ser Gly Lys Tyr Thr Ile Lys Ala Lys Asn Phe Arg
2670 2670 2671 2671
ggc cag tgt tca gct aca gct tcc tta atg gtc ctt cct cta gtt gaa 80325
Gly Gln Cys Ser Ala Thr Ala Ser Leu Met Val Leu Pro Leu Val Glu
2672 2672 2673
gaa cct tcc aga gag gta gta ttg aga aca agt ggt gac aca agc ttg 80373
Glu Pro Ser Arg Glu Val Val Leu Arg Thr Ser Gly Asp Thr Ser Leu
2673 2674 2674
caa gga agc ttc tcg tct cag tca gtc caa atg tct gcc tcc aag cag 80421
Gln Gly Ser Phe Ser Ser Gln Ser Val Gln Met Ser Ala Ser Lys Gln
2675 2675 2676
gag gcc tcc ttc agc agt ttc agc agc agc agt gct agc agc atg act 80469
Glu Ala Ser Phe Ser Ser Phe Ser Ser Ser Ser Ala Ser Ser Met Thr
2676 2677 2677
gag atg aaa ttt gca agc atg tct gcc caa agc atg tcc tcc atg caa 80517
Glu Met Lys Phe Ala Ser Met Ser Ala Gln Ser Met Ser Ser Met Gln
2678 2678 2679 2679
gag tcc ttt gta gaa atg agt tcc agc agc ttt atg gga ata tct aat 80565
Glu Ser Phe Val Glu Met Ser Ser Ser Ser Phe Met Gly Ile Ser Asn
2680 2680 2681
atg aca caa ctg gaa agc tca act agt aaa atg ctt aaa gca ggc ata 80613
Met Thr Gln Leu Glu Ser Ser Thr Ser Lys Met Leu Lys Ala Gly Ile
2681 2682 2682
aga gga att ccg cct aaa att gaa gct ctt cca tct gat atc agc att 80661
Arg Gly Ile Pro Pro Lys Ile Glu Ala Leu Pro Ser Asp Ile Ser Ile
2683 2683 2684
gat gaa ggc aaa gtt cta aca gta gcc tgt gct ttc acg ggt gag cct 80709
Asp Glu Gly Lys Val Leu Thr Val Ala Cys Ala Phe Thr Gly Glu Pro
2684 2685 2685
acc cca gaa gta aca tgg tcc tgt ggt gga aga aaa atc cac agt caa 80757
Thr Pro Glu Val Thr Trp Ser Cys Gly Gly Arg Lys Ile His Ser Gln
2686 2686 2687 2687
gaa cag ggg agg ttc cac att gaa aac aca gat gac ctg aca acc ctg 80805
Glu Gln Gly Arg Phe His Ile Glu Asn Thr Asp Asp Leu Thr Thr Leu
2688 2688 2689
atc atc atg gac gta cag aaa caa gat ggt gga ctt tat acc ctg agt 80853
Ile Ile Met Asp Val Gln Lys Gln Asp Gly Gly Leu Tyr Thr Leu Ser
2689 2690 2690
tta ggg aat gaa ttt gga tct gac tct gcc act gtg aat ata cat att 80901
Leu Gly Asn Glu Phe Gly Ser Asp Ser Ala Thr Val Asn Ile His Ile
2691 2691 2692
cga tcc att taagagggcc tgtgccttat actctacact cattcttaac 80950
Arg Ser Ile
2692
ttttcgcaaa cgtttcacac ggactaatct ttctgaactg taaatattta aagaaaaaaa 81010
gtagttttgt atcaacctaa atgagtcaaa gttcaaaaat attcatttca atcttttcat 81070
aattgttgac ctaagaatat aatacatttg ctagtgacat gtacatactg tatatagccg 81130
