KR101900664B1 - 자가면역 및 염증성 질환에서 림프내 투여를 위한 지방-유래 중간엽 줄기 세포 - Google Patents

자가면역 및 염증성 질환에서 림프내 투여를 위한 지방-유래 중간엽 줄기 세포 Download PDF

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KR101900664B1
KR101900664B1 KR1020137021276A KR20137021276A KR101900664B1 KR 101900664 B1 KR101900664 B1 KR 101900664B1 KR 1020137021276 A KR1020137021276 A KR 1020137021276A KR 20137021276 A KR20137021276 A KR 20137021276A KR 101900664 B1 KR101900664 B1 KR 101900664B1
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엘레우테리오 롬바르도
윌프레드 달레만스
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타이제닉스, 에스.에이.유.
타이제닉스 엔브이
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    • A61K35/35—Fat tissue; Adipocytes; Stromal cells; Connective tissues
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    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
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    • C12N5/0602—Vertebrate cells
    • C12N5/0652—Cells of skeletal and connective tissues; Mesenchyme
    • C12N5/0662—Stem cells
    • C12N5/0667—Adipose-derived stem cells [ADSC]; Adipose stromal stem cells
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K2035/122—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells for inducing tolerance or supression of immune responses

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  • Biochemistry (AREA)
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  • Orthopedic Medicine & Surgery (AREA)
  • Dermatology (AREA)
  • Pain & Pain Management (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
KR1020137021276A 2011-01-12 2012-01-12 자가면역 및 염증성 질환에서 림프내 투여를 위한 지방-유래 중간엽 줄기 세포 Active KR101900664B1 (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP11250025 2011-01-12
EP11250025.1 2011-01-12
PCT/IB2012/000097 WO2012095743A2 (en) 2011-01-12 2012-01-12 Methods and compositions for use in intralymphatic cellular therapies

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Publication Number Publication Date
KR20140127139A KR20140127139A (ko) 2014-11-03
KR101900664B1 true KR101900664B1 (ko) 2018-09-21

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US (1) US20140154274A1 (enExample)
EP (1) EP2663316A2 (enExample)
JP (2) JP6018081B2 (enExample)
KR (1) KR101900664B1 (enExample)
ES (1) ES2479544T1 (enExample)
WO (1) WO2012095743A2 (enExample)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060045872A1 (en) 2004-08-25 2006-03-02 Universidad Autonoma De Madrid Ciudad Universitaria de Cantoblanco Use of adipose tissue-derived stromal stem cells in treating fistula
DK1926813T4 (da) 2005-09-23 2019-08-19 Tigenix S A U Cellepopulationer med immunregulatorisk aktivitet, fremgangsmåde til isolering og anvendelser
US20160120910A1 (en) * 2013-06-25 2016-05-05 Tigenix S.A.U. Cell populations having immunoregulatory activity, methods for the preparation and uses thereof
US20150104470A1 (en) * 2013-10-11 2015-04-16 Neil H. Riordan Immune modulation by peri-lymphatic or intra-lymphatic cell therapy
US20170121685A1 (en) * 2015-11-02 2017-05-04 Tigenix S.A.U. Mesenchymal stem cell-derived exosomes and their uses
GB201604304D0 (en) 2016-03-14 2016-04-27 Tigenix S A U Adipose tissue-derived stromal stem cells for use in treating refractory complex perianal fistulas in crohn's disease
KR20190018420A (ko) * 2016-05-06 2019-02-22 각코우호징 오사카 이카야쿠카 다이가쿠 염증성 질환 치료용 줄기세포의 기능 강화를 위한 스타틴 봉입 나노입자 제제, 및 이를 함유하는 염증성 질환 치료용 기능 강화 줄기세포
JP6788003B2 (ja) * 2016-08-26 2020-11-18 学校法人大阪医科薬科大学 スタチン封入ナノ粒子を含有する機能増強幹細胞を含む炎症性疾患治療用細胞製剤
WO2021075525A1 (ja) 2019-10-17 2021-04-22 テルモ株式会社 炎症性疾患を処置するための細胞培養物
WO2021207192A1 (en) * 2020-04-08 2021-10-14 Figene, Llc Methods and compositions for allergy and asthma treatment using fibroblasts

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010015929A2 (en) * 2008-08-04 2010-02-11 Cellerix Sa Uses of mesenchymal stem cells

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Publication number Priority date Publication date Assignee Title
US9694038B2 (en) * 2000-04-06 2017-07-04 Wayne P. Franco Combination growth factor therapy and cell therapy for treatment of acute and chronic diseases of the organs
DE60334474D1 (de) * 2002-07-12 2010-11-18 Univ Johns Hopkins Reagenzien und verfahren zum eingriff in einzigartige klonotype lymphozyten-rezeptoren
EP2298863B1 (en) * 2004-03-22 2015-07-22 Mesoblast International Sàrl Mesenchymal stem cells and uses therefor
EP1729788B1 (en) * 2004-03-30 2009-11-25 Boston Scientific Limited Restenosis therapy using mesenchymal stem cells
US20060045872A1 (en) 2004-08-25 2006-03-02 Universidad Autonoma De Madrid Ciudad Universitaria de Cantoblanco Use of adipose tissue-derived stromal stem cells in treating fistula
DK1926813T4 (da) 2005-09-23 2019-08-19 Tigenix S A U Cellepopulationer med immunregulatorisk aktivitet, fremgangsmåde til isolering og anvendelser
CA2725637A1 (en) * 2008-05-27 2009-12-03 Pluristem Ltd. Methods of treating inflammatory colon diseases
JPWO2010101249A1 (ja) * 2009-03-06 2012-09-10 国立大学法人三重大学 Ｔ細胞の機能増強方法
CN107007626A (zh) * 2009-07-09 2017-08-04 蒂盖尼克斯公司 用于细胞治疗的方法和组合物
US20120201791A1 (en) * 2009-10-15 2012-08-09 Tai June Yoo Methods of treating diseases or conditions using mesenchymal stem cells

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010015929A2 (en) * 2008-08-04 2010-02-11 Cellerix Sa Uses of mesenchymal stem cells

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Arthritis & Rheumatism, Vol. 60, No. 4, pp. 1006-1019 (2009.04)*

Also Published As

Publication number Publication date
JP6018081B2 (ja) 2016-11-02
WO2012095743A2 (en) 2012-07-19
ES2479544T1 (es) 2014-08-20
JP2017035094A (ja) 2017-02-16
EP2663316A2 (en) 2013-11-20
JP2014502628A (ja) 2014-02-03
KR20140127139A (ko) 2014-11-03
WO2012095743A3 (en) 2012-11-01
US20140154274A1 (en) 2014-06-05

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