gattaacggt tataaagttt tgtaccattt attttatgac attttacaat gtaagttttg 81190
aaactaactg ttggtaggag aaagtttctt atggaacgaa taccctgctc aacatttaat 81250
caatctttgt gcctcaacat actgttgatg tctaagtatg cctcagtggg ttgagaaaat 81310
ccccattgaa gatgtcctgt ccacctaaaa gagaatgatg ctgtgcatat cacttgatat 81370
gtgcaccaat acctactgaa tcagaaatgt aaggcattgg tgatgtttgc atttaccctc 81430
ctgtaagcaa cactttaacg tcttacattt tctctgatga tgtcacacaa aattatcatg 81490
acaaatatta ccagagcaaa gtgtaacggc caacactttg ttcgctcatt ttacgctgtc 81550
tctgacataa ggagtgcctg aatagcttgg aaaagtaaca tctcctggcc atcccttcat 81610
ttaaccaagc tattcaagta ttcctatgcc agagcagtgc caactcttgg aggtcccaga 81670
gtgcagccaa tgcctttgtg tggtagttct aaattttaat tgcacctgaa aaacctgggc 81730
acctaagcaa tgagccacag caaaaagtaa agaacaacaa caaaataaag ctgttgttaa 81790
attttaaaca atattactaa ttgcccaaaa tgtcaatttg atgtagttct tttcatgcaa 81850
gtataaattc aattgttagt tataattgtt ggacctcctt gagatagtaa caacaaaata 81910
aagcaagcta tctgcacctc aaaaaaaaaa 81940
Claims (11)
- 서열목록 제1서열의 단백질 및 서열목록 제5서열의 단백질로 구성된 군으로부터 선택되는 단백질에 특이적으로 결합하는 결합제 또는 서열목록 제2서열의 폴리뉴클레오타이드 및 서열목록 제6서열의 폴리뉴클레오타이드로 구성된 군으로부터 선택되는 폴리뉴클레오타이드에 특이적으로 결합하는 프라이머 또는 프로브를 포함하는 간암 진단 또는 예후 분석용 키트.
- 삭제
- 서열목록 제1서열의 단백질 및 서열목록 제5서열의 단백질로 구성된 군으로부터 선택되는 단백질에 특이적으로 결합하는 결합제 또는 서열목록 제2서열의 폴리뉴클레오타이드 및 서열목록 제6서열의폴리뉴클레오타이드로 구성된 군으로부터 선택되는 폴리뉴클레오타이드에 특이적으로 결합하는 프라이머 또는 프로브를 포함하는 간암 암 줄기세포 검출용 키트.
- 삭제
- 제 1 항 또는 제 3 항 중 어느 한 항에 있어서, 상기 키트는 면역분석(immunoassay)용 키트인 것을 특징으로 하는 키트.
- 제 1 항 또는 제 3 항 중 어느 한 항에 있어서, 상기 키트는 유전자 증폭 또는 마이크로어레이용 키트인 것을 특징으로 하는 키트.
- 다음의 단계를 포함하는 간암 예방 또는 치료용 물질의 스크리닝 방법:
(a) 서열목록 제1서열의 단백질 및 서열목록 제5서열의 단백질로 구성된 군으로부터 선택되는 단백질 또는 서열목록 제2서열의 폴리뉴클레오타이드 및 서열목록 제6서열의 폴리뉴클레오타이드로 구성된 군으로부터 선택되는 폴리뉴클레오타이드를 포함하는 세포 또는 조직에 분석하고자 하는 시료를 접촉시키는 단계; 및
(b) 상기 단계 (a)에서의 상기 단백질 또는 폴리뉴클레오타이드의 발현량을 측정하는 단계로서, 상기 시료가 상기 단백질 또는 폴리뉴클레오타이드의 발현을 감소시키는 경우에는 상기 시료는 간암의 예방 또는 치료용 물질로 판정된다.
- 다음의 단계를 포함하는 간암 예방 또는 치료용 물질의 스크리닝 방법:
(a) 서열목록 제1서열의 단백질을 준비하는 단계;
(b) 상기 단백질에 시험 물질을 접촉시키는 단계; 및
(c) 상기 시험 물질이 상기 단백질에 결합하는지 여부 또는 시험물질이 상기 단백질의 기능을 억제하는지 여부를 분석하는 단계; 상기 시험물질이 상기 단백질에 결합하거나 또는 단백질의 기능을 억제하면 간암의 예방 또는 치료용 물질로 판정된다.
- 삭제
- 삭제
- 제 8 항에 있어서, 상기 단백질은 세포 표면, 바이러스 표면 또는 분리된 형태(isolated form)로 존재하는 것을 특징으로 하는 방법.
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Toshimasa Okada et al, FEBS Letters (2003), vol. 555, pp. 583-590. |
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